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Aliases for ARHGAP9 Gene

Aliases for ARHGAP9 Gene

  • Rho GTPase Activating Protein 9 2 3
  • Rho-Type GTPase-Activating Protein 9 3 4
  • Rho GTPase-Activating Protein 9 3
  • RGL1 3
  • 10C 3

External Ids for ARHGAP9 Gene

Previous GeneCards Identifiers for ARHGAP9 Gene

  • GC12M059326
  • GC12M058009
  • GC12M057582
  • GC12M056152
  • GC12M057866
  • GC12M054903

Summaries for ARHGAP9 Gene

Entrez Gene Summary for ARHGAP9 Gene

  • This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP9 Gene

ARHGAP9 (Rho GTPase Activating Protein 9) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for ARHGAP9 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Gene Wiki entry for ARHGAP9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP9 Gene

Genomics for ARHGAP9 Gene

Regulatory Elements for ARHGAP9 Gene

Transcription factor binding sites by QIAGEN in the ARHGAP9 gene promoter:

Genomic Location for ARHGAP9 Gene

Start:
57,472,255 bp from pter
End:
57,488,814 bp from pter
Size:
16,560 bases
Orientation:
Minus strand

Genomic View for ARHGAP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP9 Gene

Proteins for ARHGAP9 Gene

  • Protein details for ARHGAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR9-RHG09_HUMAN
    Recommended name:
    Rho GTPase-activating protein 9
    Protein Accession:
    Q9BRR9
    Secondary Accessions:
    • B4DVI3
    • E9PDX9
    • Q8NAF3
    • Q8TCJ3
    • Q8WYR0
    • Q96EZ2
    • Q96S74

    Protein attributes for ARHGAP9 Gene

    Size:
    750 amino acids
    Molecular mass:
    83260 Da
    Quaternary structure:
    • Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for ARHGAP9 Gene

    Alternative splice isoforms for ARHGAP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP9 Gene

Proteomics data for ARHGAP9 Gene at MOPED

Post-translational modifications for ARHGAP9 Gene

  • Ubiquitination at Lys333, Lys522, and Lys588
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP9 Gene

Domains for ARHGAP9 Gene

Gene Families for ARHGAP9 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for ARHGAP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRR9

UniProtKB/Swiss-Prot:

RHG09_HUMAN :
  • Q9BRR9
Domain:
  • A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with ARHGAP9: view

Function for ARHGAP9 Gene

Molecular function for ARHGAP9 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Gene Ontology (GO) - Molecular Function for ARHGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 11396949
GO:0005515 protein binding IPI 25416956
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 17339315
genes like me logo Genes that share ontologies with ARHGAP9: view

Phenotypes for ARHGAP9 Gene

GenomeRNAi human phenotypes for ARHGAP9:
genes like me logo Genes that share phenotypes with ARHGAP9: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP9 Gene

Localization for ARHGAP9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP9 Gene COMPARTMENTS Subcellular localization image for ARHGAP9 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP9 Gene

Pathways for ARHGAP9 Gene

genes like me logo Genes that share pathways with ARHGAP9: view

Gene Ontology (GO) - Biological Process for ARHGAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP9: view

Transcripts for ARHGAP9 Gene

Unigene Clusters for ARHGAP9 Gene

Rho GTPase activating protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - - -
SP9:
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: -
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -

ExUns: 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ARHGAP9 Gene

GeneLoc Exon Structure for
ARHGAP9
ECgene alternative splicing isoforms for
ARHGAP9

Expression for ARHGAP9 Gene

mRNA expression in normal human tissues for ARHGAP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP9 Gene

This gene is overexpressed in Whole Blood (32.3) and Spleen (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP9 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP9 Gene Hs.437126

mRNA Expression by UniProt/SwissProt for ARHGAP9 Gene

Q9BRR9-RHG09_HUMAN
Tissue specificity: Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.
genes like me logo Genes that share expressions with ARHGAP9: view

Orthologs for ARHGAP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP9 35
  • 99.45 (n)
  • 98.77 (a)
ARHGAP9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP9 35
  • 86.59 (n)
  • 85.23 (a)
ARHGAP9 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
ARHGAP9 35
  • 86.37 (n)
  • 85.09 (a)
mouse
(Mus musculus)
Mammalia Arhgap9 35
  • 80.53 (n)
  • 78.89 (a)
Arhgap9 16
Arhgap9 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP9 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap9 35
  • 77.91 (n)
  • 74.87 (a)
lizard
(Anolis carolinensis)
Reptilia ARHGAP9 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap9 35
  • 52.4 (n)
  • 47.66 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01088365.1 36
  • 42 (a)
OneToOne
LOC100334461 35
  • 57.39 (n)
  • 54.64 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-325 36
  • 19 (a)
OneToMany
C38D4.5 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for ARHGAP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP9 Gene

ENSEMBL:
Gene Tree for ARHGAP9 (if available)
TreeFam:
Gene Tree for ARHGAP9 (if available)

Paralogs for ARHGAP9 Gene

genes like me logo Genes that share paralogs with ARHGAP9: view

Variants for ARHGAP9 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs472895 -- 57,481,445(-) tgaaa(C/G)cctgt upstream-variant-2KB, intron-variant
rs486699 -- 57,476,338(-) CAGGA(G/T)GGGTG intron-variant
rs509941 -- 57,476,594(+) CCTGA(C/G)CTTGC reference, missense
rs509962 -- 57,476,595(+) CTGAG(C/G)TTGCG missense, reference
rs511752 -- 57,483,373(+) TGATA(C/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP9 Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv469411 CNV Loss 19166990
nsv899119 CNV Loss 21882294
nsv819597 CNV Gain 19587683
nsv819781 CNV Loss 19587683

Relevant External Links for ARHGAP9 Gene

HapMap Linkage Disequilibrium report
ARHGAP9
Human Gene Mutation Database (HGMD)
ARHGAP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP9 Gene

Disorders for ARHGAP9 Gene

Relevant External Links for ARHGAP9

Genetic Association Database (GAD)
ARHGAP9
Human Genome Epidemiology (HuGE) Navigator
ARHGAP9
genes like me logo Genes that share disorders with ARHGAP9: view

No data available for UniProtKB/Swiss-Prot for ARHGAP9 Gene

Publications for ARHGAP9 Gene

  1. Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. (PMID: 11396949) Furukawa Y. … Nakamura Y. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. (PMID: 17339315) Ceccarelli D.F. … Sicheri F. (J. Biol. Chem. 2007) 3 4
  5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4

Products for ARHGAP9 Gene

  • antibodies-online proteins for ARHGAP9
  • antibodies-online antibodies for ARHGAP9
  • antibodies-online kits for ARHGAP9

Sources for ARHGAP9 Gene

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