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ARHGAP9 Gene

protein-coding   GIFtS: 63
GCID: GC12M057866

Rho GTPase Activating Protein 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 91 2
Rho-Type GTPase-Activating Protein 92 3
10C2
RGL12
Rho GTPase-Activating Protein 92

External Ids:    HGNC: 141301   Entrez Gene: 643332   Ensembl: ENSG000001233297   OMIM: 6105765   UniProtKB: Q9BRR93   

Export aliases for ARHGAP9 gene to outside databases

Previous GC identifers: GC12M059326 GC12M058009 GC12M057582 GC12M056152 GC12M054903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP9 Gene:
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP
activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is
implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGAP9 Gene:
ARHGAP9 (Rho GTPase activating protein 9) is a protein-coding gene. Diseases associated with ARHGAP9 include spasticity. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG09_HUMAN, Q9BRR9
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a
substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of
hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for
phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and
phosphatidylinositol 4,5-bisphosphate

Gene Wiki entry for ARHGAP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP9 gene promoter:
         NF-1   HSF2   CUTL1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGAP9 promoter sequence
   Search Chromatin IP Primers for ARHGAP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

ARHGAP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057866:  view genomic region     (about GC identifiers)

Start:
57,866,038 bp from pter      End:
57,882,597 bp from pter
Size:
16,560 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHG09_HUMAN, Q9BRR9 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 9  
Size: 750 amino acids; 83260 Da
Subunit: Interacts with FASLG
3 PDB 3D structures from and Proteopedia for ARHGAP9:
2P0D (3D)        2P0F (3D)        2P0H (3D)    
Secondary accessions: B4DVI3 E9PDX9 Q8NAF3 Q8TCJ3 Q8WYR0 Q96EZ2 Q96S74
Alternative splicing: 5 isoforms:  Q9BRR9-1   Q9BRR9-2   Q9BRR9-3   Q9BRR9-4   Q9BRR9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP9: NX_Q9BRR9

Explore proteomics data for ARHGAP9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys333, Lys522, Lys588
  • Modification sites at PhosphoSitePlus

  • See ARHGAP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001073625.1  NP_001073626.1  NP_115885.2  

    ENSEMBL proteins: 
     ENSP00000377380   ENSP00000394307   ENSP00000377386   ENSP00000448404   ENSP00000473445  
     ENSP00000397950   ENSP00000448423   ENSP00000449829   ENSP00000450256   ENSP00000446932  
     ENSP00000448424   ENSP00000450223   ENSP00000448358   ENSP00000348782  
    Reactome Protein details: Q9BRR9

    ARHGAP9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    Selected InterPro protein domains (see all 7):
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR015767 Rho_GTPase_activating

    Graphical View of Domain Structure for InterPro Entry Q9BRR9

    ProtoNet protein and cluster: Q9BRR9

    3 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG09_HUMAN, Q9BRR9
    Domain: A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction
    with phosphoinositides
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 WW domain


    ARHGAP9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG09_HUMAN, Q9BRR9
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a
    substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of
    hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for
    phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and
    phosphatidylinositol 4,5-bisphosphate

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IDA11396949
    GO:0005515protein binding ----
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA17339315
         
    ARHGAP9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGAP9:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGAP9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP9 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Regulation of RhoA activity
    Regulation of RhoA activity
    4Regulation of RAC1 activity
    Regulation of RAC1 activity
    5G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARHGAP9
        G-protein signaling Regulation of RAC1 activity

    2 BioSystems Pathways for ARHGAP9
        Regulation of RhoA activity
    Regulation of RAC1 activity

    1 Reactome Pathway for ARHGAP9
        Rho GTPase cycle



    ARHGAP9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP9
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP9 (Q9BRR92, 3 ENSP000003773804) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930622, 3, ENSP000003401764MINT-67740 I2D: score=5 STRING: ENSP00000340176
    SMAD9O151982, 3MINT-62091 I2D: score=3 
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0043547positive regulation of GTPase activity IDA11396949
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP9 (RHG09)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGAP9 gene (3 alternative transcripts): 
    NM_001080156.1  NM_001080157.1  NM_032496.2  

    Unigene Cluster for ARHGAP9:

    Rho GTPase activating protein 9
    Hs.437126  [show with all ESTs]
    Unigene Representative Sequence: BC006107
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000393791(uc001sny.3 uc001soc.3) ENST00000552953 ENST00000424809(uc001sob.3)
    ENST00000393797(uc001sod.3 uc001soe.1) ENST00000550399 ENST00000546200(uc001soa.3)
    ENST00000550288 ENST00000430041(uc001snz.3) ENST00000550440 ENST00000550130
    ENST00000546704 ENST00000548139 ENST00000548148 ENST00000550454 ENST00000547200
    ENST00000552604 ENST00000552420(uc010sro.1) ENST00000551574
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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP9 3' UTR sequence
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      Search QuantiFast Probe-based Assays in human, mouse, rat ARHGAP9

    Additional mRNA sequence: 

    AB030239.1 AB051853.1 AK092763.1 AK131415.1 AK300910.1 AK301095.1 AK304107.1 BC006107.1 
    BC011820.1 

    18 DOTS entries:

    DT.121187579  DT.100778195  DT.100756375  DT.121187383  DT.121187411  DT.206685  DT.40106320  DT.95168316 
    DT.100022468  DT.121187562  DT.40109252  DT.102841105  DT.95197306  DT.95089157  DT.100778193  DT.91671832 
    DT.100768213  DT.95168317 

    Selected AceView cDNA sequences (see all 97):

    CR618863 BQ574628 AK092763 BQ072642 CB528354 AL548053 BC006107 NM_032496 
    AL713803 BC011820 AB051853 BI830251 BX119308 CA446019 AI708450 AX747713 
    CR610490 AA446809 BQ072943 BX361130 R82922 AW075857 AA356695 AW028287 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP9 (see all 21)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
    SP1:        -                       -     -     -     -     -     -     -     -     -                             -                 -     -                     
    SP2:                                -     -     -     -     -     -     -     -     -                             -                 -     -                     
    SP3:                                                                                                              -                 -     -                     
    SP4:                                                                                                                                                            
    SP5:                                                        -     -     -     -     -                             -                 -     -                     

    ExUns: 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21
    SP1:                                      -                             -                     
    SP2:                                      -                             -           -         
    SP3:                                      -                             -                     
    SP4:                                      -                             -                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ARHGAP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTTTAA
    ARHGAP9 Expression
    About this image


    ARHGAP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
             Extraocular Muscles
     
     Thymus (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    ARHGAP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437126

    UniProtKB/Swiss-Prot: RHG09_HUMAN, Q9BRR9
    Tissue specificity: Predominantly expressed in peripheral blood leukocytes, spleen, and thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap91 , 5 Rho GTPase activating protein 91, 5 80.53(n)1
    78.89(a)1
      10 (74.50 cM)5
    2164451  NM_001285785.11  NP_001272714.11 
     1273237275 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP96
    Rho GTPase activating protein 9
    45(a)
    1 ↔ 1
    GL343212.1(628646-661797)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap91 Rho GTPase activating protein 9 52.4(n)
    47.66(a)
      100494875  XM_002939430.2  XP_002939476.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003344611 rho GTPase-activating protein 15-like 57.39(n)
    54.64(a)
      100334461  XM_005172128.1  XP_005172185.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C38D4.53 chimaerin 30(a)   III(4868704-4874366)   --


    ENSEMBL Gene Tree for ARHGAP9 (if available)
    TreeFam Gene Tree for ARHGAP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP9 gene
    ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP232  CHN12  ARHGAP262  ARHGAP152  
    ARHGAP122  OPHN12  ARHGAP422  
    Selected SIMAP similar genes for ARHGAP9 using alignment to 11 protein entries:     RHG09_HUMAN (see all proteins) (see all similar genes):
    ARHGAP15    ARHGAP12    ARHGAP30    ARHGAP32    DKFZp451F1115    RICS
    ARHGAP5    ARAP3    ARHGAP18    ARHGAP27    CHN1    ARHGAP1
    ARHGAP40    ARHGAP8    BPGAP1    FKSG42    MYO9A    FAM13A

    ARHGAP9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP9 (see all 305)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115442381,2,,4
    C,F,Hother157704453(-) CCTCCT/GCAGGC 6 /A /S mis120Minor allele frequency- G:0.46NS EA NA EU 7455
    rs1383493501,2
    C--54904467(+) GTAAC-/AAAAAA 3 -- int10--------
    rs1397836541,2
    --54904564(+) TCAGGA/GGCTGC 3 -- int10--------
    rs359459701,2
    C,F--54904802(+) TTTGAC/TGGGCA 3 -- int13Minor allele frequency- T:0.21WA NA 124
    rs349372981,2
    --54904994(+) GAACCC/TGGGAG 3 -- int10--------
    rs1838904391,2
    C--54905027(+) ATTGCA/GCCACT 3 -- int10--------
    rs1877122621,2
    C--54905071(+) TCTCAA/CAAATA 3 -- int10--------
    rs1400170001,2
    C--54905076(+) AAAAT-/AAATA 
            
    AAATA
    3 -- int10--------
    rs1476230821,2
    C--54905320(+) AGCCTA/GTTAAT 5 T I mis1 int10--------
    rs2020316201,2
    --54905334(+) TGTATC/GTGAGA 5 H Q mis1 int10--------

    HapMap Linkage Disequilibrium report for ARHGAP9 (57866038 - 57882597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ARHGAP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469411CNV Loss19166990
    nsv899119CNV Loss21882294
    nsv819781CNV Loss19587683
    nsv899117CNV Loss21882294
    nsv819597CNV Gain19587683
    nsv899118CNV Gain21882294
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ARHGAP9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP9
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610576    OMIM disorders: --

    1 disease for ARHGAP9:    
    About MalaCards
    spasticity


    ARHGAP9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP9
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP9 (2 documents)

    Export disorders for ARHGAP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP9 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ARHGAP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. (PubMed id 11396949)1, 2, 3, 9 Furukawa Y.... Nakamura Y. (Biochem. Biophys. Res. Commun. 2001)
    2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    4. Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. (PubMed id 17339315)1, 2 Ceccarelli D.F....Sicheri F. (J. Biol. Chem. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64333 HGNC: 14130 AceView: ARHGAP9 Ensembl:ENSG00000123329 euGenes: HUgn64333
    ECgene: ARHGAP9 H-InvDB: ARHGAP9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP9 gene:
    Search GeneIP for patents involving ARHGAP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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