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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP8 Gene

protein-coding   GIFtS: 49
GCID: GC22P045099

Rho GTPase Activating Protein 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 81 2     BCH Domain-Containing Cdc42GAP-Like Protein2
Rho-Type GTPase-Activating Protein 82 3     BNIP-2 And Cdc42GAP Homology Domain-Containing, Proline-Rich And
Cdc42GAP-Like Protein Subtype-12
BPGAP12 5     Rho GTPase-Activating Protein 82
PP6102     

External Ids:    HGNC: 6771   Entrez Gene: 237792   Ensembl: ENSG000002414847   OMIM: 6094055   UniProtKB: P852983   

Export aliases for ARHGAP8 gene to outside databases

Previous GC identifers: GC22P041733 GC22P043341 GC22P043349 GC22P043393 GC22P043527 GC22P043451 GC22P045148 GC22P028096


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP8 Gene:
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling
pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active
(GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a
multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in
multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into
this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. (provided by
RefSeq, Nov 2010)

GeneCards Summary for ARHGAP8 Gene: 
ARHGAP8 (Rho GTPase activating protein 8) is a protein-coding gene. Diseases associated with ARHGAP8 include cleft palate, and cleft lip, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include protein binding and Rho GTPase activator activity. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG08_HUMAN, P85298
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)

Gene Wiki entry for ARHGAP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP8 gene promoter:
         GR   RP58   GR-beta   HNF-3beta   Roaz   AREB6   HEN1   ZID   GR-alpha   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13.3

ARHGAP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP8 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P045099:  view genomic region     (about GC identifiers)

Start:
45,098,355 bp from pter      End:
45,258,665 bp from pter
Size:
160,311 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG08_HUMAN, P85298 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 8  
Size: 464 amino acids; 53484 Da
Secondary accessions: A6ZJ80 O75983 O95695 Q96RW1 Q96RW2 Q9HA49 Q9HC46 Q9NSG0 Q9NVX8 Q9NXL1
Q9UH20
Alternative splicing: 4 isoforms:  P85298-1, Q9NSG0-6   P85298-2, Q9NSG0-7   P85298-3   P85298-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP8: NX_P85298

Explore proteomics data for ARHGAP8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P85298

  • ARHGAP8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP8 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001017526.1  NP_001185655.1  NP_851852.2  

    ENSEMBL proteins: 
     ENSP00000374424   ENSP00000379425   ENSP00000403618   ENSP00000337287   ENSP00000348407  
     ENSP00000402775   ENSP00000374422   ENSP00000429240   ENSP00000374423  
    Reactome Protein details: P85298
    Human Recombinant Protein Products for ARHGAP8: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGAP8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001251 CRAL-TRIO_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry P85298

    ProtoNet protein and cluster: P85298

    UniProtKB/Swiss-Prot: RHG08_HUMAN, P85298
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG08_HUMAN, P85298
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Genatlas biochemistry entry for ARHGAP8:
    Rho GTPase activating protein 8

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity IDA--
    GO:0005515protein binding IPI--
         
    ARHGAP8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGAP8:
     Altered focal adhesion (FA) or 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3Regulation of RhoA activity
    Regulation of RhoA activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARHGAP8
        Regulation of RhoA activity

    3        Reactome Pathways for ARHGAP8
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for ARHGAP8 (P852983 ENSP000003744244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTTNQ142473, ENSP000003018434I2D: score=1 STRING: ENSP00000301843
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    SH3GL1Q999613, ENSP000002698864I2D: score=1 STRING: ENSP00000269886
    BNIP2Q129823, ENSP000002678594I2D: score=1 STRING: ENSP00000267859
    PRKAA2P546463I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032321positive regulation of Rho GTPase activity IDA--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--
    GO:0070374positive regulation of ERK1 and ERK2 cascade IDA--

    ARHGAP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP8 (RHG08)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP8 / RHG08

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP8 gene (3 alternative transcripts): 
    NM_001017526.1  NM_001198726.1  NM_181335.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389774(uc010gzv.3 uc003bfj.3 uc003bfk.3) ENST00000460809(uc003bfi.3)
    ENST00000396119 ENST00000447333 ENST00000336963 ENST00000356099 ENST00000412433
    ENST00000469872 ENST00000389772(uc003bfl.3) ENST00000495219 ENST00000498310
    ENST00000469342 ENST00000517296(uc003bfd.3) ENST00000389773(uc011aqi.2 uc011aqj.2)

    miRNA
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    24/276 AceView cDNA sequences (see all 276):

    BC067824 BX096591 BG170601 CR611486 NM_017701 CR598211 AW673087 BX345142 
    CR600027 NM_181333 BG741612 CR605746 AL355192 BF196508 BM976456 BE887282 
    CA313656 R69153 H55372 CR613509 AI589661 AK091884 CR599270 AF195968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP8 expression in normal human tissues (normalized intensities)      ARHGAP8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP8 Expression
    About this image


    ARHGAP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ductal cells   
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast

    See ARHGAP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP8

    UniProtKB/Swiss-Prot: RHG08_HUMAN, P85298
    Tissue specificity: Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small
    intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of
    colorectal tumors examined

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP8 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap81 , 5 Rho GTPase activating protein 81, 5 84.02(n)1
    86.67(a)1
      15 (39.99 cM)5
    731671  NM_001164627.11  NP_001158099.11 
     847200835 
    chicken
    (Gallus gallus)
    Aves ARHGAP81 Rho GTPase activating protein 8 69.17(n)
    75.65(a)
      418239  NM_001204389.1  NP_001191318.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    5(84941827-84966554)
    African clawed frog
    (Xenopus laevis)
    Amphibia arhgap8-prov2 Rho GTPase activating protein 8 76.55(n)    BC042252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP68F3 Rho GTPase activator 34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.83 GTPase-activating (rhoGAP) like protein 36(a)   II(11464575-11466218)   --


    ENSEMBL Gene Tree for ARHGAP8 (if available)
    TreeFam Gene Tree for ARHGAP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP8 gene
    PRR5-ARHGAP81 2  ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  
    ARHGAP442  ARHGAP12  SH3BP12  ARHGAP252  SRGAP22  ARHGAP42  
    12 SIMAP similar genes for ARHGAP8 using alignment to 12 protein entries:     RHG08_HUMAN (see all proteins):
    BPGAP1    LOC553158    PRR5-ARHGAP8    PRR5    ARHGAP1    ARHGAP12
    FAM13A    BNIP2    ARHGAP9    PRUNE2    ATCAY    BNIPL

    ARHGAP8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/16 SNPs in ARHGAP8 are shown (see all 16)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0611824
    ----see VAR_0611822 P R mis40--------
    VAR_0491384
    ----see VAR_0491382 Y C mis40--------
    VAR_0491404
    ----see VAR_0491402 P L mis40--------
    VAR_0491394
    ----see VAR_0491392 G R mis40--------
    rs1484518951,2
    C--45155510(+) TGCGC-/AGCAGAG 3 -- int10--------
    rs3714321081,2
    C--45168232(+) TTTTT-/TTTTTTT 3 -- int10--------
    rs347449841,2
    C--45170398(+) GGAGA-/TTTTTT 2 -- int10--------
    rs58456691,2
    C--45172332(+) AAAAAA/-GAAAA 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1474290141,2
    C--45173879(+) ACTAT-/TTTA  
            
    TTTAT
    3 -- int10--------
    rs598028961,2
    C--45173882(+) TATTT-/ATTT  
            
    CCATA
    3 -- int11Minor allele frequency- ATTT:0.00NA 2

    HapMap Linkage Disequilibrium report for ARHGAP8 (45098355 - 45258665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for ARHGAP8 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724370CNV Deletion23290073
    esv2663583CNV Deletion23128226
    esv2724371CNV Deletion23290073
    esv2667102CNV Deletion23128226
    esv2673983CNV Deletion23128226
    esv2724372CNV Deletion23290073
    esv1192293CNV Deletion17803354
    esv2674450CNV Deletion23128226
    esv2512679CNV Deletion19546169
    esv2259848CNV Deletion18987734

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609405    OMIM disorders: --

    5 diseases for ARHGAP8:    About MalaCards
    cleft palate    cleft lip    cervical cancer    cervicitis
    breast cancer


    ARHGAP8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP8
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP8 (4 documents)

    Export disorders for ARHGAP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP8 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ARHGAP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers. (PubMed id 15225876)1, 2 Johnstone C.N.... Rustgi A.K. (2004)
    5. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. (PubMed id 15944398)1, 9 Lua B.L. and Low B.C. (2005)
    6. Active Mek2 as a regulatory scaffold that promotes Pi n1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell m igration. (PubMed id 20179103)1, 9 Pan C.Q....Low B.C. (2010)
    7. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. (PubMed id 12944407)1, 9 Shang X.... Low B.C. (2003)
    8. Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8. (PubMed id 12559566)1, 9 Shan Z....Popescu N.C. (2003)
    9. Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ6. (PubMed id 22554406)1 Kang S.J....Porjesz B. (2012)
    10. Genome-wide meta-analyses of nonsyndromic cleft lip wi th or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....Nothen M.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23779 HGNC: 677 AceView: ARHGAP8 Ensembl:ENSG00000241484 euGenes: HUgn23779
    ECgene: ARHGAP8 H-InvDB: ARHGAP8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP8 gene:
    Search GeneIP for patents involving ARHGAP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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