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Aliases for ARHGAP8 Gene

Aliases for ARHGAP8 Gene

  • Rho GTPase Activating Protein 8 2 3 5
  • Rho-Type GTPase-Activating Protein 8 3 4
  • BNIP-2 And Cdc42GAP Homology Domain-Containing, Proline-Rich And Cdc42GAP-Like Protein Subtype-1 3
  • BCH Domain-Containing Cdc42GAP-Like Protein 3
  • Rho GTPase-Activating Protein 8 3
  • BPGAP1 3
  • PP610 3

External Ids for ARHGAP8 Gene

Previous GeneCards Identifiers for ARHGAP8 Gene

  • GC22P041733
  • GC22P043341
  • GC22P043349
  • GC22P043393
  • GC22P043527
  • GC22P043451
  • GC22P045148
  • GC22P028096
  • GC22P045099

Summaries for ARHGAP8 Gene

Entrez Gene Summary for ARHGAP8 Gene

  • This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARHGAP8 Gene

ARHGAP8 (Rho GTPase Activating Protein 8) is a Protein Coding gene. Diseases associated with ARHGAP8 include Cervix Carcinoma. Among its related pathways are Regulation of RhoA activity and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is PRR5-ARHGAP8.

UniProtKB/Swiss-Prot for ARHGAP8 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP8 Gene

Genomics for ARHGAP8 Gene

Regulatory Elements for ARHGAP8 Gene

Enhancers for ARHGAP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F044752 1.1 Ensembl ENCODE 18.6 +2.0 1959 4.5 KLF1 TEAD4 ZIC2 ZFHX2 GLIS2 ZBTB48 POLR2A PATZ1 PRDM10 FOS ARHGAP8 KIAA0930 LOC105373062
GH22F044680 1.6 FANTOM5 Ensembl ENCODE 12.6 -68.3 -68322 6.9 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF143 ZNF263 SP3 ZHX2 JUNB ENSG00000273243 ARHGAP8 KIAA1644 PRR5 PRR5-ARHGAP8
GH22F044676 1.3 Ensembl ENCODE 12.6 -75.3 -75349 2.4 ARNT ARID4B DMAP1 FOS ZNF263 SP3 MXD4 KAT8 SMARCA4 GLIS1 PRR5-ARHGAP8 ARHGAP8 ENSG00000232363 PRR5
GH22F044727 0.9 Ensembl ENCODE 6.4 -23.3 -23315 3.2 CTCF USF1 BHLHE40 ZIC2 RAD21 ZKSCAN1 GLIS1 SMC3 HNF4A FOS ARHGAP8 NUP50 PIR46615 GC22P044710
GH22F044735 1 Ensembl ENCODE 5.4 -16.5 -16456 1.0 CTCF KLF17 ARID4B RAD21 HIC1 GLIS2 SCRT2 ZNF143 SMC3 SCRT1 ARHGAP8 PIR46615 GC22P044753
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001533175 243 1600 KLF1 ZFHX2 GLIS2 POLR2A PATZ1 PRDM10 KLF8 ZBTB20 EZH2 EGR2

Genomic Location for ARHGAP8 Gene

44,752,558 bp from pter
44,862,788 bp from pter
110,231 bases
Plus strand

Genomic View for ARHGAP8 Gene

Genes around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP8 Gene

Proteins for ARHGAP8 Gene

  • Protein details for ARHGAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 8
    Protein Accession:
    Secondary Accessions:
    • A6ZJ79
    • A6ZJ80
    • O75983
    • O95695
    • Q96RW1
    • Q96RW2
    • Q9HA49
    • Q9HC46
    • Q9NSG0
    • Q9NVX8
    • Q9NXL1
    • Q9UH20

    Protein attributes for ARHGAP8 Gene

    464 amino acids
    Molecular mass:
    53484 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP8 Gene

neXtProt entry for ARHGAP8 Gene

Post-translational modifications for ARHGAP8 Gene

  • Ubiquitination at Lys 95
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP8 Gene

Domains & Families for ARHGAP8 Gene

Protein Domains for ARHGAP8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP8: view

Function for ARHGAP8 Gene

Molecular function for ARHGAP8 Gene

GENATLAS Biochemistry:
Rho GTPase activating protein 8
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 20179103
genes like me logo Genes that share ontologies with ARHGAP8: view
genes like me logo Genes that share phenotypes with ARHGAP8: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP8 Gene

Localization for ARHGAP8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP8 gene
Compartment Confidence
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP8 Gene

Pathways & Interactions for ARHGAP8 Gene

genes like me logo Genes that share pathways with ARHGAP8: view

Pathways by source for ARHGAP8 Gene

1 BioSystems pathway for ARHGAP8 Gene
3 Reactome pathways for ARHGAP8 Gene

Interacting Proteins for ARHGAP8 Gene

Gene Ontology (GO) - Biological Process for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 20179103
genes like me logo Genes that share ontologies with ARHGAP8: view

No data available for SIGNOR curated interactions for ARHGAP8 Gene

Transcripts for ARHGAP8 Gene

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP8 Gene

No ASD Table

Relevant External Links for ARHGAP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP8 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP8 Gene

This gene is overexpressed in Spleen (x9.4), Kidney - Cortex (x7.3), and Thyroid (x4.5).

Protein differential expression in normal tissues from HIPED for ARHGAP8 Gene

This gene is overexpressed in Ovary (22.4), Prostate (19.0), and Testis (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP8 Gene

Protein tissue co-expression partners for ARHGAP8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP8 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP8 Gene:

Tissue specificity: Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined.
genes like me logo Genes that share expression patterns with ARHGAP8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGAP8 Gene

Orthologs for ARHGAP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP8 34
  • 92.99 (n)
(Canis familiaris)
Mammalia ARHGAP8 34 35
  • 85.28 (n)
(Rattus norvegicus)
Mammalia Arhgap8 34
  • 84.19 (n)
(Mus musculus)
Mammalia Arhgap8 34 35
  • 84.1 (n)
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
(Gallus gallus)
Aves ARHGAP8 34 35
  • 69.26 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap8 34
  • 68.39 (n)
Str.17718 34
African clawed frog
(Xenopus laevis)
Amphibia arhgap8-prov 34
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 36 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea W02B12.8 36
  • 36 (a)
rga-1 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
Species where no ortholog for ARHGAP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ARHGAP8 Gene

Gene Tree for ARHGAP8 (if available)
Gene Tree for ARHGAP8 (if available)

Paralogs for ARHGAP8 Gene

Variants for ARHGAP8 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001726 -- 44,796,931(-) TTAGA(C/T)CACCC intron-variant
rs1001727 -- 44,796,913(-) GTTGA(C/G)GGCAC intron-variant
rs1001728 -- 44,796,780(-) acaat(C/T)acagc intron-variant
rs10222207 -- 44,806,359(+) GCATG(A/G)TGTGA intron-variant
rs10222215 -- 44,806,739(+) CACGA(A/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP8 Gene

Variant ID Type Subtype PubMed ID
nsv829268 CNV gain 20364138
nsv589122 CNV loss 21841781
nsv589121 CNV gain 21841781
nsv589108 CNV loss 21841781
nsv471208 CNV gain 18288195
nsv459902 CNV loss 19166990
nsv459901 CNV gain 19166990
nsv1123602 CNV deletion 24896259
nsv1059020 CNV loss 25217958
nsv1056293 CNV loss 25217958
esv3647910 CNV loss 21293372
esv3647909 CNV loss 21293372
esv3647907 CNV loss 21293372
esv3647906 CNV loss 21293372
esv3568441 CNV loss 25503493
esv3558231 CNV deletion 23714750
esv2758842 CNV loss 17122850
esv2724374 CNV deletion 23290073
esv2724372 CNV deletion 23290073
esv2724371 CNV deletion 23290073
esv2724370 CNV deletion 23290073
esv2674450 CNV deletion 23128226
esv2673983 CNV deletion 23128226
esv2667102 CNV deletion 23128226
esv2663583 CNV deletion 23128226
esv2658024 CNV deletion 23128226
esv2512679 CNV deletion 19546169
esv2259848 CNV deletion 18987734
esv1192293 CNV deletion 17803354
dgv4586n100 CNV loss 25217958
dgv2467n106 CNV deletion 24896259
dgv2466n106 CNV deletion 24896259
dgv1326e212 CNV loss 25503493

Variation tolerance for ARHGAP8 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP8 Gene

Disorders for ARHGAP8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cancer of cervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGAP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP8 Gene

Publications for ARHGAP8 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 64
  2. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. (PMID: 20179103) Pan C.Q. … Low B.C. (J. Cell. Sci. 2010) 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. (PMID: 15944398) Lua B.L. … Low B.C. (J. Cell. Sci. 2005) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ARHGAP8 Gene

Sources for ARHGAP8 Gene

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