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Aliases for ARHGAP8 Gene

Aliases for ARHGAP8 Gene

  • Rho GTPase Activating Protein 8 2 3 5
  • Rho-Type GTPase-Activating Protein 8 3 4
  • BNIP-2 And Cdc42GAP Homology Domain-Containing, Proline-Rich And Cdc42GAP-Like Protein Subtype-1 3
  • BCH Domain-Containing Cdc42GAP-Like Protein 3
  • BPGAP1 3
  • PP610 3

External Ids for ARHGAP8 Gene

Previous GeneCards Identifiers for ARHGAP8 Gene

  • GC22P041733
  • GC22P043341
  • GC22P043349
  • GC22P043393
  • GC22P043527
  • GC22P043451
  • GC22P045148
  • GC22P028096
  • GC22P045099

Summaries for ARHGAP8 Gene

Entrez Gene Summary for ARHGAP8 Gene

  • This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARHGAP8 Gene

ARHGAP8 (Rho GTPase Activating Protein 8) is a Protein Coding gene. Diseases associated with ARHGAP8 include Cervix Carcinoma. Among its related pathways are Signaling by Rho GTPases and Regulation of RhoA activity. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP8 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP8 Gene

Genomics for ARHGAP8 Gene

Regulatory Elements for ARHGAP8 Gene

Enhancers for ARHGAP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP8 Gene

44,752,558 bp from pter
44,862,788 bp from pter
110,231 bases
Plus strand

Genomic View for ARHGAP8 Gene

Genes around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP8 Gene

Proteins for ARHGAP8 Gene

  • Protein details for ARHGAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 8
    Protein Accession:
    Secondary Accessions:
    • A6ZJ79
    • A6ZJ80
    • O75983
    • O95695
    • Q96RW1
    • Q96RW2
    • Q9HA49
    • Q9HC46
    • Q9NSG0
    • Q9NVX8
    • Q9NXL1
    • Q9UH20

    Protein attributes for ARHGAP8 Gene

    464 amino acids
    Molecular mass:
    53484 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP8 Gene

neXtProt entry for ARHGAP8 Gene

Proteomics data for ARHGAP8 Gene at MOPED

Post-translational modifications for ARHGAP8 Gene

  • Ubiquitination at Lys 95
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP8 Gene

Domains & Families for ARHGAP8 Gene

Gene Families for ARHGAP8 Gene

Protein Domains for ARHGAP8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP8: view

Function for ARHGAP8 Gene

Molecular function for ARHGAP8 Gene

GENATLAS Biochemistry:
Rho GTPase activating protein 8
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP8: view
genes like me logo Genes that share phenotypes with ARHGAP8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP8 Gene

Localization for ARHGAP8 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP8 Gene COMPARTMENTS Subcellular localization image for ARHGAP8 gene
Compartment Confidence
cytosol 4
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP8 Gene

Pathways & Interactions for ARHGAP8 Gene

genes like me logo Genes that share pathways with ARHGAP8: view

Pathways by source for ARHGAP8 Gene

1 BioSystems pathway for ARHGAP8 Gene
3 Reactome pathways for ARHGAP8 Gene

Interacting Proteins for ARHGAP8 Gene

Gene Ontology (GO) - Biological Process for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP8: view

No data available for SIGNOR curated interactions for ARHGAP8 Gene

Drugs & Compounds for ARHGAP8 Gene

No Compound Related Data Available

Transcripts for ARHGAP8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP8 Gene

No ASD Table

Relevant External Links for ARHGAP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP8 Gene

mRNA expression in normal human tissues for ARHGAP8 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP8 Gene

This gene is overexpressed in Spleen (x9.4), Kidney - Cortex (x7.3), and Thyroid (x4.5).

Protein differential expression in normal tissues from HIPED for ARHGAP8 Gene

This gene is overexpressed in Ovary (22.4), Prostate (19.0), and Testis (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP8 Gene

mRNA Expression by UniProt/SwissProt for ARHGAP8 Gene

Tissue specificity: Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined.
genes like me logo Genes that share expression patterns with ARHGAP8: view

Protein tissue co-expression partners for ARHGAP8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGAP8 Gene

Orthologs for ARHGAP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ARHGAP8 35
  • 85.28 (n)
  • 85.85 (a)
  • 71 (a)
(Mus musculus)
Mammalia Arhgap8 35
  • 84.1 (n)
  • 86.67 (a)
Arhgap8 36
  • 82 (a)
(Pan troglodytes)
Mammalia ARHGAP8 35
  • 92.99 (n)
  • 90.53 (a)
(Rattus norvegicus)
Mammalia Arhgap8 35
  • 84.19 (n)
  • 86.15 (a)
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Gallus gallus)
Aves ARHGAP8 35
  • 69.26 (n)
  • 75.65 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap8 35
  • 68.39 (n)
  • 68.91 (a)
Str.17718 35
African clawed frog
(Xenopus laevis)
Amphibia arhgap8-prov 35
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 37
  • 34 (a)
RhoGAP68F 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea W02B12.8 37
  • 36 (a)
rga-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for ARHGAP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ARHGAP8 Gene

Gene Tree for ARHGAP8 (if available)
Gene Tree for ARHGAP8 (if available)

Paralogs for ARHGAP8 Gene

genes like me logo Genes that share paralogs with ARHGAP8: view

Variants for ARHGAP8 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_049138 -
VAR_049139 -
VAR_049140 -
VAR_061182 -

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP8 Gene

Variant ID Type Subtype PubMed ID
dgv1410e1 CNV Complex 17122850
nsv829268 CNV Gain 20364138
nsv915285 CNV Loss 21882294
nsv915286 CNV Loss 21882294
essv12753 CNV CNV 17122850
esv2673983 CNV Deletion 23128226
nsv915287 CNV Loss 21882294
nsv459901 CNV Gain 19166990
nsv471208 CNV Gain 18288195
esv2724370 CNV Deletion 23290073
esv2667102 CNV Deletion 23128226
esv2724371 CNV Deletion 23290073
esv2259848 CNV Deletion 18987734
esv1192293 CNV Deletion 17803354
esv2663583 CNV Deletion 23128226
nsv459902 CNV Loss 19166990
nsv915288 CNV Loss 21882294
esv2724372 CNV Deletion 23290073
esv2512679 CNV Deletion 19546169
esv2724374 CNV Deletion 23290073
esv2658024 CNV Deletion 23128226
esv2674450 CNV Deletion 23128226

Variation tolerance for ARHGAP8 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP8 Gene

Disorders for ARHGAP8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cancer of cervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGAP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP8 Gene

Publications for ARHGAP8 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. (PMID: 20179103) Pan C.Q. … Low B.C. (J. Cell. Sci. 2010) 3 23
  3. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. (PMID: 15944398) Lua B.L. … Low B.C. (J. Cell. Sci. 2005) 3 23
  4. Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8. (PMID: 12559566) Shan Z. … Popescu N.C. (Gene 2003) 3 23
  5. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. (PMID: 12944407) Shang X. … Low B.C. (J. Biol. Chem. 2003) 3 23

Products for ARHGAP8 Gene

Sources for ARHGAP8 Gene