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Aliases for ARHGAP6 Gene

Aliases for ARHGAP6 Gene

  • Rho GTPase Activating Protein 6 2 3
  • Rho-Type GTPase-Activating Protein RhoGAPX-1 3 4
  • Rho-Type GTPase-Activating Protein 6 3 4
  • RHOGAP6 3 4
  • Rho GTPase-Activating Protein 6 3
  • RHOGAPX-1 3

External Ids for ARHGAP6 Gene

Previous GeneCards Identifiers for ARHGAP6 Gene

  • GC0XM010134
  • GC0XM009921
  • GC0XM010452
  • GC0XM010517
  • GC0XM010915
  • GC0XM011065
  • GC0XM011155
  • GC0XM008936

Summaries for ARHGAP6 Gene

Entrez Gene Summary for ARHGAP6 Gene

  • This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP6 Gene

ARHGAP6 (Rho GTPase Activating Protein 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP6 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP6 Gene

Genomics for ARHGAP6 Gene

Regulatory Elements for ARHGAP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP6 Gene

Start:
11,137,543 bp from pter
End:
11,665,701 bp from pter
Size:
528,159 bases
Orientation:
Minus strand

Genomic View for ARHGAP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP6 Gene

Proteins for ARHGAP6 Gene

  • Protein details for ARHGAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43182-RHG06_HUMAN
    Recommended name:
    Rho GTPase-activating protein 6
    Protein Accession:
    O43182
    Secondary Accessions:
    • B2RWQ0
    • O43437
    • Q9P1B3
    • Q9UK81
    • Q9UK82

    Protein attributes for ARHGAP6 Gene

    Size:
    974 amino acids
    Molecular mass:
    105947 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ARHGAP6 gene undergoes X inactivation

    Alternative splice isoforms for ARHGAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP6 Gene

Proteomics data for ARHGAP6 Gene at MOPED

Post-translational modifications for ARHGAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP6 Gene

No data available for DME Specific Peptides for ARHGAP6 Gene

Domains for ARHGAP6 Gene

Gene Families for ARHGAP6 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP6 Gene

Graphical View of Domain Structure for InterPro Entry

O43182

UniProtKB/Swiss-Prot:

RHG06_HUMAN :
  • O43182
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP6: view

Function for ARHGAP6 Gene

Molecular function for ARHGAP6 Gene

GENATLAS Biochemistry: Rho GTPase activating protein 6,aplysia related,involved in signal transduction
UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.

Gene Ontology (GO) - Molecular Function for ARHGAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8570618
GO:0005096 GTPase activator activity IEA --
GO:0016004 phospholipase activator activity IDA 18434237
GO:0017124 SH3 domain binding IEA --
GO:0043274 phospholipase binding IPI 18434237
genes like me logo Genes that share ontologies with ARHGAP6: view

Phenotypes for ARHGAP6 Gene

genes like me logo Genes that share phenotypes with ARHGAP6: view

Animal Models for ARHGAP6 Gene

MGI Knock Outs for ARHGAP6:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP6 Gene

Localization for ARHGAP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP6 Gene COMPARTMENTS Subcellular localization image for ARHGAP6 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
mitochondrion 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IMP 10699171
GO:0005829 cytosol TAS --
GO:0005884 actin filament NAS 10699171
GO:0015629 actin cytoskeleton ISS 10699171
genes like me logo Genes that share ontologies with ARHGAP6: view

Pathways for ARHGAP6 Gene

genes like me logo Genes that share pathways with ARHGAP6: view

Pathways by source for ARHGAP6 Gene

1 BioSystems pathway for ARHGAP6 Gene
3 Reactome pathways for ARHGAP6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ARHGAP6 Gene

Gene Ontology (GO) - Biological Process for ARHGAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization --
GO:0007165 signal transduction --
GO:0007202 activation of phospholipase C activity IDA 18434237
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction NAS 10699171
genes like me logo Genes that share ontologies with ARHGAP6: view

Transcripts for ARHGAP6 Gene

Unigene Clusters for ARHGAP6 Gene

Rho GTPase activating protein 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for ARHGAP6 Gene

GeneLoc Exon Structure for
ARHGAP6
ECgene alternative splicing isoforms for
ARHGAP6

Expression for ARHGAP6 Gene

mRNA expression in normal human tissues for ARHGAP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP6 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP6 Gene Hs.435291

mRNA Expression by UniProt/SwissProt for ARHGAP6 Gene

O43182-RHG06_HUMAN
Tissue specificity: Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver
genes like me logo Genes that share expressions with ARHGAP6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGAP6 Gene

Orthologs for ARHGAP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP6 35
  • 99.66 (n)
  • 99.49 (a)
ARHGAP6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP6 35
  • 86.49 (n)
  • 86.8 (a)
ARHGAP6 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP6 35
  • 86.71 (n)
  • 86.82 (a)
ARHGAP6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap6 35
  • 84.88 (n)
  • 85.39 (a)
Arhgap6 16
Arhgap6 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP6 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP6 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap6 35
  • 84.48 (n)
  • 84.48 (a)
chicken
(Gallus gallus)
Aves ARHGAP6 35
  • 71.51 (n)
  • 72.54 (a)
ARHGAP6 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP6 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap6 35
  • 66.97 (n)
  • 70.82 (a)
Str.14575 35
zebrafish
(Danio rerio)
Actinopterygii ARHGAP6 36
  • 56 (a)
OneToOne
LOC101882360 35
  • 59.84 (n)
  • 59.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP102A 36
  • 18 (a)
OneToMany
RhoGAP102A 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea rga-6 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 14 (a)
OneToMany
SAC7 38
Species with no ortholog for ARHGAP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP6 Gene

ENSEMBL:
Gene Tree for ARHGAP6 (if available)
TreeFam:
Gene Tree for ARHGAP6 (if available)

Paralogs for ARHGAP6 Gene

Selected SIMAP similar genes for ARHGAP6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARHGAP6: view

Variants for ARHGAP6 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs15615 -- 11,137,642(+) GTTTT(A/T)TAAAA utr-variant-3-prime, nc-transcript-variant
rs720061 -- 11,157,152(-) TGTAC(A/G)TTGTC intron-variant
rs720062 -- 11,156,679(-) CATAT(G/T)TTGCC intron-variant
rs739843 -- 11,171,895(-) GGGAC(A/C)TGCGA intron-variant
rs764452 -- 11,270,831(+) CCCCA(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP6 Gene

Variant ID Type Subtype PubMed ID
nsv515163 CNV Loss 21397061
esv2739963 CNV Deletion 23290073
esv270995 CNV Insertion 20981092
nsv6797 CNV Loss 18451855
esv271693 CNV Insertion 20981092

Relevant External Links for ARHGAP6 Gene

HapMap Linkage Disequilibrium report
ARHGAP6
Human Gene Mutation Database (HGMD)
ARHGAP6
Locus Specific Mutation Databases (LSDB)
ARHGAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP6 Gene

Disorders for ARHGAP6 Gene

(2) University of Copenhagen DISEASES for ARHGAP6 Gene

(1) Novoseek inferred disease relationships for ARHGAP6 Gene

Disease -log(P) Hits PubMed IDs
microphthalmia 80.2 1

Relevant External Links for ARHGAP6

Genetic Association Database (GAD)
ARHGAP6
Human Genome Epidemiology (HuGE) Navigator
ARHGAP6
genes like me logo Genes that share disorders with ARHGAP6: view

No data available for UniProtKB/Swiss-Prot for ARHGAP6 Gene

Publications for ARHGAP6 Gene

  1. Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. (PMID: 9417914) Schaefer L. … Zoghbi H.Y. (Genomics 1997) 2 3 4 23
  2. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. (PMID: 10699171) Prakash S.K. … Zoghbi H.Y. (Hum. Mol. Genet. 2000) 3 4 23
  3. Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension. (PMID: 18434237) Ochocka A.M. … Pawelczyk T. (Int. J. Biochem. Cell Biol. 2008) 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for ARHGAP6 Gene

Sources for ARHGAP6 Gene

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