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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP6 Gene

protein-coding   GIFtS: 61
GCID: GC0XM011155

Rho GTPase activating protein 6
 Explore 4 diseases affiliated with
ARHGAP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGAP6    

Aliases
for ARHGAP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho GTPase Activating Protein 61 2     RhoGAPX-11
Rho-Type GTPase-Activating Protein 62 3     RHOGAPX-12
RHOGAP62 3     Rho GTPase-Activating Protein 62
Rho-Type GTPase-Activating Protein RhoGAPX-12 3     

External Ids:    HGNC: 6761   Entrez Gene: 3952   Ensembl: ENSG000000476487   OMIM: 3001185   UniProtKB: O431823   

Export aliases for ARHGAP6 gene to outside databases

Previous GC identifers: GC0XM010134 GC0XM009921 GC0XM010452 GC0XM010517 GC0XM010915 GC0XM011065 GC0XM008936


Summaries
for ARHGAP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGAP6:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization
at the plasma membrane during several cellular processes. This protein is thought to have two independent functions,
one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes
actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RHG06_HUMAN, O43182
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate
the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic
processes during cell motility and simultaneous retraction of the cell body changing the cell morphology




Genomic Views
for ARHGAP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP6 gene promoter:
         TBP   CREB   HSF2   TFIID   deltaCREB   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.3

ARHGAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM011155:  view genomic region     (about GC identifiers)

Start:
 11,136,239 bp from pter      End:
 11,683,821 bp from pter
Size:
 547,583 bases      Orientation:
 minus strand

Proteins
for ARHGAP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHG06_HUMAN, O43182 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 6  
Size: 974 amino acids; 105947 Da
Subcellular location: Cytoplasm
Miscellaneous: ARHGAP6 gene undergoes X inactivation
Secondary accessions: B2RWQ0 O43437 Q9P1B3 Q9UK81 Q9UK82
Alternative splicing: 5 isoforms:  O43182-1   O43182-2   O43182-3   O43182-4   O43182-5   

Explore the universe of human proteins at neXtProt for ARHGAP6: NX_O43182

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43182

    • ARHGAP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_006116.2  NP_038267.1  NP_038286.2  

    ENSEMBL proteins: 
     ENSP00000370112   ENSP00000302312   ENSP00000338967   ENSP00000435767   ENSP00000370093  
     ENSP00000370094   ENSP00000438135   ENSP00000370108   ENSP00000389394  
    Reactome Protein details: O43182
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    Uscn Proteins for ARHGAP6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IMP10699171
    GO:0005829cytosol TAS--
    GO:0005884actin filament NAS10699171
    GO:0015629actin cytoskeleton ISS10699171


    ARHGAP6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARHGAP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGAP6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O43182

    ProtoNet protein and cluster: O43182

    1 Blocks protein family: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG06_HUMAN, O43182
    Similarity: Contains 1 Rho-GAP domain


    Function
    for ARHGAP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHG06_HUMAN, O43182
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate
    the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic
    processes during cell motility and simultaneous retraction of the cell body changing the cell morphology

         Genatlas biochemistry entry for ARHGAP6:
    Rho GTPase activating protein 6,aplysia related,involved in signal transduction

    miRNA
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    Gene Editing
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8570618
    GO:0005100Rho GTPase activator activity ISS10699171
    GO:0016004phospholipase activator activity IDA18434237
    GO:0017124SH3 domain binding IEA--
    GO:0043274phospholipase binding IPI18434237


    ARHGAP6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARHGAP6:
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Arhgap6tm1Hzo for ARHGAP6
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Arhgap6):
     embryogenesis  growth/size  mortality/aging  normal 

    ARHGAP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARHGAP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    2Regulation of RhoA activity
    		Regulation of RhoA activity1.00
    3Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ARHGAP6 
        Regulation of RhoA activity

    3        Reactome Pathways for ARHGAP6
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for ARHGAP6 (ENSP000003389674) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMOTENSP000003610274STRING: ENSP00000361027
    RAC3ENSP000003042834STRING: ENSP00000304283
    ACTA1ENSP000003556454STRING: ENSP00000355645
    ACTC1ENSP000002903784STRING: ENSP00000290378
    CD2APENSP000003522644STRING: ENSP00000352264
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ----
    GO:0007165signal transduction ----
    GO:0007202activation of phospholipase C activity IDA18434237
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction NAS10699171


    ARHGAP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGAP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP6
    Search CenterWatch for drugs/clinical trials and news about ARHGAP6 / RHG06 

    Transcripts
    for ARHGAP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGAP6 gene (5 alternative transcripts): 
    NM_006125.2  NM_013423.2  NM_013427.2  NM_001174.3  NM_013422.2  

    Unigene Cluster for ARHGAP6:

    Rho GTPase activating protein 6
    Hs.435291  [show with all ESTs]
    Unigene Representative Sequence: AB208792
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380736(uc004cun.1) ENST00000303025(uc004cum.1) ENST00000337414(uc004cup.1)
    ENST00000495242(uc004cuo.1) ENST00000489330 ENST00000380717(uc010neb.1)
    ENST00000380718(uc004cur.1) ENST00000491514 ENST00000534860 ENST00000380732
    ENST00000413512(uc011mif.1)

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    hsa-miR-656 hsa-miR-135b hsa-miR-369-3p hsa-miR-1271 hsa-miR-145 hsa-miR-96 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ARHGAP6 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB208792.1 AF012272.2 AF022212.2 AF117067.1 AF177663.1 AF177665.1 AK293078.1 AK297713.1 
    AK297747.1 AK303444.1 BC035785.1 BC150635.1 

    10 DOTS entries:

    DT.91744947  DT.107093  DT.121305062  DT.95370974  DT.97799910  DT.102741  DT.91744951  DT.95370975 
    DT.91744952  DT.121305049 

    24/59 AceView cDNA sequences (see all 59):

    BQ930645 AI633703 AI288251 AI377079 BG214964 BG190139 BG202905 NM_013422 
    AF177665 NM_013423 BG207569 BG211238 CF140353 BE645442 BM543771 NM_006125 
    AL047218 AA495981 NM_013427 CB045087 BF221642 AF117067 AI433854 BG181711 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP6 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:              -                                                     -                       -               
    SP2:        -     -                                                     -           -           -               
    SP3:                                                                    -           -           -               
    SP4:        -     -                                                     -           -                           
    SP5:              -                                                     -           -                           


    ECgene alternative splicing isoforms for ARHGAP6

    Expression
    for ARHGAP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGAATAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARHGAP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Embryoid bodies (Two-step protocol fo...)

    See ARHGAP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP6

    SOURCE GeneReport for Unigene cluster: Hs.435291

    UniProtKB/Swiss-Prot: RHG06_HUMAN, O43182
    Tissue specificity: Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta,
    lung, brain, pancreas and liver

        SABiosciences Expression via Pathway-Focused PCR Array including ARHGAP6: 
              Cytoskeleton Regulators in human mouse rat

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    Orthologs
    for ARHGAP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP6 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARHGAP61 Rho GTPase activating protein 6 72.74(n)
    74.14(a)    		   418642  XM_416840.3  XP_416840.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGAP66
    		 --
    		 76(a)
    		 1 ↔ 1
    		 3(119453243-119495559)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.145752 Transcribed sequence with moderate similarity to protein more 80.83(n)    BX701330.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1367631 zgc:136763 56.14(n)
    56.54(a)    		   559813  NM_001044906.1  NP_001038371.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RhoGAP102A3 Rho GTPase activator 47(a)   102B3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea rga-66
    		 Protein RGA-6, isoform a
    		 18(a)
    		 1 → many
    		 I(4850683-4867826)


    ENSEMBL Gene Tree for ARHGAP6 (if available)
    TreeFam Gene Tree for ARHGAP6 (if available) 

    Paralogs
    for ARHGAP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP6 gene
    ARHGAP362  STARD132  ARHGAP402  ARHGAP182  ARHGAP11A2  DLC12  ARHGAP282  ARHGAP11B2  
    STARD82  
    4 SIMAP similar genes for ARHGAP6 using alignment to 4 protein entries:     RHG06_HUMAN (see all proteins):
    ARHGAP21    ARHGAP12    ARHGAP36    FAM13A

    ARHGAP6 for paralogs           About GeneDecksing



    Genomic Variants
    for ARHGAP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5630 NCBI SNPs in ARHGAP6 are shown (see all 5630)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1872052551,2
    		--11155335(+) GTGTAC/GCTTAA 2 -- ds50010--------
    rs414715491,2
    		C,F,H,--11155336(-) GTTAAG/ACTACA 2 -- ds500119Minor allele frequency- A:0.04NS EA NA 2306
    rs59338621,2
    		C,F,H,--11155729(+) TTTCAT/ACACCA 2 -- ut3116Minor allele frequency- A:0.17NS EA NA WA CSA 1969
    rs156151,2
    		F--11155762(+) GTTTTA/TTAAAA 2 -- ut311Minor allele frequency- T:0.04MN 184
    rs114165961,2
    		C,--11155811(+) AAGTG-/AAAAAA 2 -- ut310--------
    rs32074281,2
    		F--11155847(-) GCAGAT/AGGCGA 2 -- ut31 ese31Minor allele frequency- A:0.02MN 184
    rs1905767871,2
    		--11155851(+) CATCTG/TCTGGT 2 -- ut310--------
    rs22856651,2
    		C,H--11155885(+) AACTTC/TAAACT 2 -- ut31 ese35Minor allele frequency- T:0.00NS EA NA 420
    rs413031751,2
    		C,--11156292(+) TTCTAA/GANNNN 2 -- ut310--------
    rs1831094891,2
    		--11156304(+) ATTTCA/GTAATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGAP6 (11136239 - 11386239 bp, first 250kb of ARHGAP6)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ARHGAP6
         2 CNVs: 83344 96483
    Human Gene Mutation Database (HGMD): ARHGAP6

    Locus Specific Mutation Databases (LSDB): ARHGAP6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP6
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP6

    Disorders / Diseases
    for ARHGAP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGAP6 for disorders           About GeneDecksing

    OMIM gene information: 300118    OMIM disorders: --

    4 diseases for ARHGAP6:    About MalaCards
    microphthalmia with linear skin defects    x inactivation    microphthalmia    hypertension

    2 diseases from the University of Copenhagen DISEASES database for ARHGAP6:
    Microphthalmia     Amelogenesis imperfecta

    1 Novoseek disease relationship for ARHGAP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microphthalmia 80.2 1 9417914 (1)

    Human Genome Epidemiology (HuGE) Navigator: ARHGAP6 (3 documents)

    Export disorders for ARHGAP6 gene to outside databases

    Publications
    for ARHGAP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP6 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ARHGAP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. (PubMed id 9417914)1, 2, 3, 9 Schaefer L.... Zoghbi H.Y. (1997)
    2. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. (PubMed id 10699171)1, 2, 9 Prakash S.K.... Zoghbi H.Y. (2000)
    3. Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension. (PubMed id 18434237)1, 9 Ochocka A.M....Pawelczyk T. (2008)
    4. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Identification of Rho GTPase activating protein 6 iso form 1 variant as a new molecular marker in human colorectal tumors. (PubMed id 19960375)1 Guo F....Li G. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for ARHGAP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARHGAP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 395 HGNC: 676 AceView: ARHGAP6 Ensembl:ENSG00000047648 euGenes: HUgn395
    ECgene: ARHGAP6 H-InvDB: ARHGAP6

    Other Databases showing ARHGAP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARHGAP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGAP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ARHGAP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGAP6 gene:
    Search GeneIP for patents involving ARHGAP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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