Aliases for ARHGAP6 Gene
External Ids for ARHGAP6 Gene
Previous GeneCards Identifiers for ARHGAP6 Gene
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGAP6 Gene
ARHGAP6 (Rho GTPase Activating Protein 6) is a Protein Coding gene. Diseases associated with ARHGAP6 include sclerocornea and amelogenesis imperfecta. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is ARHGAP11A.
UniProtKB/Swiss-Prot for ARHGAP6 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.