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Aliases for ARHGAP5 Gene

Aliases for ARHGAP5 Gene

  • Rho GTPase Activating Protein 5 2 3 5
  • Rho-Type GTPase-Activating Protein 5 3 4
  • Growth Factor Independent 2 2 3
  • RhoGAP5 3 4
  • P190-B 3 4
  • P100 RasGAP-Associated P105 Protein 3
  • Rho GTPase-Activating Protein 5 3
  • P105 RhoGAP 3
  • P190BRhoGAP 3
  • GFI2 3

External Ids for ARHGAP5 Gene

Previous HGNC Symbols for ARHGAP5 Gene

  • GFI2

Previous GeneCards Identifiers for ARHGAP5 Gene

  • GC14P030000
  • GC14P026333
  • GC14P030536
  • GC14P031615
  • GC14P032546
  • GC14P012663

Summaries for ARHGAP5 Gene

Entrez Gene Summary for ARHGAP5 Gene

  • Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP5 Gene

ARHGAP5 (Rho GTPase Activating Protein 5) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Regulation of RhoA activity. GO annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is ARHGAP35.

UniProtKB/Swiss-Prot for ARHGAP5 Gene

  • GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.

Gene Wiki entry for ARHGAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP5 Gene

Genomics for ARHGAP5 Gene

Regulatory Elements for ARHGAP5 Gene

Enhancers for ARHGAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F032251 1.2 Ensembl ENCODE 12 +176.0 176013 0.9 ARID4B ZNF48 ZNF2 SLC30A9 ZNF143 DEK MXD4 MIER2 REST PPARG ARHGAP5 LOC100533787 LOC644295
GH14F032101 1 Ensembl ENCODE 12.4 +26.3 26278 1.2 PKNOX1 MTA2 FEZF1 ZEB2 TBX21 ZNF843 EP300 OSR2 ZNF121 ZNF316 ARHGAP5 RNU6-7 RNU6-8 ARHGAP5-AS1 GC14P032154
GH14F031204 1.2 ENCODE 9.7 -868.8 -868824 5.1 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RPL21P5 UBE2CP1 ARHGAP5 HEATR5A DTD2 HECTD1 RNU6-541P
GH14F032224 1 Ensembl ENCODE 10.8 +149.2 149249 1.1 CTCF ZNF644 RAD21 GATA3 PATZ1 ZNF143 ZNF600 FOSL2 FOS ZBTB20 RNU6-7 RNU6-8 ARHGAP5 LOC100533787
GH14F032134 1 ENCODE 10.7 +58.7 58746 0.1 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 FOS ZNF263 LOC100533787 ENSG00000257472 ENSG00000258196 ENSG00000257155 RNU6-7 RNU6-8 ARHGAP5 DTD2 GC14P032154 ARHGAP5-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000416069 1286 4801 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF263

Genomic Location for ARHGAP5 Gene

Chromosome:
14
Start:
32,076,114 bp from pter
End:
32,159,728 bp from pter
Size:
83,615 bases
Orientation:
Plus strand

Genomic View for ARHGAP5 Gene

Genes around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP5 Gene

Proteins for ARHGAP5 Gene

  • Protein details for ARHGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13017-RHG05_HUMAN
    Recommended name:
    Rho GTPase-activating protein 5
    Protein Accession:
    Q13017
    Secondary Accessions:
    • A1L375
    • A1L376
    • A8KAA1
    • D3DS89
    • D3DS90
    • Q05BE8
    • Q05BU8
    • Q59ER0
    • Q6DHZ3

    Protein attributes for ARHGAP5 Gene

    Size:
    1502 amino acids
    Molecular mass:
    172460 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA95963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH32723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP5 Gene

    Alternative splice isoforms for ARHGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP5 Gene

Post-translational modifications for ARHGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARHGAP5 (ARHGAP5)

No data available for DME Specific Peptides for ARHGAP5 Gene

Domains & Families for ARHGAP5 Gene

Gene Families for ARHGAP5 Gene

Suggested Antigen Peptide Sequences for ARHGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13017

UniProtKB/Swiss-Prot:

RHG05_HUMAN :
  • Contains 4 FF domains.
Domain:
  • Contains 4 FF domains.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP5: view

Function for ARHGAP5 Gene

Molecular function for ARHGAP5 Gene

GENATLAS Biochemistry:
Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm
UniProtKB/Swiss-Prot Function:
GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.

Gene Ontology (GO) - Molecular Function for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8537347
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 23622247
GO:0005525 GTP binding IEA --
GO:0042169 SH2 domain binding IPI 1689011
genes like me logo Genes that share ontologies with ARHGAP5: view
genes like me logo Genes that share phenotypes with ARHGAP5: view

Animal Models for ARHGAP5 Gene

MGI Knock Outs for ARHGAP5:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP5 Gene

Localization for ARHGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP5 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,TAS --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Pathways & Interactions for ARHGAP5 Gene

genes like me logo Genes that share pathways with ARHGAP5: view

Pathways by source for ARHGAP5 Gene

1 GeneTex pathway for ARHGAP5 Gene
1 Cell Signaling Technology pathway for ARHGAP5 Gene
3 BioSystems pathways for ARHGAP5 Gene
3 Reactome pathways for ARHGAP5 Gene

SIGNOR curated interactions for ARHGAP5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8537347
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 8537347
GO:0030879 mammary gland development IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Transcripts for ARHGAP5 Gene

Unigene Clusters for ARHGAP5 Gene

Rho GTPase activating protein 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:
SP2: - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6:

Relevant External Links for ARHGAP5 Gene

GeneLoc Exon Structure for
ARHGAP5
ECgene alternative splicing isoforms for
ARHGAP5

Expression for ARHGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP5 Gene

This gene is overexpressed in Serum (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP5 Gene



Protein tissue co-expression partners for ARHGAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP5 Gene:

ARHGAP5

SOURCE GeneReport for Unigene cluster for ARHGAP5 Gene:

Hs.592313

mRNA Expression by UniProt/SwissProt for ARHGAP5 Gene:

Q13017-RHG05_HUMAN
Tissue specificity: Expressed in kidney, brain, liver and lung.
genes like me logo Genes that share expression patterns with ARHGAP5: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGAP5 Gene

Orthologs for ARHGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP5 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia ARHGAP5 34 35
  • 95.25 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP5 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP5 34 35
  • 93.75 (n)
mouse
(Mus musculus)
Mammalia Arhgap5 34 16 35
  • 93.54 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap5 34
  • 93.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP5 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP5 34 35
  • 83.98 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP5 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap5 34
  • 74.97 (n)
Str.9761 34
zebrafish
(Danio rerio)
Actinopterygii arhgap5 34 35
  • 68.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36 35
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea rga-5 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
Species where no ortholog for ARHGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP5 Gene

ENSEMBL:
Gene Tree for ARHGAP5 (if available)
TreeFam:
Gene Tree for ARHGAP5 (if available)

Paralogs for ARHGAP5 Gene

Paralogs for ARHGAP5 Gene

Pseudogenes.org Pseudogenes for ARHGAP5 Gene

genes like me logo Genes that share paralogs with ARHGAP5: view

Variants for ARHGAP5 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10134888 -- 32,099,649(+) CCTCA(A/T)TATAC intron-variant
rs10143850 -- 32,107,460(+) CTGGT(C/G)CCTGT intron-variant
rs1044832 -- 32,075,503(-) TTTAC(A/G)GTCTG nc-transcript-variant, upstream-variant-2KB
rs1065474 -- 32,101,545(+) CGTGC(C/T)TTTTG intron-variant
rs111262766 -- 32,143,244(+) TTATT(-/GTT)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP5 Gene

Variant ID Type Subtype PubMed ID
nsv974323 CNV duplication 23825009
nsv974322 CNV duplication 23825009
nsv832764 CNV gain 17160897
nsv564182 CNV gain 21841781
nsv1046526 CNV gain 25217958
esv3584226 CNV gain 25503493

Variation tolerance for ARHGAP5 Gene

Residual Variation Intolerance Score: 4.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP5 Gene

Human Gene Mutation Database (HGMD)
ARHGAP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Disorders for ARHGAP5 Gene

Relevant External Links for ARHGAP5

Genetic Association Database (GAD)
ARHGAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP5

No disorders were found for ARHGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP5 Gene

Publications for ARHGAP5 Gene

  1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PMID: 8537347) Burbelo P.D. … Yamada Y. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PMID: 10939588) Chakravarty G. … Rosen J.M. (Cell Growth Differ. 2000) 3 22 64
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64

Products for ARHGAP5 Gene

Sources for ARHGAP5 Gene

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