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ARHGAP5 Gene

protein-coding   GIFtS: 63
GCID: GC14P032546

Rho GTPase Activating Protein 5

(Previous name: growth factor independent 2)
(Previous symbol: GFI2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 51 2     RhoGAP52
GFI21 2     P100 RasGAP-Associated P105 Protein2
Growth Factor Independent 21 2     P105 RhoGAP2
Rho-Type GTPase-Activating Protein 52 3     p190BRhoGAP2
p190-B2 3     Rho GTPase-Activating Protein 52
RHOGAP53 5     

External Ids:    HGNC: 6751   Entrez Gene: 3942   Ensembl: ENSG000001008527   OMIM: 6026805   UniProtKB: Q130173   

Export aliases for ARHGAP5 gene to outside databases

Previous GC identifers: GC14P030000 GC14P026333 GC14P030536 GC14P031615 GC14P012663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP5 Gene:
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes
by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGAP5 Gene:
ARHGAP5 (Rho GTPase activating protein 5) is a protein-coding gene. GO annotations related to this gene include SH2 domain binding and GTP binding. An important paralog of this gene is ARHGAP17.

UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
Function: GTPase-activating protein for Rho family members. May play a role in the reduction of the
p21rasGTPase-activating potential of RASA1/p120GAP

Gene Wiki entry for ARHGAP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP5 gene promoter:
         CREB   LHX3b/Lhx3b   STAT1   Nkx2-2   deltaCREB   Pax-4a   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP5 promoter sequence
   Search Chromatin IP Primers for ARHGAP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P032546:  view genomic region     (about GC identifiers)

Start:
32,545,320 bp from pter      End:
32,628,934 bp from pter
Size:
83,615 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 5  
Size: 1502 amino acids; 172460 Da
Sequence caution: Sequence=AAA95963.1; Type=Frameshift; Positions=Several; Sequence=AAH32723.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from and Proteopedia for ARHGAP5:
2EE4 (3D)        2EE5 (3D)    
Secondary accessions: A1L375 A1L376 A8KAA1 D3DS89 D3DS90 Q05BE8 Q05BU8 Q59ER0 Q6DHZ3
Alternative splicing: 4 isoforms:  Q13017-1   Q13017-2   Q13017-3   Q13017-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP5: NX_Q13017

Explore proteomics data for ARHGAP5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025226.1  NP_001164.2  

    ENSEMBL proteins: 
     ENSP00000452372   ENSP00000452222   ENSP00000441692   ENSP00000379827   ENSP00000407395  
     ENSP00000451579   ENSP00000451061   ENSP00000452606   ENSP00000371897   ENSP00000393307  
    Reactome Protein details: Q13017

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    antibodies-online peptides for ARHGAP5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR002713 FF_domain
     IPR008936 Rho_GTPase_activation_prot
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q13017

    ProtoNet protein and cluster: Q13017

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB002713 FF domain


    UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
    Similarity: Contains 4 FF domains
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG05_HUMAN, Q13017
    Function: GTPase-activating protein for Rho family members. May play a role in the reduction of the
    p21rasGTPase-activating potential of RASA1/p120GAP

         Genatlas biochemistry entry for ARHGAP5:
    Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8537347
    GO:0005100Rho GTPase activator activity TAS8537347
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0042169SH2 domain binding IPI1689011
         
    Find genes that share ontologies with ARHGAP5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP5:
     Decreased focal adhesion (FA)   Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap5):
     adipose tissue  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     integument  mortality/aging  nervous system  respiratory system 

    Find genes that share phenotypes with ARHGAP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgap5tm1Jset for ARHGAP5

       genOway: Develop your customized and physiologically relevant rodent model for ARHGAP5

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    Block miRNA regulation of human, mouse, rat ARHGAP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP5 (see all 131):
    hsa-miR-376b hsa-miR-3653 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p hsa-miR-374b* hsa-miR-186* hsa-miR-130a*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG05_HUMAN, Q13017: Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found
    in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS8537347
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with ARHGAP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP5 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    3GPCR Pathway
    Ras Pathway0.73
    4Signaling by GPCR
    Signal Transduction0.58
    5Integrin Pathway
    Transendothelial Migration of Leukocytes0.38


    Find genes that share SuperPaths with ARHGAP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGAP5
        RhoA Pathway
    G12-G13 in Cellular Signaling
    RhoGDI Pathway
    Transendothelial Migration of Leukocytes
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for ARHGAP5
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for ARHGAP5
        G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Regulation of CDC42 activity

    3 BioSystems Pathways for ARHGAP5
        Focal Adhesion
    Regulation of RhoA activity
    RAC1 signaling pathway

    1 Reactome Pathway for ARHGAP5
        Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARHGAP5):
        Focal adhesion
    Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARHGAP5: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGAP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP5 (Q130171, 2, 3 ENSP000003718974) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61793 I2D: score=4 
    RASA1P209363, ENSP000002743764I2D: score=3 STRING: ENSP00000274376
    PTK2BQ142893, ENSP000003328164I2D: score=2 STRING: ENSP00000332816
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0006184GTP catabolic process TAS8537347
    GO:0007155cell adhesion TAS8537347
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGAP5 (RHG05)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP5 gene (2 alternative transcripts): 
    NM_001030055.1  NM_001173.2  

    Unigene Cluster for ARHGAP5:

    Rho GTPase activating protein 5
    Hs.592313  [show with all ESTs]
    Unigene Representative Sequence: NM_001030055
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555814 ENST00000556611 ENST00000539826 ENST00000396582 ENST00000433497
    ENST00000556191 ENST00000554090 ENST00000557643 ENST00000216743 ENST00000345122(uc001wrl.3 uc001wrn.3)
    ENST00000432921(uc001wrm.3 uc001wro.3 uc001wrp.3)
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    hsa-miR-376b hsa-miR-3653 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p hsa-miR-374b* hsa-miR-186* hsa-miR-130a*
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    Additional mRNA sequence: 

    AB209751.1 AK023014.1 AK023468.1 AK292966.1 AK307454.1 AY316523.1 BC032723.2 BC050059.1 
    BC075799.1 BC129928.1 BC129929.1 U17032.1 

    11 DOTS entries:

    DT.443531  DT.95138928  DT.97799782  DT.91915557  DT.101971713  DT.40120106  DT.100725656  DT.120787789 
    DT.92434681  DT.95330255  DT.91743594 

    Selected AceView cDNA sequences (see all 136):

    CA394541 BP349859 AL041694 AL042952 AW510501 R30764 BX486747 AU141217 
    BM127896 CB068360 AA329829 CB133879 BM712978 AI587378 AW295718 BC075799 
    AI650272 AL045112 AI570955 CR596496 BF438091 BE301781 CK430128 BC050059 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                                                                                                
    SP2:                                                  -     -                                       
    SP3:              -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                
    SP5:        -     -                                                                                 


    ECgene alternative splicing isoforms for ARHGAP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCAAAG
    ARHGAP5 Expression
    About this image


    ARHGAP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Thyroid (Endocrine System)
    ARHGAP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592313

    UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
    Tissue specificity: Expressed in kidney, brain, liver and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARHGAP5: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap51 , 5 Rho GTPase activating protein 51, 5 93.54(n)1
    97.4(a)1
      12 (22.16 cM)5
    118551  NM_009706.21  NP_033836.21 
     525160775 
    chicken
    (Gallus gallus)
    Aves ARHGAP51 Rho GTPase activating protein 5 83.98(n)
    91.41(a)
      428883  XM_426439.4  XP_426439.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP56
    Rho GTPase activating protein 5
    91(a)
    1 ↔ 1
    2(56415036-56451227)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851201.12   -- 72.92(n)    BX851201.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap51 Rho GTPase activating protein 5 68.31(n)
    74.08(a)
      795752  XM_001335980.2  XP_001336016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1903 mushroom body development Rho GTPase
    activator
    33(a)   16B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea rga-56
    Protein RGA-5, isoform a (rga-5) mRNA, complete cd...
    25(a)
    1 → many
    IV(13827886-13844978) WBGene00010374


    ENSEMBL Gene Tree for ARHGAP5 (if available)
    TreeFam Gene Tree for ARHGAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP5 gene
    ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP442  SH3BP12  
    ARHGAP252  SRGAP22  ARHGAP42  
    Selected SIMAP similar genes for ARHGAP5 using alignment to 6 protein entries:     RHG05_HUMAN (see all proteins) (see all similar genes):
    GRLF1    ARHGAP35    ARHGAP27    FAM13B    CHN1    CHN2
    MYO9A    ABR    ARHGAP21    ARHGAP4    MYO9B    ARHGAP1
    SH3BP1    ARHGAP12    ARHGAP44    ARHGAP24    ARHGAP42    ARHGAP9

    Find genes that share paralogs with ARHGAP5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ARHGAP5
    PGOHUM00000235374 PGOHUM00000233237


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP5 (see all 1521)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783375531,2
    Cuntested132561340(+) AAGAAG/AAGTTT 4 /K /E mis11Minor allele frequency- A:0.00EU 795
    rs1836291361,2
    --32548014(+) GGTTTA/GAAAAT 2 -- int10--------
    rs1902733781,2
    --32548103(+) TGTAGA/GTAAGT 2 -- int10--------
    rs1480501561,2
    --32548135(+) CTACTA/GGATAG 2 -- int10--------
    rs1932674481,2
    C--32548190(+) TTTTTC/GCTTTC 2 -- int10--------
    rs1181704821,2
    F--32548368(+) TATTGA/TTCTAA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs740415841,2
    C,F--32548601(+) AAACGG/ACCTTA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs794793811,2
    F--32548639(+) ATTACC/GTTAAT 2 -- int11Minor allele frequency- G:0.07NA 120
    rs1164967241,2
    C,F--32548947(+) TAAATA/GTGAAA 2 -- int11Minor allele frequency- G:0.13WA 118
    rs1161221341,2
    F--32549057(+) GTCCAC/TAGTTT 2 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ARHGAP5 (32545320 - 32628934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARHGAP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832764CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602680    OMIM disorders: --


    Find genes that share disorders with ARHGAP5           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP5

    Export disorders for ARHGAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP5 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with ARHGAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PubMed id 8537347)1, 2, 3, 9 Burbelo P.D....Yamada Y. (J. Biol. Chem. 1995)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2 Zhan X. and Desiderio D.M. (Anal. Biochem. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PubMed id 10939588)1, 9 Chakravarty G....Rosen J.M. (amp 2000)
    5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    6. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. (PubMed id 23552690)1 Ponik S.M....Keely P.J. (Mol. Biol. Cell 2013)
    7. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    8. Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability. (PubMed id 23653363)1 Zebda N....Birukov K.G. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 394 HGNC: 675 AceView: ARHGAP5 Ensembl:ENSG00000100852 euGenes: HUgn394
    ECgene: ARHGAP5 Kegg: 394 H-InvDB: ARHGAP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP5 gene:
    Search GeneIP for patents involving ARHGAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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