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Aliases for ARHGAP5 Gene

Aliases for ARHGAP5 Gene

  • Rho GTPase Activating Protein 5 2 3 5
  • Rho-Type GTPase-Activating Protein 5 3 4
  • Growth Factor Independent 2 2 3
  • RhoGAP5 3 4
  • P190-B 3 4
  • P100 RasGAP-Associated P105 Protein 3
  • P105 RhoGAP 3
  • P190BRhoGAP 3
  • GFI2 3

External Ids for ARHGAP5 Gene

Previous HGNC Symbols for ARHGAP5 Gene

  • GFI2

Previous GeneCards Identifiers for ARHGAP5 Gene

  • GC14P030000
  • GC14P026333
  • GC14P030536
  • GC14P031615
  • GC14P032546
  • GC14P012663

Summaries for ARHGAP5 Gene

Entrez Gene Summary for ARHGAP5 Gene

  • Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP5 Gene

ARHGAP5 (Rho GTPase Activating Protein 5) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and G-protein signaling_Cross-talk between Ras-family GTPases. GO annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is ARHGAP9.

UniProtKB/Swiss-Prot for ARHGAP5 Gene

  • GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.

Gene Wiki entry for ARHGAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP5 Gene

Genomics for ARHGAP5 Gene

Regulatory Elements for ARHGAP5 Gene

Enhancers for ARHGAP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP5 Gene

Chromosome:
14
Start:
32,076,114 bp from pter
End:
32,159,728 bp from pter
Size:
83,615 bases
Orientation:
Plus strand

Genomic View for ARHGAP5 Gene

Genes around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP5 Gene

Proteins for ARHGAP5 Gene

  • Protein details for ARHGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13017-RHG05_HUMAN
    Recommended name:
    Rho GTPase-activating protein 5
    Protein Accession:
    Q13017
    Secondary Accessions:
    • A1L375
    • A1L376
    • A8KAA1
    • D3DS89
    • D3DS90
    • Q05BE8
    • Q05BU8
    • Q59ER0
    • Q6DHZ3

    Protein attributes for ARHGAP5 Gene

    Size:
    1502 amino acids
    Molecular mass:
    172460 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA95963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH32723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP5 Gene

    Alternative splice isoforms for ARHGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP5 Gene

Proteomics data for ARHGAP5 Gene at MOPED

Post-translational modifications for ARHGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP5 Gene

Domains & Families for ARHGAP5 Gene

Gene Families for ARHGAP5 Gene

Suggested Antigen Peptide Sequences for ARHGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13017

UniProtKB/Swiss-Prot:

RHG05_HUMAN :
  • Contains 4 FF domains.
Domain:
  • Contains 4 FF domains.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP5: view

Function for ARHGAP5 Gene

Molecular function for ARHGAP5 Gene

GENATLAS Biochemistry:
Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm
UniProtKB/Swiss-Prot Function:
GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.

Gene Ontology (GO) - Molecular Function for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23622247
genes like me logo Genes that share ontologies with ARHGAP5: view
genes like me logo Genes that share phenotypes with ARHGAP5: view

Animal Models for ARHGAP5 Gene

MGI Knock Outs for ARHGAP5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP5 Gene

Localization for ARHGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP5 Gene COMPARTMENTS Subcellular localization image for ARHGAP5 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Pathways & Interactions for ARHGAP5 Gene

genes like me logo Genes that share pathways with ARHGAP5: view

Pathways by source for ARHGAP5 Gene

1 GeneTex pathway for ARHGAP5 Gene
1 Cell Signaling Technology pathway for ARHGAP5 Gene
3 BioSystems pathways for ARHGAP5 Gene
3 Reactome pathways for ARHGAP5 Gene

SIGNOR curated interactions for ARHGAP5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8537347
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030879 mammary gland development IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP5: view

Drugs & Compounds for ARHGAP5 Gene

No Compound Related Data Available

Transcripts for ARHGAP5 Gene

Unigene Clusters for ARHGAP5 Gene

Rho GTPase activating protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:
SP2: - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6:

Relevant External Links for ARHGAP5 Gene

GeneLoc Exon Structure for
ARHGAP5
ECgene alternative splicing isoforms for
ARHGAP5

Expression for ARHGAP5 Gene

mRNA expression in normal human tissues for ARHGAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP5 Gene

This gene is overexpressed in Serum (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP5 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP5 Gene Hs.592313

mRNA Expression by UniProt/SwissProt for ARHGAP5 Gene

Q13017-RHG05_HUMAN
Tissue specificity: Expressed in kidney, brain, liver and lung.
genes like me logo Genes that share expression patterns with ARHGAP5: view

Protein tissue co-expression partners for ARHGAP5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGAP5 Gene

Orthologs for ARHGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP5 35
  • 93.75 (n)
  • 97.22 (a)
ARHGAP5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP5 35
  • 95.25 (n)
  • 98.4 (a)
ARHGAP5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap5 35
  • 93.54 (n)
  • 97.4 (a)
Arhgap5 16
Arhgap5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP5 35
  • 99.8 (n)
  • 100 (a)
ARHGAP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap5 35
  • 93.21 (n)
  • 97.55 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP5 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP5 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP5 35
  • 83.98 (n)
  • 91.41 (a)
ARHGAP5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP5 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap5 35
  • 74.97 (n)
  • 78.97 (a)
Str.9761 35
zebrafish
(Danio rerio)
Actinopterygii arhgap5 35
  • 68.31 (n)
  • 74.08 (a)
arhgap5 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 37
  • 33 (a)
RhoGAPp190 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for ARHGAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP5 Gene

ENSEMBL:
Gene Tree for ARHGAP5 (if available)
TreeFam:
Gene Tree for ARHGAP5 (if available)

Paralogs for ARHGAP5 Gene

Pseudogenes.org Pseudogenes for ARHGAP5 Gene

genes like me logo Genes that share paralogs with ARHGAP5: view

Variants for ARHGAP5 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17386818 - 32,090,718(+) TCAGT(A/G)TAGTT reference, missense
rs7140954 -- 32,085,587(+) CTTGC(A/G)AAAAG intron-variant
rs7141680 -- 32,120,133(+) tatag(G/T)gctat intron-variant
rs7492488 -- 32,150,251(+) tgact(C/T)aaatg intron-variant
rs8018027 -- 32,111,827(+) GTCAC(A/G)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP5 Gene

Variant ID Type Subtype PubMed ID
nsv832764 CNV Gain 17160897

Variation tolerance for ARHGAP5 Gene

Residual Variation Intolerance Score: 4.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP5 Gene

Human Gene Mutation Database (HGMD)
ARHGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Disorders for ARHGAP5 Gene

Relevant External Links for ARHGAP5

Genetic Association Database (GAD)
ARHGAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP5

No disorders were found for ARHGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP5 Gene

Publications for ARHGAP5 Gene

  1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PMID: 8537347) Burbelo P.D. … Yamada Y. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PMID: 10939588) Chakravarty G. … Rosen J.M. (Cell Growth Differ. 2000) 3 23
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. (PMID: 25961434) Fang Y. … Song W. (Oncotarget 2015) 3
  5. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. (PMID: 23474761) Wang J. … Jiang F. (Oncogene 2014) 3

Products for ARHGAP5 Gene

Sources for ARHGAP5 Gene

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