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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP5 Gene

protein-coding   GIFtS: 63
GCID: GC14P032546

Rho GTPase Activating Protein 5

(Previous name: growth factor independent 2)
(Previous symbol: GFI2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 51 2     RhoGAP52
GFI21 2     P100 RasGAP-Associated P105 Protein2
Growth Factor Independent 21 2     P105 RhoGAP2
Rho-Type GTPase-Activating Protein 52 3     p190BRhoGAP2
p190-B2 3     Rho GTPase-Activating Protein 52
RHOGAP53 5     

External Ids:    HGNC: 6751   Entrez Gene: 3942   Ensembl: ENSG000001008527   OMIM: 6026805   UniProtKB: Q130173   

Export aliases for ARHGAP5 gene to outside databases

Previous GC identifers: GC14P030000 GC14P026333 GC14P030536 GC14P031615 GC14P012663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP5 Gene:
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes
by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGAP5 Gene: 
ARHGAP5 (Rho GTPase activating protein 5) is a protein-coding gene. Diseases associated with ARHGAP5 include pituitary adenoma, and adenoma, and among its related super-pathways are Focal Adhesion and Signaling by Rho GTPases. GO annotations related to this gene include SH2 domain binding and GTP binding. An important paralog of this gene is ARHGAP17.

UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
Function: GTPase-activating protein for Rho family members. May play a role in the reduction of the
p21rasGTPase-activating potential of RASA1/p120GAP

Gene Wiki entry for ARHGAP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP5 gene promoter:
         CREB   LHX3b/Lhx3b   STAT1   Nkx2-2   deltaCREB   Pax-4a   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P032546:  view genomic region     (about GC identifiers)

Start:
32,545,320 bp from pter      End:
32,628,934 bp from pter
Size:
83,615 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 5  
Size: 1502 amino acids; 172460 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found
in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin
Sequence caution: Sequence=AAA95963.1; Type=Frameshift; Positions=Several; Sequence=AAH32723.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from and Proteopedia for ARHGAP5:
2EE4 (3D)        2EE5 (3D)    
Secondary accessions: A1L375 A1L376 A8KAA1 D3DS89 D3DS90 Q05BE8 Q05BU8 Q59ER0 Q6DHZ3
Alternative splicing: 4 isoforms:  Q13017-1   Q13017-2   Q13017-3   Q13017-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP5: NX_Q13017

Explore proteomics data for ARHGAP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13017

  • ARHGAP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001025226.1  NP_001164.2  

    ENSEMBL proteins: 
     ENSP00000452372   ENSP00000452222   ENSP00000441692   ENSP00000379827   ENSP00000407395  
     ENSP00000451579   ENSP00000451061   ENSP00000452606   ENSP00000371897   ENSP00000393307  
    Reactome Protein details: Q13017
    Human Recombinant Protein Products for ARHGAP5: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS8537347
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    ARHGAP5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR002713 FF_domain
     IPR027417 P-loop_NTPase
     IPR008936 Rho_GTPase_activation_prot
     IPR001806 Small_GTPase
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q13017

    ProtoNet protein and cluster: Q13017

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB002713 FF domain


    UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
    Similarity: Contains 4 FF domains
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG05_HUMAN, Q13017
    Function: GTPase-activating protein for Rho family members. May play a role in the reduction of the
    p21rasGTPase-activating potential of RASA1/p120GAP

         Genatlas biochemistry entry for ARHGAP5:
    Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8537347
    GO:0005100Rho GTPase activator activity TAS8537347
    GO:0005525GTP binding IEA--
    GO:0042169SH2 domain binding IPI1689011
         
    ARHGAP5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP5:
     Decreased focal adhesion (FA)   Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap5):
     adipose tissue  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     integument  mortality/aging  nervous system  respiratory system 

    ARHGAP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgap5tm1Jset for ARHGAP5

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP5 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    3GPCR Pathway
    Ras Pathway0.73
    4Signaling by GPCR
    Signal Transduction0.55
    5G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ARHGAP5
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling Cross-talk between Ras-family GTPases

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGAP5
        RhoA Pathway
    G12-G13 in Cellular Signaling
    RhoGDI Pathway
    Transendothelial Migration of Leukocytes
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for ARHGAP5
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for ARHGAP5
        G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Regulation of CDC42 activity

    3 BioSystems Pathways for ARHGAP5
        Focal Adhesion
    Regulation of RhoA activity
    RAC1 signaling pathway

    3        Reactome Pathways for ARHGAP5
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    2         Kegg Pathways  (Kegg details for ARHGAP5):
        Focal adhesion
    Leukocyte transendothelial migration


    ARHGAP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for ARHGAP5 (Q130172, 3 ENSP000003718974) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61793 I2D: score=4 
    RASA1P209363, ENSP000002743764I2D: score=3 STRING: ENSP00000274376
    PTK2BQ142893, ENSP000003328164I2D: score=2 STRING: ENSP00000332816
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0006184GTP catabolic process TAS8537347
    GO:0007155cell adhesion TAS8537347
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    ARHGAP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP5 (RHG05)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP5 / RHG05

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP5 gene (2 alternative transcripts): 
    NM_001030055.1  NM_001173.2  

    Unigene Cluster for ARHGAP5:

    Rho GTPase activating protein 5
    Hs.592313  [show with all ESTs]
    Unigene Representative Sequence: NM_001030055
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555814 ENST00000556611 ENST00000539826 ENST00000396582 ENST00000433497
    ENST00000556191 ENST00000554090 ENST00000557643 ENST00000216743 ENST00000345122(uc001wrl.3 uc001wrn.3)
    ENST00000432921(uc001wrm.3 uc001wro.3 uc001wrp.3)
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    Additional mRNA sequence: 

    AB209751.1 AK023014.1 AK023468.1 AK292966.1 AK307454.1 AY316523.1 BC032723.2 BC050059.1 
    BC075799.1 BC129928.1 BC129929.1 U17032.1 

    11 DOTS entries:

    DT.443531  DT.95138928  DT.97799782  DT.91915557  DT.101971713  DT.40120106  DT.100725656  DT.120787789 
    DT.92434681  DT.95330255  DT.91743594 

    24/136 AceView cDNA sequences (see all 136):

    AW510501 R30764 BX486747 AU141217 BM127896 CB068360 AA329829 CB133879 
    BM712978 AI587378 AW295718 BC075799 AI650272 AL045112 AI570955 CR596496 
    BF438091 BE301781 CK430128 BC050059 BC032723 BQ001780 CB134399 BU153875 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                                                                                                
    SP2:                                                  -     -                                       
    SP3:              -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                
    SP5:        -     -                                                                                 


    ECgene alternative splicing isoforms for ARHGAP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP5 expression in normal human tissues (normalized intensities)      ARHGAP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCAAAG
    ARHGAP5 Expression
    About this image


    ARHGAP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
             mouse/organ system/cardiovascular system   

    See ARHGAP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP5

    SOURCE GeneReport for Unigene cluster: Hs.592313

    UniProtKB/Swiss-Prot: RHG05_HUMAN, Q13017
    Tissue specificity: Expressed in kidney, brain, liver and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARHGAP5: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP5 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap51 , 5 Rho GTPase activating protein 51, 5 93.54(n)1
    97.4(a)1
      12 (22.16 cM)5
    118551  NM_009706.21  NP_033836.21 
     525160775 
    chicken
    (Gallus gallus)
    Aves ARHGAP51 Rho GTPase activating protein 5 83.98(n)
    91.41(a)
      428883  XM_426439.3  XP_426439.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP56
    Rho GTPase activating protein 5
    91(a)
    1 ↔ 1
    2(56415036-56451227)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851201.12   -- 72.92(n)    BX851201.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap51 Rho GTPase activating protein 5 68.52(n)
    74.36(a)
      795752  XM_001335980.1  XP_001336016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1903 mushroom body development Rho GTPase
    activator
    33(a)   16B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea rga-51 Protein RGA-5 44.06(n)
    30.7(a)
      178348  NM_001028086.2  NP_001023257.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BEM36
    Rho GTPase activating protein (RhoGAP) involved in...
    10(a)
    1 → many
    XVI(332100-335486)


    ENSEMBL Gene Tree for ARHGAP5 (if available)
    TreeFam Gene Tree for ARHGAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP5 gene
    ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP82  ARHGAP442  
    ARHGAP12  PRR5-ARHGAP82  SH3BP12  ARHGAP252  SRGAP22  ARHGAP42  
    18/20 SIMAP similar genes for ARHGAP5 using alignment to 6 protein entries:     RHG05_HUMAN (see all proteins) (see all similar genes):
    GRLF1    ARHGAP35    ARHGAP27    FAM13B    CHN1    CHN2
    ARHGAP33    MYO9A    ABR    ARHGAP21    ARHGAP4    MYO9B
    ARHGAP1    SH3BP1    ARHGAP12    ARHGAP44    ARHGAP24    ARHGAP42

    ARHGAP5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARHGAP5
    PGOHUM00000235374 PGOHUM00000233237


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1521 SNPs in ARHGAP5 are shown (see all 1521)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783375531,2
    Cuntested132561340(+) AAGAAG/AAGTTT 4 /K /E mis11Minor allele frequency- A:0.00EU 795
    rs1836291361,2
    --32548014(+) GGTTTA/GAAAAT 2 -- int10--------
    rs1902733781,2
    --32548103(+) TGTAGA/GTAAGT 2 -- int10--------
    rs1480501561,2
    --32548135(+) CTACTA/GGATAG 2 -- int10--------
    rs1932674481,2
    C--32548190(+) TTTTTC/GCTTTC 2 -- int10--------
    rs1181704821,2
    F--32548368(+) TATTGA/TTCTAA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs740415841,2
    C,F--32548601(+) AAACGG/ACCTTA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs794793811,2
    F--32548639(+) ATTACC/GTTAAT 2 -- int11Minor allele frequency- G:0.07NA 120
    rs1164967241,2
    C,F--32548947(+) TAAATA/GTGAAA 2 -- int11Minor allele frequency- G:0.13WA 118
    rs1161221341,2
    F--32549057(+) GTCCAC/TAGTTT 2 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ARHGAP5 (32545320 - 32628934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARHGAP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832764CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602680    OMIM disorders: --

    5 diseases for ARHGAP5:    About MalaCards
    pituitary adenoma    adenoma    hepatocellular carcinoma    endotheliitis
    breast cancer


    ARHGAP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP5

    Export disorders for ARHGAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP5 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with ARHGAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PubMed id 8537347)1, 2, 3, 9 Burbelo P.D....Yamada Y. (1995)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2 Zhan X. and Desiderio D.M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PubMed id 10939588)1, 9 Chakravarty G....Rosen J.M. (2000)
    5. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    6. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    7. Interaction of p190RhoGAP with C-terminal domain of p1 20-catenin modulates endothelial cytoskeleton and permeability. (PubMed id 23653363)1 Zebda N....Birukov K.G. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 394 HGNC: 675 AceView: ARHGAP5 Ensembl:ENSG00000100852 euGenes: HUgn394
    ECgene: ARHGAP5 Kegg: 394 H-InvDB: ARHGAP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP5 gene:
    Search GeneIP for patents involving ARHGAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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