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Aliases for ARHGAP45 Gene

Aliases for ARHGAP45 Gene

  • Rho GTPase Activating Protein 45 2 3 5
  • Histocompatibility (Minor) HA-1 2 3
  • HMHA1 3 4
  • Minor Histocompatibility Antigen HA-1 3
  • Minor Histocompatibility Protein HA-1 3
  • KIAA0223 4
  • HLA-HA1 3
  • HA-1 3

External Ids for ARHGAP45 Gene

Previous HGNC Symbols for ARHGAP45 Gene

  • HMHA1

Summaries for ARHGAP45 Gene

GeneCards Summary for ARHGAP45 Gene

ARHGAP45 (Rho GTPase Activating Protein 45) is a Protein Coding gene. Among its related pathways are Innate Immune System and Signaling by GPCR. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot for ARHGAP45 Gene

  • GTPase activator for the Rho-type GTPases.

  • Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Gene Wiki entry for ARHGAP45 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP45 Gene

Genomics for ARHGAP45 Gene

Regulatory Elements for ARHGAP45 Gene

Enhancers for ARHGAP45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G000906 2 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -157.4 -157365 4.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 CFD MIDN ARHGAP45 R3HDM4 ABCA7 ELANE PRTN3 GZMM SBNO2 CIRBP
GH19G001065 1.6 FANTOM5 ENCODE dbSUPER 19 +1.2 1235 6.0 HDGF MLX AGO1 WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF143 ARHGAP45 ABCA7 LOC100288123 TMEM259 MIER2 POLR2E SBNO2 ENSG00000267317 POLRMT MIDN
GH19G001236 1.9 FANTOM5 ENCODE dbSUPER 12.9 +190.9 190936 41.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 SF3A2 TMEM259 C19orf24 LOC100288123 CIRBP MIER2 MIDN ENSG00000267317 MUM1 RPS15
GH19G001025 1.8 FANTOM5 ENCODE dbSUPER 12.2 -37.5 -37543 5.8 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 SP3 ABCA7 CNN2 C19orf24 ARHGAP45 SCAMP4 GRIN3B SBNO2 GZMM R3HDM4 RNU6-2
GH19G001074 1.6 Ensembl ENCODE dbSUPER 11.8 +10.5 10546 4.5 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT SIN3A ARID4B FEZF1 SLC30A9 POLR2E LOC100288123 TMEM259 ABCA7 ARHGAP45 ENSG00000267317 ADAT3 GRIN3B PIR52456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP45 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105610 1677 1201 HDGF AGO1 ARID4B GLIS2 ZNF143 SP5 MXD4 SMARCB1 NR2C1 KDM1A

Genomic Location for ARHGAP45 Gene

Chromosome:
19
Start:
1,065,923 bp from pter
End:
1,087,831 bp from pter
Size:
21,909 bases
Orientation:
Plus strand

Genomic View for ARHGAP45 Gene

Genes around ARHGAP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP45 Gene

Proteins for ARHGAP45 Gene

  • Protein details for ARHGAP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92619-HMHA1_HUMAN
    Recommended name:
    Minor histocompatibility protein HA-1
    Protein Accession:
    Q92619
    Secondary Accessions:
    • B4DTS4
    • F6QP70
    • Q6P189
    • Q7LE26
    • Q86WS1
    • Q8HX84
    • Q9GJN9
    • Q9GJP0
    • Q9GJP1
    • Q9MY24

    Protein attributes for ARHGAP45 Gene

    Size:
    1136 amino acids
    Molecular mass:
    124614 Da
    Quaternary structure:
    • HA-1 forms a complex with MHC class I HLA-A*0201.
    Miscellaneous:
    • Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag HA-1-positive patients with leukemia or multiple myeloma.
    SequenceCaution:
    • Sequence=BAA13212.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP45 Gene

    Alternative splice isoforms for ARHGAP45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP45 Gene

Post-translational modifications for ARHGAP45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP45 Gene

Domains & Families for ARHGAP45 Gene

Protein Domains for ARHGAP45 Gene

Suggested Antigen Peptide Sequences for ARHGAP45 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP45: view

No data available for UniProtKB/Swiss-Prot for ARHGAP45 Gene

Function for ARHGAP45 Gene

Molecular function for ARHGAP45 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases.
UniProtKB/Swiss-Prot Function:
Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Gene Ontology (GO) - Molecular Function for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 24086303
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARHGAP45: view
genes like me logo Genes that share phenotypes with ARHGAP45: view

Animal Model Products

miRNA for ARHGAP45 Gene

miRTarBase miRNAs that target ARHGAP45

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP45 Gene

Localization for ARHGAP45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP45 gene
Compartment Confidence
cytosol 5
extracellular 4
lysosome 4
plasma membrane 3
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP45 Gene

Pathways & Interactions for ARHGAP45 Gene

genes like me logo Genes that share pathways with ARHGAP45: view

Pathways by source for ARHGAP45 Gene

Gene Ontology (GO) - Biological Process for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP45: view

No data available for SIGNOR curated interactions for ARHGAP45 Gene

Drugs & Compounds for ARHGAP45 Gene

(4) Additional Compounds for ARHGAP45 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with ARHGAP45: view

Transcripts for ARHGAP45 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP45 Gene

No ASD Table

Relevant External Links for ARHGAP45 Gene

GeneLoc Exon Structure for
ARHGAP45
ECgene alternative splicing isoforms for
ARHGAP45

Expression for ARHGAP45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP45 Gene:

ARHGAP45

mRNA Expression by UniProt/SwissProt for ARHGAP45 Gene:

Q92619-HMHA1_HUMAN
Tissue specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue.

Evidence on tissue expression from TISSUES for ARHGAP45 Gene

  • Blood(4.5)
  • Liver(4.4)
  • Nervous system(4.4)
  • Bone marrow(4.3)
  • Muscle(2.5)
  • Kidney(2.2)
  • Intestine(2.1)
  • Heart(2)