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Aliases for ARHGAP45 Gene

Aliases for ARHGAP45 Gene

  • Rho GTPase Activating Protein 45 2 3 5
  • Histocompatibility (Minor) HA-1 2 3
  • HMHA1 3 4
  • Minor Histocompatibility Antigen HA-1 3
  • Minor Histocompatibility Protein HA-1 3
  • KIAA0223 4
  • HLA-HA1 3
  • HA-1 3

External Ids for ARHGAP45 Gene

Previous HGNC Symbols for ARHGAP45 Gene

  • HMHA1

Summaries for ARHGAP45 Gene

GeneCards Summary for ARHGAP45 Gene

ARHGAP45 (Rho GTPase Activating Protein 45) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot for ARHGAP45 Gene

  • GTPase activator for the Rho-type GTPases.

  • Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Gene Wiki entry for ARHGAP45 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP45 Gene

Genomics for ARHGAP45 Gene

Regulatory Elements for ARHGAP45 Gene

Enhancers for ARHGAP45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F000906 1.5 FANTOM5 ENCODE 29.5 -157.4 -157365 4.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ARHGAP45 CFD MIDN R3HDM4 CIRBP ABCA7 ENSG00000261526 ELANE PRTN3 GZMM
GH19F001065 1.4 FANTOM5 ENCODE 19 +1.2 1235 6.0 HDGF MLX WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF263 ARHGAP45 ABCA7 POLR2E SBNO2 MIDN R3HDM4 CIRBP TMEM259 PIR52456
GH19F000942 1.8 FANTOM5 Ensembl ENCODE 12.8 -112.6 -112581 21.8 HDGF PKNOX1 ARNT MLX CREB3L1 SIN3A ARID4B DMAP1 ZNF2 ZNF766 ARHGAP45 WDR18 ARID3A KISS1R SBNO2 ENSG00000267159 PALM RPS15 MIDN EFNA2
GH19F001083 1.4 FANTOM5 Ensembl ENCODE 15.9 +21.1 21085 6.1 ZNF76 ZNF48 GLIS2 EGR1 ZNF366 SCRT2 PAF1 CBFB GATAD2B TBX21 POLR2E ABCA7 ARHGAP45 MIDN GPX4 SBNO2 HCN2 R3HDM4 ARID3A CIRBP
GH19F001236 1.6 FANTOM5 ENCODE 12.9 +190.9 190936 41.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SF3A2 TMEM259 LOC100288123 C19orf24 MIER2 ENSG00000267317 MIDN CIRBP MUM1 RPS15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP45 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP45 Gene

Chromosome:
19
Start:
1,065,923 bp from pter
End:
1,087,831 bp from pter
Size:
21,909 bases
Orientation:
Plus strand

Genomic View for ARHGAP45 Gene

Genes around ARHGAP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP45 Gene

Proteins for ARHGAP45 Gene

  • Protein details for ARHGAP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92619-HMHA1_HUMAN
    Recommended name:
    Minor histocompatibility protein HA-1
    Protein Accession:
    Q92619
    Secondary Accessions:
    • B4DTS4
    • F6QP70
    • Q6P189
    • Q7LE26
    • Q86WS1
    • Q8HX84
    • Q9GJN9
    • Q9GJP0
    • Q9GJP1
    • Q9MY24

    Protein attributes for ARHGAP45 Gene

    Size:
    1136 amino acids
    Molecular mass:
    124614 Da
    Quaternary structure:
    • HA-1 forms a complex with MHC class I HLA-A*0201.
    Miscellaneous:
    • Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag HA-1-positive patients with leukemia or multiple myeloma.
    SequenceCaution:
    • Sequence=BAA13212.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP45 Gene

    Alternative splice isoforms for ARHGAP45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP45 Gene

Post-translational modifications for ARHGAP45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP45 Gene

Domains & Families for ARHGAP45 Gene

Protein Domains for ARHGAP45 Gene

Suggested Antigen Peptide Sequences for ARHGAP45 Gene

Graphical View of Domain Structure for InterPro Entry

Q92619

UniProtKB/Swiss-Prot:

HMHA1_HUMAN :
  • Contains 1 F-BAR domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 Rho-GAP domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with ARHGAP45: view

Function for ARHGAP45 Gene

Molecular function for ARHGAP45 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases.
UniProtKB/Swiss-Prot Function:
Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Gene Ontology (GO) - Molecular Function for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 24086303
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARHGAP45: view
genes like me logo Genes that share phenotypes with ARHGAP45: view

Animal Model Products

miRNA for ARHGAP45 Gene

miRTarBase miRNAs that target ARHGAP45

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP45 Gene

Localization for ARHGAP45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP45 gene
Compartment Confidence
cytosol 5
extracellular 4
lysosome 4
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ARHGAP45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP45 Gene

Pathways & Interactions for ARHGAP45 Gene

genes like me logo Genes that share pathways with ARHGAP45: view

Pathways by source for ARHGAP45 Gene

Gene Ontology (GO) - Biological Process for ARHGAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP45: view

No data available for SIGNOR curated interactions for ARHGAP45 Gene

Drugs & Compounds for ARHGAP45 Gene

(4) Additional Compounds for ARHGAP45 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with ARHGAP45: view

Transcripts for ARHGAP45 Gene

Unigene Clusters for ARHGAP45 Gene

Histocompatibility (minor) HA-1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP45 Gene

No ASD Table

Relevant External Links for ARHGAP45 Gene

GeneLoc Exon Structure for
ARHGAP45
ECgene alternative splicing isoforms for
ARHGAP45

Expression for ARHGAP45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP45 Gene:

ARHGAP45

SOURCE GeneReport for Unigene cluster for ARHGAP45 Gene:

Hs.465521

mRNA Expression by UniProt/SwissProt for ARHGAP45 Gene:

Q92619-HMHA1_HUMAN
Tissue specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue.
genes like me logo Genes that share expression patterns with ARHGAP45: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ARHGAP45 Gene

Orthologs for ARHGAP45 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMHA1 34 35
  • 93.3 (n)
dog
(Canis familiaris)
Mammalia HMHA1 34 35
  • 83.17 (n)
cow
(Bos Taurus)
Mammalia HMHA1 35 34
  • 82.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hmha1 16 35 34
  • 80.26 (n)
rat
(Rattus norvegicus)
Mammalia Hmha1 34
  • 79.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HMHA1 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMHA1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMHA1 34 35
  • 74.2 (n)
lizard
(Anolis carolinensis)
Reptilia HMHA1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmha1 34
  • 60.16 (n)
Str.11397 34
zebrafish
(Danio rerio)
Actinopterygii hmha1b 34
  • 65.02 (n)
hmha1 35
  • 52 (a)
OneToMany
HMHA1 (1 of 3) 35
  • 52 (a)
OneToMany
HMHA1 (3 of 3) 35
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11163 34
worm
(Caenorhabditis elegans)
Secernentea spv-1 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 35
  • 15 (a)
ManyToMany
RGA2 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for ARHGAP45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP45 Gene

ENSEMBL:
Gene Tree for ARHGAP45 (if available)
TreeFam:
Gene Tree for ARHGAP45 (if available)

Paralogs for ARHGAP45 Gene

Paralogs for ARHGAP45 Gene

genes like me logo Genes that share paralogs with ARHGAP45: view

Variants for ARHGAP45 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP45 Gene

HMHA1_HUMAN-Q92619
The HA-1H allele is presented on the cell surface and recognized by CTL, whereas the HA-1R allele is poorly represented by HLA-A and non-immunogenic, although HA-1R allelic frequency is the highest (PubMed:9820595, PubMed:16399573).

Sequence variations from dbSNP and Humsavar for ARHGAP45 Gene