Aliases for ARHGAP45 Gene
Aliases for ARHGAP45 Gene
External Ids for ARHGAP45 Gene
- HGNC: 17102
- Entrez Gene: 23526
- Ensembl: ENSG00000180448
- OMIM: 601155
- UniProtKB: Q92619
Previous HGNC Symbols for ARHGAP45 Gene
- HMHA1
Summaries for ARHGAP45 Gene
GeneCards Summary for ARHGAP45 Gene
ARHGAP45 (Rho GTPase Activating Protein 45) is a Protein Coding gene. Among its related pathways are Innate Immune System and Signaling by GPCR. An important paralog of this gene is ARHGAP29.
UniProtKB/Swiss-Prot for ARHGAP45 Gene
-
GTPase activator for the Rho-type GTPases.
-
Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP45 Gene
Genomics for ARHGAP45 Gene
Regulatory Elements for ARHGAP45 Gene
Enhancers for ARHGAP45 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ARHGAP45 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ARHGAP45 Gene
- Chromosome:
- 19
- Start:
- 1,065,923 bp from pter
- End:
- 1,087,831 bp from pter
- Size:
- 21,909 bases
- Orientation:
- Plus strand
Genomic View for ARHGAP45 Gene
Genes around ARHGAP45 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
ARHGAP45 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP45 Gene
Proteins for ARHGAP45 Gene
-
Protein details for ARHGAP45 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92619-HMHA1_HUMAN
- Recommended name:
- Minor histocompatibility protein HA-1
- Protein Accession:
- Q92619
- B4DTS4
- F6QP70
- Q6P189
- Q7LE26
- Q86WS1
- Q8HX84
- Q9GJN9
- Q9GJP0
- Q9GJP1
- Q9MY24
Protein attributes for ARHGAP45 Gene
- Size:
- 1136 amino acids
- Molecular mass:
- 124614 Da
- Quaternary structure:
-
- HA-1 forms a complex with MHC class I HLA-A*0201.
- Miscellaneous:
-
- Infusion of lymphocyte from mHag HA-1-negative donors results in a durable remission in mHag HA-1-positive patients with leukemia or multiple myeloma.
- SequenceCaution:
-
- Sequence=BAA13212.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for ARHGAP45 Gene
Other Protein References for ARHGAP45 Gene
Antibody Products
-
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-
Abcam antibodies for ARHGAP45
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- antibodies-online Antibodies for ARHGAP45: See all 36
- GeneTex HMHA1 antibody for ARHGAP45
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Cloud-Clone Corp. Proteins for ARHGAP45
- antibodies-online Proteins for ARHGAP45: See all 3
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-
Abcam proteins for ARHGAP45
Assay Products
No data available for DME Specific Peptides for ARHGAP45 Gene
Domains & Families for ARHGAP45 Gene
Gene Families for ARHGAP45 Gene
Protein Domains for ARHGAP45 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGAP45 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ARHGAP45 Gene
Function for ARHGAP45 Gene
Molecular function for ARHGAP45 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the Rho-type GTPases.
- UniProtKB/Swiss-Prot Function:
- Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 24086303 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ARHGAP45 Gene
- GenomeRNAi human phenotypes for ARHGAP45:
Animal Model Products
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miRNA for ARHGAP45 Gene
- miRTarBase miRNAs that target ARHGAP45
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ARHGAP45
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP45 Gene
Localization for ARHGAP45 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| lysosome | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0032587 | ruffle membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP45 Gene
Pathways & Interactions for ARHGAP45 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | p75 NTR receptor-mediated signalling |
.36
|
|
| 3 | Signaling by GPCR | ||
| 4 | Signaling by Rho GTPases | ||
Pathways by source for ARHGAP45 Gene
6 Reactome pathways for ARHGAP45 Gene
Interacting Proteins for ARHGAP45 Gene
Selected Interacting proteins:
ENSP00000316772
Q92619-HMHA1_HUMAN
for ARHGAP45 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS | -- |
No data available for SIGNOR curated interactions for ARHGAP45 Gene
Drugs & Compounds for ARHGAP45 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Diglycerides Group A |
|
|
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| Diglycerides Group B |
|
|
||||
| Diglycerides Group C |
|
|
|
|||
| Diglycerides Group D |
|
|
Transcripts for ARHGAP45 Gene
mRNA/cDNA for ARHGAP45 Gene
- (8) REFSEQ mRNAs :
- (193) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ARHGAP45
- GenScript: Design CRISPR guide RNA sequences for ARHGAP45
miRNA Products
- Search ViGene Biosciences for ARHGAP45
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ARHGAP45
- Browse OriGene Inhibitory RNA Products For ARHGAP45
-
ViGene Biosciences ready-to-package AAV shRNAs for ARHGAP45 gene
Clone Products
- Sino Biological Human cDNA Clone for ARHGAP45
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARHGAP45
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARHGAP45
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ARHGAP45 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
NURSA nuclear receptor signaling pathways regulating expression of ARHGAP45 Gene:
ARHGAP45mRNA Expression by UniProt/SwissProt for ARHGAP45 Gene:
Q92619-HMHA1_HUMAN
Tissue specificity:
Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue.
Evidence on tissue expression from TISSUES for ARHGAP45 Gene
- Blood(4.5)
- Liver(4.4)
- Nervous system(4.4)
- Bone marrow(4.3)
- Muscle(2.5)
- Kidney(2.2)
- Intestine(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for ARHGAP45
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP45 Gene
Orthologs for ARHGAP45 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMHA1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HMHA1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HMHA1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmha1 34 35 |
|
||
| Arhgap45 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Hmha1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMHA1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HMHA1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMHA1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMHA1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmha1 34 |
|
||
| Str.11397 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hmha1b 34 |
|
||
| hmha1 35 |
|
OneToMany | |||
| HMHA1 (1 of 3) 35 |
|
OneToMany | |||
| HMHA1 (3 of 3) 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11163 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | spv-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RGA1 35 |
|
ManyToMany | |
| RGA2 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ARHGAP45 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARHGAP45 Gene
Variants for ARHGAP45 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP45 Gene
- HMHA1_HUMAN-Q92619
- The HA-1H allele is presented on the cell surface and recognized by CTL, whereas the HA-1R allele is poorly represented by HLA-A and non-immunogenic, although HA-1R allelic frequency is the highest (PubMed:9820595, PubMed:16399573).
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018092 | -- | 1,086,523(+) | ACCAG(A/G)TGTGG | downstream-variant-500B, utr-variant-3-prime | |
| rs1000043948 | -- | 1,065,936(+) | AGGAG(C/T)CCGGT | downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000063154 | -- | 1,083,786(+) | CCCAG(A/G)CTGAA | intron-variant | |
| rs1000160944 | -- | 1,076,274(+) | TTAAC(A/C)TTTGC | intron-variant, upstream-variant-2KB | |
| rs1000212991 | -- | 1,076,127(+) | CATTG(A/C)TATGA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv135n111 | CNV | deletion | 26073780 |
| dgv136n111 | CNV | deletion | 26073780 |
| esv2758743 | CNV | gain+loss | 17122850 |
| esv3643383 | CNV | gain | 21293372 |
| nsv1058677 | CNV | loss | 25217958 |
| nsv1160555 | CNV | deletion | 26073780 |
| nsv469845 | CNV | loss | 16826518 |
| nsv470102 | CNV | loss | 18288195 |
| nsv470103 | CNV | gain | 18288195 |
| nsv828362 | CNV | loss | 20364138 |
| nsv833704 | CNV | gain | 17160897 |
| nsv953938 | CNV | deletion | 24416366 |
| nsv9662 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
6.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.60;
82.63% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ARHGAP45 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARHGAP45
Disorders for ARHGAP45 Gene
Relevant External Links for ARHGAP45
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ARHGAP45
No disorders were found for ARHGAP45 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP45 Gene
Publications for ARHGAP45 Gene
- Expression of minor histocompatibility antigen, HA-1, in solid tumor cells. (PMID: 11965046) Fujii N. … Harada M. (Transplantation 2002) 3 4 22 64
- Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA). (PMID: 10958358) Arostegui J.I. … Granena A. (Tissue Antigens 2000) 3 4 22 64
- Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. (PMID: 11095984) Kaminski W.E. … Schmitz G. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
- Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR. (PMID: 9820596) Wilke M. … Goulmy E. (Tissue Antigens 1998) 2 3 22 64
- The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. (PMID: 9461441) den Haan J.M. … Goulmy E. (Science 1998) 3 4 22 64
Products for ARHGAP45 Gene
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- VectorBuilder custom plasmid, inducible vectors for ARHGAP45
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARHGAP45
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ARHGAP45 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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