Aliases for ARHGAP42 Gene
External Ids for ARHGAP42 Gene
Previous HGNC Symbols for ARHGAP42 Gene
Previous GeneCards Identifiers for ARHGAP42 Gene
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
GeneCards Summary for ARHGAP42 Gene
ARHGAP42 (Rho GTPase Activating Protein 42) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP10.
UniProtKB/Swiss-Prot for ARHGAP42 Gene
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.