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Aliases for ARHGAP42 Gene

Aliases for ARHGAP42 Gene

  • Rho GTPase Activating Protein 42 2 3 5
  • Rho-Type GTPase-Activating Protein 42 3 4
  • GRAF3 3 4
  • Rho GTPase-Activating Protein 10-Like 4
  • Rho GTPase-Activating Protein 42 3

External Ids for ARHGAP42 Gene

Previous GeneCards Identifiers for ARHGAP42 Gene

  • GC11P100559
  • GC11P096494

Summaries for ARHGAP42 Gene

GeneCards Summary for ARHGAP42 Gene

ARHGAP42 (Rho GTPase Activating Protein 42) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Cytoskeletal Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP26.

UniProtKB/Swiss-Prot for ARHGAP42 Gene

  • May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP42 Gene

Genomics for ARHGAP42 Gene

Regulatory Elements for ARHGAP42 Gene

Enhancers for ARHGAP42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G100774 1.3 Ensembl ENCODE dbSUPER 22.8 +88.9 88881 4.7 HNRNPUL1 KLF1 FOXA2 SIN3A DMAP1 ZNF384 ZNF644 FOSL1 GATA3 ZNF366 ARHGAP42 LOC100128386 TMEM133 RN7SKP115
GH11G100752 0.9 Ensembl ENCODE 30 +65.5 65546 2.0 CTCF NFIB TEAD4 ZIC2 OSR2 SCRT2 ZNF341 PRDM10 ARHGAP42 LOC100128386 RN7SKP115
GH11G100718 1.1 Ensembl ENCODE 11.1 +32.1 32080 1.6 FEZF1 RAD21 RFX5 YY1 GATA2 RCOR1 FOS NR2F2 MAFF SMARCA4 TMEM133 ARHGAP42 LOC100128386 RN7SKP115
GH11G100738 1 Ensembl ENCODE 11.2 +52.8 52774 4.0 SRF MTA2 RAD21 TBX21 NR2F2 POLR2A SMARCA4 IKZF1 BCL6B HNF4A TMEM133 ARHGAP42 LOC100128386 RN7SKP115
GH11G100632 1 Ensembl ENCODE 10.9 -54.5 -54464 2.3 NFIA NFIB MAX RAD21 FOXA1 NR2F2 GABPA YY1 TEAD3 NFIC ARHGAP42 LOC100128386 TMEM133 GC11M100607 RN7SL222P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP42 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043844 247 2601 TBP PKNOX1 ARID4B SIN3A DMAP1 ZBTB40 ZNF48 RAD21 RARA ETS1

Genomic Location for ARHGAP42 Gene

Chromosome:
11
Start:
100,687,653 bp from pter
End:
100,991,937 bp from pter
Size:
304,285 bases
Orientation:
Plus strand

Genomic View for ARHGAP42 Gene

Genes around ARHGAP42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP42 Gene

Proteins for ARHGAP42 Gene

  • Protein details for ARHGAP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI28-RHG42_HUMAN
    Recommended name:
    Rho GTPase-activating protein 42
    Protein Accession:
    A6NI28
    Secondary Accessions:
    • Q96M56

    Protein attributes for ARHGAP42 Gene

    Size:
    874 amino acids
    Molecular mass:
    98569 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BF511460; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for ARHGAP42 Gene

Post-translational modifications for ARHGAP42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP42 Gene

Domains & Families for ARHGAP42 Gene

Gene Families for ARHGAP42 Gene

Suggested Antigen Peptide Sequences for ARHGAP42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP42: view

No data available for UniProtKB/Swiss-Prot for ARHGAP42 Gene

Function for ARHGAP42 Gene

Molecular function for ARHGAP42 Gene

UniProtKB/Swiss-Prot Function:
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

Gene Ontology (GO) - Molecular Function for ARHGAP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,IDA 24335996
genes like me logo Genes that share ontologies with ARHGAP42: view

Phenotypes for ARHGAP42 Gene

genes like me logo Genes that share phenotypes with ARHGAP42: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP42 Gene

Localization for ARHGAP42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP42 gene
Compartment Confidence
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for ARHGAP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with ARHGAP42: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP42 Gene

Pathways & Interactions for ARHGAP42 Gene

genes like me logo Genes that share pathways with ARHGAP42: view

Pathways by source for ARHGAP42 Gene

1 Cell Signaling Technology pathway for ARHGAP42 Gene
3 Reactome pathways for ARHGAP42 Gene

Interacting Proteins for ARHGAP42 Gene

Gene Ontology (GO) - Biological Process for ARHGAP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0007165 signal transduction IEA --
GO:0035024 negative regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0090630 activation of GTPase activity IDA 24335996
genes like me logo Genes that share ontologies with ARHGAP42: view

No data available for SIGNOR curated interactions for ARHGAP42 Gene

Drugs & Compounds for ARHGAP42 Gene

No Compound Related Data Available

Transcripts for ARHGAP42 Gene

mRNA/cDNA for ARHGAP42 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP42 Gene

Rho GTPase activating protein 42:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP42 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -

Relevant External Links for ARHGAP42 Gene

GeneLoc Exon Structure for
ARHGAP42
ECgene alternative splicing isoforms for
ARHGAP42

Expression for ARHGAP42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP42 Gene

This gene is overexpressed in Placenta (51.4), Peripheral blood mononuclear cells (8.3), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGAP42 Gene



Protein tissue co-expression partners for ARHGAP42 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP42 Gene:

ARHGAP42

SOURCE GeneReport for Unigene cluster for ARHGAP42 Gene:

Hs.741465

mRNA Expression by UniProt/SwissProt for ARHGAP42 Gene:

A6NI28-RHG42_HUMAN
Tissue specificity: Highly and selectively expressed in smooth muscle cells.
genes like me logo Genes that share expression patterns with ARHGAP42: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP42 Gene

Orthologs for ARHGAP42 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP42 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia FLJ32810 35
  • 97 (a)
OneToOne
ARHGAP42 34
  • 90.35 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP42 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP42 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP42 34 35
  • 92.43 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap42 34
  • 88.33 (n)
mouse
(Mus musculus)
Mammalia Arhgap42 34 16 35
  • 87.82 (n)
chicken
(Gallus gallus)
Aves ARHGAP42 34 35
  • 81.88 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP42 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap42 34
  • 76.5 (n)
zebrafish
(Danio rerio)
Actinopterygii ARHGAP42 35
  • 72 (a)
OneToOne
arhgap42 34
  • 67.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Graf 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04C9.1 35
  • 36 (a)
OneToMany
Species where no ortholog for ARHGAP42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP42 Gene

ENSEMBL:
Gene Tree for ARHGAP42 (if available)
TreeFam:
Gene Tree for ARHGAP42 (if available)

Paralogs for ARHGAP42 Gene

genes like me logo Genes that share paralogs with ARHGAP42: view

Variants for ARHGAP42 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP42 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000004019 -- 100,940,210(+) TAAAG(-/A)AAAAA intron-variant
rs1000006502 -- 100,982,954(+) TTTGT(A/G)ATGTT intron-variant
rs1000029188 -- 100,921,965(+) GGAAG(C/T)TGTTG intron-variant
rs1000039623 -- 100,899,160(+) AGTGA(A/G)TTTCT intron-variant
rs1000039914 -- 100,844,843(+) GTGGG(A/G)ATGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP42 Gene

Variant ID Type Subtype PubMed ID
dgv1265n100 CNV gain 25217958
dgv1266n100 CNV gain 25217958
dgv1267n100 CNV gain 25217958
dgv228e214 CNV loss 21293372
esv1333643 CNV insertion 17803354
esv2529193 CNV insertion 19546169
esv2659208 CNV deletion 23128226
esv2667203 CNV deletion 23128226
esv2678215 CNV deletion 23128226
esv3304187 CNV mobile element insertion 20981092
esv3344349 CNV insertion 20981092
esv3355364 CNV insertion 20981092
esv3379245 CNV insertion 20981092
esv3440404 CNV insertion 20981092
esv3548242 CNV deletion 23714750
esv3627491 CNV loss 21293372
esv3627492 CNV loss 21293372
esv3627493 CNV loss 21293372
esv3627495 CNV loss 21293372
esv3627496 CNV loss 21293372
esv3627497 CNV loss 21293372
esv3627502 CNV gain 21293372
esv3627504 CNV loss 21293372
esv990975 CNV insertion 20482838
nsv1116682 CNV tandem duplication 24896259
nsv38828 CNV insertion 16902084
nsv460 CNV insertion 18451855
nsv468849 CNV loss 19166990
nsv478185 CNV novel sequence insertion 20440878
nsv520995 CNV gain 19592680
nsv556122 CNV gain 21841781
nsv556129 CNV loss 21841781
nsv826057 CNV loss 20364138
nsv832246 CNV gain 17160897
nsv951063 CNV duplication 24416366

Variation tolerance for ARHGAP42 Gene

Gene Damage Index Score: 8.52; 85.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP42 Gene

Human Gene Mutation Database (HGMD)
ARHGAP42
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP42 Gene

Disorders for ARHGAP42 Gene

Relevant External Links for ARHGAP42

Genetic Association Database (GAD)
ARHGAP42
Human Genome Epidemiology (HuGE) Navigator
ARHGAP42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP42

No disorders were found for ARHGAP42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP42 Gene

Publications for ARHGAP42 Gene

  1. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. (PMID: 24335996) Bai X. … Taylor J.M. (Nat Commun 2013) 3 4 64
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) . … Johnson T. (Nature 2011) 3 46 64
  4. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. (PMID: 18954304) Eberth A. … Ahmadian M.R. (Biochem. J. 2009) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ARHGAP42 Gene

Sources for ARHGAP42 Gene

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