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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP42 Gene

protein-coding   GIFtS: 38
GCID: GC11P100559

Rho GTPase activating protein 42

  Search for ARHGAP42
in our new
 Human Malady Compendium 
Biological research products
for ARHGAP42
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 421 2
GRAF31 2
Rho-Type GTPase-Activating Protein 422 3
FLJ328101
Rho GTPase-Activating Protein 422
Rho GTPase-Activating Protein 10-Like3

External Ids:    HGNC: 265451   Entrez Gene: 1438722   Ensembl: ENSG000001658957   UniProtKB: A6NI283   

Export aliases for ARHGAP42 gene to outside databases

Previous GC identifer: GC11P096494


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28
Function: May act as a GTPase activator (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGAP42
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARHGAP42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.1   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q22.1

ARHGAP42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP42 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P100559:  view genomic region     (about GC identifiers)

Start:
100,558,384 bp from pter      End:
100,861,656 bp from pter
Size:
303,273 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 42  
Size: 874 amino acids; 98569 Da
Sequence caution: Sequence=BAB71456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=BF511460; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the
C-terminal part;
Secondary accessions: Q96M56

Explore the universe of human proteins at neXtProt for ARHGAP42: NX_A6NI28

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NI28

  • ARHGAP42 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689645.2  
    ENSEMBL proteins: 
     ENSP00000431776   ENSP00000434304   ENSP00000435961   ENSP00000298815  

    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    ARHGAP42 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARHGAP42 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry A6NI28

    ProtoNet protein and cluster: A6NI28

    UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28
    Function: May act as a GTPase activator (By similarity)

    miRNA
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    hsa-miR-323-3p hsa-miR-15a hsa-miR-29b-1* hsa-miR-4314 hsa-miR-424 hsa-miR-3908 hsa-miR-532-5p hsa-miR-186
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008093cytoskeletal adaptor activity IEA--
    GO:0017124SH3 domain binding IEA--


    ARHGAP42 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ARHGAP42
        Cytoskeletal Signaling



    ARHGAP42 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP42

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0046847filopodium assembly IEA--


    ARHGAP42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP42
    Search CenterWatch for drugs/clinical trials and news about ARHGAP42 / RHG42 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP42 gene: 
    NM_152432.2  

    Unigene Cluster for ARHGAP42:

    Rho GTPase activating protein 42
    Hs.741465  [show with all ESTs]
    Unigene Representative Sequence: NM_152432
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524892 ENST00000534060 ENST00000529406 ENST00000524649 ENST00000525558
    ENST00000531183 ENST00000529535(uc001pgc.2) ENST00000298815(uc001pge.2 uc001pgd.2)


    miRNA
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    OriGene 3'-UTR Clone: ARHGAP42
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP42 (see all 44):
    hsa-miR-323-3p hsa-miR-15a hsa-miR-29b-1* hsa-miR-4314 hsa-miR-424 hsa-miR-3908 hsa-miR-532-5p hsa-miR-186
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: ARHGAP42
    OriGene siRNA: ARHGAP42
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    Clone
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    Additional cDNA sequence: 

    AF143327.1 AK023666.1 AK057372.1 

    10 DOTS entries:

    DT.455387  DT.95155708  DT.75151139  DT.101958866  DT.40108558  DT.100725604  DT.120736455  DT.305930 
    DT.75171666  DT.91705805 

    24/78 AceView cDNA sequences (see all 78):

    BQ187761 CK824101 BM564678 CB044016 CF552909 BF513771 CR620896 AA406599 
    BM726747 AA417982 AA278669 N30408 BX116126 AA282736 BM894179 AI417838 
    AW340014 BM014001 NM_032021 AL701071 BM804259 BU146672 AA348796 BF439533 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP42    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                          
    SP2:                                                                    -                     


    ECgene alternative splicing isoforms for ARHGAP42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTCTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARHGAP42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP42

    SOURCE GeneReport for Unigene cluster: Hs.741465
        SABiosciences Custom PCR Arrays for ARHGAP42
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP42 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARHGAP421 Rho GTPase activating protein 42 81.88(n)
    92.79(a)
      418990  XM_417185.3  XP_417185.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP426
    --
    89(a)
    1 ↔ 1
    3(193007784-193094047)
    zebrafish
    (Danio rerio)
    Actinopterygii BI845319.12   -- 70.19(n)    BI845319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Graf6
    Graf
    30(a)
    1 → many
    X(15645707-15654741)
    worm
    (Caenorhabditis elegans)
    Secernentea T04C9.16
    Protein T04C9.1, isoform c
    32(a)
    1 → many
    III(5993181-6006318)


    ENSEMBL Gene Tree for ARHGAP42 (if available)
    TreeFam Gene Tree for ARHGAP42 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP42 gene
    HMHA12  ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP232  ARHGAP92  ARHGAP292  
    CHN12  ARHGAP262  ARHGAP152  ARHGAP122  OPHN12  GMIP2  
    14 SIMAP similar genes for ARHGAP42 using alignment to 5 protein entries:     RHG42_HUMAN (see all proteins):
    GRAF    OPHN1    ARHGAP12    ARHGAP26    CHN2    ARHGAP31
    CHN1    ARHGAP5    ARHGAP21    ARHGAP10    ARHGAP24    ARHGAP23
    DKFZp667D142    ARHGAP9

    ARHGAP42 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARHGAP42
    PGOHUM00000247695 PGOHUM00000248032 PGOHUM00000246371 PGOHUM00000240311 PGOHUM00000240906


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5577 NCBI SNPs in ARHGAP42 are shown (see all 5577    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57940811,2
    C,F,--96757928(+) TTTTAT/-TTCTT 1 -- int1 tfbs33Minor allele frequency- -:0.33NA 6
    rs781514651,2
    C--100556451(+) AAAAAA/TAATTG 1 -- us2k10--------
    rs767150131,2
    C,--100556453(+) AAAAAA/TTTGAA 1 -- us2k10--------
    rs592377491,2
    C,F,--100556506(+) AATGGC/ATCTAA 1 -- us2k13Minor allele frequency- A:0.15WA 122
    rs1180262591,2
    C,F,--100556541(+) TGGGGC/TCAAAG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs750529601,2
    C,--100556634(+) CGGCT-/CATGGC 1 -- us2k10--------
    rs79288711,2
    C,F,A,--100556644(+) CAATCT/GCCGCC 1 -- us2k110Minor allele frequency- G:0.42NA WA CSA EA 370
    rs1501770901,2
    --100556647(+) TCGCCG/TCCTCC 1 -- us2k10--------
    rs1456197161,2
    --100556648(+) CGCCGC/TCTCCC 1 -- us2k10--------
    rs1488900331,2
    --100556670(+) ACTCTC/GCTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP42 (100558384 - 100808384 bp, first 250kb of ARHGAP42)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARHGAP42: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARHGAP42 for disorders           About MalaCards

    ARHGAP42 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ARHGAP42 (0 documents)

    Export disorders for ARHGAP42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP42 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARHGAP42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A BAR domain-mediated autoinhibitory mechanism for Rh oGAPs of the GRAF family. (PubMed id 18954304)1, 3 Eberth A....Ahmadian M.R. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
    4. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1  ....Johnson T. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143872 HGNC: 26545 AceView: AD031 Ensembl:ENSG00000165895 euGenes: HUgn143872
    ECgene: ARHGAP42 H-InvDB: ARHGAP42

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
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