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Aliases for ARHGAP42 Gene

Aliases for ARHGAP42 Gene

  • Rho GTPase Activating Protein 42 2 3 5
  • Rho-Type GTPase-Activating Protein 42 3 4
  • GRAF3 3 4
  • Rho GTPase-Activating Protein 10-Like 4

External Ids for ARHGAP42 Gene

Previous GeneCards Identifiers for ARHGAP42 Gene

  • GC11P100559
  • GC11P096494

Summaries for ARHGAP42 Gene

GeneCards Summary for ARHGAP42 Gene

ARHGAP42 (Rho GTPase Activating Protein 42) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP9.

UniProtKB/Swiss-Prot for ARHGAP42 Gene

  • May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP42 Gene

Genomics for ARHGAP42 Gene

Regulatory Elements for ARHGAP42 Gene

Enhancers for ARHGAP42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP42 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP42 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP42 Gene

100,687,653 bp from pter
100,991,937 bp from pter
304,285 bases
Plus strand

Genomic View for ARHGAP42 Gene

Genes around ARHGAP42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP42 Gene

Proteins for ARHGAP42 Gene

  • Protein details for ARHGAP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 42
    Protein Accession:
    Secondary Accessions:
    • Q96M56

    Protein attributes for ARHGAP42 Gene

    874 amino acids
    Molecular mass:
    98569 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BF511460; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for ARHGAP42 Gene

Proteomics data for ARHGAP42 Gene at MOPED

Post-translational modifications for ARHGAP42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP42 Gene

No data available for DME Specific Peptides for ARHGAP42 Gene

Domains & Families for ARHGAP42 Gene

Gene Families for ARHGAP42 Gene

Protein Domains for ARHGAP42 Gene

Suggested Antigen Peptide Sequences for ARHGAP42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAR domain.
  • Contains 1 BAR domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP42: view

Function for ARHGAP42 Gene

Molecular function for ARHGAP42 Gene

UniProtKB/Swiss-Prot Function:
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

Gene Ontology (GO) - Molecular Function for ARHGAP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP42: view

Phenotypes for ARHGAP42 Gene

genes like me logo Genes that share phenotypes with ARHGAP42: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP42 Gene

Localization for ARHGAP42 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP42 Gene COMPARTMENTS Subcellular localization image for ARHGAP42 gene
Compartment Confidence
cytosol 4
nucleus 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP42 Gene

Pathways & Interactions for ARHGAP42 Gene

SuperPathways for ARHGAP42 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with ARHGAP42: view

Pathways by source for ARHGAP42 Gene

1 Cell Signaling Technology pathway for ARHGAP42 Gene

Interacting Proteins for ARHGAP42 Gene

Gene Ontology (GO) - Biological Process for ARHGAP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGAP42: view

No data available for SIGNOR curated interactions for ARHGAP42 Gene

Drugs & Compounds for ARHGAP42 Gene

No Compound Related Data Available

Transcripts for ARHGAP42 Gene

Unigene Clusters for ARHGAP42 Gene

Rho GTPase activating protein 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP42 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP2: -

Relevant External Links for ARHGAP42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP42 Gene

mRNA expression in normal human tissues for ARHGAP42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP42 Gene

This gene is overexpressed in Placenta (51.4), Peripheral blood mononuclear cells (8.3), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGAP42 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP42 Gene Hs.741465

mRNA Expression by UniProt/SwissProt for ARHGAP42 Gene

Tissue specificity: Highly and selectively expressed in smooth muscle cells.
genes like me logo Genes that share expression patterns with ARHGAP42: view

Protein tissue co-expression partners for ARHGAP42 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGAP42 Gene

Orthologs for ARHGAP42 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP42 35
  • 90.35 (n)
  • 97.83 (a)
FLJ32810 36
  • 97 (a)
(Canis familiaris)
Mammalia ARHGAP42 35
  • 92.43 (n)
  • 96.72 (a)
  • 97 (a)
(Mus musculus)
Mammalia Arhgap42 35
  • 87.82 (n)
  • 96.19 (a)
Arhgap42 16
Arhgap42 36
  • 96 (a)
(Pan troglodytes)
Mammalia ARHGAP42 35
  • 99.32 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arhgap42 35
  • 88.33 (n)
  • 96.68 (a)
(Monodelphis domestica)
Mammalia ARHGAP42 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP42 36
  • 94 (a)
(Gallus gallus)
Aves ARHGAP42 35
  • 81.88 (n)
  • 92.79 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia ARHGAP42 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap42 35
  • 76.5 (n)
  • 85.99 (a)
(Danio rerio)
Actinopterygii arhgap42 35
  • 67.56 (n)
  • 74.04 (a)
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Graf 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T04C9.1 36
  • 36 (a)
Species with no ortholog for ARHGAP42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP42 Gene

Gene Tree for ARHGAP42 (if available)
Gene Tree for ARHGAP42 (if available)

Paralogs for ARHGAP42 Gene

genes like me logo Genes that share paralogs with ARHGAP42: view

Variants for ARHGAP42 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP42 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519235 -- 100,944,154(-) TCATG(A/G)TGATG intron-variant
rs519594 -- 100,954,485(-) GAAAG(C/T)CACTT intron-variant
rs520403 -- 100,939,612(-) AGTGC(A/G)GAAGG intron-variant
rs520539 -- 100,954,376(-) TTGTC(A/G)TTACA intron-variant
rs521216 -- 100,952,806(-) AGGTT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP42 Gene

Variant ID Type Subtype PubMed ID
nsv520995 CNV Gain 19592680
nsv832246 CNV Gain 17160897
nsv826057 CNV Loss 20364138
nsv898327 CNV Loss 21882294
nsv38828 CNV Insertion 16902084
nsv460 CNV Insertion 18451855
esv2667203 CNV Deletion 23128226
nsv468849 CNV Loss 19166990
esv2529193 CNV Insertion 19546169
esv273001 CNV Insertion 20981092
esv267405 CNV Insertion 20981092
esv990975 CNV Insertion 20482838
esv1333643 CNV Insertion 17803354
esv2678215 CNV Deletion 23128226
esv2659208 CNV Deletion 23128226
esv268466 CNV Insertion 20981092

Variation tolerance for ARHGAP42 Gene

Gene Damage Index Score: 8.52; 85.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP42 Gene

Disorders for ARHGAP42 Gene

Relevant External Links for ARHGAP42

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGAP42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP42 Gene

Publications for ARHGAP42 Gene

  1. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. (PMID: 24335996) Bai X. … Taylor J.M. (Nat Commun 2013) 3 4 67
  2. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. (PMID: 18954304) Eberth A. … Ahmadian M.R. (Biochem. J. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genome wide association study of age at menarche in the Japanese population. (PMID: 23667675) Tanikawa C. … Matsuda K. (PLoS ONE 2013) 3

Products for ARHGAP42 Gene

Sources for ARHGAP42 Gene