ARHGAP42 Gene
protein-coding GIFtS: 38
GCID: GC11P100559
|
|
Rho GTPase activating protein 42
| |
Aliases for ARHGAP42 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 421 2 | | GRAF31 2 | | Rho-Type GTPase-Activating Protein 422 3 | | FLJ328101 | | Rho GTPase-Activating Protein 422 | | Rho GTPase-Activating Protein 10-Like3 |
Export aliases for ARHGAP42 gene to outside databasesPrevious GC identifer: GC11P096494 |
Summaries for ARHGAP42 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28Function: May act as a GTPase activator (By similarity)
|
Genomic Views for ARHGAP42 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for ARHGAP42 Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP42
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP42 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.1 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q22.1ARHGAP42 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P100559: view genomic region
(about GC identifiers)
Start:
|
100,558,384 bp from pter |
End:
|
100,861,656 bp from pter |
Size:
|
303,273 bases |
Orientation:
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plus strand |
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Proteins for ARHGAP42 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 42 Size: 874 amino acids; 98569 Da
Sequence caution: Sequence=BAB71456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;Sequence=BF511460; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in theC-terminal part;
Secondary accessions: Q96M56Explore the universe of human proteins at neXtProt for ARHGAP42: NX_A6NI28
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NI28 ARHGAP42 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689645.2 ENSEMBL proteins: ENSP00000431776 ENSP00000434304 ENSP00000435961 ENSP00000298815 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ARHGAP42 for ontologies About GeneDecksing
ARHGAP42 Antibody Products: Assay Products for ARHGAP42: |
Protein
Domains / Families for ARHGAP42 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP42 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NI28ProtoNet protein and cluster: A6NI28 UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28Similarity: Contains 1 BAR domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 Rho-GAP domainSimilarity: Contains 1 SH3 domain |
Function for ARHGAP42 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RHG42_HUMAN, A6NI28Function: May act as a GTPase activator (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGAP42 (NM_152432) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP42 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP42  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP42 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ARHGAP42 for ontologies About GeneDecksing
|
Pathways & Interactions for ARHGAP42 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Cell Signaling Technology (CST) Pathway for ARHGAP42
ARHGAP42 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP42
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0046847 | filopodium assembly |
IEA | -- |
ARHGAP42 for ontologies About GeneDecksing
|
Drugs & Compounds for ARHGAP42 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ARHGAP42 Search CenterWatch for drugs/clinical trials and news about ARHGAP42 / RHG42 
|
Transcripts for ARHGAP42 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ARHGAP42 gene: NM_152432.2 Unigene Cluster for ARHGAP42: Rho GTPase activating protein 42 Hs.741465 [show with all ESTs]Unigene Representative Sequence: NM_1524328 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524892 ENST00000534060 ENST00000529406 ENST00000524649 ENST00000525558 ENST00000531183 ENST00000529535(uc001pgc.2) ENST00000298815(uc001pge.2 uc001pgd.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGAP42 (NM_152432) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP42 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP42  |
Additional cDNA sequence: AF143327.1 AK023666.1 AK057372.1 10 DOTS entries: DT.455387 DT.95155708 DT.75151139 DT.101958866 DT.40108558 DT.100725604 DT.120736455 DT.305930 DT.75171666 DT.91705805 24/78 AceView cDNA sequences (see all 78): BQ187761 CK824101 BM564678 CB044016 CF552909 BF513771 CR620896 AA406599 BM726747 AA417982 AA278669 N30408 BX116126 AA282736 BM894179 AI417838 AW340014 BM014001 NM_032021 AL701071 BM804259 BU146672 AA348796 BF439533 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP42 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for ARHGAP42
|
Expression for ARHGAP42 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP42 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATTTTCTTTT
About this image See ARHGAP42 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARHGAP42
SOURCE GeneReport for Unigene cluster: Hs.741465 SABiosciences Custom PCR Arrays for ARHGAP42
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP42 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP42 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP42 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP42 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP42 |
Orthologs for ARHGAP42 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP42 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ARHGAP421 |
Rho GTPase activating protein 42 |
81.88(n) 92.79(a) |
  |
418990 XM_417185.3 XP_417185.3 |
lizard (Anolis carolinensis) |
Reptilia |
ARHGAP426 |
-- |
89(a) |
1 ↔ 1 |
3(193007784-193094047) |
zebrafish (Danio rerio) |
Actinopterygii |
BI845319.12 |
-- |
70.19(n) |
  |
BI845319.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Graf6 |
Graf |
30(a) |
1 → many |
X(15645707-15654741) |
worm (Caenorhabditis elegans) |
Secernentea |
T04C9.16 |
Protein T04C9.1, isoform c |
32(a) |
1 → many |
III(5993181-6006318) |
ENSEMBL Gene Tree for ARHGAP42 (if available) TreeFam Gene Tree for ARHGAP42 (if available)  |
Paralogs for ARHGAP42 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ARHGAP42 gene
- HMHA12 ARHGAP212 ARHGAP272 ARHGAP102 CHN22 ARHGAP232 ARHGAP92 ARHGAP292
- CHN12 ARHGAP262 ARHGAP152 ARHGAP122 OPHN12 GMIP2
14 SIMAP similar genes for ARHGAP42 using alignment to 5 protein entries: RHG42_HUMAN (see all proteins):GRAF OPHN1 ARHGAP12 ARHGAP26 CHN2 ARHGAP31 CHN1 ARHGAP5 ARHGAP21 ARHGAP10 ARHGAP24 ARHGAP23 DKFZp667D142 ARHGAP9
ARHGAP42 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for ARHGAP42 PGOHUM00000247695 PGOHUM00000248032 PGOHUM00000246371 PGOHUM00000240311 PGOHUM00000240906
|
Genomic Variants for ARHGAP42 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP42 (100558384 - 100808384 bp, first 250kb of ARHGAP42)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARHGAP42: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP42 |
|
Disorders
/ Diseases for ARHGAP42 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP42 for disorders About MalaCards
ARHGAP42 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ARHGAP42 (0 documents) Export disorders for ARHGAP42 gene to outside databases
|
Publications for ARHGAP42 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP42 gene integrated from 9 sources: (articles sorted by number of sources associating them with ARHGAP42) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A BAR domain-mediated autoinhibitory mechanism for Rh oGAPs of the GRAF family. (PubMed id 18954304)1, 3 Eberth A....Ahmadian M.R. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
- Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1 ....Johnson T. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for ARHGAP42 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ARHGAP42 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP42 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGAP42 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ARHGAP42 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGAP42 gene: Search GeneIP for patents involving ARHGAP42
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ARHGAP42 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGAP42 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP42 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP42 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ARHGAP42 | | OriGene 3'-UTR Clone for ARHGAP42 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP42 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |
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 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP42 |
|  |  |  | | | Search ThermoFisher Antibodies for ARHGAP42 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP42 |
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