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Aliases for ARHGAP40 Gene

Aliases for ARHGAP40 Gene

  • Rho GTPase Activating Protein 40 2 3 5
  • Rho-Type GTPase-Activating Protein 40 3 4
  • C20orf95 3 4
  • Chromosome 20 Open Reading Frame 95 2
  • DJ1100H13.4 3

External Ids for ARHGAP40 Gene

Previous HGNC Symbols for ARHGAP40 Gene

  • C20orf95

Previous GeneCards Identifiers for ARHGAP40 Gene

  • GC20P037252
  • GC20P033967

Summaries for ARHGAP40 Gene

GeneCards Summary for ARHGAP40 Gene

ARHGAP40 (Rho GTPase Activating Protein 40) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP40 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP40 Gene

Genomics for ARHGAP40 Gene

Regulatory Elements for ARHGAP40 Gene

Enhancers for ARHGAP40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP40 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP40 Gene

38,601,934 bp from pter
38,651,035 bp from pter
49,102 bases
Plus strand

Genomic View for ARHGAP40 Gene

Genes around ARHGAP40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP40 Gene

Proteins for ARHGAP40 Gene

  • Protein details for ARHGAP40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 40
    Protein Accession:

    Protein attributes for ARHGAP40 Gene

    622 amino acids
    Molecular mass:
    68908 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI19168.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ARHGAP40 Gene

Proteomics data for ARHGAP40 Gene at MOPED

Post-translational modifications for ARHGAP40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP40 Gene

No data available for DME Specific Peptides for ARHGAP40 Gene

Domains & Families for ARHGAP40 Gene

Gene Families for ARHGAP40 Gene

Protein Domains for ARHGAP40 Gene

Suggested Antigen Peptide Sequences for ARHGAP40 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP40: view

Function for ARHGAP40 Gene

Molecular function for ARHGAP40 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes for ARHGAP40 Gene

genes like me logo Genes that share phenotypes with ARHGAP40: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP40 Gene

Localization for ARHGAP40 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP40 Gene COMPARTMENTS Subcellular localization image for ARHGAP40 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP40 Gene

Pathways & Interactions for ARHGAP40 Gene

genes like me logo Genes that share pathways with ARHGAP40: view

Pathways by source for ARHGAP40 Gene

3 Reactome pathways for ARHGAP40 Gene

Interacting Proteins for ARHGAP40 Gene

Gene Ontology (GO) - Biological Process for ARHGAP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP40: view

No data available for SIGNOR curated interactions for ARHGAP40 Gene

Drugs & Compounds for ARHGAP40 Gene

No Compound Related Data Available

Transcripts for ARHGAP40 Gene

mRNA/cDNA for ARHGAP40 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP40 Gene

Rho GTPase activating protein 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP40 Gene

No ASD Table

Relevant External Links for ARHGAP40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP40 Gene

mRNA expression in normal human tissues for ARHGAP40 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP40 Gene

This gene is overexpressed in Breast - Mammary Tissue (x10.6), Esophagus - Mucosa (x10.3), Skin - Sun Exposed (Lower leg) (x9.4), and Skin - Not Sun Exposed (Suprapubic) (x8.4).

Protein differential expression in normal tissues from HIPED for ARHGAP40 Gene

This gene is overexpressed in Liver, secretome (37.0), Platelet (19.1), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGAP40 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP40 Gene Hs.451997

genes like me logo Genes that share expression patterns with ARHGAP40: view

Protein tissue co-expression partners for ARHGAP40 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP40 Gene

Orthologs for ARHGAP40 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP40 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Arhgap40 35
  • 80.24 (n)
  • 75.87 (a)
Arhgap40 16
Arhgap40 36
  • 69 (a)
(Pan troglodytes)
Mammalia ARHGAP40 35
  • 98.76 (n)
  • 97.83 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Arhgap40 35
  • 78.77 (n)
  • 73.88 (a)
(Monodelphis domestica)
Mammalia ARHGAP40 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 70 (a)
(Gallus gallus)
Aves ARHGAP40 35
  • 64.7 (n)
  • 61.58 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia ARHGAP40 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap40 35
  • 57.93 (n)
  • 52.08 (a)
Str.5487 35
(Danio rerio)
Actinopterygii LOC101886014 35
  • 57.68 (n)
  • 54.45 (a)
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for ARHGAP40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP40 Gene

Gene Tree for ARHGAP40 (if available)
Gene Tree for ARHGAP40 (if available)

Paralogs for ARHGAP40 Gene

(5) SIMAP similar genes for ARHGAP40 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARHGAP40: view

Variants for ARHGAP40 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP40 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6100455 - 38,627,213(+) ATTCA(A/G)GGGTA reference, missense
rs6070872 - 38,643,738(+) GGCCC(A/G/T)GGAAC reference, missense
rs16987460 - 38,643,887(+) TGGTG(A/C)ACTAC reference, missense
rs85151 -- 38,617,315(-) CCATG(C/T)AAAGC intron-variant
rs117796 -- 38,646,218(-) GCCCT(C/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP40 Gene

Variant ID Type Subtype PubMed ID
nsv3372 CNV Insertion 18451855
esv1002417 CNV Deletion 20482838

Variation tolerance for ARHGAP40 Gene

Gene Damage Index Score: 5.79; 73.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP40 Gene

Disorders for ARHGAP40 Gene

Relevant External Links for ARHGAP40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGAP40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP40 Gene

Publications for ARHGAP40 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4 67

Products for ARHGAP40 Gene

Sources for ARHGAP40 Gene