ARHGAP40 Gene
protein-coding GIFtS : 40 GCID: GC20 P037252 (predicted)
Rho GTPase activating protein 40 chromosome 20 open reading frame 95 )C20orf95 )
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Aliasesfor ARHGAP40 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Rho GTPase Activating Protein 40 1 2 C20orf951 2 3 DJ1100H13.41 Rho-Type GTPase-Activating Protein 402 3 Chromosome 20 Open Reading Frame 951 Rho GTPase-Activating Protein 402
Export aliases for ARHGAP40 gene to outside databases Previous GC identifer: GC20P033967
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Summariesfor ARHGAP40 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RHG40_HUMAN, Q5TG30 Function : GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)
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Genomic Viewsfor ARHGAP40 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011362.10 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for ARHGAP40 Other transcription factors Search SABiosciences Chromatin IP Primers for ARHGAP40 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23 ARHGAP40 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P037252: view genomic region
(about GC identifiers )
Start: 37,230,577 bp from pter End:
37,279,678 bp from pter
Size: 49,102 bases Orientation:
plus strand
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Proteinsfor ARHGAP40 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RHG40_HUMAN, Q5TG30 See
protein sequence )Recommended Name: Size : 622 amino acids; 68908 DaSequence caution : Sequence=CAI19168.2; Type=Erroneous gene model prediction;Explore the universe of human proteins at neXtProt for ARHGAP40: NX_Q5TG30 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5TG30 ARHGAP40 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001157903.1 ENSEMBL proteins: ENSP00000243967 ENSP00000362443 ENSP00000414822 ENSP00000362442 Reactome Protein details: Q5TG30 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005829 cytosol
TAS --
About GeneDecksing ARHGAP40 Antibody Products: Assay Products for ARHGAP40:
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Protein
Domains /for ARHGAP40 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5TG30 ProtoNet protein and cluster: Q5TG30
1 Blocks protein family : IPB000198 UniProtKB/Swiss-Prot: RHG40_HUMAN, Q5TG30 Similarity : Contains 1 Rho-GAP domain
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Functionfor ARHGAP40 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RHG40_HUMAN, Q5TG30 Function : GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARHGAP40 (NM_001164431 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP40 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP40
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP40
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005096 GTPase activator activity
IEA --
About GeneDecksing 1 GenomeRNAi human phenotype for ARHGAP40 :
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Pathways & Interactionsfor ARHGAP40 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell death signalling via NRAGE, NRIF and NADE 2 Signaling by GPCR
Pathway sources See GeneCards unified pathways Show all pathways 3 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP40 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/34 Interacting proteins for ARHGAP40 (ENSP00000362442 4 via UniProtKB, MINT, STRING , and/or I2D (see all 34 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
TAS -- GO:0051056 regulation of small GTPase mediated signal transduction
TAS --
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Drugs & Compoundsfor ARHGAP40 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARHGAP40 ARHGAP40 / RHG40
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Transcriptsfor ARHGAP40 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARHGAP40 gene: NM_001164431.1 Unigene Cluster for ARHGAP40:
Rho GTPase activating protein 40 Hs.451997 [show with all ESTs ] Unigene Representative Sequence: NM_001164431 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000243967 ENST00000373346 ENST00000414158 ENST00000373345 (uc021wdn.1 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARHGAP40 (NM_001164431 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP40 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP40
4 DOTS entries : DT.99933748 DT.95259192
DT.99933753 DT.120823960 9 AceView cDNA sequences :
BU633157 BU196328 AI651005 AA633408 AW629759 CD389710 AW749955 AL935102 BF857264 GeneLoc Exon Structure
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Expression for ARHGAP40 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARHGAP40 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ARHGAP40 expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Experimental details:
In-situ hybridization
See ARHGAP40 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.451997 SABiosciences Custom PCR Arrays for ARHGAP40 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP40
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Orthologsfor ARHGAP40 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ARHGAP40 gene from 5/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ARHGAP401
Rho GTPase activating protein 40
64.75(n) 61.58(a)
419168 NM_001145016.1 NP_001138488.1
lizard Reptilia ARHGAP406
--
53(a)
1 ↔ 1
4(141224678-141254205)
tropical clawed frog Amphibia Str.54872
Transcribed sequence with weak similarity to protein more
75.71(n)
BQ523285.1
zebrafish Actinopterygii CABZ01081866.16
--
30(a)
1 ↔ 1
6(59823389-59840041)
fruit fly Insecta CG170826
--
14(a)
1 → many
2R(631836-645548)
ENSEMBL Gene Tree for ARHGAP40 (if available)TreeFam Gene Tree for ARHGAP40 (if available)
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Paralogsfor ARHGAP40 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARHGAP40 gene ARHGAP6 2 ARHGAP36 2 STARD13 2 ARHGAP18 2 ARHGAP11A 2 DLC1 2 ARHGAP28 2 ARHGAP11B 2 STARD8 2 5 SIMAP similar genes for ARHGAP40 using alignment to 4 protein entries: RHG40_HUMAN (see all proteins ):ARHGAP12 ARHGAP28 ARHGAP18 ARHGAP21 ARHGAP9 About GeneDecksing
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Genomic Variantsfor ARHGAP40 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 20 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ARHGAP40 (37230577 - 37279678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARHGAP40: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ARHGAP40 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor ARHGAP40 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed article for ARHGAP40 gene integrated from 9 sources :(articles sorted by number of sources associating them with ARHGAP40) Utopia : connect your pdf to the dynamic
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 2 (2001)
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External Searches for ARHGAP40 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARHGAP40 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARHGAP40 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ARHGAP40 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ARHGAP40 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ARHGAP40 gene: ARHGAP40 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARHGAP40 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat Browse OriGene genome-wide validated SYBR primer pairs OriGene Protein Over-expression Lysate for ARHGAP40 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARHGAP40 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARHGAP40 OriGene Custom Protein Services for ARHGAP40 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP40 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
ARHGAP40 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP40
Search ThermoFisher Antibodies for ARHGAP40
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP40
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Expression for ARHGAP40
Function for ARHGAP40
Genomic Views for ARHGAP40
Intellectual Property for ARHGAP40
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
