Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP40 Gene

Aliases for ARHGAP40 Gene

  • Rho GTPase Activating Protein 40 2 3 5
  • Rho-Type GTPase-Activating Protein 40 3 4
  • C20orf95 3 4
  • Chromosome 20 Open Reading Frame 95 2
  • Rho GTPase-Activating Protein 40 3
  • DJ1100H13.4 3

External Ids for ARHGAP40 Gene

Previous HGNC Symbols for ARHGAP40 Gene

  • C20orf95

Previous GeneCards Identifiers for ARHGAP40 Gene

  • GC20P037252
  • GC20P033967

Summaries for ARHGAP40 Gene

GeneCards Summary for ARHGAP40 Gene

ARHGAP40 (Rho GTPase Activating Protein 40) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP18.

UniProtKB/Swiss-Prot for ARHGAP40 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP40 Gene

Genomics for ARHGAP40 Gene

Regulatory Elements for ARHGAP40 Gene

Enhancers for ARHGAP40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G038600 1.5 FANTOM5 Ensembl ENCODE 37.1 -0.3 -345 1.2 ARID4B KLF17 RAD21 EGR1 SCRT2 EGR2 SP3 ZNF398 ZNF341 ZNF580 ARHGAP40 ADIG
GH20G038628 0.6 ENCODE 48.7 +27.0 26998 0.6 BCOR ADNP NR2C1 ZMYM3 KDM1A ZNF518A SP7 NR2C2 GABPA ARHGAP40 GC20M038618 PIR44827
GH20G038598 0.8 ENCODE 31.8 -2.5 -2507 1.2 ELF3 NFIB RBBP5 ZIC2 ZNF644 ZNF48 TEAD3 ZNF121 GLIS2 ELK1 ARHGAP40 ADIG
GH20G038665 0.9 ENCODE 15.6 +64.4 64446 1.3 HDGF SIN3A TCF12 GATA2 FOS SP3 REST SMARCB1 ZNF592 CREB3 ARHGAP40 SNORA71B SNORA71A ENSG00000224635 PIR44827 GC20M038618
GH20G038803 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +204.7 204660 6.3 HDGF PKNOX1 ATF1 WRNIP1 FEZF1 TCF12 GLIS2 GATA2 ZNF143 ZNF207 PPP1R16B ACTR5 ARHGAP40 RALGAPB DHX35 RN7SL116P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP40 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP40 Gene

Chromosome:
20
Start:
38,601,934 bp from pter
End:
38,651,035 bp from pter
Size:
49,102 bases
Orientation:
Plus strand

Genomic View for ARHGAP40 Gene

Genes around ARHGAP40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP40 Gene

Proteins for ARHGAP40 Gene

  • Protein details for ARHGAP40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TG30-RHG40_HUMAN
    Recommended name:
    Rho GTPase-activating protein 40
    Protein Accession:
    Q5TG30

    Protein attributes for ARHGAP40 Gene

    Size:
    622 amino acids
    Molecular mass:
    68908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI19168.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ARHGAP40 Gene

Post-translational modifications for ARHGAP40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP40 Gene

No data available for DME Specific Peptides for ARHGAP40 Gene

Domains & Families for ARHGAP40 Gene

Gene Families for ARHGAP40 Gene

Protein Domains for ARHGAP40 Gene

Suggested Antigen Peptide Sequences for ARHGAP40 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP40: view

No data available for UniProtKB/Swiss-Prot for ARHGAP40 Gene

Function for ARHGAP40 Gene

Molecular function for ARHGAP40 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP40: view

Phenotypes for ARHGAP40 Gene

genes like me logo Genes that share phenotypes with ARHGAP40: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP40 Gene

Localization for ARHGAP40 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP40 gene
Compartment Confidence
cytosol 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGAP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP40: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP40 Gene

Pathways & Interactions for ARHGAP40 Gene

genes like me logo Genes that share pathways with ARHGAP40: view

Pathways by source for ARHGAP40 Gene

3 Reactome pathways for ARHGAP40 Gene

Interacting Proteins for ARHGAP40 Gene

Gene Ontology (GO) - Biological Process for ARHGAP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP40: view

No data available for SIGNOR curated interactions for ARHGAP40 Gene

Drugs & Compounds for ARHGAP40 Gene

No Compound Related Data Available

Transcripts for ARHGAP40 Gene

mRNA/cDNA for ARHGAP40 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP40 Gene

Rho GTPase activating protein 40:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP40 Gene

No ASD Table

Relevant External Links for ARHGAP40 Gene

GeneLoc Exon Structure for
ARHGAP40
ECgene alternative splicing isoforms for
ARHGAP40

Expression for ARHGAP40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP40 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP40 Gene

This gene is overexpressed in Breast - Mammary Tissue (x10.6), Esophagus - Mucosa (x10.3), Skin - Sun Exposed (Lower leg) (x9.4), and Skin - Not Sun Exposed (Suprapubic) (x8.4).

Protein differential expression in normal tissues from HIPED for ARHGAP40 Gene

This gene is overexpressed in Liver, secretome (37.0), Platelet (19.1), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP40 Gene



Protein tissue co-expression partners for ARHGAP40 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP40 Gene:

ARHGAP40

SOURCE GeneReport for Unigene cluster for ARHGAP40 Gene:

Hs.451997
genes like me logo Genes that share expression patterns with ARHGAP40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP40 Gene

Orthologs for ARHGAP40 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP40 34 35
  • 98.76 (n)
mouse
(Mus musculus)
Mammalia Arhgap40 34 16 35
  • 80.24 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap40 34
  • 78.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARHGAP40 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP40 34 35
  • 64.7 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP40 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap40 34
  • 57.93 (n)
Str.5487 34
zebrafish
(Danio rerio)
Actinopterygii LOC101886014 34
  • 57.68 (n)
ARHGAP40 35
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17082 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for ARHGAP40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP40 Gene

ENSEMBL:
Gene Tree for ARHGAP40 (if available)
TreeFam:
Gene Tree for ARHGAP40 (if available)

Paralogs for ARHGAP40 Gene

(5) SIMAP similar genes for ARHGAP40 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARHGAP40: view

Variants for ARHGAP40 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP40 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000017413 -- 38,611,605(+) CGGAG(C/T)CTTGC intron-variant
rs1000044455 -- 38,617,501(+) CGTGC(C/T)CACAG intron-variant
rs1000059092 -- 38,619,244(+) AGGGT(-/C)CTGGG intron-variant
rs1000091014 -- 38,600,206(+) ACCTA(C/T)CCATC upstream-variant-2KB
rs1000153454 -- 38,610,671(+) TTTGC(A/G)ATTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP40 Gene

Variant ID Type Subtype PubMed ID
esv1002417 CNV deletion 20482838
nsv1058457 CNV loss 25217958
nsv3372 CNV insertion 18451855
nsv475283 CNV novel sequence insertion 20440878

Variation tolerance for ARHGAP40 Gene

Gene Damage Index Score: 5.79; 73.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP40 Gene

Disorders for ARHGAP40 Gene

Relevant External Links for ARHGAP40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP40

No disorders were found for ARHGAP40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP40 Gene

Publications for ARHGAP40 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4 64

Products for ARHGAP40 Gene

Sources for ARHGAP40 Gene

Content
Loading form....