Aliases for ARHGAP4 Gene
External Ids for ARHGAP4 Gene
Previous GeneCards Identifiers for ARHGAP4 Gene
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for ARHGAP4 Gene
ARHGAP4 (Rho GTPase Activating Protein 4) is a Protein Coding gene. Diseases associated with ARHGAP4 include Diabetes Insipidus and Diabetes Insipidus, Nephrogenic. Among its related pathways are Regulation of RhoA activity and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP3.
UniProtKB/Swiss-Prot for ARHGAP4 Gene
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.