ARHGAP4 Gene
protein-coding GIFtS: 61
GCID: GC0XM153172
|
|
Rho GTPase activating protein 4
| |
Aliases
for ARHGAP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 41 2 | | KIAA01311 3 | | P1151 | | Rho-Type GTPase-Activating Protein 42 3 | | RGC12 3 5 | | Rho-GAP Hematopoietic Protein C12 3 | | C11 2 | | Rho GTPase-Activating Protein 42 | | RhoGAP41 2 | | RHOGAP43 | | SrGAP41 2 | | |
Export aliases for ARHGAP4 gene to outside databasesPrevious GC identifers: GC0XM147310 GC0XM149627 GC0XM150758 GC0XM151640 GC0XM152693 GC0XM152826 GC0XM141824 |
Summaries
for ARHGAP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGAP4:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-bindingproteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to theGolgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases invitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetesinsipidus. Multiple transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Sep 2009)
UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171Function: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells
Gene Wiki entry for ARHGAP4
|
Genomic Views
for ARHGAP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGAP4 gene promoter:
NF-1 NF-1/L Elk-1 AML1a AP-1 Pax-5 Tal-1beta Ik-3 E47 ARP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28ARHGAP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153172: view genomic region
(about GC identifiers)
Start:
|
153,172,821 bp from pter |
End:
|
153,200,452 bp from pter |
Size:
|
27,632 bases |
Orientation:
|
minus strand |
|
Proteins
for ARHGAP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 4 Size: 946 amino acids; 105026 Da
Subcellular location: Cytoplasm. Note=Just below the plasma membrane
1 PDB 3D structure from  and Proteopedia  for ARHGAP4:2EPD (3D)
Secondary accessions: Q14144 Q86UY3Alternative splicing: 2 isoforms: P98171-1 P98171-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARHGAP4: NX_P98171
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P98171
ARHGAP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001158213.1 NP_001657.3
ENSEMBL proteins: ENSP00000377322 ENSP00000359045 ENSP00000397533 ENSP00000203786 ENSP00000359033 ENSP00000385042 ENSP00000412437 ENSP00000408656 ENSP00000398019 ENSP00000411712 ENSP00000398259 ENSP00000413782 ENSP00000444169 Reactome Protein details: P98171
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ARHGAP4 for ontologies About GeneDecksing
ARHGAP4 Antibody Products:
Assay Products for ARHGAP4: |
Protein
Domains /
Families
for ARHGAP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P98171ProtoNet protein and cluster: P98171 3 Blocks protein families: IPB000198 RhoGAP domain IPB001060 Cdc15/Fes/CIP4 IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171Similarity: Contains 1 FCH domainSimilarity: Contains 1 Rho-GAP domainSimilarity: Contains 1 SH3 domain |
Function
for ARHGAP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171Function: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells Genatlas biochemistry entry for ARHGAP4:Rho GTPase activating protein 4,155kDa,aplysia related,involved in signal transduction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGAP4 (NM_001666) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ARHGAP4 for ontologies About GeneDecksing
|
Pathways & Interactions
for ARHGAP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | G12-G13 in Cellular Signaling | | | 4 | Regulation of RhoA activity | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGAP4
1  BioSystems Pathway for ARHGAP4
5/10 
Reactome Pathways for ARHGAP4 (see all 10)
ARHGAP4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/94 Interacting proteins for ARHGAP4 (P981712, 3 ENSP000002037864) via UniProtKB, MINT, STRING, and/or I2D (see all 94)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ARHGAP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGAP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGAP4 for compounds About GeneDecksing
 Browse Tocris compounds for ARHGAP4
2 Novoseek chemical compound relationships for ARHGAP4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| arginine |
42.7 |
3 |
15258251 (2), 16954208 (1) |
| gtp |
42.5 |
1 |
8570618 (1) |
Search CenterWatch for drugs/clinical trials and news about ARHGAP4 / RHG04
|
Transcripts
for ARHGAP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGAP4 gene (2 alternative transcripts): NM_001164741.1 NM_001666.4 Unigene Cluster for ARHGAP4: Rho GTPase activating protein 4 Hs.701324 [show with all ESTs]Unigene Representative Sequence: NM_00116474118/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000393721 ENST00000370028(uc011mzf.2 uc004fjl.2 uc004fjk.2 uc010nup.2)
ENST00000420383 ENST00000350060 ENST00000494397 ENST00000466928 ENST00000370016
ENST00000470209 ENST00000494302 ENST00000404127 ENST00000454164 ENST00000467421
ENST00000442172 ENST00000461739 ENST00000494813 ENST00000422918 ENST00000463905
ENST00000461052
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGAP4 (NM_001666) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP4 |
Additional cDNA sequence: AK294562.1 BC023626.2 BC052303.1 D50921.1 X78817.1 15 DOTS entries: DT.411668 DT.97843209 DT.101958173 DT.100774974 DT.121319518 DT.121319484 DT.91975975 DT.100786841 DT.100680754 DT.100786844 DT.102829699 DT.121319529 DT.86854991 DT.100786848 DT.121319519 24/397 AceView cDNA sequences (see all 397): BX384178 AA532862 BU538872 BX118050 BC023626 CK904981 AW467767 AY183134 BE504291 BM989017 BQ676936 BI858632 CR612890 D50921 AW591760 AA505857 BM987524 BQ066370 AU132372 BM818474 BQ962748 BM790927 BF219692 CK904982
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP4 (see all 18) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | | | - | | | | | | | | - | | |
| SP4: | | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGAP4
|
Expression
for ARHGAP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCTGTGT
About this image
See ARHGAP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP4
SOURCE GeneReport for Unigene cluster: Hs.701324
UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171Tissue specificity: Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lungand various fetal tissues
SABiosciences Custom PCR Arrays for ARHGAP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP4 |
Orthologs
for ARHGAP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP4 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGAP46 |
-- |
56(a) |
1 ↔ 1 |
2(88241230-88274195) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5612311 |
Slit-Robo GAP homolog family member (srgp-1)-like |
56.94(n)
50.58(a) |
|
561231 XM_684637.4 XP_689729.2 |
honey bee
(Apis mellifera) |
Insecta |
---- |
-- |
34(a)26(a) |
many ↔ manymany ↔ many |
GroupUn.6494(193-4365) GroupUn.138(27553-37557) |
worm
(Caenorhabditis elegans) |
Secernentea |
F12F6.53 |
chimaerin like |
32(a) |
|
IV(11570715-11578530) -- |
ENSEMBL Gene Tree for ARHGAP4 (if available)
TreeFam Gene Tree for ARHGAP4 (if available) |
Paralogs
for ARHGAP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGAP4 gene
- SRGAP12 ARHGAP52 ARHGAP172 ARHGAP242 ARHGAP222 SRGAP32 ARHGAP352 ARHGAP442
- SH3BP12 SRGAP22 ARHGAP252
15 SIMAP similar genes for ARHGAP4 using alignment to 12 protein entries: RHG04_HUMAN (see all proteins):C1 SORBS3 SRGAP2C KIAA1156 ARHGAP30 SRGAP3
SRGAP1 ARHGAP5 SRGAP2 ARHGAP21 CHN2 ARHGAP24
CHN1 ARHGAP31 ARHGAP12
ARHGAP4 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGAP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP4 (153172821 - 153200452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGAP4: --
Locus Specific Mutation Databases (LSDB): ARHGAP4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP4 |
|
Disorders
/ Diseases
for ARHGAP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP4 for disorders About GeneDecksing
OMIM gene information: 300023
OMIM disorders: --
7  diseases for ARHGAP4: About MalaCardsnephrogenic diabetes insipidus diabetes insipidus hepatitis b hepatocellular carcinoma
hepatitis carcinoma leukemia
1 disease from the University of Copenhagen DISEASES database for ARHGAP4:Nephrogenic diabetes insipidus 1 Novoseek disease relationship for ARHGAP4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diabetes insipidus nephrogenic |
85.9 |
4 |
11754100 (2), 18489790 (1), 10425039 (1) |
Human Genome Epidemiology (HuGE) Navigator: ARHGAP4 (4 documents)
Export disorders for ARHGAP4 gene to outside databases
|
Publications
for ARHGAP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP4 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with ARHGAP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (PubMed id 8570618)1, 2, 3, 9 Tribioli C.... Pelicci P.-G. (1996)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
- Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. (PubMed id 7981673)1, 2 Tribioli C.... Toniolo D. (1994)
- Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes. (PubMed id 18489790)1, 9 Fujimoto M....Noguchi E. (2008)
- Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. (PubMed id 11754100)1, 9 Demura M....Mabuchi H. (2002)
- FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PubMed id 12736724)1, 9 Katoh M. and Katoh M. (2003)
- A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectu al disability. (PubMed id 22965914)1 Huang L....Gibson K. (2012)
- PRL-1 protein promotes ERK1/2 and RhoA protein activat ion through a non-canonical interaction with the Src homology 3 domain of p115 R ho GTPase-activating protein. (PubMed id 22009749)1 Bai Y....Zhang Z.Y. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for ARHGAP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGAP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGAP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for ARHGAP4 gene:
Search GeneIP for patents involving ARHGAP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGAP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for ARHGAP4 | | OriGene shRNA RFP for ARHGAP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP4 | | | OriGene Protein Over-expression Lysate for ARHGAP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGAP4 | | OriGene 3'-UTR Clone for ARHGAP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGAP4 | | OriGene Custom Protein Services for ARHGAP4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP4 |
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| | | | Search Tocris compounds for ARHGAP4 |
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 | | | ARHGAP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP4 |
|  |  |  | | | | ThermoFisher Antibodies for ARHGAP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP4 |
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