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ARHGAP4 Gene

protein-coding   GIFtS: 62
GCID: GC0XM153172

Rho GTPase Activating Protein 4

  See ARHGAP4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 41 2     RhoGAP42
Rho-GAP Hematopoietic Protein C11 2 3     SrGAP42
RGC12 3 5     Rho GTPase-Activating Protein 42
Rho-Type GTPase-Activating Protein 42 3     KIAA01313
p1152 3     RHOGAP43
C12     

External Ids:    HGNC: 6741   Entrez Gene: 3932   Ensembl: ENSG000000898207   OMIM: 3000235   UniProtKB: P981713   

Export aliases for ARHGAP4 gene to outside databases

Previous GC identifers: GC0XM147310 GC0XM149627 GC0XM150758 GC0XM151640 GC0XM152693 GC0XM152826 GC0XM141824


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP4 Gene:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small
GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is
localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of
some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with
nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for ARHGAP4 Gene:
ARHGAP4 (Rho GTPase activating protein 4) is a protein-coding gene. Diseases associated with ARHGAP4 include l1 syndrome. GO annotations related to this gene include SH3/SH2 adaptor activity and Rho GTPase activator activity. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171
Function: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells

Gene Wiki entry for ARHGAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP4 gene promoter:
         NF-1   NF-1/L   Elk-1   AML1a   AP-1   Pax-5   Tal-1beta   Ik-3   E47   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP4 promoter sequence
   Search Chromatin IP Primers for ARHGAP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

ARHGAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153172:  view genomic region     (about GC identifiers)

Start:
153,172,821 bp from pter      End:
153,200,452 bp from pter
Size:
27,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 4  
Size: 946 amino acids; 105026 Da
1 PDB 3D structure from and Proteopedia for ARHGAP4:
2EPD (3D)    
Secondary accessions: Q14144 Q86UY3
Alternative splicing: 2 isoforms:  P98171-1   P98171-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP4: NX_P98171

Explore proteomics data for ARHGAP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys443
  • Modification sites at PhosphoSitePlus

  • See ARHGAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158213.1  NP_001657.3  

    ENSEMBL proteins: 
     ENSP00000377322   ENSP00000359045   ENSP00000397533   ENSP00000203786   ENSP00000359033  
     ENSP00000385042   ENSP00000412437   ENSP00000408656   ENSP00000398019   ENSP00000473840  
     ENSP00000411712   ENSP00000473936   ENSP00000398259   ENSP00000413782   ENSP00000444169  
    Reactome Protein details: P98171

    ARHGAP4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGAP4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001060 FCH_dom
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry P98171

    ProtoNet protein and cluster: P98171

    3 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ARHGAP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG04_HUMAN, P98171
    Function: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells

         Genatlas biochemistry entry for ARHGAP4:
    Rho GTPase activating protein 4,155kDa,aplysia related,involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8570618
    GO:0005100Rho GTPase activator activity IEA--
    GO:0005515protein binding IPI16417406
         
    Find genes that share ontologies with ARHGAP4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP4
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    hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ARHGAP4 (NM_001666)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG04_HUMAN, P98171: Cytoplasm. Note=Just below the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion ----

    Find genes that share ontologies with ARHGAP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4Signaling by FGFR
    Signalling by NGF0.71
    5Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35


    Find genes that share SuperPaths with ARHGAP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGAP4
        RhoA Pathway
    G12-G13 in Cellular Signaling
    RhoGDI Pathway

    1 BioSystems Pathway for ARHGAP4
        Regulation of RhoA activity

    3 Reactome Pathways for ARHGAP4
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP4
    Interactions:

        GeneGlobe Interaction Network for ARHGAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP4 (P981712, 3 ENSP000002037864) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASLGP480232, 3, ENSP000003566944MINT-7137092 I2D: score=1 STRING: ENSP00000356694
    NRASP011113, ENSP000003585484I2D: score=1 STRING: ENSP00000358548
    TUBA3EENSP000003181974STRING: ENSP00000318197
    ARAP2ENSP000003028954STRING: ENSP00000302895
    ARAP3ENSP000002394404STRING: ENSP00000239440
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization TAS8570618
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS8570618
    GO:0007399nervous system development ----

    Find genes that share ontologies with ARHGAP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP4 (RHG04)

    2 Novoseek inferred chemical compound relationships for ARHGAP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 42.7 3 15258251 (2), 16954208 (1)
    gtp 42.5 1 8570618 (1)



    Find genes that share compounds with ARHGAP4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP4 gene (2 alternative transcripts): 
    NM_001164741.1  NM_001666.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000393721 ENST00000370028(uc011mzf.2 uc004fjl.2 uc004fjk.2 uc010nup.2)
    ENST00000420383 ENST00000350060 ENST00000494397 ENST00000466928 ENST00000370016
    ENST00000470209 ENST00000494302 ENST00000404127 ENST00000454164 ENST00000467421
    ENST00000442172 ENST00000461739 ENST00000494813 ENST00000422918 ENST00000463905
    ENST00000461052
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ARHGAP4:
    hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP4
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP4
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP4

    Selected AceView cDNA sequences (see all 397):

    CD673134 BM989017 CK821442 AW591760 BQ684140 D50921 AA532862 BX384178 
    BM759805 BM790927 BI917002 AY183135 BM718088 CA313208 BM790999 CB266518 
    AW129725 BE276113 BQ066370 CR612890 BM746660 AW467767 AJ709759 BQ931929 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:                    -                             -                       -                       -                             -                       -   
    SP2:                    -                             -                       -     -                 -                             -                       -   
    SP3:                    -                             -                       -     -                 -                             -                       -   
    SP4:        -     -     -                             -                       -     -                 -                                                         
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:                                      -           -                 -                             -                           
    SP2:                                      -           -                 -                             -                           
    SP3:                                      -     -     -           -     -     -                       -                           
    SP4:                                                                                                                              
    SP5:                                      -     -     -                 -                                                         


    ECgene alternative splicing isoforms for ARHGAP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTGTGT
    ARHGAP4 Expression
    About this image


    ARHGAP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    ARHGAP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP4 Protein Expression

    UniProtKB/Swiss-Prot: RHG04_HUMAN, P98171
    Tissue specificity: Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta,
    lung and various fetal tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ARHGAP4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap41 , 5 Rho GTPase activating protein 41, 5 80.7(n)1
    81.76(a)1
      X (37.45 cM)5
    1712071  NM_138630.21  NP_619536.21 
     738914425 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP46
    Rho GTPase activating protein 4
    57(a)
    1 ↔ 1
    2(88241230-88274195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap41 Rho GTPase activating protein 4 57.7(n)
    52.34(a)
      100170556  NM_001130333.1  NP_001123805.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap4b1 Rho GTPase activating protein 4b 56.33(n)
    50.17(a)
      561231  XM_684637.5  XP_689729.3 


    ENSEMBL Gene Tree for ARHGAP4 (if available)
    TreeFam Gene Tree for ARHGAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP4 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP442  
    SH3BP12  ARHGAP252  SRGAP22  
    15 SIMAP similar genes for ARHGAP4 using alignment to 14 protein entries:     RHG04_HUMAN (see all proteins):
    C1    SORBS3    SRGAP2C    KIAA1156    ARHGAP30    SRGAP3
    SRGAP1    ARHGAP5    SRGAP2    ARHGAP21    CHN2    ARHGAP24
    CHN1    ARHGAP31    ARHGAP12

    Find genes that share paralogs with ARHGAP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP4 (see all 455)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900483821,2
    --153047949(+) CCTCTA/GATCCA 2 -- int10--------
    rs1829763821,2
    --153047976(+) GAGGCA/GGATGG 2 -- int10--------
    rs48984601,2
    C,F,A,H--153047991(+) TCTGAG/ACTCAG 2 -- int111Minor allele frequency- A:0.24NS EA NA WA CSA 425
    rs1872726141,2
    --153048024(+) ACACGA/GTGAAA 2 -- int10--------
    rs1931138921,2
    --153048099(+) TACTTA/GGGAGG 2 -- int10--------
    rs1490136751,2
    --153048303(+) TGGACA/GGAAAA 2 -- int10--------
    rs1838947201,2
    --153048459(+) TTAAAA/GTTGAG 2 -- int10--------
    rs1438295971,2
    C--153048521(+) AGCCCC/TGCCGT 2 -- int10--------
    rs1511068241,2
    --153048571(+) AAGGCC/TATTTT 2 -- int10--------
    rs583004071,2
    C,F--153048575(+) CCATTC/TTGAGA 2 -- int11Minor allele frequency- T:0.00WA 2

    HapMap Linkage Disequilibrium report for ARHGAP4 (153172821 - 153200452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARHGAP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407
    nsv469867CNV Complex16826518

    Locus Specific Mutation Databases (LSDB): ARHGAP4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300023    OMIM disorders: --

    1 disease for ARHGAP4:    
    About MalaCards
    l1 syndrome

    1 disease from the University of Copenhagen DISEASES database for ARHGAP4:
    Nephrogenic diabetes insipidus

    Find genes that share disorders with ARHGAP4           About GenesLikeMe

    1 Novoseek inferred disease relationship for ARHGAP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes insipidus nephrogenic 85.9 4 11754100 (2), 18489790 (1), 10425039 (1)

    Genetic Association Database (GAD): ARHGAP4
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP4 (4 documents)

    Export disorders for ARHGAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP4 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ARHGAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (PubMed id 8570618)1, 2, 3, 9 Tribioli C.... Pelicci P.-G. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    4. Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. (PubMed id 7981673)1, 2 Tribioli C.... Toniolo D. (Hum. Mol. Genet. 1994)
    5. Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes. (PubMed id 18489790)1, 9 Fujimoto M....Noguchi E. (BMC Med. Genet. 2008)
    6. Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. (PubMed id 11754100)1, 9 Demura M....Mabuchi H. (Hum. Mutat. 2002)
    7. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PubMed id 12736724)1, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    8. Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese. (PubMed id 24043878)1 Wong E.H....Sham P.C. (Schizophr Bull 2013)
    9. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. (PubMed id 23182705)1 Han Y....Krackhardt A.M. (J Proteomics 2013)
    10. A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability. (PubMed id 22965914)1 Huang L....Gibson K. (Am. J. Med. Genet. A 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 393 HGNC: 674 AceView: ARHGAP4andARD1 Ensembl:ENSG00000089820 euGenes: HUgn393
    ECgene: ARHGAP4 H-InvDB: ARHGAP4

    (According to HUGE)
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    HUGE: KIAA0131

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGAP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP4 gene:
    Search GeneIP for patents involving ARHGAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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