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Aliases for ARHGAP39 Gene

Aliases for ARHGAP39 Gene

  • Rho GTPase Activating Protein 39 2 3
  • Rho GTPase-Activating Protein 39 3
  • RhoGAP93B Homolog (Drosophila) 2
  • CrossGAP Homolog (Drosophila) 2
  • RhoGAP93B Homolog 3
  • CrossGAP Homolog 3
  • KIAA1688 4
  • CrGAP 3
  • Vilse 3

External Ids for ARHGAP39 Gene

Previous GeneCards Identifiers for ARHGAP39 Gene

  • GC08M145754
  • GC08M140868

Summaries for ARHGAP39 Gene

GeneCards Summary for ARHGAP39 Gene

ARHGAP39 (Rho GTPase Activating Protein 39) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP39 Gene

Genomics for ARHGAP39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP39 Gene

Start:
144,529,179 bp from pter
End:
144,613,506 bp from pter
Size:
84,328 bases
Orientation:
Minus strand

Genomic View for ARHGAP39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP39 Gene

No data available for Regulatory Elements for ARHGAP39 Gene

Proteins for ARHGAP39 Gene

  • Protein details for ARHGAP39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0H5-RHG39_HUMAN
    Recommended name:
    Rho GTPase-activating protein 39
    Protein Accession:
    Q9C0H5
    Secondary Accessions:
    • B4E1I1

    Protein attributes for ARHGAP39 Gene

    Size:
    1083 amino acids
    Molecular mass:
    121286 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21779.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG64793.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP39 Gene

Proteomics data for ARHGAP39 Gene at MOPED

Post-translational modifications for ARHGAP39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP39 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARHGAP39 Gene

Domains for ARHGAP39 Gene

Gene Families for ARHGAP39 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Suggested Antigen Peptide Sequences for ARHGAP39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0H5

UniProtKB/Swiss-Prot:

RHG39_HUMAN :
  • Q9C0H5
Domain:
  • Contains 1 MyTH4 domain.
  • Contains 1 Rho-GAP domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with ARHGAP39: view

Function for ARHGAP39 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGAP39: view

Phenotypes for ARHGAP39 Gene

genes like me logo Genes that share phenotypes with ARHGAP39: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP39 Gene

miRTarBase miRNAs that target ARHGAP39

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP39

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP39 Gene

Localization for ARHGAP39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP39 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP39 Gene COMPARTMENTS Subcellular localization image for ARHGAP39 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ARHGAP39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARHGAP39: view

Pathways for ARHGAP39 Gene

genes like me logo Genes that share pathways with ARHGAP39: view

Pathways by source for ARHGAP39 Gene

Interacting Proteins for ARHGAP39 Gene

Gene Ontology (GO) - Biological Process for ARHGAP39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP39: view

Transcripts for ARHGAP39 Gene

Unigene Clusters for ARHGAP39 Gene

Rho GTPase activating protein 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP39

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP39 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:

Relevant External Links for ARHGAP39 Gene

GeneLoc Exon Structure for
ARHGAP39
ECgene alternative splicing isoforms for
ARHGAP39

Expression for ARHGAP39 Gene

mRNA expression in normal human tissues for ARHGAP39 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP39 Gene

This gene is overexpressed in Nerve - Tibial (4.6) and Testis (4.1).

Protein differential expression in normal tissues for ARHGAP39 Gene

This gene is overexpressed in Frontal cortex (23.5), Lung (14.2), Retina (10.0), Fetal Brain (9.7), and Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP39 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP39 Gene Hs.148988

genes like me logo Genes that share expressions with ARHGAP39: view

Expression partners for ARHGAP39 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP39 Gene

Orthologs for ARHGAP39 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP39 35
  • 87.22 (n)
  • 88.56 (a)
ARHGAP39 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP39 35
  • 86.19 (n)
  • 86.52 (a)
ARHGAP39 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap39 35
  • 84.67 (n)
  • 89.7 (a)
Arhgap39 16
Arhgap39 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP39 35
  • 98.5 (n)
  • 98.56 (a)
ARHGAP39 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap39 35
  • 84.34 (n)
  • 89.79 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP39 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP39 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP39 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP39 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29319 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27236 35
LOC101884459 35
  • 70.14 (n)
  • 71.37 (a)
arhgap39 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP93B 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.4 36
  • 34 (a)
OneToMany
Y92H12BM.1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3354 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2763 36
  • 62 (a)
OneToOne
Species with no ortholog for ARHGAP39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP39 Gene

ENSEMBL:
Gene Tree for ARHGAP39 (if available)
TreeFam:
Gene Tree for ARHGAP39 (if available)

Paralogs for ARHGAP39 Gene

Selected SIMAP similar genes for ARHGAP39 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP39: view

No data available for Paralogs for ARHGAP39 Gene

Variants for ARHGAP39 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP39 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs732843 -- 144,544,567(+) AGAGC(G/T)GCTTG intron-variant
rs1476233 -- 144,535,804(+) GGTGA(C/T)CATAA intron-variant
rs1871530 -- 144,551,472(-) GGTGC(C/G)CAGCA intron-variant
rs1871531 -- 144,551,445(-) TTGAG(C/G)AGGTG intron-variant
rs1975992 -- 144,557,304(-) AATAC(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP39 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv891912 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294
nsv522459 CNV Loss 19592680
dgv1294e201 CNV Deletion 23290073
esv23868 CNV Gain+Loss 19812545
esv1009938 CNV Deletion 20482838
esv1114154 CNV Insertion 17803354
esv2738069 CNV Deletion 23290073
dgv1295e201 CNV Deletion 23290073
esv2738072 CNV Deletion 23290073
esv2738075 CNV Deletion 23290073
esv2738076 CNV Deletion 23290073
nsv831490 CNV Loss 17160897
esv28359 CNV Loss 19812545
esv2666702 CNV Deletion 23128226
esv2738077 CNV Deletion 23290073
esv1657415 CNV Insertion 17803354
esv22509 CNV Loss 19812545
esv2674311 CNV Deletion 23128226
nsv891924 CNV Loss 21882294
nsv891925 CNV Loss 21882294
esv2738078 CNV Deletion 23290073
esv23002 CNV Loss 19812545
esv2670099 CNV Deletion 23128226
dgv1296e201 CNV Deletion 23290073
esv2738080 CNV Deletion 23290073
esv2667076 CNV Deletion 23128226
esv2738082 CNV Deletion 23290073
esv2738083 CNV Deletion 23290073
dgv1297e201 CNV Deletion 23290073
esv2738086 CNV Deletion 23290073
esv2738088 CNV Deletion 23290073

Relevant External Links for ARHGAP39 Gene

HapMap Linkage Disequilibrium report
ARHGAP39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP39 Gene

Disorders for ARHGAP39 Gene

No disorders were found for ARHGAP39 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARHGAP39 Gene

Publications for ARHGAP39 Gene

  1. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. (PMID: 15755809) Hu H. … Bashaw G.J. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ARHGAP39 Gene

Sources for ARHGAP39 Gene

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