ARHGAP39 Gene
protein-coding GIFtS: 49
GCID: GC08M145754
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|
Rho GTPase activating protein 39
| |
Aliases
for ARHGAP39 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 391 2 | | CrossGAP Homolog2 | | CrGAP1 2 | | Rho GTPase-Activating Protein 392 | | Vilse1 2 | | RhoGAP93B Homolog2 | | KIAA16881 3 | | |
Export aliases for ARHGAP39 gene to outside databasesPrevious GC identifer: GC08M140868 |
Summaries
for ARHGAP39 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ARHGAP39 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARHGAP39
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP39
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP39 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3ARHGAP39 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M145754: view genomic region
(about GC identifiers)
Start:
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145,754,563 bp from pter |
End:
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145,911,194 bp from pter |
Size:
|
156,632 bases |
Orientation:
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minus strand |
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Proteins
for ARHGAP39 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHG39_HUMAN, Q9C0H5 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 39 Size: 1083 amino acids; 121286 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB21779.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAG64793.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4E1I1Alternative splicing: 2 isoforms: Q9C0H5-1 Q9C0H5-2 Explore the universe of human proteins at neXtProt for ARHGAP39: NX_Q9C0H5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0H5
ARHGAP39 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079527.1
ENSEMBL proteins: ENSP00000366522 ENSP00000276826 ENSP00000445075 Reactome Protein details: Q9C0H5
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ARHGAP39 for ontologies About GeneDecksing
ARHGAP39 Antibody Products:
Assay Products for ARHGAP39: |
Protein
Domains /
Families
for ARHGAP39 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP39 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0H5ProtoNet protein and cluster: Q9C0H5 2 Blocks protein families: IPB000198 RhoGAP domain IPB000857 Core domain in kinesin and myosin motor
UniProtKB/Swiss-Prot: RHG39_HUMAN, Q9C0H5Similarity: Contains 1 MyTH4 domainSimilarity: Contains 1 Rho-GAP domainSimilarity: Contains 2 WW domains |
Function
for ARHGAP39 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGAP39 (NM_025251) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP39 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP39 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP39 |
1 GenomeRNAi human phenotype for ARHGAP39:
|
Pathways & Interactions
for ARHGAP39 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Cell death signalling via NRAGE, NRIF and NADE | | | 3 | Signaling by GPCR | | | 4 | Axon guidance | | | 5 | Activation of Rac | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for ARHGAP39 (see all 7)
ARHGAP39 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP39
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for ARHGAP39 (Q9C0H53 ENSP000003665224) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0007411 | axon guidance |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
ARHGAP39 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGAP39 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGAP39
Search CenterWatch for drugs/clinical trials and news about ARHGAP39 / RHG39
|
Transcripts
for ARHGAP39 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGAP39 gene: NM_025251.1 Unigene Cluster for ARHGAP39: Rho GTPase activating protein 39 Hs.148988 [show with all ESTs]Unigene Representative Sequence: NM_0252514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377307(uc003zds.1 uc003zdt.1 uc011llk.1) ENST00000276826
ENST00000528810 ENST00000540274
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGAP39 (NM_025251) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP39 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP39 |
Additional cDNA sequence: AB051475.1 AK092501.1 AK296353.1 AK303851.1 BC013071.2 6 DOTS entries: DT.442417 DT.100019193 DT.100810823 DT.120637390 DT.100657905 DT.95220461 24/58 AceView cDNA sequences (see all 58): AW137065 AI699081 BM725022 AW449608 BM747817 BM745840 AK092501 AI560967 BM680233 AB051475 BC013071 AA029072 AX747574 AW207595 AI061260 BU686829 BQ439662 BM852041 AL043239 AW007189 AK126892 AI499666 AI638193 AI638627
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP39 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGAP39
|
Expression
for ARHGAP39 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCCTGAAA
About this image
See ARHGAP39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP39
SOURCE GeneReport for Unigene cluster: Hs.148988
SABiosciences Custom PCR Arrays for ARHGAP39
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP39
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP39 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP39 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP39 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP39 |
Orthologs
for ARHGAP39 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP39 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for ARHGAP39 (if available)
TreeFam Gene Tree for ARHGAP39 (if available) |
Paralogs
for ARHGAP39 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ARHGAP39 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP39 (145754563 - 145911194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGAP39: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP39 |
|
Disorders
/ Diseases
for ARHGAP39 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP39 for disorders About GeneDecksing
2  diseases for ARHGAP39: About MalaCardsacute leukemia leukemia
Export disorders for ARHGAP39 gene to outside databases
|
Publications
for ARHGAP39 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP39 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGAP39) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cross GTPase-activating protein (CrossGAP)/Vilse link s the Roundabout receptor to Rac to regulate midline repulsion. (PubMed id 15755809)1, 3 Hu H....Bashaw G.J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ARHGAP39 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGAP39 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP39 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGAP39 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGAP39 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGAP39 gene:
Search GeneIP for patents involving ARHGAP39
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGAP39 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGAP39 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP39 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP39 | | | OriGene Protein Over-expression Lysate for ARHGAP39 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGAP39 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP39 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGAP39 | | OriGene Custom Protein Services for ARHGAP39 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP39 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP39 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP39 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP39 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP39 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP39 |
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 | | | ARHGAP39 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP39 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP39 |
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