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ARHGAP36 Gene

protein-coding   GIFtS: 49
GCID: GC0XP130192

Rho GTPase Activating Protein 36

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 361 2
Rho GTPase-Activating Protein 362

External Ids:    HGNC: 263881   Entrez Gene: 1587632   Ensembl: ENSG000001472567   UniProtKB: Q6ZRI83   

Export aliases for ARHGAP36 gene to outside databases

Previous GC identifer: GC0XP119585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARHGAP36 Gene:
ARHGAP36 (Rho GTPase activating protein 36) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is STARD13.

UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGAP36
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARHGAP36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq26.1

ARHGAP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP36 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP130192:  view genomic region     (about GC identifiers)

Start:
130,192,216 bp from pter      End:
130,223,857 bp from pter
Size:
31,642 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 36 precursor  
Size: 547 amino acids; 61664 Da
Sequence caution: Sequence=AAH63790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI41400.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7Z234 B7Z439 Q5JRL9 Q5JRM0 Q5JRM1 Q96NU6
Alternative splicing: 5 isoforms:  Q6ZRI8-1   Q6ZRI8-2   Q6ZRI8-3   Q6ZRI8-4   Q6ZRI8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP36: NX_Q6ZRI8

Explore proteomics data for ARHGAP36 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269536.1  NP_659404.2  

    ENSEMBL proteins: 
     ENSP00000276211   ENSP00000359960   ENSP00000409218   ENSP00000408515   ENSP00000359959  
    Reactome Protein details: Q6ZRI8

    ARHGAP36 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGAP36

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZRI8

    ProtoNet protein and cluster: Q6ZRI8

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP36           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG36_HUMAN, Q6ZRI8
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    Find genes that share ontologies with ARHGAP36           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGAP36:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP36
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGAP36
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    miRNA
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    miRTarBase miRNAs that target ARHGAP36:
    hsa-mir-335-5p (MIRT018956)

    Block miRNA regulation of human, mouse, rat ARHGAP36 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP36 (see all 41):
    hsa-miR-19b-2* hsa-miR-29a hsa-miR-192 hsa-miR-449a hsa-miR-4275 hsa-miR-1273d hsa-miR-890 hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP36

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum2
    extracellular2
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARHGAP36           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP36 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with ARHGAP36           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP36
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP36
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP36

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ARHGAP36 (ENSP000002762114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF28ENSP000002967944STRING: ENSP00000296794
    ARHGEF3ENSP000003410714STRING: ENSP00000341071
    ITSN1ENSP000003707194STRING: ENSP00000370719
    ITSN2ENSP000003472444STRING: ENSP00000347244
    NET1ENSP000003471344STRING: ENSP00000347134
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP36           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP36 (RHG36)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP36 gene (2 alternative transcripts): 
    NM_001282607.1  NM_144967.3  

    Unigene Cluster for ARHGAP36:

    Rho GTPase activating protein 36
    Hs.22905  [show with all ESTs]
    Unigene Representative Sequence: NM_144967
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276211(uc004evz.3 uc004ewa.3) ENST00000370922 ENST00000423277
    ENST00000412432(uc004ewb.3) ENST00000370921(uc004ewc.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP36 (see all 41):
    hsa-miR-19b-2* hsa-miR-29a hsa-miR-192 hsa-miR-449a hsa-miR-4275 hsa-miR-1273d hsa-miR-890 hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ARHGAP36 (NM_144967)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP36
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP36
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP36

    Additional mRNA sequence: 

    AK054620.1 AK128203.1 AK294274.1 AK296748.1 BC063790.1 

    4 DOTS entries:

    DT.310874  DT.99971982  DT.310875  DT.95239492 

    Selected AceView cDNA sequences (see all 46):

    NM_144967 CR619310 CR625224 CD105854 Z39736 AK054620 AK128203 CD107189 
    CD107623 BQ716809 AI082418 CD106354 BX354250 BX417569 BX106992 BE162978 
    CD237772 BX354249 CD637237 BG716877 R44947 AL521293 Z43680 AL521294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP36 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -     -           -     -     -           -                                                                     
    SP2:                                -     -     -           -                                                                     
    SP3:                                            -           -                                                                     
    SP4:                                                        -                                                                     
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ARHGAP36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGGTAAC
    ARHGAP36 Expression
    About this image


    ARHGAP36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Adrenal Gland (Endocrine System)
    ARHGAP36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22905
        Custom PCR Arrays for ARHGAP36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP36 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap361 , 5 Rho GTPase activating protein 361, 5 85.13(n)1
    82.12(a)1
      X (25.95 cM)5
    754041  NM_001081123.11  NP_001074592.11 
     494639455 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    37(a)
    many ↔ many
    4(9488938-9502477)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1367636
    zgc:136763
    25(a)
    many ↔ many
    7(52819637-52916487) ENSDARG00000059672
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP102A6
    RhoGAP102A
    11(a)
    1 → many
    4(276143-285701)
    worm
    (Caenorhabditis elegans)
    Secernentea rga-66
    Protein RGA-6, isoform a (rga-6) mRNA, complete cd...
    13(a)
    1 → many
    I(4850682-4867825) WBGene00015303
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LRG16
    Putative GTPase-activating protein (GAP) involved ...
    9(a)
    1 → many
    IV(22823-25876) YDL240W


    ENSEMBL Gene Tree for ARHGAP36 (if available)
    TreeFam Gene Tree for ARHGAP36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP36 gene
    STARD132  ARHGAP62  ARHGAP402  ARHGAP182  DLC12  ARHGAP11A2  ARHGAP282  ARHGAP11B2  
    STARD82  
    1 SIMAP similar gene for ARHGAP36 using alignment to 2 protein entries:     RHG36_HUMAN (see all proteins):
    ARHGAP6

    Find genes that share paralogs with ARHGAP36           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP36 (see all 507)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911207431,2
    --130190370(+) GTTTCC/TGAGGA 1 -- us2k10--------
    rs626012831,2
    C,F--130190372(+) TTCCGT/AGGACT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs2008967001,2
    --130190443(+) GTTGG-/AAAAAA 1 -- us2k10--------
    rs351825721,2
    C,F--130190590(+) TATTCA/GTAAAG 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1810111501,2
    --130190617(+) AGCAGA/GTCTGG 1 -- us2k10--------
    rs1463852721,2
    --130190834(+) GCATTA/TATACT 1 -- us2k10--------
    rs1394180121,2
    --130190841(+) TACTAA/GTATCA 1 -- us2k10--------
    rs760212351,2
    C,F--130191183(+) GGGCTG/CTTTTT 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1860172371,2
    --130191200(+) ACCAGA/GGGCCC 1 -- us2k10--------
    rs1908723171,2
    --130191274(+) ATAAAA/GGAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP36 (130192216 - 130223857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARHGAP36:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523130CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP36
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP36 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARHGAP36)
        Utopia: connect your pdf to the dynamic
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    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158763 HGNC: 26388 AceView: FLJ30058 Ensembl:ENSG00000147256 euGenes: HUgn158763
    ECgene: ARHGAP36 H-InvDB: ARHGAP36

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP36 gene:
    Search GeneIP for patents involving ARHGAP36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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