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Aliases for ARHGAP36 Gene

Aliases for ARHGAP36 Gene

  • Rho GTPase Activating Protein 36 2 3

External Ids for ARHGAP36 Gene

Previous GeneCards Identifiers for ARHGAP36 Gene

  • GC0XP130192
  • GC0XP119585

Summaries for ARHGAP36 Gene

GeneCards Summary for ARHGAP36 Gene

ARHGAP36 (Rho GTPase Activating Protein 36) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP36 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP36 Gene

Genomics for ARHGAP36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP36 Gene

Start:
131,058,242 bp from pter
End:
131,089,885 bp from pter
Size:
31,644 bases
Orientation:
Plus strand

Genomic View for ARHGAP36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP36 Gene

No data available for Regulatory Elements for ARHGAP36 Gene

Proteins for ARHGAP36 Gene

  • Protein details for ARHGAP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRI8-RHG36_HUMAN
    Recommended name:
    Rho GTPase-activating protein 36
    Protein Accession:
    Q6ZRI8
    Secondary Accessions:
    • B7Z234
    • B7Z439
    • Q5JRL9
    • Q5JRM0
    • Q5JRM1
    • Q96NU6

    Protein attributes for ARHGAP36 Gene

    Size:
    547 amino acids
    Molecular mass:
    61664 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH63790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI41400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP36 Gene

Proteomics data for ARHGAP36 Gene at MOPED

Post-translational modifications for ARHGAP36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP36 Gene

No data available for DME Specific Peptides for ARHGAP36 Gene

Domains for ARHGAP36 Gene

Gene Families for ARHGAP36 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP36 Gene

Suggested Antigen Peptide Sequences for ARHGAP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZRI8

UniProtKB/Swiss-Prot:

RHG36_HUMAN :
  • Q6ZRI8
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP36: view

Function for ARHGAP36 Gene

Molecular function for ARHGAP36 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP36: view

Phenotypes for ARHGAP36 Gene

GenomeRNAi human phenotypes for ARHGAP36:
genes like me logo Genes that share phenotypes with ARHGAP36: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP36 Gene

miRTarBase miRNAs that target ARHGAP36

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP36

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP36 Gene

Localization for ARHGAP36 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP36 Gene COMPARTMENTS Subcellular localization image for ARHGAP36 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Pathways for ARHGAP36 Gene

genes like me logo Genes that share pathways with ARHGAP36: view

Pathways by source for ARHGAP36 Gene

3 Reactome pathways for ARHGAP36 Gene

Interacting Proteins for ARHGAP36 Gene

Gene Ontology (GO) - Biological Process for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

Transcripts for ARHGAP36 Gene

Unigene Clusters for ARHGAP36 Gene

Rho GTPase activating protein 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP36

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP36 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for ARHGAP36 Gene

GeneLoc Exon Structure for
ARHGAP36
ECgene alternative splicing isoforms for
ARHGAP36

Expression for ARHGAP36 Gene

mRNA expression in normal human tissues for ARHGAP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP36 Gene

This gene is overexpressed in Pituitary (31.0) and Brain - Hypothalamus (13.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGAP36 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP36 Gene Hs.22905

genes like me logo Genes that share expressions with ARHGAP36: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP36 Gene

Orthologs for ARHGAP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP36 35
  • 99.7 (n)
  • 99.27 (a)
ARHGAP36 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP36 35
  • 89.16 (n)
  • 88.47 (a)
ARHGAP36 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP36 35
  • 92.08 (n)
  • 92.87 (a)
ARHGAP36 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap36 35
  • 85.13 (n)
  • 82.12 (a)
Arhgap36 16
Arhgap36 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 7 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Arhgap36 35
  • 83.79 (n)
  • 81.25 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136763 36
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP102A 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-6 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 9 (a)
OneToMany
Species with no ortholog for ARHGAP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP36 Gene

ENSEMBL:
Gene Tree for ARHGAP36 (if available)
TreeFam:
Gene Tree for ARHGAP36 (if available)

Paralogs for ARHGAP36 Gene

Selected SIMAP similar genes for ARHGAP36 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP36: view

Variants for ARHGAP36 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP36 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3788 -- 131,089,786(-) TAAAT(A/G)ATCAA utr-variant-3-prime
rs3810726 -- 131,089,319(-) GCTGC(A/G)TGGAC utr-variant-3-prime
rs3810727 -- 131,089,163(-) CCCAT(C/T)TGGGG utr-variant-3-prime
rs3859990 -- 131,088,480(+) TATTC(A/T)TATAT intron-variant
rs3859991 -- 131,088,561(-) CAAGG(C/T)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP36 Gene

Variant ID Type Subtype PubMed ID
nsv523130 CNV Gain 19592680

Relevant External Links for ARHGAP36 Gene

HapMap Linkage Disequilibrium report
ARHGAP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Disorders for ARHGAP36 Gene

No disorders were found for ARHGAP36 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGAP36 Gene

Publications for ARHGAP36 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3

Products for ARHGAP36 Gene

  • antibodies-online peptides for ARHGAP36
  • antibodies-online antibodies for ARHGAP36
  • antibodies-online kits for ARHGAP36

Sources for ARHGAP36 Gene

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