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Aliases for ARHGAP36 Gene

Aliases for ARHGAP36 Gene

  • Rho GTPase Activating Protein 36 2 3 5

External Ids for ARHGAP36 Gene

Previous GeneCards Identifiers for ARHGAP36 Gene

  • GC0XP130192
  • GC0XP119585

Summaries for ARHGAP36 Gene

GeneCards Summary for ARHGAP36 Gene

ARHGAP36 (Rho GTPase Activating Protein 36) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP6.

UniProtKB/Swiss-Prot for ARHGAP36 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP36 Gene

Genomics for ARHGAP36 Gene

Regulatory Elements for ARHGAP36 Gene

Enhancers for ARHGAP36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARHGAP36 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP36 Gene

Chromosome:
X
Start:
131,056,486 bp from pter
End:
131,089,885 bp from pter
Size:
33,400 bases
Orientation:
Plus strand

Genomic View for ARHGAP36 Gene

Genes around ARHGAP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP36 Gene

Proteins for ARHGAP36 Gene

  • Protein details for ARHGAP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRI8-RHG36_HUMAN
    Recommended name:
    Rho GTPase-activating protein 36
    Protein Accession:
    Q6ZRI8
    Secondary Accessions:
    • B7Z234
    • B7Z439
    • Q5JRL9
    • Q5JRM0
    • Q5JRM1
    • Q96NU6

    Protein attributes for ARHGAP36 Gene

    Size:
    547 amino acids
    Molecular mass:
    61664 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH63790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI41400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP36 Gene

Post-translational modifications for ARHGAP36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP36 Gene

No data available for DME Specific Peptides for ARHGAP36 Gene

Domains & Families for ARHGAP36 Gene

Gene Families for ARHGAP36 Gene

Protein Domains for ARHGAP36 Gene

Suggested Antigen Peptide Sequences for ARHGAP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZRI8

UniProtKB/Swiss-Prot:

RHG36_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP36: view

Function for ARHGAP36 Gene

Molecular function for ARHGAP36 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view
genes like me logo Genes that share phenotypes with ARHGAP36: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP36 Gene

miRTarBase miRNAs that target ARHGAP36

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP36 Gene

Localization for ARHGAP36 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP36 Gene COMPARTMENTS Subcellular localization image for ARHGAP36 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Pathways & Interactions for ARHGAP36 Gene

genes like me logo Genes that share pathways with ARHGAP36: view

Pathways by source for ARHGAP36 Gene

3 Reactome pathways for ARHGAP36 Gene

Gene Ontology (GO) - Biological Process for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

No data available for SIGNOR curated interactions for ARHGAP36 Gene

Drugs & Compounds for ARHGAP36 Gene

No Compound Related Data Available

Transcripts for ARHGAP36 Gene

Unigene Clusters for ARHGAP36 Gene

Rho GTPase activating protein 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP36 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for ARHGAP36 Gene

GeneLoc Exon Structure for
ARHGAP36
ECgene alternative splicing isoforms for
ARHGAP36

Expression for ARHGAP36 Gene

mRNA expression in normal human tissues for ARHGAP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP36 Gene

This gene is overexpressed in Pituitary (x31.0) and Brain - Hypothalamus (x13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGAP36 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARHGAP36 Gene:

ARHGAP36

SOURCE GeneReport for Unigene cluster for ARHGAP36 Gene:

Hs.22905
genes like me logo Genes that share expression patterns with ARHGAP36: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARHGAP36 Gene

Orthologs for ARHGAP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP36 34
  • 89.16 (n)
  • 88.47 (a)
ARHGAP36 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP36 34
  • 92.08 (n)
  • 92.87 (a)
ARHGAP36 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap36 34
  • 85.13 (n)
  • 82.12 (a)
Arhgap36 16
Arhgap36 35
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP36 34
  • 99.7 (n)
  • 99.27 (a)
ARHGAP36 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap36 34
  • 83.79 (n)
  • 81.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 7 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136763 35
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP102A 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-6 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 35
  • 9 (a)
OneToMany
Species where no ortholog for ARHGAP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP36 Gene

ENSEMBL:
Gene Tree for ARHGAP36 (if available)
TreeFam:
Gene Tree for ARHGAP36 (if available)

Paralogs for ARHGAP36 Gene

(1) SIMAP similar genes for ARHGAP36 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP36: view

Variants for ARHGAP36 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP36 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747694795 -- 131,088,597(+) GAAAC(A/G)TAAGG intron-variant
rs747747908 -- 131,083,854(+) GGCTG(A/C)GGGCC reference, missense
rs747749800 -- 131,088,721(+) AGACC(A/G)CCCAT reference, missense
rs747821860 -- 131,061,336(+) GACAA(C/T)GGGCA intron-variant
rs747927127 -- 131,062,470(+) GATCC(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP36 Gene

Variant ID Type Subtype PubMed ID
nsv523130 CNV gain 19592680

Variation tolerance for ARHGAP36 Gene

Residual Variation Intolerance Score: 8.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Disorders for ARHGAP36 Gene

Relevant External Links for ARHGAP36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP36

No disorders were found for ARHGAP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP36 Gene

Publications for ARHGAP36 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Arhgap36-dependent activation of Gli transcription factors. (PMID: 25024229) Rack P.G. … Chen J.K. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 65
  5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3 65

Products for ARHGAP36 Gene

Sources for ARHGAP36 Gene

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