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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGAP36 Gene

protein-coding GIFtS: 45
GCID: GC0XP130192

Rho GTPase activating protein 36

Search for ARHGAP36
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 36¹ ²
FLJ30058¹
Rho GTPase-Activating Protein 36²

External Ids:	HGNC: 26388¹	Entrez Gene: 158763²	Ensembl: ENSG00000147256⁷	UniProtKB: Q6ZRI8³

Export aliases for ARHGAP36 gene to outside databases

Previous GC identifer: GC0XP119585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ARHGAP36
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ARHGAP36

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP36

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq26.1

ARHGAP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP36 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP130192: view genomic region (about GC identifiers)

Start:	130,192,216 bp from pter	End:	130,223,857 bp from pter
Size:	31,642 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 36 precursor

Size: 547 amino acids; 61664 Da

Sequence caution: Sequence=AAH63790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAI41400.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B7Z234 B7Z439 Q5JRL9 Q5JRM0 Q5JRM1 Q96NU6

Alternative splicing: 5 isoforms: Q6ZRI8-1 Q6ZRI8-2 Q6ZRI8-3 Q6ZRI8-4 Q6ZRI8-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP36: NX_Q6ZRI8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZRI8

ARHGAP36 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_659404.2

ENSEMBL proteins:

ENSP00000276211 ENSP00000359960 ENSP00000409218 ENSP00000408515 ENSP00000359959

Reactome Protein details: Q6ZRI8
Human Recombinant Protein Products for ARHGAP36:

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ARHGAP36 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP36 for domains About GeneDecksing

2 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q6ZRI8

ProtoNet protein and cluster: Q6ZRI8

1 Blocks protein family: IPB000198 RhoGAP domain

UniProtKB/Swiss-Prot: RHG36_HUMAN, Q6ZRI8

Similarity: Contains 1 Rho-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHG36_HUMAN, Q6ZRI8

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--

ARHGAP36 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ARHGAP36:

Synthetic lethal with Ras

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ARHGAP36

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

ARHGAP36 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP36

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

ARHGAP36 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ARHGAP36 gene:

NM_144967.3

Unigene Cluster for ARHGAP36:

Rho GTPase activating protein 36

Hs.22905 [show with all ESTs]

Unigene Representative Sequence: NM_144967

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000276211(uc004evz.3 uc004ewa.3) ENST00000370922 ENST00000423277

ENST00000412432(uc004ewb.3) ENST00000370921(uc004ewc.3)

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		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP36 (see all 41):
		hsa-miR-19b-2* hsa-miR-29a hsa-miR-192 hsa-miR-449a hsa-miR-4275 hsa-miR-1273d hsa-miR-890 hsa-miR-3148

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Additional cDNA sequence:

AK054620.1 AK128203.1 AK294274.1 AK296748.1 BC063790.1

4 DOTS entries:

DT.310874 DT.99971982 DT.310875 DT.95239492

24/46 AceView cDNA sequences (see all 46):

AK054620 NM_144967 CD106354 BQ716809 AK128203 CD105854 CD107623 CR619310

AI082418 CR625224 Z39736 BX354250 CD107189 BX417569 BE162978 AL521293

CD106159 CD637237 BX106992 BX354249 AL521294 Z43680 AA405456 R44947

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP36 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15
SP1:					-		-				-		-		-				-
SP2:											-		-		-				-
SP3:															-				-
SP4:																			-
SP5:

ECgene alternative splicing isoforms for ARHGAP36

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGAP36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGGTAAC

About this image

ARHGAP36 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARHGAP36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP36

SOURCE GeneReport for Unigene cluster: Hs.22905

SABiosciences Custom PCR Arrays for ARHGAP36

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP36 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARHGAP40⁶ ARHGAP36⁶	Uncharacterized protein	7(a) 28(a)	possible ortholog 1 ↔ 1	Un(6089373-6095158) 4(9586935-9598446)
zebrafish (Danio rerio)	Actinopterygii	zgc:136763⁶	zgc:136763	18(a)	1 ↔ 1	7(52819637-52916487)
fruit fly (Drosophila melanogaster)	Insecta	RhoGAP102A⁶	RhoGAP102A	7(a)	1 → many	4(276143-285701)
worm (Caenorhabditis elegans)	Secernentea	rga-6⁶	Protein RGA-6, isoform a	8(a)	1 → many	I(4850683-4867826)

ENSEMBL Gene Tree for ARHGAP36 (if available)
TreeFam Gene Tree for ARHGAP36 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGAP36 gene

ARHGAP6² STARD13² ARHGAP40² ARHGAP18² ARHGAP11A² DLC1² ARHGAP28² ARHGAP11B²

STARD8²

1 SIMAP similar gene for ARHGAP36 using alignment to 2 protein entries: RHG36_HUMAN (see all proteins):

ARHGAP6

ARHGAP36 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191120743^1,2		--	130190370(+)	`GTTTCC/TGAGGA`	1	--	us2k¹		0	--	--	--	--
rs62601283^1,2	C	--	130190372(+)	`TTCCGT/AGGACT`	1	--	us2k¹		1		NA	2
rs200896700^1,2		--	130190443(+)	`GTTGG-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs35182572^1,2	C	--	130190590(+)	`TATTCA/GTAAAG`	1	--	us2k¹		1		NA	2
rs181011150^1,2		--	130190617(+)	`AGCAGA/GTCTGG`	1	--	us2k¹		0	--	--	--	--
rs146385272^1,2		--	130190834(+)	`GCATTA/TATACT`	1	--	us2k¹		0	--	--	--	--
rs139418012^1,2		--	130190841(+)	`TACTAA/GTATCA`	1	--	us2k¹		0	--	--	--	--
rs76021235^1,2	C	--	130191183(+)	`GGGCTG/CTTTTT`	1	--	us2k¹		2		NA	4
rs186017237^1,2		--	130191200(+)	`ACCAGA/GGGCCC`	1	--	us2k¹		0	--	--	--	--
rs190872317^1,2		--	130191274(+)	`ATAAAA/GGAAGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARHGAP36 (130192216 - 130223857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGAP36: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARHGAP36 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGAP36)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 158763	HGNC: 26388	AceView: FLJ30058	Ensembl:ENSG00000147256	euGenes: HUgn158763
ECgene: ARHGAP36	H-InvDB: ARHGAP36

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARHGAP36	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARHGAP36 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARHGAP36 gene:
Search GeneIP for patents involving ARHGAP36

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for ARHGAP36
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP36		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP36
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP36
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	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP36		GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP36
	GenScript Custom Assay Services for ARHGAP36		GenScript Custom Superior Antibodies Services for ARHGAP36
	GenScript Custom overexpressing Cell Line Services for ARHGAP36		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP36

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARHGAP36

Sirion Biotech Customized:

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	stable overexpressing cell line services for ARHGAP36
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARHGAP36 gene at Home site.

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ARHGAP36 Gene

Rho GTPase activating protein 36

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ARHGAP36 Gene

Rho GTPase activating protein 36

Aliasesfor ARHGAP36 gene

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for ARHGAP36 gene

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for ARHGAP36 gene

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