Aliases for ARHGAP35 Gene
External Ids for ARHGAP35 Gene
Previous HGNC Symbols for ARHGAP35 Gene
Previous GeneCards Identifiers for ARHGAP35 Gene
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGAP35 Gene
ARHGAP35 (Rho GTPase Activating Protein 35) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and Focal Adhesion. GO annotations related to this gene include GTP binding and transcription corepressor activity. An important paralog of this gene is ARHGAP5.
UniProtKB/Swiss-Prot for ARHGAP35 Gene
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5-GAGAAAAGAAACTGGAGAAACTC-3 (PubMed:1894621). May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Modulates Rho GTPase-dependent F-actin polymerization and is involved in the positive regulation of ciliogenesis and cilia elongation (By similarity).