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ARHGAP35 Gene

protein-coding   GIFtS: 52
GCID: GC19P047422

Rho GTPase Activating Protein 35

(Previous name: glucocorticoid receptor DNA binding factor 1)
(Previous symbol: GRLF1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 351 2     P190-A2
GRLF11 2 3 5     p190ARhoGAP2
Glucocorticoid Receptor DNA Binding Factor 11 2     p190RhoGAP2
Glucocorticoid Receptor DNA-Binding Factor 12 3     Rho GTPase-Activating Protein 352
Glucocorticoid Receptor Repression Factor 12 3     GRF13
Rho GAP P190A2 3     KIAA17223
GRF-12 3     p190-A3
P190A2 5     

External Ids:    HGNC: 45911   Entrez Gene: 29092   Ensembl: ENSG000001600077   OMIM: 6052775   UniProtKB: Q9NRY43   

Export aliases for ARHGAP35 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP35 Gene:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the
glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid
sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc
finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The
GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests
that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its
interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ARHGAP35 Gene:
ARHGAP35 (Rho GTPase activating protein 35) is a protein-coding gene. GO annotations related to this gene include Rho GTPase activator activity and GTP binding. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG35_HUMAN, Q9NRY4
Function: Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence
5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May
transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act
as a tumor suppressor

Gene Wiki entry for ARHGAP35 (GRLF1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGAP35
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ARHGAP35 promoter sequence
   Search Chromatin IP Primers for ARHGAP35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

ARHGAP35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP35 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P047422:  view genomic region     (about GC identifiers)

Start:
47,421,933 bp from pter      End:
47,508,334 bp from pter
Size:
86,402 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG35_HUMAN, Q9NRY4 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 35  
Size: 1499 amino acids; 170514 Da
Subunit: Interacts with RASA1. Interacts with the general transcription factor GTF2I, the interaction sequesters
GTF2I in the cytoplasm
Sequence caution: Sequence=AAA58618.1; Type=Frameshift; Positions=389, 533, 540, 607, 614, 1167, 1241, 1292, 1334,
1446; Sequence=AAF80386.1; Type=Frameshift; Positions=533, 540, 607, 614; Sequence=AAF80386.1; Type=Miscellaneous
discrepancy; Note=Unlikely isoform. Aberrant splice sites;
3 PDB 3D structures from and Proteopedia for ARHGAP35:
2K85 (3D)        3C5H (3D)        3FK2 (3D)    
Secondary accessions: A7E2A4 Q14452 Q9C0E1

Explore the universe of human proteins at neXtProt for ARHGAP35: NX_Q9NRY4

Explore proteomics data for ARHGAP35 at MOPED

Post-translational modifications: 

  • Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS.
    Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004482.4  
    ENSEMBL proteins: 
     ENSP00000385720  
    Reactome Protein details: Q9NRY4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR002713 FF_domain
     IPR008936 Rho_GTPase_activation_prot
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRY4

    ProtoNet protein and cluster: Q9NRY4

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB002713 FF domain


    UniProtKB/Swiss-Prot: RHG35_HUMAN, Q9NRY4
    Similarity: Contains 4 FF domains
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG35_HUMAN, Q9NRY4
    Function: Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence
    5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May
    transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act
    as a tumor suppressor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS1894621
    GO:0005100Rho GTPase activator activity TAS--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with ARHGAP35           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Grlf1):
     embryogenesis  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 
     pigmentation  renal/urinary system  vision/eye 

    Find genes that share phenotypes with ARHGAP35           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ARHGAP35: Grlf1tm2Jset Grlf1tm1Jset

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP35
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    miRNA
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    hsa-mir-181b-5p (MIRT047266), hsa-mir-296-3p (MIRT038489)

    Block miRNA regulation of human, mouse, rat ARHGAP35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP35 (see all 74):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP35 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP35

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    Addgene plasmids for ARHGAP35 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG35_HUMAN, Q9NRY4: Cytoplasm (By similarity). Nucleus (By similarity)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IC1894621
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton IEA--

    Find genes that share ontologies with ARHGAP35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP35 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Sema4D mediated inhibition of cell attachment and migration0.00
    Semaphorin interactions0.43
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    5Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32


    Find genes that share SuperPaths with ARHGAP35           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ARHGAP35
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for ARHGAP35
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility

    4 BioSystems Pathways for ARHGAP35
        Regulation of Actin Cytoskeleton
    EPHA2 forward signaling
    Regulation of RhoA activity
    Signaling events mediated by focal adhesion kinase

    2 Reactome Pathways for ARHGAP35
        Sema4D mediated inhibition of cell attachment and migration
    Rho GTPase cycle


    3 Kegg Pathways  (Kegg details for ARHGAP35):
        Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP35
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP35 (Q9NRY43 ENSP000003857204) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    MYL12BO149503, ENSP000002375004I2D: score=1 STRING: ENSP00000237500
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with ARHGAP35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP35 (RHG35)

    1 Novoseek inferred chemical compound relationship for ARHGAP35 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.8 14 11342655 (3), 9417037 (1), 12606561 (1), 10873807 (1) (see all 6)



    Find genes that share compounds with ARHGAP35           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP35 gene (2 alternative transcripts): 
    NM_004491.4  NM_024342.1  

    Unigene Cluster for ARHGAP35:

    Rho GTPase activating protein 35
    Hs.509447  [show with all ESTs]
    Unigene Representative Sequence: NM_004491
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404338(uc010ekv.3) ENST00000595822 ENST00000596593 ENST00000598548
    ENST00000599284
    miRNA
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    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-3142 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP35 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP35

    Additional mRNA sequence: 

    AB051509.2 AF159851.1 AK097314.1 AK298356.1 AL831914.1 BC003514.1 BC065491.1 BC131565.1 
    BC150257.1 M73077.1 

    16 DOTS entries:

    DT.95093068  DT.114872  DT.95082732  DT.100030124  DT.99943524  DT.100813182  DT.100813179  DT.95093048 
    DT.95093069  DT.100813180  DT.102830952  DT.121504799  DT.95093082  DT.95312478  DT.121504741  DT.121504840 

    Selected AceView cDNA sequences (see all 389):

    CA398198 BF445994 BI827118 AA746046 BF447396 BE728172 CA423691 BU166645 
    AW504664 AI432337 AI017823 BM843486 BU619931 BF876061 CB124499 BF445691 
    BE206969 AI016657 AW151743 AL040711 W02701 BM969153 BQ430852 BM680476 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP35    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                                -     -     -           -               
    SP2:                                -     -     -           -               
    SP3:                                            -           -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for ARHGAP35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTGCTAC
    ARHGAP35 Expression
    About this image

    ARHGAP35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509447
        Custom PCR Arrays for ARHGAP35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP35 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grlf11 , 5 glucocorticoid receptor DNA binding factor 11, 5 89.72(n)1
    97.86(a)1
      7 (9.15 cM)5
    2329061  NM_172739.41  NP_766327.31 
     164944735 
    chicken
    (Gallus gallus)
    Aves ARHGAP351 Rho GTPase activating protein 35 73.1(n)
    82.94(a)
      425730  XM_003643760.2  XP_003643808.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP356
    Rho GTPase activating protein 35
    92(a)
    1 ↔ 1
    GL343566.1(191675-263864)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL774029.22   -- 75.2(n)    AL774029.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BM184827.12   -- 74.48(n)    BM184827.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1901 RhoGAPp190 48.47(n)
    37.78(a)
      32743  NM_001272729.1  NP_001259658.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rga-56
    Protein RGA-5, isoform a (rga-5) mRNA, complete cd...
    26(a)
    1 → many
    IV(13827886-13844978) WBGene00010374


    ENSEMBL Gene Tree for ARHGAP35 (if available)
    TreeFam Gene Tree for ARHGAP35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP35 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP442  SH3BP12  
    ARHGAP252  SRGAP22  ARHGAP42  
    5 SIMAP similar genes for ARHGAP35 using alignment to 1 protein entry:     RHG35_HUMAN:
    GRLF1    ARHGAP5    CHN1    ARHGAP12    ARHGAP9

    Find genes that share paralogs with ARHGAP35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP35 (see all 1719)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827596271,2
    --47419951(+) ACAAAA/GGAATA 1 -- us2k10--------
    rs356360801,2
    C--47419985(+) ATCTA-/TTTTTT 1 -- us2k10--------
    rs1878353691,2
    --47420026(+) ACCACA/CCCATT 1 -- us2k10--------
    rs1913176811,2
    --47420054(+) TGTATA/TCATAA 1 -- us2k10--------
    rs1831795521,2
    --47420075(+) GGGATC/GAGTTA 1 -- us2k10--------
    rs1502861901,2
    --47420120(+) GTGTCA/GGTTTC 1 -- us2k10--------
    rs1379836231,2
    --47420171(+) TTACAC/TTGATA 1 -- us2k10--------
    rs81126941,2
    C,F,A,H--47420290(+) tttaaC/Atatac 1 -- us2k1 tfbs38Minor allele frequency- A:0.08NS NA WA 1012
    rs1870630751,2
    --47420390(+) AGTAAC/TTTTTC 1 -- us2k10--------
    rs1922177771,2
    --47420667(+) TGAAAA/CCAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP35 (47421933 - 47508334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGAP35:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33665CNV Loss17666407
    nsv912192CNV Loss21882294
    esv2750638CNV Gain17666407
    nsv520664CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP35
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605277    OMIM disorders: --


    Find genes that share disorders with ARHGAP35           About GenesLikeMe

    2 Novoseek inferred disease relationships for ARHGAP35 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 14.4 3 12600941 (2), 11054565 (1)
    tumors 0 5 11054565 (3), 12600941 (1)


    Export disorders for ARHGAP35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP35 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with ARHGAP35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. (PubMed id 1894621)1, 2, 3, 9 LeClerc S.... Govindan M.V. (J. Biol. Chem. 1991)
    2. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. (PubMed id 11054565)1, 2, 9 Tikoo A....Maruta H. (Gene 2000)
    3. Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. (PubMed id 20675588)1, 3 NAcmeth T....MA^csai A. (J. Immunol. 2010)
    4. NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding. (PubMed id 19393245)1, 2 Bonet R.... Macias M.J. (J. Mol. Biol. 2009)
    5. Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. (PubMed id 18829532)1, 2 Shen C.H.... Chen R.H. (Cancer Res. 2008)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. (PubMed id 19435801)1, 9 Tomar A....Schlaepfer D.D. (J. Cell. Sci. 2009)
    10. Opposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis. (PubMed id 18642445)1, 9 Mikawa M....Parsons S.J. (Cell Cycle 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2909 HGNC: 4591 AceView: GRLF1 Ensembl:ENSG00000160007 euGenes: HUgn2909
    ECgene: ARHGAP35 Kegg: 2909 H-InvDB: ARHGAP35

    (According to HUGE)
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    HUGE: KIAA1722

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP35 gene:
    Search GeneIP for patents involving ARHGAP35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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