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Aliases for ARHGAP33 Gene

Aliases for ARHGAP33 Gene

  • Rho GTPase Activating Protein 33 2 3
  • TCGAP 3 4 6
  • Rho-Type GTPase-Activating Protein 33 3 4
  • Tc10/CDC42 GTPase-Activating Protein 3 4
  • Sorting Nexin 26 2 3
  • Sorting Nexin-26 3 4
  • SNX26 3 4
  • Neurite Outgrowth Multiadaptor RhoGAP Protein 3
  • Rho GTPase-Activating Protein 33 3
  • NOMA-GAP 3

External Ids for ARHGAP33 Gene

Previous HGNC Symbols for ARHGAP33 Gene

  • SNX26

Previous GeneCards Identifiers for ARHGAP33 Gene

  • GC19P036266
  • GC19P032771

Summaries for ARHGAP33 Gene

Entrez Gene Summary for ARHGAP33 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for ARHGAP33 Gene

ARHGAP33 (Rho GTPase Activating Protein 33) is a Protein Coding gene. Diseases associated with ARHGAP33 include noma. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for ARHGAP33 Gene

  • May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Gene Wiki entry for ARHGAP33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP33 Gene

Genomics for ARHGAP33 Gene

Genomic Location for ARHGAP33 Gene

Start:
35,774,532 bp from pter
End:
35,788,822 bp from pter
Size:
14,291 bases
Orientation:
Plus strand

Genomic View for ARHGAP33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP33 Gene

No data available for Regulatory Elements for ARHGAP33 Gene

Proteins for ARHGAP33 Gene

  • Protein details for ARHGAP33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14559-RHG33_HUMAN
    Recommended name:
    Rho GTPase-activating protein 33
    Protein Accession:
    O14559
    Secondary Accessions:
    • O14552
    • O14560
    • Q6ZSP6
    • Q96CP3
    • Q9NT23

    Protein attributes for ARHGAP33 Gene

    Size:
    1287 amino acids
    Molecular mass:
    137213 Da
    Quaternary structure:
    • Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6.
    SequenceCaution:
    • Sequence=AAB81198.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP33 Gene

Proteomics data for ARHGAP33 Gene at MOPED

Post-translational modifications for ARHGAP33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP33 Gene

No data available for DME Specific Peptides for ARHGAP33 Gene

Domains for ARHGAP33 Gene

Gene Families for ARHGAP33 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP33 Gene

Suggested Antigen Peptide Sequences for ARHGAP33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14559

UniProtKB/Swiss-Prot:

RHG33_HUMAN :
  • O14559
Domain:
  • Belongs to the PX domain-containing GAP family.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP33: view

Function for ARHGAP33 Gene

Molecular function for ARHGAP33 Gene

UniProtKB/Swiss-Prot Function: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 16777849
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ARHGAP33: view

Phenotypes for ARHGAP33 Gene

MGI mutant phenotypes for ARHGAP33:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ARHGAP33: view

miRNA for ARHGAP33 Gene

miRTarBase miRNAs that target ARHGAP33

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP33 Gene

Localization for ARHGAP33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP33 Gene COMPARTMENTS Subcellular localization image for ARHGAP33 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP33: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP33 Gene

Pathways for ARHGAP33 Gene

genes like me logo Genes that share pathways with ARHGAP33: view

Pathways by source for ARHGAP33 Gene

1 BioSystems pathway for ARHGAP33 Gene
3 Reactome pathways for ARHGAP33 Gene

Gene Ontology (GO) - Biological Process for ARHGAP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP33: view

Transcripts for ARHGAP33 Gene

Unigene Clusters for ARHGAP33 Gene

Rho GTPase activating protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP33 Gene

GeneLoc Exon Structure for
ARHGAP33
ECgene alternative splicing isoforms for
ARHGAP33

Expression for ARHGAP33 Gene

mRNA expression in normal human tissues for ARHGAP33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGAP33 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP33 Gene Hs.515364

genes like me logo Genes that share expressions with ARHGAP33: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP33 Gene

Orthologs for ARHGAP33 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP33 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP33 35
  • 89.1 (n)
  • 93.24 (a)
ARHGAP33 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
ARHGAP33 35
  • 89.21 (n)
  • 93.73 (a)
mouse
(Mus musculus)
Mammalia Arhgap33 35
  • 86.28 (n)
  • 92.14 (a)
Arhgap33 16
Arhgap33 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP33 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP33 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap33 35
  • 84.5 (n)
  • 89.42 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARHGAP33 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgap33 36
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 36
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ARHGAP33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP33 Gene

ENSEMBL:
Gene Tree for ARHGAP33 (if available)
TreeFam:
Gene Tree for ARHGAP33 (if available)

Paralogs for ARHGAP33 Gene

Paralogs for ARHGAP33 Gene

Selected SIMAP similar genes for ARHGAP33 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP33 Gene

genes like me logo Genes that share paralogs with ARHGAP33: view

Variants for ARHGAP33 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP33 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs120959 -- 35,785,501(+) GGCAA(G/T)TGGGG intron-variant
rs120960 -- 35,785,865(+) TTTCC(A/G)GGTCT intron-variant
rs179569 -- 35,780,709(+) CCTGC(A/G)TCTTT intron-variant
rs231222 -- 35,783,586(+) ggagc(C/T)gcagg intron-variant, upstream-variant-2KB
rs231223 -- 35,782,328(+) GCGAG(C/G)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP33 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv911636 CNV Loss 21882294
nsv911637 CNV Loss 21882294
nsv911638 CNV Loss 21882294

Relevant External Links for ARHGAP33 Gene

HapMap Linkage Disequilibrium report
ARHGAP33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP33 Gene

Disorders for ARHGAP33 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARHGAP33 Gene including...

Search for ARHGAP33 Gene in MalaCards »

Relevant External Links for ARHGAP33

Human Genome Epidemiology (HuGE) Navigator
ARHGAP33
genes like me logo Genes that share disorders with ARHGAP33: view

No data available for UniProtKB/Swiss-Prot for ARHGAP33 Gene

Publications for ARHGAP33 Gene

  1. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. (PMID: 12297274) Peck J. … Burbelo P.D. (FEBS Lett. 2002) 2 3
  2. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby C.A. … Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARHGAP33 Gene

  • antibodies-online peptides for ARHGAP33
  • antibodies-online antibodies for ARHGAP33
  • antibodies-online kits for ARHGAP33

Sources for ARHGAP33 Gene

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