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ARHGAP33 Gene

protein-coding   GIFtS: 50
GCID: GC19P036266

Rho GTPase Activating Protein 33

(Previous name: sorting nexin 26)
(Previous symbol: SNX26)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 331 2     Sorting Nexin-262 3
SNX261 2 3     Tc10/CDC42 GTPase-Activating Protein2 3
TCGAP2 3 5     NOMA-GAP2
Sorting Nexin 261 2     Neurite Outgrowth Multiadaptor RhoGAP Protein2
Rho-Type GTPase-Activating Protein 332 3     Rho GTPase-Activating Protein 332

External Ids:    HGNC: 230851   Entrez Gene: 1157032   Ensembl: ENSG000000047777   OMIM: 6149025   UniProtKB: O145593   

Export aliases for ARHGAP33 gene to outside databases

Previous GC identifer: GC19P032771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP33 Gene:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which
is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants
encoding different isoforms have been identified in this gene. (provided by RefSeq, Feb 2010)

GeneCards Summary for ARHGAP33 Gene:
ARHGAP33 (Rho GTPase activating protein 33) is a protein-coding gene. Diseases associated with ARHGAP33 include noma, and endometriosis. GO annotations related to this gene include Rac GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP30.

UniProtKB/Swiss-Prot: RHG33_HUMAN, O14559
Function: May be involved in several stages of intracellular trafficking. Could play an important role in the
regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of
insulin-stimulated glucose transport (By similarity)

Gene Wiki entry for ARHGAP33 (SNX26) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGAP33
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP33 promoter sequence
   Search Chromatin IP Primers for ARHGAP33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ARHGAP33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP33 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036266:  view genomic region     (about GC identifiers)

Start:
36,265,434 bp from pter      End:
36,279,724 bp from pter
Size:
14,291 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHG33_HUMAN, O14559 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 33  
Size: 1287 amino acids; 137213 Da
Subunit: Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts
with NEK6
Sequence caution: Sequence=AAB81198.1; Type=Erroneous gene model prediction;
Secondary accessions: O14552 O14560 Q6ZSP6 Q96CP3 Q9NT23
Alternative splicing: 4 isoforms:  O14559-1   O14559-10   O14559-11   O14559-12   (Ref.2 (BAC86902) sequence differs from that shown due to several frameshifts)

Explore the universe of human proteins at neXtProt for ARHGAP33: NX_O14559

Explore proteomics data for ARHGAP33 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166101.1  NP_443180.2  

    ENSEMBL proteins: 
     ENSP00000368227   ENSP00000465411   ENSP00000320038   ENSP00000467844   ENSP00000466443  
     ENSP00000007510  
    Reactome Protein details: O14559

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001683 Phox
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O14559

    ProtoNet protein and cluster: O14559

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG33_HUMAN, O14559
    Similarity: Belongs to the PX domain-containing GAP family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    ARHGAP33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG33_HUMAN, O14559
    Function: May be involved in several stages of intracellular trafficking. Could play an important role in the
    regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of
    insulin-stimulated glucose transport (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity ----
    GO:0005515protein binding IPI16777849
    GO:0030675Rac GTPase activator activity IEA--
    GO:0035091phosphatidylinositol binding IEA--
         
    ARHGAP33 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgap33):
     nervous system 

    ARHGAP33 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP33
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    hsa-mir-193b-3p (MIRT041421)

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    hsa-miR-4254 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-664 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP33 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    ARHGAP33 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP33 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARHGAP33
        Insulin Signaling

    1 Reactome Pathway for ARHGAP33
        Rho GTPase cycle



    ARHGAP33 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP33
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP33 (O145591, 3 ENSP000003200384) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411, 3, ENSP000003576564EBI-1210010,EBI-515315 I2D: score=4 STRING: ENSP00000357656
    RAC1P630003, ENSP000003484614I2D: score=3 STRING: ENSP00000348461
    RHOJQ9H4E53, ENSP000003167294I2D: score=1 STRING: ENSP00000316729
    CDC42P609533I2D: score=1 
    YWHAEP622583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport IEA--
    GO:0032321positive regulation of Rho GTPase activity ----
    GO:0032855positive regulation of Rac GTPase activity ----

    ARHGAP33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP33 (RHG33)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGAP33 gene (2 alternative transcripts): 
    NM_001172630.1  NM_052948.3  

    Unigene Cluster for ARHGAP33:

    Rho GTPase activating protein 33
    Hs.515364  [show with all ESTs]
    Unigene Representative Sequence: NM_001172630
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589133 ENST00000378944(uc002obt.2) ENST00000590893 ENST00000314737(uc002obs.2)
    ENST00000221905(uc010eek.2) ENST00000601474 ENST00000588248 ENST00000591438
    ENST00000586918 ENST00000587447 ENST00000593034 ENST00000587984 ENST00000007510(uc002obr.2 uc002obv.1)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ARHGAP33:
    hsa-miR-4254 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-664 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP33 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP33

    Additional mRNA sequence: 

    AK096338.1 AK127255.1 AL137579.1 AY044864.1 BC014084.2 BC128586.1 

    8 DOTS entries:

    DT.436066  DT.406020  DT.100751306  DT.75190586  DT.121409149  DT.40109448  DT.406018  DT.91888560 

    Selected AceView cDNA sequences (see all 40):

    Z38468 CR625873 BC014084 AY044864 AK127255 NM_052948 CD557424 AL137579 
    BI524193 AI823348 BX431046 BX281283 AA299345 AL536431 AK096338 Z42222 
    BG913058 BX431652 BI523815 AI823347 AI369841 BG912541 BX420991 BI915639 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP33 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ARHGAP33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCACTAAA
    ARHGAP33 Expression
    About this image


    ARHGAP33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    ARHGAP33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515364
        Custom PCR Arrays for ARHGAP33
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP33 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap331 , 5 Rho GTPase activating protein 331, 5 86.28(n)1
    92.14(a)1
      7 (18.43 cM)5
    2330711  NM_178252.21  NP_839983.11 
     305222265 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    52(a)
    many ↔ many
    AADN03021558.1(379-1346)
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP336
    Rho GTPase activating protein 33
    48(a)
    1 ↔ 1
    GL343276.1(1378296-1431222)
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap336
    Rho GTPase activating protein 33
    26(a)
    many ↔ many
    16(47618766-47713483) ENSDARG00000011333
    fruit fly
    (Drosophila melanogaster)
    Insecta CdGAPr6
    CdGAPr
    17(a)
    1 → many
    2L(19774873-19791882)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGD16
    GTPase-activating protein (RhoGAP) for Rho3p and R...
    12(a)
    1 → many
    II(732639-734639) YBR260C


    ENSEMBL Gene Tree for ARHGAP33 (if available)
    TreeFam Gene Tree for ARHGAP33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP33 gene
    ARHGAP302  RALBP12  ARHGAP322  ARHGAP312  
    10 SIMAP similar genes for ARHGAP33 using alignment to 4 protein entries:     RHG33_HUMAN (see all proteins):
    SNX26    RICS    ARHGAP12    CHN1    DKFZp451F1115    ARHGAP32
    FAM13A    ARHGAP21    ARHGAP9    ARHGAP23

    ARHGAP33 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARHGAP33
    PGOHUM00000256835


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP33 (see all 427)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404453231,2
    Cuntested136275163(+) GCTCAC/TCCATG 4 T I mis11Minor allele frequency- T:0.00NA 4548
    rs1502116451,2
    --36264426(+) AGAAGC/GAATAT 2 -- us2k10--------
    rs106685851,2
    C--36264571(+) TAttt-/A/TTT 
            
    ttttt
    4 -- us2k1 cds1 trp30--------
    rs39334211,2
    C,F,A,H--36264642(+) tgactG/Acaacc 2 -- us2k13Minor allele frequency- A:0.33NA WA 6
    rs666385131,2
    C,F--36264651(+) CCTCCA/GCCTCC 2 -- us2k12Minor allele frequency- G:0.25NA 4
    rs8074821,2
    C,F,A--36264722(+) accacG/Acctgg 2 -- us2k17Minor allele frequency- A:0.46NA WA CSA 13
    rs8074831,2
    C,F,A--36264860(+) cactgC/Tcccca 2 -- us2k15Minor allele frequency- T:0.44NA WA CSA 9
    rs570248391,2
    C--36264895(+) TTTTT-/TT/TTT
            
    GAGAC
    4 -- us2k1 cds11NA 2
    rs8074841,2
    C,F,A,H--36264986(+) ccattG/Ctcttg 2 -- us2k17Minor allele frequency- C:0.48NA WA CSA 133
    rs1814041361,2
    --36265064(+) TTAGTA/GGAGAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP33 (36265434 - 36279724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ARHGAP33:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3853n71CNV Loss21882294
    dgv3852n71CNV Loss21882294
    nsv911636CNV Loss21882294
    nsv911638CNV Loss21882294
    nsv911637CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP33
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614902    OMIM disorders: --

    3 diseases for ARHGAP33:    
    About MalaCards
    noma    endometriosis    cerebritis


    ARHGAP33 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ARHGAP33 (0 documents)

    Export disorders for ARHGAP33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ARHGAP33 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ARHGAP33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. (PubMed id 12297274)1, 3 Peck J....Burbelo P.D. (FEBS Lett. 2002)
    6. Sorting out the cellular functions of sorting nexins. (PubMed id 12461558)1, 3 Worby C.A. and Dixon J.E. (Nat. Rev. Mol. Cell Biol. 2002)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    9. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    10. The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. (PubMed id 17664338)1 RosA!rio M....Birchmeier W. (J. Cell Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 115703 HGNC: 23085 AceView: SNX26 Ensembl:ENSG00000004777 euGenes: HUgn115703
    ECgene: ARHGAP33 H-InvDB: ARHGAP33

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARHGAP33 gene:
    Search GeneIP for patents involving ARHGAP33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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