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ARHGAP32 Gene

protein-coding   GIFtS: 58
GCID: GC11M128834

Rho GTPase Activating Protein 32

  See ARHGAP32-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 321 2     p200RhoGAP2 3
GRIT2 3 5     PX-RICS2
RICS2 3 5     Brain-Specific Rho GTP-Ase-Activating Protein2
p250GAP2 3 5     GAB-Associated CDC422
Brain-Specific Rho GTPase-Activating Protein2 3     GTPase-Activating Protein For Cdc42 And Rac12
Rho-Type GTPase-Activating Protein 322 3     Rac GTPase Activating Protein2
Rho/Cdc42/Rac GTPase-Activating Protein RICS2 3     Rho GTPase-Activating Protein 322
RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling2 3     RhoGAP Involved In The -Catenin-N-Cadherin And NMDA Receptor Signaling2
GC-GAP2 3     KIAA07123
GAB-Associated Cdc42/Rac GTPase-Activating Protein2 3     p200RHOGAP5
GTPase Regulator Interacting With TrkA2 3     

External Ids:    HGNC: 173991   Entrez Gene: 97432   Ensembl: ENSG000001349097   OMIM: 6085415   UniProtKB: A7KAX93   

Export aliases for ARHGAP32 gene to outside databases

Previous GC identifer: GC11M124785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP32 Gene:
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by
modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 (PubMed 12531901)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for ARHGAP32 Gene:
ARHGAP32 (Rho GTPase activating protein 32) is a protein-coding gene. Diseases associated with ARHGAP32 include schizotypal personality disorder. GO annotations related to this gene include phosphatidylinositol binding and GTPase activator activity. An important paralog of this gene is ARHGAP30.

UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
Function: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be
involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA
receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and
Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity)

Gene Wiki entry for ARHGAP32 (RICS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGAP32
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP32 promoter sequence
   Search Chromatin IP Primers for ARHGAP32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.3

ARHGAP32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128834:  view genomic region     (about GC identifiers)

Start:
128,834,955 bp from pter      End:
129,149,219 bp from pter
Size:
314,265 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 32  
Size: 2087 amino acids; 230529 Da
Subunit: Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation
state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is
necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with
GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1
may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex.
Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32.
Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the
interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity)
Sequence caution: Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ARHGAP32:
3IUG (3D)    
Secondary accessions: O94820 Q86YL6 Q8IUG4 Q9BWG3
Alternative splicing: 3 isoforms:  A7KAX9-1   A7KAX9-2   A7KAX9-3   

Explore the universe of human proteins at neXtProt for ARHGAP32: NX_A7KAX9

Explore proteomics data for ARHGAP32 at MOPED

Post-translational modifications: 

  • Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo
    dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the
    presence of calmodulin and calcium; which inhibits GAP activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136157.1  NP_055530.2  

    ENSEMBL proteins: 
     ENSP00000310561   ENSP00000376425   ENSP00000432468   ENSP00000432862   ENSP00000432303  
    Reactome Protein details: A7KAX9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001683 Phox
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry A7KAX9

    ProtoNet protein and cluster: A7KAX9

    UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
    Domain: The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)
    Similarity: Belongs to the PX domain-containing GAP family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ARHGAP32           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG32_HUMAN, A7KAX9
    Function: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be
    involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA
    receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and
    Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI12788081
    GO:0035091phosphatidylinositol binding IEA--
         
    Find genes that share ontologies with ARHGAP32           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP32:
     Decreased p24 protein expressi  Increased viability after born 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap32):
     cellular  nervous system  reproductive system 

    Find genes that share phenotypes with ARHGAP32           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgap32tm1Taki for ARHGAP32

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP32 (see all 52):
    hsa-miR-194* hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-503 hsa-miR-29b-1* hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP32 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG32_HUMAN, A7KAX9: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection,
    dendritic spine (By similarity). Cytoplasm, cell cortex. Endosome membrane (By similarity). Golgi apparatus
    membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Membrane. Note=Association to membrane
    via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic
    spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane
    upon EGF treatment. Colocalizes with GAB2 at the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane3
    endoplasmic reticulum2
    endosome2
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005938cell cortex IEA--

    Find genes that share ontologies with ARHGAP32           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP32 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    4G protein signaling RhoA regulation pathway
    G protein signaling RhoA regulation pathway
    5G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity


    Find genes that share SuperPaths with ARHGAP32           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for ARHGAP32
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway
    Development MAG-dependent inhibition of neurite outgrowth

    1 Reactome Pathway for ARHGAP32
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP32
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP32

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP32 (A7KAX91, 3 ENSP000003105614) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411, 3, ENSP000003576564EBI-308663,EBI-515315 I2D: score=3 STRING: ENSP00000357656
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    CRKLP461093, ENSP000003463004I2D: score=2 STRING: ENSP00000346300
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP32           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP32 (RHG32)

    3 HMDB Compounds for ARHGAP32    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    N-Methyl-D-aspartic acidN-Methyl-D-aspartate (see all 5)6384-92-5--

    2 Novoseek inferred chemical compound relationships for ARHGAP32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 48.1 1 12857875 (1)
    tyrosine 27.2 7 12788081 (3), 12454018 (2), 12446789 (1)



    Find genes that share compounds with ARHGAP32           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP32 gene (2 alternative transcripts): 
    NM_001142685.1  NM_014715.3  

    Unigene Cluster for ARHGAP32:

    Rho GTPase activating protein 32
    Hs.440379  [show with all ESTs]
    Unigene Representative Sequence: NM_001142685
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310343(uc009zco.3 uc001qez.3 uc009zcp.3) ENST00000526162
    ENST00000392657 ENST00000524655(uc009zcq.2) ENST00000527272 ENST00000534357
    ENST00000533509(uc001qfb.3) ENST00000525234
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    hsa-miR-194* hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-503 hsa-miR-29b-1* hsa-miR-649
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    Additional mRNA sequence: 

    AB018255.2 AB079856.1 AB088416.1 AK001257.1 AK023715.1 AK025237.1 AL833062.2 AY194287.1 
    BC000277.1 BC023644.2 BC051236.1 BC054488.2 BC065371.1 BC104898.1 BC113429.1 EF127492.1 

    8 DOTS entries:

    DT.95274646  DT.443620  DT.100784207  DT.100677966  DT.97801901  DT.100663234  DT.105945  DT.92469771 

    Selected AceView cDNA sequences (see all 211):

    AB018255 AK001257 BC054488 BQ011331 AA417377 AI925692 BC065371 BQ004296 
    AY194287 AL704261 AA613125 AW449641 AI672502 BC000277 AK023715 AK025237 
    AA397730 AI380022 CB155293 BM681198 BF347132 AI952937 AA478953 NM_014715 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP32    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
    SP1:                                                  -                                                     -                                                   
    SP2:                                                                                                        -                             -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     


    ECgene alternative splicing isoforms for ARHGAP32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP32 Expression
    About this image

    ARHGAP32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP32 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440379

    UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed
    in other tissues such as lung, liver and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP32 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap321 , 5 Rho GTPase activating protein 321, 5 86.18(n)1
    87.96(a)1
      9 (17.48 cM)5
    3309141  NM_001195632.11  NP_001182561.11 
     321161365 
    chicken
    (Gallus gallus)
    Aves ARHGAP321 Rho GTPase activating protein 32 68.16(n)
    66.62(a)
      419724  XM_004947962.1  XP_004948019.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP326
    Rho GTPase activating protein 32
    61(a)
    1 ↔ 1
    GL343197.1(3996964-4121353)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.345872 Xenopus laevis transcribed sequence with weak similarity more 75.51(n)    BJ088554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71500601 im:7150060 60.52(n)
    61.74(a)
      569434  XM_005161261.1  XP_005161318.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CdGAPr6
    CdGAPr
    22(a)
    1 → many
    2L(19774873-19791882)
    worm
    (Caenorhabditis elegans)
    Secernentea rrc-16
    Protein RRC-1, isoform c
    30(a)
    many ↔ many
    X(9823760-9831249) WBGene00009800
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGD16
    GTPase-activating protein (RhoGAP) for Rho3p and R...
    20(a)
    1 → many
    II(732639-734639) YBR260C


    ENSEMBL Gene Tree for ARHGAP32 (if available)
    TreeFam Gene Tree for ARHGAP32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP32 gene
    ARHGAP302  RALBP12  ARHGAP332  ARHGAP312  
    9 SIMAP similar genes for ARHGAP32 using alignment to 3 protein entries:     RHG32_HUMAN (see all proteins):
    DKFZp451F1115    RICS    SNX26    ARHGAP9    FAM13A    ARHGAP12
    ARHGAP33    ARHGAP21    CHN1

    Find genes that share paralogs with ARHGAP32           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP32 (see all 4141)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897902741,2
    --128834493(+) TGGTCA/GTTTCA 2 -- ds50010--------
    rs1455664711,2
    --128834527(+) TGTCCA/TAGATG 2 -- ds50010--------
    rs1824030711,2
    --128834541(+) CCTGGA/GAATCT 2 -- ds50010--------
    rs802028901,2
    F--128834629(+) CTCGGG/AAACCA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1378823401,2
    --128834758(+) GAAATC/TTGGCC 2 -- ds50010--------
    rs22985991,2
    C,F,A,H--128834952(+) CAAAGC/TAGTCT 2 -- ds500129Minor allele frequency- T:0.30EA NA NS CSA WA 4146
    rs1113708381,2
    C--128834954(+) AAGCAC/G/TTCTGT 2 -- ds50011CSA 1
    rs1871399851,2
    --128835375(+) TATCTC/TAGAAT 2 -- ut310--------
    rs792697351,2
    C,F--128835388(+) AAACTG/TTAAAA 2 -- ut312Minor allele frequency- T:0.08WA EA 238
    rs1171762951,2
    C,F--128835458(+) GCACAC/ATGACA 2 -- ut311Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for ARHGAP32 (128834955 - 129084955 bp, first 250kb of ARHGAP32)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP32 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661820CNV Deletion23128226
    esv2601979CNV Deletion19546169
    esv2745247CNV Deletion23290073
    esv2243084CNV Deletion18987734
    esv2287161CNV Deletion18987734
    esv2442229CNV Deletion19546169
    esv274658CNV Insertion20981092
    esv271608CNV Insertion20981092
    esv274060CNV Insertion20981092
    esv269124CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP32
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608541    OMIM disorders: --

    1 disease for ARHGAP32:    
    About MalaCards
    schizotypal personality disorder

    1 disease from the University of Copenhagen DISEASES database for ARHGAP32:
    Schizotypal personality disorder

    Find genes that share disorders with ARHGAP32           About GenesLikeMe

    1 Novoseek inferred disease relationship for ARHGAP32 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 1 17438281 (1)

    Genetic Association Database (GAD): ARHGAP32
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP32 (1 document)

    Export disorders for ARHGAP32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP32 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ARHGAP32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PubMed id 12446789)1, 2, 3, 9 Nakamura T.... Mori N. (Mol. Cell. Biol. 2002)
    2. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. (PubMed id 17663722)1, 2, 3 Hayashi T.... Nakamura T. (Genes Cells 2007)
    3. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PubMed id 12819203)1, 2, 3 Zhao C.... Feng G.S. (J. Biol. Chem. 2003)
    4. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. (PubMed id 12454018)1, 2, 9 Moon S.Y.... Zheng Y. (J. Biol. Chem. 2003)
    5. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. (PubMed id 12857875)1, 2, 9 Nakazawa T.... Yamamoto T. (Mol. Biol. Cell 2003)
    6. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PubMed id 12788081)1, 2, 9 Taniguchi S....Yamamoto T. (Biochem. Biophys. Res. Commun. 2003)
    7. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. (PubMed id 12531901)1, 2 Okabe T.... Akiyama T. (J. Biol. Chem. 2003)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    10. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits. (PubMed id 22530067)1 Ohi K....Takeda M. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9743 HGNC: 17399 AceView: RICS Ensembl:ENSG00000134909 euGenes: HUgn9743
    ECgene: ARHGAP32 H-InvDB: ARHGAP32

    (According to HUGE)
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    HUGE: KIAA0712

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP32 gene:
    Search GeneIP for patents involving ARHGAP32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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