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Aliases for ARHGAP32 Gene

Aliases for ARHGAP32 Gene

  • Rho GTPase Activating Protein 32 2 3
  • P200RhoGAP 3 4 6
  • P250GAP 3 4 6
  • GRIT 3 4 6
  • RICS 3 4 6
  • RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling 3 4
  • GAB-Associated Cdc42/Rac GTPase-Activating Protein 3 4
  • Brain-Specific Rho GTPase-Activating Protein 3 4
  • Rho/Cdc42/Rac GTPase-Activating Protein RICS 3 4
  • GTPase Regulator Interacting With TrkA 3 4
  • Rho-Type GTPase-Activating Protein 32 3 4
  • GC-GAP 3 4
  • RhoGAP Involved In The -Catenin-N-Cadherin And NMDA Receptor Signaling 3
  • Brain-Specific Rho GTP-Ase-Activating Protein 3
  • GTPase-Activating Protein For Cdc42 And Rac1 3
  • Rho GTPase-Activating Protein 32 3
  • Rac GTPase Activating Protein 3
  • GAB-Associated CDC42 3
  • KIAA0712 4
  • PX-RICS 3

External Ids for ARHGAP32 Gene

Summaries for ARHGAP32 Gene

Entrez Gene Summary for ARHGAP32 Gene

  • RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP32 Gene

ARHGAP32 (Rho GTPase Activating Protein 32) is a Protein Coding gene. Diseases associated with ARHGAP32 include schizotypal personality disorder. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for ARHGAP32 Gene

  • GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Gene Wiki entry for ARHGAP32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP32 Gene

Genomics for ARHGAP32 Gene

Genomic Location for ARHGAP32 Gene

Start:
128,965,060 bp from pter
End:
129,279,324 bp from pter
Size:
314,265 bases
Orientation:
Minus strand

Genomic View for ARHGAP32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP32 Gene

No data available for Regulatory Elements for ARHGAP32 Gene

Proteins for ARHGAP32 Gene

  • Protein details for ARHGAP32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7KAX9-RHG32_HUMAN
    Recommended name:
    Rho GTPase-activating protein 32
    Protein Accession:
    A7KAX9
    Secondary Accessions:
    • I7H0B0
    • O94820
    • Q86YL6
    • Q8IUG4
    • Q9BWG3

    Protein attributes for ARHGAP32 Gene

    Size:
    2087 amino acids
    Molecular mass:
    230529 Da
    Quaternary structure:
    • Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity).
    SequenceCaution:
    • Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP32 Gene

    Alternative splice isoforms for ARHGAP32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP32 Gene

Proteomics data for ARHGAP32 Gene at MOPED

Post-translational modifications for ARHGAP32 Gene

  • Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP32 Gene

No data available for DME Specific Peptides for ARHGAP32 Gene

Domains for ARHGAP32 Gene

Gene Families for ARHGAP32 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP32 Gene

UniProtKB/Swiss-Prot:

RHG32_HUMAN
Domain:
  • The N-terminal PX domain interacts specifically with phosphatidylinositides.:
    • A7KAX9
  • Belongs to the PX domain-containing GAP family.:
    • A7KAX9
  • Contains 1 PX (phox homology) domain.:
    • A7KAX9
  • Contains 1 Rho-GAP domain.:
    • A7KAX9
  • Contains 1 SH3 domain.:
    • A7KAX9
genes like me logo Genes that share domains with ARHGAP32: view

Function for ARHGAP32 Gene

Molecular function for ARHGAP32 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 12788081
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ARHGAP32: view
genes like me logo Genes that share phenotypes with ARHGAP32: view

Animal Models for ARHGAP32 Gene

MGI Knock Outs for ARHGAP32:

miRNA for ARHGAP32 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARHGAP32 Gene

Localization for ARHGAP32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP32 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane. Note=Association to membrane via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment. Colocalizes with GAB2 at the cell membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP32 Gene COMPARTMENTS Subcellular localization image for ARHGAP32 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005768 endosome --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP32: view

Pathways for ARHGAP32 Gene

genes like me logo Genes that share pathways with ARHGAP32: view

Gene Ontology (GO) - Biological Process for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP32: view

Compounds for ARHGAP32 Gene

(3) HMDB Compounds for ARHGAP32 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Guanosine triphosphate
  • 5'-GTP
86-01-1
N-Methyl-D-aspartic acid
  • N-Methyl-D-aspartate
6384-92-5

(2) Novoseek inferred chemical compound relationships for ARHGAP32 Gene

Compound -log(P) Hits PubMed IDs
gtp 48.1 1
tyrosine 27.2 6
genes like me logo Genes that share compounds with ARHGAP32: view

Transcripts for ARHGAP32 Gene

Unigene Clusters for ARHGAP32 Gene

Rho GTPase activating protein 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
SP1: - -
SP2: - -
SP3:
SP4: -

Relevant External Links for ARHGAP32 Gene

GeneLoc Exon Structure for
ARHGAP32
ECgene alternative splicing isoforms for
ARHGAP32

Expression for ARHGAP32 Gene

mRNA expression in normal human tissues for ARHGAP32 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP32 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP32 Gene Hs.440379

mRNA Expression by UniProt/SwissProt for ARHGAP32 Gene

A7KAX9-RHG32_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.
genes like me logo Genes that share expressions with ARHGAP32: view

Orthologs for ARHGAP32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP32 36
  • 99.54 (n)
  • 99.43 (a)
ARHGAP32 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP32 36
  • 83.09 (n)
  • 83.59 (a)
ARHGAP32 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP32 36
  • 87.95 (n)
  • 88.97 (a)
ARHGAP32 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap32 36
  • 86.18 (n)
  • 87.96 (a)
Arhgap32 16
Arhgap32 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP32 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP32 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap32 36
  • 85.81 (n)
  • 88.45 (a)
chicken
(Gallus gallus)
Aves ARHGAP32 36
  • 68.16 (n)
  • 66.62 (a)
ARHGAP32 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP32 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34587 36
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap32 36
  • 65.17 (n)
  • 66.42 (a)
zebrafish
(Danio rerio)
Actinopterygii ARHGAP32 37
  • 50 (a)
OneToOne
im:7150060 36
  • 60.52 (n)
  • 61.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 37
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rrc-1 37
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for ARHGAP32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP32 Gene

ENSEMBL:
Gene Tree for ARHGAP32 (if available)
TreeFam:
Gene Tree for ARHGAP32 (if available)

Paralogs for ARHGAP32 Gene

Paralogs for ARHGAP32 Gene

Selected SIMAP similar genes for ARHGAP32 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP32: view

Variants for ARHGAP32 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471050 -- 129,134,760(-) GGGCA(C/G)AGCCA intron-variant
rs471616 -- 129,076,912(+) ccatg(A/C/G)gacag intron-variant
rs472934 -- 129,039,985(+) GGAAC(A/C)ATGAT intron-variant
rs473616 -- 128,979,553(+) AACTA(C/T)TACTC intron-variant
rs473926 -- 129,086,549(+) gggca(C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP32 Gene

Variant ID Type Subtype PubMed ID
nsv525837 CNV Loss 19592680
esv2661820 CNV Deletion 23128226
esv274060 CNV Insertion 20981092
nsv832291 CNV Loss 17160897
esv271608 CNV Insertion 20981092
esv274658 CNV Insertion 20981092
esv2243084 CNV Deletion 18987734
esv2442229 CNV Deletion 19546169
esv269124 CNV Insertion 20981092
esv2601979 CNV Deletion 19546169
esv2287161 CNV Deletion 18987734
esv2745247 CNV Deletion 23290073
nsv826132 CNV Gain 20364138

Relevant External Links for ARHGAP32 Gene

HapMap Linkage Disequilibrium report
ARHGAP32

Disorders for ARHGAP32 Gene

(1) University of Copenhagen DISEASES for ARHGAP32 Gene

(1) Novoseek inferred disease relationships for ARHGAP32 Gene

Disease -log(P) Hits PubMed IDs
tumors 0.976 1

Relevant External Links for ARHGAP32

Genetic Association Database (GAD)
ARHGAP32
Human Genome Epidemiology (HuGE) Navigator
ARHGAP32
genes like me logo Genes that share disorders with ARHGAP32: view

No data available for UniProtKB/Swiss-Prot for ARHGAP32 Gene

Publications for ARHGAP32 Gene

  1. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PMID: 12446789) Nakamura T. … Mori N. (Mol. Cell. Biol. 2002) 2 3 4 23
  2. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. (PMID: 12454018) Moon S.Y. … Zheng Y. (J. Biol. Chem. 2003) 3 4 23
  3. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PMID: 12819203) Zhao C. … Feng G.S. (J. Biol. Chem. 2003) 2 3 4
  4. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S. … Yamamoto T. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  5. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. (PMID: 12857875) Nakazawa T. … Yamamoto T. (Mol. Biol. Cell 2003) 3 4 23

Products for ARHGAP32 Gene

Sources for ARHGAP32 Gene

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