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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP32 Gene

protein-coding   GIFtS: 59
GCID: GC11M128834

Rho GTPase Activating Protein 32

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 321 2     p200RhoGAP2 3
Brain-Specific Rho GTPase-Activating Protein2 3     p250GAP2 3
Rho-Type GTPase-Activating Protein 322 3     PX-RICS2
Rho/Cdc42/Rac GTPase-Activating Protein RICS2 3     Brain-Specific Rho GTP-Ase-Activating Protein2
RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling2 3     GAB-Associated CDC422
GC-GAP2 3     GTPase-Activating Protein For Cdc42 And Rac12
GRIT2 3     Rac GTPase Activating Protein2
RICS2 3     Rho GTPase-Activating Protein 322
GAB-Associated Cdc42/Rac GTPase-Activating Protein2 3     RhoGAP Involved In The -Catenin-N-Cadherin And NMDA Receptor Signaling2
GTPase Regulator Interacting With TrkA2 3     KIAA07123

External Ids:    HGNC: 173991   Entrez Gene: 97432   Ensembl: ENSG000001349097   OMIM: 6085415   UniProtKB: A7KAX93   

Export aliases for ARHGAP32 gene to outside databases

Previous GC identifer: GC11M124785


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP32 Gene:
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by
modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 (PubMed 12531901)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for ARHGAP32 Gene: 
ARHGAP32 (Rho GTPase activating protein 32) is a protein-coding gene. Diseases associated with ARHGAP32 include schizotypal personality disorder, and dentin sensitivity, and among its related super-pathways are Signaling by Rho GTPases and G-protein signaling Regulation of RAC1 activity. GO annotations related to this gene include phosphatidylinositol binding and GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
Function: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be
involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA
receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and
Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity)

Gene Wiki entry for ARHGAP32 (RICS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGAP32
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP32 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.3

ARHGAP32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128834:  view genomic region     (about GC identifiers)

Start:
128,834,955 bp from pter      End:
129,149,219 bp from pter
Size:
314,265 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 32  
Size: 2087 amino acids; 230529 Da
Subunit: Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation
state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is
necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with
GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1
may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex.
Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32.
Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the
interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection,
dendritic spine (By similarity). Cytoplasm, cell cortex. Endosome membrane (By similarity). Golgi apparatus
membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Membrane. Note=Association to membrane
via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic
spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane
upon EGF treatment. Colocalizes with GAB2 at the cell membrane
Sequence caution: Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ARHGAP32:
3IUG (3D)    
Secondary accessions: O94820 Q86YL6 Q8IUG4 Q9BWG3
Alternative splicing: 3 isoforms:  A7KAX9-1   A7KAX9-2   A7KAX9-3   

Explore the universe of human proteins at neXtProt for ARHGAP32: NX_A7KAX9

Explore proteomics data for ARHGAP32 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo
    dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the
    presence of calmodulin and calcium; which inhibits GAP activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A7KAX9

  • ARHGAP32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP32 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136157.1  NP_055530.2  

    ENSEMBL proteins: 
     ENSP00000310561   ENSP00000376425   ENSP00000432468   ENSP00000432862   ENSP00000432303  
    Reactome Protein details: A7KAX9
    Human Recombinant Protein Products for ARHGAP32: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    ARHGAP32 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001683 Phox
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry A7KAX9

    ProtoNet protein and cluster: A7KAX9

    UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
    Domain: The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)
    Similarity: Belongs to the PX domain-containing GAP family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    ARHGAP32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG32_HUMAN, A7KAX9
    Function: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be
    involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA
    receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and
    Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI12788081
    GO:0035091phosphatidylinositol binding IEA--
         
    ARHGAP32 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP32:
     Decreased p24 protein expressi  Increased viability after born 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap32):
     cellular  nervous system  reproductive system 

    ARHGAP32 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgap32tm1Taki for ARHGAP32

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    hsa-miR-194* hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-503 hsa-miR-29b-1* hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP32 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP32 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    2G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    3Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    4Signaling by GPCR
    Signal Transduction0.55
    5G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ARHGAP32
        G-protein signaling Regulation of CDC42 activity
    Development MAG-dependent inhibition of neurite outgrowth
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity


    4 GeneGo (Thomson Reuters) Pathways for ARHGAP32
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway
    Development MAG-dependent inhibition of neurite outgrowth

    3        Reactome Pathways for ARHGAP32
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP32 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP32

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for ARHGAP32 (A7KAX91, 3 ENSP000003105614) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411, 3, ENSP000003576564EBI-308663,EBI-515315 I2D: score=3 STRING: ENSP00000357656
    GRIN2BQ132243, ENSP000002795934I2D: score=3 STRING: ENSP00000279593
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARHGAP32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGAP32 (RHG32)

    3 HMDB Compounds for ARHGAP32    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    N-Methyl-D-aspartic acidN-Methyl-D-aspartate (see all 5)6384-92-5--

    2 Novoseek inferred chemical compound relationships for ARHGAP32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 48.1 1 12857875 (1)
    tyrosine 27.2 7 12788081 (3), 12454018 (2), 12446789 (1)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP32 / RHG32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP32 gene (2 alternative transcripts): 
    NM_001142685.1  NM_014715.3  

    Unigene Cluster for ARHGAP32:

    Rho GTPase activating protein 32
    Hs.440379  [show with all ESTs]
    Unigene Representative Sequence: NM_001142685
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310343(uc009zco.3 uc001qez.3 uc009zcp.3) ENST00000526162
    ENST00000392657 ENST00000524655(uc009zcq.2) ENST00000527272 ENST00000534357
    ENST00000533509(uc001qfb.3) ENST00000525234
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    Additional mRNA sequence: 

    AB018255.2 AB079856.1 AB088416.1 AK001257.1 AK023715.1 AK025237.1 AL833062.2 AY194287.1 
    BC000277.1 BC023644.2 BC051236.1 BC054488.2 BC065371.1 BC104898.1 BC113429.1 EF127492.1 

    8 DOTS entries:

    DT.95274646  DT.443620  DT.100784207  DT.100677966  DT.97801901  DT.100663234  DT.105945  DT.92469771 

    24/211 AceView cDNA sequences (see all 211):

    BC054488 AK023715 BU170535 AA397730 AW778955 BF347132 BU542989 AB018255 
    AU124567 AI672502 AB079856 BX281129 AA478953 AA626240 BQ188365 BU178930 
    AW449641 BC065371 AI952937 C20906 AL704261 AK025237 AA613125 AW515221 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP32    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
    SP1:                                                  -                                                     -                                                   
    SP2:                                                                                                        -                             -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     


    ECgene alternative splicing isoforms for ARHGAP32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP32 Expression
    About this image


    See ARHGAP32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP32

    SOURCE GeneReport for Unigene cluster: Hs.440379

    UniProtKB/Swiss-Prot: RHG32_HUMAN, A7KAX9
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed
    in other tissues such as lung, liver and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP32 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap321 , 5 Rho GTPase activating protein 321, 5 86.18(n)1
    87.96(a)1
      9 (17.48 cM)5
    3309141  NM_001195632.11  NP_001182561.11 
     321161365 
    chicken
    (Gallus gallus)
    Aves ARHGAP321 Rho GTPase activating protein 32 68.44(n)
    67.17(a)
      419724  XM_417865.3  XP_417865.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP326
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343197.1(3996964-4121353)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.345872 Xenopus laevis transcribed sequence with weak similarity more 75.51(n)    BJ088554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71500601 im:7150060 57.74(n)
    57.96(a)
      569434  XM_692818.5  XP_697910.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP18B6
    CdGAPr6
    CdGAPr
    7(a)
    19(a)
    possible ortholog
    1 ↔ many
    X(19030259-19059362)
    2L(19774873-19791882)
    worm
    (Caenorhabditis elegans)
    Secernentea rrc-16
    GTPase-activating protein rrc-1
    27(a)
    possible ortholog
    X(9823760-9831249)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGA16
    RGA26
    GTPase-activating protein for the polarity-establi...
    GTPase-activating protein for the polarity-establi...
    9(a)
    8(a)
    many ↔ many
    many ↔ many
    XV(561170-564193)
    IV(1230167-1233196)


    ENSEMBL Gene Tree for ARHGAP32 (if available)
    TreeFam Gene Tree for ARHGAP32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP32 gene
    ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP232  ARHGAP332  ARHGAP92  ARHGAP262  
    CHN12  ARHGAP302  ARHGAP152  ARHGAP122  OPHN12  ARHGAP422  ARHGAP312  
    9 SIMAP similar genes for ARHGAP32 using alignment to 3 protein entries:     RHG32_HUMAN (see all proteins):
    DKFZp451F1115    RICS    SNX26    ARHGAP33    ARHGAP9    FAM13A
    ARHGAP12    ARHGAP21    CHN1

    ARHGAP32 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4141 SNPs in ARHGAP32 are shown (see all 4141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897902741,2
    --128834493(+) TGGTCA/GTTTCA 2 -- ds50010--------
    rs1455664711,2
    --128834527(+) TGTCCA/TAGATG 2 -- ds50010--------
    rs1824030711,2
    --128834541(+) CCTGGA/GAATCT 2 -- ds50010--------
    rs802028901,2
    F--128834629(+) CTCGGG/AAACCA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1378823401,2
    --128834758(+) GAAATC/TTGGCC 2 -- ds50010--------
    rs22985991,2
    C,F,A,H--128834952(+) CAAAGC/TAGTCT 2 -- ds500129Minor allele frequency- T:0.30EA NA NS CSA WA 4146
    rs1113708381,2
    C--128834954(+) AAGCAC/G/TTCTGT 2 -- ds50011CSA 1
    rs1871399851,2
    --128835375(+) TATCTC/TAGAAT 2 -- ut310--------
    rs792697351,2
    C,F--128835388(+) AAACTG/TTAAAA 2 -- ut312Minor allele frequency- T:0.08WA EA 238
    rs1171762951,2
    C,F--128835458(+) GCACAC/ATGACA 2 -- ut311Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for ARHGAP32 (128834955 - 129084955 bp, first 250kb of ARHGAP32)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ARHGAP32 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661820CNV Deletion23128226
    esv2601979CNV Deletion19546169
    esv2745247CNV Deletion23290073
    esv2243084CNV Deletion18987734
    esv2287161CNV Deletion18987734
    esv2442229CNV Deletion19546169
    esv274658CNV Insertion20981092
    esv271608CNV Insertion20981092
    esv274060CNV Insertion20981092
    esv269124CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608541    OMIM disorders: --

    7 diseases for ARHGAP32:    About MalaCards
    schizotypal personality disorder    dentin sensitivity    enamel erosion    folliculitis
    personality disorder    neuroblastoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARHGAP32:
    Schizotypal personality disorder

    ARHGAP32 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ARHGAP32 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 1 17438281 (1)

    Genetic Association Database (GAD): ARHGAP32
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP32 (1 document)

    Export disorders for ARHGAP32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP32 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ARHGAP32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PubMed id 12446789)1, 2, 3, 9 Nakamura T.... Mori N. (2002)
    2. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. (PubMed id 17663722)1, 2, 3 Hayashi T.... Nakamura T. (2007)
    3. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PubMed id 12819203)1, 2, 3 Zhao C.... Feng G.S. (2003)
    4. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. (PubMed id 12454018)1, 2, 9 Moon S.Y....Zheng Y. (2003)
    5. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. (PubMed id 12857875)1, 2, 9 Nakazawa T....Yamamoto T. (2003)
    6. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PubMed id 12788081)1, 2, 9 Taniguchi S....Yamamoto T. (2003)
    7. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. (PubMed id 12531901)1, 2 Okabe T.... Akiyama T. (2003)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    9. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (2013)
    10. The p250GAP gene is associated with risk for schizophr enia and schizotypal personality traits. (PubMed id 22530067)1 Ohi K....Takeda M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9743 HGNC: 17399 AceView: RICS Ensembl:ENSG00000134909 euGenes: HUgn9743
    ECgene: ARHGAP32 H-InvDB: ARHGAP32

    (According to HUGE)
    About This Section
    HUGE: KIAA0712

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP32 gene:
    Search GeneIP for patents involving ARHGAP32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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