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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP31 Gene

protein-coding   GIFtS: 59
GCID: GC03P119013

Rho GTPase Activating Protein 31

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 311 2
CDGAP2 3 5
Cdc42 GTPase-Activating Protein2 3
KIAA12043 5
AOS12
Rho GTPase-Activating Protein 312

External Ids:    HGNC: 292161   Entrez Gene: 575142   Ensembl: ENSG000000310817   OMIM: 6109115   UniProtKB: Q2M1Z33   

Export aliases for ARHGAP31 gene to outside databases

Previous GC identifer: GC03P116388


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP31 Gene:
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases
which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive
and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown
to regulate two GTPases involved in protein trafficking and cell growth. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGAP31 Gene: 
ARHGAP31 (Rho GTPase activating protein 31) is a protein-coding gene. Diseases associated with ARHGAP31 include adams-oliver syndrome 1, and adams oliver syndrome, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding and GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG31_HUMAN, Q2M1Z3
Function: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading,
polarized lamellipodia formation and cell migration

Gene Wiki entry for ARHGAP31 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGAP31
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP31 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP31

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

ARHGAP31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP31 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P119013:  view genomic region     (about GC identifiers)

Start:
119,013,220 bp from pter      End:
119,139,561 bp from pter
Size:
126,342 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG31_HUMAN, Q2M1Z3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 31  
Size: 1444 amino acids; 156985 Da
Subunit: Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA (By similarity). Interacts with
GTP-loaded RHOU
Subcellular location: Cell projection, lamellipodium. Cell junction, focal adhesion (By similarity)
Developmental stage: Mainly expressed in fetal heart and muscle
Sequence caution: Sequence=BAA86518.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9ULL6

Explore the universe of human proteins at neXtProt for ARHGAP31: NX_Q2M1Z3

Explore proteomics data for ARHGAP31 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Thr-789 reduces GAP activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2M1Z3

  • ARHGAP31 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP31 Protein Expression
    REFSEQ proteins: NP_065805.2  
    ENSEMBL proteins: 
     ENSP00000264245   ENSP00000418429  
    Reactome Protein details: Q2M1Z3
    Human Recombinant Protein Products for ARHGAP31: 
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    Novus Biologicals ARHGAP31 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGAP31 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IEA--
    GO:0030027lamellipodium IEA--

    ARHGAP31 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q2M1Z3

    ProtoNet protein and cluster: Q2M1Z3

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG31_HUMAN, Q2M1Z3
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP31 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG31_HUMAN, Q2M1Z3
    Function: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading,
    polarized lamellipodia formation and cell migration

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--
         
    ARHGAP31 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGAP31 
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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP31 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP31 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ARHGAP31
        G-protein signaling Regulation of CDC42 activity


    1 Cell Signaling Technology (CST) Pathway for ARHGAP31
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for ARHGAP31
        G-protein signaling Regulation of CDC42 activity

    3        Reactome Pathways for ARHGAP31
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP31 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for ARHGAP31 (Q2M1Z32, 3 ENSP000002642454) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, 3, ENSP000003707194MINT-7302489 I2D: score=4 STRING: ENSP00000370719
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    RAC1P630003, ENSP000003484614I2D: score=4 STRING: ENSP00000348461
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0043547positive regulation of GTPase activity ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP31 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP31 (RHG31)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP31 / RHG31

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP31 gene: 
    NM_020754.2  

    Unigene Cluster for ARHGAP31:

    Rho GTPase activating protein 31
    Hs.668218  [show with all ESTs]
    Unigene Representative Sequence: NM_020754
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264245(uc003ecj.4) ENST00000482743
    miRNA
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    hsa-miR-582-3p hsa-miR-29a hsa-miR-4267 hsa-miR-3161 hsa-miR-1243 hsa-miR-761 hsa-miR-4264 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP31 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP31

    Additional mRNA sequence: 

    AB033030.1 AK026689.1 BC112163.1 BC112165.1 

    2 DOTS entries:

    DT.112150  DT.120859534 

    24/90 AceView cDNA sequences (see all 90):

    AA743273 AA296608 AW954242 CA437092 AA458627 BU732138 AB033030 AA425616 
    AA933880 BX952664 BM708381 BF917726 BI907556 AA424335 CA309030 AW262783 
    BG820846 BX507186 H24948 CD105527 CA446668 AA425435 BI818160 BQ181407 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP31 expression in normal human tissues (normalized intensities)      ARHGAP31 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTTCCCT
    ARHGAP31 Expression
    About this image


    ARHGAP31 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human umbilical vein endothelial cells (HUVEC)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
             cd31+ cells   
     
     Blood (Respiratory System)    fully expand to see all 3 entries
             monocyte-derived dendritic cells   
     
     Surface Ectoderm (Integumentary System)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Surface Ectoderm
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Epidermis (Integumentary System)
             Surface Ectoderm Cells Surface Ectoderm

    See ARHGAP31 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP31

    SOURCE GeneReport for Unigene cluster: Hs.668218
        SABiosciences Custom PCR Arrays for ARHGAP31
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP31 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap311 , 5 Rho GTPase activating protein 311, 5 82.72(n)1
    79.45(a)1
      16 (26.87 cM)5
    125491  NM_020260.21  NP_064656.21 
     385983405 
    chicken
    (Gallus gallus)
    Aves ARHGAP311 Rho GTPase activating protein 31 60.42(n)
    56.92(a)
      418344  XM_416566.2  XP_416566.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP316
    Rho GTPase activating protein 31
    48(a)
    1 ↔ 1
    3(180921312-181043748)
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap316
    Rho GTPase activating protein 31
    35(a)
    1 ↔ 1
    5(70667694-70717855)
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP18B6
    CdGAPr6
    CdGAPr
    4(a)
    13(a)
    possible ortholog
    1 ↔ many
    X(19030259-19059362)
    2L(19774873-19791882)
    worm
    (Caenorhabditis elegans)
    Secernentea rrc-16
    GTPase-activating protein rrc-1
    16(a)
    possible ortholog
    X(9823760-9831249)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGA26
    RGA16
    GTPase-activating protein for the polarity-establi...
    GTPase-activating protein for the polarity-establi...
    6(a)
    6(a)
    many ↔ many
    many ↔ many
    IV(1230167-1233196)
    XV(561170-564193)


    ENSEMBL Gene Tree for ARHGAP31 (if available)
    TreeFam Gene Tree for ARHGAP31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP31 gene
    ARHGAP212  ARHGAP272  ARHGAP322  ARHGAP102  CHN22  ARHGAP232  ARHGAP332  ARHGAP92  
    ARHGAP262  CHN12  ARHGAP302  ARHGAP152  ARHGAP122  OPHN12  ARHGAP422  
    18/23 SIMAP similar genes for ARHGAP31 using alignment to 2 protein entries:     RHG31_HUMAN (see all proteins) (see all similar genes):
    ARHGAP33    RICS    ARHGAP12    ARHGAP42    CHN2-3    OPHN1
    CHN1    CHN2    MYO9A    ARHGAP10    ARHGAP24    ARHGAP44
    SH3BP1    ABR    ARHGAP27    FAM13A    HMHA1    DLC1

    ARHGAP31 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2752 SNPs in ARHGAP31 are shown (see all 2752)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659194
    ----see VAR_0659192 T I mis40--------
    rs680953181,2
    C--116386877(+) GACTG-/CGGGAG 1 -- us2k10--------
    rs2013054431,2
    C--116389452(-) AAAAAA/GGAAAA 1 -- int10--------
    rs765703941,2
    C--116391824(+) TTGAG-/AC/CA 
            
    AGGAA
    1 -- int10--------
    rs106430891,2
    C--116391826(+) TGAGA-/AC/CA 
            
    GGAAA
    1 -- int1 trp30--------
    rs1134646871,2
    C--116392220(+) CACAC-/ACCGTGT 1 -- int11Minor allele frequency- AC:0.50CSA 2
    rs105751451,2
    C--116392221(+) TAGAA-/ACACACA 1 -- int10--------
    rs113470201,2
    C,F--116395956(+) GACTGT/-TTTTT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs2012636761,2
    --116415966(+) CGTAG-/GTTTT 
            
    GTTTT
    1 -- int10--------
    rs1391588601,2
    C--116420786(+) AACTT-/AAGAAA
            
    GTATG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGAP31 (119013220 - 119139561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGAP31:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997290CNV Deletion20482838
    nsv822227CNV Loss20364138
    nsv3962CNV Loss18451855
    nsv829694CNV Gain17160897


    Human Gene Mutation Database (HGMD): ARHGAP31
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610911    OMIM disorders: --

    UniProtKB/Swiss-Prot: RHG31_HUMAN, Q2M1Z3
  • Adams-Oliver syndrome 1 (AOS1) [MIM:100300]: A disorder characterized by the congenital absence of skin
    (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located
    anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where
    it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb
    truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely,
    metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects,
    syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly
    variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as
    cutis marmorata and dilated scalp veins. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 10 diseases for ARHGAP31:    About MalaCards
    adams-oliver syndrome 1    adams oliver syndrome    oliver syndrome    aplasia cutis congenita
    aortic atherosclerosis    birth defects    syndactyly    celiac disease
    atherosclerosis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARHGAP31:
    Aortic atherosclerosis

    ARHGAP31 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP31
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP31 (0 documents)

    Export disorders for ARHGAP31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP31 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGAP31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human orthologue of CdGAP is a phosphoprotein and a GTPase- activating protein for Cdc42 and Rac1 but not RhoA. (PubMed id 16519628)1, 2, 3, 9 Tcherkezian J.... Lamarche-Vane N. (2006)
    2. Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies. (PubMed id 21565291)1, 2 Southgate L....Trembath R.C. (2011)
    3. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    4. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PubMed id 12819203)1, 3 Zhao C.... Feng G.S. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    6. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. (PubMed id 9786927)1, 3 Lamarche-Vane N. and Hall A. (1998)
    7. A comprehensive family-based replication study of schi zophrenia genes. (PubMed id 23894747)1 Aberg K.A....van den Oord E.J. (2013)
    8. CdGAP regulates cell migration and adhesion dynamics i n two-and three-dimensional matrix environments. (PubMed id 22907917)1 Wormer D....Turner C.E. (2012)
    9. A stretch of polybasic residues mediates Cdc42 GTPase- activating protein (CdGAP) binding to phosphatidylinositol 3,4,5-trisphosphate a nd regulates its GAP activity. (PubMed id 22518840)1 Karimzadeh F....Lamarche-Vane N. (2012)
    10. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PubMed id 21565175)2 Naji L.... Aspenstrom P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57514 HGNC: 29216 AceView: CDGAP Ensembl:ENSG00000031081 euGenes: HUgn57514
    ECgene: ARHGAP31 H-InvDB: ARHGAP31

    (According to HUGE)
    About This Section
    HUGE: KIAA1204

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP31 gene:
    Search GeneIP for patents involving ARHGAP31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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