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Aliases for ARHGAP30 Gene

Aliases for ARHGAP30 Gene

  • Rho GTPase Activating Protein 30 2 3
  • Rho-Type GTPase-Activating Protein 30 4

External Ids for ARHGAP30 Gene

Previous GeneCards Identifiers for ARHGAP30 Gene

  • GC01M157830
  • GC01M159283
  • GC01M132374

Summaries for ARHGAP30 Gene

GeneCards Summary for ARHGAP30 Gene

ARHGAP30 (Rho GTPase Activating Protein 30) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for ARHGAP30 Gene

  • GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP30 Gene

Genomics for ARHGAP30 Gene

Regulatory Elements for ARHGAP30 Gene

Genomic Location for ARHGAP30 Gene

Chromosome:
1
Start:
161,046,942 bp from pter
End:
161,069,971 bp from pter
Size:
23,030 bases
Orientation:
Minus strand

Genomic View for ARHGAP30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP30 Gene

Proteins for ARHGAP30 Gene

  • Protein details for ARHGAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6I6-RHG30_HUMAN
    Recommended name:
    Rho GTPase-activating protein 30
    Protein Accession:
    Q7Z6I6
    Secondary Accessions:
    • Q5SY52
    • Q5SY53
    • Q5SY54
    • Q6ZML6
    • Q7Z3J8
    • Q86XI7

    Protein attributes for ARHGAP30 Gene

    Size:
    1101 amino acids
    Molecular mass:
    118582 Da
    Quaternary structure:
    • Interacts with RHOU in a GTP-independent manner.
    SequenceCaution:
    • Sequence=AAH43387.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD18709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI15373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP30 Gene

Proteomics data for ARHGAP30 Gene at MOPED

Post-translational modifications for ARHGAP30 Gene

  • Ubiquitination at Lys 181
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ARHGAP30 Gene

Domains & Families for ARHGAP30 Gene

Gene Families for ARHGAP30 Gene

Protein Domains for ARHGAP30 Gene

Suggested Antigen Peptide Sequences for ARHGAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6I6

UniProtKB/Swiss-Prot:

RHG30_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP30: view

Function for ARHGAP30 Gene

Molecular function for ARHGAP30 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

Gene Ontology (GO) - Molecular Function for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP30: view

Phenotypes for ARHGAP30 Gene

genes like me logo Genes that share phenotypes with ARHGAP30: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP30

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP30 Gene

Localization for ARHGAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP30 Gene COMPARTMENTS Subcellular localization image for ARHGAP30 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARHGAP30: view

Pathways & Interactions for ARHGAP30 Gene

genes like me logo Genes that share pathways with ARHGAP30: view

Pathways by source for ARHGAP30 Gene

3 Reactome pathways for ARHGAP30 Gene

Gene Ontology (GO) - Biological Process for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

No data available for SIGNOR curated interactions for ARHGAP30 Gene

Drugs & Compounds for ARHGAP30 Gene

No Compound Related Data Available

Transcripts for ARHGAP30 Gene

Unigene Clusters for ARHGAP30 Gene

Rho GTPase activating protein 30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP30

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP30 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9: - - - - - - - -

Relevant External Links for ARHGAP30 Gene

GeneLoc Exon Structure for
ARHGAP30
ECgene alternative splicing isoforms for
ARHGAP30

Expression for ARHGAP30 Gene

mRNA expression in normal human tissues for ARHGAP30 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP30 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for ARHGAP30 Gene

This gene is overexpressed in Pancreas (22.5), Peripheral blood mononuclear cells (12.8), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP30 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP30 Gene Hs.389374

genes like me logo Genes that share expression patterns with ARHGAP30: view

Protein tissue co-expression partners for ARHGAP30 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP30 Gene

Orthologs for ARHGAP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP30 35
  • 85.82 (n)
  • 85.31 (a)
ARHGAP30 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP30 35
  • 84.05 (n)
  • 82.01 (a)
ARHGAP30 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap30 35
  • 81.01 (n)
  • 76.69 (a)
Arhgap30 16
Arhgap30 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP30 35
  • 99.63 (n)
  • 99.81 (a)
ARHGAP30 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap30 35
  • 80.89 (n)
  • 77.51 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP30 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP30 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU915267.1 36
  • 66 (a)
OneToMany
CU915267.1 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 36
  • 12 (a)
OneToMany
Species with no ortholog for ARHGAP30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP30 Gene

ENSEMBL:
Gene Tree for ARHGAP30 (if available)
TreeFam:
Gene Tree for ARHGAP30 (if available)

Paralogs for ARHGAP30 Gene

Paralogs for ARHGAP30 Gene

(4) SIMAP similar genes for ARHGAP30 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGAP30: view

Variants for ARHGAP30 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP30 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1467739 -- 161,055,110(-) ACTGA(A/G)AGACC intron-variant
rs1467740 -- 161,055,089(-) GCAGC(A/C)CCCTG intron-variant
rs1467741 -- 161,054,986(-) CCACT(A/G)AAGTA intron-variant
rs1556256 -- 161,053,584(-) TCCTA(A/G)AAGTC intron-variant
rs1974140 -- 161,054,023(-) cggtg(C/T)gatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP30 Gene

Variant ID Type Subtype PubMed ID
nsv3221 CNV Loss 18451855
nsv3232 CNV Insertion 18451855

Variation tolerance for ARHGAP30 Gene

Residual Variation Intolerance Score: 73.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP30 Gene

HapMap Linkage Disequilibrium report
ARHGAP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Disorders for ARHGAP30 Gene

Relevant External Links for ARHGAP30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP30
genes like me logo Genes that share disorders with ARHGAP30: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP30 Gene

Publications for ARHGAP30 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 67
  3. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PMID: 21565175) Naji L. … Aspenstrom P. (Biochem. Biophys. Res. Commun. 2011) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67

Products for ARHGAP30 Gene

Sources for ARHGAP30 Gene

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