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Aliases for ARHGAP30 Gene

Aliases for ARHGAP30 Gene

  • Rho GTPase Activating Protein 30 2 3 5
  • Rho-Type GTPase-Activating Protein 30 4

External Ids for ARHGAP30 Gene

Previous GeneCards Identifiers for ARHGAP30 Gene

  • GC01M157830
  • GC01M159283
  • GC01M132374

Summaries for ARHGAP30 Gene

GeneCards Summary for ARHGAP30 Gene

ARHGAP30 (Rho GTPase Activating Protein 30) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP32.

UniProtKB/Swiss-Prot for ARHGAP30 Gene

  • GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP30 Gene

Genomics for ARHGAP30 Gene

Regulatory Elements for ARHGAP30 Gene

Enhancers for ARHGAP30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F161011 1.2 FANTOM5 ENCODE 33.7 +52.8 52758 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DUSP12 ARHGAP30 TSTD1 ENSG00000228606 FCGR2A USF1 RPSAP18 CD48 DEDD KLHDC9
GH01F161043 0.4 ENCODE 23.5 +23.1 23083 5.8 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ARHGAP30 TSTD1 LOC105371471 NECTIN4 KLHDC9 CD48 DUSP12 UFC1 ENSG00000224985 USP21
GH01F161066 1 FANTOM5 ENCODE 18.4 +1.4 1357 5.1 HDGF PKNOX1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 SP3 FCGR2A TSTD1 DUSP12 ENSG00000228606 ARHGAP30 F11R DEDD ATF6 NECTIN4 ENSG00000232879
GH01F160989 0.5 Ensembl ENCODE 11.4 +79.6 79581 1.2 PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 BRCA1 ZNF2 ZNF121 GTF3C2 ELK1 F11R ENSG00000232879 ENSG00000228606 TSTD1 ARHGAP30 CD48 DUSP12 SLAMF7 ENSG00000228863 SLAMF1
GH01F161196 1.2 FANTOM5 ENCODE 11.4 -130.1 -130100 8.0 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610 B4GALT3 NDUFS2 ARHGAP30 CD48 DUSP12 ADAMTS4 NIT1 TOMM40L PCP4L1 FCER1G
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGAP30 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167145 1071 2201 HDGF PKNOX1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 SP3

Genomic Location for ARHGAP30 Gene

Chromosome:
1
Start:
161,046,942 bp from pter
End:
161,069,971 bp from pter
Size:
23,030 bases
Orientation:
Minus strand

Genomic View for ARHGAP30 Gene

Genes around ARHGAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP30 Gene

Proteins for ARHGAP30 Gene

  • Protein details for ARHGAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6I6-RHG30_HUMAN
    Recommended name:
    Rho GTPase-activating protein 30
    Protein Accession:
    Q7Z6I6
    Secondary Accessions:
    • Q5SY52
    • Q5SY53
    • Q5SY54
    • Q6ZML6
    • Q7Z3J8
    • Q86XI7

    Protein attributes for ARHGAP30 Gene

    Size:
    1101 amino acids
    Molecular mass:
    118582 Da
    Quaternary structure:
    • Interacts with RHOU in a GTP-independent manner.
    SequenceCaution:
    • Sequence=AAH43387.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD18709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI15373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP30 Gene

Post-translational modifications for ARHGAP30 Gene

  • Ubiquitination at Lys 181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP30 Gene

Domains & Families for ARHGAP30 Gene

Gene Families for ARHGAP30 Gene

Protein Domains for ARHGAP30 Gene

Suggested Antigen Peptide Sequences for ARHGAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6I6

UniProtKB/Swiss-Prot:

RHG30_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP30: view

Function for ARHGAP30 Gene

Molecular function for ARHGAP30 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

Gene Ontology (GO) - Molecular Function for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

Phenotypes for ARHGAP30 Gene

genes like me logo Genes that share phenotypes with ARHGAP30: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP30 Gene

Localization for ARHGAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP30 Gene COMPARTMENTS Subcellular localization image for ARHGAP30 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARHGAP30: view

Pathways & Interactions for ARHGAP30 Gene

genes like me logo Genes that share pathways with ARHGAP30: view

Pathways by source for ARHGAP30 Gene

3 Reactome pathways for ARHGAP30 Gene

Gene Ontology (GO) - Biological Process for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

No data available for SIGNOR curated interactions for ARHGAP30 Gene

Transcripts for ARHGAP30 Gene

Unigene Clusters for ARHGAP30 Gene

Rho GTPase activating protein 30:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP30 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9: - - - - - - - -

Relevant External Links for ARHGAP30 Gene

GeneLoc Exon Structure for
ARHGAP30
ECgene alternative splicing isoforms for
ARHGAP30

Expression for ARHGAP30 Gene

mRNA expression in normal human tissues for ARHGAP30 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP30 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for ARHGAP30 Gene

This gene is overexpressed in Pancreas (22.5), Peripheral blood mononuclear cells (12.8), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP30 Gene



Protein tissue co-expression partners for ARHGAP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP30 Gene:

ARHGAP30

SOURCE GeneReport for Unigene cluster for ARHGAP30 Gene:

Hs.389374
genes like me logo Genes that share expression patterns with ARHGAP30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP30 Gene

Orthologs for ARHGAP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP30 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia ARHGAP30 34 35
  • 85.82 (n)
dog
(Canis familiaris)
Mammalia ARHGAP30 34 35
  • 84.05 (n)
mouse
(Mus musculus)
Mammalia Arhgap30 34 16 35
  • 81.01 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap30 34
  • 80.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP30 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP30 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU915267.1 35 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 35
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 35
  • 12 (a)
OneToMany
Species where no ortholog for ARHGAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP30 Gene

ENSEMBL:
Gene Tree for ARHGAP30 (if available)
TreeFam:
Gene Tree for ARHGAP30 (if available)

Paralogs for ARHGAP30 Gene

Paralogs for ARHGAP30 Gene

(4) SIMAP similar genes for ARHGAP30 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGAP30: view

Variants for ARHGAP30 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP30 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158361 -- 161,054,209(+) CCATC(C/T)GACCC intron-variant
rs10603448 -- 161,064,846(+) GAAAG(-/AAAG)GAAAG intron-variant
rs10737178 -- 161,057,702(+) TTTAC(A/G)TTTAC intron-variant
rs10797091 -- 161,057,875(+) ggctg(A/G)gcatg intron-variant
rs10797092 -- 161,067,252(+) AGGCC(A/C)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1129471 CNV tandem duplication 24896259
nsv1149777 CNV insertion 26484159
nsv3221 CNV deletion 18451855
nsv3232 CNV insertion 18451855

Variation tolerance for ARHGAP30 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Disorders for ARHGAP30 Gene

Relevant External Links for ARHGAP30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP30

No disorders were found for ARHGAP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP30 Gene

Publications for ARHGAP30 Gene

  1. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PMID: 21565175) Naji L. … Aspenstrom P. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. ArhGAP30 promotes p53 acetylation and function in colorectal cancer. (PMID: 25156493) Wang J. … Fang J.Y. (Nat Commun 2014) 3 64

Products for ARHGAP30 Gene

Sources for ARHGAP30 Gene

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