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Aliases for ARHGAP29 Gene

Aliases for ARHGAP29 Gene

  • Rho GTPase Activating Protein 29 2 3 5
  • Rho-Type GTPase-Activating Protein 29 3 4
  • PTPL1-Associated RhoGAP Protein 1 3 4
  • PARG1 3 4
  • PTPL1-Associated RhoGAP 1 (PARG1) 3

External Ids for ARHGAP29 Gene

Previous GeneCards Identifiers for ARHGAP29 Gene

  • GC01M094350
  • GC01M094407
  • GC01M094634
  • GC01M092755
  • GC01M094616

Summaries for ARHGAP29 Gene

GeneCards Summary for ARHGAP29 Gene

ARHGAP29 (Rho GTPase Activating Protein 29) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and PDZ domain binding. An important paralog of this gene is ABR.

UniProtKB/Swiss-Prot for ARHGAP29 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP29 Gene

Genomics for ARHGAP29 Gene

Regulatory Elements for ARHGAP29 Gene

Genomic Location for ARHGAP29 Gene

Chromosome:
1
Start:
94,148,988 bp from pter
End:
94,275,068 bp from pter
Size:
126,081 bases
Orientation:
Minus strand

Genomic View for ARHGAP29 Gene

Genes around ARHGAP29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP29 Gene

Proteins for ARHGAP29 Gene

  • Protein details for ARHGAP29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LW3-RHG29_HUMAN
    Recommended name:
    Rho GTPase-activating protein 29
    Protein Accession:
    Q52LW3
    Secondary Accessions:
    • O15463
    • Q59H86
    • Q5VYZ0
    • Q6NVX2
    • Q8TBI6

    Protein attributes for ARHGAP29 Gene

    Size:
    1261 amino acids
    Molecular mass:
    142064 Da
    Quaternary structure:
    • Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By similarity).
    SequenceCaution:
    • Sequence=AAH67839.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP29 Gene

Proteomics data for ARHGAP29 Gene at MOPED

Post-translational modifications for ARHGAP29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP29 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARHGAP29 Gene

Domains & Families for ARHGAP29 Gene

Gene Families for ARHGAP29 Gene

Protein Domains for ARHGAP29 Gene

Suggested Antigen Peptide Sequences for ARHGAP29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q52LW3

UniProtKB/Swiss-Prot:

RHG29_HUMAN :
  • Contains 1 F-BAR domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 Rho-GAP domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with ARHGAP29: view

Function for ARHGAP29 Gene

Molecular function for ARHGAP29 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated in mantle-cell lymphomas. Up-regulated in migrating glioma cells.

Gene Ontology (GO) - Molecular Function for ARHGAP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP29: view
genes like me logo Genes that share phenotypes with ARHGAP29: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP29 Gene

Localization for ARHGAP29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP29 Gene COMPARTMENTS Subcellular localization image for ARHGAP29 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP29 Gene

Pathways & Interactions for ARHGAP29 Gene

genes like me logo Genes that share pathways with ARHGAP29: view

Pathways by source for ARHGAP29 Gene

1 GeneTex pathway for ARHGAP29 Gene
3 Reactome pathways for ARHGAP29 Gene

Gene Ontology (GO) - Biological Process for ARHGAP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP29: view

No data available for SIGNOR curated interactions for ARHGAP29 Gene

Drugs & Compounds for ARHGAP29 Gene

(4) Additional Compounds for ARHGAP29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with ARHGAP29: view

Transcripts for ARHGAP29 Gene

Unigene Clusters for ARHGAP29 Gene

Rho GTPase activating protein 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP29 Gene

No ASD Table

Relevant External Links for ARHGAP29 Gene

GeneLoc Exon Structure for
ARHGAP29
ECgene alternative splicing isoforms for
ARHGAP29

Expression for ARHGAP29 Gene

mRNA expression in normal human tissues for ARHGAP29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP29 Gene

This gene is overexpressed in Esophagus (36.2), Breast (11.5), and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP29 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP29 Gene Hs.483238

mRNA Expression by UniProt/SwissProt for ARHGAP29 Gene

Q52LW3-RHG29_HUMAN
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney.
genes like me logo Genes that share expression patterns with ARHGAP29: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ARHGAP29 Gene

Orthologs for ARHGAP29 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP29 35
  • 99.55 (n)
  • 99.29 (a)
ARHGAP29 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP29 35
  • 87.15 (n)
  • 85.57 (a)
ARHGAP29 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP29 36
  • 87 (a)
OneToOne
ARHGAP29 35
  • 88.52 (n)
  • 87.14 (a)
mouse
(Mus musculus)
Mammalia Arhgap29 16
Arhgap29 35
  • 84.53 (n)
  • 83.36 (a)
Arhgap29 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP29 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap29 35
  • 83.48 (n)
  • 82.76 (a)
chicken
(Gallus gallus)
Aves ARHGAP29 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP29 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgap29a 36
  • 41 (a)
OneToMany
arhgap29b 36
  • 41 (a)
OneToMany
sbcb905 35
worm
(Caenorhabditis elegans)
Secernentea spv-1 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 36
  • 15 (a)
ManyToMany
RGA2 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for ARHGAP29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP29 Gene

ENSEMBL:
Gene Tree for ARHGAP29 (if available)
TreeFam:
Gene Tree for ARHGAP29 (if available)

Paralogs for ARHGAP29 Gene

Paralogs for ARHGAP29 Gene

(4) SIMAP similar genes for ARHGAP29 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP29: view

Variants for ARHGAP29 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP29 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_038552 A breast cancer sample
rs1999272 - 94,173,891(+) TTTCA(C/T)CTTCG reference, missense
rs11165091 - 94,174,080(+) TGCCA(A/G)GAGGC reference, missense
rs11196 -- 94,172,883(-) AAAAT(G/T)TATTT utr-variant-3-prime
rs1048846 -- 94,201,794(-) ATGAT(C/G)TAGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP29 Gene

Variant ID Type Subtype PubMed ID
dgv268n71 CNV Loss 21882294
nsv1888 CNV Insertion 18451855
nsv506947 CNV Insertion 20534489

Variation tolerance for ARHGAP29 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP29 Gene

HapMap Linkage Disequilibrium report
ARHGAP29
Human Gene Mutation Database (HGMD)
ARHGAP29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP29 Gene

Disorders for ARHGAP29 Gene

Relevant External Links for ARHGAP29

Genetic Association Database (GAD)
ARHGAP29
Human Genome Epidemiology (HuGE) Navigator
ARHGAP29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP29

No disorders were found for ARHGAP29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP29 Gene

Publications for ARHGAP29 Gene

  1. A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. (PMID: 9305890) Saras J. … Heldin C.-H. (J. Biol. Chem. 1997) 2 3 4 67
  2. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PMID: 15752761) Myagmar B.-E. … Kariya K. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation. (PMID: 25963656) Post A. … Bos J.L. (Mol. Cell. Biol. 2015) 3
  5. Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. (PMID: 25163644) Letra A. … Hecht J.T. (Birth Defects Res. Part A Clin. Mol. Teratol. 2014) 3

Products for ARHGAP29 Gene

Sources for ARHGAP29 Gene

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