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Aliases & Descriptions for ARHGAP29
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000012383 2 | | PARG1 1, 2, 3, 5 | | RP11-255E17.1 2 |
| | | Descriptions |
|---|
| PTPL1-associated RhoGAP 1 2 | | PTPL1-associated RhoGAP 1 (PARG1) 2 | | PTPL1-associated RhoGAP protein 1 3 | | Rho GTPase activating protein 29 2 | | Rho-type GTPase-activating protein 29 3 |
|
| | Search outside databases for aliases for ARHGAP29 gene |
Summaries for ARHGAP29(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho |
Genomic Location for ARHGAP29
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ARHGAP29 gene 
Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22.1ARHGAP29 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M094350:
(about GC identifiers)
Start:
|
94,407,051 bp from pter |
End:
|
94,475,895 bp from pter |
Size:
|
68,845 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for ARHGAP29
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 29 Size: 1261 amino acids; 142064 Da
Subunit: Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain
Sequence caution: Sequence=AAH67839.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: O15463 Q59H86 Q5VYZ0 Q6NVX2 Q8TBI6Alternative splicing: 2 isoforms: Q52LW3-1 Q52LW3-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004806.3
ENSEMBL proteins: ENSP00000260526 ENSP00000359237
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | About this table
Antibodies for ARHGAP29: Assays for ARHGAP29: | Protein
Domains/ Families for ARHGAP29(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q52LW3
ProtoNet protein and cluster: Q52LW3 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 Rho-GAP domain | Gene Function for ARHGAP29
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004815
Applied Biosystems Silencer® siRNAs for ARHGAP29
Sigma-Aldrich siRNA for ARHGAP29  Sigma-Aldrich shRNA for ARHGAP29  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004815                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004815                                  untagged cDNA clone in CMV expression vector: NM_004815 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004815
UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate RhoInduction: Strongly down-regulated in mantle-cell lymphomas. Up-regulated in migrating glioma cells5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ARHGAP29
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for ARHGAP29 (Q52LW32) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007242 | intracellular signaling cascade |
IEA | -- | | GO:0007266 | Rho protein signal transduction |
TAS | 9305890 | About this table
|
Drugs & Compounds for ARHGAP29(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ARHGAP29
|
Transcripts for ARHGAP29(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004815
Sigma-Aldrich siRNA for ARHGAP29  Sigma-Aldrich shRNA for ARHGAP29  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004815 REFSEQ mRNAs for ARHGAP29 gene: NM_004815.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004815               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004815                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004815                                  untagged cDNA clone in CMV expression vector: NM_004815  Additional cDNA sequence: AB208873.1 AK092668.1 AK307733.1 AK310491.1 BC022483.1 BC037337.2 BC067839.1 BC093741.1 BC093767.1 U90920.1 8 DOTS entries: DT.115774 DT.99938113 DT.97787439 DT.121377432 DT.121377438 DT.121377404 DT.40115116 DT.91730506 24/129 AceView cDNA sequences (see all 129
):T32506 AA233086 AI371814 NM_004815 AL049151 BQ876447 BG251121 BE464429 CA447050 AI830522 BU620659 BX100086 BM695915 T32345 AA330162 BX470473 AL046292 BX951729 BC067839 BE669766 BF434196 BX486936 BC022483 AA431928
highest scoring ESTs for ARHGAP29:U90920 AI368158 AL037674 BC022483 BC067839 BG709345 BI548487 AA127268 AA127269 AA131500 Unigene Cluster for ARHGAP29: Rho GTPase activating protein 29 Hs.483238 [show with all ESTs]Unigene Representative Sequence: NM_004815
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000260526
ENST00000370217
|
Expression for ARHGAP29
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ARHGAP29 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ARHGAP29
1 / 2 / 3 7 probe-sets matching ARHGAP29 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGATAGTCAG
SOURCE GeneReport for Unigene cluster: Hs.483238
Expression variation in blood from EXPOLDB for ARHGAP29 UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney |
Orthologs for ARHGAP29
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ARHGAP29 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ARHGAP29
ENSEMBL Gene Tree for ARHGAP29 | Paralogs for ARHGAP29(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ARHGAP29 gene
- HMHA12 RACGAP12 GMIP2
|
SNPs/Variants for ARHGAP29(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ARHGAP29 (up to first 250kb)
|
Disorders & Mutations for ARHGAP29
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610496
|
Medical News for ARHGAP29(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ARHGAP29 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for ARHGAP29 gene (see all 14
):- A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. (PubMed id 9305890)2, 3, 4 Saras J....Heldin C.H. (1997)
- PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PubMed id 15752761)1, 3, 4 Myagmar B.-E.... Kariya K. (2005)
- Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. (PubMed id 17488656)3, 4 Ripperger T....Steinemann D. (2007)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)4 Olsen J.V....Mann M. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)4 Gregory S.G.... Bentley D.R. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PubMed id 14749388)3 Jaffe A.B.... Hall A. (2004)
|
Search for ARHGAP29
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ARHGAP29
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ARHGAP29
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGAP29(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ARHGAP29(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ARHGAP29:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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