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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP29 Gene

protein-coding   GIFtS: 59
GCID: GC01M094634

Rho GTPase Activating Protein 29

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 291 2     RP11-255E17.12
PARG12 3 5     PTPL1-Associated RhoGAP 1 (PARG1)2
Rho-Type GTPase-Activating Protein 292 3     Rho GTPase-Activating Protein 292
PTPL1-Associated RhoGAP Protein 12 3     

External Ids:    HGNC: 302071   Entrez Gene: 94112   Ensembl: ENSG000001379627   OMIM: 6104965   UniProtKB: Q52LW33   

Export aliases for ARHGAP29 gene to outside databases

Previous GC identifers: GC01M094350 GC01M094407 GC01M092755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARHGAP29 Gene: 
ARHGAP29 (Rho GTPase activating protein 29) is a protein-coding gene. Diseases associated with ARHGAP29 include mantle cell lymphoma, and spasticity, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include Rho GTPase activator activity and metal ion binding. An important paralog of this gene is SYDE2.

UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong
activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to
regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in
endothelial cells and plays an essential role in blood vessel tubulogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP29 gene promoter:
         SRF   TBP   GATA-3   p53   SRF (504 AA)   FOXD3   C/EBPalpha   CHOP-10   PPAR-gamma2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP29 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP29

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p21.3   HGNC cytogenetic band: 1p22.1

ARHGAP29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP29 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094634:  view genomic region     (about GC identifiers)

Start:
94,614,544 bp from pter      End:
94,740,624 bp from pter
Size:
126,081 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 29  
Size: 1261 amino acids; 142064 Da
Subunit: Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By
similarity)
Sequence caution: Sequence=AAH67839.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: O15463 Q59H86 Q5VYZ0 Q6NVX2 Q8TBI6
Alternative splicing: 2 isoforms:  Q52LW3-1   Q52LW3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP29: NX_Q52LW3

Explore proteomics data for ARHGAP29 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q52LW3

  • ARHGAP29 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP29 Protein Expression
    REFSEQ proteins: NP_004806.3  
    ENSEMBL proteins: 
     ENSP00000449764   ENSP00000260526   ENSP00000359237  
    Reactome Protein details: Q52LW3
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    Cloud-Clone Corp. Proteins for ARHGAP29 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGAP29 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q52LW3

    ProtoNet protein and cluster: Q52LW3

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP29 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG29_HUMAN, Q52LW3
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong
    activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to
    regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in
    endothelial cells and plays an essential role in blood vessel tubulogenesis
    Induction: Strongly down-regulated in mantle-cell lymphomas. Up-regulated in migrating glioma cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity TAS9305890
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    ARHGAP29 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP29 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ARHGAP29
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP29 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP29

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for ARHGAP29 (Q52LW32, 3 ENSP000002605264) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129232, 3, ENSP000003947944MINT-8311002 MINT-8310989 I2D: score=2 STRING: ENSP00000394794
    MAGEA11P433642, 3, ENSP000003473584MINT-67052 I2D: score=5 STRING: ENSP00000347358
    SIRT1Q96EB63, ENSP000002120154I2D: score=2 STRING: ENSP00000212015
    RAP2AP101143, ENSP000002453044I2D: score=2 STRING: ENSP00000245304
    AKT1P317493, ENSP000002702024I2D: score=1 STRING: ENSP00000270202
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS9305890
    GO:0032321positive regulation of Rho GTPase activity TAS9305890
    GO:0035556intracellular signal transduction ----

    ARHGAP29 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP29 (RHG29)

    10/843 HMDB Compounds for ARHGAP29 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about ARHGAP29 / RHG29

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP29 gene: 
    NM_004815.3  

    Unigene Cluster for ARHGAP29:

    Rho GTPase activating protein 29
    Hs.483238  [show with all ESTs]
    Unigene Representative Sequence: NM_004815
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546444 ENST00000552844(uc009wdq.1) ENST00000260526(uc001dqj.4)
    ENST00000482481(uc001dqk.3) ENST00000370217(uc001dql.3)
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    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP29 (see all 85):
    hsa-miR-411* hsa-miR-520e hsa-miR-300 hsa-miR-485-3p hsa-miR-371-5p hsa-miR-519a hsa-miR-3916 hsa-miR-3162-5p
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    Additional mRNA sequence: 

    AB208873.1 AK092668.1 AK307733.1 AK310491.1 BC022483.1 BC037337.2 BC067839.1 BC093741.1 
    BC093767.1 U90920.1 

    8 DOTS entries:

    DT.115774  DT.99938113  DT.97787439  DT.121377432  DT.121377438  DT.121377404  DT.91730506  DT.40115116 

    24/129 AceView cDNA sequences (see all 129):

    BU620659 AA330162 AI371814 CA447050 BG251121 T32345 AA233086 BQ876447 
    BE464429 AI830522 T32506 AL049151 BM695915 BX100086 BX470473 NM_004815 
    BG251531 AI283106 BX486936 AW050655 BC022483 BE139616 BG612138 Z28520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP29 expression in normal human tissues (normalized intensities)      ARHGAP29 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATAGTCAG
    ARHGAP29 Expression
    About this image


    ARHGAP29 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood

    See ARHGAP29 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP29

    SOURCE GeneReport for Unigene cluster: Hs.483238

    UniProtKB/Swiss-Prot: RHG29_HUMAN, Q52LW3
    Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate
    level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP29

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP29 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap291 , 5 Rho GTPase activating protein 291, 5 84.39(n)1
    83.28(a)1
      3 (52.94 cM)5
    2141371  NM_172525.21  NP_766113.11 
     1219532295 
    chicken
    (Gallus gallus)
    Aves ARHGAP291 Rho GTPase activating protein 29 64.23(n)
    56.45(a)
      424488  NM_001244882.1  NP_001231811.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP296
    Rho GTPase activating protein 29
    48(a)
    1 ↔ 1
    4(88871326-88952004)
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb9052 sbcb905 73.86(n)   378998  BC059184.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3411 Protein TAG-341 46.32(n)
    31.42(a)
      174278  NM_063265.5  NP_495666.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BEM26
    Rho GTPase activating protein (RhoGAP) involved in...
    7(a)
    1 → many
    V(476345-482848)


    ENSEMBL Gene Tree for ARHGAP29 (if available)
    TreeFam Gene Tree for ARHGAP29 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP29 gene
    SYDE22  HMHA12  RACGAP12  ABR2  SYDE12  GMIP2  BCR2  
    4 SIMAP similar genes for ARHGAP29 using alignment to 2 protein entries:     RHG29_HUMAN (see all proteins):
    ARHGAP23    HMHA1    GMIP    ARHGAP12

    ARHGAP29 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1469 SNPs in ARHGAP29 are shown (see all 1469)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0385524
    A breast cancer sample4--see VAR_0385522 S C mis40--------
    rs1450052141,2
    C--94633994(+) GATCTC/TGGCTC 1 -- ds50010--------
    rs1887835791,2
    --94634027(+) TTCAAA/GCAATT 1 -- ds50010--------
    rs1808289011,2
    --94634030(+) AAGCAA/CTTCTC 1 -- ds50010--------
    rs1471442771,2
    C--94634082(+) TACTAC/TGCCTG 1 -- ds50010--------
    rs1405804121,2
    C--94634160(+) ACCTCA/GTGATC 1 -- ds50010--------
    rs1497459071,2
    --94634227(+) CCTGAC/TTTTTA 1 -- ds50010--------
    rs1861090811,2
    --94634282(+) GTAACA/GGTCAC 1 -- ds50010--------
    rs1177158921,2
    C,F--94634318(+) AACACT/CATAAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs115778651,2
    C,H--94634375(+) GAAATC/ATGAGA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for ARHGAP29 (94614544 - 94740624 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARHGAP29:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv506947CNV Insertion20534489
    nsv1888CNV Insertion18451855
    dgv268n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ARHGAP29
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610496    OMIM disorders: --

    3 diseases for ARHGAP29:    About MalaCards
    mantle cell lymphoma    spasticity    endotheliitis


    ARHGAP29 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP29
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP29 (1 document)

    Export disorders for ARHGAP29 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP29 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ARHGAP29)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. (PubMed id 9305890)1, 2, 3 Saras J....Heldin C.-H. (1997)
    2. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PubMed id 15752761)1, 2, 9 Myagmar B.-E.... Kariya K. (2005)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    4. Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. (PubMed id 17488656)1, 2 Ripperger T.... Steinemann D. (2007)
    5. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identif ied by genome-wide association on chromosome 1p22. (PubMed id 23008150)1 Leslie E.J....Murray J.C. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Genetic predictors of fibrin D-dimer levels in health y adults. (PubMed id 21502573)1 Smith N.L....Hayward C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9411 HGNC: 30207 AceView: PARG1 Ensembl:ENSG00000137962 euGenes: HUgn9411
    ECgene: ARHGAP29 H-InvDB: ARHGAP29

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP29 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP29 gene:
    Search GeneIP for patents involving ARHGAP29

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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