Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP28 Gene

Aliases for ARHGAP28 Gene

  • Rho GTPase Activating Protein 28 2 3 5
  • Rho-Type GTPase-Activating Protein 28 4
  • KIAA1314 4

External Ids for ARHGAP28 Gene

Previous GeneCards Identifiers for ARHGAP28 Gene

  • GC18P006781
  • GC18U900243

Summaries for ARHGAP28 Gene

GeneCards Summary for ARHGAP28 Gene

ARHGAP28 (Rho GTPase Activating Protein 28) is a Protein Coding gene. Diseases associated with ARHGAP28 include Substance Dependence and Migraine With Or Without Aura 1. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP28 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP28 Gene

Genomics for ARHGAP28 Gene

Regulatory Elements for ARHGAP28 Gene

Enhancers for ARHGAP28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP28 Gene

6,729,718 bp from pter
6,915,716 bp from pter
185,999 bases
Plus strand

Genomic View for ARHGAP28 Gene

Genes around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP28 Gene

Proteins for ARHGAP28 Gene

  • Protein details for ARHGAP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 28
    Protein Accession:
    Secondary Accessions:
    • A8MQB7
    • A8MU88
    • Q6P160
    • Q8N4T3
    • Q9NW53

    Protein attributes for ARHGAP28 Gene

    729 amino acids
    Molecular mass:
    82060 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91533.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP28 Gene


neXtProt entry for ARHGAP28 Gene

Proteomics data for ARHGAP28 Gene at MOPED

Post-translational modifications for ARHGAP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP28 Gene

Domains & Families for ARHGAP28 Gene

Gene Families for ARHGAP28 Gene

Protein Domains for ARHGAP28 Gene

Suggested Antigen Peptide Sequences for ARHGAP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP28: view

Function for ARHGAP28 Gene

Molecular function for ARHGAP28 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
genes like me logo Genes that share phenotypes with ARHGAP28: view

Animal Models for ARHGAP28 Gene

MGI Knock Outs for ARHGAP28:

Animal Model Products

CRISPR Products

miRNA for ARHGAP28 Gene

miRTarBase miRNAs that target ARHGAP28

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP28 Gene

Localization for ARHGAP28 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP28 Gene COMPARTMENTS Subcellular localization image for ARHGAP28 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP28 Gene

Pathways & Interactions for ARHGAP28 Gene

genes like me logo Genes that share pathways with ARHGAP28: view

Pathways by source for ARHGAP28 Gene

3 Reactome pathways for ARHGAP28 Gene

Interacting Proteins for ARHGAP28 Gene

Gene Ontology (GO) - Biological Process for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for SIGNOR curated interactions for ARHGAP28 Gene

Drugs & Compounds for ARHGAP28 Gene

No Compound Related Data Available

Transcripts for ARHGAP28 Gene

mRNA/cDNA for ARHGAP28 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP28 Gene

Rho GTPase activating protein 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP28 Gene

No ASD Table

Relevant External Links for ARHGAP28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP28 Gene

mRNA expression in normal human tissues for ARHGAP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP28 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for ARHGAP28 Gene

This gene is overexpressed in Stomach (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP28 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP28 Gene Hs.183114

mRNA Expression by UniProt/SwissProt for ARHGAP28 Gene

Tissue specificity: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle.
genes like me logo Genes that share expression patterns with ARHGAP28: view

Primer Products

No data available for Protein tissue co-expression partners for ARHGAP28 Gene

Orthologs for ARHGAP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP28 35
  • 86.82 (n)
  • 84.71 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ARHGAP28 35
  • 89.63 (n)
  • 90.16 (a)
  • 69 (a)
(Mus musculus)
Mammalia Arhgap28 35
  • 83.42 (n)
  • 85.13 (a)
Arhgap28 16
Arhgap28 36
  • 66 (a)
(Pan troglodytes)
Mammalia ARHGAP28 35
  • 99.55 (n)
  • 99.23 (a)
  • 72 (a)
(Rattus norvegicus)
Mammalia Arhgap28 35
  • 84.13 (n)
  • 85.66 (a)
(Monodelphis domestica)
Mammalia ARHGAP28 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP28 36
  • 45 (a)
(Gallus gallus)
Aves ARHGAP28 35
  • 67.15 (n)
  • 59.75 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia ARHGAP28 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap28 35
  • 64.78 (n)
  • 59 (a)
(Danio rerio)
Actinopterygii arhgap28 35
  • 54.88 (n)
  • 48.47 (a)
arhgap28 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ARHGAP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP28 Gene

Gene Tree for ARHGAP28 (if available)
Gene Tree for ARHGAP28 (if available)

Paralogs for ARHGAP28 Gene

genes like me logo Genes that share paralogs with ARHGAP28: view

Variants for ARHGAP28 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP28 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs6506448 - 6,851,059(+) CCACA(C/G)TAATC reference, missense
rs1056408 - 6,912,144(-) AACTT(G/T)GTTGG reference, missense
rs2303978 - 6,837,373(-) CCTGA(C/T)AGATT reference, missense
rs14478 -- 6,915,400(-) CAGAG(A/G)AACTA utr-variant-3-prime
rs16735 -- 6,915,544(-) GAAAA(-/TAGT)TGGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP28 Gene

Variant ID Type Subtype PubMed ID
esv34611 CNV Gain 17911159
dgv1009e1 CNV Complex 17122850
nsv9604 CNV Loss 18304495
esv271900 CNV Insertion 20981092
nsv833583 CNV Gain 17160897
nsv909336 CNV Gain 21882294
esv27738 CNV Gain 19812545
nsv909337 CNV Loss 21882294
nsv132229 CNV Insertion 16902084
esv2673830 CNV Deletion 23128226
nsv9605 CNV Loss 18304495

Variation tolerance for ARHGAP28 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP28 Gene

Disorders for ARHGAP28 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARHGAP28 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
substance dependence
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP28

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGAP28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP28 Gene

Publications for ARHGAP28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Association of substance dependence phenotypes in the COGA sample. (PMID: 24832863) Wetherill L. … Foroud T. (Addict Biol 2014) 3
  3. Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. (PMID: 25211221) Yeung C.Y. … Kadler K.E. (PLoS ONE 2014) 3
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for ARHGAP28 Gene

Sources for ARHGAP28 Gene