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Aliases for ARHGAP28 Gene

Aliases for ARHGAP28 Gene

  • Rho GTPase Activating Protein 28 2 3
  • KIAA1314 4 6
  • Rho-Type GTPase-Activating Protein 28 4

External Ids for ARHGAP28 Gene

Previous GeneCards Identifiers for ARHGAP28 Gene

  • GC18P006781
  • GC18U900243

Summaries for ARHGAP28 Gene

GeneCards Summary for ARHGAP28 Gene

ARHGAP28 (Rho GTPase Activating Protein 28) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP28 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP28 Gene

Genomics for ARHGAP28 Gene

Regulatory Elements for ARHGAP28 Gene

Genomic Location for ARHGAP28 Gene

6,729,718 bp from pter
6,915,716 bp from pter
185,999 bases
Plus strand

Genomic View for ARHGAP28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP28 Gene

Proteins for ARHGAP28 Gene

  • Protein details for ARHGAP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 28
    Protein Accession:
    Secondary Accessions:
    • A8MQB7
    • A8MU88
    • Q6P160
    • Q8N4T3
    • Q9NW53

    Protein attributes for ARHGAP28 Gene

    729 amino acids
    Molecular mass:
    82060 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91533.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP28 Gene


neXtProt entry for ARHGAP28 Gene

Proteomics data for ARHGAP28 Gene at MOPED

Post-translational modifications for ARHGAP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP28 Gene

Domains for ARHGAP28 Gene

Gene Families for ARHGAP28 Gene

  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP28 Gene

Suggested Antigen Peptide Sequences for ARHGAP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P2N2
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP28: view

Function for ARHGAP28 Gene

Molecular function for ARHGAP28 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP28: view
genes like me logo Genes that share phenotypes with ARHGAP28: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP28 Gene

miRTarBase miRNAs that target ARHGAP28

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP28 Gene

Localization for ARHGAP28 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP28 Gene COMPARTMENTS Subcellular localization image for ARHGAP28 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Pathways for ARHGAP28 Gene

genes like me logo Genes that share pathways with ARHGAP28: view

Pathways by source for ARHGAP28 Gene

3 Reactome pathways for ARHGAP28 Gene

Interacting Proteins for ARHGAP28 Gene

Gene Ontology (GO) - Biological Process for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view

Transcripts for ARHGAP28 Gene

mRNA/cDNA for ARHGAP28 Gene

(9) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP28 Gene

Rho GTPase activating protein 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP28

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP28 Gene

No ASD Table

Relevant External Links for ARHGAP28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP28 Gene

mRNA expression in normal human tissues for ARHGAP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP28 Gene

This gene is overexpressed in Testis (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP28 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP28 Gene Hs.183114

mRNA Expression by UniProt/SwissProt for ARHGAP28 Gene

Tissue specificity: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle.
genes like me logo Genes that share expressions with ARHGAP28: view

In Situ Assay Products

Orthologs for ARHGAP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP28 35
  • 99.55 (n)
  • 99.23 (a)
  • 72 (a)
(Bos Taurus)
Mammalia ARHGAP28 35
  • 86.82 (n)
  • 84.71 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ARHGAP28 35
  • 89.63 (n)
  • 90.16 (a)
  • 69 (a)
(Mus musculus)
Mammalia Arhgap28 35
  • 83.42 (n)
  • 85.13 (a)
Arhgap28 16
Arhgap28 36
  • 66 (a)
(Monodelphis domestica)
Mammalia ARHGAP28 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP28 36
  • 45 (a)
(Rattus norvegicus)
Mammalia Arhgap28 35
  • 84.13 (n)
  • 85.66 (a)
(Gallus gallus)
Aves ARHGAP28 35
  • 67.15 (n)
  • 59.75 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia ARHGAP28 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap28 35
  • 64.78 (n)
  • 59 (a)
(Danio rerio)
Actinopterygii arhgap28 35
  • 54.88 (n)
  • 48.47 (a)
arhgap28 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ARHGAP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP28 Gene

Gene Tree for ARHGAP28 (if available)
Gene Tree for ARHGAP28 (if available)

Paralogs for ARHGAP28 Gene

genes like me logo Genes that share paralogs with ARHGAP28: view

Variants for ARHGAP28 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP28 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs14478 -- 6,915,400(-) CAGAG(A/G)AACTA utr-variant-3-prime
rs16735 -- 6,915,544(-) GAAAA(-/TAGT)TGGTA utr-variant-3-prime
rs472541 -- 6,884,171(+) agatc(A/G)agact intron-variant
rs485069 -- 6,908,438(-) GTCAC(A/G)gccgg intron-variant
rs488370 -- 6,877,193(-) CTCTC(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP28 Gene

Variant ID Type Subtype PubMed ID
esv34611 CNV Gain 17911159
dgv1009e1 CNV Complex 17122850
nsv9604 CNV Loss 18304495
esv271900 CNV Insertion 20981092
nsv833583 CNV Gain 17160897
nsv909336 CNV Gain 21882294
esv27738 CNV Gain 19812545
nsv909337 CNV Loss 21882294
nsv132229 CNV Insertion 16902084
esv2673830 CNV Deletion 23128226
nsv9605 CNV Loss 18304495

Relevant External Links for ARHGAP28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Disorders for ARHGAP28 Gene

(1) University of Copenhagen DISEASES for ARHGAP28 Gene

Relevant External Links for ARHGAP28

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ARHGAP28: view

No data available for UniProtKB/Swiss-Prot for ARHGAP28 Gene

Publications for ARHGAP28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ARHGAP28 Gene

Sources for ARHGAP28 Gene

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