Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGAP28 Gene

protein-coding GIFtS: 49
GCID: GC18P006730

Rho GTPase activating protein 28

Explore 2 diseases affiliated with
ARHGAP28 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 28¹ ²
KIAA1314¹ ³ ⁵
Rho-Type GTPase-Activating Protein 28² ³
FLJ10312¹
Rho GTPase-Activating Protein 28²

External Ids:	HGNC: 25509¹	Entrez Gene: 79822²	Ensembl: ENSG00000088756⁷	OMIM: 610592⁵	UniProtKB: Q9P2N2³

Export aliases for ARHGAP28 gene to outside databases

Previous GC identifers: GC18P006781 GC18U900243

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHG28_HUMAN, Q9P2N2

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGAP28 gene promoter:
TBP STAT5B AML1a STAT5A Nkx2-5 NF-AT FOXC1 POU2F1 POU2F1a NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP28 promoter sequence

Search SABiosciences Chromatin IP Primers for ARHGAP28

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP28

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.23

ARHGAP28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP28 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P006730: view genomic region (about GC identifiers)

Start:	6,729,717 bp from pter	End:	6,915,715 bp from pter
Size:	185,999 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG28_HUMAN, Q9P2N2 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 28

Size: 729 amino acids; 82060 Da

Sequence caution: Sequence=BAA91533.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA92552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A8MQB7 A8MU88 Q6P160 Q8N4T3 Q9NW53

Alternative splicing: 4 isoforms: Q9P2N2-1 Q9P2N2-2 Q9P2N2-3 Q9P2N2-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP28: NX_Q9P2N2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2N2

ARHGAP28 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001010000.1

ENSEMBL proteins:

ENSP00000372964 ENSP00000464141 ENSP00000462831 ENSP00000433390 ENSP00000262227

ENSP00000462912 ENSP00000392660 ENSP00000437262 ENSP00000464310 ENSP00000463672

ENSP00000435990 ENSP00000463143 ENSP00000382963 ENSP00000313506 ENSP00000406907

Reactome Protein details: Q9P2N2
Human Recombinant Protein Products for ARHGAP28:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): ARHGAP28 OriGene Custom Protein Services for ARHGAP28
	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP28
	Novus Biologicals ARHGAP28 Protein Novus Biologicals ARHGAP28 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ARHGAP28

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005829	cytosol	TAS	--

ARHGAP28 for ontologies About GeneDecksing

ARHGAP28 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ARHGAP28
	GenScript Custom Superior Antibodies Services for ARHGAP28
	Novus Biologicals ARHGAP28 Antibodies
	Abcam antibodies for ARHGAP28
	Uscn Antibodies for ARHGAP28
	Search ThermoFisher Antibodies for ARHGAP28

Assay Products for ARHGAP28:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ARHGAP28
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ARHGAP28

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP28 for domains About GeneDecksing

2 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q9P2N2

ProtoNet protein and cluster: Q9P2N2

1 Blocks protein family: IPB000198 RhoGAP domain

UniProtKB/Swiss-Prot: RHG28_HUMAN, Q9P2N2

Similarity: Contains 1 Rho-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHG28_HUMAN, Q9P2N2

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--

ARHGAP28 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ARHGAP28:

Downregulation of NF-kappaB pa

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARHGAP28

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ARHGAP28 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP28
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP28 (see all 25):
		hsa-miR-579 hsa-miR-875-3p hsa-let-7d hsa-miR-202 hsa-miR-767-5p hsa-let-7c hsa-miR-507 hsa-let-7g

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP28 (see all 3) OriGene siRNA: ARHGAP28
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP28
		Sirion Biotech Custom design and validation of potent shRNA sequences against ARHGAP28

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ARHGAP28
			Sirion Biotech Customized adenovirus for overexpression of ARHGAP28 Sirion Biotech Customized adenovirus for potent knockdown of ARHGAP28

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARHGAP28 (NM_001010000)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP28
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP28

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARHGAP28
		Search LifeMap BioReagents cell lines for ARHGAP28
		Sirion Biotech Customized stable knockdown cell line services for ARHGAP28 Sirion Biotech Customized inducible knockdown cell line services for ARHGAP28 Sirion Biotech Customized stable overexpressing cell line services for ARHGAP28 Sirion Biotech Customized inducible overexpressing cell line services for ARHGAP28

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP28

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ARHGAP28

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

ARHGAP28 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP28

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

ARHGAP28 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGAP28
Search CenterWatch for drugs/clinical trials and news about ARHGAP28 / RHG28

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARHGAP28 gene (2 alternative transcripts):

NM_030672.2 NM_001010000.2

Unigene Cluster for ARHGAP28:

Rho GTPase activating protein 28

Hs.183114 [show with all ESTs]

Unigene Representative Sequence: NM_001010000

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000383472 ENST00000583410 ENST00000584387 ENST00000532723 ENST00000262227(uc002knc.3)

ENST00000581099 ENST00000419673(uc002kne.3 uc010wzi.2) ENST00000531294

ENST00000584287 ENST00000577524 ENST00000532996(uc002knf.3) ENST00000579689

ENST00000579245 ENST00000579796 ENST00000400091 ENST00000314319 ENST00000418986

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ARHGAP28 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP28
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP28 (see all 25):
		hsa-miR-579 hsa-miR-875-3p hsa-let-7d hsa-miR-202 hsa-miR-767-5p hsa-let-7c hsa-miR-507 hsa-let-7g

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP28 (see all 3) OriGene siRNA: ARHGAP28
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP28
		Sirion Biotech Custom design and validation of potent shRNA sequences against ARHGAP28

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARHGAP28 (NM_001010000)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP28
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP28

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARHGAP28
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP28
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP28

Additional cDNA sequence:

AB037735.1 AK001174.1 AK024298.1 AK289791.1 AK302026.1 AK308259.1 BC033668.1 BC065274.1

BX648684.1

10 DOTS entries:

DT.410248 DT.100728701 DT.100022141 DT.92419891 DT.121087962 DT.101969868 DT.121087973 DT.65284146

DT.75115625 DT.95268365

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGAP28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTAGAAA

About this image

ARHGAP28 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See ARHGAP28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP28

SOURCE GeneReport for Unigene cluster: Hs.183114

UniProtKB/Swiss-Prot: RHG28_HUMAN, Q9P2N2

Tissue specificity: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in

spleen and skeletal muscle

SABiosciences Custom PCR Arrays for ARHGAP28

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARHGAP28
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP28
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP28

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP28

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP28 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARHGAP28¹	Rho GTPase activating protein 28	67.15(n) 59.75(a)		421053 XM_419140.3 XP_419140.3
lizard (Anolis carolinensis)	Reptilia	ARHGAP28⁶	--	43(a)	1 ↔ 1	GL343431.1(13045-41019)
zebrafish (Danio rerio)	Actinopterygii	arhgap28¹	Rho GTPase activating protein 28	54.88(n) 48.47(a)		492794 NM_001007435.1 NP_001007436.1
fruit fly (Drosophila melanogaster)	Insecta	CG17082⁶	--	12(a)	1 → many	2R(631836-645548)

ENSEMBL Gene Tree for ARHGAP28 (if available)
TreeFam Gene Tree for ARHGAP28 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGAP28 gene

ARHGAP36² ARHGAP6² STARD13² ARHGAP40² ARHGAP18² ARHGAP11A² DLC1² ARHGAP11B²

STARD8²

5 SIMAP similar genes for ARHGAP28 using alignment to 10 protein entries: RHG28_HUMAN (see all proteins):

ARHGAP18 ARHGAP40 FAM13B ARHGAP12 FAM13A

ARHGAP28 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73382798^1,2	C	--	6832471(+)	`TTGATT/ATAACA`	1	--	us2k¹		1		WA	2
rs183647607^1,2		--	6832607(+)	`ATTGTC/TACTCC`	1	--	us2k¹		0	--	--	--	--
rs144997170^1,2		--	6832611(+)	`TTACTC/GCTTGT`	1	--	us2k¹		0	--	--	--	--
rs116531330^1,2	F	--	6832765(+)	`TATTTC/TATCCA`	1	--	us2k¹		1		WA	118
rs971529^1,2	C,F,A,H	--	6832779(-)	`AGGTAG/AAGAGT`	1	--	us2k¹		113		NS EA NA PA EU CA WA CSA	6922
rs971528^1,2	C,F,H	--	6832832(-)	`GAAATG/ATAAGC`	1	--	us2k¹		91		NS EA NA PA EU CA WA CSA	4593
rs202003600^1,2		--	6833067(+)	`TTGCT-/TTAAG TTGTC`	1	--	us2k¹		0	--	--	--	--
rs77575609^1,2	C	--	6833140(+)	`GTACAA/GTTTTA`	1	--	us2k¹		0	--	--	--	--
rs190246515^1,2		--	6833197(+)	`TCTATC/TACTCC`	1	--	us2k¹		0	--	--	--	--
rs148677140^1,2		--	6833263(+)	`CCATTC/TGCTGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARHGAP28 (6729717 - 6915715 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ARHGAP28
4 CNVs: 8855 88706 32200 4050
2 Indels: 73098 33657

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP28

DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP28

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARHGAP28 for disorders           About GeneDecksing

OMIM gene information: 610592    OMIM disorders: --

2 diseases for ARHGAP28:    About MalaCards

benign meningioma meningioma

1 disease from the University of Copenhagen DISEASES database for ARHGAP28:

Benign meningioma

Export disorders for ARHGAP28 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARHGAP28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGAP28)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)^{1, 2} Nusbaum C.... Lander E.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79822	HGNC: 25509	Ensembl:ENSG00000088756	euGenes: HUgn79822	ECgene: ARHGAP28
H-InvDB: ARHGAP28

(According to HUGE)
About This Section

HUGE: KIAA1314

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARHGAP28	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARHGAP28 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARHGAP28 gene:
Search GeneIP for patents involving ARHGAP28

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP28		Browse OriGene genome-wide validated SYBR primer pairs
	OriGene Protein Over-expression Lysate for ARHGAP28		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ARHGAP28		OriGene 3'-UTR Clone for ARHGAP28
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP28
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ARHGAP28		OriGene Custom Protein Services for ARHGAP28
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP28
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP28
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP28
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP28
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP28
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP28

	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP28		GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP28
	GenScript Custom Assay Services for ARHGAP28		GenScript Custom Superior Antibodies Services for ARHGAP28
	GenScript Custom overexpressing Cell Line Services for ARHGAP28		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ARHGAP28 promoter
	Search Chromatin IP Primers for ARHGAP28
	RT² qPCR Primer Assay in human, mouse, rat ARHGAP28
	Search GNC Networks for ARHGAP28
	SABiosciences Custom PCR Arrays for ARHGAP28

Search Tocris compounds for ARHGAP28

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ARHGAP28 antibodies
	ARHGAP28 proteins
	ARHGAP28 lysates

	Antibodies for ARHGAP28
	See all of Abcam's Antibodies, Kits and Proteins for ARHGAP28
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ARHGAP28 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ARHGAP28

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP28

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ARHGAP28
	SwitchGear Promoter luciferase reporter plasmids for ARHGAP28

Search ThermoFisher Antibodies for ARHGAP28

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP28

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARHGAP28

Sirion Biotech Customized:

	stable knockdown cell line services for ARHGAP28
	inducible knockdown cell line services for ARHGAP28
	design and validation of potent shRNA sequences against ARHGAP28
	adenovirus for potent knockdown of ARHGAP28
	adenovirus for overexpression of ARHGAP28
	stable overexpressing cell line services for ARHGAP28
	inducible overexpressing cell line services for ARHGAP28

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARHGAP28 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ARHGAP28 Gene

Rho GTPase activating protein 28

Aliases
for ARHGAP28 gene

Summaries
for ARHGAP28 gene

Genomic Views
for ARHGAP28 gene

Proteins
for ARHGAP28 gene

Protein Domains /
Families
for ARHGAP28 gene

Function
for ARHGAP28 gene

Pathways & Interactions
for ARHGAP28 gene

Drugs & Compounds
for ARHGAP28 gene

Transcripts
for ARHGAP28 gene

Expression
for ARHGAP28 gene

Orthologs
for ARHGAP28 gene

Paralogs
for ARHGAP28 gene

Genomic Variants
for ARHGAP28 gene

Disorders / Diseases
for ARHGAP28 gene

Publications
for ARHGAP28 gene

External Searches for ARHGAP28 gene

Genome Databases showing ARHGAP28 gene

Other Databases showing ARHGAP28 gene

Specialized Databases showing ARHGAP28 gene

Intellectual Property
for ARHGAP28 gene

Products
for ARHGAP28 gene

View Random Gene

Advanced Search

Export list of displayed genes

ARHGAP28 Gene

Rho GTPase activating protein 28

Aliasesfor ARHGAP28 gene

Summariesfor ARHGAP28 gene

Genomic Viewsfor ARHGAP28 gene

Proteinsfor ARHGAP28 gene

Protein Domains /Familiesfor ARHGAP28 gene

Functionfor ARHGAP28 gene

Pathways & Interactionsfor ARHGAP28 gene

Drugs & Compoundsfor ARHGAP28 gene

Transcriptsfor ARHGAP28 gene

Expression for ARHGAP28 gene

Orthologsfor ARHGAP28 gene

Paralogsfor ARHGAP28 gene

Genomic Variantsfor ARHGAP28 gene

Disorders / Diseasesfor ARHGAP28 gene

Publicationsfor ARHGAP28 gene

External Searches for ARHGAP28 gene

Genome Databases showing ARHGAP28 gene

Other Databases showing ARHGAP28 gene

Specialized Databases showing ARHGAP28 gene

Intellectual Propertyfor ARHGAP28 gene

Productsfor ARHGAP28 gene

View Random Gene

Aliases
for ARHGAP28 gene

Summaries
for ARHGAP28 gene

Genomic Views
for ARHGAP28 gene

Proteins
for ARHGAP28 gene

Protein Domains /
Families
for ARHGAP28 gene

Function
for ARHGAP28 gene

Pathways & Interactions
for ARHGAP28 gene

Drugs & Compounds
for ARHGAP28 gene

Transcripts
for ARHGAP28 gene

Expression
for ARHGAP28 gene

Orthologs
for ARHGAP28 gene

Paralogs
for ARHGAP28 gene

Genomic Variants
for ARHGAP28 gene

Disorders / Diseases
for ARHGAP28 gene

Publications
for ARHGAP28 gene

Intellectual Property
for ARHGAP28 gene

Products
for ARHGAP28 gene