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ARHGAP27 Gene

protein-coding   GIFtS: 51
GCID: GC17M043538

Rho GTPase Activating Protein 27

(Previous name: SH3 domain containing 20)
(Previous symbol: SH3D20)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 271 2     CIN85-Associated Multi-Domain-Containing Rho GTPase-Activating Protein 12 3
SH3D201 2 3     SH3 Domain-Containing Protein 202 3
CAMGAP12 3 5     PP9052
SH3 Domain Containing 201 2     SH3P202
Rho-Type GTPase-Activating Protein 272 3     Rho GTPase-Activating Protein 272

External Ids:    HGNC: 318131   Entrez Gene: 2011762   Ensembl: ENSG000001593147   OMIM: 6105915   UniProtKB: Q6ZUM43   

Export aliases for ARHGAP27 gene to outside databases

Previous GC identifers: GC17M040827 GC17M043475 GC17M043476 GC17M043488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP27 Gene:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP)
metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for ARHGAP27 Gene:
ARHGAP27 (Rho GTPase activating protein 27) is a protein-coding gene. GO annotations related to this gene include Rac GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG27_HUMAN, Q6ZUM4
Function: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators
for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and
RAC1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NT_167251.2  NT_187663.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP27 gene promoter:
         RP58   AML1a   HTF   IRF-1   XBP-1   YY1   AREB6   HEN1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP27 promoter sequence
   Search Chromatin IP Primers for ARHGAP27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

ARHGAP27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP27 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M043538:  view genomic region     (about GC identifiers)

Start:
43,471,268 bp from pter      End:
43,511,787 bp from pter
Size:
40,520 bases      Orientation:
minus strand

2 alternative locations:
Chr17-,ALT_REF_LOCI_9 43,471,268-43,510,270      Chr17-,NT_167251 86,404-125,407     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHG27_HUMAN, Q6ZUM4 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 27  
Size: 889 amino acids; 98396 Da
Subunit: Interacts with SH3KBP1/CIN85 (By similarity)
Caution: According to HGNC, ARHGAP27 and SH3D20 are 2 separate genes, corresponding to isoform 2 and isoform 4,
respectively. However, a rat transcript and paralog proteins with a similar domain structure suggest the
existence of a single gene encoding for a protein of 889 residues as displayed here
Sequence caution: Sequence=AAI01389.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI01390.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI01391.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ARHGAP27:
3PP2 (3D)    
Secondary accessions: A4FU35 A8K3N5 C9JTF3 Q494U0 Q6NWZ8 Q8WY58
Alternative splicing: 4 isoforms:  Q6ZUM4-1   Q6ZUM4-2   Q6ZUM4-3   Q6ZUM4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP27: NX_Q6ZUM4

Explore proteomics data for ARHGAP27 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys551
  • Modification sites at PhosphoSitePlus

  • See ARHGAP27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269219.1  NP_777579.2  NP_954976.1  

    ENSEMBL proteins: 
     ENSP00000432762   ENSP00000366121   ENSP00000431591   ENSP00000433942   ENSP00000431722  
     ENSP00000437100   ENSP00000436137   ENSP00000403323   ENSP00000409330   ENSP00000408235  
     ENSP00000290470  

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    antibodies-online peptides for ARHGAP27

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    Selected InterPro protein domains (see all 8):
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR015767 Rho_GTPase_activating

    Graphical View of Domain Structure for InterPro Entry Q6ZUM4

    ProtoNet protein and cluster: Q6ZUM4

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG27_HUMAN, Q6ZUM4
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 3 WW domains


    Find genes that share domains with ARHGAP27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG27_HUMAN, Q6ZUM4
    Function: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators
    for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and
    RAC1 (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding ISS--
    GO:0030675Rac GTPase activator activity ISS--
         
    Find genes that share ontologies with ARHGAP27           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGAP27:
     Cells with protrusions 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARHGAP27

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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP27 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG27_HUMAN, Q6ZUM4: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ISS--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with ARHGAP27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP27
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP27 (Q6ZUM43 ENSP000003661214) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B973, ENSP000003809214I2D: score=2 STRING: ENSP00000380921
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=1 STRING: ENSP00000348461
    NIFKENSP000002858144STRING: ENSP00000285814
    RALBP1ENSP000000193174STRING: ENSP00000019317
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis ISS--
    GO:0007165signal transduction IEA--
    GO:0032855positive regulation of Rac GTPase activity ISS--
    GO:0043089positive regulation of Cdc42 GTPase activity ISS--

    Find genes that share ontologies with ARHGAP27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGAP27 (RHG27)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP27 gene (4 alternative transcripts): 
    NM_001159330.1  NM_001282290.1  NM_174919.3  NM_199282.2  

    Unigene Cluster for ARHGAP27:

    Rho GTPase activating protein 27
    Hs.205326  [show with all ESTs]
    Unigene Representative Sequence: NM_199282
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000532038 ENST00000376922(uc010dak.3 uc002iix.3) ENST00000531735
    ENST00000528384 ENST00000590026 ENST00000581991 ENST00000532891 ENST00000581638
    ENST00000582826 ENST00000529357(uc010wjl.1) ENST00000526484 ENST00000524404
    ENST00000532667 ENST00000528677 ENST00000527678 ENST00000579357(uc002iiy.1)
    ENST00000528273(uc010dal.3) ENST00000428638
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    Additional mRNA sequence: 

    AF258593.1 AK125535.1 AK290650.1 BC029634.1 BC067345.1 BC101388.1 BC101389.1 BC101390.1 
    BC101391.2 

    17 DOTS entries:

    DT.91696393  DT.95158550  DT.65286419  DT.100788398  DT.97840893  DT.99935846  DT.95072486  DT.80101552 
    DT.101968166  DT.120983519  DT.313548  DT.95072491  DT.75103564  DT.91744395  DT.92037882  DT.92423130 
    DT.95072483 

    Selected AceView cDNA sequences (see all 267):

    AA836034 AI346000 AI281677 AI419637 AA480883 BQ018860 BE675781 CA436224 
    AA229703 AA748338 Z39380 BX281644 AI380337 AI344040 BF001901 AA477529 
    BE646342 BQ706531 AI222571 BX279931 CD365191 BF062445 BF064115 BE676198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGCCTGC
    ARHGAP27 Expression
    About this image

    ARHGAP27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.205326

    UniProtKB/Swiss-Prot: RHG27_HUMAN, Q6ZUM4
    Tissue specificity: Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer
    and lung cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP27 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap271 , 5 Rho GTPase activating protein 271, 5 83.58(n)1
    84.59(a)1
      11 (67.02 cM)5
    5448171  NM_001205236.11  NP_001192165.11 
     1033314975 
    chicken
    (Gallus gallus)
    Aves ARHGAP271 Rho GTPase activating protein 27 67.74(n)
    62.16(a)
      770740  XM_003642784.2  XP_003642832.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP276
    Rho GTPase activating protein 27
    36(a)
    1 ↔ 1
    6(63201901-63260151)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152742 Xenopus laevis transcribed sequence with weak similarity more 77.3(n)    BG407355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5665231 rho GTPase-activating protein 27-like 54.36(n)
    48.15(a)
      566523  XM_005171602.1  XP_005171659.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3256
    Protein TAG-325 (tag-325) mRNA, complete cds
    18(a)
    1 → many
    III(4796841-4802910) WBGene00008006


    ENSEMBL Gene Tree for ARHGAP27 (if available)
    TreeFam Gene Tree for ARHGAP27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP27 gene
    ARHGAP212  ARHGAP102  CHN22  ARHGAP232  ARHGAP92  CHN12  ARHGAP262  ARHGAP152  
    ARHGAP122  OPHN12  ARHGAP422  
    12 SIMAP similar genes for ARHGAP27 using alignment to 6 protein entries:     RHG27_HUMAN (see all proteins):
    OPHN1    ARHGAP15    CHN1    ARHGAP5    ARHGAP12    ARHGAP21
    CHN2    ARHGAP24    ARHGAP31    ARHGAP9    BCR/ABL fusion    FAM13A

    Find genes that share paralogs with ARHGAP27           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ARHGAP27
    PGOHUM00000237497 PGOHUM00000262603


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP27 (see all 776)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141008981,2
    F--43470825(+) AATGAG/AAGGGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1506613311,2
    --43470928(+) ACCTGA/CCCTTT 1 -- int10--------
    rs29054541,2
    C,H--43470935(+) CTTTAG/AAACAT 1 -- int16Minor allele frequency- A:0.00NS EA NA 414
    rs1174970161,2
    C,F--43470972(+) GCCCCG/ACCCAA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1399040611,2
    --43471113(+) CTGCTC/TGGGGG 1 -- int10--------
    rs1897055941,2
    C--43471154(+) GGAAGG/TCTGAG 1 -- int10--------
    rs1808871911,2
    --43471157(+) AGGCTA/GAGCCC 1 -- int10--------
    rs1853480931,2
    C--43471218(+) TCAAAG/TAAGTT 1 -- int10--------
    rs76131,2
    C,F,A--43471481(+) CACCTG/AGCACA 1 -- ut3113Minor allele frequency- A:0.32MN NA WA CSA EA 743
    rs47631,2
    C,F--43471489(-) TGCTCC/TTCTGT 1 -- ut317Minor allele frequency- T:0.29MN NA 868

    HapMap Linkage Disequilibrium report for ARHGAP27 (43471268 - 43511787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP27 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676260CNV Deletion23128226
    esv1009543CNV Insertion20482838
    dgv123e55CNV Loss17911159
    esv22600CNV Loss19812545
    nsv908304CNV Loss21882294
    nsv9562CNV Gain18304495
    nsv428342CNV Gain18775914
    esv627CNV CNV17122850
    dgv965e1CNV Complex17122850
    nsv511056CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP27
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610591    OMIM disorders: --


    Find genes that share disorders with ARHGAP27           About GenesLikeMe


    Export disorders for ARHGAP27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP27 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ARHGAP27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of ARHGAP27 gene in silico. (PubMed id 15492870)1, 2, 9 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2004)
    2. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. (PubMed id 15147912)1, 3 Sakakibara T....Takeshima H. (FEBS Lett. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. (PubMed id 20070850)1 Edwards T.L....Martin E.R. (Ann. Hum. Genet. 2010)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. (PubMed id 12297274)1 Peck J....Burbelo P.D. (FEBS Lett. 2002)
    10. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (Mol. Vis. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201176 HGNC: 31813 AceView: ARHGAP27 Ensembl:ENSG00000159314 euGenes: HUgn201176
    ECgene: ARHGAP27 H-InvDB: ARHGAP27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP27 gene:
    Search GeneIP for patents involving ARHGAP27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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