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Aliases for ARHGAP27 Gene

Aliases for ARHGAP27 Gene

  • Rho GTPase Activating Protein 27 2 3 5
  • CIN85-Associated Multi-Domain-Containing Rho GTPase-Activating Protein 1 3 4
  • Rho-Type GTPase-Activating Protein 27 3 4
  • SH3 Domain-Containing Protein 20 3 4
  • SH3 Domain Containing 20 2 3
  • CAMGAP1 3 4
  • SH3D20 3 4
  • Rho GTPase-Activating Protein 27 3
  • SH3P20 3
  • PP905 3

External Ids for ARHGAP27 Gene

Previous HGNC Symbols for ARHGAP27 Gene

  • SH3D20

Previous GeneCards Identifiers for ARHGAP27 Gene

  • GC17M040827
  • GC17M043475
  • GC17M043476
  • GC17M043488
  • GC17M043538

Summaries for ARHGAP27 Gene

Entrez Gene Summary for ARHGAP27 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for ARHGAP27 Gene

ARHGAP27 (Rho GTPase Activating Protein 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP12.

UniProtKB/Swiss-Prot for ARHGAP27 Gene

  • Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP27 Gene

Genomics for ARHGAP27 Gene

Regulatory Elements for ARHGAP27 Gene

Enhancers for ARHGAP27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G045404 2 FANTOM5 Ensembl ENCODE dbSUPER 26.1 +23.6 23619 13.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LINC02210 LRRC37A4P ARHGAP27 FMNL1 SPATA32 ENSG00000262372 GJC1 KANSL1 EFTUD2 LRRC37A
GH17G045305 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +120.7 120690 17.2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 FMNL1 LINC02210 SPATA32 ARHGAP27 GPATCH8 DCAKD LRRC37A4P PLEKHM1 DND1P1 MAPK8IP1P1
GH17G045392 1.5 Ensembl ENCODE dbSUPER 12.5 +39.4 39386 4.1 HDGF PKNOX1 ATF1 CREB3L1 ARNT ARID4B ZNF2 ZNF48 TCF12 ZNF143 LINC02210 ARHGAP27 LRRC37A4P MAP3K14 FMNL1 SPATA32 ENSG00000224505 HEXIM2 ENSG00000262539 ENSG00000267344
GH17G045401 1 dbSUPER 13.9 +31.9 31887 1.5 FOXA2 ATF1 MLX ARID4B YY1 SP5 NFYC MXD4 MIER2 PPARG LINC02210 ARHGAP27 FMNL1 SPATA32 GC17M045407 ENSG00000267344
GH17G045423 1.5 Ensembl ENCODE dbSUPER 9 +9.5 9474 3.1 SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF121 GLIS2 ZNF143 FOS KLF7 LINC02210 ARHGAP27 ENSG00000131484 GC17M045407
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP27 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP27 Gene

Chromosome:
17
Start:
45,393,902 bp from pter
End:
45,434,421 bp from pter
Size:
40,520 bases
Orientation:
Minus strand

Genomic View for ARHGAP27 Gene

Genes around ARHGAP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP27 Gene

Proteins for ARHGAP27 Gene

  • Protein details for ARHGAP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUM4-RHG27_HUMAN
    Recommended name:
    Rho GTPase-activating protein 27
    Protein Accession:
    Q6ZUM4
    Secondary Accessions:
    • A4FU35
    • A8K3N5
    • C9JTF3
    • Q494U0
    • Q6NWZ8
    • Q8WY58

    Protein attributes for ARHGAP27 Gene

    Size:
    889 amino acids
    Molecular mass:
    98396 Da
    Quaternary structure:
    • Interacts with SH3KBP1/CIN85.
    SequenceCaution:
    • Sequence=AAI01389.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01390.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01391.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP27 Gene

    Alternative splice isoforms for ARHGAP27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP27 Gene

Post-translational modifications for ARHGAP27 Gene

  • Ubiquitination at posLast=551551
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP27 Gene

Domains & Families for ARHGAP27 Gene

Suggested Antigen Peptide Sequences for ARHGAP27 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP27: view

No data available for UniProtKB/Swiss-Prot for ARHGAP27 Gene

Function for ARHGAP27 Gene

Molecular function for ARHGAP27 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0017124 SH3 domain binding ISS --
genes like me logo Genes that share ontologies with ARHGAP27: view
genes like me logo Genes that share phenotypes with ARHGAP27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP27 Gene

Localization for ARHGAP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP27 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP27 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ARHGAP27: view

Pathways & Interactions for ARHGAP27 Gene

genes like me logo Genes that share pathways with ARHGAP27: view

Pathways by source for ARHGAP27 Gene

3 Reactome pathways for ARHGAP27 Gene

Gene Ontology (GO) - Biological Process for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis ISS --
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with ARHGAP27: view

No data available for SIGNOR curated interactions for ARHGAP27 Gene

Drugs & Compounds for ARHGAP27 Gene

No Compound Related Data Available

Transcripts for ARHGAP27 Gene

Unigene Clusters for ARHGAP27 Gene

Rho GTPase activating protein 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP27 Gene

No ASD Table

Relevant External Links for ARHGAP27 Gene

GeneLoc Exon Structure for
ARHGAP27
ECgene alternative splicing isoforms for
ARHGAP27

Expression for ARHGAP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP27 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP27 Gene

This gene is overexpressed in Whole Blood (x11.5) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for ARHGAP27 Gene

This gene is overexpressed in Heart (25.4), Cervix (16.1), and Lymph node (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP27 Gene



Protein tissue co-expression partners for ARHGAP27 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP27 Gene:

ARHGAP27

SOURCE GeneReport for Unigene cluster for ARHGAP27 Gene:

Hs.205326

mRNA Expression by UniProt/SwissProt for ARHGAP27 Gene:

Q6ZUM4-RHG27_HUMAN
Tissue specificity: Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer.

Evidence on tissue expression from TISSUES for ARHGAP27 Gene

  • Pancreas(4.1)
  • Liver(4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ARHGAP27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP27 Gene

Orthologs for ARHGAP27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP27 34 35
  • 99.64 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap27 34
  • 83.7 (n)
mouse
(Mus musculus)
Mammalia Arhgap27 34 16 35
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 76 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ARHGAP27 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP27 34 35
  • 67.74 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP27 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap27 34
  • 58.31 (n)
Str.11931 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15274 34
zebrafish
(Danio rerio)
Actinopterygii LOC566523 34
  • 54.36 (n)
arhgap27l 35
  • 27 (a)
OneToMany
arhgap27 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-325 35
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for ARHGAP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP27 Gene

ENSEMBL:
Gene Tree for ARHGAP27 (if available)
TreeFam:
Gene Tree for ARHGAP27 (if available)

Paralogs for ARHGAP27 Gene

Pseudogenes.org Pseudogenes for ARHGAP27 Gene

genes like me logo Genes that share paralogs with ARHGAP27: view

Variants for ARHGAP27 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000058743 -- 45,406,425(+) CATTC(C/T)GGAAA intron-variant
rs1000187656 -- 45,403,778(+) CCTAC(C/T)CCAGG intron-variant
rs1000323868 -- 45,408,818(+) GGCCC(A/G)ATGGC intron-variant
rs1000596159 -- 45,423,208(+) AATAC(A/G)CATTT intron-variant
rs1000634956 -- 45,416,363(+) GCTGA(A/C)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP27 Gene

Variant ID Type Subtype PubMed ID
dgv123e55 CNV loss 17911159
dgv1472n106 CNV deletion 24896259
esv1009543 CNV insertion 20482838
esv22600 CNV loss 19812545
esv2676260 CNV deletion 23128226
esv2758691 CNV gain+loss 17122850
esv3640663 CNV loss 21293372
esv3640664 CNV loss 21293372
nsv1070831 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv428342 CNV gain 18775914
nsv511056 OTHER complex 20534489
nsv575103 CNV loss 21841781
nsv9562 CNV gain 18304495

Variation tolerance for ARHGAP27 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP27 Gene

Disorders for ARHGAP27 Gene

Relevant External Links for ARHGAP27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP27

No disorders were found for ARHGAP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP27 Gene

Publications for ARHGAP27 Gene

  1. Identification and characterization of ARHGAP27 gene in silico. (PMID: 15492870) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2004) 3 4 22 64
  2. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. (PMID: 15147912) Sakakibara T. … Takeshima H. (FEBS Lett. 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. (PMID: 20070850) Edwards T.L. … Martin E.R. (Ann. Hum. Genet. 2010) 3 64

Products for ARHGAP27 Gene

Sources for ARHGAP27 Gene

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