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Aliases for ARHGAP27 Gene

Aliases for ARHGAP27 Gene

  • Rho GTPase Activating Protein 27 2 3 5
  • CIN85-Associated Multi-Domain-Containing Rho GTPase-Activating Protein 1 3 4
  • Rho-Type GTPase-Activating Protein 27 3 4
  • SH3 Domain-Containing Protein 20 3 4
  • SH3 Domain Containing 20 2 3
  • CAMGAP1 3 4
  • SH3D20 3 4
  • SH3P20 3
  • PP905 3

External Ids for ARHGAP27 Gene

Previous HGNC Symbols for ARHGAP27 Gene

  • SH3D20

Previous GeneCards Identifiers for ARHGAP27 Gene

  • GC17M040827
  • GC17M043475
  • GC17M043476
  • GC17M043488
  • GC17M043538

Summaries for ARHGAP27 Gene

Entrez Gene Summary for ARHGAP27 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for ARHGAP27 Gene

ARHGAP27 (Rho GTPase Activating Protein 27) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP9.

UniProtKB/Swiss-Prot for ARHGAP27 Gene

  • Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP27 Gene

Genomics for ARHGAP27 Gene

Regulatory Elements for ARHGAP27 Gene

Genomic Location for ARHGAP27 Gene

Chromosome:
17
Start:
45,393,902 bp from pter
End:
45,434,421 bp from pter
Size:
40,520 bases
Orientation:
Minus strand

Genomic View for ARHGAP27 Gene

Genes around ARHGAP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP27 Gene

Proteins for ARHGAP27 Gene

  • Protein details for ARHGAP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUM4-RHG27_HUMAN
    Recommended name:
    Rho GTPase-activating protein 27
    Protein Accession:
    Q6ZUM4
    Secondary Accessions:
    • A4FU35
    • A8K3N5
    • C9JTF3
    • Q494U0
    • Q6NWZ8
    • Q8WY58

    Protein attributes for ARHGAP27 Gene

    Size:
    889 amino acids
    Molecular mass:
    98396 Da
    Quaternary structure:
    • Interacts with SH3KBP1/CIN85.
    SequenceCaution:
    • Sequence=AAI01389.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01390.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI01391.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP27 Gene

    Alternative splice isoforms for ARHGAP27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP27 Gene

Proteomics data for ARHGAP27 Gene at MOPED

Post-translational modifications for ARHGAP27 Gene

  • Ubiquitination at Lys 551
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ARHGAP27 Gene

Domains & Families for ARHGAP27 Gene

Suggested Antigen Peptide Sequences for ARHGAP27 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZUM4

UniProtKB/Swiss-Prot:

RHG27_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
  • Contains 3 WW domains.
genes like me logo Genes that share domains with ARHGAP27: view

Function for ARHGAP27 Gene

Molecular function for ARHGAP27 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
genes like me logo Genes that share ontologies with ARHGAP27: view
genes like me logo Genes that share phenotypes with ARHGAP27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP27 Gene

Localization for ARHGAP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP27 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP27 Gene COMPARTMENTS Subcellular localization image for ARHGAP27 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ARHGAP27: view

Pathways & Interactions for ARHGAP27 Gene

SuperPathways for ARHGAP27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARHGAP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis ISS --
genes like me logo Genes that share ontologies with ARHGAP27: view

No data available for Pathways by source and SIGNOR curated interactions for ARHGAP27 Gene

Drugs & Compounds for ARHGAP27 Gene

No Compound Related Data Available

Transcripts for ARHGAP27 Gene

Unigene Clusters for ARHGAP27 Gene

Rho GTPase activating protein 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP27 Gene

No ASD Table

Relevant External Links for ARHGAP27 Gene

GeneLoc Exon Structure for
ARHGAP27
ECgene alternative splicing isoforms for
ARHGAP27

Expression for ARHGAP27 Gene

mRNA expression in normal human tissues for ARHGAP27 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP27 Gene

This gene is overexpressed in Whole Blood (x11.5) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for ARHGAP27 Gene

This gene is overexpressed in Heart (25.4), Cervix (16.1), and Lymph node (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP27 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP27 Gene Hs.205326

mRNA Expression by UniProt/SwissProt for ARHGAP27 Gene

Q6ZUM4-RHG27_HUMAN
Tissue specificity: Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer.
genes like me logo Genes that share expression patterns with ARHGAP27: view

Protein tissue co-expression partners for ARHGAP27 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGAP27 Gene

Orthologs for ARHGAP27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP27 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Arhgap27 35
  • 83.58 (n)
  • 84.59 (a)
Arhgap27 16
Arhgap27 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP27 35
  • 99.64 (n)
  • 99.82 (a)
ARHGAP27 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap27 35
  • 83.7 (n)
  • 84.47 (a)
cow
(Bos Taurus)
Mammalia ARHGAP27 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 22 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP27 35
  • 67.74 (n)
  • 62.16 (a)
ARHGAP27 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP27 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap27 35
  • 58.31 (n)
  • 53.56 (a)
Str.11931 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15274 35
zebrafish
(Danio rerio)
Actinopterygii LOC566523 35
  • 54.36 (n)
  • 48.15 (a)
arhgap27 36
  • 26 (a)
OneToMany
arhgap27l 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-325 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for ARHGAP27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP27 Gene

ENSEMBL:
Gene Tree for ARHGAP27 (if available)
TreeFam:
Gene Tree for ARHGAP27 (if available)

Paralogs for ARHGAP27 Gene

Pseudogenes.org Pseudogenes for ARHGAP27 Gene

genes like me logo Genes that share paralogs with ARHGAP27: view

Variants for ARHGAP27 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_038551 -
rs4763 -- 45,394,123(-) TGCTC(C/T)TCTGT utr-variant-3-prime
rs7613 -- 45,394,115(+) CACCT(A/G)GCACA utr-variant-3-prime
rs8327 -- 45,395,141(-) GTTTG(C/T)TTTCT downstream-variant-500B, utr-variant-3-prime
rs1058264 -- 45,430,250(-) GTGTA(A/C/T)GTGCT nc-transcript-variant, reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP27 Gene

Variant ID Type Subtype PubMed ID
nsv428342 CNV Gain 18775914
dgv964e1 CNV Complex 17122850
esv627 CNV CNV 17122850
nsv511056 CNV Complex 20534489
dgv965e1 CNV Complex 17122850
nsv908304 CNV Loss 21882294
dgv123e55 CNV Loss 17911159
esv2676260 CNV Deletion 23128226
esv22600 CNV Loss 19812545
esv1009543 CNV Insertion 20482838
nsv9562 CNV Gain 18304495

Variation tolerance for ARHGAP27 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP27 Gene

HapMap Linkage Disequilibrium report
ARHGAP27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP27 Gene

Disorders for ARHGAP27 Gene

Relevant External Links for ARHGAP27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP27

No disorders were found for ARHGAP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP27 Gene

Publications for ARHGAP27 Gene

  1. Identification and characterization of ARHGAP27 gene in silico. (PMID: 15492870) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2004) 3 4 23 67
  2. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. (PMID: 15147912) Sakakibara T. … Takeshima H. (FEBS Lett. 2004) 2 3
  3. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. (PMID: 20070850) Edwards T.L. … Martin E.R. (Ann. Hum. Genet. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3

Products for ARHGAP27 Gene

Sources for ARHGAP27 Gene

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