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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGAP26 Gene

protein-coding GIFtS: 63
GCID: GC05P142130

Rho GTPase activating protein 26

Explore 13 diseases affiliated with
ARHGAP26 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 26¹ ²		GRAF1²
GRAF¹ ² ³ ⁵		GTPase Regulator Associated With Focal Adhesion Kinase Pp125(FAK)²
OPHN1L¹ ² ³		Rho GTPase-Activating Protein 26²
OPHN1L1¹ ²		GTPase Regulator Associated With Focal Adhesion Kinase³
KIAA0621¹ ³		Rho-Type GTPase-Activating Protein 26³
Oligophrenin-1-Like Protein² ³

External Ids:	HGNC: 17073¹	Entrez Gene: 23092²	Ensembl: ENSG00000145819⁷	OMIM: 605370⁵	UniProtKB: Q9UNA1³

Export aliases for ARHGAP26 gene to outside databases

Previous GC identifers: GC05P142179 GC05P137297

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP26:

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling

cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is

focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion

kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of

juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: RHG26_HUMAN, Q9UNA1

Function: GTPase-activating protein for RHOA and CDC42

Gene Wiki entry for ARHGAP26

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGAP26 gene promoter:
TBP AhR MEF-2 Lmo2 POU6F1 (c2) GATA-1 Arnt Gfi-1 aMEF-2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP26 promoter sequence

Search SABiosciences Chromatin IP Primers for ARHGAP26

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP26

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31

ARHGAP26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP26 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P142130: view genomic region (about GC identifiers)

Start:	142,149,949 bp from pter	End:	142,608,576 bp from pter
Size:	458,628 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG26_HUMAN, Q9UNA1 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 26

Size: 814 amino acids; 92235 Da

Subunit: Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1

Subcellular location: Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity).

Note=Colocalizes with actin stress fibers and cortical actin structures (By similarity)

1 PDB 3D structure from and Proteopedia for ARHGAP26:

1UGV (3D)

Secondary accessions: O75117 Q5D035 Q9BYS6 Q9BYS7 Q9UJ00

Alternative splicing: 2 isoforms: Q9UNA1-1 Q9UNA1-2

Explore the universe of human proteins at neXtProt for ARHGAP26: NX_Q9UNA1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UNA1

ARHGAP26 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001129080.1 NP_055886.1

ENSEMBL proteins:

ENSP00000274498 ENSP00000367243 ENSP00000367252 ENSP00000411571 ENSP00000393276

ENSP00000416889 ENSP00000392186 ENSP00000413283 ENSP00000400565 ENSP00000389137

ENSP00000403388

Reactome Protein details: Q9UNA1
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	Uscn Proteins for ARHGAP26

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005925	focal adhesion	IEA	--

ARHGAP26 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP26 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

IPR001452 SH3_domain

IPR011993 PH_like_dom

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q9UNA1

ProtoNet protein and cluster: Q9UNA1

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB001452 SH3 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: RHG26_HUMAN, Q9UNA1

Similarity: Contains 1 PH domain

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RHG26_HUMAN, Q9UNA1

Function: GTPase-activating protein for RHOA and CDC42

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ARHGAP26 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP26

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005100	Rho GTPase activator activity	NAS	10908648
GO:0005515	protein binding	IPI	11432776
GO:0005543	phospholipid binding	IEA	--
GO:0008093	cytoskeletal adaptor activity	IEA	--
GO:0017124	SH3 domain binding	IEA	--

ARHGAP26 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for ARHGAP26:

Decreased focal adhesion (FA)

Decreased viability with TRAIL

Gemcitabine induced cell-death

Weaker migration

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_RhoA regulation pathway

G-protein signaling RhoA regulation pathway

1.00

G-protein signaling_RhoA regulation pathway

1.00

Cell death signalling via NRAGE, NRIF and NADE

Rho GTPase cycle

0.25

Signaling by Rho GTPases

0.25

Neuroscience

Neuroscience

1.00

Signaling events mediated by focal adhesion kinase

Signaling events mediated by focal adhesion kinase

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ARHGAP26

G-protein signaling RhoA regulation pathway

1 Cell Signaling Technology (CST) Pathway for ARHGAP26

Neuroscience

1 GeneGo (Thomson Reuters) Pathway for ARHGAP26

G-protein signaling RhoA regulation pathway

1 BioSystems Pathway for ARHGAP26

Signaling events mediated by focal adhesion kinase

3 Reactome Pathways for ARHGAP26

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

ARHGAP26 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP26

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for ARHGAP26 (Q9UNA1^{1, 2, 3} ENSP00000274498⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PKN3	Q6P5Z2¹^,³, ENSP00000291906⁴	EBI-1390913,EBI-1384335 I2D: score=3 STRING: ENSP00000291906
PTEN	P60484³, ENSP00000361021⁴	I2D: score=1 STRING: ENSP00000361021
RHOA	P61586³, ENSP00000400175⁴	I2D: score=1 STRING: ENSP00000400175
INSR	P06213³, ENSP00000303830⁴	I2D: score=1 STRING: ENSP00000303830
CDC42	P60953³, ENSP00000314458⁴	I2D: score=1 STRING: ENSP00000314458

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007399	nervous system development	NAS	9582072
GO:0030036	actin cytoskeleton organization	NAS	11998687
GO:0032321	positive regulation of Rho GTPase activity	NAS	10908648

ARHGAP26 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGAP26
Search CenterWatch for drugs/clinical trials and news about ARHGAP26 / RHG26

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARHGAP26 gene (2 alternative transcripts):

NM_001135608.1 NM_015071.4

Unigene Cluster for ARHGAP26:

Rho GTPase activating protein 26

Hs.654668 [show with all ESTs]

Unigene Representative Sequence: NM_015071

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000274498 ENST00000378004(uc011dbj.2 uc003lmt.3 uc003lmw.3)

ENST00000378013 ENST00000475287 ENST00000477867 ENST00000451259 ENST00000461314

ENST00000469131 ENST00000469396 ENST00000464838 ENST00000470032 ENST00000443674

ENST00000418236 ENST00000443045 ENST00000419676 ENST00000424007 ENST00000489924

ENST00000486650

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		hsa-miR-194* hsa-miR-26a-2* hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-605 hsa-miR-138-2* hsa-miR-409-5p

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Additional cDNA sequence:

AB014521.1 AK092488.1 AK095220.1 AK123519.1 AK124521.1 AK298708.1 BC021059.2 BC068555.1

EF212277.1 EF212278.1 HM037040.1

20 DOTS entries:

DT.104754 DT.455437 DT.100764412 DT.100665202 DT.100750024 DT.95313595 DT.120804595 DT.95153992

DT.40312858 DT.91922143 DT.204298 DT.434059 DT.92012339 DT.95168500 DT.100664198 DT.100750023

DT.92041598 DT.95346706 DT.40273232 DT.70103744

24/264 AceView cDNA sequences (see all 264):

BX360448 CF456114 BX496040 BF085236 AW083421 AA427375 AI032890 BG000990

CB851536 CR610690 BF933322 AI862123 BM680705 BE276273 AA327733 BX391985

AI248411 BQ011885 BQ710410 AA514631 AW236944 AL600533 BM981023 BE326327

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP26 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b	·
SP1:																							-		-				-		-
SP2:																									-						-
SP3:
SP4:

ExUns:	23c	^	24
SP1:	-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ARHGAP26

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGAP26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTTGGTTT

About this image

ARHGAP26 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Lumbar Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARHGAP26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP26

SOURCE GeneReport for Unigene cluster: Hs.654668

SABiosciences Custom PCR Arrays for ARHGAP26

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP26 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Arhgap26^{1 , 5}	Rho GTPase activating protein 26^{1, 5}	90.95(n)¹ 96.93(a)¹		18 (20.51 cM)⁵ 71302¹ NM_175164.4¹ NP_780373.3¹ 38601534⁵
chicken (Gallus gallus)	Aves	ARHGAP26¹	Rho GTPase activating protein 26	81.09(n) 91.31(a)		396113 NM_205194.1 NP_990525.1
lizard (Anolis carolinensis)	Reptilia	ARHGAP26⁶	--	90(a)	1 ↔ 1	2(126369587-126583358)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX775324.1²	--	73.95(n)		BX775324.1
fruit fly (Drosophila melanogaster)	Insecta	Graf¹	CG8948-PA	51.73(n) 45.1(a)		32522 NM_132842.2 NP_573070.2
worm (Caenorhabditis elegans)	Secernentea	T04C9.1¹	Protein T04C9.1	53.7(n) 47.27(a)		175849 NM_171143.6 NP_741163.2

ENSEMBL Gene Tree for ARHGAP26 (if available)
TreeFam Gene Tree for ARHGAP26 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGAP26 gene

HMHA1² ARHGAP21² ARHGAP27² ARHGAP10² CHN2² ARHGAP23² ARHGAP9² ARHGAP29²

CHN1² ARHGAP15² ARHGAP12² OPHN1² GMIP² ARHGAP42²

14 SIMAP similar genes for ARHGAP26 using alignment to 11 protein entries: RHG26_HUMAN (see all proteins):

GRAF OPHN1 CHN2 SH3GL2 ARHGAP42 CHN1

ARHGAP12 ARHGAP10 ARHGEF7 ARHGAP21 DKFZp667D142 SH3GL1

ARHGAP9 FLJ20896

ARHGAP26 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ARHGAP26
PGOHUM00000242637

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76894761^1,2		--	137295885(+)	`CCCAAA/GATGGT`	2	--	us2k¹		0	--	--	--	--
rs59232070^1,2		--	137296103(+)	`TTTGCA/TTCCAT`	2	--	us2k¹		0	--	--	--	--
rs79893397^1,2	F,	--	137296190(+)	`ACATAG/ACAGAC`	2	--	us2k¹		1		EA	120
rs57666289^1,2		--	137296920(+)	`AAATCA/G/TGTTGC`	2	--	us2k¹		0	--	--	--	--
rs2276993^1,2	C,F,	--	137297595(-)	`TGTGGC/TGCTGG`	2	--	us2k¹ ese³		1		EA	930
rs2276991^1,2	H	--	137297925(-)	`CACCTC/GCCAGT`	2	--	int¹		5		EA NS	1906
rs76001141^1,2		--	137297990(+)	`GGGGAC/TGGGTG`	2	--	int¹		0	--	--	--	--
rs79522923^1,2	F,	--	137298067(+)	`GACCCG/ATCGCT`	2	--	int¹		1		WA	118
rs74894836^1,2	C,	--	137298276(+)	`AGTGCC/ACAACC`	2	--	int¹		4		CSA WA NA EA	360
rs74719160^1,2	F,	--	137298435(+)	`GAGTAT/CTGGCA`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ARHGAP26 (142149949 - 142399949 bp, first 250kb of ARHGAP26)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ARHGAP26
4 CNVs: 93270 81065 93269 64325
1 Indel: 93271

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARHGAP26 for disorders           About GeneDecksing

OMIM gene information: 605370
OMIM disorders: 607785
UniProtKB/Swiss-Prot: RHG26_HUMAN, Q9UNA1

Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric

myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and

2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient

13 diseases for ARHGAP26: About MalaCards

juvenile myelomonocytic leukemia myelomonocytic leukemia alpha-thalassemia/mental retardation syndrome leukemia

alpha thalassemia mental retardation syndrome thalassemia spondylolisthesis

cerebellar ataxia acute myeloid leukemia myeloid leukemia myelodysplastic syndrome

ataxia

Human Genome Epidemiology (HuGE) Navigator: ARHGAP26 (1 document)

Export disorders for ARHGAP26 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARHGAP26 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with ARHGAP26)

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. (PubMed id 10908648)^{1, 2, 9} Borkhardt A.... Lampert F. (2000)
Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. (PubMed id 9858476)^{1, 3} Taylor J.M....Parsons J.T. (1999)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. (PubMed id 8649427)^{1, 3} Hildebrand J.D....Parsons J.T. (1996)
Skeletal muscle differentiation and fusion are regula ted by the BAR-containing Rho-GTPase-activating Protein (Rho-GAP), GRAF1. (PubMed id 21622574)¹ Doherty J.T....Taylor J.M. (2011)
The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading. (PubMed id 21965292)¹ Doherty G.J....Lundmark R. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Abnormal methylation of GRAF promoter Chinese patient s with acute myeloid leukemia. (PubMed id 21074269)¹ Qian J....Wang Y.L. (2011)
GTPase regulator associated with the focal adhesion k inase (GRAF) transcript was down-regulated in patients with myeloid malignancie s. (PubMed id 20704716)¹ Qian Z....Li J.Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23092	HGNC: 17073	AceView: ARHGAP26	Ensembl:ENSG00000145819	euGenes: HUgn23092
ECgene: ARHGAP26	H-InvDB: ARHGAP26

(According to HUGE)
About This Section

HUGE: KIAA0621

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARHGAP26	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ARHGAP26	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Graf1

Intellectual Property for ARHGAP26 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ARHGAP26 gene:
Search GeneIP for patents involving ARHGAP26

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ARHGAP26 Gene

Rho GTPase activating protein 26

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ARHGAP26 Gene

Rho GTPase activating protein 26

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