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Aliases for ARHGAP26 Gene

Aliases for ARHGAP26 Gene

  • Rho GTPase Activating Protein 26 2 3 5
  • Oligophrenin-1-Like Protein 3 4
  • OPHN1L 3 4
  • GRAF 3 4
  • GTPase Regulator Associated With Focal Adhesion Kinase Pp125(FAK) 3
  • GTPase Regulator Associated With The Focal Adhesion Kinase Pp125 2
  • GTPase Regulator Associated With Focal Adhesion Kinase 4
  • Rho-Type GTPase-Activating Protein 26 4
  • Rho GTPase-Activating Protein 26 3
  • KIAA0621 4
  • OPHN1L1 3
  • GRAF1 3

External Ids for ARHGAP26 Gene

Previous GeneCards Identifiers for ARHGAP26 Gene

  • GC05P142179
  • GC05P142130
  • GC05P137297

Summaries for ARHGAP26 Gene

Entrez Gene Summary for ARHGAP26 Gene

  • Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ARHGAP26 Gene

ARHGAP26 (Rho GTPase Activating Protein 26) is a Protein Coding gene. Diseases associated with ARHGAP26 include Leukemia, Acute Myelomonocytic, Somatic, Somatic and Myelodysplastic Syndrome. Among its related pathways are Neuroscience and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP10.

UniProtKB/Swiss-Prot for ARHGAP26 Gene

  • GTPase-activating protein for RHOA and CDC42.

Gene Wiki entry for ARHGAP26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP26 Gene

Genomics for ARHGAP26 Gene

Regulatory Elements for ARHGAP26 Gene

Enhancers for ARHGAP26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F143117 1.2 FANTOM5 Ensembl ENCODE 36.4 +348.5 348521 2.2 TBP CTCF DMAP1 FEZF1 BCL11B ZNF48 SCRT2 SCRT1 YY2 OVOL3 ARHGAP26 NR3C1 ARHGAP26-IT1 GC05M142946
GH05F143124 1.7 FANTOM5 Ensembl ENCODE 29.1 +354.4 354421 0.8 FEZF1 GATA2 ZNF263 REST MEF2D SMARCA4 ZSCAN16 GLIS1 MYNN HMBOX1 ARHGAP26 NR3C1 ARHGAP26-IT1 GC05M142946
GH05F143007 1.2 FANTOM5 Ensembl ENCODE 28.1 +239.7 239709 4.2 PKNOX1 ARID4B YBX1 FEZF1 ZNF207 FOS SP5 JUNB TBX21 PPARG ARHGAP26 NR3C1 GC05M142946 ARHGAP26-IT1
GH05F142794 1.6 FANTOM5 Ensembl ENCODE 25.1 +29.5 29493 11.3 SIN3A RAD21 ZSCAN9 ZNF121 CREM CEBPB NR2F2 SREBF1 SP1 SMARCA4 ARHGAP26 ARHGAP26-AS1 GC05P142826 GC05P142827
GH05F143001 1.5 FANTOM5 Ensembl ENCODE 15.1 +233.8 233821 6.4 TBP PKNOX1 TBL1XR1 WRNIP1 RAD21 CBX5 ZNF143 FOS RCOR1 CREM NR3C1 ARHGAP26 GC05M142946 ARHGAP26-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGAP26 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001414656 521 3400 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5

Genomic Location for ARHGAP26 Gene

142,770,380 bp from pter
143,229,011 bp from pter
458,632 bases
Plus strand

Genomic View for ARHGAP26 Gene

Genes around ARHGAP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP26 Gene

Proteins for ARHGAP26 Gene

  • Protein details for ARHGAP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 26
    Protein Accession:
    Secondary Accessions:
    • O75117
    • Q5D035
    • Q9BYS6
    • Q9BYS7
    • Q9UJ00

    Protein attributes for ARHGAP26 Gene

    814 amino acids
    Molecular mass:
    92235 Da
    Quaternary structure:
    • Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for ARHGAP26 Gene

    Alternative splice isoforms for ARHGAP26 Gene


neXtProt entry for ARHGAP26 Gene

Post-translational modifications for ARHGAP26 Gene

  • Ubiquitination at Lys 454
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP26 Gene

Domains & Families for ARHGAP26 Gene

Gene Families for ARHGAP26 Gene

Suggested Antigen Peptide Sequences for ARHGAP26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP26: view

Function for ARHGAP26 Gene

Molecular function for ARHGAP26 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RHOA and CDC42.

Gene Ontology (GO) - Molecular Function for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 11432776
GO:0005543 phospholipid binding IDA 18954304
genes like me logo Genes that share ontologies with ARHGAP26: view
genes like me logo Genes that share phenotypes with ARHGAP26: view

Human Phenotype Ontology for ARHGAP26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP26 Gene

Localization for ARHGAP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ARHGAP26 Gene COMPARTMENTS Subcellular localization image for ARHGAP26 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with ARHGAP26: view

Pathways & Interactions for ARHGAP26 Gene

genes like me logo Genes that share pathways with ARHGAP26: view

Pathways by source for ARHGAP26 Gene

1 Cell Signaling Technology pathway for ARHGAP26 Gene
1 BioSystems pathway for ARHGAP26 Gene
3 Reactome pathways for ARHGAP26 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP26 Gene
1 Qiagen pathway for ARHGAP26 Gene

Gene Ontology (GO) - Biological Process for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development NAS 9582072
GO:0030036 actin cytoskeleton organization IEA,NAS 11998687
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA,TAS --
genes like me logo Genes that share ontologies with ARHGAP26: view

No data available for SIGNOR curated interactions for ARHGAP26 Gene

Drugs & Compounds for ARHGAP26 Gene

(1) Drugs for ARHGAP26 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HJC 0350 Pharma 0

(1) ApexBio Compounds for ARHGAP26 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARHGAP26: view

Transcripts for ARHGAP26 Gene

Unigene Clusters for ARHGAP26 Gene

Rho GTPase activating protein 26:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ·
SP1: - - - -
SP2: - -

ExUns: 23c ^ 24
SP1: -

Relevant External Links for ARHGAP26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP26 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for ARHGAP26 Gene

This gene is overexpressed in Frontal cortex (16.3), Breast (13.8), and Cerebrospinal fluid (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP26 Gene

Protein tissue co-expression partners for ARHGAP26 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP26 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP26 Gene:

genes like me logo Genes that share expression patterns with ARHGAP26: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP26 Gene

Orthologs for ARHGAP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP26 34 35
  • 99.63 (n)
(Canis familiaris)
Mammalia ARHGAP26 34 35
  • 94.31 (n)
(Bos Taurus)
Mammalia ARHGAP26 34 35
  • 93.86 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGAP26 35
  • 93 (a)
(Monodelphis domestica)
Mammalia ARHGAP26 35
  • 91 (a)
(Mus musculus)
Mammalia Arhgap26 34 16 35
  • 90.95 (n)
(Rattus norvegicus)
Mammalia Arhgap26 34
  • 90.65 (n)
(Gallus gallus)
Aves ARHGAP26 34 35
  • 81.14 (n)
(Anolis carolinensis)
Reptilia ARHGAP26 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap26 34
  • 73.99 (n)
(Danio rerio)
Actinopterygii arhgap42a 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Graf 34 35
  • 52.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013143 34
  • 51.58 (n)
(Caenorhabditis elegans)
Secernentea T04C9.1 34 35
  • 53.57 (n)
Species where no ortholog for ARHGAP26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP26 Gene

Gene Tree for ARHGAP26 (if available)
Gene Tree for ARHGAP26 (if available)

Paralogs for ARHGAP26 Gene Pseudogenes for ARHGAP26 Gene

genes like me logo Genes that share paralogs with ARHGAP26: view

Variants for ARHGAP26 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP26 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs121918546 Leukemia, juvenile myelomonocytic (JMML) [MIM:607785], Pathogenic 143,041,855(+) TGTCA(A/C/G)CTCCA nc-transcript-variant, reference, missense
rs139391817 untested 142,932,125(+) GAACC(C/T)GTAAG nc-transcript-variant, reference, synonymous-codon
rs200573018 untested 143,134,097(+) GTCAA(C/T)AGAGA nc-transcript-variant, reference, missense
rs562055157 untested 143,207,377(+) TCTTC(A/G)TGCAG intron-variant, nc-transcript-variant, reference, missense
rs587778047 untested 143,041,850(+) GTGGG(GTGGGG/T)GTCAA nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP26 Gene

Variant ID Type Subtype PubMed ID
esv25431 CNV loss 19812545
esv2673894 CNV deletion 23128226
esv3357911 CNV duplication 20981092
esv3373766 CNV insertion 20981092
esv3419200 CNV duplication 20981092
esv3441979 CNV insertion 20981092
esv3449609 CNV duplication 20981092
esv3570475 CNV loss 25503493
esv3606999 CNV gain 21293372
esv3607005 CNV gain 21293372
esv3607010 CNV loss 21293372
esv3607011 CNV gain 21293372
esv3607012 CNV loss 21293372
esv3607013 CNV gain 21293372
esv3607014 CNV loss 21293372
nsv1025662 CNV loss 25217958
nsv1031126 CNV gain 25217958
nsv1128195 CNV deletion 24896259
nsv1140576 CNV deletion 24896259
nsv473426 CNV novel sequence insertion 20440878
nsv475872 CNV novel sequence insertion 20440878
nsv5040 CNV insertion 18451855
nsv507298 OTHER sequence alteration 20534489
nsv522807 CNV loss 19592680
nsv599925 CNV loss 21841781
nsv830510 CNV gain 17160897
nsv830511 CNV gain 17160897
nsv950419 CNV duplication 24416366
nsv950420 CNV duplication 24416366

Variation tolerance for ARHGAP26 Gene

Residual Variation Intolerance Score: 4.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Disorders for ARHGAP26 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ARHGAP26 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
pancreatic intraductal papillary-mucinous neoplasm
- elite association - COSMIC cancer census association via MalaCards


  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). {ECO:0000269 PubMed:10908648}.

Relevant External Links for ARHGAP26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGAP26: view

No data available for Genatlas for ARHGAP26 Gene

Publications for ARHGAP26 Gene

  1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. (PMID: 10908648) Borkhardt A. … Lampert F. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3 46 64
  4. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. (PMID: 9858476) Taylor J.M. … Parsons J.T. (J. Cell. Sci. 1999) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64

Products for ARHGAP26 Gene

Sources for ARHGAP26 Gene

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