Aliases for ARHGAP26 Gene
External Ids for ARHGAP26 Gene
Previous GeneCards Identifiers for ARHGAP26 Gene
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for ARHGAP26 Gene
ARHGAP26 (Rho GTPase Activating Protein 26) is a Protein Coding gene. Diseases associated with ARHGAP26 include Leukemia, Acute Myelomonocytic, Somatic, Somatic and Myelodysplastic Syndrome. Among its related pathways are Signaling by GPCR and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP10.
UniProtKB/Swiss-Prot for ARHGAP26 Gene
GTPase-activating protein for RHOA and CDC42.