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Aliases for ARHGAP25 Gene

Aliases for ARHGAP25 Gene

  • Rho GTPase Activating Protein 25 2 3 5
  • Rho-Type GTPase-Activating Protein 25 3 4
  • Epididymis Secretory Protein Li 308 3
  • Rho GTPase-Activating Protein 25 3
  • HEL-S-308 3
  • KAIA0053 3
  • KIAA0053 4

External Ids for ARHGAP25 Gene

Previous GeneCards Identifiers for ARHGAP25 Gene

  • GC02P068936
  • GC02P068913
  • GC02P068906

Summaries for ARHGAP25 Gene

Entrez Gene Summary for ARHGAP25 Gene

  • ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP25 Gene

ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP22.

UniProtKB/Swiss-Prot for ARHGAP25 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP25 Gene

Genomics for ARHGAP25 Gene

Regulatory Elements for ARHGAP25 Gene

Enhancers for ARHGAP25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F068761 1.4 FANTOM5 ENCODE 26.3 +89.8 89779 16.7 ATF1 PKNOX1 CREB3L1 ZNF133 YY1 ELK1 GATA2 CBX5 JUNB NFIL3 ARHGAP25 FBXO48 APLF ENSG00000237576 PLEK LOC105374790
GH02F068805 1.5 FANTOM5 Ensembl ENCODE 8.5 +128.5 128533 5.0 PKNOX1 NFRKB PTRF FEZF1 FOS CEBPB MEF2D ZNF589 MAFF SMARCA4 PLEK ENSG00000237576 BMP10 ARHGAP25 FBXO48 LINC01890 APLF LOC105374790
GH02F068732 1.2 FANTOM5 ENCODE 9.8 +58.6 58594 12.0 PKNOX1 TBL1XR1 KAT2B ZNF366 EGR2 USF2 CEBPB TBX21 RAD51 SMARCA4 PLEK ENSG00000237576 ARHGAP25 FBXO48 APLF LOC105374790
GH02F068827 1.7 FANTOM5 Ensembl ENCODE 5.4 +153.4 153370 10.5 PKNOX1 FEZF1 ZNF2 YY1 FOS SP3 JUNB REST MEF2D ZNF610 PLEK FBXO48 LINC01890 APLF BMP10 ARHGAP25 ENSG00000237576
GH02F068750 1.1 Ensembl ENCODE 7.4 +73.6 73647 5.1 ELF3 CBX3 PLRG1 ZNF48 RAD21 CHAMP1 YY1 ZNF366 ELK1 ZNF143 ENSG00000237576 WDR92 APLF FBXO48 ARHGAP25 LOC105374790
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001823724 200 799 HDAC1 ATF1 PKNOX1 ARNT CREB3L1 NFRKB SIN3A CHAMP1 ZBTB2 ZEB2

Genomic Location for ARHGAP25 Gene

Chromosome:
2
Start:
68,679,601 bp from pter
End:
68,826,833 bp from pter
Size:
147,233 bases
Orientation:
Plus strand

Genomic View for ARHGAP25 Gene

Genes around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP25 Gene

Proteins for ARHGAP25 Gene

  • Protein details for ARHGAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42331-RHG25_HUMAN
    Recommended name:
    Rho GTPase-activating protein 25
    Protein Accession:
    P42331
    Secondary Accessions:
    • A8K2Y1
    • B7Z498
    • E9PFQ7
    • G5E9G2
    • Q8IXQ2

    Protein attributes for ARHGAP25 Gene

    Size:
    645 amino acids
    Molecular mass:
    73435 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA06125.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP25 Gene

    Alternative splice isoforms for ARHGAP25 Gene

neXtProt entry for ARHGAP25 Gene

Post-translational modifications for ARHGAP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP25 Gene

Domains & Families for ARHGAP25 Gene

Protein Domains for ARHGAP25 Gene

Suggested Antigen Peptide Sequences for ARHGAP25 Gene

Graphical View of Domain Structure for InterPro Entry

P42331

UniProtKB/Swiss-Prot:

RHG25_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP25: view

Function for ARHGAP25 Gene

Molecular function for ARHGAP25 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view
genes like me logo Genes that share phenotypes with ARHGAP25: view

Animal Models for ARHGAP25 Gene

MGI Knock Outs for ARHGAP25:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP25 Gene

Localization for ARHGAP25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP25 gene
Compartment Confidence
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP25 Gene

Pathways & Interactions for ARHGAP25 Gene

genes like me logo Genes that share pathways with ARHGAP25: view

Pathways by source for ARHGAP25 Gene

3 Reactome pathways for ARHGAP25 Gene

Gene Ontology (GO) - Biological Process for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for SIGNOR curated interactions for ARHGAP25 Gene

Transcripts for ARHGAP25 Gene

Unigene Clusters for ARHGAP25 Gene

Rho GTPase activating protein 25:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for ARHGAP25 Gene

GeneLoc Exon Structure for
ARHGAP25
ECgene alternative splicing isoforms for
ARHGAP25

Expression for ARHGAP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP25 Gene

This gene is overexpressed in Whole Blood (x24.9) and Spleen (x6.0).

Protein differential expression in normal tissues from HIPED for ARHGAP25 Gene

This gene is overexpressed in Serum (26.6), Lymph node (12.4), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP25 Gene



Protein tissue co-expression partners for ARHGAP25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP25 Gene:

ARHGAP25

SOURCE GeneReport for Unigene cluster for ARHGAP25 Gene:

Hs.531807
genes like me logo Genes that share expression patterns with ARHGAP25: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP25 Gene

Orthologs for ARHGAP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP25 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia ARHGAP25 34 35
  • 88.65 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap25 34
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Arhgap25 34 16 35
  • 85.04 (n)
dog
(Canis familiaris)
Mammalia ARHGAP25 34 35
  • 82.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARHGAP25 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP25 34 35
  • 68.23 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP25 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap25 34
  • 60.71 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgap25 34 35
  • 54.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for ARHGAP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP25 Gene

ENSEMBL:
Gene Tree for ARHGAP25 (if available)
TreeFam:
Gene Tree for ARHGAP25 (if available)

Paralogs for ARHGAP25 Gene

(8) SIMAP similar genes for ARHGAP25 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARHGAP25: view

Variants for ARHGAP25 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10048745 -- 68,735,005(+) CAGAT(A/G)GATGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10167306 -- 68,768,784(+) TTGAA(A/G)CTCTC intron-variant
rs10167610 -- 68,823,254(+) TTAGG(A/G)TATAG intron-variant
rs10167976 -- 68,728,684(+) ttgag(C/T)ccaga intron-variant
rs10170087 -- 68,769,329(+) GCAGG(A/C)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP25 Gene

Variant ID Type Subtype PubMed ID
nsv997947 CNV gain 25217958
nsv953141 CNV duplication 24416366
nsv476671 CNV novel sequence insertion 20440878
dgv3862n100 CNV gain 25217958

Variation tolerance for ARHGAP25 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP25 Gene

Disorders for ARHGAP25 Gene

Relevant External Links for ARHGAP25

Genetic Association Database (GAD)
ARHGAP25
Human Genome Epidemiology (HuGE) Navigator
ARHGAP25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP25

No disorders were found for ARHGAP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP25 Gene

Publications for ARHGAP25 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  3. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ARHGAP25 Gene

Sources for ARHGAP25 Gene

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