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Aliases for ARHGAP25 Gene

Aliases for ARHGAP25 Gene

  • Rho GTPase Activating Protein 25 2 3
  • Rho-Type GTPase-Activating Protein 25 3 4
  • KAIA0053 3 6
  • Epididymis Secretory Protein Li 308 3
  • Rho GTPase-Activating Protein 25 3
  • HEL-S-308 3
  • KIAA0053 4

External Ids for ARHGAP25 Gene

Previous GeneCards Identifiers for ARHGAP25 Gene

  • GC02P068936
  • GC02P068913
  • GC02P068906

Summaries for ARHGAP25 Gene

Entrez Gene Summary for ARHGAP25 Gene

  • ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP25 Gene

ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP25 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP25 Gene

Genomics for ARHGAP25 Gene

Regulatory Elements for ARHGAP25 Gene

Genomic Location for ARHGAP25 Gene

Start:
68,679,601 bp from pter
End:
68,826,833 bp from pter
Size:
147,233 bases
Orientation:
Plus strand

Genomic View for ARHGAP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP25 Gene

Proteins for ARHGAP25 Gene

  • Protein details for ARHGAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42331-RHG25_HUMAN
    Recommended name:
    Rho GTPase-activating protein 25
    Protein Accession:
    P42331
    Secondary Accessions:
    • A8K2Y1
    • B7Z498
    • E9PFQ7
    • G5E9G2
    • Q8IXQ2

    Protein attributes for ARHGAP25 Gene

    Size:
    645 amino acids
    Molecular mass:
    73435 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA06125.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP25 Gene

    Alternative splice isoforms for ARHGAP25 Gene

neXtProt entry for ARHGAP25 Gene

Proteomics data for ARHGAP25 Gene at MOPED

Post-translational modifications for ARHGAP25 Gene

  • Ubiquitination at Lys208
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ARHGAP25 Gene

Domains for ARHGAP25 Gene

Gene Families for ARHGAP25 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for ARHGAP25 Gene

Suggested Antigen Peptide Sequences for ARHGAP25 Gene

Graphical View of Domain Structure for InterPro Entry

P42331

UniProtKB/Swiss-Prot:

RHG25_HUMAN :
  • P42331
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP25: view

Function for ARHGAP25 Gene

Molecular function for ARHGAP25 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP25: view

Phenotypes for ARHGAP25 Gene

genes like me logo Genes that share phenotypes with ARHGAP25: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP25 Gene

Localization for ARHGAP25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP25 Gene COMPARTMENTS Subcellular localization image for ARHGAP25 gene
Compartment Confidence
cytosol 4
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP25 Gene

Pathways for ARHGAP25 Gene

genes like me logo Genes that share pathways with ARHGAP25: view

Pathways by source for ARHGAP25 Gene

3 Reactome pathways for ARHGAP25 Gene

Interacting Proteins for ARHGAP25 Gene

Gene Ontology (GO) - Biological Process for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

Transcripts for ARHGAP25 Gene

Unigene Clusters for ARHGAP25 Gene

Rho GTPase activating protein 25:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP25

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for ARHGAP25 Gene

GeneLoc Exon Structure for
ARHGAP25
ECgene alternative splicing isoforms for
ARHGAP25

Expression for ARHGAP25 Gene

mRNA expression in normal human tissues for ARHGAP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP25 Gene

This gene is overexpressed in Whole Blood (24.9) and Spleen (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP25 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP25 Gene Hs.531807

genes like me logo Genes that share expressions with ARHGAP25: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP25 Gene

Orthologs for ARHGAP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP25 35
  • 99.74 (n)
  • 99.85 (a)
ARHGAP25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP25 35
  • 88.65 (n)
  • 90 (a)
ARHGAP25 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP25 35
  • 82.19 (n)
  • 79.81 (a)
ARHGAP25 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap25 35
  • 85.04 (n)
  • 87.31 (a)
Arhgap25 16
Arhgap25 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP25 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgap25 35
  • 85.4 (n)
  • 86.84 (a)
chicken
(Gallus gallus)
Aves ARHGAP25 35
  • 68.23 (n)
  • 65.86 (a)
ARHGAP25 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP25 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap25 35
  • 60.71 (n)
  • 53.92 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap25 35
  • 54.33 (n)
  • 47.47 (a)
arhgap25 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ARHGAP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP25 Gene

ENSEMBL:
Gene Tree for ARHGAP25 (if available)
TreeFam:
Gene Tree for ARHGAP25 (if available)

Paralogs for ARHGAP25 Gene

Selected SIMAP similar genes for ARHGAP25 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARHGAP25: view

Variants for ARHGAP25 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9902 -- 68,826,425(+) TTGTT(C/T)TATTC utr-variant-3-prime
rs868434 -- 68,816,563(+) TGAAC(A/G)TGCTC intron-variant
rs939058 -- 68,808,429(-) GCGGC(A/G)TTGGT intron-variant
rs939059 -- 68,811,153(+) AGTGG(C/G)CAGAG intron-variant
rs939060 -- 68,816,549(+) GTTGA(A/C)CCAAA intron-variant

Relevant External Links for ARHGAP25 Gene

HapMap Linkage Disequilibrium report
ARHGAP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGAP25 Gene

Disorders for ARHGAP25 Gene

Relevant External Links for ARHGAP25

Genetic Association Database (GAD)
ARHGAP25
Human Genome Epidemiology (HuGE) Navigator
ARHGAP25
genes like me logo Genes that share disorders with ARHGAP25: view

No data available for UniProtKB/Swiss-Prot for ARHGAP25 Gene

Publications for ARHGAP25 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ARHGAP25 Gene

Sources for ARHGAP25 Gene

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