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ARHGAP25 Gene

protein-coding   GIFtS: 54
GCID: GC02P068906

Rho GTPase Activating Protein 25

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 251 2     Epididymis Secretory Protein Li 3082
Rho-Type GTPase-Activating Protein 252 3     Rho GTPase-Activating Protein 252
KAIA00532 5     KIAA00533
HEL-S-3082     

External Ids:    HGNC: 289511   Entrez Gene: 99382   Ensembl: ENSG000001632197   OMIM: 6105875   UniProtKB: P423313   

Export aliases for ARHGAP25 gene to outside databases

Previous GC identifers: GC02P068936 GC02P068913 GC02P068698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP25 Gene:
ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated
in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 (PubMed 15254788)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ARHGAP25 Gene:
ARHGAP25 (Rho GTPase activating protein 25) is a protein-coding gene. Diseases associated with ARHGAP25 include spasticity. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG25_HUMAN, P42331
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP25 gene promoter:
         HOXA9B   HOXA9   CUTL1   Evi-1   PPAR-gamma1   PPAR-gamma2   Meis-1a   Pax-4a   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGAP25 promoter sequence
   Search Chromatin IP Primers for ARHGAP25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

ARHGAP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP25 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P068906:  view genomic region     (about GC identifiers)

Start:
68,906,733 bp from pter      End:
69,053,965 bp from pter
Size:
147,233 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHG25_HUMAN, P42331 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 25  
Size: 645 amino acids; 73435 Da
Sequence caution: Sequence=BAA06125.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ARHGAP25:
1V89 (3D)    
Secondary accessions: A8K2Y1 B7Z498 E9PFQ7 G5E9G2 Q8IXQ2
Alternative splicing: 6 isoforms:  P42331-1   P42331-2   P42331-3   P42331-4   P42331-5   P42331-6   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for ARHGAP25: NX_P42331

Explore proteomics data for ARHGAP25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208
  • Modification sites at PhosphoSitePlus

  • See ARHGAP25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007232.2  NP_001159748.1  NP_001159749.1  NP_055697.1  

    ENSEMBL proteins: 
     ENSP00000417283   ENSP00000386911   ENSP00000420583   ENSP00000420427   ENSP00000386863  
     ENSP00000386241   ENSP00000417425   ENSP00000417139   ENSP00000417818   ENSP00000417467  
     ENSP00000295381   ENSP00000439917  
    Reactome Protein details: P42331

    ARHGAP25 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry P42331

    ProtoNet protein and cluster: P42331

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG25_HUMAN, P42331
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG25_HUMAN, P42331
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    ARHGAP25 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap25):
     pigmentation  vision/eye 

    ARHGAP25 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP25
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ARHGAP25:
    hsa-miR-4291 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP25 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP25

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGAP25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP25 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP25
        Rho GTPase cycle



    ARHGAP25 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP25
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP25

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARHGAP25 (ENSP000002953814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000002638454STRING: ENSP00000263845
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP25 (RHG25)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGAP25 gene (4 alternative transcripts): 
    NM_001007231.2  NM_001166276.1  NM_001166277.1  NM_014882.2  

    Unigene Cluster for ARHGAP25:

    Rho GTPase activating protein 25
    Hs.531807  [show with all ESTs]
    Unigene Representative Sequence: NM_001007231
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000463483(uc010yqk.2) ENST00000481684 ENST00000491237 ENST00000409202
    ENST00000456116 ENST00000467265 ENST00000485573 ENST00000488795 ENST00000463061
    ENST00000485700 ENST00000496266 ENST00000409030(uc002sew.3) ENST00000409220(uc002sex.3)
    ENST00000473986(uc010fdh.1) ENST00000497079(uc002sev.3) ENST00000497259
    ENST00000479844 ENST00000295381(uc010fdg.3 uc010yql.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ARHGAP25:
    hsa-miR-4291 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP25 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGAP25
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP25
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP25
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP25

    Additional mRNA sequence: 

    AK290396.1 AK297056.1 AK297157.1 AK298669.1 AK303591.1 AK310742.1 AK311669.1 BC032222.1 
    BC039591.1 D29642.1 

    11 DOTS entries:

    DT.313185  DT.97822313  DT.97789708  DT.100776740  DT.102828731  DT.91855476  DT.100697288  DT.120988870 
    DT.120988886  DT.120988896  DT.120988909 

    Selected AceView cDNA sequences (see all 80):

    BQ073007 BQ067474 AI612855 BC032222 AI434357 BI030380 CR617270 AA280844 
    BX101295 CR603706 D29642 BI518793 AI567925 AA554388 AI675462 BM988983 
    AA280922 CR607155 AA811916 BU176833 BC039591 AW275501 BX325004 BX443252 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP25 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                                      -                                                           -               
    SP2:                                      -                                                                           
    SP3:                                                  -                                                               
    SP4:                                      -           -                                                               
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for ARHGAP25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP25 Expression
    About this image


    ARHGAP25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    ARHGAP25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531807
        Custom PCR Arrays for ARHGAP25
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP25 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap251 , 5 Rho GTPase activating protein 251, 5 85.04(n)1
    87.31(a)1
      6 (38.01 cM)5
    2322011  NM_001037727.21  NP_001032816.11 
     874585455 
    chicken
    (Gallus gallus)
    Aves ARHGAP251 Rho GTPase activating protein 25 68.23(n)
    65.86(a)
      419516  NM_001030883.1  NP_001026054.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP256
    Rho GTPase activating protein 25
    48(a)
    1 ↔ 1
    AAWZ02040531(1406-5564)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap251 Rho GTPase activating protein 25 60.71(n)
    53.92(a)
      448347  NM_001006709.1  NP_001006710.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap251 Rho GTPase activating protein 25 54.33(n)
    47.47(a)
      562468  NM_001126404.1  NP_001119876.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1906
    RhoGAPp190
    5(a)
    1 → many
    X(17533180-17546595)
    worm
    (Caenorhabditis elegans)
    Secernentea rga-56
    Protein RGA-5, isoform a (rga-5) mRNA, complete cd...
    5(a)
    1 → many
    IV(13827886-13844978) WBGene00010374


    ENSEMBL Gene Tree for ARHGAP25 (if available)
    TreeFam Gene Tree for ARHGAP25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP25 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP442  
    SH3BP12  SRGAP22  ARHGAP42  
    8 SIMAP similar genes for ARHGAP25 using alignment to 6 protein entries:     RHG25_HUMAN (see all proteins):
    KIAA0053    ARHGAP22    ARHGAP24    FAM13A    ARHGAP21    CHN2
    ARHGAP31    FAM109A

    ARHGAP25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP25 (see all 2125)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389969321,2
    --68959928(+) AATGCG/TCTTGC 2 -- us2k10--------
    rs1835635481,2
    --68959943(+) TTCTTC/TTCTCT 2 -- us2k10--------
    rs779404901,2
    C,F--68959995(+) CACCAC/GTGTTC 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1869669481,2
    --68960010(+) AGCCTC/TGTTCT 2 -- us2k10--------
    rs746141201,2
    C,F--68960037(+) GATACA/GTTTAG 2 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1910549541,2
    --68960087(+) GATTTG/TGAGTT 2 -- us2k10--------
    rs351051751,2
    C,F--68960335(+) CATGGA/GCAGAG 2 -- us2k16Minor allele frequency- G:0.10NA EA 248
    rs1430245461,2
    C--68960364(+) GCTATC/GAAATG 2 -- us2k10--------
    rs1474714091,2
    --68960374(+) GTGTCC/TGACAC 2 -- us2k10--------
    rs758414011,2
    C,F--68960485(+) AGGGGC/AAAAAA 2 -- us2k15Minor allele frequency- A:0.18CSA WA NA EA 362

    HapMap Linkage Disequilibrium report for ARHGAP25 (68906733 - 69053965 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGAP25: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP25
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610587    OMIM disorders: --

    1 disease for ARHGAP25:    
    About MalaCards
    spasticity


    ARHGAP25 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP25
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP25 (1 document)

    Export disorders for ARHGAP25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP25 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARHGAP25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PubMed id 15254788)1, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)4 Marroni F....Pramstaller P.P. (Circ Cardiovasc Genet 2009)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9938 HGNC: 28951 AceView: ARHGAP25 Ensembl:ENSG00000163219 euGenes: HUgn9938
    ECgene: ARHGAP25 H-InvDB: ARHGAP25

    (According to HUGE)
    About This Section

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    HUGE: KIAA0053

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARHGAP25 gene:
    Search GeneIP for patents involving ARHGAP25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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