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Aliases for ARHGAP25 Gene

Aliases for ARHGAP25 Gene

  • Rho GTPase Activating Protein 25 2 3 5
  • Rho-Type GTPase-Activating Protein 25 3 4
  • Epididymis Secretory Protein Li 308 3
  • HEL-S-308 3
  • KAIA0053 3
  • KIAA0053 4

External Ids for ARHGAP25 Gene

Previous GeneCards Identifiers for ARHGAP25 Gene

  • GC02P068936
  • GC02P068913
  • GC02P068906

Summaries for ARHGAP25 Gene

Entrez Gene Summary for ARHGAP25 Gene

  • ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP25 Gene

ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP25 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP25 Gene

Genomics for ARHGAP25 Gene

Regulatory Elements for ARHGAP25 Gene

Enhancers for ARHGAP25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP25 Gene

68,679,601 bp from pter
68,826,833 bp from pter
147,233 bases
Plus strand

Genomic View for ARHGAP25 Gene

Genes around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP25 Gene

Proteins for ARHGAP25 Gene

  • Protein details for ARHGAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 25
    Protein Accession:
    Secondary Accessions:
    • A8K2Y1
    • B7Z498
    • E9PFQ7
    • G5E9G2
    • Q8IXQ2

    Protein attributes for ARHGAP25 Gene

    645 amino acids
    Molecular mass:
    73435 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA06125.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP25 Gene

    Alternative splice isoforms for ARHGAP25 Gene

neXtProt entry for ARHGAP25 Gene

Proteomics data for ARHGAP25 Gene at MOPED

Post-translational modifications for ARHGAP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP25 Gene

Domains & Families for ARHGAP25 Gene

Protein Domains for ARHGAP25 Gene

Suggested Antigen Peptide Sequences for ARHGAP25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP25: view

Function for ARHGAP25 Gene

Molecular function for ARHGAP25 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
genes like me logo Genes that share phenotypes with ARHGAP25: view

Animal Models for ARHGAP25 Gene

MGI Knock Outs for ARHGAP25:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP25 Gene

Localization for ARHGAP25 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP25 Gene COMPARTMENTS Subcellular localization image for ARHGAP25 gene
Compartment Confidence
cytosol 5
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP25 Gene

Pathways & Interactions for ARHGAP25 Gene

genes like me logo Genes that share pathways with ARHGAP25: view

Pathways by source for ARHGAP25 Gene

3 Reactome pathways for ARHGAP25 Gene

Interacting Proteins for ARHGAP25 Gene

Gene Ontology (GO) - Biological Process for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for SIGNOR curated interactions for ARHGAP25 Gene

Drugs & Compounds for ARHGAP25 Gene

No Compound Related Data Available

Transcripts for ARHGAP25 Gene

Unigene Clusters for ARHGAP25 Gene

Rho GTPase activating protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for ARHGAP25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP25 Gene

mRNA expression in normal human tissues for ARHGAP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP25 Gene

This gene is overexpressed in Whole Blood (x24.9) and Spleen (x6.0).

Protein differential expression in normal tissues from HIPED for ARHGAP25 Gene

This gene is overexpressed in Serum (26.6), Lymph node (12.4), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP25 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP25 Gene Hs.531807

genes like me logo Genes that share expression patterns with ARHGAP25: view

Protein tissue co-expression partners for ARHGAP25 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP25 Gene

Orthologs for ARHGAP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP25 35
  • 88.65 (n)
  • 90 (a)
  • 90 (a)
(Canis familiaris)
Mammalia ARHGAP25 35
  • 82.19 (n)
  • 79.81 (a)
  • 79 (a)
(Mus musculus)
Mammalia Arhgap25 35
  • 85.04 (n)
  • 87.31 (a)
Arhgap25 16
Arhgap25 36
  • 87 (a)
(Pan troglodytes)
Mammalia ARHGAP25 35
  • 99.74 (n)
  • 99.85 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arhgap25 35
  • 85.4 (n)
  • 86.84 (a)
(Monodelphis domestica)
Mammalia ARHGAP25 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
-- 36
  • 45 (a)
-- 36
  • 77 (a)
(Gallus gallus)
Aves ARHGAP25 35
  • 68.23 (n)
  • 65.86 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia ARHGAP25 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap25 35
  • 60.71 (n)
  • 53.92 (a)
(Danio rerio)
Actinopterygii arhgap25 35
  • 54.33 (n)
  • 47.47 (a)
arhgap25 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for ARHGAP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP25 Gene

Gene Tree for ARHGAP25 (if available)
Gene Tree for ARHGAP25 (if available)

Paralogs for ARHGAP25 Gene

(8) SIMAP similar genes for ARHGAP25 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARHGAP25: view

Variants for ARHGAP25 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3749130 - 68,807,383(-) ATTCC(A/G)GCCGT upstream-variant-2KB, reference, missense
rs4241344 - 68,822,807(+) CAGAG(C/G/T)ATGGT reference, missense
rs10177248 - 68,822,809(+) GAGGA(C/T)GGTCC reference, missense
rs1578878 -- 68,793,531(+) aaggg(A/C/T)gtctt intron-variant
rs868434 -- 68,816,563(+) TGAAC(A/G)TGCTC intron-variant

Variation tolerance for ARHGAP25 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ARHGAP25 Gene

Disorders for ARHGAP25 Gene

Relevant External Links for ARHGAP25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGAP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP25 Gene

Publications for ARHGAP25 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
  2. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3

Products for ARHGAP25 Gene

Sources for ARHGAP25 Gene