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ARHGAP24 Gene

protein-coding   GIFtS: 56
GCID: GC04P086396

Rho GTPase Activating Protein 24

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 241 2     p73RhoGAP2 3
FILGAP2 3 5     RAC1- And CDC42-Specific GTPase-Activating Protein Of 72 KDa2 3
Filamin-A-Associated RhoGAP2 3     RCGAP722 5
Rho-Type GTPase-Activating Protein 242 3     p732
RhoGAP Of 73 KDa2 3     Rho GTPase-Activating Protein 242
Sarcoma Antigen NY-SAR-882 3     FilGAP3
RC-GAP722 3     

External Ids:    HGNC: 253611   Entrez Gene: 834782   Ensembl: ENSG000001386397   OMIM: 6105865   UniProtKB: Q8N2643   

Export aliases for ARHGAP24 gene to outside databases

Previous GC identifers: GC04P086951 GC04P086848 GC04P086615 GC04P082138


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP24 Gene:
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated
in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 (PubMed 15254788)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ARHGAP24 Gene:
ARHGAP24 (Rho GTPase activating protein 24) is a protein-coding gene. Diseases associated with ARHGAP24 include focal segmental glomerulosclerosis, and sarcoma. GO annotations related to this gene include Rac GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG24_HUMAN, Q8N264
Function: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization.
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls
actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes
cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression
induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane
ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of
angiogenesis

Gene Wiki entry for ARHGAP24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP24 gene promoter:
         c-Fos   TBP   AP-1   FOXF2   IRF-1   STAT5A   E47   MEF-2A   aMEF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGAP24 promoter sequence
   Search Chromatin IP Primers for ARHGAP24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q22.1

ARHGAP24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP24 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P086396:  view genomic region     (about GC identifiers)

Start:
86,396,267 bp from pter      End:
86,923,823 bp from pter
Size:
527,557 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHG24_HUMAN, Q8N264 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 24  
Size: 748 amino acids; 84258 Da
Subunit: Interacts with FLNA
Sequence caution: Sequence=AAO65178.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q4KMG1 Q6ZNV3 Q86TI5 Q86WE4 Q9H0T6
Alternative splicing: 5 isoforms:  Q8N264-1   Q8N264-2   Q8N264-3   Q8N264-4   Q8N264-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP24: NX_Q8N264

Explore proteomics data for ARHGAP24 at MOPED

Post-translational modifications: 

  • Phosphorylated by ROCK, leading to activate the RacGAP activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020787.2  NP_001036134.1  NP_001274734.1  NP_112595.2  

    ENSEMBL proteins: 
     ENSP00000378611   ENSP00000423206   ENSP00000426105   ENSP00000378610   ENSP00000424256  
     ENSP00000425589   ENSP00000264343  
    Reactome Protein details: Q8N264

    ARHGAP24 Human Recombinant Protein Products:

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    Novus Biologicals ARHGAP24 Protein
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    Cloud-Clone Corp. Proteins for ARHGAP24

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q8N264

    ProtoNet protein and cluster: Q8N264

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG24_HUMAN, Q8N264
    Domain: The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG24_HUMAN, Q8N264
    Function: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization.
    Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls
    actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes
    cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression
    induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane
    ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of
    angiogenesis
    Induction: Isoform 2 is up-regulated during capillary tube formation in umbilical vein endothelial cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005515protein binding IPI16862148
    GO:0030675Rac GTPase activator activity IEA--
         
    ARHGAP24 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP24:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP24
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP24 (see all 67):
    hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-200a hsa-miR-519a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP24 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGAP24
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP24

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): ARHGAP24 (NM_001025616)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG24_HUMAN, Q8N264: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion.
    Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and
    protusions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane4
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane ----

    ARHGAP24 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP24 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARHGAP24
        G-protein signaling Regulation of RAC1 activity

    1 Reactome Pathway for ARHGAP24
        Rho GTPase cycle



    ARHGAP24 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP24
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP24

    3 Interacting proteins for ARHGAP24 (Q8N2641, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNAP213331, 3EBI-988764,EBI-350432 I2D: score=2 
    CDC42P609533I2D: score=1 
    ROCK1Q134643I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0030154cell differentiation IEA--
    GO:0032863activation of Rac GTPase activity IEA--

    ARHGAP24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP24 (RHG24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGAP24 gene (4 alternative transcripts): 
    NM_001025616.2  NM_001042669.1  NM_001287805.1  NM_031305.2  

    Unigene Cluster for ARHGAP24:

    Rho GTPase activating protein 24
    Hs.444229  [show with all ESTs]
    Unigene Representative Sequence: NM_001025616
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395184(uc003hpi.1 uc003hpk.3 uc003hpl.3 uc010ikf.3)
    ENST00000503995(uc003hpj.3) ENST00000506421 ENST00000505856 ENST00000509709
    ENST00000512201 ENST00000395183 ENST00000509300 ENST00000514229 ENST00000502537
    ENST00000503917 ENST00000264343(uc003hpm.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP24 (see all 67):
    hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-200a hsa-miR-519a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP24 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP24
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP24
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP24

    Additional mRNA sequence: 

    AK091196.1 AK098193.1 AK130576.1 AK307423.1 AK308019.1 AL136646.1 AY211925.1 BC047918.1 
    BC098580.1 

    15 DOTS entries:

    DT.99933434  DT.97837112  DT.413106  DT.121237923  DT.40128917  DT.100814030  DT.100711697  DT.100678375 
    DT.65286411  DT.95261947  DT.91958605  DT.100651274  DT.100743867  DT.121238076  DT.92421298 

    Selected AceView cDNA sequences (see all 130):

    H96341 AI991447 BU742014 BQ014207 BM090711 AA236224 AA831191 AA932896 
    AI494054 AI355620 CR617684 CR601064 BM557573 BM704155 BX387228 AI867201 
    AI097475 AA670359 BX115145 AI761743 AI246704 AI261598 AI373892 AI934372 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP24 expression in normal human tissues (normalized intensities)      ARHGAP24 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCATAATG
    ARHGAP24 Expression
    About this image


    ARHGAP24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Mesoderm-like cells
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Rib
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Neural Tube (Nervous System)
             Metencephalon
    ARHGAP24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444229

    UniProtKB/Swiss-Prot: RHG24_HUMAN, Q8N264
    Tissue specificity: Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in
    endothelial cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP24 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap241 , 5 Rho GTPase activating protein 241, 5 86.42(n)1
    93.03(a)1
      5 (49.53 cM)5
    2315321  NM_029270.21  NP_083546.21 
     1024813915 
    chicken
    (Gallus gallus)
    Aves ARHGAP241 Rho GTPase activating protein 24 77.79(n)
    84.58(a)
      422593  XM_004941109.1  XP_004941166.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP246
    Rho GTPase activating protein 24
    82(a)
    1 ↔ 1
    5(44553656-44613741)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap241 Rho GTPase activating protein 24 73.13(n)
    80.22(a)
      100488856  XM_004911066.1  XP_004911123.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap241 Rho GTPase activating protein 24 69.03(n)
    74.18(a)
      100005116  XM_001338974.3  XP_001339010.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1906
    RhoGAPp190
    4(a)
    1 → many
    X(17533180-17546595)
    worm
    (Caenorhabditis elegans)
    Secernentea rga-56
    Protein RGA-5, isoform a (rga-5) mRNA, complete cd...
    5(a)
    1 → many
    IV(13827886-13844978) WBGene00010374


    ENSEMBL Gene Tree for ARHGAP24 (if available)
    TreeFam Gene Tree for ARHGAP24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP24 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP442  SH3BP12  
    ARHGAP252  SRGAP22  ARHGAP42  
    Selected SIMAP similar genes for ARHGAP24 using alignment to 4 protein entries:     RHG24_HUMAN (see all proteins) (see all similar genes):
    MYO9A    FAM13B    ARHGAP22    CHN1    OPHN1    SH3BP1
    CHN2    MYO9B    ARHGAP25    ARHGAP21    HMHA1    PIK3R1
    ARHGAP19    ARHGAP27    ARHGAP31    ARHGAP1    ARHGAP10    ARHGAP23

    ARHGAP24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP24 (see all 10966)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709487341,2
    C--86291146(+) TTTTT-/TTTT  
      
    /TTTTT
    GTATT
    1 -- int11NA 2
    rs1859583811,2
    --86394321(+) AAGAAA/GGGGCT 1 -- us2k10--------
    rs1908653181,2
    --86394483(+) AGAACC/GAGAAG 1 -- us2k10--------
    rs1839322751,2
    --86394485(+) AACCAA/GAAGAT 1 -- us2k10--------
    rs1889541451,2
    --86394627(+) TATTTA/GTTAGA 1 -- us2k10--------
    rs760369051,2
    C,F--86394633(+) TTAGAC/TCCTGA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1930646711,2
    --86394783(+) CTTTCA/CTCTGA 1 -- us2k10--------
    rs285392061,2
    C,F,H--86394813(+) CCTGCT/CAGGGT 1 -- us2k110Minor allele frequency- C:0.19NS NA CSA WA 1190
    rs1469349161,2
    C--86394831(+) GAACAC/TGTAAG 1 -- us2k10--------
    rs340019001,2
    C,F--86394977(+) TTCATT/AAAAGG 1 -- us2k17Minor allele frequency- A:0.11NA CSA WA EA 366

    HapMap Linkage Disequilibrium report for ARHGAP24 (86396267 - 86646267 bp, first 250kb of ARHGAP24)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP24 (see all 53):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2234618CNV Deletion18987734
    esv2665029CNV Deletion23128226
    esv2592051CNV Deletion19546169
    esv2228589CNV Deletion18987734
    esv2727925CNV Deletion23290073
    esv1340531CNV Deletion17803354
    esv2660474CNV Deletion23128226
    esv2727922CNV Deletion23290073
    esv4911CNV Deletion18987735
    esv2727923CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ARHGAP24
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP24
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610586    OMIM disorders: --

    7 diseases for ARHGAP24:    About MalaCards
    focal segmental glomerulosclerosis    sarcoma    lymphoblastic leukemia    cervicitis
    leukemia    obesity    endotheliitis


    ARHGAP24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP24
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP24 (3 documents)

    Export disorders for ARHGAP24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ARHGAP24 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with ARHGAP24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PubMed id 15254788)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. (PubMed id 15302923)1, 2, 9 Su Z.-J.... Gamble J.R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton. (PubMed id 15611138)1, 2, 9 Lavelin I. and Geiger B. (J. Biol. Chem. 2005)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma. (PubMed id 20670164)1, 4 Horinouchi M....Nakamura T. (Pediatr Hematol Oncol 2010)
    7. Genome-wide association study of PR interval. (PubMed id 20062060)1, 4 Pfeufer A....Heckbert S.R. (Nat. Genet. 2010)
    8. Several common variants modulate heart rate, PR interval and QRS duration. (PubMed id 20062063)1, 4 Holm H....Stefansson K. (Nat. Genet. 2010)
    9. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. (PubMed id 16862148)1, 2 Ohta Y.... Stossel T.P. (Nat. Cell Biol. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 83478 HGNC: 25361 AceView: ARHGAP24 Ensembl:ENSG00000138639 euGenes: HUgn83478
    ECgene: ARHGAP24 H-InvDB: ARHGAP24

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGAP24 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARHGAP24 gene:
    Search GeneIP for patents involving ARHGAP24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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