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Aliases for ARHGAP24 Gene

Aliases for ARHGAP24 Gene

  • Rho GTPase Activating Protein 24 2 3
  • FILGAP 3 4 6
  • RAC1- And CDC42-Specific GTPase-Activating Protein Of 72 KDa 3 4
  • Rho-Type GTPase-Activating Protein 24 3 4
  • Filamin-A-Associated RhoGAP 3 4
  • Sarcoma Antigen NY-SAR-88 3 4
  • RhoGAP Of 73 KDa 3 4
  • P73RhoGAP 3 4
  • RC-GAP72 3 4
  • RCGAP72 3 6
  • Rho GTPase-Activating Protein 24 3
  • P73 3

External Ids for ARHGAP24 Gene

Previous GeneCards Identifiers for ARHGAP24 Gene

  • GC04P086951
  • GC04P086848
  • GC04P086615
  • GC04P086396
  • GC04P082138

Summaries for ARHGAP24 Gene

Entrez Gene Summary for ARHGAP24 Gene

  • ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP24 Gene

ARHGAP24 (Rho GTPase Activating Protein 24) is a Protein Coding gene. Diseases associated with ARHGAP24 include familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP24 Gene

  • Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Gene Wiki entry for ARHGAP24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP24 Gene

Genomics for ARHGAP24 Gene

Regulatory Elements for ARHGAP24 Gene

Genomic Location for ARHGAP24 Gene

Start:
85,147,742 bp from pter
End:
86,002,670 bp from pter
Size:
854,929 bases
Orientation:
Plus strand

Genomic View for ARHGAP24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP24 Gene

Proteins for ARHGAP24 Gene

  • Protein details for ARHGAP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N264-RHG24_HUMAN
    Recommended name:
    Rho GTPase-activating protein 24
    Protein Accession:
    Q8N264
    Secondary Accessions:
    • Q4KMG1
    • Q6ZNV3
    • Q86TI5
    • Q86WE4
    • Q9H0T6

    Protein attributes for ARHGAP24 Gene

    Size:
    748 amino acids
    Molecular mass:
    84258 Da
    Quaternary structure:
    • Interacts with FLNA.
    SequenceCaution:
    • Sequence=AAO65178.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP24 Gene

Proteomics data for ARHGAP24 Gene at MOPED

Post-translational modifications for ARHGAP24 Gene

  • Phosphorylated by ROCK, leading to activate the RacGAP activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP24 Gene

Antibody Products

No data available for DME Specific Peptides for ARHGAP24 Gene

Domains for ARHGAP24 Gene

Gene Families for ARHGAP24 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for ARHGAP24 Gene

Suggested Antigen Peptide Sequences for ARHGAP24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N264

UniProtKB/Swiss-Prot:

RHG24_HUMAN :
  • Q8N264
Domain:
  • The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP24: view

Function for ARHGAP24 Gene

Molecular function for ARHGAP24 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is up-regulated during capillary tube formation in umbilical vein endothelial cells.

Gene Ontology (GO) - Molecular Function for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 16862148
genes like me logo Genes that share ontologies with ARHGAP24: view

Phenotypes for ARHGAP24 Gene

GenomeRNAi human phenotypes for ARHGAP24:
genes like me logo Genes that share phenotypes with ARHGAP24: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP24 Gene

Localization for ARHGAP24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP24 Gene

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP24 Gene COMPARTMENTS Subcellular localization image for ARHGAP24 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGAP24: view

Pathways for ARHGAP24 Gene

genes like me logo Genes that share pathways with ARHGAP24: view

Pathways by source for ARHGAP24 Gene

3 Reactome pathways for ARHGAP24 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP24 Gene

Gene Ontology (GO) - Biological Process for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030154 cell differentiation IEA --
GO:0035021 negative regulation of Rac protein signal transduction IEA --
genes like me logo Genes that share ontologies with ARHGAP24: view

Transcripts for ARHGAP24 Gene

Unigene Clusters for ARHGAP24 Gene

Rho GTPase activating protein 24:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP24

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP24 Gene

No ASD Table

Relevant External Links for ARHGAP24 Gene

GeneLoc Exon Structure for
ARHGAP24
ECgene alternative splicing isoforms for
ARHGAP24

Expression for ARHGAP24 Gene

mRNA expression in normal human tissues for ARHGAP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ARHGAP24 Gene

This gene is overexpressed in Pancreatic juice (24.3), Blymphocyte (23.9), and Adipocyte (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGAP24 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP24 Gene Hs.444229

mRNA Expression by UniProt/SwissProt for ARHGAP24 Gene

Q8N264-RHG24_HUMAN
Tissue specificity: Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
genes like me logo Genes that share expressions with ARHGAP24: view

Expression partners for ARHGAP24 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGAP24 Gene

Orthologs for ARHGAP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP24 35
  • 89.33 (n)
  • 94.79 (a)
ARHGAP24 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP24 35
  • 92.02 (n)
  • 95.72 (a)
ARHGAP24 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap24 35
  • 86.42 (n)
  • 93.03 (a)
Arhgap24 16
Arhgap24 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP24 35
  • 99.38 (n)
  • 99.2 (a)
ARHGAP24 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap24 35
  • 84.14 (n)
  • 90.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP24 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP24 35
  • 77.79 (n)
  • 84.58 (a)
ARHGAP24 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP24 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap24 35
  • 73.13 (n)
  • 80.22 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap24 35
  • 69.03 (n)
  • 74.18 (a)
arhgap24 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for ARHGAP24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP24 Gene

ENSEMBL:
Gene Tree for ARHGAP24 (if available)
TreeFam:
Gene Tree for ARHGAP24 (if available)

Paralogs for ARHGAP24 Gene

genes like me logo Genes that share paralogs with ARHGAP24: view

Variants for ARHGAP24 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP24 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10305 -- 86,001,034(+) TCAAT(A/T)TGTTG utr-variant-3-prime
rs13292 -- 86,000,636(-) CATTT(A/C)TTTTG reference, stop-gained
rs145115 -- 85,321,623(-) ttgcc(C/T)gcatt intron-variant
rs163732 -- 85,412,868(+) ACCTC(A/G)GCCTC intron-variant
rs168152 -- 85,418,701(+) CAGTG(A/C)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP24 Gene

Variant ID Type Subtype PubMed ID
nsv519588 CNV Gain 19592680
nsv461566 CNV Gain 19166990
nsv470048 CNV Gain 18288195
esv2425088 CNV Deletion 19546169
esv2234618 CNV Deletion 18987734
esv2727921 CNV Deletion 23290073
esv2660474 CNV Deletion 23128226
esv2509163 CNV Deletion 19546169
esv269424 CNV Insertion 20981092
esv272223 CNV Insertion 20981092
esv2228589 CNV Deletion 18987734
nsv829999 CNV Gain 17160897
esv2592051 CNV Deletion 19546169
esv3989 CNV Deletion 18987735
esv2727922 CNV Deletion 23290073
esv7427 CNV Loss 19470904
esv2665029 CNV Deletion 23128226
esv2515650 CNV Deletion 19546169
esv1939576 CNV Deletion 18987734
esv24400 CNV Loss 19812545
esv2670543 CNV Deletion 23128226
esv1208111 CNV Insertion 17803354
esv269804 CNV Insertion 20981092
esv273734 CNV Insertion 20981092
esv2727923 CNV Deletion 23290073
esv2106659 CNV Deletion 18987734
esv2727924 CNV Deletion 23290073
esv5098 CNV Deletion 18987735
esv2742711 CNV Deletion 23290073
esv274900 CNV Gain+Loss 21479260
nsv290889 CNV Loss 16902084
esv2597045 CNV Deletion 19546169
esv1993171 CNV Deletion 18987734
esv4911 CNV Deletion 18987735
esv8014 CNV Loss 19470904
esv2727925 CNV Deletion 23290073
esv1340531 CNV Deletion 17803354
nsv289665 CNV Loss 16902084
nsv526211 CNV Loss 19592680
nsv291712 CNV Loss 16902084
nsv461567 CNV Loss 19166990
nsv879517 CNV Loss 21882294
esv2676122 CNV Deletion 23128226
nsv879518 CNV Loss 21882294
nsv830000 CNV Loss 17160897
nsv470049 CNV Loss 18288195
nsv509910 CNV Loss 20534489
nsv879519 CNV Loss 21882294
esv2565886 CNV Deletion 19546169
esv2727926 CNV Deletion 23290073
nsv879520 CNV Loss 21882294
esv2727927 CNV Deletion 23290073
esv2727928 CNV Deletion 23290073

Relevant External Links for ARHGAP24 Gene

HapMap Linkage Disequilibrium report
ARHGAP24
Human Gene Mutation Database (HGMD)
ARHGAP24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP24 Gene

Disorders for ARHGAP24 Gene

Relevant External Links for ARHGAP24

Genetic Association Database (GAD)
ARHGAP24
Human Genome Epidemiology (HuGE) Navigator
ARHGAP24
genes like me logo Genes that share disorders with ARHGAP24: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ARHGAP24 Gene

Publications for ARHGAP24 Gene

  1. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23
  2. A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. (PMID: 15302923) Su Z.-J. … Gamble J.R. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton. (PMID: 15611138) Lavelin I. … Geiger B. (J. Biol. Chem. 2005) 3 4 23
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  5. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. (PMID: 16862148) Ohta Y. … Stossel T.P. (Nat. Cell Biol. 2006) 3 4

Products for ARHGAP24 Gene

Sources for ARHGAP24 Gene

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