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Aliases for ARHGAP23 Gene

Aliases for ARHGAP23 Gene

  • Rho GTPase Activating Protein 23 2 3
  • KIAA1501 4 6
  • Rho-Type GTPase-Activating Protein 23 4

External Ids for ARHGAP23 Gene

Previous GeneCards Identifiers for ARHGAP23 Gene

  • GC17P036984
  • GC17P033825
  • GC17P036584
  • GC17P032409

Summaries for ARHGAP23 Gene

Entrez Gene Summary for ARHGAP23 Gene

  • The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP23 Gene

ARHGAP23 (Rho GTPase Activating Protein 23) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity.

UniProtKB/Swiss-Prot for ARHGAP23 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP23 Gene

Genomics for ARHGAP23 Gene

Regulatory Elements for ARHGAP23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP23 Gene

38,419,286 bp from pter
38,512,392 bp from pter
93,107 bases
Plus strand

Genomic View for ARHGAP23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP23 Gene

Proteins for ARHGAP23 Gene

  • Protein details for ARHGAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 23
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ARHGAP23 Gene

    1491 amino acids
    Molecular mass:
    162192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP23 Gene


neXtProt entry for ARHGAP23 Gene

Proteomics data for ARHGAP23 Gene at MOPED

Post-translational modifications for ARHGAP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP23 Gene

No data available for DME Specific Peptides for ARHGAP23 Gene

Domains for ARHGAP23 Gene

Gene Families for ARHGAP23 Gene

  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for ARHGAP23 Gene

Suggested Antigen Peptide Sequences for ARHGAP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P227
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP23: view

Function for ARHGAP23 Gene

Molecular function for ARHGAP23 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGAP23: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP23 Gene

miRTarBase miRNAs that target ARHGAP23

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP23

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP23 Gene

Localization for ARHGAP23 Gene

Subcellular locations from

Jensen Localization Image for ARHGAP23 Gene COMPARTMENTS Subcellular localization image for ARHGAP23 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with ARHGAP23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP23 Gene

Pathways for ARHGAP23 Gene

genes like me logo Genes that share pathways with ARHGAP23: view

Pathways by source for ARHGAP23 Gene

3 Reactome pathways for ARHGAP23 Gene

Interacting Proteins for ARHGAP23 Gene

Selected Interacting proteins: Q9P227-RHG23_HUMAN for ARHGAP23 Gene via I2D

Gene Ontology (GO) - Biological Process for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP23: view

Transcripts for ARHGAP23 Gene

Unigene Clusters for ARHGAP23 Gene

Rho GTPase activating protein 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP23

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP23
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP23 Gene

No ASD Table

Relevant External Links for ARHGAP23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP23 Gene

mRNA expression in normal human tissues for ARHGAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGAP23 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP23 Gene Hs.374446

mRNA Expression by UniProt/SwissProt for ARHGAP23 Gene

Tissue specificity: Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.
genes like me logo Genes that share expressions with ARHGAP23: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGAP23 Gene

Orthologs for ARHGAP23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARHGAP23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP23 35
  • 97.32 (n)
  • 96.75 (a)
(Bos Taurus)
Mammalia ARHGAP23 35
  • 91.69 (n)
  • 93.83 (a)
(Canis familiaris)
Mammalia ARHGAP23 35
  • 91.92 (n)
  • 94.79 (a)
(Mus musculus)
Mammalia Arhgap23 35
  • 88.78 (n)
  • 93.15 (a)
Arhgap23 16
(Rattus norvegicus)
Mammalia Arhgap23 35
  • 88.44 (n)
  • 92.74 (a)
(Gallus gallus)
Aves LOC101750894 35
  • 78.79 (n)
  • 80.43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap23 35
  • 64.11 (n)
  • 63.33 (a)
(Danio rerio)
Actinopterygii LOC100006233 35
  • 60.29 (n)
  • 58.75 (a)
Species with no ortholog for ARHGAP23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP23 Gene

Gene Tree for ARHGAP23 (if available)
Gene Tree for ARHGAP23 (if available)

Paralogs for ARHGAP23 Gene

genes like me logo Genes that share paralogs with ARHGAP23: view

No data available for Paralogs for ARHGAP23 Gene

Variants for ARHGAP23 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15537 -- 38,510,786(-) TCCGG(A/G)GGGCC reference, synonymous-codon, downstream-variant-500B
rs1044757 -- 38,511,487(+) ATTGT(C/T)CCAAG utr-variant-3-prime
rs1075664 -- 38,469,821(+) ACATC(C/T)CTCAC intron-variant
rs2078135 -- 38,503,015(+) TGCAC(G/T)CCAGC intron-variant
rs2303992 -- 38,482,707(+) GGAAG(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP23 Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv469701 CNV Loss 16826518
dgv959e1 CNV Complex 17122850
nsv908191 CNV Loss 21882294
nsv908192 CNV Loss 21882294
nsv908193 CNV Loss 21882294
esv23483 CNV Gain+Loss 19812545
nsv833436 CNV Loss 17160897
esv27695 CNV Gain 19812545
nsv9549 CNV Gain 18304495

Relevant External Links for ARHGAP23 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP23 Gene

Disorders for ARHGAP23 Gene

No disorders were found for ARHGAP23 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGAP23 Gene

Publications for ARHGAP23 Gene

  1. Identification and characterization of human ARHGAP23 gene in silico. (PMID: 15254754) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3

Products for ARHGAP23 Gene

Sources for ARHGAP23 Gene

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