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ARHGAP23 Gene

protein-coding   GIFtS: 48
GCID: GC17P036584

Rho GTPase Activating Protein 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 231 2
Rho-Type GTPase-Activating Protein 232 3
KIAA15013 5
Rho GTPase-Activating Protein 232

External Ids:    HGNC: 292931   Entrez Gene: 576362   Ensembl: ENSG000002254857   OMIM: 6105905   UniProtKB: Q9P2273   

Export aliases for ARHGAP23 gene to outside databases

Previous GC identifers: GC17P036984 GC17P033825 GC17P032409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP23 Gene:
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane
receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating
proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and
Katoh, 2004 (PubMed 15254754)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARHGAP23 Gene:
ARHGAP23 (Rho GTPase activating protein 23) is a protein-coding gene. Diseases associated with ARHGAP23 include ovarian cancer, and prostatitis. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG23_HUMAN, Q9P227
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP23 gene promoter:
         c-Fos   AP-1   Fra-1   FosB   GATA-1   Arnt   PPAR-alpha   ARP-1   c-Jun   ZIC2/Zic2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARHGAP23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

ARHGAP23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP23 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P036584:  view genomic region     (about GC identifiers)

Start:
36,584,662 bp from pter      End:
36,668,628 bp from pter
Size:
83,967 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315948 212,105-296,013     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHG23_HUMAN, Q9P227 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 23  
Size: 1491 amino acids; 162192 Da
Alternative splicing: 2 isoforms:  Q9P227-1   Q9P227-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ARHGAP23: NX_Q9P227

Explore proteomics data for ARHGAP23 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001186346.1  
    ENSEMBL proteins: 
     ENSP00000393539   ENSP00000394153   ENSP00000447644   ENSP00000446960   ENSP00000463603  
     ENSP00000468573   ENSP00000447601   ENSP00000462066   ENSP00000407333  
    Reactome Protein details: Q9P227

    ARHGAP23 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGAP23

    ARHGAP23 Antibody Products:

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    Abcam antibodies for ARHGAP23
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    ARHGAP23 Assay Products:

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    Cloud-Clone Corp. ELISAs for ARHGAP23
    Cloud-Clone Corp. CLIAs for ARHGAP23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR001478 PDZ
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9P227

    ProtoNet protein and cluster: Q9P227

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG23_HUMAN, Q9P227
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG23_HUMAN, Q9P227
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    ARHGAP23 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP23
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGAP23
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGAP23

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARHGAP23:
    hsa-mir-1274b (MIRT035832)

    Block miRNA regulation of human, mouse, rat ARHGAP23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP23 (see all 43):
    hsa-miR-1197 hsa-miR-128 hsa-miR-200a hsa-miR-374a hsa-miR-138-2* hsa-miR-500a hsa-miR-141 hsa-miR-3658
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP23

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ARHGAP23 (NM_001199417)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP23
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP23

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19199708

    ARHGAP23 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP23 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP23
        Rho GTPase cycle



    ARHGAP23 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP23
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ARHGAP23 (Q9P2273 ENSP000004073334) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    RPAP1Q9BWH63, ENSP000003061234I2D: score=1 STRING: ENSP00000306123
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    WASENSP000003658914STRING: ENSP00000365891
    WASLENSP000002230234STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP23 (RHG23)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGAP23 gene (2 alternative transcripts): 
    NM_020876.1  NM_001199417.1  

    Unigene Cluster for ARHGAP23:

    Rho GTPase activating protein 23
    Hs.374446  [show with all ESTs]
    Unigene Representative Sequence: NM_001199417
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431231(uc021twd.1 uc002hqc.3) ENST00000437668(uc021twe.1)
    ENST00000582409 ENST00000549246 ENST00000548333 ENST00000581782 ENST00000578665
    ENST00000548703 ENST00000581023 ENST00000547158 ENST00000583703 ENST00000443378

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGAP23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP23 (see all 43):
    hsa-miR-1197 hsa-miR-128 hsa-miR-200a hsa-miR-374a hsa-miR-138-2* hsa-miR-500a hsa-miR-141 hsa-miR-3658
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP23
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP23 (NM_001199417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP23
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP23
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP23
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ARHGAP23
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP23
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP23

    Additional mRNA sequence: BC039190.1 

    10 DOTS entries:

    DT.92429796  DT.454892  DT.92429795  DT.92429793  DT.92429798  DT.92029612  DT.97786214  DT.120923277 
    DT.91721354  DT.91815448 

    Selected AceView cDNA sequences (see all 184):

    AI924149 CA488127 AI123323 AW297528 BM804823 AA478252 F10078 AB040934 
    BQ027932 AA351347 CN484023 AB076968 BU180944 BM548592 AI436239 AA374460 
    R56748 N98984 AI336895 AA478253 CA943274 AI924604 AI971411 BQ709351 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP23 Expression
    About this image


    ARHGAP23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    ARHGAP23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374446

    UniProtKB/Swiss-Prot: RHG23_HUMAN, Q9P227
    Tissue specificity: Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor,
    salivary gland tumor, head and neck tumor

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP23 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap231 , 5 Rho GTPase activating protein 231, 5 88.78(n)1
    93.15(a)1
      11 (60.97 cM)5
    589961  NM_021493.21  NP_067468.21 
     974155335 
    chicken
    (Gallus gallus)
    Aves LOC1017508941 rho GTPase-activating protein 23-like 78.79(n)
    80.43(a)
      101750894  XM_004950725.1  XP_004950782.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP236
    Rho GTPase activating protein 23
    64(a)
    1 ↔ 1
    6(73716023-73762282)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap231 Rho GTPase activating protein 23 64.11(n)
    63.33(a)
      100496640  XM_002940156.2  XP_002940202.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000062331 rho GTPase-activating protein 23-like 60.29(n)
    58.75(a)
      100006233  XM_005164174.1  XP_005164231.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP19D6
    RhoGAP19D
    13(a)
    1 → many
    X(20340982-20381721)
    worm
    (Caenorhabditis elegans)
    Secernentea pac-16
    Protein PAC-1, isoform c (pac-1) mRNA, complete cd...
    17(a)
    1 → many
    III(8493878-8518882) WBGene00015418


    ENSEMBL Gene Tree for ARHGAP23 (if available)
    TreeFam Gene Tree for ARHGAP23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP23 gene
    ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP92  CHN12  ARHGAP262  ARHGAP152  
    ARHGAP122  OPHN12  ARHGAP422  
    Selected SIMAP similar genes for ARHGAP23 using alignment to 8 protein entries:     RHG23_HUMAN (see all proteins) (see all similar genes):
    ARHGAP21    CYTIP    SHANK3    ARHGAP19    ARHGAP29    MAGI1
    MAST4    SLC9A3R1    ARHGAP44    MAGI2    OPHN1    SHANK2
    ARHGEF12    CHN2    MAST2    MAST3    PDZD2    ARHGAP24

    ARHGAP23 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARHGAP23
    PGOHUM00000259060 PGOHUM00000259120 PGOHUM00000259124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP23 (see all 1558)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80768991,2
    C,F,A--36582793(+) ACTCCG/ATCTCA 1 -- us2k15Minor allele frequency- A:0.33NA WA CSA 9
    rs592557411,2
    C--36582819(+) AAAAA-/AA/AAAAA
    AAAAAAAAAA
    TCCAG
    2 -- us2k1 cds11NA 2
    rs1473450371,2
    --36583003(+) TACATA/TAAATA 1 -- us2k10--------
    rs1397813991,2
    --36583087(+) CTGGGG/TCACCC 1 -- us2k10--------
    rs1911582341,2
    --36583317(+) AACTGA/TAAAAG 1 -- us2k10--------
    rs782926681,2
    C,F--36583320(+) TGAAAA/CAGTCA 1 -- us2k11Minor allele frequency- C:0.18WA 118
    rs1123194801,2
    C,F--36583384(+) TTAGAT/CAGTAG 1 -- us2k12Minor allele frequency- C:0.07CSA WA 120
    rs1414480821,2
    C--36583395(+) AAGAA-/TTTT  
            
    TTTTC
    1 -- us2k10--------
    rs1453140581,2
    --36583571(+) GTGGGC/TGGTGT 1 -- us2k10--------
    rs1162537981,2
    F--36583604(+) TACCTG/CGGGAG 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for ARHGAP23 (36584662 - 36668628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ARHGAP23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908191CNV Loss21882294
    nsv908192CNV Loss21882294
    nsv833436CNV Loss17160897
    nsv469701CNV Loss16826518
    nsv908193CNV Loss21882294
    esv27695CNV Gain19812545
    nsv9549CNV Gain18304495
    esv23483CNV Gain+Loss19812545
    dgv959e1CNV Complex17122850
    dgv957e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP23
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610590    OMIM disorders: --

    2 diseases for ARHGAP23:    
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    ovarian cancer    prostatitis


    ARHGAP23 for disorders           About GeneDecksing


    Export disorders for ARHGAP23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP23 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ARHGAP23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human ARHGAP23 gene in silico. (PubMed id 15254754)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    5. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57636 HGNC: 29293 AceView: ARHGAP23.1 Ensembl:ENSG00000225485 euGenes: HUgn57636
    ECgene: ARHGAP23 H-InvDB: ARHGAP23

    (According to HUGE)
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    HUGE: KIAA1501

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP23 gene:
    Search GeneIP for patents involving ARHGAP23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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