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ARHGAP22 Gene

protein-coding   GIFtS: 57
GCID: GC10M049654

Rho GTPase Activating Protein 22

  Search for ARHGAP22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 221 2
Rho-Type GTPase-Activating Protein 222 3
RhoGAP22
RhoGap222
Rho GTPase-Activating Protein 222
RHOGAP23

External Ids:    HGNC: 303201   Entrez Gene: 585042   Ensembl: ENSG000001288057   OMIM: 6105855   UniProtKB: Q7Z5H33   

Export aliases for ARHGAP22 gene to outside databases

Previous GC identifers: GC10M048998 GC10M049324 GC10M043918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP22 Gene:
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS
superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase
Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The
result of these interactions is regulation of cell motility. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for ARHGAP22 Gene:
ARHGAP22 (Rho GTPase activating protein 22) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3
Function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial
cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an
inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription
regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP22 gene promoter:
         C/EBPbeta   Tal-1   HNF-3beta   E47   Gfi-1   PPAR-alpha   CREB   Zic1   deltaCREB   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP22 promoter sequence
   Search Chromatin IP Primers for ARHGAP22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.23

ARHGAP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP22 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M049654:  view genomic region     (about GC identifiers)

Start:
49,654,077 bp from pter      End:
49,864,310 bp from pter
Size:
210,234 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 22  
Size: 698 amino acids; 76779 Da
Subunit: Interacts with VEZF1 (By similarity)
Secondary accessions: A0AVP7 A5YM75 B4DED8 B9EGA0 C9JDM2 O00152 Q6ZSB0
Alternative splicing: 5 isoforms:  Q7Z5H3-1   Q7Z5H3-2   Q7Z5H3-3   Q7Z5H3-4   Q7Z5H3-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP22: NX_Q7Z5H3

Explore proteomics data for ARHGAP22 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001242953.1  NP_001242954.1  NP_001242955.1  NP_067049.2  

    ENSEMBL proteins: 
     ENSP00000249601   ENSP00000422868   ENSP00000363285   ENSP00000363287   ENSP00000410054  
     ENSP00000416701   ENSP00000412461   ENSP00000422663  
    Reactome Protein details: Q7Z5H3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z5H3

    ProtoNet protein and cluster: Q7Z5H3

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG22_HUMAN, Q7Z5H3
    Function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial
    cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an
    inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription
    regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ARHGAP22           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGAP22:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    miRNA
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    hsa-mir-124-3p (MIRT022123), hsa-mir-615-3p (MIRT039842)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG22_HUMAN, Q7Z5H3: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction
    is nuclear (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARHGAP22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP22 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity


    Find genes that share SuperPaths with ARHGAP22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARHGAP22
        G-protein signaling Regulation of RAC1 activity

    1 Reactome Pathway for ARHGAP22
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP22
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP22 (Q7Z5H31, 3 ENSP000002496014) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005551, 3EBI-3866859,EBI-766279 I2D: score=1 
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ARHGDIBENSP000002289454STRING: ENSP00000228945
    ARHGDIGENSP000002194094STRING: ENSP00000219409
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP22 (RHG22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP22 gene (5 alternative transcripts): 
    NM_001256027.1  NM_001256024.1  NM_001256025.2  NM_001256026.1  NM_021226.3  

    Unigene Cluster for ARHGAP22:

    Rho GTPase activating protein 22
    Hs.655672  [show with all ESTs]
    Unigene Representative Sequence: NR_045675
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249601(uc001jgt.3 uc001jgu.3 uc010qgl.2 uc010qgm.2)
    ENST00000477708(uc001jgr.3) ENST00000374170 ENST00000374172 ENST00000417247(uc001jgs.3)
    ENST00000435790 ENST00000417912 ENST00000460425(uc001jgv.3) ENST00000515523(uc001jgw.3)
    ENST00000471013 ENST00000489984 ENST00000493012 ENST00000491108 ENST00000511570
    ENST00000464445
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      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP22

    Additional mRNA sequence: 

    AK055037.1 AK055937.1 AK097151.1 AK127586.1 AK293579.1 AY324801.1 BC047096.1 BC126444.1 
    BC136319.1 EF560749.1 NR_045675.1 U90908.1 

    12 DOTS entries:

    DT.403970  DT.100778500  DT.101981891  DT.100778501  DT.121290751  DT.434035  DT.91982854  DT.121290752 
    DT.95089100  DT.91924485  DT.121290753  DT.99968972 

    Selected AceView cDNA sequences (see all 56):

    AW513393 CR600275 BQ890110 AY324801 AL519798 NM_021226 AK055937 CA421694 
    AK097151 BE796498 BG707646 CO250008 BX283247 BQ720590 AK127586 AI754850 
    BX390118 BM972527 BI600204 BF967338 CF128657 BQ675124 BQ668648 AA781406 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP22 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                          -     -           -     -     -           -     -     -                                                               
    SP2:                          -     -           -     -     -           -     -     -                       -                                       
    SP3:                                            -     -     -                 -     -                                                               
    SP4:                                                                    -     -     -                                                               
    SP5:                    -     -     -           -     -     -     -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for ARHGAP22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP22 Expression
    About this image


    ARHGAP22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
    ARHGAP22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655672
        Custom PCR Arrays for ARHGAP22
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP22 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap221 , 5 Rho GTPase activating protein 221, 5 81.98(n)1
    84.24(a)1
      14 (20.15 cM)5
    2390271  NM_153800.41  NP_722495.31 
     332140265 
    chicken
    (Gallus gallus)
    Aves ARHGAP221 Rho GTPase activating protein 22 68.6(n)
    70.25(a)
      423779  XM_004942127.1  XP_004942184.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgap221 Rho GTPase activating protein 22 57.91(n)
    54.38(a)
      100127847  XM_004915838.1  XP_004915895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap226
    ARHGAP22 (2 of 2)6
    Rho GTPase activating protein 22
    59(a)
    56(a)
    1 ↔ many
    1 ↔ many
    13(31322377-31367135) ENSDARG00000021255
    12(2711596-2757229) ENSDARG00000076434
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAPp1906
    RhoGAPp190
    5(a)
    1 → many
    X(17533180-17546595)
    worm
    (Caenorhabditis elegans)
    Secernentea rga-56
    Protein RGA-5, isoform a (rga-5) mRNA, complete cd...
    5(a)
    1 → many
    IV(13827886-13844978) WBGene00010374


    ENSEMBL Gene Tree for ARHGAP22 (if available)
    TreeFam Gene Tree for ARHGAP22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP22 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  SRGAP32  ARHGAP352  ARHGAP442  SH3BP12  
    ARHGAP252  SRGAP22  ARHGAP42  
    9 SIMAP similar genes for ARHGAP22 using alignment to 5 protein entries:     RHG22_HUMAN (see all proteins):
    ARHGAP24    ARHGAP25    AKT2    ARHGAP21    FAM13A    ARHGAP12
    KIAA0053    FAM109A    ARHGAP9

    Find genes that share paralogs with ARHGAP22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP22 (see all 4595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107765991,2
    C,F,H--49653574(+) CAGAGG/TAGGGG 5 -- ds500113Minor allele frequency- T:0.03NS EA WA NA CSA 643
    rs1112875561,2
    C,F--49653613(+) AGGGAG/ACTGGG 5 -- ds50011Minor allele frequency- A:0.50WA 2
    rs107766001,2
    C,F,A,H--49653621(+) GGGCAC/GGCGCC 5 -- ds500110Minor allele frequency- G:0.46NA CSA WA EA 371
    rs727943981,2
    C,F--49653624(+) CAGGCG/ACCCAG 5 -- ds50016Minor allele frequency- A:0.31WA NA CSA EA 364
    rs787305071,2
    C,F--49653636(+) GTGAGG/ACATAG 5 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1487850061,2
    --49653704(+) AGTGGA/CCACAC 5 -- ds50010--------
    rs1163895131,2
    C,F--49653713(+) ACTTGC/ACCACA 5 -- ds50011Minor allele frequency- A:0.02WA 118
    rs113225571,2
    C--49653854(+) GGGGC-/GGGGGG 5 -- ds50011Minor allele frequency- G:0.00CSA 2
    rs583745071,2
    --49653854(+) GGGGCC/GGGGGG 5 -- ds50010--------
    rs755863811,2
    C--49653888(+) GGAACA/GTGCAG 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARHGAP22 (49654077 - 49864310 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ARHGAP22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6598CNV Insertion18451855
    esv1005947CNV Loss20482838
    nsv6609CNV Loss18451855
    esv25392CNV Loss19812545
    nsv895365CNV Loss21882294
    nsv516006CNV Loss19592680
    nsv895372CNV Gain21882294
    nsv895371CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv7203OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP22
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610585    OMIM disorders: --


    Find genes that share disorders with ARHGAP22           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP22
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP22 (3 documents)

    Export disorders for ARHGAP22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP22 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ARHGAP22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of conduct disorder symptomatology. (PubMed id 20585324)1, 4 Dick D.M....Bierut L. (Mol. Psychiatry 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PubMed id 15254788)1, 2 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    8. The molecular genetic architecture of self-employment. (PubMed id 23593239)1 van der Loos M.J....Thurik A.R. (PLoS ONE 2013)
    9. The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. (PubMed id 22952583)1 Hu S.H....Martin J.L. (PLoS ONE 2012)
    10. The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPI' and RhoGAP2. (PubMed id 21926414)1 Valnegri P....Sala C. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58504 HGNC: 30320 AceView: ARHGAP22 Ensembl:ENSG00000128805 euGenes: HUgn58504
    ECgene: ARHGAP22 H-InvDB: ARHGAP22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP22 gene:
    Search GeneIP for patents involving ARHGAP22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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