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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGAP22 Gene

protein-coding GIFtS: 54
GCID: GC10M049654

Rho GTPase activating protein 22

Explore 5 diseases affiliated with
ARHGAP22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 22¹ ²
RhoGAP2¹ ²
Rho-Type GTPase-Activating Protein 22² ³
RhoGap22²
Rho GTPase-Activating Protein 22²
RHOGAP2³

External Ids:	HGNC: 30320¹	Entrez Gene: 58504²	Ensembl: ENSG00000128805⁷	OMIM: 610585⁵	UniProtKB: Q7Z5H3³

Export aliases for ARHGAP22 gene to outside databases

Previous GC identifers: GC10M048998 GC10M049324 GC10M043918

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP22:

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS

superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt

and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of

these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3

Function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell

capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive

GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via

its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGAP22 gene promoter:
C/EBPbeta Tal-1 HNF-3beta E47 Gfi-1 PPAR-alpha CREB Zic1 deltaCREB En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP22 promoter sequence

Search SABiosciences Chromatin IP Primers for ARHGAP22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.23

ARHGAP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP22 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M049654: view genomic region (about GC identifiers)

Start:	49,654,077 bp from pter	End:	49,864,310 bp from pter
Size:	210,234 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 22

Size: 698 amino acids; 76779 Da

Subunit: Interacts with VEZF1 (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction is

nuclear (By similarity)

Secondary accessions: A0AVP7 A5YM75 B9EGA0 O00152 Q6ZSB0

Alternative splicing: 4 isoforms: Q7Z5H3-1 Q7Z5H3-2 Q7Z5H3-3 Q7Z5H3-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP22: NX_Q7Z5H3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z5H3

ARHGAP22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001242953.1 NP_001242954.1 NP_001242955.1 NP_067049.2

ENSEMBL proteins:

ENSP00000249601 ENSP00000422868 ENSP00000363285 ENSP00000363287 ENSP00000410054

ENSP00000416701 ENSP00000412461 ENSP00000422663

Reactome Protein details: Q7Z5H3
Human Recombinant Protein Products:

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	Uscn Proteins for ARHGAP22

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--

ARHGAP22 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP22 for domains About GeneDecksing

4 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q7Z5H3

ProtoNet protein and cluster: Q7Z5H3

2 Blocks protein families:

IPB000198 RhoGAP domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3

Similarity: Contains 1 PH domain

Similarity: Contains 1 Rho-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RHG22_HUMAN, Q7Z5H3

Function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell

capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive

GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via

its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: ARHGAP22 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP22

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005543	phospholipid binding	IEA	--

ARHGAP22 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARHGAP22:

Increased HPV18 LCR reporter a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Regulation of RAC1 activity

G-protein signaling Regulation of RAC1 activity

1.00

G-protein signaling_Regulation of RAC1 activity

0.88

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ARHGAP22

G-protein signaling Regulation of RAC1 activity

1 GeneGo (Thomson Reuters) Pathway for ARHGAP22

G-protein signaling Regulation of RAC1 activity

3 Reactome Pathways for ARHGAP22

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

ARHGAP22 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP22

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for ARHGAP22 (Q7Z5H3^{1, 3} ENSP00000249601⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNA1A	O00555¹^,³	EBI-3866859,EBI-766279 I2D: score=1
ARHGAP4	ENSP00000203786⁴	STRING: ENSP00000203786
ARHGEF2	ENSP00000315325⁴	STRING: ENSP00000315325
FGD1	ENSP00000364277⁴	STRING: ENSP00000364277
RHOU	ENSP00000355652⁴	STRING: ENSP00000355652

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--

ARHGAP22 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGAP22
Search CenterWatch for drugs/clinical trials and news about ARHGAP22 / RHG22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARHGAP22 gene (5 alternative transcripts):

NM_001256027.1 NM_001256024.1 NM_001256025.2 NM_001256026.1 NM_021226.3

Unigene Cluster for ARHGAP22:

Rho GTPase activating protein 22

Hs.655672 [show with all ESTs]

Unigene Representative Sequence: NR_045675

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000249601(uc001jgt.3 uc001jgu.3 uc010qgl.2 uc010qgm.2)

ENST00000477708(uc001jgr.3) ENST00000374170 ENST00000374172 ENST00000417247(uc001jgs.3)

ENST00000435790 ENST00000417912 ENST00000460425(uc001jgv.3) ENST00000515523(uc001jgw.3)

ENST00000471013 ENST00000489984 ENST00000493012 ENST00000491108 ENST00000511570

ENST00000464445

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Additional cDNA sequence:

AK055037.1 AK055937.1 AK097151.1 AK127586.1 AK293579.1 AY324801.1 BC047096.1 BC126444.1

BC136319.1 EF560749.1 NR_045675.1 U90908.1

12 DOTS entries:

DT.403970 DT.100778500 DT.101981891 DT.100778501 DT.121290751 DT.434035 DT.91982854 DT.121290752

DT.95089100 DT.91924485 DT.121290753 DT.99968972

24/56 AceView cDNA sequences (see all 56):

AL519798 AK097151 BQ890110 NM_021226 CA421694 AK055937 AW513393 AY324801

CR600275 BQ668648 BX283247 AI754850 AA937220 BC037890 CO250008 BC047096

AA781406 BI550967 BI600204 BX283222 CA448170 BG325672 U90908 AK127586

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP22 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b
SP1:									-		-				-		-		-				-		-		-
SP2:									-		-				-		-		-				-		-		-								-
SP3:															-		-		-						-		-
SP4:																							-		-		-
SP5:							-		-		-				-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for ARHGAP22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGAP22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ARHGAP22 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARHGAP22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP22

SOURCE GeneReport for Unigene cluster: Hs.655672

SABiosciences Custom PCR Arrays for ARHGAP22

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP22

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ARHGAP22 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Arhgap22^{1 , 5}	Rho GTPase activating protein 22^{1, 5}	82.25(n)¹ 84.66(a)¹		14 (20.15 cM)⁵ 239027¹ NM_153800.4¹ NP_722495.3¹ 33214026⁵
chicken (Gallus gallus)	Aves	ARHGAP22¹	Rho GTPase activating protein 22	68.43(n) 70.34(a)		423779 XM_421651.3 XP_421651.2
zebrafish (Danio rerio)	Actinopterygii	arhgap22⁶ CR774192.3⁶	--	56(a) 52(a)	many → 1 many → 1	13(31322377-31367135) 12(2711674-2761051)

ENSEMBL Gene Tree for ARHGAP22 (if available)
TreeFam Gene Tree for ARHGAP22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGAP22 gene

SRGAP1² ARHGAP5² ARHGAP17² ARHGAP24² ARHGAP35² SRGAP3² ARHGAP44² SH3BP1²

ARHGAP4² SRGAP2² ARHGAP25²

9 SIMAP similar genes for ARHGAP22 using alignment to 6 protein entries: RHG22_HUMAN (see all proteins):

ARHGAP24 ARHGAP25 AKT2 ARHGAP21 FAM13A KIAA0053

ARHGAP12 FAM109A ARHGAP9

ARHGAP22 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10776599^1,2	C,F,H,	--	49653574(+)	`CAGAGG/TAGGGG`	5	--	ds500¹		13		NS EA WA NA CSA	643
rs111287556^1,2	C,	--	49653613(+)	`AGGGAG/ACTGGG`	5	--	ds500¹		1		WA	2
rs10776600^1,2	C,F,A,H,	--	49653621(+)	`GGGCAC/GGCGCC`	5	--	ds500¹		10		NA CSA WA EA	371
rs72794398^1,2	C,F,	--	49653624(+)	`CAGGCG/ACCCAG`	5	--	ds500¹		6		WA NA CSA EA	364
rs78730507^1,2	F,	--	49653636(+)	`GTGAGG/ACATAG`	5	--	ds500¹		1		EA	120
rs148785006^1,2		--	49653704(+)	`AGTGGA/CCACAC`	5	--	ds500¹		0	--	--	--	--
rs116389513^1,2	F,	--	49653713(+)	`ACTTGC/ACCACA`	5	--	ds500¹		1		WA	118
rs11322557^1,2	C,	--	49653854(+)	`GGGGC-/GGGGGG`	5	--	ds500¹		1		CSA	2
rs58374507^1,2		--	49653854(+)	`GGGGCC/GGGGGG`	5	--	ds500¹		0	--	--	--	--
rs75586381^1,2		--	49653888(+)	`GGAACA/GTGCAG`	5	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARHGAP22 (49654077 - 49864310 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ARHGAP22
1 CNV: 48558
2 Indels: 48559 71003

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP22

DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARHGAP22 for disorders           About GeneDecksing

OMIM gene information: 610585    OMIM disorders: --

5 diseases for ARHGAP22:    About MalaCards

conduct disorder macular degeneration diabetic retinopathy alzheimer's disease

ataxia

Human Genome Epidemiology (HuGE) Navigator: ARHGAP22 (3 documents)

Export disorders for ARHGAP22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ARHGAP22 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ARHGAP22)

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Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PubMed id 15254788)^{1, 2} Katoh M. and Katoh M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)^{1, 3} Andersson B.... Gibbs R.A. (1996)
The weak complex between RhoGAP protein ARHGAP22 and s ignal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide bindi ng mode. (PubMed id 22952583)¹ Hu S.H....Martin J.L. (2012)
Genome-wide association study of diabetic retinopathy in a Taiwanese population. (PubMed id 21310492)¹ Huang Y.C....Tsai F.J. (2011)
The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPd and RhoGAP2. (PubMed id 21926414)¹ Valnegri P....Sala C. (2011)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
Identification of RhoGAP22 as an Akt-dependent regula tor of cell motility in response to insulin. (PubMed id 21969604)¹ Rowland A.F....James D.E. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 58504	HGNC: 30320	AceView: ARHGAP22	Ensembl:ENSG00000128805	euGenes: HUgn58504
ECgene: ARHGAP22	H-InvDB: ARHGAP22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ARHGAP22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARHGAP22 gene
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Patent Information for ARHGAP22 gene:
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ARHGAP22 Gene

Rho GTPase activating protein 22

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ARHGAP22 Gene

Rho GTPase activating protein 22

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