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Aliases for ARHGAP22 Gene

Aliases for ARHGAP22 Gene

  • Rho GTPase Activating Protein 22 2 3 5
  • Rho-Type GTPase-Activating Protein 22 3 4
  • RhoGAP2 3 4
  • RhoGap22 3

External Ids for ARHGAP22 Gene

Previous GeneCards Identifiers for ARHGAP22 Gene

  • GC10M048998
  • GC10M049324
  • GC10M049654
  • GC10M043918
  • GC10M048446

Summaries for ARHGAP22 Gene

Entrez Gene Summary for ARHGAP22 Gene

  • This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ARHGAP22 Gene

ARHGAP22 (Rho GTPase Activating Protein 22) is a Protein Coding gene. Diseases associated with ARHGAP22 include duane retraction syndrome 2. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP22 Gene

  • Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP22 Gene

Genomics for ARHGAP22 Gene

Regulatory Elements for ARHGAP22 Gene

Promoters for ARHGAP22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP22 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP22 Gene

Chromosome:
10
Start:
48,430,318 bp from pter
End:
48,656,265 bp from pter
Size:
225,948 bases
Orientation:
Minus strand

Genomic View for ARHGAP22 Gene

Genes around ARHGAP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP22 Gene

Proteins for ARHGAP22 Gene

  • Protein details for ARHGAP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H3-RHG22_HUMAN
    Recommended name:
    Rho GTPase-activating protein 22
    Protein Accession:
    Q7Z5H3
    Secondary Accessions:
    • A0AVP7
    • A5YM75
    • B4DED8
    • B9EGA0
    • C9JDM2
    • O00152
    • Q6ZSB0

    Protein attributes for ARHGAP22 Gene

    Size:
    698 amino acids
    Molecular mass:
    76779 Da
    Quaternary structure:
    • Interacts with VEZF1.

    Alternative splice isoforms for ARHGAP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP22 Gene

Proteomics data for ARHGAP22 Gene at MOPED

Post-translational modifications for ARHGAP22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ARHGAP22 Gene

Domains & Families for ARHGAP22 Gene

Protein Domains for ARHGAP22 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5H3

UniProtKB/Swiss-Prot:

RHG22_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP22: view

Function for ARHGAP22 Gene

Molecular function for ARHGAP22 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,TAS --
genes like me logo Genes that share ontologies with ARHGAP22: view
genes like me logo Genes that share phenotypes with ARHGAP22: view

Animal Models for ARHGAP22 Gene

MGI Knock Outs for ARHGAP22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP22 Gene

Localization for ARHGAP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP22 Gene COMPARTMENTS Subcellular localization image for ARHGAP22 gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ARHGAP22 Gene

Pathways & Interactions for ARHGAP22 Gene

genes like me logo Genes that share pathways with ARHGAP22: view

Pathways by source for ARHGAP22 Gene

3 Reactome pathways for ARHGAP22 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP22 Gene

Gene Ontology (GO) - Biological Process for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030154 cell differentiation IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP22: view

No data available for SIGNOR curated interactions for ARHGAP22 Gene

Drugs & Compounds for ARHGAP22 Gene

No Compound Related Data Available

Transcripts for ARHGAP22 Gene

Unigene Clusters for ARHGAP22 Gene

Rho GTPase activating protein 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ARHGAP22 Gene

GeneLoc Exon Structure for
ARHGAP22
ECgene alternative splicing isoforms for
ARHGAP22

Expression for ARHGAP22 Gene

mRNA expression in normal human tissues for ARHGAP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP22 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8) and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGAP22 Gene

This gene is overexpressed in Heart (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP22 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP22 Gene Hs.655672

genes like me logo Genes that share expression patterns with ARHGAP22: view

Protein tissue co-expression partners for ARHGAP22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP22 Gene

Orthologs for ARHGAP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP22 36
  • 98 (a)
OneToOne
ARHGAP22 35
  • 99.01 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia ARHGAP22 36
  • 85 (a)
OneToOne
ARHGAP22 35
  • 87.53 (n)
  • 87.2 (a)
dog
(Canis familiaris)
Mammalia ARHGAP22 35
  • 83.64 (n)
  • 79.54 (a)
ARHGAP22 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap22 16
Arhgap22 35
  • 81.98 (n)
  • 84.24 (a)
Arhgap22 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP22 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP22 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap22 35
  • 77.7 (n)
  • 78.62 (a)
chicken
(Gallus gallus)
Aves ARHGAP22 35
  • 68.6 (n)
  • 70.25 (a)
ARHGAP22 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap22 35
  • 57.91 (n)
  • 54.38 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap22 36
  • 59 (a)
OneToMany
ARHGAP22 (2 of 2) 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ARHGAP22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP22 Gene

ENSEMBL:
Gene Tree for ARHGAP22 (if available)
TreeFam:
Gene Tree for ARHGAP22 (if available)

Paralogs for ARHGAP22 Gene

(9) SIMAP similar genes for ARHGAP22 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGAP22: view

Variants for ARHGAP22 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP22 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1867586 - 48,450,900(+) GCCCC(A/G/T)TGGGG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs3747853 - 48,450,295(+) CTGGC(A/G)GCACA intron-variant, nc-transcript-variant, reference, missense
rs754368 -- 48,448,664(-) TGTCC(C/T)GTCCA intron-variant
rs1051507 -- 48,446,360(-) ACCAC(A/G)TCTGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1078261 -- 48,553,916(-) GGGGA(C/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP22 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv895372 CNV Gain 21882294
esv1005947 CNV Loss 20482838
nsv516006 CNV Loss 19592680
nsv6598 CNV Insertion 18451855
nsv6609 CNV Loss 18451855
esv25392 CNV Loss 19812545

Variation tolerance for ARHGAP22 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP22 Gene

HapMap Linkage Disequilibrium report
ARHGAP22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Disorders for ARHGAP22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP22 Gene - From: OMIM

Disorder Aliases PubMed IDs
duane retraction syndrome 2
  • durs2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP22

Genetic Association Database (GAD)
ARHGAP22
Human Genome Epidemiology (HuGE) Navigator
ARHGAP22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP22
genes like me logo Genes that share disorders with ARHGAP22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP22 Gene

Publications for ARHGAP22 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 48 67
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The molecular genetic architecture of self-employment. (PMID: 23593239) van der Loos M.J. … Thurik A.R. (PLoS ONE 2013) 3
  5. The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. (PMID: 22952583) Hu S.H. … Martin J.L. (PLoS ONE 2012) 3

Products for ARHGAP22 Gene

Sources for ARHGAP22 Gene

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