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Aliases for ARHGAP22 Gene

Aliases for ARHGAP22 Gene

  • Rho GTPase Activating Protein 22 2 3
  • Rho-Type GTPase-Activating Protein 22 3 4
  • RhoGAP2 3 4
  • Rho GTPase-Activating Protein 22 3
  • RhoGap22 3

External Ids for ARHGAP22 Gene

Previous GeneCards Identifiers for ARHGAP22 Gene

  • GC10M048998
  • GC10M049324
  • GC10M049654
  • GC10M043918

Summaries for ARHGAP22 Gene

Entrez Gene Summary for ARHGAP22 Gene

  • This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ARHGAP22 Gene

ARHGAP22 (Rho GTPase Activating Protein 22) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP22 Gene

  • Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP22 Gene

Genomics for ARHGAP22 Gene

Regulatory Elements for ARHGAP22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP22 Gene

Start:
48,446,025 bp from pter
End:
48,656,265 bp from pter
Size:
210,241 bases
Orientation:
Minus strand

Genomic View for ARHGAP22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP22 Gene

Proteins for ARHGAP22 Gene

  • Protein details for ARHGAP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H3-RHG22_HUMAN
    Recommended name:
    Rho GTPase-activating protein 22
    Protein Accession:
    Q7Z5H3
    Secondary Accessions:
    • A0AVP7
    • A5YM75
    • B4DED8
    • B9EGA0
    • C9JDM2
    • O00152
    • Q6ZSB0

    Protein attributes for ARHGAP22 Gene

    Size:
    698 amino acids
    Molecular mass:
    76779 Da
    Quaternary structure:
    • Interacts with VEZF1.

    Alternative splice isoforms for ARHGAP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP22 Gene

Proteomics data for ARHGAP22 Gene at MOPED

Post-translational modifications for ARHGAP22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP22 Gene

Domains for ARHGAP22 Gene

Gene Families for ARHGAP22 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for ARHGAP22 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5H3

UniProtKB/Swiss-Prot:

RHG22_HUMAN :
  • Q7Z5H3
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP22: view

Function for ARHGAP22 Gene

Molecular function for ARHGAP22 Gene

UniProtKB/Swiss-Prot Function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with ARHGAP22: view

Phenotypes for ARHGAP22 Gene

GenomeRNAi human phenotypes for ARHGAP22:
genes like me logo Genes that share phenotypes with ARHGAP22: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP22 Gene

miRTarBase miRNAs that target ARHGAP22

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP22 Gene

Localization for ARHGAP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP22 Gene COMPARTMENTS Subcellular localization image for ARHGAP22 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ARHGAP22: view

Pathways for ARHGAP22 Gene

genes like me logo Genes that share pathways with ARHGAP22: view

Pathways by source for ARHGAP22 Gene

3 Reactome pathways for ARHGAP22 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP22 Gene

Gene Ontology (GO) - Biological Process for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP22: view

Transcripts for ARHGAP22 Gene

Unigene Clusters for ARHGAP22 Gene

Rho GTPase activating protein 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP22

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ARHGAP22 Gene

GeneLoc Exon Structure for
ARHGAP22
ECgene alternative splicing isoforms for
ARHGAP22

Expression for ARHGAP22 Gene

mRNA expression in normal human tissues for ARHGAP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP22 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.8) and Brain - Substantia nigra (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP22 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP22 Gene Hs.655672

genes like me logo Genes that share expressions with ARHGAP22: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP22 Gene

Orthologs for ARHGAP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP22 35
  • 99.01 (n)
  • 99.4 (a)
ARHGAP22 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP22 35
  • 87.53 (n)
  • 87.2 (a)
ARHGAP22 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP22 35
  • 83.64 (n)
  • 79.54 (a)
ARHGAP22 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap22 35
  • 81.98 (n)
  • 84.24 (a)
Arhgap22 16
Arhgap22 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP22 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP22 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap22 35
  • 77.7 (n)
  • 78.62 (a)
chicken
(Gallus gallus)
Aves ARHGAP22 35
  • 68.6 (n)
  • 70.25 (a)
ARHGAP22 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap22 35
  • 57.91 (n)
  • 54.38 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap22 36
  • 59 (a)
OneToMany
ARHGAP22 (2 of 2) 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for ARHGAP22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP22 Gene

ENSEMBL:
Gene Tree for ARHGAP22 (if available)
TreeFam:
Gene Tree for ARHGAP22 (if available)

Paralogs for ARHGAP22 Gene

Selected SIMAP similar genes for ARHGAP22 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGAP22: view

Variants for ARHGAP22 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP22 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs747532 -- 48,548,317(-) GGTTG(A/G)AGCAG intron-variant
rs747533 -- 48,548,213(-) GCAAG(C/T)GGCTG intron-variant
rs749377 -- 48,553,358(+) TGTGC(C/T)TGAGA intron-variant
rs753342 -- 48,456,578(-) AGTCT(C/T)TTGCG intron-variant
rs754368 -- 48,448,664(-) TGTCC(C/T)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP22 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv895372 CNV Gain 21882294
esv1005947 CNV Loss 20482838
nsv516006 CNV Loss 19592680
nsv6598 CNV Insertion 18451855
nsv6609 CNV Loss 18451855
esv25392 CNV Loss 19812545

Relevant External Links for ARHGAP22 Gene

HapMap Linkage Disequilibrium report
ARHGAP22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Disorders for ARHGAP22 Gene

Relevant External Links for ARHGAP22

Genetic Association Database (GAD)
ARHGAP22
Human Genome Epidemiology (HuGE) Navigator
ARHGAP22
genes like me logo Genes that share disorders with ARHGAP22: view

No data available for UniProtKB/Swiss-Prot for ARHGAP22 Gene

Publications for ARHGAP22 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 3 4

Products for ARHGAP22 Gene

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