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Aliases for ARHGAP21 Gene

Aliases for ARHGAP21 Gene

  • Rho GTPase Activating Protein 21 2 3 5
  • Rho-Type GTPase-Activating Protein 21 3 4
  • Rho GTPase-Activating Protein 10 3 4
  • ARHGAP10 3 4
  • Rho-GTPase Activating Protein 10 3
  • KIAA1424 4

External Ids for ARHGAP21 Gene

Previous GeneCards Identifiers for ARHGAP21 Gene

  • GC10M024876
  • GC10M024912
  • GC10M024873

Summaries for ARHGAP21 Gene

Entrez Gene Summary for ARHGAP21 Gene

  • ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP21 Gene

ARHGAP21 (Rho GTPase Activating Protein 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP9.

UniProtKB/Swiss-Prot for ARHGAP21 Gene

  • Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP21 Gene

Genomics for ARHGAP21 Gene

Regulatory Elements for ARHGAP21 Gene

Promoters for ARHGAP21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP21 Gene

Chromosome:
10
Start:
24,583,609 bp from pter
End:
24,723,668 bp from pter
Size:
140,060 bases
Orientation:
Minus strand

Genomic View for ARHGAP21 Gene

Genes around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP21 Gene

Proteins for ARHGAP21 Gene

  • Protein details for ARHGAP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5U3-RHG21_HUMAN
    Recommended name:
    Rho GTPase-activating protein 21
    Protein Accession:
    Q5T5U3
    Secondary Accessions:
    • Q0VF98
    • Q7Z3P7
    • Q8N3A2
    • Q8NI19
    • Q8TBV5
    • Q9P2C3

    Protein attributes for ARHGAP21 Gene

    Size:
    1957 amino acids
    Molecular mass:
    217331 Da
    Quaternary structure:
    • Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1.
    Miscellaneous:
    • Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.
    • Required for In1A-dependent entry of Listeria monocytogenes into cells.

    Three dimensional structures from OCA and Proteopedia for ARHGAP21 Gene

    Alternative splice isoforms for ARHGAP21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP21 Gene

Proteomics data for ARHGAP21 Gene at MOPED

Post-translational modifications for ARHGAP21 Gene

  • Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP21 Gene

No data available for DME Specific Peptides for ARHGAP21 Gene

Domains & Families for ARHGAP21 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T5U3

UniProtKB/Swiss-Prot:

RHG21_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP21: view

Function for ARHGAP21 Gene

Molecular function for ARHGAP21 Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon cell differentiation.

Phenotypes for ARHGAP21 Gene

genes like me logo Genes that share phenotypes with ARHGAP21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP21 Gene

Localization for ARHGAP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP21 Gene COMPARTMENTS Subcellular localization image for ARHGAP21 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0030054 cell junction IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP21: view

Pathways & Interactions for ARHGAP21 Gene

genes like me logo Genes that share pathways with ARHGAP21: view

Pathways by source for ARHGAP21 Gene

Gene Ontology (GO) - Biological Process for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IBA --
GO:0051683 establishment of Golgi localization IDA 20525016
GO:0051684 maintenance of Golgi location IMP 20525016
genes like me logo Genes that share ontologies with ARHGAP21: view

No data available for SIGNOR curated interactions for ARHGAP21 Gene

Drugs & Compounds for ARHGAP21 Gene

(2) Drugs for ARHGAP21 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0
genes like me logo Genes that share compounds with ARHGAP21: view

Transcripts for ARHGAP21 Gene

Unigene Clusters for ARHGAP21 Gene

Rho GTPase activating protein 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ARHGAP21 Gene

GeneLoc Exon Structure for
ARHGAP21
ECgene alternative splicing isoforms for
ARHGAP21

Expression for ARHGAP21 Gene

mRNA expression in normal human tissues for ARHGAP21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP21 Gene

This gene is overexpressed in Plasma (29.4) and Fetal Brain (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP21 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP21 Gene Hs.524195

mRNA Expression by UniProt/SwissProt for ARHGAP21 Gene

Q5T5U3-RHG21_HUMAN
Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
genes like me logo Genes that share expression patterns with ARHGAP21: view

Protein tissue co-expression partners for ARHGAP21 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGAP21 Gene

Orthologs for ARHGAP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP21 36
  • 99 (a)
OneToOne
ARHGAP21 35
  • 99.52 (n)
  • 99.49 (a)
cow
(Bos Taurus)
Mammalia ARHGAP21 36
  • 87 (a)
OneToOne
ARHGAP21 35
  • 84.96 (n)
  • 87.3 (a)
dog
(Canis familiaris)
Mammalia ARHGAP21 35
  • 85.65 (n)
  • 87.09 (a)
ARHGAP21 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap21 36
  • 87 (a)
OneToOne
Arhgap21 16
Arhgap21 35
  • 83.99 (n)
  • 87.28 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP21 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP21 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap21 35
  • 83.32 (n)
  • 86.89 (a)
chicken
(Gallus gallus)
Aves ARHGAP21 35
  • 75.08 (n)
  • 74.87 (a)
ARHGAP21 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP21 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rGAP 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap21 35
  • 67.44 (n)
  • 65.09 (a)
Str.595 35
zebrafish
(Danio rerio)
Actinopterygii arhgap21a 36
  • 50 (a)
OneToMany
arhgap21b 36
  • 54 (a)
OneToMany
arhgap21b 35
  • 59.47 (n)
  • 57.86 (a)
wufe14a09 35
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP19D 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pac-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9299 36
  • 48 (a)
OneToMany
Species with no ortholog for ARHGAP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP21 Gene

ENSEMBL:
Gene Tree for ARHGAP21 (if available)
TreeFam:
Gene Tree for ARHGAP21 (if available)

Paralogs for ARHGAP21 Gene

Pseudogenes.org Pseudogenes for ARHGAP21 Gene

genes like me logo Genes that share paralogs with ARHGAP21: view

Variants for ARHGAP21 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP21 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3748222 - 24,619,757(+) CTTGA(C/T)TCCTT nc-transcript-variant, reference, missense
rs1133897 - 24,585,509(-) CTGCT(A/G)CATAC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1143051 - 24,585,457(-) ATCCG(C/T)GGCAG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1143057 - 24,585,404(-) TCAGT(A/G)AAGGG reference, missense, utr-variant-3-prime
rs1143075 - 24,585,110(-) AAGAA(A/G)CACCT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP21 Gene

Variant ID Type Subtype PubMed ID
nsv6099 CNV Insertion 18451855
esv2734095 CNV Deletion 23290073
esv2666299 CNV Deletion 23128226

Variation tolerance for ARHGAP21 Gene

Residual Variation Intolerance Score: 3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP21 Gene

HapMap Linkage Disequilibrium report
ARHGAP21
Human Gene Mutation Database (HGMD)
ARHGAP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Disorders for ARHGAP21 Gene

Relevant External Links for ARHGAP21

Genetic Association Database (GAD)
ARHGAP21
Human Genome Epidemiology (HuGE) Navigator
ARHGAP21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP21

No disorders were found for ARHGAP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP21 Gene

Publications for ARHGAP21 Gene

  1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PMID: 12056806) Basseres D.S. … Saad S.T.O. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. Genetic association of ARHGAP21 gene variant with mandibular prognathism. (PMID: 25691070) Perillo L. … Nigro V. (J. Dent. Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. ARHGAP21 protein, a new partner of I+-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition. (PMID: 23235160) Barcellos K.S. … Saad S.T. (J. Biol. Chem. 2013) 3

Products for ARHGAP21 Gene

Sources for ARHGAP21 Gene

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