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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP21 Gene

protein-coding   GIFtS: 52
GCID: GC10M024873

Rho GTPase Activating Protein 21

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 211 2     KIAA14243 5
Rho GTPase-Activating Protein 102 3     Rho GTPase-Activating Protein 212
Rho-Type GTPase-Activating Protein 212 3     Rho-GTPase Activating Protein 102
ARHGAP102 3     

External Ids:    HGNC: 237251   Entrez Gene: 575842   Ensembl: ENSG000001078637   OMIM: 6098705   UniProtKB: Q5T5U33   

Export aliases for ARHGAP21 gene to outside databases

Previous GC identifers: GC10M024876 GC10M024912 GC10M024534


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP21 Gene:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the
ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al.,
2005 (PubMed 15793564)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARHGAP21 Gene: 
ARHGAP21 (Rho GTPase activating protein 21) is a protein-coding gene. Diseases associated with ARHGAP21 include influenza, and glioblastoma. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP27.

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP21 gene promoter:
         LHX3b/Lhx3b   NF-1   AML1a   GATA-3   GATA-1   GATA-2   S8   LHX3a/Lhx3a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP21 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.3   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.31

ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP21 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M024873:  view genomic region     (about GC identifiers)

Start:
24,872,538 bp from pter      End:
25,012,597 bp from pter
Size:
140,060 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 21  
Size: 1957 amino acids; 217331 Da
Subunit: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle
membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on
interaction with GTP-bound ARF1
Miscellaneous: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers
Miscellaneous: Required for In1A-dependent entry of Listeria monocytogenes into cells
3 PDB 3D structures from and Proteopedia for ARHGAP21:
2DHJ (3D)        2J59 (3D)        2YUY (3D)    
Secondary accessions: Q0VF98 Q7Z3P7 Q8N3A2 Q8NI19 Q8TBV5 Q9P2C3
Alternative splicing: 2 isoforms:  Q5T5U3-1   Q5T5U3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP21: NX_Q5T5U3

Explore proteomics data for ARHGAP21 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T5U3

  • ARHGAP21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP21 Protein Expression
    REFSEQ proteins: NP_065875.3  
    ENSEMBL proteins: 
     ENSP00000379709   ENSP00000389940   ENSP00000402761   ENSP00000365592   ENSP00000405018  
     ENSP00000400566   ENSP00000365604  

    Human Recombinant Protein Products for ARHGAP21: 
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    Cloud-Clone Corp. Proteins for ARHGAP21 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005794Golgi apparatus IDA--
    GO:0005856cytoskeleton IEA--
    GO:0030054cell junction IEA--

    ARHGAP21 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR001478 PDZ
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q5T5U3

    ProtoNet protein and cluster: Q5T5U3

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001605 Spectrin pleckstrin homology domain signature


    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG21_HUMAN, Q5T5U3
    Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
    control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions
    Induction: Up-regulated upon cell differentiation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI17347647
    GO:0005543phospholipid binding IEA--
         
    ARHGAP21 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP21 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/42 Interacting proteins for ARHGAP21 (Q5T5U31, 2, 3 ENSP000003797094) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974844 I2D: score=2 
    EEF1DP296921, 3EBI-1642518,EBI-358607 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-3295618 I2D: score=1 STRING: ENSP00000309503
    ARF1P840773, ENSP000002721024I2D: score=2 STRING: ENSP00000272102
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization IMP--
    GO:0007165signal transduction IEA--
    GO:0051683establishment of Golgi localization IDA--
    GO:0051684maintenance of Golgi location IMP--
    GO:0072384organelle transport along microtubule IMP--

    ARHGAP21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP21 (RHG21)

    1 HMDB Compound for ARHGAP21    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARHGAP21 / RHG21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP21 gene: 
    NM_020824.3  

    Unigene Cluster for ARHGAP21:

    Rho GTPase activating protein 21
    Hs.524195  [show with all ESTs]
    Unigene Representative Sequence: NM_020824
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396432(uc010qdb.1 uc001isb.2) ENST00000486374 ENST00000477190
    ENST00000418033 ENST00000482792 ENST00000418325 ENST00000376410(uc010qdc.1)
    ENST00000446003(uc009xkl.1 uc001isc.1) ENST00000493154 ENST00000476067
    ENST00000483114 ENST00000476499(uc001isd.1) ENST00000416305 ENST00000472150
    ENST00000463892 ENST00000320481

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    Additional mRNA sequence: 

    AB037845.2 AF480466.1 AK090642.1 AK295649.1 AK297278.1 AK307604.1 AL834495.1 BC022931.1 
    BC118915.2 

    18 DOTS entries:

    DT.444446  DT.99962095  DT.121291442  DT.91952775  DT.121343937  DT.91897476  DT.121343936  DT.92419733 
    DT.121291398  DT.121364000  DT.40273675  DT.100656762  DT.100710705  DT.95207218  DT.99938162  DT.121291470 
    DT.121306615  DT.453753 

    24/242 AceView cDNA sequences (see all 242):

    AA973435 BQ959956 AA599905 BQ028243 BV174396 AV709848 AA527538 CF144610 
    AA568361 BM913455 AB037845 AW001808 BM719318 AA236188 BE856005 AL701494 
    BE858783 BP363533 AW593794 CA413503 BE550507 AI081012 AW137580 AI160830 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:        -     -                 -                                   -     -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                -                                   -     -     -                                                                           
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:                    -                 -               
    SP2:                    -                 -               
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ARHGAP21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP21 Expression
    About this image


    See ARHGAP21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP21

    SOURCE GeneReport for Unigene cluster: Hs.524195

    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP21 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap211 , 5 Rho GTPase activating protein 211, 5 84(n)1
    87.28(a)1
      2 (14.60 cM)5
    714351  NM_001128084.21  NP_001121556.21 
     208479195 
    chicken
    (Gallus gallus)
    Aves ARHGAP211 Rho GTPase activating protein 21 75.06(n)
    74.87(a)
      420500  NM_001177357.1  NP_001170828.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP216
    Rho GTPase activating protein 21
    68(a)
    1 ↔ 1
    6(15289129-15419344)
    African clawed frog
    (Xenopus laevis)
    Amphibia rGAP2 rho-GTPase activating protein 76.85(n)    AF462392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe14a092 Transcribed sequence with weak similarity to protein refNP_067468.1 (M.musculus) hypothetical protein, MNCb-1301 [Mus musculus] less 76.03(n)    AL922797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP19D6
    RhoGAP19D
    18(a)
    1 → many
    X(20340982-20381721)
    worm
    (Caenorhabditis elegans)
    Secernentea pac-16
    GTPase-activating protein pac-1
    19(a)
    1 → many
    III(8493878-8518882)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BEM26
    Rho GTPase activating protein (RhoGAP) involved in...
    7(a)
    1 → many
    V(476345-482848)


    ENSEMBL Gene Tree for ARHGAP21 (if available)
    TreeFam Gene Tree for ARHGAP21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP21 gene
    ARHGAP272  ARHGAP322  ARHGAP102  CHN22  ARHGAP232  ARHGAP332  ARHGAP92  ARHGAP262  
    CHN12  ARHGAP302  ARHGAP152  ARHGAP122  OPHN12  ARHGAP422  ARHGAP312  
    18/38 SIMAP similar genes for ARHGAP21 using alignment to 8 protein entries:     RHG21_HUMAN (see all proteins) (see all similar genes):
    ARHGAP23    ARHGAP6    OPHN1    SYDE1    SRGAP1    ARHGAP19
    ARHGAP10    ARHGAP27    ARHGAP24    ARHGAP5    SRGAP2    ARHGAP12
    HMHA1    ARHGAP4    ARHGAP22    ARHGAP44    CHN1    ARHGAP26

    ARHGAP21 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARHGAP21
    PGOHUM00000248722 PGOHUM00000260133 PGOHUM00000260134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2777 SNPs in ARHGAP21 are shown (see all 2777)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0351914
    ----see VAR_0351912 A T mis40--------
    rs1833137141,2
    --24872041(+) TCAGCC/TTTAAC 1 -- int10--------
    rs118159131,2
    C,H--24872179(+) gttacT/Cgtaac 1 -- int11Minor allele frequency- C:0.25NA 4
    rs1484705781,2
    --24872217(+) AGAGAA/CGTTAA 1 -- int10--------
    rs118159631,2
    C,F,H--24872478(+) AATCAT/CGTAAG 1 -- int15Minor allele frequency- C:0.18NA WA CSA 215
    rs1452978441,2
    --24872645(+) TTCTCA/GATAAA 1 -- ut310--------
    rs32109161,2
    --24872860(-) ACTTCC/AATTCT 1 -- ut313Minor allele frequency- A:0.33MN NA 188
    rs31843371,2
    --24872904(-) CAGATA/TTCATT 1 -- ut310--------
    rs31843301,2
    --24872915(-) TTTATT/CGGTAA 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs1176545171,2
    C,F--24872922(+) TAAAAC/TGCATT 1 -- ut311Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for ARHGAP21 (24872538 - 25012597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARHGAP21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734095CNV Deletion23290073
    esv2666299CNV Deletion23128226
    nsv6099CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609870    OMIM disorders: --

    4 diseases for ARHGAP21:    About MalaCards
    influenza    glioblastoma    alzheimer's disease    squamous cell carcinoma


    ARHGAP21 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ARHGAP21
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP21 (1 document)

    Export disorders for ARHGAP21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP21 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ARHGAP21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PubMed id 12056806)1, 2, 3 Basseres D.S.... Saad S.T.O. (2002)
    2. Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. (PubMed id 22922005)1, 2 Bigarella C.L....Archangelo L.F. (2012)
    3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2 Menetrey J.... Houdusse A. (2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PubMed id 15793564)1, 2 Dubois T.... Chavrier P. (2005)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    7. Characterization of human ARHGAP10 gene in silico. (PubMed id 15375573)2, 9 Katoh M. and Katoh M. (2004)
    8. ARHGAP21 protein, a new partner of a-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transit ion. (PubMed id 23235160)1 Barcellos K.S....Saad S.T. (2013)
    9. Transport of influenza virus neuraminidase (NA) to hos t cell surface is regulated by ARHGAP21 and Cdc42 proteins. (PubMed id 22318733)1 Wang S....Chen J.L. (2012)
    10. I^-Arrestin 1 inhibits the GTPase-activating protein f unction of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. (PubMed id 21173159)1 Anthony D.F....Baillie G.S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57584 HGNC: 23725 AceView: ARHGAP21 Ensembl:ENSG00000107863 euGenes: HUgn57584
    ECgene: ARHGAP21 H-InvDB: ARHGAP21

    (According to HUGE)
    About This Section
    HUGE: KIAA1424

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP21 gene:
    Search GeneIP for patents involving ARHGAP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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