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Aliases for ARHGAP21 Gene

Aliases for ARHGAP21 Gene

  • Rho GTPase Activating Protein 21 2 3 5
  • Rho-Type GTPase-Activating Protein 21 3 4
  • Rho GTPase-Activating Protein 10 3 4
  • ARHGAP10 3 4
  • Rho-GTPase Activating Protein 10 3
  • Rho GTPase-Activating Protein 21 3
  • KIAA1424 4

External Ids for ARHGAP21 Gene

Previous GeneCards Identifiers for ARHGAP21 Gene

  • GC10M024876
  • GC10M024912
  • GC10M024873

Summaries for ARHGAP21 Gene

Entrez Gene Summary for ARHGAP21 Gene

  • ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP21 Gene

ARHGAP21 (Rho GTPase Activating Protein 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP23.

UniProtKB/Swiss-Prot for ARHGAP21 Gene

  • Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP21 Gene

Genomics for ARHGAP21 Gene

Regulatory Elements for ARHGAP21 Gene

Enhancers for ARHGAP21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G024929 1 ENCODE dbSUPER 20.6 -205.7 -205651 0.5 BACH1 BMI1 YBX1 EBF1 RELB IKZF2 MTA2 BHLHE40 NR2F1 TRIM22 ARHGAP21 PRTFDC1 RN7SKP241 GC10M024909 ENSG00000273107
GH10G024900 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -178.3 -178284 3.6 HDGF PKNOX1 ATF1 CREB3L1 ARNT WRNIP1 SIN3A FEZF1 BRCA1 TCF12 PRTFDC1 ARHGAP21 RN7SKP241 GC10M024909 ENSG00000228667
GH10G024920 1.6 Ensembl ENCODE dbSUPER 9.4 -198.2 -198200 2.8 PKNOX1 FOXA2 CREB3L1 ARNT ZNF766 FOS KLF13 JUNB REST TBX21 PRTFDC1 ARHGAP21 GC10M024909 RN7SKP241 ENSG00000273107
GH10G024762 1 Ensembl ENCODE 11.6 -39.2 -39208 1.4 HDAC1 FOXA2 ETV1 TEAD4 THRB TEAD3 NR2F6 MAFK ZNF652 SOX5 PRTFDC1 ARHGAP21 LOC105376456
GH10G024825 1 Ensembl ENCODE 10.1 -102.3 -102311 1.6 BCOR RFX1 JUN ZMYM3 CEBPB ZNF384 CEBPG EP300 FOSL1 JUND PRTFDC1 ARHGAP21 ENSG00000228667 LOC105376456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025683 1168 5800 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 FOS ZNF263 SP3 SP5

Genomic Location for ARHGAP21 Gene

Chromosome:
10
Start:
24,583,609 bp from pter
End:
24,723,668 bp from pter
Size:
140,060 bases
Orientation:
Minus strand

Genomic View for ARHGAP21 Gene

Genes around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP21 Gene

Proteins for ARHGAP21 Gene

  • Protein details for ARHGAP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5U3-RHG21_HUMAN
    Recommended name:
    Rho GTPase-activating protein 21
    Protein Accession:
    Q5T5U3
    Secondary Accessions:
    • Q0VF98
    • Q7Z3P7
    • Q8N3A2
    • Q8NI19
    • Q8TBV5
    • Q9P2C3

    Protein attributes for ARHGAP21 Gene

    Size:
    1957 amino acids
    Molecular mass:
    217331 Da
    Quaternary structure:
    • Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1.
    Miscellaneous:
    • Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.
    • Required for In1A-dependent entry of Listeria monocytogenes into cells.

    Three dimensional structures from OCA and Proteopedia for ARHGAP21 Gene

    Alternative splice isoforms for ARHGAP21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP21 Gene

Post-translational modifications for ARHGAP21 Gene

  • Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP21 Gene

Domains & Families for ARHGAP21 Gene

No data available for UniProtKB/Swiss-Prot for ARHGAP21 Gene

Function for ARHGAP21 Gene

Molecular function for ARHGAP21 Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon cell differentiation.

Gene Ontology (GO) - Molecular Function for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 17347647
genes like me logo Genes that share ontologies with ARHGAP21: view

Phenotypes for ARHGAP21 Gene

genes like me logo Genes that share phenotypes with ARHGAP21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP21 Gene

Localization for ARHGAP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP21 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA 20525016
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARHGAP21: view

Pathways & Interactions for ARHGAP21 Gene

genes like me logo Genes that share pathways with ARHGAP21: view

Pathways by source for ARHGAP21 Gene

3 Reactome pathways for ARHGAP21 Gene

Gene Ontology (GO) - Biological Process for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 20525016
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0051683 establishment of Golgi localization IDA 20525016
genes like me logo Genes that share ontologies with ARHGAP21: view

No data available for SIGNOR curated interactions for ARHGAP21 Gene

Drugs & Compounds for ARHGAP21 Gene

(2) Drugs for ARHGAP21 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0

(1) ApexBio Compounds for ARHGAP21 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARHGAP21: view

Drug Products

Transcripts for ARHGAP21 Gene

Unigene Clusters for ARHGAP21 Gene

Rho GTPase activating protein 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ARHGAP21 Gene

GeneLoc Exon Structure for
ARHGAP21
ECgene alternative splicing isoforms for
ARHGAP21

Expression for ARHGAP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP21 Gene

This gene is overexpressed in Plasma (29.4) and Fetal Brain (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP21 Gene



Protein tissue co-expression partners for ARHGAP21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP21 Gene:

ARHGAP21

SOURCE GeneReport for Unigene cluster for ARHGAP21 Gene:

Hs.524195

mRNA Expression by UniProt/SwissProt for ARHGAP21 Gene:

Q5T5U3-RHG21_HUMAN
Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for ARHGAP21 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ARHGAP21: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP21 Gene

Orthologs for ARHGAP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP21 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia ARHGAP21 34 35
  • 85.65 (n)
cow
(Bos Taurus)
Mammalia ARHGAP21 35 34
  • 84.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap21 34 16 35
  • 83.99 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap21 34
  • 83.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP21 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP21 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP21 34 35
  • 75.08 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP21 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap21 34
  • 67.44 (n)
Str.595 34
African clawed frog
(Xenopus laevis)
Amphibia rGAP 34
zebrafish
(Danio rerio)
Actinopterygii arhgap21b 34 35
  • 59.47 (n)
arhgap21a 35
  • 50 (a)
OneToMany
wufe14a09 34
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP19D 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pac-1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9299 35
  • 48 (a)
OneToMany
Species where no ortholog for ARHGAP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP21 Gene

ENSEMBL:
Gene Tree for ARHGAP21 (if available)
TreeFam:
Gene Tree for ARHGAP21 (if available)

Paralogs for ARHGAP21 Gene

Variants for ARHGAP21 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP21 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000002525 -- 24,724,156(+) AAAAC(A/C/G)AGGCA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000048373 -- 24,583,337(+) CTGAC(C/T)CCAAA downstream-variant-500B
rs1000052583 -- 24,631,369(+) CAAAA(A/G)AGAAA intron-variant
rs1000071913 -- 24,617,528(+) GCTTG(G/T)CCTTA intron-variant
rs1000112203 -- 24,718,472(+) TGGCT(C/T)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP21 Gene

Variant ID Type Subtype PubMed ID
esv2666299 CNV deletion 23128226
esv2734095 CNV deletion 23290073
esv3333243 CNV insertion 20981092
esv3622649 CNV loss 21293372
nsv1037958 CNV gain 25217958
nsv473270 CNV novel sequence insertion 20440878
nsv6099 CNV insertion 18451855
nsv947769 CNV duplication 23825009
nsv947770 CNV duplication 23825009
nsv982895 CNV duplication 23825009

Variation tolerance for ARHGAP21 Gene

Residual Variation Intolerance Score: 3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP21 Gene

Human Gene Mutation Database (HGMD)
ARHGAP21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Disorders for ARHGAP21 Gene

Relevant External Links for ARHGAP21

Genetic Association Database (GAD)
ARHGAP21
Human Genome Epidemiology (HuGE) Navigator
ARHGAP21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP21

No disorders were found for ARHGAP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP21 Gene

Publications for ARHGAP21 Gene

  1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PMID: 12056806) Basseres D.S. … Saad S.T.O. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 64
  2. Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. (PMID: 22922005) Bigarella C.L. … Archangelo L.F. (FEBS Lett. 2012) 3 4 64
  3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PMID: 17347647) Menetrey J. … Houdusse A. (EMBO J. 2007) 3 4 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PMID: 15793564) Dubois T. … Chavrier P. (Nat. Cell Biol. 2005) 3 4 64

Products for ARHGAP21 Gene

Sources for ARHGAP21 Gene

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