Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARHGAP21 Gene

protein-coding   GIFtS: 54
GCID: GC10M024873

Rho GTPase Activating Protein 21

  Search for ARHGAP21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Rho GTPase Activating Protein 211 2     KIAA14243 5
Rho GTPase-Activating Protein 102 3     Rho GTPase-Activating Protein 212
Rho-Type GTPase-Activating Protein 212 3     Rho-GTPase Activating Protein 102
ARHGAP102 3     

External Ids:    HGNC: 237251   Entrez Gene: 575842   Ensembl: ENSG000001078637   OMIM: 6098705   UniProtKB: Q5T5U33   

Export aliases for ARHGAP21 gene to outside databases

Previous GC identifers: GC10M024876 GC10M024912 GC10M024534


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARHGAP21 Gene:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the
ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al.,
2005 (PubMed 15793564)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARHGAP21 Gene:
ARHGAP21 (Rho GTPase activating protein 21) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP27.

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP21 gene promoter:
         LHX3b/Lhx3b   NF-1   AML1a   GATA-3   GATA-1   GATA-2   S8   LHX3a/Lhx3a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP21 promoter sequence
   Search Chromatin IP Primers for ARHGAP21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.3   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.31

ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP21 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M024873:  view genomic region     (about GC identifiers)

Start:
24,872,538 bp from pter      End:
25,012,597 bp from pter
Size:
140,060 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 21  
Size: 1957 amino acids; 217331 Da
Subunit: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1
Miscellaneous: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers
Miscellaneous: Required for In1A-dependent entry of Listeria monocytogenes into cells
3 PDB 3D structures from and Proteopedia for ARHGAP21:
2DHJ (3D)        2J59 (3D)        2YUY (3D)    
Secondary accessions: Q0VF98 Q7Z3P7 Q8N3A2 Q8NI19 Q8TBV5 Q9P2C3
Alternative splicing: 2 isoforms:  Q5T5U3-1   Q5T5U3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP21: NX_Q5T5U3

Explore proteomics data for ARHGAP21 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065875.3  
    ENSEMBL proteins: 
     ENSP00000379709   ENSP00000389940   ENSP00000402761   ENSP00000365592   ENSP00000405018  
     ENSP00000400566   ENSP00000365604  

    ARHGAP21 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARHGAP21
    GenScript Custom Purified and Recombinant Proteins Services for ARHGAP21
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGAP21

     
    Search eBioscience for Proteins for ARHGAP21 

    ARHGAP21 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARHGAP21
    Novus Biologicals ARHGAP21 Antibody
    Abcam antibodies for ARHGAP21
    Cloud-Clone Corp. Antibodies for ARHGAP21
    Search ThermoFisher Antibodies for ARHGAP21
    LSBio Antibodies in human, mouse, rat for ARHGAP21

    ARHGAP21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGAP21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGAP21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGAP21
    Cloud-Clone Corp. CLIAs for ARHGAP21
    Search eBioscience for ELISAs for ARHGAP21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR001478 PDZ
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q5T5U3

    ProtoNet protein and cluster: Q5T5U3

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001605 Spectrin pleckstrin homology domain signature


    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG21_HUMAN, Q5T5U3
    Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
    control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions
    Induction: Up-regulated upon cell differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI17347647
         
    Find genes that share ontologies with ARHGAP21           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGAP21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGAP21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGAP21

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARHGAP21:
    hsa-mir-361-3p (MIRT038266), hsa-mir-335-5p (MIRT017485), hsa-mir-21-5p (MIRT030816), hsa-mir-183-5p (MIRT047126)

    Block miRNA regulation of human, mouse, rat ARHGAP21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP21 (see all 35):
    hsa-miR-3074-3p hsa-miR-298 hsa-miR-149 hsa-miR-3163 hsa-miR-183 hsa-miR-548e hsa-miR-1 hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGAP21
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGAP21

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGAP21 (see all 8)
    OriGene ORF clones in mouse, rat for ARHGAP21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP21 (NM_020824)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGAP21
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGAP21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RHG21_HUMAN, Q5T5U3: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle
    membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on
    interaction with GTP-bound ARF1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    cytosol3
    nucleus3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005794Golgi apparatus IDA--
    GO:0005856cytoskeleton IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with ARHGAP21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP21
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ARHGAP21 (Q5T5U31, 2, 3 ENSP000003797094) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974844 I2D: score=2 
    EEF1DP296921, 3EBI-1642518,EBI-358607 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-3295618 I2D: score=1 STRING: ENSP00000309503
    ARF1P840773, ENSP000002721024I2D: score=2 STRING: ENSP00000272102
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization IMP--
    GO:0007165signal transduction IEA--
    GO:0051683establishment of Golgi localization IDA--
    GO:0051684maintenance of Golgi location IMP--
    GO:0072384organelle transport along microtubule IMP--

    Find genes that share ontologies with ARHGAP21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP21 (RHG21)

    1 HMDB Compound for ARHGAP21    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARHGAP21 gene: 
    NM_020824.3  

    Unigene Cluster for ARHGAP21:

    Rho GTPase activating protein 21
    Hs.524195  [show with all ESTs]
    Unigene Representative Sequence: NM_020824
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396432(uc010qdb.1 uc001isb.2) ENST00000486374 ENST00000477190
    ENST00000418033 ENST00000482792 ENST00000418325 ENST00000376410(uc010qdc.1)
    ENST00000446003(uc009xkl.1 uc001isc.1) ENST00000493154 ENST00000476067
    ENST00000483114 ENST00000476499(uc001isd.1) ENST00000416305 ENST00000472150
    ENST00000463892 ENST00000320481
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGAP21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP21 (see all 35):
    hsa-miR-3074-3p hsa-miR-298 hsa-miR-149 hsa-miR-3163 hsa-miR-183 hsa-miR-548e hsa-miR-1 hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGAP21
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP21
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGAP21 (see all 8)
    OriGene ORF clones in mouse, rat for ARHGAP21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP21 (NM_020824)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP21
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP21
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP21

    Additional mRNA sequence: 

    AB037845.2 AF480466.1 AK090642.1 AK295649.1 AK297278.1 AK307604.1 AL834495.1 BC022931.1 
    BC118915.2 

    18 DOTS entries:

    DT.444446  DT.99962095  DT.121291442  DT.91952775  DT.121343937  DT.91897476  DT.121343936  DT.92419733 
    DT.121291398  DT.121364000  DT.40273675  DT.100656762  DT.100710705  DT.95207218  DT.99938162  DT.121291470 
    DT.121306615  DT.453753 

    Selected AceView cDNA sequences (see all 242):

    NM_020824 AW001808 CA413503 AI796744 BM683250 BP363533 BQ027782 BE856005 
    BG152506 AB037845 BM980486 AA600946 BM719318 AI373662 BE858783 BQ948821 
    BQ574876 CB215984 BE550507 AA236188 AL701494 AA568361 AW593794 H71148 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:        -     -                 -                                   -     -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                -                                   -     -     -                                                                           
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:                    -                 -               
    SP2:                    -                 -               
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ARHGAP21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARHGAP21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP21 Expression
    About this image


    ARHGAP21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    ARHGAP21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524195

    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta

        Custom PCR Arrays for ARHGAP21
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP21
    QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP21
    QuantiFast Probe-based Assays in human, mouse, rat ARHGAP21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP21 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap211 , 5 Rho GTPase activating protein 211, 5 83.99(n)1
    87.28(a)1
      2 (14.60 cM)5
    714351  NM_001128084.21  NP_001121556.21 
     208479195 
    chicken
    (Gallus gallus)
    Aves ARHGAP211 Rho GTPase activating protein 21 75.08(n)
    74.87(a)
      420500  NM_001177357.1  NP_001170828.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP216
    Rho GTPase activating protein 21
    69(a)
    1 ↔ 1
    6(15289129-15419344)
    African clawed frog
    (Xenopus laevis)
    Amphibia rGAP2 rho-GTPase activating protein 76.85(n)    AF462392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe14a092 Transcribed sequence with weak similarity to protein more 76.03(n)    AL922797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP19D6
    RhoGAP19D
    18(a)
    1 → many
    X(20340982-20381721)
    worm
    (Caenorhabditis elegans)
    Secernentea pac-16
    Protein PAC-1, isoform c (pac-1) mRNA, complete cd...
    21(a)
    1 → many
    III(8493878-8518882) WBGene00015418


    ENSEMBL Gene Tree for ARHGAP21 (if available)
    TreeFam Gene Tree for ARHGAP21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARHGAP21 gene
    ARHGAP272  ARHGAP102  CHN22  ARHGAP232  ARHGAP92  CHN12  ARHGAP262  ARHGAP152  
    ARHGAP122  OPHN12  ARHGAP422  
    Selected SIMAP similar genes for ARHGAP21 using alignment to 8 protein entries:     RHG21_HUMAN (see all proteins) (see all similar genes):
    ARHGAP23    ARHGAP6    OPHN1    SYDE1    SRGAP1    ARHGAP19
    ARHGAP19-SLIT1    ARHGAP10    ARHGAP27    ARHGAP24    ARHGAP5    SRGAP2
    ARHGAP12    ARHGAP22    HMHA1    ARHGAP4    ARHGAP44    CHN1

    Find genes that share paralogs with ARHGAP21           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ARHGAP21
    PGOHUM00000248722 PGOHUM00000260133 PGOHUM00000260134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARHGAP21 (see all 2777)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833137141,2
    --24872041(+) TCAGCC/TTTAAC 1 -- int10--------
    rs118159131,2
    C,H--24872179(+) gttacT/Cgtaac 1 -- int11Minor allele frequency- C:0.25NA 4
    rs1484705781,2
    --24872217(+) AGAGAA/CGTTAA 1 -- int10--------
    rs118159631,2
    C,F,H--24872478(+) AATCAT/CGTAAG 1 -- int15Minor allele frequency- C:0.18NA WA CSA 215
    rs1452978441,2
    --24872645(+) TTCTCA/GATAAA 1 -- ut310--------
    rs32109161,2
    --24872860(-) ACTTCC/AATTCT 1 -- ut313Minor allele frequency- A:0.33MN NA 188
    rs31843371,2
    --24872904(-) CAGATA/TTCATT 1 -- ut310--------
    rs31843301,2
    --24872915(-) TTTATT/CGGTAA 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs1176545171,2
    C,F--24872922(+) TAAAAC/TGCATT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs31843241,2
    --24872923(-) GAATGC/TGTTTT 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184

    HapMap Linkage Disequilibrium report for ARHGAP21 (24872538 - 25012597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARHGAP21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734095CNV Deletion23290073
    esv2666299CNV Deletion23128226
    nsv6099CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP21
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609870    OMIM disorders: --


    Find genes that share disorders with ARHGAP21           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP21
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP21 (1 document)

    Export disorders for ARHGAP21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARHGAP21 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ARHGAP21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PubMed id 12056806)1, 2, 3 Basseres D.S.... Saad S.T.O. (Biochem. Biophys. Res. Commun. 2002)
    2. Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. (PubMed id 22922005)1, 2 Bigarella C.L....Archangelo L.F. (FEBS Lett. 2012)
    3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2 Menetrey J.... Houdusse A. (EMBO J. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PubMed id 15793564)1, 2 Dubois T.... Chavrier P. (Nat. Cell Biol. 2005)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Characterization of human ARHGAP10 gene in silico. (PubMed id 15375573)2, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    8. ARHGAP21 protein, a new partner of I+-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition. (PubMed id 23235160)1 Barcellos K.S....Saad S.T. (J. Biol. Chem. 2013)
    9. Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. (PubMed id 22318733)1 Wang S....Chen J.L. (J. Biol. Chem. 2012)
    10. I^-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. (PubMed id 21173159)1 Anthony D.F....Baillie G.S. (Mol. Cell. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57584 HGNC: 23725 AceView: ARHGAP21 Ensembl:ENSG00000107863 euGenes: HUgn57584
    ECgene: ARHGAP21 H-InvDB: ARHGAP21

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1424

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARHGAP21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARHGAP21 gene:
    Search GeneIP for patents involving ARHGAP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARHGAP21  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARHGAP21  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP21   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARHGAP21   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGAP21   OriGene Custom Protein Services for ARHGAP21  

     
     
     Block miRNA regulation of human, mouse, rat ARHGAP21 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARHGAP21
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP21 Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP21
     QuantiFast Probe-based Assays in human, mouse, rat ARHGAP21 QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP21
     Custom PCR Arrays for ARHGAP21 Search Chromatin IP Primers for ARHGAP21
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP21  Search GeneGlobe Interaction Network for ARHGAP21
     Regulatory tfbs in ARHGAP21 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARHGAP21 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP21
     GenScript Custom Assay Services for ARHGAP21 GenScript Custom overexpressing Cell Line Services for ARHGAP21
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARHGAP21 (RHG21)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARHGAP21 antibodies
     Antibodies for ARHGAP21
     See all of Abcam's Antibodies, Kits and Proteins for ARHGAP21
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARHGAP21
     Antibodies for ARHGAP21
     ELISAs for ARHGAP21
     CLIAs for ARHGAP21



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGAP21
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGAP21
     SwitchGear Promoter luciferase reporter plasmids for ARHGAP21
     Search ThermoFisher Antibodies for ARHGAP21
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP21
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGAP21
     LSBio Antibodies in human, mouse, rat for ARHGAP21
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARHGAP21
      Search eBioscience for proteins for ARHGAP21
      Search eBioscience for elisas for ARHGAP21
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGAP21 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4