Aliases for ARHGAP21 Gene
External Ids for ARHGAP21 Gene
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP21 Gene
ARHGAP21 (Rho GTPase Activating Protein 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is CHN1.
UniProtKB/Swiss-Prot for ARHGAP21 Gene
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.