ARHGAP21 Gene
protein-coding GIFtS: 49
GCID: GC10M024873
|
|
Rho GTPase activating protein 21
| |
Aliases
for ARHGAP21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 211 2 | | Rho-Type GTPase-Activating Protein 212 3 | | ARHGAP101 2 3 | | Rho GTPase-Activating Protein 212 | | KIAA14241 3 5 | | Rho-GTPase Activating Protein 102 | | Rho GTPase-Activating Protein 102 3 | | |
Export aliases for ARHGAP21 gene to outside databasesPrevious GC identifers: GC10M024876 GC10M024912 GC10M024534 |
Summaries
for ARHGAP21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGAP21:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 (PubMed15793564)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which maycontrol Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions
|
Genomic Views
for ARHGAP21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGAP21 gene promoter:
LHX3b/Lhx3b NF-1 AML1a GATA-3 GATA-1 GATA-2 S8 LHX3a/Lhx3a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.1|10p12.3 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.31ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M024873: view genomic region
(about GC identifiers)
Start:
|
24,872,538 bp from pter |
End:
|
25,012,597 bp from pter |
Size:
|
140,060 bases |
Orientation:
|
minus strand |
|
Proteins
for ARHGAP21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 21 Size: 1957 amino acids; 217331 Da
Subunit: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesiclemembrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent oninteraction with GTP-bound ARF1
Miscellaneous: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers
Miscellaneous: Required for In1A-dependent entry of Listeria monocytogenes into cells
3 PDB 3D structures from  and Proteopedia  for ARHGAP21:2DHJ (3D)
2J59 (3D)
2YUY (3D)
Secondary accessions: Q0VF98 Q7Z3P7 Q8N3A2 Q8NI19 Q8TBV5 Q9P2C3Alternative splicing: 2 isoforms: Q5T5U3-1 Q5T5U3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARHGAP21: NX_Q5T5U3
Post-translational modifications:
Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T5U3
ARHGAP21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065875.3
ENSEMBL proteins: ENSP00000379709 ENSP00000389940 ENSP00000402761 ENSP00000365592 ENSP00000405018 ENSP00000400566 ENSP00000365604
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
ARHGAP21 for ontologies About GeneDecksing
ARHGAP21 Antibody Products:
Assay Products for ARHGAP21: |
Protein
Domains /
Families
for ARHGAP21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP21 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T5U3ProtoNet protein and cluster: Q5T5U3 2 Blocks protein families: IPB000198 RhoGAP domain IPB001605 Spectrin pleckstrin homology domain signature
UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3Similarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 Rho-GAP domain |
Function
for ARHGAP21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which maycontrol Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctionsInduction: Up-regulated upon cell differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGAP21 (NM_020824) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ARHGAP21 for ontologies About GeneDecksing
|
Pathways & Interactions
for ARHGAP21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/42 Interacting proteins for ARHGAP21 (Q5T5U31, 2, 3 ENSP000003797094) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007030 | Golgi organization |
IMP | -- | | GO:0007165 | signal transduction |
IEA | -- | | GO:0051683 | establishment of Golgi localization |
IDA | -- | | GO:0051684 | maintenance of Golgi location |
IMP | -- | | GO:0072384 | organelle transport along microtubule |
IMP | -- |
ARHGAP21 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGAP21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGAP21
1 HMDB Compound for ARHGAP21 About this table
Search CenterWatch for drugs/clinical trials and news about ARHGAP21 / RHG21
|
Transcripts
for ARHGAP21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGAP21 gene: NM_020824.3 Unigene Cluster for ARHGAP21: Rho GTPase activating protein 21 Hs.524195 [show with all ESTs]Unigene Representative Sequence: NM_02082417 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396432(uc010qdb.1 uc001isb.2) ENST00000486374 ENST00000477190
ENST00000418033 ENST00000477137 ENST00000482792 ENST00000418325 ENST00000376410(uc010qdc.1)
ENST00000446003(uc009xkl.1 uc001isc.1) ENST00000493154 ENST00000476067
ENST00000483114 ENST00000476499(uc001isd.1) ENST00000416305 ENST00000472150
ENST00000463892 ENST00000320481
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGAP21 (NM_020824) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21 |
Additional cDNA sequence: AB037845.2 AF480466.1 AK090642.1 AK295649.1 AK297278.1 AK307604.1 AL834495.1 BC022931.1 BC118915.2 18 DOTS entries: DT.444446 DT.99962095 DT.121291442 DT.91952775 DT.121343937 DT.91897476 DT.121343936 DT.92419733 DT.121291398 DT.121364000 DT.40273675 DT.100656762 DT.100710705 DT.95207218 DT.99938162 DT.121291470 DT.121306615 DT.453753 24/242 AceView cDNA sequences (see all 242): BM719318 AA587458 AA600946 AW338526 AI081012 AI160830 CA430962 CB215984 CF144649 BE550507 AB037845 CA413503 AA236188 NM_020824 BQ027782 AW088269 AA568361 BQ574876 BM562264 BP349812 AW593794 AI796744 H71148 AW001808
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
|
| SP1: | | | - | | - | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGAP21
|
Expression
for ARHGAP21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ARHGAP21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP21
SOURCE GeneReport for Unigene cluster: Hs.524195
UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta
SABiosciences Custom PCR Arrays for ARHGAP21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21 |
Orthologs
for ARHGAP21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP21 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGAP211 |
Rho GTPase activating protein 21 |
75.06(n)
74.87(a) |
|
420500 NM_001177357.1 NP_001170828.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGAP216 |
-- |
79(a) |
1 ↔ 1 |
6(15395091-15417946) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rGAP2 |
rho-GTPase activating protein |
76.85(n) |
|
AF462392.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufe14a092 |
Transcribed sequence with weak similarity to protein more |
76.03(n) |
|
AL922797.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGAP19D6 |
RhoGAP19D |
16(a) |
1 → many |
X(20340982-20381721) |
worm
(Caenorhabditis elegans) |
Secernentea |
rga-56pac-16 |
GTPase-activating protein pac-1 |
6(a)19(a) |
possible ortholog1 ↔ many |
IV(13827861-13844953) III(8493801-8518803) |
ENSEMBL Gene Tree for ARHGAP21 (if available)
TreeFam Gene Tree for ARHGAP21 (if available) |
Paralogs
for ARHGAP21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGAP21 gene
- HMHA12 ARHGAP272 CHN22 ARHGAP102 ARHGAP232 ARHGAP92 ARHGAP292 CHN12
- ARHGAP262 ARHGAP152 ARHGAP122 OPHN12 GMIP2 ARHGAP422
18/36 SIMAP similar genes for ARHGAP21 using alignment to 8 protein entries: RHG21_HUMAN (see all proteins)
(see all similar genes):ARHGAP23 ARHGAP6 OPHN1 SRGAP1 ARHGAP19 ARHGAP12
ARHGAP10 ARHGAP27 ARHGAP24 ARHGAP5 SRGAP2 HMHA1
ARHGAP4 ARHGAP22 ARHGAP44 CHN1 ARHGAP26 CHN2-3
ARHGAP21 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ARHGAP21
PGOHUM00000248722 PGOHUM00000260133 PGOHUM00000260134
|
Genomic Variants
for ARHGAP21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP21 (24872538 - 25012597 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGAP21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP21 |
|
Disorders
/ Diseases
for ARHGAP21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP21 for disorders About GeneDecksing
OMIM gene information: 609870
OMIM disorders: --
4  diseases for ARHGAP21: About MalaCardssquamous cell carcinoma alzheimer's disease glioblastoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: ARHGAP21 (1 document)
Export disorders for ARHGAP21 gene to outside databases
|
Publications
for ARHGAP21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP21 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with ARHGAP21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PubMed id 12056806)1, 2, 3 Basseres D.S.... Saad S.T.O. (2002)
- Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. (PubMed id 22922005)1, 2 Bigarella C.L....Archangelo L.F. (2012)
- Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2 Menetrey J.... Houdusse A. (2007)
- Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PubMed id 15793564)1, 2 Dubois T.... Chavrier P. (2005)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Characterization of human ARHGAP10 gene in silico. (PubMed id 15375573)2, 9 Katoh M. and Katoh M. (2004)
- Transport of influenza virus neuraminidase (NA) to hos t cell surface is regulated by ARHGAP21 and Cdc42 proteins. (PubMed id 22318733)1 Wang S....Chen J.L. (2012)
- I^-Arrestin 1 inhibits the GTPase-activating protein f unction of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. (PubMed id 21173159)1 Anthony D.F....Baillie G.S. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for ARHGAP21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGAP21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP21 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGAP21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGAP21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGAP21 gene:
Search GeneIP for patents involving ARHGAP21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGAP21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP21 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ARHGAP21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGAP21 | | OriGene Custom Protein Services for ARHGAP21 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP21 |
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 | | | ARHGAP21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP21 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARHGAP21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP21 |
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