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Aliases for ARHGAP20 Gene

Aliases for ARHGAP20 Gene

  • Rho GTPase Activating Protein 20 2 3 5
  • Rho-Type GTPase-Activating Protein 20 3 4
  • Rho GTPase Activating Protein 20 Variant 2 3
  • RA And RhoGAP Domain Containing Protein 3
  • Rho GTPase-Activating Protein 20 3
  • RARHOGAP 3
  • KIAA1391 4

External Ids for ARHGAP20 Gene

Previous GeneCards Identifiers for ARHGAP20 Gene

  • GC11M109985
  • GC11M109952
  • GC11M110447
  • GC11M106372

Summaries for ARHGAP20 Gene

Entrez Gene Summary for ARHGAP20 Gene

  • The protein encoded by this gene is an activator of RHO-type GTPases, transducing a signal from RAP1 to RHO and impacting neurite outgrowth. [provided by RefSeq, Sep 2016]

GeneCards Summary for ARHGAP20 Gene

ARHGAP20 (Rho GTPase Activating Protein 20) is a Protein Coding gene. Diseases associated with ARHGAP20 include Chronic Lymphocytic Leukemia. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TAGAP.

UniProtKB/Swiss-Prot for ARHGAP20 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP20 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP20 Gene

Genomics for ARHGAP20 Gene

Regulatory Elements for ARHGAP20 Gene

Enhancers for ARHGAP20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H110710 1.5 FANTOM5 Ensembl ENCODE 12.9 +1.1 1050 3 INSM2 KLF17 FEZF1 ZNF2 RAD21 RARA GLIS2 ZNF366 SCRT2 EGR2 ARHGAP20 GC11P110684
GH11H110762 1 Ensembl ENCODE 5.1 -50.2 -50206 1 FOXA2 MAX FEZF1 EBF1 RAD21 YY1 ZFHX2 HNF4G RFX1 NFIA ARHGAP20 HNRNPA1P60
GH11H110759 0.7 ENCODE 5.3 -46.8 -46830 0 FEZF1 ZNF843 OSR2 PRDM6 GLIS2 ZBTB48 ZNF341 GLIS1 ZSCAN5C PRDM10 ARHGAP20 HNRNPA1P60
GH11H110777 0.8 Ensembl ENCODE 0.2 -65.2 -65198 1 GATA3 IKZF1 MNT FOS IKZF2 SPI1 SETDB1 HNRNPA1P60 ARHGAP20
GH11H110715 0.2 ENCODE 0.7 -2.5 -2524 0 ARHGAP20 HNRNPA1P60
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP20 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044737 889 1001 CTCF MXI1 ZNF777 ZIC2 ZNF2 ZFHX2 GLIS2 POLR2A ZBTB48 ZNF600

Genomic Location for ARHGAP20 Gene

Chromosome:
11
Start:
110,576,855 bp from pter
End:
110,713,189 bp from pter
Size:
136,335 bases
Orientation:
Minus strand

Genomic View for ARHGAP20 Gene

Genes around ARHGAP20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP20 Gene

Proteins for ARHGAP20 Gene

  • Protein details for ARHGAP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2F6-RHG20_HUMAN
    Recommended name:
    Rho GTPase-activating protein 20
    Protein Accession:
    Q9P2F6
    Secondary Accessions:
    • A8K8C5
    • B0YIW7
    • B0YIW8
    • Q6RJU1
    • Q6RJU2
    • Q6RJU3
    • Q6RJU5
    • Q8IXS1

    Protein attributes for ARHGAP20 Gene

    Size:
    1191 amino acids
    Molecular mass:
    132608 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39340.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH39340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92629.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF84979.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF84979.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP20 Gene

    Alternative splice isoforms for ARHGAP20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP20 Gene

Post-translational modifications for ARHGAP20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP20 Gene

Domains & Families for ARHGAP20 Gene

Gene Families for ARHGAP20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARHGAP20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP20: view

No data available for UniProtKB/Swiss-Prot for ARHGAP20 Gene

Function for ARHGAP20 Gene

Molecular function for ARHGAP20 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP20 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP20: view
genes like me logo Genes that share phenotypes with ARHGAP20: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP20 Gene

miRTarBase miRNAs that target ARHGAP20

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGAP20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP20 Gene

Localization for ARHGAP20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP20 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP20: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP20 Gene

Pathways & Interactions for ARHGAP20 Gene

genes like me logo Genes that share pathways with ARHGAP20: view

Pathways by source for ARHGAP20 Gene

1 GeneTex pathway for ARHGAP20 Gene
3 Reactome pathways for ARHGAP20 Gene

Gene Ontology (GO) - Biological Process for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP20: view

No data available for SIGNOR curated interactions for ARHGAP20 Gene

Drugs & Compounds for ARHGAP20 Gene

No Compound Related Data Available

Transcripts for ARHGAP20 Gene

Unigene Clusters for ARHGAP20 Gene

Rho GTPase activating protein 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGAP20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for ARHGAP20 Gene

GeneLoc Exon Structure for
ARHGAP20
ECgene alternative splicing isoforms for
ARHGAP20

Expression for ARHGAP20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP20 Gene

This gene is overexpressed in Urine (43.2), Brain (9.5), and Plasma (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP20 Gene



Protein tissue co-expression partners for ARHGAP20 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP20 Gene:

ARHGAP20

SOURCE GeneReport for Unigene cluster for ARHGAP20 Gene:

Hs.6136

mRNA Expression by UniProt/SwissProt for ARHGAP20 Gene:

Q9P2F6-RHG20_HUMAN
Tissue specificity: Expressed predominantly in the brain. Lower expression is found in lymph nodes.

Evidence on tissue expression from TISSUES for ARHGAP20 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ARHGAP20: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP20 Gene

Orthologs for ARHGAP20 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP20 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia ARHGAP20 33 34
  • 88.64 (n)
cow
(Bos Taurus)
Mammalia ARHGAP20 33
  • 88.21 (n)
-- 34
  • 85 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Arhgap20 33 16 34
  • 82.2 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap20 33
  • 81.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARHGAP20 33
  • 65.83 (n)
-- 34
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4409 33
zebrafish
(Danio rerio)
Actinopterygii arhgap20b 34
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 34
  • 8 (a)
OneToMany
Species where no ortholog for ARHGAP20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP20 Gene

ENSEMBL:
Gene Tree for ARHGAP20 (if available)
TreeFam:
Gene Tree for ARHGAP20 (if available)

Paralogs for ARHGAP20 Gene

Paralogs for ARHGAP20 Gene

(1) SIMAP similar genes for ARHGAP20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP20: view

Variants for ARHGAP20 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP20 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193920992 Uncertain significance 110,624,201(-) CTTTG(C/T)TTTGG reference, missense
rs1000037670 -- 110,698,995(+) TTGAG(A/G)TGTGA intron-variant
rs1000088545 -- 110,655,295(+) CTCTA(A/G)GTATA intron-variant
rs1000104561 -- 110,700,407(+) CTTGA(C/G)TATTA intron-variant
rs1000114020 -- 110,678,055(+) ACATG(C/G)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP20 Gene

Variant ID Type Subtype PubMed ID
dgv2183n54 CNV loss 21841781
dgv242n67 CNV loss 20364138
dgv722n106 CNV tandem duplication 24896259
esv1311954 CNV deletion 17803354
esv21558 CNV loss 19812545
esv2745065 CNV deletion 23290073
esv2745066 CNV deletion 23290073
esv2745067 CNV deletion 23290073
esv3331551 CNV duplication 20981092
nsv468868 CNV loss 19166990
nsv556436 CNV loss 21841781
nsv826088 CNV gain 20364138
nsv832266 CNV gain 17160897

Variation tolerance for ARHGAP20 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP20 Gene

Disorders for ARHGAP20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP20 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RHG20_HUMAN
  • Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL) (PubMed:15543602). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes (PubMed:15543602). {ECO:0000269 PubMed:15543602}.

Relevant External Links for ARHGAP20

Genetic Association Database (GAD)
ARHGAP20
Human Genome Epidemiology (HuGE) Navigator
ARHGAP20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP20
genes like me logo Genes that share disorders with ARHGAP20: view

No data available for Genatlas for ARHGAP20 Gene

Publications for ARHGAP20 Gene

  1. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. (PMID: 14532992) Katoh M … Katoh M (International journal of oncology 2003) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes. (PMID: 15543602) Kalla C … Lichter P (Genes, chromosomes & cancer 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60

Products for ARHGAP20 Gene

Sources for ARHGAP20 Gene

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