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Aliases for ARHGAP20 Gene

Aliases for ARHGAP20 Gene

  • Rho GTPase Activating Protein 20 2 3
  • Rho-Type GTPase-Activating Protein 20 3 4
  • Rho GTPase Activating Protein 20 Variant 2 3
  • RA And RhoGAP Domain Containing Protein 3
  • Rho GTPase-Activating Protein 20 3
  • RARHOGAP 3
  • KIAA1391 4

External Ids for ARHGAP20 Gene

Summaries for ARHGAP20 Gene

GeneCards Summary for ARHGAP20 Gene

ARHGAP20 (Rho GTPase Activating Protein 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is TAGAP.

UniProtKB/Swiss-Prot for ARHGAP20 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP20 Gene

Genomics for ARHGAP20 Gene

Genomic Location for ARHGAP20 Gene

Start:
110,577,035 bp from pter
End:
110,713,189 bp from pter
Size:
136,155 bases
Orientation:
Minus strand

Genomic View for ARHGAP20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP20 Gene

Regulatory Elements for ARHGAP20 Gene

Proteins for ARHGAP20 Gene

  • Protein details for ARHGAP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2F6-RHG20_HUMAN
    Recommended name:
    Rho GTPase-activating protein 20
    Protein Accession:
    Q9P2F6
    Secondary Accessions:
    • A8K8C5
    • B0YIW7
    • B0YIW8
    • Q6RJU1
    • Q6RJU2
    • Q6RJU3
    • Q6RJU5
    • Q8IXS1

    Protein attributes for ARHGAP20 Gene

    Size:
    1191 amino acids
    Molecular mass:
    132608 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39340.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH39340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92629.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF84979.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF84979.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP20 Gene

    Alternative splice isoforms for ARHGAP20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP20 Gene

Proteomics data for ARHGAP20 Gene at MOPED

Post-translational modifications for ARHGAP20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP20 Gene

No data available for DME Specific Peptides for ARHGAP20 Gene

Domains for ARHGAP20 Gene

Gene Families for ARHGAP20 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

UniProtKB/Swiss-Prot:

RHG20_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9P2F6
  • Contains 1 Ras-associating domain.:
    • Q9P2F6
  • Contains 1 Rho-GAP domain.:
    • Q9P2F6
genes like me logo Genes that share domains with ARHGAP20: view

Function for ARHGAP20 Gene

Molecular function for ARHGAP20 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP20: view
genes like me logo Genes that share phenotypes with ARHGAP20: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP20 Gene

Localization for ARHGAP20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP20 Gene COMPARTMENTS Subcellular localization image for ARHGAP20 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP20: view

Pathways for ARHGAP20 Gene

genes like me logo Genes that share pathways with ARHGAP20: view

Pathways by source for ARHGAP20 Gene

3 Reactome pathways for ARHGAP20 Gene

Gene Ontology (GO) - Biological Process for ARHGAP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP20: view

Transcripts for ARHGAP20 Gene

Unigene Clusters for ARHGAP20 Gene

Rho GTPase activating protein 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for ARHGAP20 Gene

GeneLoc Exon Structure for
ARHGAP20
ECgene alternative splicing isoforms for
ARHGAP20

Expression for ARHGAP20 Gene

mRNA expression in normal human tissues for ARHGAP20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGAP20 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP20 Gene Hs.6136

mRNA Expression by UniProt/SwissProt for ARHGAP20 Gene

Q9P2F6-RHG20_HUMAN
Tissue specificity: Expressed predominantly in the brain. Lower expression is found in lymph nodes.
genes like me logo Genes that share expressions with ARHGAP20: view

Orthologs for ARHGAP20 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP20 36
  • 99.64 (n)
  • 99.24 (a)
ARHGAP20 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 85 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
ARHGAP20 36
  • 88.21 (n)
  • 85.15 (a)
dog
(Canis familiaris)
Mammalia ARHGAP20 36
  • 88.64 (n)
  • 86.68 (a)
ARHGAP20 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap20 36
  • 82.2 (n)
  • 80.03 (a)
Arhgap20 16
Arhgap20 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Arhgap20 36
  • 81.06 (n)
  • 79.63 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 51 (a)
ManyToMany
ARHGAP20 36
  • 65.83 (n)
  • 59.87 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4409 36
zebrafish
(Danio rerio)
Actinopterygii arhgap20b 37
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 37
  • 8 (a)
OneToMany
Species with no ortholog for ARHGAP20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP20 Gene

ENSEMBL:
Gene Tree for ARHGAP20 (if available)
TreeFam:
Gene Tree for ARHGAP20 (if available)

Paralogs for ARHGAP20 Gene

Paralogs for ARHGAP20 Gene

Selected SIMAP similar genes for ARHGAP20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP20: view

Variants for ARHGAP20 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP20 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2023 -- 110,578,481(-) AATTA(A/C)ACAAA utr-variant-3-prime
rs186601 -- 110,638,814(+) atgga(C/T)gcagg intron-variant
rs189004 -- 110,608,147(-) GTAAT(A/T)CTTTC intron-variant
rs189790 -- 110,621,403(+) ttttt(C/G)atata intron-variant
rs227449 -- 110,639,484(+) gtaca(C/T)tgaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP20 Gene

Variant ID Type Subtype PubMed ID
nsv898392 CNV Loss 21882294
nsv468868 CNV Loss 19166990
nsv898393 CNV Loss 21882294
esv21558 CNV Loss 19812545
esv2745065 CNV Deletion 23290073
esv1311954 CNV Deletion 17803354
dgv242n67 CNV Loss 20364138
esv2745066 CNV Deletion 23290073
esv2745067 CNV Deletion 23290073
nsv832266 CNV Gain 17160897
nsv826088 CNV Gain 20364138

Relevant External Links for ARHGAP20 Gene

HapMap Linkage Disequilibrium report
ARHGAP20

Disorders for ARHGAP20 Gene

UniProtKB/Swiss-Prot

RHG20_HUMAN
  • Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.

Relevant External Links for ARHGAP20

Genetic Association Database (GAD)
ARHGAP20
Human Genome Epidemiology (HuGE) Navigator
ARHGAP20
genes like me logo Genes that share disorders with ARHGAP20: view

Publications for ARHGAP20 Gene

  1. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. (PMID: 14532992) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes. (PMID: 15543602) Kalla C. … Lichter P. (Genes Chromosomes Cancer 2005) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ARHGAP20 Gene

Sources for ARHGAP20 Gene

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