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Aliases for ARHGAP19-SLIT1 Gene

Subcategory (RNA class) for ARHGAP19-SLIT1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for ARHGAP19-SLIT1 Gene

  • ARHGAP19-SLIT1 Readthrough (NMD Candidate) 2 3 5

External Ids for ARHGAP19-SLIT1 Gene

Previous GeneCards Identifiers for ARHGAP19-SLIT1 Gene

  • GC10U901525
  • GC10M098757

Summaries for ARHGAP19-SLIT1 Gene

Entrez Gene Summary for ARHGAP19-SLIT1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring Rho GTPase activating protein 19 (ARHGAP19) and slit homolog 1 (SLIT1) genes on chromosome 10. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for ARHGAP19-SLIT1 Gene

ARHGAP19-SLIT1 (ARHGAP19-SLIT1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is ARHGAP11A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP19-SLIT1 Gene

Genomics for ARHGAP19-SLIT1 Gene

Regulatory Elements for ARHGAP19-SLIT1 Gene

Promoters for ARHGAP19-SLIT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP19-SLIT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP19-SLIT1 Gene

Chromosome:
10
Start:
97,153,042 bp from pter
End:
97,292,673 bp from pter
Size:
139,632 bases
Orientation:
Minus strand

Genomic View for ARHGAP19-SLIT1 Gene

Genes around ARHGAP19-SLIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP19-SLIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP19-SLIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP19-SLIT1 Gene

Proteins for ARHGAP19-SLIT1 Gene

Protein Expression for ARHGAP19-SLIT1 Gene

Post-translational modifications for ARHGAP19-SLIT1 Gene

No Post-translational modifications

Other Protein References for ARHGAP19-SLIT1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ARHGAP19-SLIT1 Gene

Domains & Families for ARHGAP19-SLIT1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARHGAP19-SLIT1 Gene

Function for ARHGAP19-SLIT1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP19-SLIT1 Gene

Localization for ARHGAP19-SLIT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ARHGAP19-SLIT1 Gene

Pathways & Interactions for ARHGAP19-SLIT1 Gene

SuperPathways for ARHGAP19-SLIT1 Gene

No Data Available

Interacting Proteins for ARHGAP19-SLIT1 Gene

Gene Ontology (GO) - Biological Process for ARHGAP19-SLIT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARHGAP19-SLIT1 Gene

Drugs & Compounds for ARHGAP19-SLIT1 Gene

No Compound Related Data Available

Transcripts for ARHGAP19-SLIT1 Gene

mRNA/cDNA for ARHGAP19-SLIT1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP19-SLIT1 Gene

No ASD Table

Relevant External Links for ARHGAP19-SLIT1 Gene

GeneLoc Exon Structure for
ARHGAP19-SLIT1
ECgene alternative splicing isoforms for
ARHGAP19-SLIT1

Expression for ARHGAP19-SLIT1 Gene

mRNA expression in normal human tissues for ARHGAP19-SLIT1 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP19-SLIT1 Gene

This gene is overexpressed in Pituitary (x13.1), Brain - Hippocampus (x5.7), and Brain - Amygdala (x4.5).

Protein differential expression in normal tissues from HIPED for ARHGAP19-SLIT1 Gene

This gene is overexpressed in Testis (61.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB for ARHGAP19-SLIT1 Gene



genes like me logo Genes that share expression patterns with ARHGAP19-SLIT1: view

Protein tissue co-expression partners for ARHGAP19-SLIT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP19-SLIT1 Gene

Orthologs for ARHGAP19-SLIT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP19-SLIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Arhgap19 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP19 36
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii arhgap19 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP54D 36
  • 6 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 36
  • 5 (a)
ManyToMany
RGA2 36
  • 5 (a)
ManyToMany
Species with no ortholog for ARHGAP19-SLIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP19-SLIT1 Gene

ENSEMBL:
Gene Tree for ARHGAP19-SLIT1 (if available)
TreeFam:
Gene Tree for ARHGAP19-SLIT1 (if available)

Paralogs for ARHGAP19-SLIT1 Gene

(3) SIMAP similar genes for ARHGAP19-SLIT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP19-SLIT1: view

Variants for ARHGAP19-SLIT1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP19-SLIT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs701802 -- 97,188,481(+) CAGCC(A/G)GGCCA intron-variant
rs701803 -- 97,188,914(+) TACTA(C/T)ATGTG intron-variant
rs701804 -- 97,189,154(+) GGCAA(C/G)AAAAC intron-variant
rs902466 -- 97,207,602(-) TGGGA(C/T)GCCCA intron-variant
rs1147597 -- 97,210,035(-) cccgg(C/G)taatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP19-SLIT1 Gene

Variant ID Type Subtype PubMed ID
essv12626 CNV CNV 17122850
nsv7506 CNV Loss 18451855
esv2739829 CNV Deletion 23290073
nsv433513 CNV Loss 18776910
esv2739840 CNV Deletion 23290073
esv2739851 CNV Deletion 23290073
nsv831952 CNV Loss 17160897
nsv895914 CNV Gain 21882294
nsv7507 CNV Loss 18451855
esv1003170 CNV Deletion 20482838
esv2429720 CNV Deletion 19546169
esv2304672 CNV Deletion 18987734
nsv512179 CNV Loss 21212237
esv5077 CNV Deletion 18987735
esv2739862 CNV Deletion 23290073
esv6307 CNV Loss 19470904
esv1001501 CNV Deletion 20482838
esv1315028 CNV Deletion 17803354

Variation tolerance for ARHGAP19-SLIT1 Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP19-SLIT1 Gene

HapMap Linkage Disequilibrium report
ARHGAP19-SLIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP19-SLIT1 Gene

Disorders for ARHGAP19-SLIT1 Gene

Relevant External Links for ARHGAP19-SLIT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP19-SLIT1

No disorders were found for ARHGAP19-SLIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP19-SLIT1 Gene

Publications for ARHGAP19-SLIT1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 67

Products for ARHGAP19-SLIT1 Gene

Sources for ARHGAP19-SLIT1 Gene

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