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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP19-SLIT1 Gene

protein-coding   GIFtS: 25
GCID: GC10M098757

ARHGAP19-SLIT1 Readthrough (NMD Candidate)

  Search for ARHGAP19-SLIT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ARHGAP19-SLIT1 Readthrough (NMD Candidate)1 2
Rho-Type GTPase-Activating Protein 193

External Ids:    HGNC: 483481   Entrez Gene: 1005331842   Ensembl: ENSG000002698917   UniProtKB: Q14CB83   

Export aliases for ARHGAP19-SLIT1 gene to outside databases

Previous GC identifer: GC10U901525


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP19-SLIT1 Gene:
This locus represents naturally occurring read-through transcription between the neighboring Rho GTPase activating
protein 19 (ARHGAP19) and slit homolog 1 (SLIT1) genes on chromosome 10. The read-through transcript is a
candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. (provided by
RefSeq, Feb 2011)

GeneCards Summary for ARHGAP19-SLIT1 Gene: 
ARHGAP19-SLIT1 (ARHGAP19-SLIT1 readthrough (NMD candidate)) is a protein-coding gene. An important paralog of this gene is ARHGAP19.

UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGAP19-SLIT1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARHGAP19-SLIT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP19-SLIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.1

ARHGAP19-SLIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP19-SLIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098757:  view genomic region     (about GC identifiers)

Start:
98,757,795 bp from pter      End:
99,052,430 bp from pter
Size:
294,636 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 19  
Size: 494 amino acids; 55756 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB84948.1; Type=Erroneous initiation; Sequence=BAC04165.1; Type=Frameshift;
Positions=280;
Secondary accessions: A1XCP1 B4DZR1 Q14CF2 Q5J8M2 Q5T460 Q5T462 Q68DG6 Q8N9X1 Q8NF34 Q8TEK1
Alternative splicing: 7 isoforms:  Q14CB8-1   Q14CB8-2   Q14CB8-3   Q14CB8-4   Q14CB8-5   Q14CB8-6   Q14CB8-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP19-SLIT1: NX_Q14CB8

Explore proteomics data for ARHGAP19-SLIT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14CB8

  • ARHGAP19-SLIT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP19-SLIT1 Protein Expression

    ENSEMBL proteins: 
     ENSP00000473567   ENSP00000414774   ENSP00000324468   ENSP00000351058  
    Reactome Protein details: Q14CB8
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005829cytosol ----

    ARHGAP19-SLIT1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q14CB8

    ProtoNet protein and cluster: Q14CB8

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP19-SLIT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG19_HUMAN, Q14CB8
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
         
    ARHGAP19-SLIT1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    3        Reactome Pathways for ARHGAP19-SLIT1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP19-SLIT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP19-SLIT1

    2 Interacting proteins for ARHGAP19-SLIT1 (Q14CB82, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542522, 3MINT-2877777 I2D: score=3 
    ZNF101Q8IZC73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0051056regulation of small GTPase mediated signal transduction ----

    ARHGAP19-SLIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP19-SLIT1 (RHG19)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP19-SLIT1 / RHG19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475285 ENST00000479633 ENST00000453547(uc001kmy.3) ENST00000316676
    ENST00000358308
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See ARHGAP19-SLIT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP19-SLIT1

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary

        SABiosciences Custom PCR Arrays for ARHGAP19-SLIT1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP19-SLIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP19-SLIT1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARHGAP196
    rho GTPase-activating protein 19
    74(a)
    1 → many
    6(21907730-21926841)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    69(a)
    1 → many
    GL343810.1(136692-174669)
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap196
    Rho GTPase activating protein 19
    61(a)
    1 → many
    22(37796307-37818548)
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP102A6
    RhoGAP54D6
    RhoGAP54D
    7(a)
    11(a)
    possible ortholog
    1 ↔ many
    4(276143-285701)
    2R(13473930-13478387)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LRG16
    Putative GTPase-activating protein (GAP) involved ...
    6(a)
    1 → many
    IV(22823-25876)
            Species with no ortholog for ARHGAP19-SLIT1

    ENSEMBL Gene Tree for ARHGAP19-SLIT1 (if available)
    TreeFam Gene Tree for ARHGAP19-SLIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP19-SLIT1 gene
    ARHGAP192  

    ARHGAP19-SLIT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/667 SNPs in ARHGAP19-SLIT1 are shown (see all 667)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846791991,2
    --98947696(+) GAAGGA/GAGAGA 1 -- int10--------
    rs1453104421,2
    C--98947719(+) CAGGCA/GACATG 1 -- int10--------
    rs70738211,2
    C,F,A,H--98947742(+) CAGAGT/CGACAG 1 -- int17Minor allele frequency- C:0.06NS EA WA 540
    rs70901091,2
    C,F--98947768(+) GGAAGG/AGTGGG 1 -- int13Minor allele frequency- A:0.11WA 122
    rs37585861,2
    C,F,A--98947970(-) GGCTGC/TTGGGG 1 -- int16Minor allele frequency- T:0.22WA CSA NA EA 364
    rs1899457291,2
    --98948151(+) TGGCCA/GCACAC 1 -- int10--------
    rs37813741,2
    C,F,A,H--98948159(-) GCTTGG/CGGGTG 1 -- int17Minor allele frequency- C:0.23WA NA CSA EA 366
    rs1922040681,2
    C--98948179(+) TTTTTC/TCAATT 1 -- int10--------
    rs7018021,2
    C,F,A--98948238(+) CAGCCG/AGGCCA 1 -- int17Minor allele frequency- A:0.19NA WA EA 366
    rs1836585841,2
    --98948307(+) ATACTA/CCACCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGAP19-SLIT1 (98757795 - 99007795 bp, first 250kb of ARHGAP19-SLIT1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ARHGAP19-SLIT1 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739840CNV Deletion23290073
    esv2739862CNV Deletion23290073
    esv2739829CNV Deletion23290073
    esv2304672CNV Deletion18987734
    esv1003170CNV Deletion20482838
    esv5077CNV Deletion18987735
    esv1001501CNV Deletion20482838
    esv2429720CNV Deletion19546169
    esv1315028CNV Deletion17803354
    esv2739851CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP19-SLIT1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARHGAP19-SLIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PubMed id 17454002)2 Lv L.... Mao Y. (2007)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100533184 HGNC: 48348 Ensembl:ENSG00000269891 euGenes: HUgn100533184 ECgene: ARHGAP19-SLIT1
    H-InvDB: ARHGAP19-SLIT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP19-SLIT1 gene:
    Search GeneIP for patents involving ARHGAP19-SLIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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