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ARHGAP19 Gene

protein-coding   GIFtS: 54
GCID: GC10M098971

Rho GTPase Activating Protein 19

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 191 2
Rho-Type GTPase-Activating Protein 192 3
Putative RhoGAP Protein2
Rho GTPase-Activating Protein 192

External Ids:    HGNC: 237241   Entrez Gene: 849862   Ensembl: ENSG000002133907   OMIM: 6115875   UniProtKB: Q14CB83   

Export aliases for ARHGAP19 gene to outside databases

Previous GC identifers: GC10M098646 GC10M098748 GC10M092610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP19 Gene:
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390),
which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle
progression (Lv et al., 2007 (PubMed 17454002)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARHGAP19 Gene:
ARHGAP19 (Rho GTPase activating protein 19) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)

Gene Wiki entry for ARHGAP19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP19 gene promoter:
         GR   RFX1   GR-beta   HTF   Bach2   HNF-4alpha2   Gfi-1   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP19 promoter sequence
   Search Chromatin IP Primers for ARHGAP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.2

ARHGAP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP19 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098971:  view genomic region     (about GC identifiers)

Start:
98,978,996 bp from pter      End:
99,052,430 bp from pter
Size:
73,435 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 19  
Size: 494 amino acids; 55756 Da
Sequence caution: Sequence=BAB84948.1; Type=Erroneous initiation; Sequence=BAC04165.1; Type=Frameshift;
Positions=280;
Secondary accessions: A1XCP1 B4DZR1 Q14CF2 Q5J8M2 Q5T460 Q5T462 Q68DG6 Q8N9X1 Q8NF34 Q8TEK1
Alternative splicing: 7 isoforms:  Q14CB8-1   Q14CB8-2   Q14CB8-3   Q14CB8-4   Q14CB8-5   Q14CB8-6   Q14CB8-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP19: NX_Q14CB8

Explore proteomics data for ARHGAP19 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48
  • Modification sites at PhosphoSitePlus

  • See ARHGAP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191229.1  NP_001243352.1  NP_116289.4  

    ENSEMBL proteins: 
     ENSP00000473327   ENSP00000351333   ENSP00000360066   ENSP00000473667   ENSP00000347526  
    Reactome Protein details: Q14CB8

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    Cloud-Clone Corp. Proteins for ARHGAP19

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q14CB8

    ProtoNet protein and cluster: Q14CB8

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG19_HUMAN, Q14CB8
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    Find genes that share ontologies with ARHGAP19           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arhgap19):
     no phenotypic analysis  normal 

    Find genes that share phenotypes with ARHGAP19           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP19
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    Block miRNA regulation of human, mouse, rat ARHGAP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP19 (see all 42):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-1321 hsa-miR-429 hsa-miR-128 hsa-miR-192 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP19 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG19_HUMAN, Q14CB8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARHGAP19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP19 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with ARHGAP19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP19
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP19
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP19 (Q14CB82, 3 ENSP000003513334) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542522, 3, ENSP000003523244MINT-2877777 I2D: score=3 STRING: ENSP00000352324
    ZNF101Q8IZC73I2D: score=1 
    ARHGEF38ENSP000002651544STRING: ENSP00000416125 STRING: ENSP00000265154
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP19 (RHG19)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP19 gene (3 alternative transcripts): 
    NM_001204300.1  NM_001256423.1  NM_032900.5  

    Unigene Cluster for ARHGAP19:

    Rho GTPase activating protein 19
    Hs.80305  [show with all ESTs]
    Unigene Representative Sequence: NM_032900
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492211(uc009xvi.3) ENST00000358531(uc001kna.3 uc001knb.3 uc009xvj.3 uc009xvk.3)
    ENST00000487035 ENST00000371027 ENST00000466484 ENST00000493068 ENST00000355366

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP19 (see all 42):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-1321 hsa-miR-429 hsa-miR-128 hsa-miR-192 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP19 3' UTR sequence
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    Additional mRNA sequence: 

    AK074122.1 AK093316.1 AK093441.1 AK097919.1 AK303055.1 BC007848.1 BC082250.1 BC103749.1 
    BC113888.1 BC114490.1 BX648189.1 BX648194.1 CR749412.1 DQ338460.1 NR_037909.1 U79256.1 

    9 DOTS entries:

    DT.121265949  DT.452031  DT.315384  DT.121265950  DT.101956670  DT.100761650  DT.40258982  DT.99927327 
    DT.101970544 

    Selected AceView cDNA sequences (see all 171):

    AW468117 BG944425 BC082250 BG257541 AA902185 AA463796 BQ213309 BM552064 
    BX282510 BF313786 BU158148 BX279828 BM677682 AA654445 BG940955 AA442812 
    BU685440 AA828422 AK090447 AA341668 AI057321 BQ920986 AL046152 F13383 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP19 Expression
    About this image

    ARHGAP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80305

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP19 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap191 , 5 Rho GTPase activating protein 191, 5 86.1(n)1
    87.85(a)1
      19 (35.19 cM)5
    710851  NM_027667.31  NP_081943.21 
     417665885 
    chicken
    (Gallus gallus)
    Aves ARHGAP191 Rho GTPase activating protein 19 72.9(n)
    78.57(a)
      423846  NM_001012909.1  NP_001012927.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    GL343810.1(136692-174669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.6352 Transcribed sequence with weak similarity to protein more 70.78(n)    AL869146.2 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap191 Rho GTPase activating protein 19 62.8(n)
    64.77(a)
      100537002  XM_003201138.2  XP_003201186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP54D1 RhoGAP54D 44.03(n)
    33.96(a)
      36996  NM_137392.2  NP_611236.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGA16
    RGA26
    GTPase-activating protein for the polarity-establi...
    GTPase-activating protein for the polarity-establi...
    5(a)
    5(a)
    many ↔ many
    many ↔ many
    XV(561170-564193) YOR127W
    IV(1230167-1233196) YDR379W


    ENSEMBL Gene Tree for ARHGAP19 (if available)
    TreeFam Gene Tree for ARHGAP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP19 gene
    ARHGAP292  HMHA12  GMIP2  ARHGAP19-SLIT12  
    5 SIMAP similar genes for ARHGAP19 using alignment to 4 protein entries:     RHG19_HUMAN (see all proteins):
    ARHGAP19-SLIT1    ARHGAP23    ARHGAP21    ARHGAP24    ARHGAP12

    Find genes that share paralogs with ARHGAP19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for ARHGAP19    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171125981,2,4
    ----see VAR_0311522 mis40--------

    HapMap Linkage Disequilibrium report for ARHGAP19 (98978996 - 99052430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP19 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5077CNV Deletion18987735
    esv2429720CNV Deletion19546169
    esv1001501CNV Deletion20482838
    esv1315028CNV Deletion17803354
    esv2739862CNV Deletion23290073
    esv2739851CNV Deletion23290073
    esv1003170CNV Deletion20482838
    esv2304672CNV Deletion18987734
    nsv512179CNV Loss21212237
    esv6307CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611587    OMIM disorders: --


    Find genes that share disorders with ARHGAP19           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP19
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP19 (1 document)

    Export disorders for ARHGAP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP19 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ARHGAP19)
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    1. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PubMed id 17454002)1, 2 Lv L.... Mao Y. (DNA Seq. 2007)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84986 HGNC: 23724 AceView: ARHGAP19 Ensembl:ENSG00000213390 euGenes: HUgn84986
    ECgene: ARHGAP19 H-InvDB: ARHGAP19

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP19 gene:
    Search GeneIP for patents involving ARHGAP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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