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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP19 Gene

protein-coding   GIFtS: 54
GCID: GC10M098971

Rho GTPase Activating Protein 19

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Rho GTPase Activating Protein 191 2
Rho-Type GTPase-Activating Protein 192 3
Putative RhoGAP Protein2
Rho GTPase-Activating Protein 192

External Ids:    HGNC: 237241   Entrez Gene: 849862   Ensembl: ENSG000002133907   OMIM: 6115875   UniProtKB: Q14CB83   
ORGUL members:         
NONCODE14:n410662      

Export aliases for ARHGAP19 gene to outside databases

Previous GC identifers: GC10M098646 GC10M098748 GC10M092610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP19 Gene:
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390),
which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle
progression (Lv et al., 2007 (PubMed 17454002)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARHGAP19 Gene: 
ARHGAP19 (Rho GTPase activating protein 19) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ARHGAP19 include alzheimer's disease, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP19-SLIT1.

UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)

Gene Wiki entry for ARHGAP19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP19 gene promoter:
         GR   RFX1   GR-beta   HTF   Bach2   HNF-4alpha2   Gfi-1   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP19 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.2

ARHGAP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP19 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098971:  view genomic region     (about GC identifiers)

Start:
98,978,996 bp from pter      End:
99,052,430 bp from pter
Size:
73,435 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 19  
Size: 494 amino acids; 55756 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB84948.1; Type=Erroneous initiation; Sequence=BAC04165.1; Type=Frameshift;
Positions=280;
Secondary accessions: A1XCP1 B4DZR1 Q14CF2 Q5J8M2 Q5T460 Q5T462 Q68DG6 Q8N9X1 Q8NF34 Q8TEK1
Alternative splicing: 7 isoforms:  Q14CB8-1   Q14CB8-2   Q14CB8-3   Q14CB8-4   Q14CB8-5   Q14CB8-6   Q14CB8-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP19: NX_Q14CB8

Explore proteomics data for ARHGAP19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14CB8

  • ARHGAP19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP19 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001191229.1  NP_001243352.1  NP_116289.4  

    ENSEMBL proteins: 
     ENSP00000473327   ENSP00000351333   ENSP00000360066   ENSP00000473667   ENSP00000347526  
    Reactome Protein details: Q14CB8
    Human Recombinant Protein Products for ARHGAP19: 
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    Cloud-Clone Corp. Proteins for ARHGAP19 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    ARHGAP19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q14CB8

    ProtoNet protein and cluster: Q14CB8

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG19_HUMAN, Q14CB8
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    ARHGAP19 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arhgap19):
     no phenotypic analysis  normal 

    ARHGAP19 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGAP19 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ARHGAP19
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP19 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for ARHGAP19 (Q14CB82, 3 ENSP000003513334) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542522, 3, ENSP000003523244MINT-2877777 I2D: score=3 STRING: ENSP00000352324
    ZNF101Q8IZC73I2D: score=1 
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ECT2ENSP000002324584STRING: ENSP00000232458
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP19 (RHG19)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP19 / RHG19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP19 gene (3 alternative transcripts): 
    NM_001204300.1  NM_001256423.1  NM_032900.5  

    Unigene Cluster for ARHGAP19:

    Rho GTPase activating protein 19
    Hs.80305  [show with all ESTs]
    Unigene Representative Sequence: NM_032900
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492211(uc009xvi.3) ENST00000358531(uc001kna.3 uc001knb.3 uc009xvj.3 uc009xvk.3)
    ENST00000487035 ENST00000371027 ENST00000466484 ENST00000493068 ENST00000355366


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    Additional mRNA sequence: 

    AK074122.1 AK093316.1 AK093441.1 AK097919.1 AK303055.1 BC007848.1 BC082250.1 BC103749.1 
    BC113888.1 BC114490.1 BX648189.1 BX648194.1 CR749412.1 DQ338460.1 NR_037909.1 U79256.1 

    9 DOTS entries:

    DT.121265949  DT.452031  DT.315384  DT.121265950  DT.101956670  DT.100761650  DT.40258982  DT.99927327 
    DT.101970544 

    24/171 AceView cDNA sequences (see all 171):

    BG940955 BF313786 BQ422689 AA463796 AI057321 AL046152 F13383 BQ071277 
    F11560 BG393413 BC082250 F10974 BM904632 BU158148 BX279828 AK074122 
    AA902185 BM677682 AA887134 BC007848 BM552064 AA341668 BE278749 BX282510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGAP19 Expression
    About this image


    See ARHGAP19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP19

    SOURCE GeneReport for Unigene cluster: Hs.80305

    UniProtKB/Swiss-Prot: RHG19_HUMAN, Q14CB8
    Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGAP19 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap191 , 5 Rho GTPase activating protein 191, 5 86.21(n)1
    88.03(a)1
      19 (35.19 cM)5
    710851  NM_027667.31  NP_081943.21 
     417665885 
    chicken
    (Gallus gallus)
    Aves ARHGAP191 Rho GTPase activating protein 19 72.76(n)
    78.57(a)
      423846  NM_001012909.1  NP_001012927.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    69(a)
    1 → many
    GL343810.1(136692-174669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.6352 Transcribed sequence with weak similarity to protein more 70.78(n)    AL869146.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005370021 rho GTPase-activating protein 19-like 62.73(n)
    64.32(a)
      100537002  XM_003201138.1  XP_003201186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP54D1 CG6477-PA 43.94(n)
    34.41(a)
      36996  NM_137392.2  NP_611236.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LRG16
    Putative GTPase-activating protein (GAP) involved ...
    6(a)
    1 → many
    IV(22823-25876)


    ENSEMBL Gene Tree for ARHGAP19 (if available)
    TreeFam Gene Tree for ARHGAP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP19 gene
    ARHGAP19-SLIT12  
    4 SIMAP similar genes for ARHGAP19 using alignment to 6 protein entries:     RHG19_HUMAN (see all proteins):
    ARHGAP23    ARHGAP21    ARHGAP24    ARHGAP12

    ARHGAP19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in ARHGAP19 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0311524
    ----see VAR_0311522 Q R mis40--------

    HapMap Linkage Disequilibrium report for ARHGAP19 (98978996 - 99052430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ARHGAP19 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv5077CNV Deletion18987735
    esv2429720CNV Deletion19546169
    esv1001501CNV Deletion20482838
    esv1315028CNV Deletion17803354
    esv2739862CNV Deletion23290073
    esv2739851CNV Deletion23290073
    esv1003170CNV Deletion20482838
    esv2304672CNV Deletion18987734
    nsv512179CNV Loss21212237
    esv6307CNV Loss19470904

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611587    OMIM disorders: --

    2 diseases for ARHGAP19:    About MalaCards
    alzheimer's disease    


    ARHGAP19 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ARHGAP19
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP19 (1 document)

    Export disorders for ARHGAP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP19 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ARHGAP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PubMed id 17454002)1, 2 Lv L.... Mao Y. (2007)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84986 HGNC: 23724 AceView: ARHGAP19 Ensembl:ENSG00000213390 euGenes: HUgn84986
    ECgene: ARHGAP19 H-InvDB: ARHGAP19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP19 gene:
    Search GeneIP for patents involving ARHGAP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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