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Aliases for ARHGAP19 Gene

Aliases for ARHGAP19 Gene

  • Rho GTPase Activating Protein 19 2 3 5
  • Rho-Type GTPase-Activating Protein 19 4

External Ids for ARHGAP19 Gene

Previous GeneCards Identifiers for ARHGAP19 Gene

  • GC10M098646
  • GC10M098971
  • GC10M098748
  • GC10M092610

Summaries for ARHGAP19 Gene

Entrez Gene Summary for ARHGAP19 Gene

  • Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP19 Gene

ARHGAP19 (Rho GTPase Activating Protein 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP19-SLIT1.

UniProtKB/Swiss-Prot for ARHGAP19 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP19 Gene

Genomics for ARHGAP19 Gene

Regulatory Elements for ARHGAP19 Gene

Enhancers for ARHGAP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F097267 1 ENCODE 26.7 +24.2 24228 2.3 SCRT2 ARHGAP19 SLIT1 RRP12 ENSG00000231398 LOC105378447
GH10F097258 0.2 ENCODE 25.6 +32.6 32566 3.8 PKNOX1 ZNF600 SLIT1 ARHGAP19 SLIT1-AS1 ENSG00000231398 LOC105378447
GH10F097222 0.4 ENCODE 24.6 +70.2 70185 0.2 HDAC1 RFX1 MAX ARID1B GATA2 IKZF1 MYNN HMBOX1 ARHGAP19 SLIT1 SLIT1-AS1 LOC105378447 ENSG00000231398
GH10F097355 0.8 Ensembl ENCODE 24.3 -63.6 -63596 2.1 SRF CTCF ZNF654 E2F5 USF2 MAX REST RAD21 RAD51 SMC3 RRP12 ARHGAP19 SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 PI4K2A PGAM1 FRAT2
GH10F097353 1.1 FANTOM5 Ensembl 24.3 -61.6 -61628 1.4 CTCF RRP12 ARHGAP19 PI4K2A SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 FRAT1 FRAT2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222050 473 2000 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ARHGAP19 Gene

Chromosome:
10
Start:
97,222,173 bp from pter
End:
97,292,673 bp from pter
Size:
70,501 bases
Orientation:
Minus strand

Genomic View for ARHGAP19 Gene

Genes around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP19 Gene

Proteins for ARHGAP19 Gene

  • Protein details for ARHGAP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CB8-RHG19_HUMAN
    Recommended name:
    Rho GTPase-activating protein 19
    Protein Accession:
    Q14CB8
    Secondary Accessions:
    • A1XCP1
    • B4DZR1
    • Q14CF2
    • Q5J8M2
    • Q5T460
    • Q5T462
    • Q68DG6
    • Q8N9X1
    • Q8NF34
    • Q8TEK1

    Protein attributes for ARHGAP19 Gene

    Size:
    494 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04165.1; Type=Frameshift; Positions=280; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP19 Gene

neXtProt entry for ARHGAP19 Gene

Post-translational modifications for ARHGAP19 Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP19 Gene

No data available for DME Specific Peptides for ARHGAP19 Gene

Domains & Families for ARHGAP19 Gene

Gene Families for ARHGAP19 Gene

Protein Domains for ARHGAP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q14CB8

UniProtKB/Swiss-Prot:

RHG19_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP19: view

Function for ARHGAP19 Gene

Molecular function for ARHGAP19 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view
genes like me logo Genes that share phenotypes with ARHGAP19: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP19 Gene

Localization for ARHGAP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP19 Gene COMPARTMENTS Subcellular localization image for ARHGAP19 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view

Pathways & Interactions for ARHGAP19 Gene

genes like me logo Genes that share pathways with ARHGAP19: view

Pathways by source for ARHGAP19 Gene

1 GeneTex pathway for ARHGAP19 Gene
3 Reactome pathways for ARHGAP19 Gene

Gene Ontology (GO) - Biological Process for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view

No data available for SIGNOR curated interactions for ARHGAP19 Gene

Transcripts for ARHGAP19 Gene

Unigene Clusters for ARHGAP19 Gene

Rho GTPase activating protein 19:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP19 Gene

No ASD Table

Relevant External Links for ARHGAP19 Gene

GeneLoc Exon Structure for
ARHGAP19
ECgene alternative splicing isoforms for
ARHGAP19

Expression for ARHGAP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP19 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP19 Gene

This gene is overexpressed in Nerve - Tibial (x6.7).

Protein differential expression in normal tissues from HIPED for ARHGAP19 Gene

This gene is overexpressed in Bone (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP19 Gene



Protein tissue co-expression partners for ARHGAP19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP19 Gene:

ARHGAP19

SOURCE GeneReport for Unigene cluster for ARHGAP19 Gene:

Hs.80305

mRNA Expression by UniProt/SwissProt for ARHGAP19 Gene:

Q14CB8-RHG19_HUMAN
Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.
genes like me logo Genes that share expression patterns with ARHGAP19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGAP19 Gene

Orthologs for ARHGAP19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP19 34
  • 99.32 (n)
-- 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
ARHGAP19 34
  • 91.97 (n)
cow
(Bos Taurus)
Mammalia ARHGAP19 34
  • 90.24 (n)
-- 35
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Arhgap19 34 16 35
  • 86.1 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap19 34
  • 85.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP19 34 35
  • 72.9 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap19 34
  • 65.82 (n)
Str.635 34
zebrafish
(Danio rerio)
Actinopterygii arhgap19 34 35
  • 62.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001687 34
  • 44.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP54D 34 35
  • 44.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 35
  • 5 (a)
ManyToMany
RGA2 35
  • 5 (a)
ManyToMany
Species where no ortholog for ARHGAP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP19 Gene

ENSEMBL:
Gene Tree for ARHGAP19 (if available)
TreeFam:
Gene Tree for ARHGAP19 (if available)

Paralogs for ARHGAP19 Gene

(5) SIMAP similar genes for ARHGAP19 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARHGAP19: view

Variants for ARHGAP19 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP19 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10466168 -- 97,273,120(+) caggc(A/G)tgagc intron-variant
rs10592924 -- 97,234,436(+) AAAAA(-/AA)GATAC intron-variant
rs10736115 -- 97,271,928(+) TATTG(C/T)TAAAC intron-variant, upstream-variant-2KB
rs10748691 -- 97,224,198(+) ACTTC(A/G)GGATG intron-variant, utr-variant-3-prime
rs10748692 -- 97,273,086(+) CCGCC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP19 Gene

Variant ID Type Subtype PubMed ID
dgv503n106 CNV deletion 24896259
esv1001501 CNV deletion 20482838
esv1003170 CNV deletion 20482838
esv1315028 CNV deletion 17803354
esv2304672 CNV deletion 18987734
esv2429720 CNV deletion 19546169
esv2739851 CNV deletion 23290073
esv2739862 CNV deletion 23290073
esv3261163 CNV deletion 24192839
esv3546724 CNV deletion 23714750
esv3624311 CNV loss 21293372
esv5077 CNV loss 18987735
esv6307 CNV loss 19470904
nsv1040903 CNV gain 25217958
nsv1069066 CNV deletion 25765185
nsv1069067 CNV deletion 25765185
nsv1070883 CNV deletion 25765185
nsv1110852 OTHER inversion 24896259
nsv1127135 CNV deletion 24896259
nsv1150585 CNV deletion 26484159
nsv473431 CNV novel sequence insertion 20440878
nsv512179 CNV loss 21212237
nsv7507 CNV deletion 18451855
nsv831952 CNV loss 17160897
nsv950999 CNV deletion 24416366
nsv955563 CNV deletion 24416366

Variation tolerance for ARHGAP19 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Disorders for ARHGAP19 Gene

Relevant External Links for ARHGAP19

Genetic Association Database (GAD)
ARHGAP19
Human Genome Epidemiology (HuGE) Navigator
ARHGAP19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP19

No disorders were found for ARHGAP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP19 Gene

Publications for ARHGAP19 Gene

  1. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PMID: 17454002) Lv L. … Mao Y. (DNA Seq. 2007) 3 4 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARHGAP19 Gene

Sources for ARHGAP19 Gene

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