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Aliases for ARHGAP19 Gene

Aliases for ARHGAP19 Gene

  • Rho GTPase Activating Protein 19 2 3 5
  • Rho-Type GTPase-Activating Protein 19 4

External Ids for ARHGAP19 Gene

Previous GeneCards Identifiers for ARHGAP19 Gene

  • GC10M098646
  • GC10M098971
  • GC10M098748
  • GC10M092610

Summaries for ARHGAP19 Gene

Entrez Gene Summary for ARHGAP19 Gene

  • Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP19 Gene

ARHGAP19 (Rho GTPase Activating Protein 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP19 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP19 Gene

Genomics for ARHGAP19 Gene

Regulatory Elements for ARHGAP19 Gene

Promoters for ARHGAP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP19 Gene

Chromosome:
10
Start:
97,222,173 bp from pter
End:
97,292,673 bp from pter
Size:
70,501 bases
Orientation:
Minus strand

Genomic View for ARHGAP19 Gene

Genes around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP19 Gene

Proteins for ARHGAP19 Gene

  • Protein details for ARHGAP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CB8-RHG19_HUMAN
    Recommended name:
    Rho GTPase-activating protein 19
    Protein Accession:
    Q14CB8
    Secondary Accessions:
    • A1XCP1
    • B4DZR1
    • Q14CF2
    • Q5J8M2
    • Q5T460
    • Q5T462
    • Q68DG6
    • Q8N9X1
    • Q8NF34
    • Q8TEK1

    Protein attributes for ARHGAP19 Gene

    Size:
    494 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04165.1; Type=Frameshift; Positions=280; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP19 Gene

neXtProt entry for ARHGAP19 Gene

Proteomics data for ARHGAP19 Gene at MOPED

Post-translational modifications for ARHGAP19 Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP19 Gene

Antibody Products

No data available for DME Specific Peptides for ARHGAP19 Gene

Domains & Families for ARHGAP19 Gene

Gene Families for ARHGAP19 Gene

Protein Domains for ARHGAP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q14CB8

UniProtKB/Swiss-Prot:

RHG19_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP19: view

Function for ARHGAP19 Gene

Molecular function for ARHGAP19 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
genes like me logo Genes that share phenotypes with ARHGAP19: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP19 Gene

Localization for ARHGAP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP19 Gene COMPARTMENTS Subcellular localization image for ARHGAP19 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ARHGAP19 Gene

Pathways & Interactions for ARHGAP19 Gene

genes like me logo Genes that share pathways with ARHGAP19: view

Pathways by source for ARHGAP19 Gene

1 GeneTex pathway for ARHGAP19 Gene
3 Reactome pathways for ARHGAP19 Gene

Gene Ontology (GO) - Biological Process for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view

No data available for SIGNOR curated interactions for ARHGAP19 Gene

Drugs & Compounds for ARHGAP19 Gene

No Compound Related Data Available

Transcripts for ARHGAP19 Gene

Unigene Clusters for ARHGAP19 Gene

Rho GTPase activating protein 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP19 Gene

No ASD Table

Relevant External Links for ARHGAP19 Gene

GeneLoc Exon Structure for
ARHGAP19
ECgene alternative splicing isoforms for
ARHGAP19

Expression for ARHGAP19 Gene

mRNA expression in normal human tissues for ARHGAP19 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP19 Gene

This gene is overexpressed in Nerve - Tibial (x6.7).

Protein differential expression in normal tissues from HIPED for ARHGAP19 Gene

This gene is overexpressed in Bone (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP19 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP19 Gene Hs.80305

mRNA Expression by UniProt/SwissProt for ARHGAP19 Gene

Q14CB8-RHG19_HUMAN
Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.
genes like me logo Genes that share expression patterns with ARHGAP19: view

Protein tissue co-expression partners for ARHGAP19 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGAP19 Gene

Orthologs for ARHGAP19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP19 35
  • 90.24 (n)
  • 92.68 (a)
-- 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ARHGAP19 35
  • 91.97 (n)
  • 94.94 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Arhgap19 35
  • 86.1 (n)
  • 87.85 (a)
Arhgap19 16
Arhgap19 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP19 35
  • 99.32 (n)
  • 99.8 (a)
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgap19 35
  • 85.96 (n)
  • 88.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP19 35
  • 72.9 (n)
  • 78.57 (a)
ARHGAP19 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap19 35
  • 65.82 (n)
  • 70.21 (a)
Str.635 35
zebrafish
(Danio rerio)
Actinopterygii arhgap19 35
  • 62.8 (n)
  • 64.77 (a)
arhgap19 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001687 35
  • 44.5 (n)
  • 32.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP54D 35
  • 44.03 (n)
  • 33.96 (a)
RhoGAP54D 36
  • 6 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 36
  • 5 (a)
ManyToMany
RGA2 36
  • 5 (a)
ManyToMany
Species with no ortholog for ARHGAP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP19 Gene

ENSEMBL:
Gene Tree for ARHGAP19 (if available)
TreeFam:
Gene Tree for ARHGAP19 (if available)

Paralogs for ARHGAP19 Gene

(5) SIMAP similar genes for ARHGAP19 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARHGAP19: view

Variants for ARHGAP19 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP19 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_031152 -

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP19 Gene

Variant ID Type Subtype PubMed ID
esv2739851 CNV Deletion 23290073
nsv831952 CNV Loss 17160897
nsv895914 CNV Gain 21882294
nsv7507 CNV Loss 18451855
esv1003170 CNV Deletion 20482838
esv2429720 CNV Deletion 19546169
esv2304672 CNV Deletion 18987734
nsv512179 CNV Loss 21212237
esv5077 CNV Deletion 18987735
esv2739862 CNV Deletion 23290073
esv6307 CNV Loss 19470904
esv1001501 CNV Deletion 20482838
esv1315028 CNV Deletion 17803354

Variation tolerance for ARHGAP19 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP19 Gene

HapMap Linkage Disequilibrium report
ARHGAP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Disorders for ARHGAP19 Gene

Relevant External Links for ARHGAP19

Genetic Association Database (GAD)
ARHGAP19
Human Genome Epidemiology (HuGE) Navigator
ARHGAP19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP19

No disorders were found for ARHGAP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP19 Gene

Publications for ARHGAP19 Gene

  1. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PMID: 17454002) Lv L. … Mao Y. (DNA Seq. 2007) 3 4 67
  2. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ARHGAP19 Gene

Sources for ARHGAP19 Gene

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