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Aliases for ARHGAP18 Gene

Aliases for ARHGAP18 Gene

  • Rho GTPase Activating Protein 18 2 3
  • Rho-Type GTPase-Activating Protein 18 3 4
  • MacGAP 3 4
  • Rho GTPase-Activating Protein 18 3
  • BA307O14.2 3
  • SENEX 3

External Ids for ARHGAP18 Gene

Previous GeneCards Identifiers for ARHGAP18 Gene

  • GC06M129832
  • GC06M129878
  • GC06M129939
  • GC06M127478
  • GC06M129897

Summaries for ARHGAP18 Gene

Entrez Gene Summary for ARHGAP18 Gene

  • ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]

GeneCards Summary for ARHGAP18 Gene

ARHGAP18 (Rho GTPase Activating Protein 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP18 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP18 Gene

Genomics for ARHGAP18 Gene

Regulatory Elements for ARHGAP18 Gene

Genomic Location for ARHGAP18 Gene

Start:
129,576,132 bp from pter
End:
129,710,225 bp from pter
Size:
134,094 bases
Orientation:
Minus strand

Genomic View for ARHGAP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP18 Gene

Proteins for ARHGAP18 Gene

  • Protein details for ARHGAP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N392-RHG18_HUMAN
    Recommended name:
    Rho GTPase-activating protein 18
    Protein Accession:
    Q8N392
    Secondary Accessions:
    • E1P575
    • Q58EZ3
    • Q6P679
    • Q6PJD7
    • Q96S64

    Protein attributes for ARHGAP18 Gene

    Size:
    663 amino acids
    Molecular mass:
    74977 Da
    Quaternary structure:
    • Interacts with MPHOSPH6.
    SequenceCaution:
    • Sequence=AAH17223.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH39611.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62417.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB61887.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP18 Gene

Proteomics data for ARHGAP18 Gene at MOPED

Post-translational modifications for ARHGAP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP18 Gene

Domains for ARHGAP18 Gene

Gene Families for ARHGAP18 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP18 Gene

Suggested Antigen Peptide Sequences for ARHGAP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N392

UniProtKB/Swiss-Prot:

RHG18_HUMAN :
  • Q8N392
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP18: view

Function for ARHGAP18 Gene

Molecular function for ARHGAP18 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP18: view

Phenotypes for ARHGAP18 Gene

MGI mutant phenotypes for ARHGAP18:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARHGAP18:
genes like me logo Genes that share phenotypes with ARHGAP18: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP18 Gene

Localization for ARHGAP18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP18 Gene COMPARTMENTS Subcellular localization image for ARHGAP18 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP18 Gene

Pathways for ARHGAP18 Gene

genes like me logo Genes that share pathways with ARHGAP18: view

Pathways by source for ARHGAP18 Gene

3 Reactome pathways for ARHGAP18 Gene

Interacting Proteins for ARHGAP18 Gene

Selected Interacting proteins: Q8N392-RHG18_HUMAN for ARHGAP18 Gene via I2D

Symbol External ID(s) Details
MPHOSPH6
MPP6

Gene Ontology (GO) - Biological Process for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP18: view

Transcripts for ARHGAP18 Gene

Unigene Clusters for ARHGAP18 Gene

Rho GTPase activating protein 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP18 Gene

No ASD Table

Relevant External Links for ARHGAP18 Gene

GeneLoc Exon Structure for
ARHGAP18
ECgene alternative splicing isoforms for
ARHGAP18

Expression for ARHGAP18 Gene

mRNA expression in normal human tissues for ARHGAP18 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP18 Gene

This gene is overexpressed in Adrenal Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGAP18 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP18 Gene Hs.486458

genes like me logo Genes that share expressions with ARHGAP18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGAP18 Gene

Orthologs for ARHGAP18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP18 35
  • 99.2 (n)
  • 98.94 (a)
ARHGAP18 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP18 35
  • 88.8 (n)
  • 87.48 (a)
ARHGAP18 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP18 35
  • 89.01 (n)
  • 90.41 (a)
ARHGAP18 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap18 35
  • 84.8 (n)
  • 85.3 (a)
Arhgap18 16
Arhgap18 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP18 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgap18 35
  • 84.94 (n)
  • 85.8 (a)
chicken
(Gallus gallus)
Aves ARHGAP18 35
  • 74.68 (n)
  • 75.19 (a)
ARHGAP18 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP18 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18124 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734415 35
  • 66.22 (n)
  • 65.64 (a)
zebrafish
(Danio rerio)
Actinopterygii ARHGAP18 36
  • 52 (a)
OneToOne
LOC100004252 35
  • 60.11 (n)
  • 59.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for ARHGAP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP18 Gene

ENSEMBL:
Gene Tree for ARHGAP18 (if available)
TreeFam:
Gene Tree for ARHGAP18 (if available)

Paralogs for ARHGAP18 Gene

Selected SIMAP similar genes for ARHGAP18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP18: view

Variants for ARHGAP18 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs763132 -- 129,699,202(-) TCTTG(G/T)GACTT intron-variant
rs929102 -- 129,672,089(-) GTGTA(C/T)GTGTG intron-variant
rs929103 -- 129,672,017(-) TGTGA(A/G)TGTTG intron-variant
rs1016822 -- 129,702,161(-) GTCCA(C/G)TAAGT intron-variant
rs1023480 -- 129,703,055(-) CCATG(C/T)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP18 Gene

Variant ID Type Subtype PubMed ID
nsv886656 CNV Loss 21882294
nsv524782 CNV Loss 19592680
esv2659313 CNV Deletion 23128226
esv2639935 CNV Insertion 19546169
esv1498345 CNV Deletion 17803354
esv1584644 CNV Deletion 17803354
esv1575536 CNV Deletion 17803354
esv2732697 CNV Deletion 23290073
nsv830805 CNV Gain 17160897
nsv886657 CNV Loss 21882294
nsv522152 CNV Gain 19592680

Relevant External Links for ARHGAP18 Gene

HapMap Linkage Disequilibrium report
ARHGAP18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP18 Gene

Disorders for ARHGAP18 Gene

(1) University of Copenhagen DISEASES for ARHGAP18 Gene

Relevant External Links for ARHGAP18

Genetic Association Database (GAD)
ARHGAP18
Human Genome Epidemiology (HuGE) Navigator
ARHGAP18
genes like me logo Genes that share disorders with ARHGAP18: view

No data available for UniProtKB/Swiss-Prot for ARHGAP18 Gene

Publications for ARHGAP18 Gene

  1. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 48
  2. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PMID: 19065146) Potkin S.G. … Macciardi F. (Mol. Psychiatry 2009) 3 48
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARHGAP18 Gene

Sources for ARHGAP18 Gene

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