Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARHGAP18 Gene

protein-coding   GIFtS: 52
GCID: GC06M129897

Rho GTPase Activating Protein 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Rho GTPase Activating Protein 181 2
Rho-Type GTPase-Activating Protein 182 3
MacGAP2 3
SENEX2
bA307O14.22
Rho GTPase-Activating Protein 182

External Ids:    HGNC: 210351   Entrez Gene: 936632   Ensembl: ENSG000001463767   OMIM: 6133515   UniProtKB: Q8N3923   

Export aliases for ARHGAP18 gene to outside databases

Previous GC identifers: GC06M129832 GC06M129878 GC06M129939 GC06M127478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARHGAP18 Gene:
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling
(Potkin et al., 2009 (PubMed 19065146)).(supplied by OMIM, Apr 2010)

GeneCards Summary for ARHGAP18 Gene:
ARHGAP18 (Rho GTPase activating protein 18) is a protein-coding gene. Diseases associated with ARHGAP18 include intellectual disability, and vasculitis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP36.

UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP18 gene promoter:
         TBP   RORalpha1   SRY   S8   SREBP-1a   FOXJ2 (long isoform)   Chx10   FOXJ2   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP18 promoter sequence
   Search Chromatin IP Primers for ARHGAP18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33   Ensembl cytogenetic band:  6q22.33   HGNC cytogenetic band: 6q23.1

ARHGAP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP18 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M129897:  view genomic region     (about GC identifiers)

Start:
129,897,277 bp from pter      End:
130,031,370 bp from pter
Size:
134,094 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 18  
Size: 663 amino acids; 74977 Da
Subunit: Interacts with MPHOSPH6
Sequence caution: Sequence=AAH17223.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH39611.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH62417.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB61887.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E1P575 Q58EZ3 Q6P679 Q6PJD7 Q96S64
Alternative splicing: 2 isoforms:  Q8N392-1   Q8N392-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP18: NX_Q8N392

Explore proteomics data for ARHGAP18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_277050.2  
    ENSEMBL proteins: 
     ENSP00000357131  
    Reactome Protein details: Q8N392

    ARHGAP18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARHGAP18
    GenScript Custom Purified and Recombinant Proteins Services for ARHGAP18
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGAP18

    ARHGAP18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARHGAP18
    OriGene Custom Antibody Services for ARHGAP18
    Novus Biologicals ARHGAP18 Antibody
    Abcam antibodies for ARHGAP18
    Cloud-Clone Corp. Antibodies for ARHGAP18
    ThermoFisher Antibodies for ARHGAP18
    LSBio Antibodies in human, mouse, rat for ARHGAP18

    ARHGAP18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGAP18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGAP18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGAP18
    Cloud-Clone Corp. CLIAs for ARHGAP18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q8N392

    ProtoNet protein and cluster: Q8N392

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG18_HUMAN, Q8N392
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    ARHGAP18 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGAP18:
     Decreased viability with pacli  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgap18):
     mortality/aging 

    ARHGAP18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGAP18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGAP18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGAP18

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ARHGAP18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP18 (see all 11):
    hsa-miR-3163 hsa-miR-3128 hsa-miR-4251 hsa-miR-499-3p hsa-miR-183 hsa-miR-944 hsa-miR-335 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGAP18
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGAP18

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGAP18 (see all 7)
    OriGene ORF clones in mouse, rat for ARHGAP18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP18 (NM_033515)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGAP18
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGAP18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGAP18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARHGAP18 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP18
        Rho GTPase cycle



    ARHGAP18 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP18
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP18

    2 Interacting proteins for ARHGAP18 (Q8N3923) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPHOSPH6Q995473I2D: score=3 
    MPP6Q9NZW53I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGAP18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP18 (RHG18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARHGAP18 gene: 
    NM_033515.2  

    Unigene Cluster for ARHGAP18:

    Rho GTPase activating protein 18
    Hs.486458  [show with all ESTs]
    Unigene Representative Sequence: NM_033515
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368149 ENST00000483367 ENST00000463225
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGAP18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP18 (see all 11):
    hsa-miR-3163 hsa-miR-3128 hsa-miR-4251 hsa-miR-499-3p hsa-miR-183 hsa-miR-944 hsa-miR-335 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGAP18
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP18
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGAP18 (see all 7)
    OriGene ORF clones in mouse, rat for ARHGAP18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP18 (NM_033515)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARHGAP18
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP18
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP18
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP18

    Additional mRNA sequence: 

    AB053293.1 AK002195.1 AK098594.1 AK307796.1 AL834511.1 AY643712.1 BC017223.2 BC039611.1 
    BC052295.1 BC062417.1 BC073143.1 BC101708.1 BC107416.1 BC111940.1 BC143531.1 

    5 DOTS entries:

    DT.107983  DT.121328540  DT.100035030  DT.121328539  DT.121328566 

    Selected AceView cDNA sequences (see all 155):

    AA669517 BM467998 AW612901 BQ029517 BM721946 AI799104 BQ129374 AA453059 
    AI332585 AA736655 BU752916 AB053293 BU664426 BG031862 AI783545 AA421756 
    AA357393 BE502302 BQ430412 BM980534 BC062417 BM557178 BF109802 BC052295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARHGAP18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCGCCAG
    ARHGAP18 Expression
    About this image

    ARHGAP18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486458
        Custom PCR Arrays for ARHGAP18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARHGAP18
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP18
    QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP18
    QuantiFast Probe-based Assays in human, mouse, rat ARHGAP18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP18 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap181 , 5 Rho GTPase activating protein 181, 5 84.8(n)1
    85.3(a)1
      10 (14.12 cM)5
    739101  NM_176837.21  NP_789807.11 
     267534215 
    chicken
    (Gallus gallus)
    Aves ARHGAP181 Rho GTPase activating protein 18 74.68(n)
    75.19(a)
      421706  XM_419743.4  XP_419743.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP186
    Rho GTPase activating protein 18
    66(a)
    1 ↔ 1
    GL343315.1(664424-721655)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.181242 Xenopus laevis transcribed sequence with moderate similarity more 77.1(n)    BG885983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000042521 rho GTPase-activating protein 18-like 60.11(n)
    59.23(a)
      100004252  XM_001343565.5  XP_001343601.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170826
    --
    24(a)
    1 → many
    2R(631836-645548)


    ENSEMBL Gene Tree for ARHGAP18 (if available)
    TreeFam Gene Tree for ARHGAP18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARHGAP18 gene
    ARHGAP362  STARD132  ARHGAP62  ARHGAP402  DLC12  ARHGAP11A2  ARHGAP282  ARHGAP11B2  
    STARD82  
    4 SIMAP similar genes for ARHGAP18 using alignment to 1 protein entry:     RHG18_HUMAN:
    ARHGAP12    ARHGAP28    ARHGAP40    ARHGAP9

    ARHGAP18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARHGAP18 (see all 2881)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681877991,2
    C--127578701(-) AAAAA-/AAAAAAAGAG
    /AAAAAGAG/GAG
    GACAA
    1 -- int11NA 2
    rs1140736921,2
    C,F--129897810(+) CAAACG/ATTGCG 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1932305401,2
    --129897844(+) GACAAC/GCTTTT 1 -- int10--------
    rs1839194031,2
    --129897849(+) CCTTTA/TACTTA 1 -- int10--------
    rs1136802681,2
    C--129897876(+) CTATCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1881500051,2
    --129897928(+) TTTTCC/TTTTAT 1 -- int10--------
    rs1413448971,2
    C--129897980(+) TAATTA/GGGAAA 1 -- int10--------
    rs1813498351,2
    --129898048(+) AAAATG/TTGTAA 1 -- int10--------
    rs1135727991,2
    C,F--129898072(+) AAAGAC/TGAAAA 1 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs1507855331,2
    --129898133(+) GAAAAC/TAGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGAP18 (129897277 - 130031370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP18 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732697CNV Deletion23290073
    esv1584644CNV Deletion17803354
    esv2659313CNV Deletion23128226
    esv1498345CNV Deletion17803354
    esv1575536CNV Deletion17803354
    esv2639935CNV Insertion19546169
    nsv524782CNV Loss19592680
    nsv886657CNV Loss21882294
    nsv886656CNV Loss21882294
    nsv522152CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP18
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613351    OMIM disorders: --

    6 diseases for ARHGAP18:    
    About MalaCards
    intellectual disability    vasculitis    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    schizophrenia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ARHGAP18:
    Intellectual disability

    ARHGAP18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP18
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP18 (3 documents)

    Export disorders for ARHGAP18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARHGAP18 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ARHGAP18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1, 4 Cronin S....Hardiman O. (Eur. J. Hum. Genet. 2009)
    2. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PubMed id 19065146)1, 4 Potkin S.G....Macciardi F. (Mol. Psychiatry 2009)
    3. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    7. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    8. Genetically distinct subsets within ANCA-associated vasculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (N. Engl. J. Med. 2012)
    9. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. (PubMed id 21865595)1 Maeda M....Senga T. (Mol. Biol. Cell 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 93663 HGNC: 21035 AceView: ARHGAP18 Ensembl:ENSG00000146376 euGenes: HUgn93663
    ECgene: ARHGAP18 H-InvDB: ARHGAP18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARHGAP18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARHGAP18 gene:
    Search GeneIP for patents involving ARHGAP18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARHGAP18   OriGene RNAi products in human, mouse, rat for ARHGAP18  
     OriGene qPCR primer pairs and template standards for ARHGAP18   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARHGAP18  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP18   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARHGAP18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGAP18   OriGene Custom Protein Services for ARHGAP18  

     
     
     Block miRNA regulation of human, mouse, rat ARHGAP18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARHGAP18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP18 Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP18
     QuantiFast Probe-based Assays in human, mouse, rat ARHGAP18 QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP18
     Custom PCR Arrays for ARHGAP18 Search Chromatin IP Primers for ARHGAP18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP18  Search GeneGlobe Interaction Network for ARHGAP18
     Regulatory tfbs in ARHGAP18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARHGAP18 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP18
     GenScript Custom Assay Services for ARHGAP18 GenScript Custom overexpressing Cell Line Services for ARHGAP18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARHGAP18 (RHG18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARHGAP18 antibodies
     Antibodies for ARHGAP18
     See all of Abcam's Antibodies, Kits and Proteins for ARHGAP18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARHGAP18
     Antibodies for ARHGAP18
     ELISAs for ARHGAP18
     CLIAs for ARHGAP18



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGAP18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGAP18
     SwitchGear Promoter luciferase reporter plasmids for ARHGAP18
     ThermoFisher Antibodies for ARHGAP18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGAP18
     LSBio Antibodies in human, mouse, rat for ARHGAP18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGAP18 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4