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Aliases for ARHGAP18 Gene

Aliases for ARHGAP18 Gene

  • Rho GTPase Activating Protein 18 2 3 5
  • Rho-Type GTPase-Activating Protein 18 3 4
  • MacGAP 3 4
  • Rho GTPase-Activating Protein 18 3
  • BA307O14.2 3
  • SENEX 3

External Ids for ARHGAP18 Gene

Previous GeneCards Identifiers for ARHGAP18 Gene

  • GC06M129832
  • GC06M129878
  • GC06M129939
  • GC06M127478
  • GC06M129897

Summaries for ARHGAP18 Gene

Entrez Gene Summary for ARHGAP18 Gene

  • ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]

GeneCards Summary for ARHGAP18 Gene

ARHGAP18 (Rho GTPase Activating Protein 18) is a Protein Coding gene. Diseases associated with ARHGAP18 include Penicilliosis. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP40.

UniProtKB/Swiss-Prot for ARHGAP18 Gene

  • Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP18 Gene

Genomics for ARHGAP18 Gene

Regulatory Elements for ARHGAP18 Gene

Enhancers for ARHGAP18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G129677 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +26.5 26495 12.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ARHGAP18 RPL5P21 L3MBTL3 LOC102723409
GH06G129643 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.3 +64.1 64073 6.1 FOXA2 ATF1 MLX FEZF1 DMAP1 SP5 JUNB MIER2 PPARG KAT8 ARHGAP18 LOC102723409
GH06G129670 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +36.8 36824 5.4 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 CBX5 ZNF143 FOS JUNB ARHGAP18 RPL5P21 LOC102723409
GH06G129661 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.5 +47.2 47196 3.1 HDGF PKNOX1 ZFP64 ARID4B TCF12 ZNF766 ELK1 GATA2 MXD4 NCOA1 ARHGAP18 RPL5P21 LOC102723409
GH06G129707 1.6 FANTOM5 ENCODE dbSUPER 13.5 +0.9 895 3.8 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ARHGAP18 L3MBTL3 ENSG00000227678 LOC102723409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP18 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000323026 625 2401 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ARHGAP18 Gene

Chromosome:
6
Start:
129,576,132 bp from pter
End:
129,710,225 bp from pter
Size:
134,094 bases
Orientation:
Minus strand

Genomic View for ARHGAP18 Gene

Genes around ARHGAP18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP18 Gene

Proteins for ARHGAP18 Gene

  • Protein details for ARHGAP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N392-RHG18_HUMAN
    Recommended name:
    Rho GTPase-activating protein 18
    Protein Accession:
    Q8N392
    Secondary Accessions:
    • E1P575
    • Q58EZ3
    • Q6P679
    • Q6PJD7
    • Q96S64

    Protein attributes for ARHGAP18 Gene

    Size:
    663 amino acids
    Molecular mass:
    74977 Da
    Quaternary structure:
    • Interacts with MPHOSPH6.
    SequenceCaution:
    • Sequence=AAH17223.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH39611.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62417.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB61887.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP18 Gene

Post-translational modifications for ARHGAP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP18 Gene

No data available for DME Specific Peptides for ARHGAP18 Gene

Domains & Families for ARHGAP18 Gene

Gene Families for ARHGAP18 Gene

Protein Domains for ARHGAP18 Gene

Suggested Antigen Peptide Sequences for ARHGAP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP18: view

No data available for UniProtKB/Swiss-Prot for ARHGAP18 Gene

Function for ARHGAP18 Gene

Molecular function for ARHGAP18 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).

Gene Ontology (GO) - Molecular Function for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with ARHGAP18: view
genes like me logo Genes that share phenotypes with ARHGAP18: view

Animal Models for ARHGAP18 Gene

MGI Knock Outs for ARHGAP18:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP18 Gene

Localization for ARHGAP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP18 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP18 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IMP 21865595
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with ARHGAP18: view

Pathways & Interactions for ARHGAP18 Gene

genes like me logo Genes that share pathways with ARHGAP18: view

Pathways by source for ARHGAP18 Gene

3 Reactome pathways for ARHGAP18 Gene

Interacting Proteins for ARHGAP18 Gene

Selected Interacting proteins: Q8N392-RHG18_HUMAN for ARHGAP18 Gene via IID

Gene Ontology (GO) - Biological Process for ARHGAP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IMP 21865595
GO:0008360 regulation of cell shape IMP 21865595
GO:0030833 regulation of actin filament polymerization IMP 21865595
GO:0032956 regulation of actin cytoskeleton organization IMP 21865595
genes like me logo Genes that share ontologies with ARHGAP18: view

No data available for SIGNOR curated interactions for ARHGAP18 Gene

Drugs & Compounds for ARHGAP18 Gene

No Compound Related Data Available

Transcripts for ARHGAP18 Gene

Unigene Clusters for ARHGAP18 Gene

Rho GTPase activating protein 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP18 Gene

No ASD Table

Relevant External Links for ARHGAP18 Gene

GeneLoc Exon Structure for
ARHGAP18
ECgene alternative splicing isoforms for
ARHGAP18

Expression for ARHGAP18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP18 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP18 Gene

This gene is overexpressed in Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for ARHGAP18 Gene

This gene is overexpressed in Platelet (22.4), Peripheral blood mononuclear cells (16.4), Milk (6.8), and Nasal epithelium (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP18 Gene



Protein tissue co-expression partners for ARHGAP18 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP18 Gene:

ARHGAP18

SOURCE GeneReport for Unigene cluster for ARHGAP18 Gene:

Hs.486458

Evidence on tissue expression from TISSUES for ARHGAP18 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with ARHGAP18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP18 Gene

Orthologs for ARHGAP18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP18 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia ARHGAP18 34 35
  • 89.01 (n)
cow
(Bos Taurus)
Mammalia ARHGAP18 35 34
  • 88.8 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgap18 34
  • 84.94 (n)
mouse
(Mus musculus)
Mammalia Arhgap18 34 16 35
  • 84.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP18 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP18 34 35
  • 74.68 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP18 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734415 34
  • 66.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18124 34
zebrafish
(Danio rerio)
Actinopterygii LOC100004252 34
  • 60.11 (n)
ARHGAP18 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17082 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for ARHGAP18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP18 Gene

ENSEMBL:
Gene Tree for ARHGAP18 (if available)
TreeFam:
Gene Tree for ARHGAP18 (if available)

Paralogs for ARHGAP18 Gene

(4) SIMAP similar genes for ARHGAP18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP18: view

Variants for ARHGAP18 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000010026 -- 129,600,040(+) CATCA(C/T)TCTGT intron-variant
rs1000036464 -- 129,656,944(+) CCCCT(A/G)TATTT intron-variant
rs1000061052 -- 129,592,504(+) TAAAG(A/C)TTGAG intron-variant
rs1000084878 -- 129,593,041(+) CACCA(A/G)TAGGA intron-variant
rs1000091791 -- 129,592,925(+) TTCGA(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP18 Gene

Variant ID Type Subtype PubMed ID
esv1498345 CNV deletion 17803354
esv1575536 CNV deletion 17803354
esv1584644 CNV deletion 17803354
esv2639935 CNV insertion 19546169
esv2659313 CNV deletion 23128226
esv2732697 CNV deletion 23290073
esv3328429 CNV duplication 20981092
esv3610773 CNV loss 21293372
esv3610774 CNV loss 21293372
esv3610775 CNV gain 21293372
nsv1073587 CNV deletion 25765185
nsv1074014 CNV deletion 25765185
nsv1122137 CNV deletion 24896259
nsv1137149 CNV deletion 24896259
nsv1140694 CNV deletion 24896259
nsv522152 CNV gain 19592680
nsv524782 CNV loss 19592680
nsv604663 CNV gain 21841781
nsv830805 CNV gain 17160897
nsv950507 CNV duplication 24416366

Variation tolerance for ARHGAP18 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP18 Gene

Disorders for ARHGAP18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
penicilliosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP18

Genetic Association Database (GAD)
ARHGAP18
Human Genome Epidemiology (HuGE) Navigator
ARHGAP18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP18
genes like me logo Genes that share disorders with ARHGAP18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP18 Gene

Publications for ARHGAP18 Gene

  1. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. (PMID: 21865595) Maeda M. … Senga T. (Mol. Biol. Cell 2011) 3 4 64
  2. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PMID: 19065146) Potkin S.G. … Macciardi F. (Mol. Psychiatry 2009) 3 46 64
  4. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARHGAP18 Gene

Sources for ARHGAP18 Gene

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