ARHGAP18 Gene
protein-coding GIFtS: 52
GCID: GC06M129897
|
|
Rho GTPase activating protein 18
| |
Aliases
for ARHGAP18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 181 2 | | MacGAP1 2 3 | | BA307O14.21 | | Rho-Type GTPase-Activating Protein 182 3 | | SENEX2 | | Rho GTPase-Activating Protein 182 |
Export aliases for ARHGAP18 gene to outside databasesPrevious GC identifers: GC06M129832 GC06M129878 GC06M129939 GC06M127478 |
Summaries
for ARHGAP18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGAP18:
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin etal., 2009 (PubMed 19065146)).(supplied by OMIM, Apr 2010)
UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)
|
Genomic Views
for ARHGAP18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGAP18 gene promoter:
TBP RORalpha1 SRY S8 SREBP-1a FOXJ2 (long isoform) Chx10 FOXJ2 SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.33 Ensembl cytogenetic band: 6q22.33 HGNC cytogenetic band: 6q23.1ARHGAP18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M129897: view genomic region
(about GC identifiers)
Start:
|
129,897,277 bp from pter |
End:
|
130,031,370 bp from pter |
Size:
|
134,094 bases |
Orientation:
|
minus strand |
|
Proteins
for ARHGAP18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 18 Size: 663 amino acids; 74977 Da
Subunit: Interacts with MPHOSPH6
Sequence caution: Sequence=AAH17223.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH39611.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAH62417.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=BAB61887.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E1P575 Q58EZ3 Q6P679 Q6PJD7 Q96S64Alternative splicing: 2 isoforms: Q8N392-1 Q8N392-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARHGAP18: NX_Q8N392
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N392
ARHGAP18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_277050.2
ENSEMBL proteins: ENSP00000357131 ENSP00000275189 Reactome Protein details: Q8N392
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
ARHGAP18 for ontologies About GeneDecksing
ARHGAP18 Antibody Products:
Assay Products for ARHGAP18: |
Protein
Domains /
Families
for ARHGAP18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N392ProtoNet protein and cluster: Q8N392 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392Similarity: Contains 1 Rho-GAP domain |
Function
for ARHGAP18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RHG18_HUMAN, Q8N392Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- |
ARHGAP18 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ARHGAP18:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Arhgap18):
ARHGAP18 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGAP18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for ARHGAP18
ARHGAP18 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for ARHGAP18 (Q8N3923 ENSP000002751894) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
ARHGAP18 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGAP18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGAP18
Search CenterWatch for drugs/clinical trials and news about ARHGAP18 / RHG18
|
Transcripts
for ARHGAP18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGAP18 gene: NM_033515.2 Unigene Cluster for ARHGAP18: Rho GTPase activating protein 18 Hs.486458 [show with all ESTs]Unigene Representative Sequence: NM_0335154 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368149 ENST00000483367 ENST00000463225 ENST00000275189(uc003qbr.3 uc011ebw.2 uc021zfe.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGAP18 (NM_033515) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP18 |
Additional cDNA sequence: AB053293.1 AK002195.1 AK098594.1 AK307796.1 AL834511.1 AY643712.1 BC017223.2 BC039611.1 BC052295.1 BC062417.1 BC073143.1 BC101708.1 BC107416.1 BC111940.1 BC143531.1 5 DOTS entries: DT.107983 DT.121328540 DT.100035030 DT.121328539 DT.121328566 24/155 AceView cDNA sequences (see all 155): BC052295 BG031862 AA490588 BM980534 AA421756 AA357393 BQ430412 BQ029517 CA449202 BF431069 BM557178 BU752916 BM721946 BU664426 AI827394 BQ129374 AW612901 AA736655 AI783545 CB133859 AW157785 AA669517 AB053293 AL834511
GeneLoc Exon Structure
|
Expression
for ARHGAP18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCGCCAG
About this image
See ARHGAP18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP18
SOURCE GeneReport for Unigene cluster: Hs.486458
SABiosciences Custom PCR Arrays for ARHGAP18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18 |
Orthologs
for ARHGAP18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP18 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGAP181 |
Rho GTPase activating protein 18 |
74.68(n)
75.04(a) |
|
421706 XM_419743.3 XP_419743.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGAP186 |
-- |
69(a) |
1 ↔ 1 |
GL343315.1(683744-718408) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.181242 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.1(n) |
|
BG885983.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1000042521 |
rho GTPase-activating protein 18-like |
58.35(n)
57.03(a) |
|
100004252 XM_001343565.4 XP_001343601.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG170826 |
-- |
16(a) |
1 → many |
2R(631836-645548) |
ENSEMBL Gene Tree for ARHGAP18 (if available)
TreeFam Gene Tree for ARHGAP18 (if available) |
Paralogs
for ARHGAP18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGAP18 gene
- ARHGAP362 ARHGAP62 STARD132 ARHGAP402 ARHGAP11A2 DLC12 ARHGAP282 ARHGAP11B2
- STARD82
4 SIMAP similar genes for ARHGAP18 using alignment to 1 protein entry: RHG18_HUMAN:ARHGAP12 ARHGAP28 ARHGAP40 ARHGAP9
ARHGAP18 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGAP18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP18 (129897277 - 130031370 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ARHGAP18
1 CNV: 4507
4 Indels: 28093 28091 99706 28092 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP18 |
|
Disorders
/ Diseases
for ARHGAP18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP18 for disorders About GeneDecksing
OMIM gene information: 613351
OMIM disorders: --
4  diseases for ARHGAP18: About MalaCardsintellectual disability intrahepatic cholangiocarcinoma cholangiocarcinoma schizophrenia
1 disease from the University of Copenhagen DISEASES database for ARHGAP18:Intellectual disability Human Genome Epidemiology (HuGE) Navigator: ARHGAP18 (3 documents)
Export disorders for ARHGAP18 gene to outside databases
|
Publications
for ARHGAP18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP18 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ARHGAP18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
- ARHGAP18, a GTPase-activating protein for RhoA, contr ols cell shape, spreading, and motility. (PubMed id 21865595)1 Maeda M....Senga T. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Stress-induced premature senescence mediated by a nov el gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. (PubMed id 20664062)1 Coleman P.R....Gamble J.R. (2010)
- Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PubMed id 19065146)1 Potkin S.G....Macciardi F. (2009)
- Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1 Cronin S....Hardiman O. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for ARHGAP18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGAP18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGAP18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGAP18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGAP18 gene:
Search GeneIP for patents involving ARHGAP18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGAP18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP18 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP18 |
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