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Aliases for ARHGAP17 Gene

Aliases for ARHGAP17 Gene

  • Rho GTPase Activating Protein 17 2 3
  • RICH1 3 4 6
  • Rho-Type GTPase-Activating Protein 17 3 4
  • RICH-1 3 4
  • Neuron-Associated Developmentally Regulated Protein 3
  • RhoGAP Interacting With CIP4 Homologs Protein 1 4
  • RhoGAP Interacting With CIP4 Homologs 1 3
  • Rho GTPase-Activating Protein 17 3
  • MSTP038 3
  • MSTP066 3
  • MSTP110 3
  • MST066 3
  • MST110 3
  • NADRIN 3
  • PP4534 3
  • PP367 3
  • WBP15 3

External Ids for ARHGAP17 Gene

Summaries for ARHGAP17 Gene

Entrez Gene Summary for ARHGAP17 Gene

  • RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

GeneCards Summary for ARHGAP17 Gene

ARHGAP17 (Rho GTPase Activating Protein 17) is a Protein Coding gene. Diseases associated with ARHGAP17 include syringomyelia. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP17 Gene

  • Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP17 Gene

Genomics for ARHGAP17 Gene

Genomic Location for ARHGAP17 Gene

Start:
24,919,384 bp from pter
End:
25,015,666 bp from pter
Size:
96,283 bases
Orientation:
Minus strand

Genomic View for ARHGAP17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP17 Gene

Regulatory Elements for ARHGAP17 Gene

Proteins for ARHGAP17 Gene

  • Protein details for ARHGAP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68EM7-RHG17_HUMAN
    Recommended name:
    Rho GTPase-activating protein 17
    Protein Accession:
    Q68EM7
    Secondary Accessions:
    • A8K6M6
    • Q6ZUS4
    • Q7Z2F2
    • Q8NDG2
    • Q96KS2
    • Q96KS3
    • Q96SS8
    • Q9BVF6
    • Q9H8U5
    • Q9NW54

    Protein attributes for ARHGAP17 Gene

    Size:
    881 amino acids
    Molecular mass:
    95437 Da
    Quaternary structure:
    • Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.
    SequenceCaution:
    • Sequence=AAH01241.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13586.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13632.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP17 Gene

neXtProt entry for ARHGAP17 Gene

Proteomics data for ARHGAP17 Gene at MOPED

Post-translational modifications for ARHGAP17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP17 Gene

No data available for DME Specific Peptides for ARHGAP17 Gene

Domains for ARHGAP17 Gene

Gene Families for ARHGAP17 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP17 Gene

UniProtKB/Swiss-Prot:

RHG17_HUMAN
Domain:
  • The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.:
    • Q68EM7
  • Contains 1 BAR domain.:
    • Q68EM7
  • Contains 1 Rho-GAP domain.:
    • Q68EM7
genes like me logo Genes that share domains with ARHGAP17: view

Function for ARHGAP17 Gene

Molecular function for ARHGAP17 Gene

UniProtKB/Swiss-Prot Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Gene Ontology (GO) - Molecular Function for ARHGAP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 21481793
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ARHGAP17: view

miRNA for ARHGAP17 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP17 Gene

Localization for ARHGAP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP17 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP17 Gene COMPARTMENTS Subcellular localization image for ARHGAP17 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGAP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with ARHGAP17: view

Pathways for ARHGAP17 Gene

genes like me logo Genes that share pathways with ARHGAP17: view

Pathways by source for ARHGAP17 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ARHGAP17 Gene
2 BioSystems pathways for ARHGAP17 Gene
3 Reactome pathways for ARHGAP17 Gene

Gene Ontology (GO) - Biological Process for ARHGAP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP17: view

Transcripts for ARHGAP17 Gene

Unigene Clusters for ARHGAP17 Gene

Rho GTPase activating protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP17 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ·
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: -
SP9:
SP10: - -
SP11: - - -

ExUns: 17e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ARHGAP17 Gene

GeneLoc Exon Structure for
ARHGAP17
ECgene alternative splicing isoforms for
ARHGAP17

Expression for ARHGAP17 Gene

mRNA expression in normal human tissues for ARHGAP17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP17 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP17 Gene Hs.373793

mRNA Expression by UniProt/SwissProt for ARHGAP17 Gene

Q68EM7-RHG17_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in heart and placenta.
genes like me logo Genes that share expressions with ARHGAP17: view

Orthologs for ARHGAP17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP17 36
  • 99.24 (n)
  • 99.66 (a)
ARHGAP17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP17 36
  • 87.88 (n)
  • 90.7 (a)
ARHGAP17 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP17 36
  • 88.54 (n)
  • 90.81 (a)
ARHGAP17 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap17 36
  • 82.48 (n)
  • 86.35 (a)
Arhgap17 16
Arhgap17 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP17 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP17 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap17 36
  • 81.05 (n)
  • 84.55 (a)
chicken
(Gallus gallus)
Aves ARHGAP17 36
  • 73.58 (n)
  • 73.65 (a)
ARHGAP17 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP17 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap17 36
  • 72.1 (n)
  • 74.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ARHGAP17 (2 of 3) 37
  • 61 (a)
OneToMany
arhgap17a 37
  • 57 (a)
OneToMany
arhgap17b 36
  • 67.55 (n)
  • 68.43 (a)
arhgap17b 37
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009727 36
  • 46 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP92B 36
  • 44.56 (n)
  • 33.26 (a)
RhoGAP92B 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y34B4A.8 37
  • 25 (a)
OneToMany
Species with no ortholog for ARHGAP17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP17 Gene

ENSEMBL:
Gene Tree for ARHGAP17 (if available)
TreeFam:
Gene Tree for ARHGAP17 (if available)

Paralogs for ARHGAP17 Gene

Selected SIMAP similar genes for ARHGAP17 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ARHGAP17 Gene

genes like me logo Genes that share paralogs with ARHGAP17: view

Variants for ARHGAP17 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs719140 -- 24,918,999(+) AAAGC(A/C)CCAGC downstream-variant-500B
rs748221 -- 24,971,656(-) TTTTA(G/T)AATGA intron-variant
rs873305 -- 24,969,699(+) GAAGC(A/C)CAAAC intron-variant
rs891122 -- 24,959,412(+) ACAGG(C/T)ACTCC intron-variant
rs891842 -- 25,010,990(+) GCCTC(A/G)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP17 Gene

Variant ID Type Subtype PubMed ID
nsv833175 CNV Loss 17160897
nsv509607 CNV Insertion 20534489
dgv840e1 CNV Complex 17122850
esv273352 CNV Insertion 20981092
nsv905681 CNV Loss 21882294

Relevant External Links for ARHGAP17 Gene

HapMap Linkage Disequilibrium report
ARHGAP17

Disorders for ARHGAP17 Gene

(1) MalaCards Diseases for ARHGAP17 Gene

Search for ARHGAP17 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARHGAP17 Gene

Relevant External Links for ARHGAP17

Genetic Association Database (GAD)
ARHGAP17
Human Genome Epidemiology (HuGE) Navigator
ARHGAP17
genes like me logo Genes that share disorders with ARHGAP17: view

No data available for UniProtKB/Swiss-Prot for ARHGAP17 Gene

Publications for ARHGAP17 Gene

  1. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. (PMID: 10967100) Harada A. … Umeda M. (J. Biol. Chem. 2000) 2 3 23
  2. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. (PMID: 11285285) Reczek D. … Bretscher A. (J. Cell Biol. 2001) 3 4 23
  3. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. (PMID: 11431473) Richnau N. … Aspenstroem P. (J. Biol. Chem. 2001) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARHGAP17 Gene

Sources for ARHGAP17 Gene

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