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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP17 Gene

protein-coding   GIFtS: 56
GCID: GC16M024931

Rho GTPase activating protein 17
 Explore 4 diseases affiliated with
ARHGAP17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGAP17    

Aliases
for ARHGAP17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho GTPase Activating Protein 171 2     MST1102
RICH11 2 3 5     MSTP0382
NADRIN1 2     MSTP0662
WBP151 2     MSTP1102
Rho-Type GTPase-Activating Protein 172 3     PP3672
RhoGAP Interacting With CIP4 Homologs Protein 12 3     PP45342
RICH-12 3     RICH1B2
FLJ103081     Neuron-Associated Developmentally Regulated Protein2
FLJ132191     Rho GTPase-Activating Protein 172
MST0662     RhoGAP Interacting With CIP4 Homologs 12

External Ids:    HGNC: 182391   Entrez Gene: 551142   Ensembl: ENSG000001407507   OMIM: 6082935   UniProtKB: Q68EM73   

Export aliases for ARHGAP17 gene to outside databases

Previous GC identifers: GC16M024898 GC16M024838 GC16M023024


Summaries
for ARHGAP17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGAP17:
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as
RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: RHG17_HUMAN, Q68EM7
Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of
CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator
for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating
the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins
are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of
exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the
cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1




Genomic Views
for ARHGAP17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP17 gene promoter:
         c-Fos   TBP   AP-1   AML1a   Lmo2   E47   Arnt   SEF-1 (1)   c-Jun   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP17 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p12.2-p12.1

ARHGAP17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP17 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M024931:  view genomic region     (about GC identifiers)

Start:
 24,930,706 bp from pter      End:
 25,026,987 bp from pter
Size:
 96,282 bases      Orientation:
 minus strand

Proteins
for ARHGAP17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHG17_HUMAN, Q68EM7 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 17  
Size: 881 amino acids; 95437 Da
Subunit: Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates
with membranes and concentrates at sites of cell-cell contact
Sequence caution: Sequence=AAH01241.1; Type=Erroneous initiation; Sequence=AAQ13586.1; Type=Erroneous initiation;
Sequence=AAQ13632.1; Type=Erroneous initiation;
Secondary accessions: A8K6M6 Q6ZUS4 Q7Z2F2 Q8NDG2 Q96KS2 Q96KS3 Q96SS8 Q9BVF6 Q9H8U5 Q9NW54
Alternative splicing: 7 isoforms:  Q68EM7-1   Q68EM7-2   Q68EM7-3   Q68EM7-4   Q68EM7-5   Q68EM7-6   Q68EM7-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGAP17: NX_Q68EM7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68EM7

    • ARHGAP17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006635.1  NP_060524.4  

    ENSEMBL proteins: 
     ENSP00000289968   ENSP00000303130   ENSP00000461639   ENSP00000460985   ENSP00000460600  
     ENSP00000406701   ENSP00000459074   ENSP00000461411   ENSP00000461426   ENSP00000406950  
    Reactome Protein details: Q68EM7
    Human Recombinant Protein Products: 
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    Novus Biologicals ARHGAP17 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARHGAP17

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005626insoluble fraction ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005923tight junction IEA--
    GO:0016020membrane IEA--


    ARHGAP17 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARHGAP17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGAP17 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR004148 BAR_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q68EM7

    ProtoNet protein and cluster: Q68EM7

    1 Blocks protein family: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHG17_HUMAN, Q68EM7
    Domain: The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to
    tight junctions
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 Rho-GAP domain


    Function
    for ARHGAP17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHG17_HUMAN, Q68EM7
    Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of
    CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator
    for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating
    the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins
    are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of
    exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the
    cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1

    miRNA
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    hsa-miR-607 hsa-miR-562 hsa-miR-3942-5p hsa-miR-1271 hsa-miR-1297 hsa-miR-1184 hsa-miR-4274 hsa-miR-3908
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--


    ARHGAP17 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ARHGAP17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling Regulation of RAC1 activity
    		G-protein signaling Regulation of CDC42 activity0.25
    		G-protein signaling_Regulation of CDC42 activity0.25
    2Cell death signalling via NRAGE, NRIF and NADE
    		Rho GTPase cycle0.25
    		Signaling by Rho GTPases0.25
    3Regulation of CDC42 activity
    		Regulation of CDC42 activity1.00
    4Regulation of RAC1 activity
    		Regulation of RAC1 activity1.00
    5Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ARHGAP17
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for ARHGAP17
        G-protein signaling Regulation of CDC42 activity

    2 BioSystems Pathways for ARHGAP17 
        Regulation of CDC42 activity
    Regulation of RAC1 activity

    3        Reactome Pathways for ARHGAP17
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP17 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/37 Interacting proteins for ARHGAP17 (Q68EM71, 2, 3 ENSP000002899684) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-73246 I2D: score=1 STRING: ENSP00000262613
    AMOTQ4VCS51, 3, ENSP000003610274EBI-2398436,EBI-2511319 I2D: score=2 STRING: ENSP00000361027
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0017156calcium ion-dependent exocytosis ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--


    ARHGAP17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGAP17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP17
    Search CenterWatch for drugs/clinical trials and news about ARHGAP17 / RHG17 

    Transcripts
    for ARHGAP17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGAP17 gene (2 alternative transcripts): 
    NM_001006634.1  NM_018054.4  

    Unigene Cluster for ARHGAP17:

    Rho GTPase activating protein 17
    Hs.373793  [show with all ESTs]
    Unigene Representative Sequence: NM_001006634
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000289968(uc002dnb.3 uc002dnc.3 uc010vcf.2) ENST00000573703(uc002dnd.1)
    ENST00000570320(uc002dmy.3) ENST00000303665 ENST00000571843 ENST00000575283(uc002dmz.3)
    ENST00000573765 ENST00000571406 ENST00000572314(uc002dna.3) ENST00000575412
    ENST00000570841 ENST00000575656 ENST00000576387 ENST00000575975 ENST00000455311
    ENST00000571480 ENST00000573625 ENST00000571575

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    hsa-miR-607 hsa-miR-562 hsa-miR-3942-5p hsa-miR-1271 hsa-miR-1297 hsa-miR-1184 hsa-miR-4274 hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP17 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF113218.1 AF163257.1 AF173885.1 AF258560.1 AF258580.1 AJ306731.1 AJ306732.1 AK001170.1 
    AK023281.1 AK027567.1 AK094886.1 AK291691.1 AK301055.1 AK301500.1 AL833975.1 BC001241.1 
    BC080195.1 

    22 DOTS entries:

    DT.100815965  DT.216134  DT.100030688  DT.100815967  DT.92442667  DT.100815962  DT.97864243  DT.40209242 
    DT.95107057  DT.120679517  DT.97864242  DT.100815963  DT.99987265  DT.120679528  DT.120679539  DT.40242910 
    DT.70102564  DT.91773827  DT.92442668  DT.97810108  DT.40259593  DT.95074048 

    24/320 AceView cDNA sequences (see all 320):

    AI306547 BF224229 BG005357 AL532472 AI474389 BC001241 AI559676 AI085310 
    AW516075 BQ212512 AA564824 CK822422 BF109014 BQ422029 BP345238 BM504871 
    AW020350 BU160409 BM800974 AI718362 AL708236 BQ889666 BF724895 BC080195 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP17 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ·
    SP1:              -                                                                                                                                             
    SP2:                                                                                      -     -                                                               
    SP3:                                                                                      -                                                                     
    SP4:                                                                                      -     -                                                               
    SP5:                                      -                                                                                                                     

    ExUns: 17e
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ARHGAP17

    Expression
    for ARHGAP17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTAATTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ARHGAP17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP17

    SOURCE GeneReport for Unigene cluster: Hs.373793

    UniProtKB/Swiss-Prot: RHG17_HUMAN, Q68EM7
    Tissue specificity: Ubiquitously expressed. Expressed at higher level in heart and placenta

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    In Situ
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    Orthologs
    for ARHGAP17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP17 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARHGAP171 Rho GTPase activating protein 17 73.58(n)
    73.65(a)    		   416564  XM_414864.2  XP_414864.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGAP176
    SRGAP26
    (see all 3)    		 --
    		 74(a)
    13(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 GL343986.1(60112-101525)
    AAWZ02038242(5370-9744)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003308691 rho GTPase-activating protein 17-like 67.62(n)
    68.43(a)    		   100330869  XM_002661140.2  XP_002661186.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RhoGAP92B1 CG4755-PA 42.23(n)
    30.38(a)    		   42371  NM_142587.1  NP_650844.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y34B4A.81 Protein Y34B4A.8 41.7(n)
    28.38(a)    		   180799  NM_076493.3  NP_508894.2 


    ENSEMBL Gene Tree for ARHGAP17 (if available)
    TreeFam Gene Tree for ARHGAP17 (if available) 

    Paralogs
    for ARHGAP17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP17 gene
    SRGAP12  ARHGAP52  ARHGAP242  ARHGAP222  ARHGAP352  SRGAP32  ARHGAP442  SH3BP12  
    ARHGAP42  SRGAP22  ARHGAP252  
    4 SIMAP similar genes for ARHGAP17 using alignment to 8 protein entries:     RHG17_HUMAN (see all proteins):
    ARHGAP44    ARHGAP12    SH3BP1    DKFZp434B034

    ARHGAP17 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARHGAP17
    PGOHUM00000247784 PGOHUM00000248153


    Genomic Variants
    for ARHGAP17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1763 NCBI SNPs in ARHGAP17 are shown (see all 1763)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1448774481,2
    		--24930284(+) GAGACC/GGGATA 2 -- ds50010--------
    rs610746581,2
    		C,F,--24930297(+) TTTCAC/TGCCTT 2 -- ds50014Minor allele frequency- T:0.24WA CSA 123
    rs1813536971,2
    		--24930382(+) AACCCA/GGTGGG 2 -- ds50010--------
    rs1402726551,2
    		--24930387(+) GGTGGC/GGCTGA 2 -- ds50010--------
    rs1860015541,2
    		--24930417(+) GGGAGA/TCTGAG 2 -- ds50010--------
    rs1883081881,2
    		--24930533(+) CCTGGC/TGGCCT 2 -- ds50010--------
    rs285404341,2
    		C,F,H,--24930548(+) CACTGT/CTGCGA 2 -- ds500121Minor allele frequency- C:0.33NS EA NA WA CSA 2226
    rs1477946321,2
    		--24930647(+) GCAACA/GCACAC 2 -- ds50010--------
    rs1452815151,2
    		C,--24930662(+) TCATG-/CACACAC 2 -- ds50010--------
    rs1413830331,2
    		--24930795(+) TTACAC/TTGTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGAP17 (24930706 - 25026987 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARHGAP17
         1 CNV: 3997

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    Disorders / Diseases
    for ARHGAP17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGAP17 for disorders           About GeneDecksing

    OMIM gene information: 608293    OMIM disorders: --

    4 diseases for ARHGAP17:    About MalaCards
    neuronitis    syringomyelia    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ARHGAP17:
    Syringomyelia
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP17 (1 document)

    Export disorders for ARHGAP17 gene to outside databases

    Publications
    for ARHGAP17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP17 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ARHGAP17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. (PubMed id 11431473)1, 2, 3 Richnau N. and Aspenstroem P. (2001)
    2. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. (PubMed id 10967100)1, 3, 9 Harada A....Umeda M. (2000)
    3. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. (PubMed id 11285285)1, 2, 9 Reczek D. and Bretscher A. (2001)
    4. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for ARHGAP17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARHGAP17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55114 HGNC: 18239 AceView: ARHGAP17 Ensembl:ENSG00000140750 euGenes: HUgn55114
    ECgene: ARHGAP17 H-InvDB: ARHGAP17

    Other Databases showing ARHGAP17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARHGAP17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP17 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARHGAP17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGAP17 gene:
    Search GeneIP for patents involving ARHGAP17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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