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Aliases for ARHGAP15 Gene

Aliases for ARHGAP15 Gene

  • Rho GTPase Activating Protein 15 2 3
  • Rho-Type GTPase-Activating Protein 15 3 4
  • BM046 3 6
  • Rho GTPase-Activating Protein 15 3
  • ArhGAP15 4

External Ids for ARHGAP15 Gene

Summaries for ARHGAP15 Gene

Entrez Gene Summary for ARHGAP15 Gene

  • RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP15 Gene

ARHGAP15 (Rho GTPase Activating Protein 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for ARHGAP15 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP15 Gene

Genomics for ARHGAP15 Gene

Genomic Location for ARHGAP15 Gene

143,091,362 bp from pter
143,768,352 bp from pter
676,991 bases
Plus strand

Genomic View for ARHGAP15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP15 Gene

Regulatory Elements for ARHGAP15 Gene

Proteins for ARHGAP15 Gene

  • Protein details for ARHGAP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 15
    Protein Accession:
    Secondary Accessions:
    • Q53R36
    • Q53RD7
    • Q53RT6
    • Q53SX9
    • Q584N9
    • Q6PJE6
    • Q86WP1
    • Q8IXX1
    • Q9NRL8
    • Q9NZ77
    • Q9NZ91

    Protein attributes for ARHGAP15 Gene

    475 amino acids
    Molecular mass:
    54544 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316, 323, 332; Evidence={ECO:0000305}; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF87324.1; Type=Frameshift; Positions=202, 233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP15 Gene

neXtProt entry for ARHGAP15 Gene

Proteomics data for ARHGAP15 Gene at MOPED

Post-translational modifications for ARHGAP15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys206 and Lys327

Other Protein References for ARHGAP15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP15 Gene

Domains for ARHGAP15 Gene

Gene Families for ARHGAP15 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP15 Gene


  • The PH domain is required for localization to the membrane.:
    • Q53QZ3
  • Contains 1 PH domain.:
    • Q53QZ3
  • Contains 1 Rho-GAP domain.:
    • Q53QZ3
genes like me logo Genes that share domains with ARHGAP15: view

Function for ARHGAP15 Gene

Molecular function for ARHGAP15 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

Gene Ontology (GO) - Molecular Function for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 12650940
genes like me logo Genes that share ontologies with ARHGAP15: view

Phenotypes for ARHGAP15 Gene

genes like me logo Genes that share phenotypes with ARHGAP15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP15 Gene

Localization for ARHGAP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP15 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for ARHGAP15 Gene COMPARTMENTS Subcellular localization image for ARHGAP15 gene
Compartment Confidence
cytosol 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP15: view

Pathways for ARHGAP15 Gene

genes like me logo Genes that share pathways with ARHGAP15: view

Pathways by source for ARHGAP15 Gene

3 Reactome pathways for ARHGAP15 Gene

Gene Ontology (GO) - Biological Process for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape IDA 12650940
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP15: view

Transcripts for ARHGAP15 Gene

Unigene Clusters for ARHGAP15 Gene

Rho GTPase activating protein 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -

Relevant External Links for ARHGAP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP15 Gene

mRNA expression in normal human tissues for ARHGAP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP15 Gene

This gene is overexpressed in Whole Blood (21.8) and Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP15 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP15 Gene Hs.171011

mRNA Expression by UniProt/SwissProt for ARHGAP15 Gene

Tissue specificity: Expressed in lung, liver and lymphoid cells.
genes like me logo Genes that share expressions with ARHGAP15: view

Orthologs for ARHGAP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP15 36
  • 99.72 (n)
  • 99.58 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ARHGAP15 36
  • 92.98 (n)
  • 94.47 (a)
  • 94 (a)
(Canis familiaris)
Mammalia ARHGAP15 36
  • 94.18 (n)
  • 95.16 (a)
  • 95 (a)
(Mus musculus)
Mammalia Arhgap15 36
  • 88.37 (n)
  • 86.89 (a)
Arhgap15 16
Arhgap15 37
  • 85 (a)
(Monodelphis domestica)
Mammalia ARHGAP15 37
  • 91 (a)
(Rattus norvegicus)
Mammalia Arhgap15 36
  • 86.75 (n)
  • 84.14 (a)
(Gallus gallus)
Aves ARHGAP15 36
  • 80.48 (n)
  • 82.03 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia ARHGAP15 37
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485536 36
  • 68.08 (n)
  • 64.68 (a)
(Danio rerio)
Actinopterygii arhgap15 36
  • 64.27 (n)
  • 60.45 (a)
arhgap15 37
  • 59 (a)
(Caenorhabditis elegans)
Secernentea tag-325 36
  • 46.13 (n)
  • 34.17 (a)
tag-325 37
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for ARHGAP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP15 Gene

Gene Tree for ARHGAP15 (if available)
Gene Tree for ARHGAP15 (if available)

Paralogs for ARHGAP15 Gene

Selected SIMAP similar genes for ARHGAP15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP15: view

Variants for ARHGAP15 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs173310 -- 143,188,926(-) aggca(C/T)agggg intron-variant
rs181371 -- 143,131,557(-) CTATG(A/G)GACTC intron-variant
rs187133 -- 143,162,817(-) TACAA(C/T)TGTAT intron-variant
rs187135 -- 143,135,714(-) agtat(C/T)ccaga intron-variant
rs189559 -- 143,162,860(-) GTTAA(C/T)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP15 Gene

Variant ID Type Subtype PubMed ID
esv2720910 CNV Deletion 23290073
esv2720911 CNV Deletion 23290073
esv2667585 CNV Deletion 23128226
esv2720912 CNV Deletion 23290073
esv2720913 CNV Deletion 23290073
nsv515703 CNV Loss 19592680
esv2672231 CNV Deletion 23128226
nsv523591 CNV Loss 19592680
nsv524638 CNV Loss 19592680
nsv2955 CNV Insertion 18451855
esv994769 CNV Insertion 20482838
nsv821742 CNV Gain 20364138
esv267613 CNV Insertion 20981092
nsv519096 CNV Loss 19592680
esv26609 CNV Gain 19812545
nsv213976 CNV Loss 16902084
nsv2956 CNV Insertion 18451855
esv273694 CNV Insertion 20981092
nsv821744 CNV Gain 20364138
esv2720914 CNV Deletion 23290073
nsv459707 CNV Loss 19166990
esv2670420 CNV Deletion 23128226
nsv821745 CNV Loss 20364138

Relevant External Links for ARHGAP15 Gene

HapMap Linkage Disequilibrium report

Disorders for ARHGAP15 Gene

Relevant External Links for ARHGAP15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGAP15: view

No data available for UniProtKB/Swiss-Prot for ARHGAP15 Gene

Publications for ARHGAP15 Gene

  1. ArhGAP15, a novel human RacGAP protein with GTPase binding property. (PMID: 12650940) Seoh M.L. … Leung T. (FEBS Lett. 2003) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 49

Products for ARHGAP15 Gene

Sources for ARHGAP15 Gene

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