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ARHGAP15 Gene

protein-coding   GIFtS: 53
GCID: GC02P143848

Rho GTPase Activating Protein 15

  Search for ARHGAP15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 151 2
Rho-Type GTPase-Activating Protein 152 3
BM0462 5
Rho GTPase-Activating Protein 152
ArhGAP153

External Ids:    HGNC: 210301   Entrez Gene: 558432   Ensembl: ENSG000000758847   OMIM: 6105785   UniProtKB: Q53QZ33   

Export aliases for ARHGAP15 gene to outside databases

Previous GC identifers: GC02P142204 GC02P143909 GC02P144097 GC02P143720 GC02P143603 GC02P143565 GC02P135878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP15 Gene:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO
GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 (PubMed 12650940)).(supplied by OMIM, Mar
2008)

GeneCards Summary for ARHGAP15 Gene:
ARHGAP15 (Rho GTPase activating protein 15) is a protein-coding gene. GO annotations related to this gene include Rac GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has
activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP15 gene promoter:
         LHX3b/Lhx3b   AML1a   FOXO3   CUTL1   Evi-1   FOXO3b   STAT3   LHX3a/Lhx3a   IRF-7A   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP15 promoter sequence
   Search Chromatin IP Primers for ARHGAP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.2-q22.3   Ensembl cytogenetic band:  2q22.2   HGNC cytogenetic band: 2q22.2-q22.3

ARHGAP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P143848:  view genomic region     (about GC identifiers)

Start:
143,848,931 bp from pter      End:
144,525,921 bp from pter
Size:
676,991 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 15  
Size: 475 amino acids; 54544 Da
Sequence caution: Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316,
323, 332; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Sequence=AAF87324.1; Type=Frameshift;
Positions=202, 233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418;
1 PDB 3D structure from and Proteopedia for ARHGAP15:
3BYI (3D)    
Secondary accessions: Q53R36 Q53RD7 Q53RT6 Q53SX9 Q584N9 Q6PJE6 Q86WP1 Q8IXX1 Q9NRL8 Q9NZ77
Q9NZ91

Explore the universe of human proteins at neXtProt for ARHGAP15: NX_Q53QZ3

Explore proteomics data for ARHGAP15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys206, Lys327
  • Modification sites at PhosphoSitePlus

  • See ARHGAP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060930.3  
    ENSEMBL proteins: 
     ENSP00000386560   ENSP00000295095   ENSP00000390310  
    Reactome Protein details: Q53QZ3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR015767 Rho_GTPase_activating
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q53QZ3

    ProtoNet protein and cluster: Q53QZ3

    UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
    Domain: The PH domain is required for localization to the membrane
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG15_HUMAN, Q53QZ3
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has
    activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030675Rac GTPase activator activity IDA12650940
         
    Find genes that share ontologies with ARHGAP15           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap15):
     hematopoietic system  immune system 

    Find genes that share phenotypes with ARHGAP15           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGAP15
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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP15 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG15_HUMAN, Q53QZ3: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with ARHGAP15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP15 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with ARHGAP15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARHGAP15
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP15
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP15 (Q53QZ32, 3 ENSP000002950954) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630002, 3, ENSP000003484614MINT-19382 MINT-19392 I2D: score=3 STRING: ENSP00000348461
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    CD93Q9NPY33, ENSP000002460064I2D: score=2 STRING: ENSP00000246006
    SNCAP378403, ENSP000003383454I2D: score=1 STRING: ENSP00000338345
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008360regulation of cell shape IDA12650940
    GO:0032855positive regulation of Rac GTPase activity IDA12650940
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP15 (RHG15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP15 gene: 
    NM_018460.3  

    Unigene Cluster for ARHGAP15:

    Rho GTPase activating protein 15
    Hs.171011  [show with all ESTs]
    Unigene Representative Sequence: NM_018460
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409869 ENST00000295095(uc002tvm.4 uc002tvn.3) ENST00000552641(uc010zbl.1)
    ENST00000460776 ENST00000474474 ENST00000469117 ENST00000548800 ENST00000548242
    ENST00000548929 ENST00000552289 ENST00000549436 ENST00000419455 ENST00000473426
    ENST00000549060
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ARHGAP15:
    hsa-miR-33a* hsa-miR-576-3p hsa-miR-205* hsa-miR-3662 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP15
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    Addgene plasmids for ARHGAP15 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGAP15
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP15
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP15

    Additional mRNA sequence: 

    AF212222.1 AF217507.1 AF217522.1 AK226014.1 AK303490.1 AK308219.1 AY219338.1 BC016701.2 
    BC038976.1 

    9 DOTS entries:

    DT.316954  DT.99977039  DT.91861911  DT.92430523  DT.65285433  DT.95268221  DT.120942634  DT.92430527 
    DT.92430528 

    Selected AceView cDNA sequences (see all 157):

    BX094274 AA644294 BF593750 AA233664 N59846 AL543868 BX340749 N49790 
    AA001973 AA233550 AI915381 AA723688 AI718247 R44856 BM470092 AI718088 
    BI765032 N80843 BI518769 BP359003 AI400546 BG192457 AA731538 AW468004 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP15    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                    -     -     -                     
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for ARHGAP15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGTGAGT
    ARHGAP15 Expression
    About this image


    ARHGAP15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    ARHGAP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171011

    UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
    Tissue specificity: Expressed in lung, liver and lymphoid cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP15 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap151 , 5 Rho GTPase activating protein 151, 5 88.37(n)1
    86.89(a)1
      2 (26.13 cM)5
    761171  NM_153820.31  NP_722542.21 
     437488245 
    chicken
    (Gallus gallus)
    Aves ARHGAP151 Rho GTPase activating protein 15 80.48(n)
    82.03(a)
      424303  NM_001008476.1  NP_001008476.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP156
    Rho GTPase activating protein 15
    75(a)
    1 ↔ 1
    1(101370540-101863805)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004855361 rho GTPase-activating protein 15-like 68.08(n)
    64.68(a)
      100485536  XM_002937355.2  XP_002937401.2 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap151 Rho GTPase activating protein 15 64.27(n)
    60.45(a)
      100003547  NM_001128555.1  NP_001122027.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3251 tag-325 46.13(n)
    34.17(a)
      175636  NM_065588.5  NP_497989.1 


    ENSEMBL Gene Tree for ARHGAP15 (if available)
    TreeFam Gene Tree for ARHGAP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP15 gene
    ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP232  ARHGAP92  CHN12  ARHGAP262  
    ARHGAP122  OPHN12  ARHGAP422  
    6 SIMAP similar genes for ARHGAP15 using alignment to 3 protein entries:     RHG15_HUMAN (see all proteins):
    ARHGAP12    ARHGAP9    ARHGAP27    CHN1    BCR/ABL fusion    ARHGAP21

    Find genes that share paralogs with ARHGAP15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP15 (see all 11925)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677508311,2
    C--143402880(+) TGTGT-/GT    
       
    /GTGT
    ATAAT
    1 -- int12NA 4
    rs40083411,2
    C--143565466(+) CACAC-/AC    
       
    /ACAC
    TACAC
    1 -- int12NA 4
    rs581530001,2
    C--143630657(+) ATCTC-/AAAAAAAA 1 -- int10--------
    rs1454413681,2
    C--143727997(+) TAGAT-/AAAG  
            
    AAGAT
    1 -- int10--------
    rs130046511,2
    C--143884910(+) TATTGG/TTATTT 1 -- us2k1 tfbs31Minor allele frequency- T:0.50NA 2
    rs1830415181,2
    --143884932(+) TAGTCA/GGATGC 1 -- us2k10--------
    rs1873682301,2
    --143884975(+) TGGCCA/GGGAGT 1 -- us2k10--------
    rs714232611,2
    C,F--143885045(+) CAAGAG/CATAGA 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1841517351,2
    --143885086(+) TCTCTA/GCTAAA 1 -- us2k10--------
    rs779315811,2
    C--143885131(+) CTGTAA/GTCTCA 1 -- us2k12Minor allele frequency- G:0.06WA NA 122

    HapMap Linkage Disequilibrium report for ARHGAP15 (143848931 - 144098931 bp, first 250kb of ARHGAP15)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGAP15 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720911CNV Deletion23290073
    esv2720910CNV Deletion23290073
    esv2672231CNV Deletion23128226
    esv2670420CNV Deletion23128226
    esv2667585CNV Deletion23128226
    esv2720913CNV Deletion23290073
    esv2720914CNV Deletion23290073
    esv2720912CNV Deletion23290073
    esv267613CNV Insertion20981092
    esv994769CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610578    OMIM disorders: --


    Find genes that share disorders with ARHGAP15           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP15
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP15 (2 documents)

    Export disorders for ARHGAP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP15 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ARHGAP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ArhGAP15, a novel human RacGAP protein with GTPase binding property. (PubMed id 12650940)1, 2, 3 Seoh M.L.... Leung T. (FEBS Lett. 2003)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. (PubMed id 23760270)1 Radu M....Chernoff J. (J. Biol. Chem. 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1. (PubMed id 21297076)1 Leikauf G.D....Prows D.R. (Am. J. Respir. Crit. Care Med. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55843 HGNC: 21030 AceView: ARHGAP15 Ensembl:ENSG00000075884 euGenes: HUgn55843
    ECgene: ARHGAP15 H-InvDB: ARHGAP15

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP15 gene:
    Search GeneIP for patents involving ARHGAP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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