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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP15 Gene

protein-coding   GIFtS: 51
GCID: GC02P143848

Rho GTPase activating protein 15
 Explore 2 diseases affiliated with
ARHGAP15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGAP15    

Aliases
for ARHGAP15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho GTPase Activating Protein 151 2
BM0461 2
Rho-Type GTPase-Activating Protein 152 3
Rho GTPase-Activating Protein 152
ArhGAP153

External Ids:    HGNC: 210301   Entrez Gene: 558432   Ensembl: ENSG000000758847   OMIM: 6105785   UniProtKB: Q53QZ33   

Export aliases for ARHGAP15 gene to outside databases

Previous GC identifers: GC02P142204 GC02P143909 GC02P144097 GC02P143720 GC02P143603 GC02P143565 GC02P135878


Summaries
for ARHGAP15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGAP15:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO
GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 (PubMed 12650940)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity
toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction




Genomic Views
for ARHGAP15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP15 gene promoter:
         LHX3b/Lhx3b   AML1a   FOXO3   CUTL1   Evi-1   FOXO3b   STAT3   LHX3a/Lhx3a   IRF-7A   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP15 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.2-q22.3   Ensembl cytogenetic band:  2q22.2   HGNC cytogenetic band: 2q22.2-q22.3

ARHGAP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P143848:  view genomic region     (about GC identifiers)

Start:
 143,848,931 bp from pter      End:
 144,525,921 bp from pter
Size:
 676,991 bases      Orientation:
 plus strand

Proteins
for ARHGAP15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 15  
Size: 475 amino acids; 54544 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316, 323,
332; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Sequence=AAF87324.1; Type=Frameshift; Positions=202,
233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418;
1 PDB 3D structure from and Proteopedia for ARHGAP15:
3BYI (3D)    
Secondary accessions: Q53R36 Q53RD7 Q53RT6 Q53SX9 Q584N9 Q6PJE6 Q86WP1 Q8IXX1 Q9NRL8 Q9NZ77 Q9NZ91

Explore the universe of human proteins at neXtProt for ARHGAP15: NX_Q53QZ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53QZ3

    • ARHGAP15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060930.3  
    ENSEMBL proteins: 
     ENSP00000386560   ENSP00000295095   ENSP00000390310  
    Reactome Protein details: Q53QZ3
    Human Recombinant Protein Products: 
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    Novus Biologicals ARHGAP15 Protein
    Novus Biologicals ARHGAP15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARHGAP15

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--


    ARHGAP15 for ontologies           About GeneDecksing



    ARHGAP15 Antibody Products: 
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    Uscn ELISAs and CLIAs for ARHGAP15

    Protein Domains /
    Families
    for ARHGAP15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGAP15 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR015767 Rho_GTPase_activating
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q53QZ3

    ProtoNet protein and cluster: Q53QZ3

    UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
    Domain: The PH domain is required for localization to the membrane
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    Function
    for ARHGAP15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity
    toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARHGAP15
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP15
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP15:
    hsa-miR-33a* hsa-miR-576-3p hsa-miR-205* hsa-miR-3662 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP15 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP15 (see all 7)
    OriGene shRNA RFP: ARHGAP15
    OriGene siRNA: ARHGAP15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP15

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARHGAP15

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP15 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ARHGAP15

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP15

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--
    GO:0030675Rac GTPase activator activity IDA12650940


    ARHGAP15 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arhgap15):
     hematopoietic system  immune system 

    ARHGAP15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARHGAP15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    2Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ARHGAP15
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for ARHGAP15 (Q53QZ32, 3 ENSP000002950954) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630002, 3, ENSP000003484614MINT-19382 MINT-19392 I2D: score=3 STRING: ENSP00000348461
    CD93Q9NPY33, ENSP000002460064I2D: score=2 STRING: ENSP00000246006
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    SNCAP378403, ENSP000003383454I2D: score=1 STRING: ENSP00000338345
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008360regulation of cell shape IDA12650940
    GO:0032855positive regulation of Rac GTPase activity IDA12650940
    GO:0051056regulation of small GTPase mediated signal transduction TAS--


    ARHGAP15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGAP15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP15
    Search CenterWatch for drugs/clinical trials and news about ARHGAP15 / RHG15 

    Transcripts
    for ARHGAP15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGAP15 gene: 
    NM_018460.3  

    Unigene Cluster for ARHGAP15:

    Rho GTPase activating protein 15
    Hs.171011  [show with all ESTs]
    Unigene Representative Sequence: NM_018460
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409869 ENST00000295095(uc002tvm.4 uc002tvn.3) ENST00000552641(uc010zbl.1)
    ENST00000460776 ENST00000474474 ENST00000469117 ENST00000548800 ENST00000548242
    ENST00000548929 ENST00000552289 ENST00000549436 ENST00000419455 ENST00000473426
    ENST00000549060

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP15
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP15:
    hsa-miR-33a* hsa-miR-576-3p hsa-miR-205* hsa-miR-3662 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP15 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP15 (see all 7)
    OriGene shRNA RFP: ARHGAP15
    OriGene siRNA: ARHGAP15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP15
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARHGAP15 (NM_018460)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP15

    Additional cDNA sequence: 

    AF212222.1 AF217507.1 AF217522.1 AK226014.1 AK303490.1 AK308219.1 AY219338.1 BC016701.2 
    BC038976.1 

    9 DOTS entries:

    DT.316954  DT.99977039  DT.91861911  DT.92430523  DT.65285433  DT.95268221  DT.120942634  DT.92430527 
    DT.92430528 

    24/157 AceView cDNA sequences (see all 157):

    AW468004 AL583351 BX449174 BX280352 BP359003 AA731538 AI400546 BG192457 
    AL543868 BF593750 AA233664 N59846 AA644294 BX094274 BX340749 AA233550 
    AA723688 R44856 AI915381 AI718247 N49790 BM470092 AA001973 BI765032 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP15    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                    -     -     -                     
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for ARHGAP15

    Expression
    for ARHGAP15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAGTGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARHGAP15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB induced-cells (Generation of midbra...)

    See ARHGAP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP15

    SOURCE GeneReport for Unigene cluster: Hs.171011

    UniProtKB/Swiss-Prot: RHG15_HUMAN, Q53QZ3
    Tissue specificity: Expressed in lung, liver and lymphoid cells

        SABiosciences Custom PCR Arrays for ARHGAP15
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP15

    Orthologs
    for ARHGAP15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP15 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARHGAP151 Rho GTPase activating protein 15 80.41(n)
    82.03(a)    		   424303  NM_001008476.1  NP_001008476.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGAP156
    		 --
    		 81(a)
    		 1 ↔ 1
    		 1(101658828-101862565)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000035471 novel protein similar to vertebrate Rho GTPase activating more 64.34(n)
    60.45(a)    		   100003547  NM_001128555.1  NP_001122027.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rga-56
    tag-3256
    		 WW domain-containing protein tag-325
    		 5(a)
    14(a)
    		 possible ortholog
    1 ↔ many
    		 IV(13827861-13844953)
    III(4796804-4802875)


    ENSEMBL Gene Tree for ARHGAP15 (if available)
    TreeFam Gene Tree for ARHGAP15 (if available) 

    Paralogs
    for ARHGAP15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP15 gene
    HMHA12  ARHGAP212  ARHGAP272  CHN22  ARHGAP102  ARHGAP232  ARHGAP92  ARHGAP292  
    CHN12  ARHGAP262  ARHGAP122  OPHN12  GMIP2  ARHGAP422  
    6 SIMAP similar genes for ARHGAP15 using alignment to 3 protein entries:     RHG15_HUMAN (see all proteins):
    ARHGAP12    ARHGAP27    ARHGAP9    CHN1    BCR/ABL fusion    ARHGAP21

    ARHGAP15 for paralogs           About GeneDecksing



    Genomic Variants
    for ARHGAP15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/10274 NCBI SNPs in ARHGAP15 are shown (see all 10274)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112997131,2
    		C,F,--136241673(+) AAGTG-/AAAAAA 1 -- int13Minor allele frequency- A:0.33NA CSA 6
    rs130046511,2
    		C--143884910(+) TATTGG/TTATTT 1 -- us2k1 tfbs31Minor allele frequency- T:0.50NA 2
    rs1830415181,2
    		--143884932(+) TAGTCA/GGATGC 1 -- us2k10--------
    rs1873682301,2
    		--143884975(+) TGGCCA/GGGAGT 1 -- us2k10--------
    rs714232611,2
    		C,--143885045(+) CAAGAG/CATAGA 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1841517351,2
    		--143885086(+) TCTCTA/GCTAAA 1 -- us2k10--------
    rs779315811,2
    		C,--143885131(+) CTGTAA/GTCTCA 1 -- us2k12Minor allele frequency- G:0.06WA NA 122
    rs1875373151,2
    		--143885245(+) ACTCCA/GTAAAA 1 -- us2k10--------
    rs1927899371,2
    		--143885282(+) CTAATC/TTATTT 1 -- us2k10--------
    rs1841404981,2
    		--143885447(+) TACATC/TTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP15 (143848931 - 144098931 bp, first 250kb of ARHGAP15)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ARHGAP15
         2 CNVs: 35737 35738
         2 Indels: 68186 50311

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    Disorders / Diseases
    for ARHGAP15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGAP15 for disorders           About GeneDecksing

    OMIM gene information: 610578    OMIM disorders: --

    2 diseases for ARHGAP15:    About MalaCards
    conduct disorder    trypanosomiasis

    Human Genome Epidemiology (HuGE) Navigator: ARHGAP15 (2 documents)

    Export disorders for ARHGAP15 gene to outside databases

    Publications
    for ARHGAP15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP15 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ARHGAP15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ArhGAP15, a novel human RacGAP protein with GTPase binding property. (PubMed id 12650940)1, 2, 3 Seoh M.L.... Leung T. (2003)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. (PubMed id 21297076)1 Leikauf G.D....Prows D.R. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1 Dick D.M....Bierut L. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    10. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1 Lowe J.K....Friedman J.M. (2009)

    External Searches for ARHGAP15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ARHGAP15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55843 HGNC: 21030 AceView: ARHGAP15 Ensembl:ENSG00000075884 euGenes: HUgn55843
    ECgene: ARHGAP15 H-InvDB: ARHGAP15

    Other Databases showing ARHGAP15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARHGAP15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARHGAP15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGAP15 gene:
    Search GeneIP for patents involving ARHGAP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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