Aliases for ARHGAP15 Gene
External Ids for ARHGAP15 Gene
Previous GeneCards Identifiers for ARHGAP15 Gene
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP15 Gene
ARHGAP15 (Rho GTPase Activating Protein 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot for ARHGAP15 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.