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Aliases for ARHGAP15 Gene

Aliases for ARHGAP15 Gene

  • Rho GTPase Activating Protein 15 2 3 5
  • Rho-Type GTPase-Activating Protein 15 3 4
  • Rho GTPase-Activating Protein 15 3
  • ArhGAP15 4
  • BM046 3

External Ids for ARHGAP15 Gene

Previous GeneCards Identifiers for ARHGAP15 Gene

  • GC02P142204
  • GC02P143909
  • GC02P144097
  • GC02P143720
  • GC02P143603
  • GC02P143565
  • GC02P143848
  • GC02P135878
  • GC02P143091

Summaries for ARHGAP15 Gene

Entrez Gene Summary for ARHGAP15 Gene

  • RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP15 Gene

ARHGAP15 (Rho GTPase Activating Protein 15) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP12.

UniProtKB/Swiss-Prot for ARHGAP15 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP15 Gene

Genomics for ARHGAP15 Gene

Regulatory Elements for ARHGAP15 Gene

Enhancers for ARHGAP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G143544 1.5 ENCODE 11.7 +474.8 474759 1.9 GATA3 HMBOX1 MNT ATF2 ARHGAP15 ENSG00000257640 ENSG00000228655
GH02G143148 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +80.1 80079 5.1 PKNOX1 CHD7 TCF12 ARID3A RELB IKZF2 CREM MTA2 BHLHE40 CEBPB ARHGAP15 GC02P143132 ENSG00000257284
GH02G143261 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +191.5 191473 2.9 PKNOX1 INSM2 FEZF1 ZNF2 RAD21 ZEB1 EGR1 ZNF366 ZNF362 TSHZ1 KYNU ARHGAP15 GC02P143346 ENSG00000257284
GH02G143472 1.4 Ensembl ENCODE dbSUPER 4.9 +403.8 403796 4.0 ATF1 PKNOX1 ARNT TCF12 ZNF766 GATA2 FOS NCOA1 TBX21 ZNF592 ARHGAP15 GC02P143475 GC02P143409
GH02G143488 1 Ensembl ENCODE dbSUPER 5.6 +418.4 418416 1.0 JUND GATA2 JUN FOS ARHGAP15 ENSG00000228655 ENSG00000257640
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP15 Gene

Chromosome:
2
Start:
143,070,968 bp from pter
End:
143,768,352 bp from pter
Size:
697,385 bases
Orientation:
Plus strand

Genomic View for ARHGAP15 Gene

Genes around ARHGAP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP15 Gene

Proteins for ARHGAP15 Gene

  • Protein details for ARHGAP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53QZ3-RHG15_HUMAN
    Recommended name:
    Rho GTPase-activating protein 15
    Protein Accession:
    Q53QZ3
    Secondary Accessions:
    • Q53R36
    • Q53RD7
    • Q53RT6
    • Q53SX9
    • Q584N9
    • Q6PJE6
    • Q86WP1
    • Q8IXX1
    • Q9NRL8
    • Q9NZ77
    • Q9NZ91

    Protein attributes for ARHGAP15 Gene

    Size:
    475 amino acids
    Molecular mass:
    54544 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316, 323, 332; Evidence={ECO:0000305}; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF87324.1; Type=Frameshift; Positions=202, 233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP15 Gene

neXtProt entry for ARHGAP15 Gene

Post-translational modifications for ARHGAP15 Gene

  • Ubiquitination at Lys206 and posLast=327327
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP15 Gene

Domains & Families for ARHGAP15 Gene

Protein Domains for ARHGAP15 Gene

Suggested Antigen Peptide Sequences for ARHGAP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53QZ3

UniProtKB/Swiss-Prot:

RHG15_HUMAN :
  • The PH domain is required for localization to the membrane.
Domain:
  • The PH domain is required for localization to the membrane.
genes like me logo Genes that share domains with ARHGAP15: view

Function for ARHGAP15 Gene

Molecular function for ARHGAP15 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

Gene Ontology (GO) - Molecular Function for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP15: view
genes like me logo Genes that share phenotypes with ARHGAP15: view

Animal Models for ARHGAP15 Gene

MGI Knock Outs for ARHGAP15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP15 Gene

Localization for ARHGAP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP15 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP15 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP15: view

Pathways & Interactions for ARHGAP15 Gene

genes like me logo Genes that share pathways with ARHGAP15: view

Pathways by source for ARHGAP15 Gene

1 BioSystems pathway for ARHGAP15 Gene
3 Reactome pathways for ARHGAP15 Gene

Gene Ontology (GO) - Biological Process for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008360 regulation of cell shape IDA 12650940
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP15: view

No data available for SIGNOR curated interactions for ARHGAP15 Gene

Transcripts for ARHGAP15 Gene

Unigene Clusters for ARHGAP15 Gene

Rho GTPase activating protein 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2:

Relevant External Links for ARHGAP15 Gene

GeneLoc Exon Structure for
ARHGAP15
ECgene alternative splicing isoforms for
ARHGAP15

Expression for ARHGAP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP15 Gene

This gene is overexpressed in Whole Blood (x21.8) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for ARHGAP15 Gene

This gene is overexpressed in Lymph node (15.9), Peripheral blood mononuclear cells (15.3), CD8 Tcells (10.6), and Blymphocyte (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP15 Gene



Protein tissue co-expression partners for ARHGAP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP15 Gene:

ARHGAP15

SOURCE GeneReport for Unigene cluster for ARHGAP15 Gene:

Hs.171011

mRNA Expression by UniProt/SwissProt for ARHGAP15 Gene:

Q53QZ3-RHG15_HUMAN
Tissue specificity: Expressed in lung, liver and lymphoid cells.

Evidence on tissue expression from TISSUES for ARHGAP15 Gene

  • Bone marrow(4.4)
  • Liver(4.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with ARHGAP15: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP15 Gene

Orthologs for ARHGAP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP15 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia ARHGAP15 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia ARHGAP15 34 35
  • 92.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP15 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap15 34 16 35
  • 88.37 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap15 34
  • 86.75 (n)
chicken
(Gallus gallus)
Aves ARHGAP15 34 35
  • 80.48 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP15 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485536 34
  • 68.08 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgap15 34 35
  • 64.27 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-325 34 35
  • 46.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for ARHGAP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP15 Gene

ENSEMBL:
Gene Tree for ARHGAP15 (if available)
TreeFam:
Gene Tree for ARHGAP15 (if available)

Paralogs for ARHGAP15 Gene

(6) SIMAP similar genes for ARHGAP15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP15: view

Variants for ARHGAP15 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000613 -- 143,352,815(+) CTGTC(A/C)CCTTA intron-variant
rs1000002339 -- 143,418,317(+) GACAC(C/G)TGTTG intron-variant
rs1000004467 -- 143,393,496(+) TGGGA(A/G)GCGAA intron-variant
rs1000005137 -- 143,664,439(+) TTATA(C/G)CACTA intron-variant
rs1000015005 -- 143,460,699(+) CTTTA(A/C)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP15 Gene

Variant ID Type Subtype PubMed ID
dgv4086n100 CNV gain 25217958
esv26609 CNV gain 19812545
esv2667585 CNV deletion 23128226
esv2670420 CNV deletion 23128226
esv2672231 CNV deletion 23128226
esv2720910 CNV deletion 23290073
esv2720911 CNV deletion 23290073
esv2720912 CNV deletion 23290073
esv2720913 CNV deletion 23290073
esv2720914 CNV deletion 23290073
esv3303333 CNV mobile element insertion 20981092
esv3309422 CNV mobile element insertion 20981092
esv3328174 CNV insertion 20981092
esv3397923 CNV insertion 20981092
esv3560275 CNV deletion 23714750
esv3560276 CNV deletion 23714750
esv3560278 CNV deletion 23714750
esv3575308 CNV gain 25503493
esv3584098 CNV loss 25503493
esv3592749 CNV loss 21293372
esv3592750 CNV loss 21293372
esv3592751 CNV loss 21293372
esv3592753 CNV loss 21293372
esv3592756 CNV gain 21293372
esv3592757 CNV loss 21293372
esv994769 CNV insertion 20482838
nsv1001991 CNV loss 25217958
nsv1114140 CNV deletion 24896259
nsv1117261 CNV tandem duplication 24896259
nsv1127769 CNV deletion 24896259
nsv1139740 CNV duplication 24896259
nsv1150405 CNV duplication 26484159
nsv213976 CNV deletion 16902084
nsv2955 CNV insertion 18451855
nsv2956 CNV insertion 18451855
nsv459707 CNV loss 19166990
nsv477328 CNV novel sequence insertion 20440878
nsv515703 CNV loss 19592680
nsv519096 CNV loss 19592680
nsv523591 CNV loss 19592680
nsv524638 CNV loss 19592680
nsv583244 CNV loss 21841781
nsv583245 CNV loss 21841781
nsv821742 CNV gain 20364138
nsv821744 CNV gain 20364138
nsv821745 CNV loss 20364138
nsv955259 CNV duplication 24416366

Variation tolerance for ARHGAP15 Gene

Residual Variation Intolerance Score: 9.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP15 Gene

Disorders for ARHGAP15 Gene

Relevant External Links for ARHGAP15

Genetic Association Database (GAD)
ARHGAP15
Human Genome Epidemiology (HuGE) Navigator
ARHGAP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP15

No disorders were found for ARHGAP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP15 Gene

Publications for ARHGAP15 Gene

  1. ArhGAP15, a novel human RacGAP protein with GTPase binding property. (PMID: 12650940) Seoh M.L. … Leung T. (FEBS Lett. 2003) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64

Products for ARHGAP15 Gene

Sources for ARHGAP15 Gene

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