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Aliases for ARHGAP12 Gene

Aliases for ARHGAP12 Gene

  • Rho GTPase Activating Protein 12 2 3 5
  • Rho-Type GTPase-Activating Protein 12 4

External Ids for ARHGAP12 Gene

Previous GeneCards Identifiers for ARHGAP12 Gene

  • GC10U990129
  • GC10M032244
  • GC10M032099
  • GC10M032098
  • GC10M032134

Summaries for ARHGAP12 Gene

Entrez Gene Summary for ARHGAP12 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARHGAP12 Gene

ARHGAP12 (Rho GTPase Activating Protein 12) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of RAC1 activity and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP27.

UniProtKB/Swiss-Prot for ARHGAP12 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP12 Gene

Genomics for ARHGAP12 Gene

Regulatory Elements for ARHGAP12 Gene

Enhancers for ARHGAP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G031938 1.5 Ensembl ENCODE dbSUPER 5.3 -13.1 -13149 7.3 FOXA2 PKNOX1 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP5 ZHX2 KIF5B ENSG00000206660 ARHGAP12 GC10P031934 GC10P031969
GH10G031946 1.5 Ensembl ENCODE dbSUPER 5.2 -18.8 -18800 2.0 FOXA2 ARID4B SIN3A YY1 ZNF121 ELK1 ZNF143 FOS REST MIER2 ARHGAP12 GC10P031934 GC10P031969
GH10G031961 1.3 Ensembl ENCODE dbSUPER 5.2 -34.2 -34231 4.0 CTCF KLF1 NFIB ZFP64 CEBPG RAD21 ZNF366 FOSL2 FOS NFE2 KIF5B ARHGAP12 GC10P031969 GC10P031934
GH10G031862 1.2 Ensembl ENCODE 5.1 +66.4 66375 0.6 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF766 GATA2 ZHX2 REST SMARCA4 KIF5B ARHGAP12 HMGB1P7 ENSG00000222412
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP12 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARHGAP12 Gene

31,805,398 bp from pter
31,928,876 bp from pter
123,479 bases
Minus strand

Genomic View for ARHGAP12 Gene

Genes around ARHGAP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP12 Gene

Proteins for ARHGAP12 Gene

  • Protein details for ARHGAP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 12
    Protein Accession:
    Secondary Accessions:
    • B1ANY0
    • B1ANY1
    • B1ANY2
    • Q504X1
    • Q86UB3
    • Q8IWW7
    • Q8N3L1
    • Q9NT76

    Protein attributes for ARHGAP12 Gene

    846 amino acids
    Molecular mass:
    96254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP12 Gene


neXtProt entry for ARHGAP12 Gene

Post-translational modifications for ARHGAP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP12 Gene

Domains & Families for ARHGAP12 Gene

No data available for UniProtKB/Swiss-Prot for ARHGAP12 Gene

Function for ARHGAP12 Gene

Molecular function for ARHGAP12 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with ARHGAP12: view
genes like me logo Genes that share phenotypes with ARHGAP12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ARHGAP12

CRISPR Products

miRNA for ARHGAP12 Gene

miRTarBase miRNAs that target ARHGAP12

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP12 Gene

Localization for ARHGAP12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP12 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP12 Gene

Pathways & Interactions for ARHGAP12 Gene

genes like me logo Genes that share pathways with ARHGAP12: view

Pathways by source for ARHGAP12 Gene

3 Reactome pathways for ARHGAP12 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP12 Gene

Gene Ontology (GO) - Biological Process for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002011 morphogenesis of an epithelial sheet IMP 23201090
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP12: view

No data available for SIGNOR curated interactions for ARHGAP12 Gene

Drugs & Compounds for ARHGAP12 Gene

No Compound Related Data Available

Transcripts for ARHGAP12 Gene

Unigene Clusters for ARHGAP12 Gene

Rho GTPase activating protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP6: -

ExUns: 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -
SP7: -
SP8: -

Relevant External Links for ARHGAP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP12 Gene

This gene is overexpressed in Fetal Brain (13.7), Heart (9.8), Islet of Langerhans (6.7), and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP12 Gene

Protein tissue co-expression partners for ARHGAP12 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP12 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP12 Gene:


Evidence on tissue expression from TISSUES for ARHGAP12 Gene

  • Liver(4.3)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with ARHGAP12: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP12 Gene

Orthologs for ARHGAP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP12 34 35
  • 99.72 (n)
(Canis familiaris)
Mammalia ARHGAP12 34 35
  • 92.76 (n)
(Rattus norvegicus)
Mammalia Arhgap12 34
  • 89.1 (n)
(Mus musculus)
Mammalia Arhgap12 34 16 35
  • 89.06 (n)
(Bos Taurus)
Mammalia ARHGAP12 34 35
  • 88.51 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGAP12 35
  • 87 (a)
(Monodelphis domestica)
Mammalia ARHGAP12 35
  • 85 (a)
(Gallus gallus)
Aves ARHGAP12 34 35
  • 78.61 (n)
(Anolis carolinensis)
Reptilia ARHGAP12 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap12 34
  • 71.96 (n)
Str.20319 34
African clawed frog
(Xenopus laevis)
Amphibia arhgap12-prov 34
(Danio rerio)
Actinopterygii arhgap12b 34
  • 62.42 (n)
arhgap12a 35
  • 57 (a)
zgc73239 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2619 34
(Caenorhabditis elegans)
Secernentea tag-325 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for ARHGAP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP12 Gene

Gene Tree for ARHGAP12 (if available)
Gene Tree for ARHGAP12 (if available)

Paralogs for ARHGAP12 Gene

Variants for ARHGAP12 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000026114 -- 31,891,030(+) TTTAG(-/A)AAAAA intron-variant
rs1000027426 -- 31,928,964(+) AGGGG(C/G)TGCGG intron-variant, upstream-variant-2KB
rs1000043857 -- 31,891,350(+) AGTTA(C/G)GCTGG intron-variant
rs1000067292 -- 31,889,340(+) TTGCT(C/T)TGATT intron-variant
rs1000071350 -- 31,847,690(+) GGGAG(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP12 Gene

Variant ID Type Subtype PubMed ID
esv2659410 CNV deletion 23128226
esv3307119 CNV mobile element insertion 20981092
esv3309984 CNV mobile element insertion 20981092
esv3357421 CNV insertion 20981092
esv3411749 CNV insertion 20981092
esv3622817 CNV loss 21293372
nsv1038087 CNV gain 25217958
nsv1050608 CNV loss 25217958
nsv24963 CNV deletion 16902084
nsv947818 CNV duplication 23825009

Variation tolerance for ARHGAP12 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP12 Gene

Disorders for ARHGAP12 Gene

Relevant External Links for ARHGAP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGAP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP12 Gene

Publications for ARHGAP12 Gene

  1. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PMID: 18984674) Argyropoulos G. … Rankinen T. (Physiol. Genomics 2009) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and characterization of ARHGAP12, a novel human rhoGAP gene. (PMID: 11854031) Zhang Z. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3 64

Products for ARHGAP12 Gene

Sources for ARHGAP12 Gene

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