Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGAP12 Gene

protein-coding GIFtS: 54
GCID: GC10M032134

Rho GTPase activating protein 12

Explore 1 disease affiliated with
ARHGAP12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 12¹ ²
Rho-Type GTPase-Activating Protein 12² ³
FLJ10971¹
FLJ20737¹
FLJ21785¹
Rho GTPase-Activating Protein 12²

External Ids:	HGNC: 16348¹	Entrez Gene: 94134²	Ensembl: ENSG00000165322⁷	OMIM: 610577⁵	UniProtKB: Q8IWW6³

Export aliases for ARHGAP12 gene to outside databases

Previous GC identifers: GC10U990129 GC10M031810 GC10M032244 GC10M032099 GC10M032098

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP12:

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP)

metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion

and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

(provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGAP12 gene promoter:
USF1 p53 Pbx1a AML1a STAT5A c-Ets-1 N-Myc S8 USF-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ARHGAP12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.22 Ensembl cytogenetic band: 10p11.22 HGNC cytogenetic band: 10p11.22

ARHGAP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP12 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M032134: view genomic region (about GC identifiers)

Start:	32,094,365 bp from pter	End:	32,217,770 bp from pter
Size:	123,406 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 12

Size: 846 amino acids; 96254 Da

Secondary accessions: B1ANY0 B1ANY1 B1ANY2 Q86UB3 Q8IWW7 Q8N3L1 Q9NT76

Alternative splicing: 3 isoforms: Q8IWW6-1 Q8IWW6-2 Q8IWW6-3

Explore the universe of human proteins at neXtProt for ARHGAP12: NX_Q8IWW6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWW6

ARHGAP12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001257624.1 NP_001257625.1 NP_001257626.1 NP_001257627.1 NP_001257628.1 NP_060757.4

ENSEMBL proteins:

ENSP00000310984 ENSP00000364399 ENSP00000345808 ENSP00000398050 ENSP00000379448

ENSP00000364394

Reactome Protein details: Q8IWW6
Human Recombinant Protein Products for ARHGAP12:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ARHGAP12 OriGene Custom Protein Services for ARHGAP12
	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP12
	Novus Biologicals ARHGAP12 Protein Novus Biologicals ARHGAP12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ARHGAP12

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--

ARHGAP12 for ontologies About GeneDecksing

ARHGAP12 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ARHGAP12
	GenScript Custom Superior Antibodies Services for ARHGAP12
	Novus Biologicals ARHGAP12 Antibodies
	Abcam antibodies for ARHGAP12
	Uscn Antibodies for ARHGAP12
	Search ThermoFisher Antibodies for ARHGAP12

Assay Products for ARHGAP12:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ARHGAP12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ARHGAP12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP12 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

IPR001452 SH3_domain

IPR001202 WW_Rsp5_WWP

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q8IWW6

ProtoNet protein and cluster: Q8IWW6

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB001452 SH3 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6

Similarity: Contains 1 PH domain

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SH3 domain

Similarity: Contains 2 WW domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHG12_HUMAN, Q8IWW6

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--
GO:0005543	phospholipid binding	IEA	--

ARHGAP12 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Arhgap12):

normal

ARHGAP12 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARHGAP12

miRNA Products:		OriGene 3'-UTR Clone: ARHGAP12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP12
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP12 (see all 40):
		hsa-miR-106a hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP12 (see all 7) OriGene shRNA RFP: ARHGAP12 OriGene siRNA: ARHGAP12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP12
		Sirion Biotech Custom design and validation of potent shRNA sequences against ARHGAP12

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ARHGAP12
			Sirion Biotech Customized adenovirus for overexpression of ARHGAP12 Sirion Biotech Customized adenovirus for potent knockdown of ARHGAP12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARHGAP12 (NM_018287)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARHGAP12
		Search LifeMap BioReagents cell lines for ARHGAP12
		Sirion Biotech Customized stable knockdown cell line services for ARHGAP12 Sirion Biotech Customized inducible knockdown cell line services for ARHGAP12 Sirion Biotech Customized stable overexpressing cell line services for ARHGAP12 Sirion Biotech Customized inducible overexpressing cell line services for ARHGAP12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP12

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Regulation of RAC1 activity

G-protein signaling Regulation of RAC1 activity

1.00

G-protein signaling_Regulation of RAC1 activity

0.88

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ARHGAP12

G-protein signaling Regulation of RAC1 activity

1 GeneGo (Thomson Reuters) Pathway for ARHGAP12

G-protein signaling Regulation of RAC1 activity

3 Reactome Pathways for ARHGAP12

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

ARHGAP12 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP12

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for ARHGAP12 (Q8IWW6³ ENSP00000345808⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYL12B	O14950³	I2D: score=5
GRB2	ENSP00000339007⁴	STRING: ENSP00000339007
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

ARHGAP12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGAP12
Search CenterWatch for drugs/clinical trials and news about ARHGAP12 / RHG12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARHGAP12 gene (6 alternative transcripts):

NM_001270695.1 NM_001270696.1 NM_001270697.1 NM_001270698.1 NM_001270699.1 NM_018287.6

Unigene Cluster for ARHGAP12:

Rho GTPase activating protein 12

Hs.499264 [show with all ESTs]

Unigene Representative Sequence: NM_018287

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311380 ENST00000375250(uc001iwc.1 uc009xlq.1) ENST00000492028

ENST00000497085(uc001ivw.1) ENST00000493008(uc001ivx.1) ENST00000344936(uc001ivy.1 uc001ivz.1 uc009xls.2 uc001iwb.1 uc009xlr.1)

ENST00000477117 ENST00000497103 ENST00000454919 ENST00000396144 ENST00000375245

miRNA Products:		OriGene 3'-UTR Clone: ARHGAP12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP12
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP12 (see all 40):
		hsa-miR-106a hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP12 (see all 7) OriGene shRNA RFP: ARHGAP12 OriGene siRNA: ARHGAP12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP12
		Sirion Biotech Custom design and validation of potent shRNA sequences against ARHGAP12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARHGAP12 (NM_018287)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARHGAP12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP12

Additional cDNA sequence:

AF131804.1 AK000744.1 AK001833.1 AK025438.1 AK091182.1 AK127611.1 AK315066.1 AL137485.1

AL834250.2 AY033594.1 AY033595.1 BC051811.1 BC094719.1 BC115362.2 BC115363.2 CR936681.1

18 DOTS entries:

DT.97844551 DT.100026780 DT.101983907 DT.113603 DT.100786091 DT.101983908 DT.100786095 DT.100786089

DT.121255549 DT.100786087 DT.121255592 DT.437344 DT.102826405 DT.113602 DT.121255534 DT.97831310

DT.427781 DT.75192650

24/182 AceView cDNA sequences (see all 182):

CR613881 CD676922 BU689789 NM_018287 AK000744 BX108249 AF131804 AK001833

BU509814 BX112981 Z43322 CB068530 BM975446 Z39397 AL137485 BX952225

AU118191 BP338326 AA280616 BM983613 H44459 AY033594 BM718700 AL712774

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP12 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^	19	^
SP1:																									-														-						-
SP2:																							-		-														-						-
SP3:																	-								-														-						-
SP4:					-		-
SP5:

ExUns:	20	^	21a	·	21b	·	21c
SP1:	-
SP2:	-
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for ARHGAP12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGAP12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGTCTAA

About this image

ARHGAP12 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Bone

Endochondral Facial Bones

Bone

Bone

Eye

Gut Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARHGAP12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGAP12

SOURCE GeneReport for Unigene cluster: Hs.499264

SABiosciences Custom PCR Arrays for ARHGAP12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARHGAP12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP12 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARHGAP12¹	Rho GTPase activating protein 12	78.68(n) 83.71(a)		420473 XM_418575.3 XP_418575.3
lizard (Anolis carolinensis)	Reptilia	ARHGAP12⁶	--	79(a)	1 ↔ 1	6(12654376-12706735)
African clawed frog (Xenopus laevis)	Amphibia	arhgap12-prov²	Rho GTPase activating protein 12	76.71(n)		BC046844.1
zebrafish (Danio rerio)	Actinopterygii	zgc73239²	hypothetical protein MGC73239	74.8(n)		393848 BC063321.1
worm (Caenorhabditis elegans)	Secernentea	rga-5⁶ tag-325⁶	WW domain-containing protein tag-325	5(a) 15(a)	possible ortholog 1 ↔ many	IV(13827861-13844953) III(4796804-4802875)

ENSEMBL Gene Tree for ARHGAP12 (if available)
TreeFam Gene Tree for ARHGAP12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGAP12 gene

HMHA1² ARHGAP21² ARHGAP27² CHN2² ARHGAP10² ARHGAP23² ARHGAP9² ARHGAP29²

CHN1² ARHGAP26² ARHGAP15² OPHN1² GMIP² ARHGAP42²

18/54 SIMAP similar genes for ARHGAP12 using alignment to 7 protein entries: RHG12_HUMAN (see all proteins) (see all similar genes):

ARHGAP15 OPHN1 ARHGAP10 DKFZp667D142 ARHGAP17 ARHGAP18

ARHGAP42 MYO9B MYO9B variant protein CHN2 CHN1 ARHGAP1

ARHGAP44 BCR CHN2-3 ARHGAP31 ARHGAP26 ARHGAP40

ARHGAP12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116236428^1,2	F	--	32093904(+)	`CACTGC/TTATCT`	6	--	ds500¹		1		WA	118
rs190535473^1,2		--	32093973(+)	`GGTCTC/TCATGT`	6	--	ds500¹		0	--	--	--	--
rs112246982^1,2	C	--	32093979(+)	`CATGTA/GTNNNN`	6	--	ds500¹		2		NA	122
rs7905471^1,2	C,F,H	--	32094004(+)	`TTCACT/CTGTAT`	6	--	ds500¹		12		NS EA NA CSA WA	922
rs181826452^1,2		--	32094264(+)	`TGTTTC/TTCTTC`	6	--	ds500¹		0	--	--	--	--
rs140970615^1,2		--	32094302(+)	`TATACC/TTTCTT`	6	--	ds500¹		0	--	--	--	--
rs185408801^1,2		--	32094334(+)	`TTTCAA/GTGACA`	6	--	ut3¹		0	--	--	--	--
rs144780762^1,2		--	32094401(+)	`TAATAC/TATTTT`	6	--	ut3¹		0	--	--	--	--
rs11008652^1,2	C,F,H	--	32094413(+)	`TACTAT/CAAAAC`	6	--	ut3¹ ese³		12		NS EA WA NA	1314
rs11008653^1,2	C,F,A,H	--	32094500(+)	`AAAACG/ACAAGA`	6	--	ut3¹ ese³		15		NA NS EA WA	1524

HapMap Linkage Disequilibrium report for ARHGAP12 (32094365 - 32217770 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ARHGAP12
5 CNVs: 75169 85173 75171 75170 85174
1 Indel: 11468

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP12

DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARHGAP12 for disorders           About GeneDecksing

OMIM gene information: 610577    OMIM disorders: --

1 disease for ARHGAP12:    About MalaCards

alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: ARHGAP12 (2 documents)

Export disorders for ARHGAP12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARHGAP12 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ARHGAP12)

Utopia: connect your pdf to the dynamic
world of online information

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and characterization of ARHGAP12, a novel human rhoGAP gene. (PubMed id 11854031)^{1, 3} Zhang Z....Mao Y. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)¹ Argyropoulos G....Rankinen T. (2009)
Met-driven invasive growth involves transcriptional r egulation of Arhgap12. (PubMed id 18504429)¹ Gentile A....Medico E. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 94134	HGNC: 16348	AceView: ARHGAP12	Ensembl:ENSG00000165322	euGenes: HUgn94134
ECgene: ARHGAP12	H-InvDB: ARHGAP12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARHGAP12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARHGAP12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARHGAP12 gene:
Search GeneIP for patents involving ARHGAP12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ARHGAP12
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP12		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP12
	OriGene Protein Over-expression Lysate for ARHGAP12		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ARHGAP12		OriGene 3'-UTR Clone for ARHGAP12
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP12
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ARHGAP12		OriGene Custom Protein Services for ARHGAP12
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP12
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP12
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP12
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP12
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP12

	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP12		GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP12
	GenScript Custom Assay Services for ARHGAP12		GenScript Custom Superior Antibodies Services for ARHGAP12
	GenScript Custom overexpressing Cell Line Services for ARHGAP12		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ARHGAP12 promoter
	Search Chromatin IP Primers for ARHGAP12
	RT² qPCR Primer Assay in human, mouse, rat ARHGAP12
	Search GNC Networks for ARHGAP12
	SABiosciences Custom PCR Arrays for ARHGAP12

Search Tocris compounds for ARHGAP12

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ARHGAP12 antibodies
	ARHGAP12 proteins
	ARHGAP12 lysates

	Antibodies for ARHGAP12
	See all of Abcam's Antibodies, Kits and Proteins for ARHGAP12
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ARHGAP12 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ARHGAP12

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP12

	SwitchGear 3'UTR luciferase reporter plasmids for ARHGAP12
	Browse SwitchGear Promoter luciferase reporter plasmids for ARHGAP12

Search ThermoFisher Antibodies for ARHGAP12

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP12

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARHGAP12

Sirion Biotech Customized:

	stable knockdown cell line services for ARHGAP12
	inducible knockdown cell line services for ARHGAP12
	design and validation of potent shRNA sequences against ARHGAP12
	adenovirus for potent knockdown of ARHGAP12
	adenovirus for overexpression of ARHGAP12
	stable overexpressing cell line services for ARHGAP12
	inducible overexpressing cell line services for ARHGAP12

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARHGAP12 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ARHGAP12 Gene

Rho GTPase activating protein 12

Aliases
for ARHGAP12 gene

Summaries
for ARHGAP12 gene

Genomic Views
for ARHGAP12 gene

Proteins
for ARHGAP12 gene

Protein Domains /
Families
for ARHGAP12 gene

Function
for ARHGAP12 gene

Pathways & Interactions
for ARHGAP12 gene

Drugs & Compounds
for ARHGAP12 gene

Transcripts
for ARHGAP12 gene

Expression
for ARHGAP12 gene

Orthologs
for ARHGAP12 gene

Paralogs
for ARHGAP12 gene

Genomic Variants
for ARHGAP12 gene

Disorders / Diseases
for ARHGAP12 gene

Publications
for ARHGAP12 gene

External Searches for ARHGAP12 gene

Genome Databases showing ARHGAP12 gene

Other Databases showing ARHGAP12 gene

Specialized Databases showing ARHGAP12 gene

Intellectual Property
for ARHGAP12 gene

Products
for ARHGAP12 gene

View Random Gene

Advanced Search

Export list of displayed genes

ARHGAP12 Gene

Rho GTPase activating protein 12

Aliasesfor ARHGAP12 gene

Summariesfor ARHGAP12 gene

Genomic Viewsfor ARHGAP12 gene

Proteinsfor ARHGAP12 gene

Protein Domains /Familiesfor ARHGAP12 gene

Functionfor ARHGAP12 gene

Pathways & Interactionsfor ARHGAP12 gene

Drugs & Compoundsfor ARHGAP12 gene

Transcriptsfor ARHGAP12 gene

Expression for ARHGAP12 gene

Orthologsfor ARHGAP12 gene

Paralogsfor ARHGAP12 gene

Genomic Variantsfor ARHGAP12 gene

Disorders / Diseasesfor ARHGAP12 gene

Publicationsfor ARHGAP12 gene

External Searches for ARHGAP12 gene

Genome Databases showing ARHGAP12 gene

Other Databases showing ARHGAP12 gene

Specialized Databases showing ARHGAP12 gene

Intellectual Propertyfor ARHGAP12 gene

Productsfor ARHGAP12 gene

View Random Gene

Aliases
for ARHGAP12 gene

Summaries
for ARHGAP12 gene

Genomic Views
for ARHGAP12 gene

Proteins
for ARHGAP12 gene

Protein Domains /
Families
for ARHGAP12 gene

Function
for ARHGAP12 gene

Pathways & Interactions
for ARHGAP12 gene

Drugs & Compounds
for ARHGAP12 gene

Transcripts
for ARHGAP12 gene

Expression
for ARHGAP12 gene

Orthologs
for ARHGAP12 gene

Paralogs
for ARHGAP12 gene

Genomic Variants
for ARHGAP12 gene

Disorders / Diseases
for ARHGAP12 gene

Publications
for ARHGAP12 gene

Intellectual Property
for ARHGAP12 gene

Products
for ARHGAP12 gene