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Aliases for ARHGAP12 Gene

Aliases for ARHGAP12 Gene

  • Rho GTPase Activating Protein 12 2 3
  • Rho-Type GTPase-Activating Protein 12 4

External Ids for ARHGAP12 Gene

Previous GeneCards Identifiers for ARHGAP12 Gene

  • GC10U990129
  • GC10M032244
  • GC10M032099
  • GC10M032098
  • GC10M032134

Summaries for ARHGAP12 Gene

Entrez Gene Summary for ARHGAP12 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARHGAP12 Gene

ARHGAP12 (Rho GTPase Activating Protein 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for ARHGAP12 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP12 Gene

Genomics for ARHGAP12 Gene

Regulatory Elements for ARHGAP12 Gene

Genomic Location for ARHGAP12 Gene

Start:
31,805,398 bp from pter
End:
31,928,876 bp from pter
Size:
123,479 bases
Orientation:
Minus strand

Genomic View for ARHGAP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP12 Gene

Proteins for ARHGAP12 Gene

  • Protein details for ARHGAP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWW6-RHG12_HUMAN
    Recommended name:
    Rho GTPase-activating protein 12
    Protein Accession:
    Q8IWW6
    Secondary Accessions:
    • B1ANY0
    • B1ANY1
    • B1ANY2
    • Q504X1
    • Q86UB3
    • Q8IWW7
    • Q8N3L1
    • Q9NT76

    Protein attributes for ARHGAP12 Gene

    Size:
    846 amino acids
    Molecular mass:
    96254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP12 Gene

Proteomics data for ARHGAP12 Gene at MOPED

Post-translational modifications for ARHGAP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP12 Gene

No data available for DME Specific Peptides for ARHGAP12 Gene

Domains for ARHGAP12 Gene

Gene Families for ARHGAP12 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Graphical View of Domain Structure for InterPro Entry

Q8IWW6

UniProtKB/Swiss-Prot:

RHG12_HUMAN :
  • Q8IWW6
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with ARHGAP12: view

Function for ARHGAP12 Gene

Molecular function for ARHGAP12 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGAP12: view

Phenotypes for ARHGAP12 Gene

MGI mutant phenotypes for ARHGAP12:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ARHGAP12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP12 Gene

Localization for ARHGAP12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP12 Gene COMPARTMENTS Subcellular localization image for ARHGAP12 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP12 Gene

Pathways for ARHGAP12 Gene

genes like me logo Genes that share pathways with ARHGAP12: view

Pathways by source for ARHGAP12 Gene

3 Reactome pathways for ARHGAP12 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP12 Gene

Interacting Proteins for ARHGAP12 Gene

Gene Ontology (GO) - Biological Process for ARHGAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002011 morphogenesis of an epithelial sheet IMP 23201090
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP12: view

Transcripts for ARHGAP12 Gene

Unigene Clusters for ARHGAP12 Gene

Rho GTPase activating protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:

Relevant External Links for ARHGAP12 Gene

GeneLoc Exon Structure for
ARHGAP12
ECgene alternative splicing isoforms for
ARHGAP12

Expression for ARHGAP12 Gene

mRNA expression in normal human tissues for ARHGAP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP12 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP12 Gene Hs.499264

genes like me logo Genes that share expressions with ARHGAP12: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP12 Gene

Orthologs for ARHGAP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP12 35
  • 99.72 (n)
  • 99.64 (a)
ARHGAP12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP12 35
  • 88.51 (n)
  • 91.92 (a)
ARHGAP12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP12 35
  • 92.76 (n)
  • 95.35 (a)
ARHGAP12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap12 35
  • 89.06 (n)
  • 91.53 (a)
Arhgap12 16
Arhgap12 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP12 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP12 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap12 35
  • 89.1 (n)
  • 92.92 (a)
chicken
(Gallus gallus)
Aves ARHGAP12 35
  • 78.61 (n)
  • 83.51 (a)
ARHGAP12 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP12 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arhgap12-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap12 35
  • 71.96 (n)
  • 72.86 (a)
Str.20319 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2619 35
zebrafish
(Danio rerio)
Actinopterygii arhgap12a 36
  • 57 (a)
OneToOne
arhgap12b 35
  • 62.42 (n)
  • 66.79 (a)
zgc73239 35
worm
(Caenorhabditis elegans)
Secernentea tag-325 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ARHGAP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP12 Gene

ENSEMBL:
Gene Tree for ARHGAP12 (if available)
TreeFam:
Gene Tree for ARHGAP12 (if available)

Paralogs for ARHGAP12 Gene

genes like me logo Genes that share paralogs with ARHGAP12: view

Variants for ARHGAP12 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs951242 -- 31,824,101(-) GGAAG(C/T)AAGAG intron-variant
rs998542 -- 31,810,528(-) AGTCC(G/T)AAGAT intron-variant
rs998543 -- 31,810,448(-) CATCT(A/G)CTGAA intron-variant
rs1007082 -- 31,810,459(-) ATCTC(A/T)CCAGG intron-variant
rs1023207 -- 31,805,962(+) ACAGA(A/C)TTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP12 Gene

Variant ID Type Subtype PubMed ID
esv2659410 CNV Deletion 23128226
esv274256 CNV Insertion 20981092
esv271395 CNV Insertion 20981092
nsv24963 CNV Loss 16902084

Relevant External Links for ARHGAP12 Gene

HapMap Linkage Disequilibrium report
ARHGAP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP12 Gene

Disorders for ARHGAP12 Gene

Relevant External Links for ARHGAP12

Genetic Association Database (GAD)
ARHGAP12
Human Genome Epidemiology (HuGE) Navigator
ARHGAP12
genes like me logo Genes that share disorders with ARHGAP12: view

No data available for UniProtKB/Swiss-Prot for ARHGAP12 Gene

Publications for ARHGAP12 Gene

  1. Cloning and characterization of ARHGAP12, a novel human rhoGAP gene. (PMID: 11854031) Zhang Z. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3
  2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  3. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PMID: 18984674) Argyropoulos G. … Rankinen T. (Physiol. Genomics 2009) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for ARHGAP12 Gene

Sources for ARHGAP12 Gene

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