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ARHGAP12 Gene

protein-coding   GIFtS: 58
GCID: GC10M032134

Rho GTPase Activating Protein 12

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 121 2
Rho-Type GTPase-Activating Protein 122 3
Rho GTPase-Activating Protein 122

External Ids:    HGNC: 163481   Entrez Gene: 941342   Ensembl: ENSG000001653227   OMIM: 6105775   UniProtKB: Q8IWW63   

Export aliases for ARHGAP12 gene to outside databases

Previous GC identifers: GC10U990129 GC10M031810 GC10M032244 GC10M032099 GC10M032098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP12 Gene:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP)
metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell
invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for ARHGAP12 Gene:
ARHGAP12 (Rho GTPase activating protein 12) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP12 gene promoter:
         USF1   p53   Pbx1a   AML1a   STAT5A   c-Ets-1   N-Myc   S8   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARHGAP12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.22   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.22

ARHGAP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP12 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M032134:  view genomic region     (about GC identifiers)

Start:
32,094,365 bp from pter      End:
32,217,770 bp from pter
Size:
123,406 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 12  
Size: 846 amino acids; 96254 Da
Secondary accessions: B1ANY0 B1ANY1 B1ANY2 Q504X1 Q86UB3 Q8IWW7 Q8N3L1 Q9NT76
Alternative splicing: 4 isoforms:  Q8IWW6-1   Q8IWW6-2   Q8IWW6-3   Q8IWW6-4   

Explore the universe of human proteins at neXtProt for ARHGAP12: NX_Q8IWW6

Explore proteomics data for ARHGAP12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001257624.1  NP_001257625.1  NP_001257626.1  NP_001257627.1  NP_001257628.1  NP_060757.4  

    ENSEMBL proteins: 
     ENSP00000310984   ENSP00000364399   ENSP00000345808   ENSP00000398050   ENSP00000379448  
     ENSP00000364394  
    Reactome Protein details: Q8IWW6

    ARHGAP12 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGAP12

     
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    antibodies-online proteins for ARHGAP12 (2 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGAP: Rho GTPase activating proteins

    Selected InterPro protein domains (see all 7):
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR015767 Rho_GTPase_activating

    Graphical View of Domain Structure for InterPro Entry Q8IWW6

    ProtoNet protein and cluster: Q8IWW6

    3 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: RHG12_HUMAN, Q8IWW6
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 2 WW domains


    Find genes that share domains with ARHGAP12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG12_HUMAN, Q8IWW6
    Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ARHGAP12           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgap12):
     normal 

    Find genes that share phenotypes with ARHGAP12           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARHGAP12

    miRNA
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    miRTarBase miRNAs that target ARHGAP12:
    hsa-mir-20a-5p (MIRT031082), hsa-mir-93-5p (MIRT027984), hsa-mir-340-5p (MIRT019545), hsa-mir-128-3p (MIRT021898), hsa-mir-335-5p (MIRT016782), hsa-mir-130b-3p (MIRT020135), hsa-mir-142-3p (MIRT021547), hsa-mir-181a-5p (MIRT025116), hsa-mir-125a-5p (MIRT045776), hsa-mir-19b-3p (MIRT031108)

    Block miRNA regulation of human, mouse, rat ARHGAP12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP12 (see all 40):
    hsa-miR-106a hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGAP12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARHGAP12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP12 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity


    Find genes that share SuperPaths with ARHGAP12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARHGAP12
        G-protein signaling Regulation of RAC1 activity


    1 Reactome Pathway for ARHGAP12
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP12
    Interactions:

        Search GeneGlobe Interaction Network for ARHGAP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP12 (Q8IWW63 ENSP000003458084) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYL12BO149503I2D: score=5 
    GRB2ENSP000003390074STRING: ENSP00000339007
    NIFKENSP000002858144STRING: ENSP00000285814
    RALBP1ENSP000000193174STRING: ENSP00000019317
    PPP6CENSP000003921474STRING: ENSP00000392147
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARHGAP12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP12 (RHG12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP12 gene (6 alternative transcripts): 
    NM_001270695.1  NM_001270696.1  NM_001270697.1  NM_001270698.1  NM_001270699.1  NM_018287.6  

    Unigene Cluster for ARHGAP12:

    Rho GTPase activating protein 12
    Hs.499264  [show with all ESTs]
    Unigene Representative Sequence: NM_018287
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311380 ENST00000375250(uc001iwc.1 uc009xlq.1) ENST00000492028
    ENST00000497085(uc001ivw.1) ENST00000493008(uc001ivx.1) ENST00000344936(uc001ivy.1 uc001ivz.1 uc009xls.2 uc001iwb.1 uc009xlr.1)
    ENST00000497103 ENST00000454919 ENST00000396144 ENST00000375245
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP12 (see all 40):
    hsa-miR-106a hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP12 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP12
      QuantiFast Probe-based Assays in human, mouse, rat ARHGAP12

    Additional mRNA sequence: 

    AF131804.1 AK000744.1 AK001833.1 AK025438.1 AK091182.1 AK127611.1 AK315066.1 AL137485.1 
    AL834250.2 AY033594.1 AY033595.1 BC051811.1 BC094719.1 BC115362.2 BC115363.2 CR936681.1 

    18 DOTS entries:

    DT.97844551  DT.100026780  DT.101983907  DT.113603  DT.100786091  DT.101983908  DT.100786095  DT.100786089 
    DT.121255549  DT.100786087  DT.121255592  DT.437344  DT.102826405  DT.113602  DT.121255534  DT.97831310 
    DT.427781  DT.75192650 

    Selected AceView cDNA sequences (see all 182):

    AY033595 BQ006442 BC051811 Z43322 BM975446 CB068530 BU509814 AL712774 
    BP338326 BM718700 Z39397 H44459 BM983613 BX112981 NM_018287 AA280616 
    BX952225 AF131804 AU118191 CD676922 CR613881 AK000744 AY033594 AL137485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP12 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                                                                          -                                         -                 -                     
    SP2:                                                                    -     -                                         -                 -                     
    SP3:                                                  -                       -                                         -                 -                     
    SP4:              -     -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b · 21c
    SP1:  -                     
    SP2:  -                     
    SP3:  -                     
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ARHGAP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTCTAA
    ARHGAP12 Expression
    About this image


    ARHGAP12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Endochondral Facial Bones
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Eye (Sensory Organs)
             Retina
    ARHGAP12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499264
        Custom PCR Arrays for ARHGAP12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP12 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap121 , 5 Rho GTPase activating protein 121, 5 89.06(n)1
    91.53(a)1
      18 (4.46 cM)5
    754151  NM_001039692.11  NP_001034781.11 
     60244275 
    chicken
    (Gallus gallus)
    Aves ARHGAP121 Rho GTPase activating protein 12 78.61(n)
    83.51(a)
      420473  XM_418575.4  XP_418575.4 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP126
    Rho GTPase activating protein 12
    77(a)
    1 ↔ 1
    6(12645221-12708452)
    African clawed frog
    (Xenopus laevis)
    Amphibia arhgap12-prov2 Rho GTPase activating protein 12 76.71(n)    BC046844.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732392 hypothetical protein MGC73239 74.8(n)   393848  BC063321.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3256
    Protein TAG-325 (tag-325) mRNA, complete cds
    20(a)
    1 → many
    III(4796841-4802910) WBGene00008006


    ENSEMBL Gene Tree for ARHGAP12 (if available)
    TreeFam Gene Tree for ARHGAP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP12 gene
    ARHGAP212  ARHGAP272  ARHGAP102  CHN22  ARHGAP232  ARHGAP92  CHN12  ARHGAP262  
    ARHGAP152  OPHN12  ARHGAP422  
    Selected SIMAP similar genes for ARHGAP12 using alignment to 6 protein entries:     RHG12_HUMAN (see all proteins) (see all similar genes):
    ARHGAP15    OPHN1    ARHGAP10    DKFZp667D142    ARHGAP17    ARHGAP18
    ARHGAP42    MYO9B    MYO9B variant protein    CHN1    CHN2    ARHGAP27
    ARHGAP9    ARHGAP1    ARHGAP44    BCR    ARHGAP31    ARHGAP26

    Find genes that share paralogs with ARHGAP12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP12 (see all 2575)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605320231,2
    C--32071850(+) AAAAA-/A/AA  
      A
    /AAAA
    CAGAA
    6 -- int11NA 2
    rs1162364281,2
    F--32093904(+) CACTGC/TTATCT 6 -- ds50011Minor allele frequency- T:0.13WA 118
    rs1905354731,2
    --32093973(+) GGTCTC/TCATGT 6 -- ds50010--------
    rs1122469821,2
    C--32093979(+) CATGTA/GTCTGC 6 -- ds50012Minor allele frequency- G:0.04NA 122
    rs79054711,2
    C,F,H--32094004(+) TTCACT/CTGTAT 6 -- ds500112Minor allele frequency- C:0.16NS EA NA CSA WA 922
    rs1818264521,2
    --32094264(+) TGTTTC/TTCTTC 6 -- ds50010--------
    rs1409706151,2
    --32094302(+) TATACC/TTTCTT 6 -- ds50010--------
    rs1854088011,2
    --32094334(+) TTTCAA/GTGACA 6 -- ut310--------
    rs1447807621,2
    --32094401(+) TAATAC/TATTTT 6 -- ut310--------
    rs110086521,2
    C,F,H--32094413(+) TACTAT/CAAAAC 6 -- ut31 ese312Minor allele frequency- C:0.12NS EA WA NA 1314

    HapMap Linkage Disequilibrium report for ARHGAP12 (32094365 - 32217770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGAP12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659410CNV Deletion23128226
    esv274256CNV Insertion20981092
    esv271395CNV Insertion20981092
    nsv24963CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP12
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610577    OMIM disorders: --


    Find genes that share disorders with ARHGAP12           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP12
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP12 (2 documents)

    Export disorders for ARHGAP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP12 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ARHGAP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning and characterization of ARHGAP12, a novel human rhoGAP gene. (PubMed id 11854031)1, 3 Zhang Z....Mao Y. (amp 2002)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94134 HGNC: 16348 AceView: ARHGAP12 Ensembl:ENSG00000165322 euGenes: HUgn94134
    ECgene: ARHGAP12 H-InvDB: ARHGAP12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP12 gene:
    Search GeneIP for patents involving ARHGAP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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