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Aliases for ARHGAP11B Gene

Aliases for ARHGAP11B Gene

  • Rho GTPase Activating Protein 11B 2 3 5
  • Family With Sequence Similarity 7, Member B1 2 3
  • Rho-Type GTPase-Activating Protein 11B 3 4
  • GAP (1-8) 2 3
  • FAM7B1 3 4
  • Protein FAM7B1 4
  • B-T 3

External Ids for ARHGAP11B Gene

Previous HGNC Symbols for ARHGAP11B Gene

  • FAM7B1

Previous GeneCards Identifiers for ARHGAP11B Gene

  • GC00U917803
  • GC15P028707
  • GC15P030918
  • GC15P008099
  • GC15P030921

Summaries for ARHGAP11B Gene

GeneCards Summary for ARHGAP11B Gene

ARHGAP11B (Rho GTPase Activating Protein 11B) is a Protein Coding gene. Diseases associated with ARHGAP11B include Chromosome 15Q13.3 Microdeletion Syndrome. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP11B Gene

  • Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11B Gene

Genomics for ARHGAP11B Gene

Regulatory Elements for ARHGAP11B Gene

Enhancers for ARHGAP11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP11B on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP11B on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP11B Gene

30,624,494 bp from pter
30,772,993 bp from pter
148,500 bases
Plus strand

Genomic View for ARHGAP11B Gene

Genes around ARHGAP11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11B Gene

Proteins for ARHGAP11B Gene

  • Protein details for ARHGAP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 11B
    Protein Accession:

    Protein attributes for ARHGAP11B Gene

    267 amino acids
    Molecular mass:
    30251 Da
    Quaternary structure:
    No Data Available
    • ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.
    • When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.

neXtProt entry for ARHGAP11B Gene

Proteomics data for ARHGAP11B Gene at MOPED

Post-translational modifications for ARHGAP11B Gene

No Post-translational modifications

Other Protein References for ARHGAP11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP11B Gene

Domains & Families for ARHGAP11B Gene

Gene Families for ARHGAP11B Gene

Protein Domains for ARHGAP11B Gene

Suggested Antigen Peptide Sequences for ARHGAP11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP11B: view

Function for ARHGAP11B Gene

Molecular function for ARHGAP11B Gene

UniProtKB/Swiss-Prot Function:
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP11B Gene

Localization for ARHGAP11B Gene

Subcellular locations from

Jensen Localization Image for ARHGAP11B Gene COMPARTMENTS Subcellular localization image for ARHGAP11B gene
Compartment Confidence
cytosol 5
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP11B Gene

Pathways & Interactions for ARHGAP11B Gene

genes like me logo Genes that share pathways with ARHGAP11B: view

Pathways by source for ARHGAP11B Gene

3 Reactome pathways for ARHGAP11B Gene

Interacting Proteins for ARHGAP11B Gene

Gene Ontology (GO) - Biological Process for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0021987 cerebral cortex development IDA 25721503
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

No data available for SIGNOR curated interactions for ARHGAP11B Gene

Drugs & Compounds for ARHGAP11B Gene

No Compound Related Data Available

Transcripts for ARHGAP11B Gene

mRNA/cDNA for ARHGAP11B Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP11B Gene

Rho GTPase activating protein 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11B Gene

No ASD Table

Relevant External Links for ARHGAP11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP11B Gene

mRNA expression in normal human tissues for ARHGAP11B Gene

SOURCE GeneReport for Unigene cluster for ARHGAP11B Gene Hs.659621

genes like me logo Genes that share expression patterns with ARHGAP11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARHGAP11B Gene

Orthologs for ARHGAP11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP11B 36
  • 21 (a)
(Canis familiaris)
Mammalia ARHGAP11B 36
  • 20 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 14 (a)
-- 36
  • 2 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Gallus gallus)
Aves ARHGAP11A 36
  • 7 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
(Danio rerio)
Actinopterygii arhgap11a 36
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta cv-c 36
  • 2 (a)
(Caenorhabditis elegans)
Secernentea gei-1 36
  • 3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 6 (a)
Species with no ortholog for ARHGAP11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11B Gene

Gene Tree for ARHGAP11B (if available)
Gene Tree for ARHGAP11B (if available)

Paralogs for ARHGAP11B Gene

(1) SIMAP similar genes for ARHGAP11B Gene using alignment to 1 proteins: Pseudogenes for ARHGAP11B Gene

genes like me logo Genes that share paralogs with ARHGAP11B: view

Variants for ARHGAP11B Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs14618 -- 30,635,131(-) AGATT(C/T)GGTGC reference, synonymous-codon
rs14619 -- 30,635,177(-) TTCTG(C/T)GTTAG reference, missense
rs1574382 -- 30,634,565(+) TACTC(C/T)AATTT intron-variant
rs12904496 -- 30,628,354(+) gggat(G/T)gcagg intron-variant
rs59576708 -- 30,638,924(+) AGTTT(A/T)ATCAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11B Gene

Variant ID Type Subtype PubMed ID
esv2751526 CNV Loss 17911159
dgv716e1 CNV Complex 17122850
nsv428300 CNV Loss 18775914
dgv717e1 CNV Complex 17122850
nsv518720 CNV Gain 19592680
nsv903757 CNV Gain 21882294
nsv9232 CNV Gain+Loss 18304495
dgv718e1 CNV Complex 17122850
dgv720e1 CNV Complex 17122850
dgv721e1 CNV Complex 17122850
dgv722e1 CNV Complex 17122850
esv24159 CNV Gain+Loss 19812545
nsv903821 CNV Loss 21882294
esv2749524 CNV Deletion 23290073
nsv903822 CNV Gain 21882294
nsv832949 CNV Gain 17160897
nsv903823 CNV Loss 21882294
dgv2306n71 CNV Gain 21882294
esv2421741 CNV Deletion 20811451
dgv431n67 CNV Loss 20364138
esv1523587 CNV Insertion 17803354
essv2950 CNV CNV 17122850

Variation tolerance for ARHGAP11B Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGAP11B Gene

Disorders for ARHGAP11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP11B Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 microdeletion syndrome
  • 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP11B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGAP11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP11B Gene

Publications for ARHGAP11B Gene

  1. Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. (PMID: 25721503) Florio M. … Huttner W.B. (Science 2015) 2 3 4 67
  2. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 3
  3. A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (PMID: 23962720) Speed D. … Johnson M.R. (Hum. Mol. Genet. 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3

Products for ARHGAP11B Gene

Sources for ARHGAP11B Gene