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Aliases for ARHGAP11B Gene

Aliases for ARHGAP11B Gene

  • Rho GTPase Activating Protein 11B 2 3
  • Family With Sequence Similarity 7, Member B1 2 3
  • Rho-Type GTPase-Activating Protein 11B 3 4
  • GAP (1-8) 2 3
  • Rho GTPase-Activating Protein 11B 3
  • FAM7B1 3
  • B-T 3

External Ids for ARHGAP11B Gene

Previous HGNC Symbols for ARHGAP11B Gene

  • FAM7B1

Previous GeneCards Identifiers for ARHGAP11B Gene

  • GC00U917803
  • GC15P028707
  • GC15P030918
  • GC15P008099
  • GC15P030921

Summaries for ARHGAP11B Gene

GeneCards Summary for ARHGAP11B Gene

ARHGAP11B (Rho GTPase Activating Protein 11B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP11B Gene

  • Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11B Gene

Genomics for ARHGAP11B Gene

Regulatory Elements for ARHGAP11B Gene

Genomic Location for ARHGAP11B Gene

Start:
30,624,494 bp from pter
End:
30,772,993 bp from pter
Size:
148,500 bases
Orientation:
Plus strand

Genomic View for ARHGAP11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11B Gene

Proteins for ARHGAP11B Gene

  • Protein details for ARHGAP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRB8-RHGBB_HUMAN
    Recommended name:
    Rho GTPase-activating protein 11B
    Protein Accession:
    Q3KRB8
    Secondary Accessions:

    Protein attributes for ARHGAP11B Gene

    Size:
    267 amino acids
    Molecular mass:
    30251 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.
    • When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.

neXtProt entry for ARHGAP11B Gene

Proteomics data for ARHGAP11B Gene at MOPED

Post-translational modifications for ARHGAP11B Gene

No Post-translational modifications

Other Protein References for ARHGAP11B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP11B Gene

Domains for ARHGAP11B Gene

Gene Families for ARHGAP11B Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP11B Gene

Suggested Antigen Peptide Sequences for ARHGAP11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRB8

UniProtKB/Swiss-Prot:

RHGBB_HUMAN :
  • Q3KRB8
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP11B: view

Function for ARHGAP11B Gene

Molecular function for ARHGAP11B Gene

UniProtKB/Swiss-Prot Function: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

Gene Ontology (GO) - Molecular Function for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 NOT GTPase activator activity IDA 25721503
genes like me logo Genes that share ontologies with ARHGAP11B: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ARHGAP11B
    • Block miRNA regulation of ARHGAP11B using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP11B

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP11B Gene

    Localization for ARHGAP11B Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for ARHGAP11B Gene COMPARTMENTS Subcellular localization image for ARHGAP11B gene
    Compartment Confidence
    cytosol 4
    golgi apparatus 1
    mitochondrion 1
    nucleus 1
    peroxisome 1
    plasma membrane 1

    Gene Ontology (GO) - Cellular Components for ARHGAP11B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005622 intracellular --
    GO:0005829 cytosol TAS --
    genes like me logo Genes that share ontologies with ARHGAP11B: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP11B Gene

    Pathways for ARHGAP11B Gene

    genes like me logo Genes that share pathways with ARHGAP11B: view

    Pathways by source for ARHGAP11B Gene

    3 Reactome pathways for ARHGAP11B Gene

    Interacting Proteins for ARHGAP11B Gene

    Gene Ontology (GO) - Biological Process for ARHGAP11B Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0007165 signal transduction --
    GO:0007264 small GTPase mediated signal transduction TAS --
    GO:0021987 cerebral cortex development IDA 25721503
    GO:0043547 positive regulation of GTPase activity --
    GO:0051056 regulation of small GTPase mediated signal transduction TAS --
    genes like me logo Genes that share ontologies with ARHGAP11B: view

    Transcripts for ARHGAP11B Gene

    mRNA/cDNA for ARHGAP11B Gene

    (7) REFSEQ mRNAs :
    (3) Additional mRNA sequences :
    (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for ARHGAP11B Gene

    Rho GTPase activating protein 11B:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate ARHGAP11B
      • Block miRNA regulation of ARHGAP11B using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP11B

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGAP11B
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11B Gene

      No ASD Table

      Relevant External Links for ARHGAP11B Gene

      GeneLoc Exon Structure for
      ARHGAP11B
      ECgene alternative splicing isoforms for
      ARHGAP11B

      Expression for ARHGAP11B Gene

      mRNA expression in normal human tissues for ARHGAP11B Gene

      SOURCE GeneReport for Unigene cluster for ARHGAP11B Gene Hs.659621

      genes like me logo Genes that share expressions with ARHGAP11B: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ARHGAP11B Gene

      Orthologs for ARHGAP11B Gene

      This gene was present in the common ancestor of animals and fungi.

      Orthologs for ARHGAP11B Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia ARHGAP11B 36
      • 21 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia ARHGAP11B 36
      • 20 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia -- 36
      • 14 (a)
      ManyToMany
      -- 36
      • 2 (a)
      ManyToMany
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 54 (a)
      OneToMany
      chicken
      (Gallus gallus)
      Aves ARHGAP11A 36
      • 7 (a)
      OneToMany
      lizard
      (Anolis carolinensis)
      Reptilia -- 36
      • 15 (a)
      OneToMany
      zebrafish
      (Danio rerio)
      Actinopterygii arhgap11a 36
      • 15 (a)
      OneToMany
      fruit fly
      (Drosophila melanogaster)
      Insecta cv-c 36
      • 2 (a)
      OneToMany
      worm
      (Caenorhabditis elegans)
      Secernentea gei-1 36
      • 3 (a)
      OneToMany
      baker's yeast
      (Saccharomyces cerevisiae)
      Saccharomycetes LRG1 36
      • 6 (a)
      OneToMany
      Species with no ortholog for ARHGAP11B:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chimpanzee (Pan troglodytes)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • mouse (Mus musculus)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)

      Evolution for ARHGAP11B Gene

      ENSEMBL:
      Gene Tree for ARHGAP11B (if available)
      TreeFam:
      Gene Tree for ARHGAP11B (if available)

      Paralogs for ARHGAP11B Gene

      Selected SIMAP similar genes for ARHGAP11B Gene using alignment to 1 proteins:

      Pseudogenes.org Pseudogenes for ARHGAP11B Gene

      genes like me logo Genes that share paralogs with ARHGAP11B: view

      Variants for ARHGAP11B Gene

      Sequence variations from dbSNP and Humsavar for ARHGAP11B Gene

      SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
      rs14618 -- 30,635,131(-) AGATT(C/T)GGTGC reference, synonymous-codon
      rs14619 -- 30,635,177(-) TTCTG(C/T)GTTAG missense, reference
      rs1574382 -- 30,634,565(+) TACTC(C/T)AATTT intron-variant
      rs8024735 -- 30,638,046(+) aactc(C/T)ggaca intron-variant
      rs8027951 -- 30,638,297(+) CAAAC(G/T)GTGTT intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11B Gene

      Variant ID Type Subtype PubMed ID
      esv2751526 CNV Loss 17911159
      dgv716e1 CNV Complex 17122850
      nsv428300 CNV Loss 18775914
      dgv717e1 CNV Complex 17122850
      nsv518720 CNV Gain 19592680
      nsv903757 CNV Gain 21882294
      nsv9232 CNV Gain+Loss 18304495
      dgv718e1 CNV Complex 17122850
      dgv720e1 CNV Complex 17122850
      dgv721e1 CNV Complex 17122850
      dgv722e1 CNV Complex 17122850
      esv24159 CNV Gain+Loss 19812545
      nsv903821 CNV Loss 21882294
      esv2749524 CNV Deletion 23290073
      nsv903822 CNV Gain 21882294
      nsv832949 CNV Gain 17160897
      nsv903823 CNV Loss 21882294
      dgv2306n71 CNV Gain 21882294
      esv2421741 CNV Deletion 20811451
      dgv431n67 CNV Loss 20364138
      esv1523587 CNV Insertion 17803354
      essv2950 CNV CNV 17122850

      Relevant External Links for ARHGAP11B Gene

      HapMap Linkage Disequilibrium report
      ARHGAP11B

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11B Gene

      Disorders for ARHGAP11B Gene

      Relevant External Links for ARHGAP11B

      Genetic Association Database (GAD)
      ARHGAP11B
      genes like me logo Genes that share disorders with ARHGAP11B: view

      No data available for UniProtKB/Swiss-Prot for ARHGAP11B Gene

      Publications for ARHGAP11B Gene

      1. Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. (PMID: 25721503) Florio M. … Huttner W.B. (Science 2015) 2 3 4
      2. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 3
      3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
      4. A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (PMID: 23962720) Speed D. … Johnson M.R. (Hum. Mol. Genet. 2014) 3
      5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

      Products for ARHGAP11B Gene

      Sources for ARHGAP11B Gene

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