ARHGAP11B Gene
protein-coding GIFtS: 38
GCID: GC15P030918
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Rho GTPase activating protein 11B(Previous names: family with sequence similarity 7, member B1 )
(Previous symbol: FAM7B1)
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Aliases
for ARHGAP11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GTPase Activating Protein 11B1 2 | | Rho-Type GTPase-Activating Protein 11B2 3 | | B'-T1 2 | | GAP (1-8)2 | | FAM7B11 2 | | Rho GTPase-Activating Protein 11B2 | | Family With Sequence Similarity 7, Member B11 2 | | |
Export aliases for ARHGAP11B gene to outside databasesPrevious GC identifers: GC00U917803 GC15P028707 GC15P008099 |
Summaries
for ARHGAP11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ARHGAP11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGAP11B gene promoter:
C/EBPbeta AML1a Nkx2-2 ATF-2 LCR-F1 PPAR-alpha POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGAP11B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP11B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13.2 Ensembl cytogenetic band: 15q13.2 HGNC cytogenetic band: 15q13.2ARHGAP11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P030918: view genomic region
(about GC identifiers)
Start:
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30,916,697 bp from pter |
End:
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31,060,329 bp from pter |
Size:
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143,633 bases |
Orientation:
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plus strand |
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Proteins
for ARHGAP11B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHGBB_HUMAN, Q3KRB8 (See
protein sequence)Recommended Name: Rho GTPase-activating protein 11B Size: 267 amino acids; 30251 DaExplore the universe of human proteins at neXtProt for ARHGAP11B: NX_Q3KRB8
ARHGAP11B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034930.1
ENSEMBL proteins: ENSP00000457054 ENSP00000392760 Reactome Protein details: Q3KRB8
Human Recombinant Protein Products for ARHGAP11B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
ARHGAP11B for ontologies About GeneDecksing
ARHGAP11B Antibody Products:
Assay Products for ARHGAP11B: |
Protein
Domains /
Families
for ARHGAP11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGAP11B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3KRB8ProtoNet protein and cluster: Q3KRB8 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: RHGBB_HUMAN, Q3KRB8Similarity: Contains 1 Rho-GAP domain |
Function
for ARHGAP11B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- |
ARHGAP11B for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGAP11B (NM_001039841) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP11B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP11B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP11B |
|
Pathways & Interactions
for ARHGAP11B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for ARHGAP11B
ARHGAP11B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP11B
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
ARHGAP11B for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGAP11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGAP11B
Search CenterWatch for drugs/clinical trials and news about ARHGAP11B / RHGBB
|
Transcripts
for ARHGAP11B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGAP11B gene: NM_001039841.1 Unigene Cluster for ARHGAP11B: Rho GTPase activating protein 11B Hs.659621 [show with all ESTs]Unigene Representative Sequence: BC0719909 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000567449(uc010azu.1) ENST00000564902(uc010azv.1) ENST00000563110(uc001zet.1 uc001zeu.3)
ENST00000428041 ENST00000566362 ENST00000568574 ENST00000566548 ENST00000569416
ENST00000562954(uc001zev.3 uc021sht.1 uc021shu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGAP11B (NM_001039841) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP11B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP11B |
Additional cDNA sequence: AK310319.1 BC071990.1 BC105788.1 7 DOTS entries: DT.102832216 DT.40282285 DT.121033551 DT.40128946 DT.121033548 DT.85104163 DT.95375483
GeneLoc Exon Structure
|
Expression
for ARHGAP11B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGAP11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGATGTC
About this image
See ARHGAP11B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.659621
SABiosciences Custom PCR Arrays for ARHGAP11B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP11B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ARHGAP11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP11B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP11B |
Orthologs
for ARHGAP11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP11B gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for ARHGAP11B (if available)
TreeFam Gene Tree for ARHGAP11B (if available) |
Paralogs
for ARHGAP11B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGAP11B gene
- ARHGAP362 ARHGAP62 STARD132 ARHGAP402 ARHGAP182 ARHGAP11A2 DLC12 ARHGAP282
- STARD82
1 SIMAP similar gene for ARHGAP11B using alignment to 1 protein entry: RHGBB_HUMAN:ARHGAP11A
ARHGAP11B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ARHGAP11B
PGOHUM00000258954
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Genomic Variants
for ARHGAP11B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGAP11B (30916697 - 31060329 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ARHGAP11B
9 CNVs: 66761 4887 3955 87581 3074 32014 9262 87582 66762
1 Inversion: 37164 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP11B |
|
Disorders
/ Diseases
for ARHGAP11B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGAP11B for disorders About GeneDecksing
1  disease for ARHGAP11B: About MalaCardsexophthalmos
Export disorders for ARHGAP11B gene to outside databases
|
Publications
for ARHGAP11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGAP11B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGAP11B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)1, 3 Riley B.... Makoff A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
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External Searches for ARHGAP11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ARHGAP11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGAP11B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGAP11B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGAP11B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGAP11B gene:
Search GeneIP for patents involving ARHGAP11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGAP11B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGAP11B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGAP11B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGAP11B | | | OriGene Protein Over-expression Lysate for ARHGAP11B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGAP11B | | OriGene 3'-UTR Clone for ARHGAP11B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGAP11B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP11B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGAP11B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP11B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP11B |
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 | | | ARHGAP11B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP11B |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP11B |
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