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Aliases for ARHGAP11B Gene

Aliases for ARHGAP11B Gene

  • Rho GTPase Activating Protein 11B 2 3
  • Family With Sequence Similarity 7, Member B1 2 3
  • Rho-Type GTPase-Activating Protein 11B 3 4
  • GAP (1-8) 2 3
  • Rho GTPase-Activating Protein 11B 3
  • FAM7B1 3
  • B-T 3

External Ids for ARHGAP11B Gene

Previous Symbols for ARHGAP11B Gene

  • FAM7B1

Summaries for ARHGAP11B Gene

GeneCards Summary for ARHGAP11B Gene

ARHGAP11B (Rho GTPase Activating Protein 11B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP11B Gene

  • Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11B Gene

Genomics for ARHGAP11B Gene

Genomic Location for ARHGAP11B Gene

Start:
30,624,494 bp from pter
End:
30,772,993 bp from pter
Size:
148,500 bases
Orientation:
Plus strand

Genomic View for ARHGAP11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11B Gene

Regulatory Elements for ARHGAP11B Gene

Proteins for ARHGAP11B Gene

  • Protein details for ARHGAP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRB8-RHGBB_HUMAN
    Recommended name:
    Rho GTPase-activating protein 11B
    Protein Accession:
    Q3KRB8
    Secondary Accessions:

    Protein attributes for ARHGAP11B Gene

    Size:
    267 amino acids
    Molecular mass:
    30251 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.
    • When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.

neXtProt entry for ARHGAP11B Gene

Proteomics data for ARHGAP11B Gene at MOPED

Post-translational modifications for ARHGAP11B Gene

No Post-translational modifications

Other Protein References for ARHGAP11B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP11B Gene

Domains for ARHGAP11B Gene

Gene Families for ARHGAP11B Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP11B Gene

Suggested Antigen Peptide Sequences for ARHGAP11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRB8

UniProtKB/Swiss-Prot:

RHGBB_HUMAN
Domain:
  • Contains 1 Rho-GAP domain.:
    • Q3KRB8
genes like me logo Genes that share domains with ARHGAP11B: view

Function for ARHGAP11B Gene

Molecular function for ARHGAP11B Gene

UniProtKB/Swiss-Prot Function: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not posses GTPase activator activity (PubMed:25721503).

Gene Ontology (GO) - Molecular Function for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 NOT GTPase activator activity IDA 25721503
genes like me logo Genes that share ontologies with ARHGAP11B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP11B Gene

Localization for ARHGAP11B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP11B Gene COMPARTMENTS Subcellular localization image for ARHGAP11B gene
Compartment Confidence
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP11B Gene

Pathways for ARHGAP11B Gene

genes like me logo Genes that share pathways with ARHGAP11B: view

Pathways by source for ARHGAP11B Gene

3 Reactome pathways for ARHGAP11B Gene

Interacting Proteins for ARHGAP11B Gene

Gene Ontology (GO) - Biological Process for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0021987 cerebral cortex development IDA 25721503
GO:0043547 positive regulation of GTPase activity --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

Transcripts for ARHGAP11B Gene

mRNA/cDNA for ARHGAP11B Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP11B Gene

Rho GTPase activating protein 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11B Gene

No ASD Table

Relevant External Links for ARHGAP11B Gene

GeneLoc Exon Structure for
ARHGAP11B
ECgene alternative splicing isoforms for
ARHGAP11B

Expression for ARHGAP11B Gene

mRNA expression in normal human tissues for ARHGAP11B Gene

SOURCE GeneReport for Unigene cluster for ARHGAP11B Gene Hs.659621

genes like me logo Genes that share expressions with ARHGAP11B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ARHGAP11B Gene

Orthologs for ARHGAP11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP11B 36
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP11B 36
  • 20 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 14 (a)
ManyToMany
-- 36
  • 2 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP11A 36
  • 7 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii arhgap11a 36
  • 15 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cv-c 36
  • 2 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-1 36
  • 3 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 6 (a)
OneToMany
Species with no ortholog for ARHGAP11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11B Gene

ENSEMBL:
Gene Tree for ARHGAP11B (if available)
TreeFam:
Gene Tree for ARHGAP11B (if available)

Paralogs for ARHGAP11B Gene

Selected SIMAP similar genes for ARHGAP11B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARHGAP11B Gene

genes like me logo Genes that share paralogs with ARHGAP11B: view

Variants for ARHGAP11B Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14618 -- 30,635,131(-) AGATT(C/T)GGTGC reference, synonymous-codon
rs14619 -- 30,635,177(-) TTCTG(C/T)GTTAG missense, reference
rs1574382 -- 30,634,565(+) TACTC(C/T)AATTT intron-variant
rs8024735 -- 30,638,046(+) aactc(C/T)ggaca intron-variant
rs8027951 -- 30,638,297(+) CAAAC(G/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11B Gene

Variant ID Type Subtype PubMed ID
esv2751526 CNV Loss 17911159
dgv716e1 CNV Complex 17122850
nsv428300 CNV Loss 18775914
dgv717e1 CNV Complex 17122850
nsv518720 CNV Gain 19592680
nsv903757 CNV Gain 21882294
nsv9232 CNV Gain+Loss 18304495
dgv718e1 CNV Complex 17122850
dgv720e1 CNV Complex 17122850
dgv721e1 CNV Complex 17122850
dgv722e1 CNV Complex 17122850
esv24159 CNV Gain+Loss 19812545
nsv903821 CNV Loss 21882294
esv2749524 CNV Deletion 23290073
nsv903822 CNV Gain 21882294
nsv832949 CNV Gain 17160897
nsv903823 CNV Loss 21882294
dgv2306n71 CNV Gain 21882294
esv2421741 CNV Deletion 20811451
dgv431n67 CNV Loss 20364138
esv1523587 CNV Insertion 17803354
essv2950 CNV CNV 17122850

Relevant External Links for ARHGAP11B Gene

HapMap Linkage Disequilibrium report
ARHGAP11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11B Gene

Disorders for ARHGAP11B Gene

Relevant External Links for ARHGAP11B

Genetic Association Database (GAD)
ARHGAP11B
genes like me logo Genes that share disorders with ARHGAP11B: view

No data available for UniProtKB/Swiss-Prot for ARHGAP11B Gene

Publications for ARHGAP11B Gene

  1. Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. (PMID: 25721503) Florio M. … Huttner W.B. (Science 2015) 2 3 4
  2. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (PMID: 23962720) Speed D. … Johnson M.R. (Hum. Mol. Genet. 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ARHGAP11B Gene

Sources for ARHGAP11B Gene

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