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Aliases for ARHGAP11A Gene

Aliases for ARHGAP11A Gene

  • Rho GTPase Activating Protein 11A 2 3 5
  • Rho-Type GTPase-Activating Protein 11A 4
  • GAP (1-12) 2
  • KIAA0013 4

External Ids for ARHGAP11A Gene

Previous GeneCards Identifiers for ARHGAP11A Gene

  • GC15P028150
  • GC15P025615
  • GC15P030486
  • GC15P030623
  • GC15P030694
  • GC15P032907
  • GC15P009778

Summaries for ARHGAP11A Gene

GeneCards Summary for ARHGAP11A Gene

ARHGAP11A (Rho GTPase Activating Protein 11A) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11A Gene

Genomics for ARHGAP11A Gene

Regulatory Elements for ARHGAP11A Gene

Enhancers for ARHGAP11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP11A on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP11A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP11A Gene

Chromosome:
15
Start:
32,613,733 bp from pter
End:
32,639,949 bp from pter
Size:
26,217 bases
Orientation:
Plus strand

Genomic View for ARHGAP11A Gene

Genes around ARHGAP11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11A Gene

Proteins for ARHGAP11A Gene

  • Protein details for ARHGAP11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F7-RHGBA_HUMAN
    Recommended name:
    Rho GTPase-activating protein 11A
    Protein Accession:
    Q6P4F7
    Secondary Accessions:
    • B4DZN9
    • Q6PI96
    • Q9Y3S6

    Protein attributes for ARHGAP11A Gene

    Size:
    1023 amino acids
    Molecular mass:
    113866 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP11A Gene

    Alternative splice isoforms for ARHGAP11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP11A Gene

Proteomics data for ARHGAP11A Gene at MOPED

Post-translational modifications for ARHGAP11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP11A Gene

Domains & Families for ARHGAP11A Gene

Gene Families for ARHGAP11A Gene

Protein Domains for ARHGAP11A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4F7

UniProtKB/Swiss-Prot:

RHGBA_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP11A: view

Function for ARHGAP11A Gene

Phenotypes for ARHGAP11A Gene

genes like me logo Genes that share phenotypes with ARHGAP11A: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP11A Gene

Localization for ARHGAP11A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP11A Gene COMPARTMENTS Subcellular localization image for ARHGAP11A gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGAP11A Gene

Pathways & Interactions for ARHGAP11A Gene

genes like me logo Genes that share pathways with ARHGAP11A: view

Pathways by source for ARHGAP11A Gene

3 Reactome pathways for ARHGAP11A Gene

Interacting Proteins for ARHGAP11A Gene

Gene Ontology (GO) - Biological Process for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11A: view

No data available for SIGNOR curated interactions for ARHGAP11A Gene

Drugs & Compounds for ARHGAP11A Gene

No Compound Related Data Available

Transcripts for ARHGAP11A Gene

Unigene Clusters for ARHGAP11A Gene

Rho GTPase activating protein 11A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11A Gene

No ASD Table

Relevant External Links for ARHGAP11A Gene

GeneLoc Exon Structure for
ARHGAP11A
ECgene alternative splicing isoforms for
ARHGAP11A

Expression for ARHGAP11A Gene

mRNA expression in normal human tissues for ARHGAP11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP11A Gene

This gene is overexpressed in Cerebrospinal fluid (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP11A Gene



SOURCE GeneReport for Unigene cluster for ARHGAP11A Gene Hs.591130

genes like me logo Genes that share expression patterns with ARHGAP11A: view

Protein tissue co-expression partners for ARHGAP11A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP11A Gene

Orthologs for ARHGAP11A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP11A 35
  • 85.27 (n)
  • 77.21 (a)
dog
(Canis familiaris)
Mammalia ARHGAP11A 35
  • 84.99 (n)
  • 76.7 (a)
mouse
(Mus musculus)
Mammalia Arhgap11a 35
  • 78.62 (n)
  • 71.44 (a)
Arhgap11a 16
Arhgap11a 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP11A 35
  • 99.54 (n)
  • 99.32 (a)
ARHGAP11A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap11a 35
  • 79.31 (n)
  • 71.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP11A 35
  • 62.03 (n)
  • 52.66 (a)
ARHGAP11A 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap11a.1 35
  • 55.18 (n)
  • 46.21 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap11a 35
  • 56.51 (n)
  • 51 (a)
wufc55g06 35
arhgap11a 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cv-c 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-1 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 8 (a)
OneToMany
Species with no ortholog for ARHGAP11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11A Gene

ENSEMBL:
Gene Tree for ARHGAP11A (if available)
TreeFam:
Gene Tree for ARHGAP11A (if available)

Paralogs for ARHGAP11A Gene

(2) SIMAP similar genes for ARHGAP11A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP11A Gene

genes like me logo Genes that share paralogs with ARHGAP11A: view

Variants for ARHGAP11A Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_035546 A breast cancer sample
rs4993234 -- 32,618,313(+) ATATA(A/G)CAGAA intron-variant
rs4993239 -- 32,618,058(+) AATCA(C/T)GCCAT intron-variant
rs11857729 -- 32,633,864(+) TTCAA(A/C)TTTCG intron-variant
rs12438775 -- 32,629,151(-) ATTAG(A/C/G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11A Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
nsv517740 CNV Gain+Loss 19592680
dgv728e1 CNV Complex 17122850
dgv2318n71 CNV Loss 21882294
nsv903959 CNV Gain 21882294
dgv729e1 CNV Complex 17122850
esv2422296 CNV Duplication 17116639
nsv469587 CNV Loss 16826518
nsv483039 CNV Gain 15286789
esv21965 CNV Gain+Loss 19812545
nsv9239 CNV Loss 18304495
nsv456785 CNV Gain 19166990
nsv1481 CNV Loss 18451855

Variation tolerance for ARHGAP11A Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP11A Gene

HapMap Linkage Disequilibrium report
ARHGAP11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11A Gene

Disorders for ARHGAP11A Gene

Relevant External Links for ARHGAP11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP11A

No disorders were found for ARHGAP11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP11A Gene

Publications for ARHGAP11A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ARHGAP11A Gene

Sources for ARHGAP11A Gene

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