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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP11A Gene

protein-coding   GIFtS: 51
GCID: GC15P032907

Rho GTPase activating protein 11A
  Search for ARHGAP11A
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGAP11A    

Aliases
for ARHGAP11A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho GTPase Activating Protein 11A1 2
KIAA00131 3 5
Rho-Type GTPase-Activating Protein 11A2 3
GAP (1-12)2
Rho GTPase-Activating Protein 11A2

External Ids:    HGNC: 157831   Entrez Gene: 98242   Ensembl: ENSG000001988267   OMIM: 6105895   UniProtKB: Q6P4F73   

Export aliases for ARHGAP11A gene to outside databases

Previous GC identifers: GC15P028150 GC15P025615 GC15P030486 GC15P030623 GC15P030694 GC15P009778


Summaries
for ARHGAP11A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ARHGAP11A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP11A gene promoter:
         C/EBPbeta   AML1a   FOXJ2 (long isoform)   Nkx2-2   ATF-2   Olf-1   FOXJ2   c-Jun   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGAP11A promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.2   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13.3

ARHGAP11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP11A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032907:  view genomic region     (about GC identifiers)

Start:
 32,907,345 bp from pter      End:
 32,932,150 bp from pter
Size:
 24,806 bases      Orientation:
 plus strand

Proteins
for ARHGAP11A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHGBA_HUMAN, Q6P4F7 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 11A  
Size: 1023 amino acids; 113866 Da
Sequence caution: Sequence=BAA13442.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ARHGAP11A:
3EAP (3D)    
Secondary accessions: Q6PI96 Q9Y3S6

Explore the universe of human proteins at neXtProt for ARHGAP11A: NX_Q6P4F7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P4F7

    • ARHGAP11A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055598.1  NP_955389.1  

    ENSEMBL proteins: 
     ENSP00000455754   ENSP00000355090   ENSP00000454575   ENSP00000456078   ENSP00000440073  
     ENSP00000455593  
    Reactome Protein details: Q6P4F7
    Human Recombinant Protein Products: 
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    Uscn Proteins for ARHGAP11A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--


    ARHGAP11A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARHGAP11A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGAP11A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q6P4F7

    ProtoNet protein and cluster: Q6P4F7

    1 Blocks protein family: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RHGBA_HUMAN, Q6P4F7
    Similarity: Contains 1 Rho-GAP domain


    Function
    for ARHGAP11A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    hsa-miR-610 hsa-miR-187* hsa-miR-3146 hsa-miR-1283 hsa-miR-135b hsa-miR-19b hsa-miR-466 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP11A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--


    ARHGAP11A for ontologies           About GeneDecksing



    Pathways & Interactions
    for ARHGAP11A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    2Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ARHGAP11A
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP11A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP11A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ARHGAP11A (Q6P4F72, 3 ENSP000003550904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974833 I2D: score=2 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--


    ARHGAP11A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGAP11A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP11A
    Search CenterWatch for drugs/clinical trials and news about ARHGAP11A / RHGBA 

    Transcripts
    for ARHGAP11A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGAP11A gene (2 alternative transcripts): 
    NM_014783.3  NM_199357.1  

    Unigene Cluster for ARHGAP11A:

    Rho GTPase activating protein 11A
    Hs.591130  [show with all ESTs]
    Unigene Representative Sequence: NM_014783
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565905 ENST00000563330 ENST00000361627(uc010ubw.1 uc001zgy.1 uc010ubx.1)
    ENST00000567348(uc001zgw.3) ENST00000563864 ENST00000543522 ENST00000562481
    ENST00000564918

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP11A (see all 12):
    hsa-miR-610 hsa-miR-187* hsa-miR-3146 hsa-miR-1283 hsa-miR-135b hsa-miR-19b hsa-miR-466 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGAP11A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK303025.1 AK316437.1 BC039563.2 BC050545.1 BC063444.1 D87717.2 

    8 DOTS entries:

    DT.113605  DT.97783455  DT.97781987  DT.100021847  DT.100819560  DT.121033548  DT.95375484  DT.95375483 

    24/114 AceView cDNA sequences (see all 114):

    AA262370 BC039563 CB116462 NM_199357 BM479510 BX480697 BQ774758 BQ218492 
    BM988404 BM990266 BQ000398 AW953516 D87717 BU622339 AA355707 BM834084 
    BM791397 AA806195 BC063444 BC050545 AW297913 NM_014783 BE882351 CR625523 

    GeneLoc Exon Structure


    Expression
    for ARHGAP11A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCATTTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARHGAP11A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMeningesBrain
    EyeRetinaEye
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARHGAP11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP11A

    SOURCE GeneReport for Unigene cluster: Hs.591130
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    In Situ
    Assay Products:     
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    Orthologs
    for ARHGAP11A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP11A gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARHGAP11A1 Rho GTPase activating protein 11A 61.23(n)
    51.56(a)    		   423289  NM_001006479.2  NP_001006479.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 35(a)
    		 1 → many
    		 1(32797942-32815043)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC046258.12   -- 74.42(n)    BC046258.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc55g062 wufc55g06 77.47(n)   325115  CA975599.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 16(a)
    		 1 → many
    		 GroupUn.960(669-4348)


    ENSEMBL Gene Tree for ARHGAP11A (if available)
    TreeFam Gene Tree for ARHGAP11A (if available) 

    Paralogs
    for ARHGAP11A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP11A gene
    ARHGAP62  ARHGAP362  STARD132  ARHGAP402  ARHGAP182  DLC12  ARHGAP282  ARHGAP11B2  
    STARD82  
    2 SIMAP similar genes for ARHGAP11A using alignment to 4 protein entries:     RHGBA_HUMAN (see all proteins):
    ARHGAP11B    ARHGAP24

    ARHGAP11A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARHGAP11A
    PGOHUM00000262248


    Genomic Variants
    for ARHGAP11A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in ARHGAP11A are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1908174491,2
    		--32905695(+) TGTGTA/GGGAAA 2 -- us2k10--------
    rs1840456141,2
    		--32905799(+) GATCAC/TGAGGT 2 -- us2k10--------
    rs1384945161,2
    		--32905844(+) AACACC/TGTCTC 2 -- us2k10--------
    rs42933441,2
    		C,A,H,--32906010(+) ACTCCG/ATCACA 2 -- us2k13Minor allele frequency- A:0.17NA 6
    rs118534931,2
    		H--32906013(+) ccatcA/Ccaaaa 2 -- us2k10--------
    rs121482061,2
    		C--32906032(+) AAAAAA/GAGAGA 2 -- us2k1 trp31Minor allele frequency- G:0.00NA 2
    rs1506591911,2
    		--32906168(+) GTGTGC/GAGTTT 2 -- us2k10--------
    rs1886312511,2
    		--32906208(+) AGCAAA/TTTTTT 2 -- us2k10--------
    rs1493658641,2
    		--32906552(+) AGGGCC/GGAAAC 2 -- us2k10--------
    rs1447537731,2
    		--32906592(+) TCTATA/GGCACG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP11A (32907345 - 32932150 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for ARHGAP11A
         12 CNVs: 2191 49525 3075 7058 5324 3956 49523 0185 87615 66768 49519 32019

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ARHGAP11A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGAP11A for disorders           About MalaCards

    ARHGAP11A for disorders           About GeneDecksing

    OMIM gene information: 610589    OMIM disorders: --


    Export disorders for ARHGAP11A gene to outside databases

    Publications
    for ARHGAP11A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP11A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ARHGAP11A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)1, 3 Riley B.... Makoff A. (2002)
    3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    7. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1 Nousiainen M.... Koerner R. (2006)

    External Searches for ARHGAP11A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ARHGAP11A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9824 HGNC: 15783 AceView: ARHGAP11A Ensembl:ENSG00000198826 euGenes: HUgn9824
    ECgene: ARHGAP11A H-InvDB: ARHGAP11A

    Other Databases showing ARHGAP11A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0013

    Specialized Databases showing ARHGAP11A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP11A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARHGAP11A gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGAP11A gene:
    Search GeneIP for patents involving ARHGAP11A

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