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Aliases for ARHGAP11A Gene

Aliases for ARHGAP11A Gene

  • Rho GTPase Activating Protein 11A 2 3
  • KIAA0013 4 6
  • Rho-Type GTPase-Activating Protein 11A 4
  • GAP (1-12) 2

External Ids for ARHGAP11A Gene

Previous GeneCards Identifiers for ARHGAP11A Gene

  • GC15P028150
  • GC15P025615
  • GC15P030486
  • GC15P030623
  • GC15P030694
  • GC15P032907
  • GC15P009778

Summaries for ARHGAP11A Gene

GeneCards Summary for ARHGAP11A Gene

ARHGAP11A (Rho GTPase Activating Protein 11A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11A Gene

Genomics for ARHGAP11A Gene

Regulatory Elements for ARHGAP11A Gene

Genomic Location for ARHGAP11A Gene

Start:
32,615,144 bp from pter
End:
32,639,949 bp from pter
Size:
24,806 bases
Orientation:
Plus strand

Genomic View for ARHGAP11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11A Gene

Proteins for ARHGAP11A Gene

  • Protein details for ARHGAP11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F7-RHGBA_HUMAN
    Recommended name:
    Rho GTPase-activating protein 11A
    Protein Accession:
    Q6P4F7
    Secondary Accessions:
    • B4DZN9
    • Q6PI96
    • Q9Y3S6

    Protein attributes for ARHGAP11A Gene

    Size:
    1023 amino acids
    Molecular mass:
    113866 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP11A Gene

    Alternative splice isoforms for ARHGAP11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP11A Gene

Proteomics data for ARHGAP11A Gene at MOPED

Post-translational modifications for ARHGAP11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP11A Gene

No data available for DME Specific Peptides for ARHGAP11A Gene

Domains for ARHGAP11A Gene

Gene Families for ARHGAP11A Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP11A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4F7

UniProtKB/Swiss-Prot:

RHGBA_HUMAN :
  • Q6P4F7
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP11A: view

Function for ARHGAP11A Gene

Gene Ontology (GO) - Molecular Function for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP11A: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP11A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP11A Gene

Localization for ARHGAP11A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP11A Gene COMPARTMENTS Subcellular localization image for ARHGAP11A gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP11A Gene

Pathways for ARHGAP11A Gene

genes like me logo Genes that share pathways with ARHGAP11A: view

Pathways by source for ARHGAP11A Gene

3 Reactome pathways for ARHGAP11A Gene

Interacting Proteins for ARHGAP11A Gene

Gene Ontology (GO) - Biological Process for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11A: view

Transcripts for ARHGAP11A Gene

Unigene Clusters for ARHGAP11A Gene

Rho GTPase activating protein 11A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP11A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11A Gene

No ASD Table

Relevant External Links for ARHGAP11A Gene

GeneLoc Exon Structure for
ARHGAP11A
ECgene alternative splicing isoforms for
ARHGAP11A

Expression for ARHGAP11A Gene

mRNA expression in normal human tissues for ARHGAP11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP11A Gene

SOURCE GeneReport for Unigene cluster for ARHGAP11A Gene Hs.591130

genes like me logo Genes that share expressions with ARHGAP11A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP11A Gene

Orthologs for ARHGAP11A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP11A 35
  • 99.54 (n)
  • 99.32 (a)
ARHGAP11A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP11A 35
  • 85.27 (n)
  • 77.21 (a)
dog
(Canis familiaris)
Mammalia ARHGAP11A 35
  • 84.99 (n)
  • 76.7 (a)
mouse
(Mus musculus)
Mammalia Arhgap11a 35
  • 78.62 (n)
  • 71.44 (a)
Arhgap11a 16
Arhgap11a 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgap11a 35
  • 79.31 (n)
  • 71.85 (a)
chicken
(Gallus gallus)
Aves ARHGAP11A 35
  • 62.03 (n)
  • 52.66 (a)
ARHGAP11A 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap11a.1 35
  • 55.18 (n)
  • 46.21 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap11a 35
  • 56.51 (n)
  • 51 (a)
arhgap11a 36
  • 41 (a)
OneToMany
wufc55g06 35
fruit fly
(Drosophila melanogaster)
Insecta cv-c 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-1 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 8 (a)
OneToMany
Species with no ortholog for ARHGAP11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11A Gene

ENSEMBL:
Gene Tree for ARHGAP11A (if available)
TreeFam:
Gene Tree for ARHGAP11A (if available)

Paralogs for ARHGAP11A Gene

Selected SIMAP similar genes for ARHGAP11A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP11A Gene

genes like me logo Genes that share paralogs with ARHGAP11A: view

Variants for ARHGAP11A Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4479199 -- 32,618,430(+) TTTTT(A/T)AAATA intron-variant
rs4480773 -- 32,619,120(+) GAGTG(A/G)TTTTT intron-variant
rs4594234 -- 32,619,307(+) AATTT(A/G)CCTTT intron-variant
rs4595774 -- 32,619,169(+) TAAAT(A/G)CTTCT intron-variant
rs4779582 -- 32,638,304(+) CTGAC(C/G)TTGTG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11A Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
nsv517740 CNV Gain+Loss 19592680
dgv728e1 CNV Complex 17122850
dgv2318n71 CNV Loss 21882294
nsv903959 CNV Gain 21882294
dgv729e1 CNV Complex 17122850
esv2422296 CNV Duplication 17116639
nsv469587 CNV Loss 16826518
nsv483039 CNV Gain 15286789
esv21965 CNV Gain+Loss 19812545
nsv9239 CNV Loss 18304495
nsv456785 CNV Gain 19166990
nsv1481 CNV Loss 18451855

Relevant External Links for ARHGAP11A Gene

HapMap Linkage Disequilibrium report
ARHGAP11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11A Gene

Disorders for ARHGAP11A Gene

No disorders were found for ARHGAP11A Gene.

No data available for UniProtKB/Swiss-Prot for ARHGAP11A Gene

Publications for ARHGAP11A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 3

Products for ARHGAP11A Gene

Sources for ARHGAP11A Gene

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