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Aliases for ARHGAP11A Gene

Aliases for ARHGAP11A Gene

  • Rho GTPase Activating Protein 11A 2 3
  • Rho-Type GTPase-Activating Protein 11A 4
  • GAP (1-12) 2
  • KIAA0013 4

External Ids for ARHGAP11A Gene

Previous GeneCards Identifiers for ARHGAP11A Gene

  • GC15P028150
  • GC15P025615
  • GC15P030486
  • GC15P030623
  • GC15P030694
  • GC15P032907
  • GC15P009778

Summaries for ARHGAP11A Gene

GeneCards Summary for ARHGAP11A Gene

ARHGAP11A (Rho GTPase Activating Protein 11A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11A Gene

Genomics for ARHGAP11A Gene

Regulatory Elements for ARHGAP11A Gene

Genomic Location for ARHGAP11A Gene

Chromosome:
15
Start:
32,613,733 bp from pter
End:
32,639,949 bp from pter
Size:
26,217 bases
Orientation:
Plus strand

Genomic View for ARHGAP11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11A Gene

Proteins for ARHGAP11A Gene

  • Protein details for ARHGAP11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F7-RHGBA_HUMAN
    Recommended name:
    Rho GTPase-activating protein 11A
    Protein Accession:
    Q6P4F7
    Secondary Accessions:
    • B4DZN9
    • Q6PI96
    • Q9Y3S6

    Protein attributes for ARHGAP11A Gene

    Size:
    1023 amino acids
    Molecular mass:
    113866 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP11A Gene

    Alternative splice isoforms for ARHGAP11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP11A Gene

Proteomics data for ARHGAP11A Gene at MOPED

Post-translational modifications for ARHGAP11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ARHGAP11A Gene

Domains & Families for ARHGAP11A Gene

Gene Families for ARHGAP11A Gene

Protein Domains for ARHGAP11A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4F7

UniProtKB/Swiss-Prot:

RHGBA_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP11A: view

Function for ARHGAP11A Gene

Gene Ontology (GO) - Molecular Function for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP11A: view

Phenotypes for ARHGAP11A Gene

GenomeRNAi human phenotypes for ARHGAP11A:
genes like me logo Genes that share phenotypes with ARHGAP11A: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP11A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP11A Gene

Localization for ARHGAP11A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP11A Gene COMPARTMENTS Subcellular localization image for ARHGAP11A gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP11A Gene

Pathways & Interactions for ARHGAP11A Gene

genes like me logo Genes that share pathways with ARHGAP11A: view

Pathways by source for ARHGAP11A Gene

3 Reactome pathways for ARHGAP11A Gene

Interacting Proteins for ARHGAP11A Gene

Gene Ontology (GO) - Biological Process for ARHGAP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11A: view

No data available for SIGNOR curated interactions for ARHGAP11A Gene

Drugs & Compounds for ARHGAP11A Gene

No Compound Related Data Available

Transcripts for ARHGAP11A Gene

Unigene Clusters for ARHGAP11A Gene

Rho GTPase activating protein 11A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP11A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11A Gene

No ASD Table

Relevant External Links for ARHGAP11A Gene

GeneLoc Exon Structure for
ARHGAP11A
ECgene alternative splicing isoforms for
ARHGAP11A

Expression for ARHGAP11A Gene

mRNA expression in normal human tissues for ARHGAP11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP11A Gene

This gene is overexpressed in Cerebrospinal fluid (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP11A Gene



SOURCE GeneReport for Unigene cluster for ARHGAP11A Gene Hs.591130

genes like me logo Genes that share expression patterns with ARHGAP11A: view

Protein tissue co-expression partners for ARHGAP11A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGAP11A Gene

Orthologs for ARHGAP11A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP11A 35
  • 85.27 (n)
  • 77.21 (a)
dog
(Canis familiaris)
Mammalia ARHGAP11A 35
  • 84.99 (n)
  • 76.7 (a)
mouse
(Mus musculus)
Mammalia Arhgap11a 35
  • 78.62 (n)
  • 71.44 (a)
Arhgap11a 16
Arhgap11a 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP11A 35
  • 99.54 (n)
  • 99.32 (a)
ARHGAP11A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap11a 35
  • 79.31 (n)
  • 71.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGAP11A 35
  • 62.03 (n)
  • 52.66 (a)
ARHGAP11A 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap11a.1 35
  • 55.18 (n)
  • 46.21 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap11a 35
  • 56.51 (n)
  • 51 (a)
wufc55g06 35
arhgap11a 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cv-c 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-1 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
  • 8 (a)
OneToMany
Species with no ortholog for ARHGAP11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11A Gene

ENSEMBL:
Gene Tree for ARHGAP11A (if available)
TreeFam:
Gene Tree for ARHGAP11A (if available)

Paralogs for ARHGAP11A Gene

(2) SIMAP similar genes for ARHGAP11A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARHGAP11A Gene

genes like me logo Genes that share paralogs with ARHGAP11A: view

Variants for ARHGAP11A Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs375099725 -- 32,635,946(+) TTTTA(A/C/T)CTAAA intron-variant, utr-variant-3-prime
rs375068104 -- 32,635,870(+) AAACA(A/G)GTTTG missense, reference
rs375059268 -- 32,637,750(+) GGAGA(A/C/T)CATCA missense, reference
rs374926086 -- 32,636,326(+) TTACC(A/G)GATGT missense, reference, downstream-variant-500B
rs374907001 -- 32,617,451(+) TTTTC(A/C)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11A Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
nsv517740 CNV Gain+Loss 19592680
dgv728e1 CNV Complex 17122850
dgv2318n71 CNV Loss 21882294
nsv903959 CNV Gain 21882294
dgv729e1 CNV Complex 17122850
esv2422296 CNV Duplication 17116639
nsv469587 CNV Loss 16826518
nsv483039 CNV Gain 15286789
esv21965 CNV Gain+Loss 19812545
nsv9239 CNV Loss 18304495
nsv456785 CNV Gain 19166990
nsv1481 CNV Loss 18451855

Variation tolerance for ARHGAP11A Gene

Residual Variation Intolerance Score: 24.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP11A Gene

HapMap Linkage Disequilibrium report
ARHGAP11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11A Gene

Disorders for ARHGAP11A Gene

Relevant External Links for ARHGAP11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP11A
genes like me logo Genes that share disorders with ARHGAP11A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP11A Gene

Publications for ARHGAP11A Gene

  1. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B. … Makoff A. (Genomics 2002) 2 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67

Products for ARHGAP11A Gene

Sources for ARHGAP11A Gene

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