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ARHGAP10 Gene

protein-coding   GIFtS: 57
GCID: GC04P148653

Rho GTPase Activating Protein 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 101 2     GTPase Regulator Associated With Focal Adhesion Kinase 22 3
GRAF22 3 5     PSGAP2 5
Graf-Related Protein 22 3     PS-GAP2
Rho-Type GTPase-Activating Protein 102 3     Rho GTPase-Activating Protein 102

External Ids:    HGNC: 260991   Entrez Gene: 796582   Ensembl: ENSG000000712057   OMIM: 6097465   UniProtKB: A1A4S63   

Export aliases for ARHGAP10 gene to outside databases

Previous GC identifers: GC10M024607 GC10M025022 GC04P149232 GC04P149011 GC04P148872 GC04P144380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARHGAP10 Gene:
ARHGAP10 (Rho GTPase activating protein 10) is a protein-coding gene. GO annotations related to this gene include Rho GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.
Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic
fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region.
Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP10 gene promoter:
         Max1   AML1a   Pax-5   Pbx1a   POU2F1a   HNF-4alpha2   Pax-4a   HNF-4alpha1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP10 promoter sequence
   Search Chromatin IP Primers for ARHGAP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.23   Ensembl cytogenetic band:  4q31.23   HGNC cytogenetic band: 4q31.23

ARHGAP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P148653:  view genomic region     (about GC identifiers)

Start:
148,653,214 bp from pter      End:
148,993,931 bp from pter
Size:
340,718 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 10  
Size: 786 amino acids; 89375 Da
Subunit: Interacts with PKN3. Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction
does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42. Interacts via its SH3 domain with
PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity
(By similarity)
Sequence caution: Sequence=AAI26900.1; Type=Frameshift; Positions=785;
1 PDB 3D structure from and Proteopedia for ARHGAP10:
2MIO (3D)    
Secondary accessions: A1L0S5 Q2VPC4 Q2VPC5 Q96EV3 Q96S75

Explore the universe of human proteins at neXtProt for ARHGAP10: NX_A1A4S6

Explore proteomics data for ARHGAP10 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylated in vitro by constitutive active PKN31
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGAP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078881.3  
    ENSEMBL proteins: 
     ENSP00000336923   ENSP00000422358   ENSP00000406624  
    Reactome Protein details: A1A4S6

    ARHGAP10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry A1A4S6

    ProtoNet protein and cluster: A1A4S6

    UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ARHGAP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG10_HUMAN, A1A4S6
    Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.
    Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic
    fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region.
    Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity IEA--
    GO:0005515protein binding IPI11432776
         
    Find genes that share ontologies with ARHGAP10           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARHGAP10

    miRNA
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    miRTarBase miRNAs that target ARHGAP10:
    hsa-mir-17-5p (MIRT051013)

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    hsa-miR-579 hsa-miR-214 hsa-miR-204 hsa-miR-205* hsa-miR-761 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG10_HUMAN, A1A4S6: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane (By
    similarity). Note=Association to cell membrane is dependent on PH domain (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with ARHGAP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP10 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Regulation of PAK-2p34 activity by PS-GAP/RHG100.00
    Apoptosis0.38
    2Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    3Signaling by GPCR
    Signal Transduction0.58
    4Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells


    Find genes that share SuperPaths with ARHGAP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ARHGAP10
        Regulation of PAK-2p34 activity by PS-GAP/RHG10
    Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for ARHGAP10):
        Bacterial invasion of epithelial cells

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP10
    Interactions:

        GeneGlobe Interaction Network for ARHGAP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ARHGAP10 (A1A4S61, 3 ENSP000003369234) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKN3Q6P5Z21, 3, ENSP000002919064EBI-1390944,EBI-1384335 I2D: score=3 STRING: ENSP00000291906
    PAK2Q131773, ENSP000003140674I2D: score=1 STRING: ENSP00000314067
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    PKN1Q165123, ENSP000003433254I2D: score=1 STRING: ENSP00000343325
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007010cytoskeleton organization IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032321positive regulation of Rho GTPase activity ----

    Find genes that share ontologies with ARHGAP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ARHGAP10 (RHG10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP10 gene: 
    NM_024605.3  

    Unigene Cluster for ARHGAP10:

    Rho GTPase activating protein 10
    Hs.368631  [show with all ESTs]
    Unigene Representative Sequence: NM_024605
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510379(uc003ile.1) ENST00000336498(uc003ilf.3 uc003ilg.3)
    ENST00000506054 ENST00000507661 ENST00000506020(uc003ilh.3 uc003ili.3)
    ENST00000513548 ENST00000510076 ENST00000414545
    miRNA
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    hsa-miR-579 hsa-miR-214 hsa-miR-204 hsa-miR-205* hsa-miR-761 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP10 3' UTR sequence
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    Additional mRNA sequence: 

    AB050785.1 AK024549.1 AK096041.1 AK123034.1 AK304458.1 AL834360.1 BC011920.2 BC047914.1 
    BC106018.1 BC109029.2 BC109030.1 BC126899.1 BC128055.1 CR457328.1 

    8 DOTS entries:

    DT.112671  DT.100025867  DT.95367758  DT.99965208  DT.91674823  DT.99971384  DT.95367757  DT.101963030 

    Selected AceView cDNA sequences (see all 61):

    CB126525 BF773310 CF272304 AI245305 AI357709 AW139688 AA307147 BP381705 
    AI167698 AA486536 CA449757 BM717959 AI571949 CD245739 BQ013751 BU682155 
    BU679645 BE276311 BG251431 BU742168 AK024549 BI862326 BE302841 BP381997 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:                                                                    -                             -                                       
    SP2:                                                                    -                             -                                       
    SP3:                                                                    -                             -                 -     -               
    SP4:                                                                                                  -                                       
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ARHGAP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGATTTT
    ARHGAP10 Expression
    About this image


    ARHGAP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    ARHGAP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368631

    UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
    Tissue specificity: High levels of expression in heart and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap101 , 5 Rho GTPase activating protein 101, 5 86.9(n)1
    91.48(a)1
      8 (36.60 cM)5
    785141  NM_030113.21  NP_084389.21 
     772503665 
    chicken
    (Gallus gallus)
    Aves ARHGAP101 Rho GTPase activating protein 10 77.55(n)
    81.23(a)
      422471  XM_420436.3  XP_420436.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP106
    Rho GTPase activating protein 10
    79(a)
    1 ↔ 1
    5(133922213-134069772)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183592 Xenopus laevis transcribed sequence with weak similarity more 77.38(n)    BJ621340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap101 Rho GTPase activating protein 10 63.44(n)
    64.06(a)
      692277  NM_001045250.1  NP_001038715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP19D3   -- 44(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C04D8.13 GTPase-activating protein 47(a)   III(8569502-8590130)   --


    ENSEMBL Gene Tree for ARHGAP10 (if available)
    TreeFam Gene Tree for ARHGAP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP10 gene
    ARHGAP212  ARHGAP272  CHN22  ARHGAP232  ARHGAP92  CHN12  ARHGAP262  ARHGAP152  
    ARHGAP122  OPHN12  ARHGAP422  
    17 SIMAP similar genes for ARHGAP10 using alignment to 5 protein entries:     RHG10_HUMAN (see all proteins):
    GRAF    DKFZp667D142    FLJ20896    OPHN1    ARHGAP12    CHN2
    CHN1    SH3GL2    ARHGAP26    ARHGAP21    ARHGAP31    ARHGAP24
    ARHGEF7    ARHGAP42    ARHGAP23    ITSN1    ARHGAP9

    Find genes that share paralogs with ARHGAP10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGAP10 (see all 6817)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009358171,2
    Cuntested1148827800(+) CGTTTC/G/TCTTGA 2 S F mis11EU 1323
    rs1838470281,2
    --148651630(+) TAGTAA/GGAACT 1 -- us2k10--------
    rs1493637361,2
    C--148651744(+) TGTTTC/TGTAAC 1 -- us2k10--------
    rs729514291,2
    C,F--148651763(+) TTATTG/TAGTAG 1 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1446752161,2
    C--148651896(+) TTACCA/TTCATA 1 -- us2k10--------
    rs1876497681,2
    --148651920(+) TATCGC/TGAGTT 1 -- us2k10--------
    rs1394222891,2
    --148651958(+) GCCCGA/GCACAT 1 -- us2k10--------
    rs1483296101,2
    C--148652018(+) TAGTG-/TTTTTT 1 -- us2k10--------
    rs106667041,2
    C--148652036(+) TTTTT-/TT/TTT
            
    GAGAC
    2 -- us2k1 cds11NA 2
    rs1919975701,2
    --148652149(+) TGCCTC/TAGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP10 (148653214 - 148903214 bp, first 250kb of ARHGAP10)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ARHGAP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv292987CNV Insertion16902084
    dgv5780n71CNV Loss21882294
    nsv880242CNV Gain21882294
    esv274865CNV Gain+Loss21479260
    esv259874OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP10
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609746    OMIM disorders: --


    Find genes that share disorders with ARHGAP10           About GenesLikeMe

    Genetic Association Database (GAD): ARHGAP10
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP10 (4 documents)

    Export disorders for ARHGAP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP10 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGAP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    3. A genome-wide association study of prognosis in breast cancer. (PubMed id 20332263)1, 4 Azzato E.M....Kraft P. (amp 2010)
    4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1, 4 Marroni F....Pramstaller P.P. (Circ Cardiovasc Genet 2009)
    5. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. (PubMed id 11432776)1, 2 Shibata H.... Ono Y. (J. Biochem. 2001)
    6. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PubMed id 8288572)1, 3 Lancaster C.A....Hall A. (J. Biol. Chem. 1994)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. (PubMed id 20158304)1 Lind P.A....Madden P.A. (Twin Res Hum Genet 2010)
    10. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79658 HGNC: 26099 AceView: ARHGAP10.1 Ensembl:ENSG00000071205 euGenes: HUgn79658
    ECgene: ARHGAP10 Kegg: 79658 H-InvDB: ARHGAP10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGAP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP10 gene:
    Search GeneIP for patents involving ARHGAP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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