ARHGAP10 Gene
protein-coding GIFtS : 53
GCID: GC04 P148653
Rho GTPase activating protein 10
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor ARHGAP10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Rho GTPase Activating Protein 10 1 2 PSGAP2 5 GRAF21 2 3 5 FLJ208961 Graf-Related Protein 22 3 FLJ417911 Rho-Type GTPase-Activating Protein 102 3 PS-GAP2 GTPase Regulator Associated With Focal Adhesion Kinase 22 3 Rho GTPase-Activating Protein 102
Export aliases for ARHGAP10 gene to outside databases Previous GC identifers: GC10M024607 GC10M025022 GC04P149232 GC04P149011 GC04P148872 GC04P144380
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor ARHGAP10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 Function : GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor ARHGAP10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARHGAP10 gene promoter: Max1 AML1a Pax-5 Pbx1a POU2F1a HNF-4alpha2 Pax-4a HNF-4alpha1 Arnt Other transcription factors Search SABiosciences Chromatin IP Primers for ARHGAP10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARHGAP10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q31.23 Ensembl cytogenetic band: 4q31.23 HGNC chromosome: 4 ARHGAP10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P148653: view genomic region
(about GC identifiers )
Start:
148,653,214 bp from pter
End:
148,993,931 bp from pter
Size:
340,718 bases
Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor ARHGAP10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 (See
protein sequence )Recommended Name: Rho GTPase-activating protein 10 Size : 786 amino acids; 89375 Da
Subunit : Interacts with PKN3. Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction doesnot affect ARHGAP10 GTPase activation activity towards RHOA and CDC42. Interacts via its SH3 domain with PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity (By similarity)
Subcellular location : Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane (Bysimilarity). Note=Association to cell membrane is dependent on PH domain (By similarity)
Sequence caution : Sequence=AAI26900.1; Type=Frameshift; Positions=785;
Secondary accessions : A1L0S5 Q2VPC4 Q2VPC5 Q96EV3 Q96S75Explore the universe of human proteins at neXtProt for ARHGAP10: NX_A1A4S6 Post-translational modifications:
Phosphorylated. Phosphorylated in vitro by constitutive active PKN31
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A1A4S6 ARHGAP10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078881.3 ENSEMBL proteins: ENSP00000336923 ENSP00000422358 ENSP00000406624 Reactome Protein details: A1A4S6 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ARHGAP10 for ontologies About GeneDecksing ARHGAP10 Antibody Products: Assay Products for ARHGAP10:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor ARHGAP10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ARHGAP10 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry A1A4S6 ProtoNet protein and cluster: A1A4S6
UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 Similarity : Contains 1 BAR domainSimilarity : Contains 1 PH domainSimilarity : Contains 1 Rho-GAP domainSimilarity : Contains 1 SH3 domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor ARHGAP10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 Function : GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARHGAP10 (NM_024605 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARHGAP10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP10
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
ARHGAP10 for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor ARHGAP10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Cell death signalling via NRAGE, NRIF and NADE 3 Regulation of PAK-2p34 activity by PS-GAP/RHG10 4 Bacterial invasion of epithelial cells 5 Signaling by GPCR
Pathway sources See GeneCards unified pathways Show all pathways 5/6
Reactome Pathways for ARHGAP10 (see all 6 )1
Kegg Pathway (Kegg details for ARHGAP10) :
ARHGAP10 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP10 STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/10 Interacting proteins for ARHGAP10 (A1A4S6 1 , 3 ENSP00000336923 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 10 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006915 apoptotic process
TAS -- GO:0007010 cytoskeleton organization
IEA -- GO:0007165 signal transduction
-- -- GO:0007264 small GTPase mediated signal transduction
TAS -- GO:0032321 positive regulation of Rho GTPase activity
-- --
ARHGAP10 for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor ARHGAP10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARHGAP10 Search CenterWatch for drugs/clinical trials and news about ARHGAP10 / RHG10
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor ARHGAP10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARHGAP10 gene: NM_024605.3 Unigene Cluster for ARHGAP10:
Rho GTPase activating protein 10 Hs.368631 [show with all ESTs ] Unigene Representative Sequence: NM_024605 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000510379 (uc003ile.1 ) ENST00000336498 (uc003ilf.3 uc003ilg.3 )ENST00000506054 ENST00000507661 ENST00000506020 (uc003ilh.3 uc003ili.3 )ENST00000513548 ENST00000510076 ENST00000414545 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARHGAP10 (NM_024605 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGAP10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARHGAP10
Additional cDNA sequence: AB050785.1 AK024549.1 AK096041.1 AK123034.1 AK304458.1 AL834360.1 BC011920.2 BC047914.1 BC106018.1 BC109029.2 BC109030.1 BC126899.1 BC128055.1 CR457328.1
8 DOTS entries : DT.112671 DT.100025867
DT.95367758 DT.99965208 DT.91674823 DT.99971384 DT.95367757 DT.101963030 24/61 AceView cDNA sequences (see all 61 ):
BP381705 AI167698 AA486536 CA449757 AI571949 BM717959 CF272304 CD245739 AI245305 AI357709 AW139688 AA307147 BQ013751 BF773310 CB126525 BF312711 BI093467 CD517044 BU633780 AA872017 AA872016 AI085546 CA431898 CA442818 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP10 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 SP1 :                       -           -               SP2 :                       -           -               SP3 :                       -           -       -   -       SP4 :                                 -               SP5 :                                              
ECgene alternative splicing isoforms for ARHGAP10
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for ARHGAP10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARHGAP10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAAGATTTT
About this image ARHGAP10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category N2/LSB/S/F8/CHIR-induced cells (Generation of midbra... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ARHGAP10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARHGAP10 SOURCE GeneReport for Unigene cluster: Hs.368631 UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 Tissue specificity : High levels of expression in heart and skeletal muscle SABiosciences Custom PCR Arrays for ARHGAP10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARHGAP10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ARHGAP10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARHGAP10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARHGAP10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP10
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor ARHGAP10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ARHGAP10 gene from 6/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ARHGAP101
Rho GTPase activating protein 10
77.19(n) 81.13(a)
 
422471 XM_001232914.2 XP_001232915.1
lizard (Anolis carolinensis)
Reptilia
ARHGAP106
--
79(a)
1 ↔ 1
5(133922348-134068802)
African clawed frog (Xenopus laevis)
Amphibia
Xl.183592
Xenopus laevis transcribed sequence with weak similarity more
77.38(n)
 
BJ621340.1
zebrafish (Danio rerio)
Actinopterygii
arhgap101
Rho GTPase activating protein 10
64.23(n) 64.36(a)
 
692277 NM_001045250.1 NP_001038715.1
fruit fly (Drosophila melanogaster)
Insecta
RhoGAP19D3
--
44(a)
 
--
worm (Caenorhabditis elegans)
Secernentea
C04D8.13
GTPase-activating protein
47(a)
 
III(8569502-8590130) --
ENSEMBL Gene Tree for ARHGAP10 (if available)TreeFam Gene Tree for ARHGAP10 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor ARHGAP10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARHGAP10 gene HMHA1 2 ARHGAP21 2 ARHGAP27 2 CHN2 2 ARHGAP23 2 ARHGAP9 2 ARHGAP29 2 ARHGAP26 2 CHN1 2 ARHGAP15 2 ARHGAP12 2 OPHN1 2 GMIP 2 ARHGAP42 2 17 SIMAP similar genes for ARHGAP10 using alignment to 5 protein entries: RHG10_HUMAN (see all proteins ):GRAF DKFZp667D142 FLJ20896 OPHN1 ARHGAP12 CHN2 CHN1 SH3GL2 ARHGAP26 ARHGAP21 ARHGAP31 ARHGAP24 ARHGEF7 ARHGAP42 ARHGAP23 ITSN1 ARHGAP9
ARHGAP10 for paralogs About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor ARHGAP10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARHGAP10
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor ARHGAP10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ARHGAP10 for disorders About GeneDecksing
OMIM gene information: 609746
OMIM disorders : --2 diseases for ARHGAP10 : About MalaCards hypertrichosis spasticity Human Genome Epidemiology (HuGE) Navigator: ARHGAP10 (4 documents) Export disorders for ARHGAP10 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor ARHGAP10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARHGAP10 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with ARHGAP10) Utopia : connect your pdf to the dynamic world of online information
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. (PubMed id 11432776) 1 , 2 Shibata H.... Ono Y. (2001) Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PubMed id 8288572) 1 , 3 Lancaster C.A....Hall A. (1994) Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502) 1 Kennedy R.B....Poland G.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011) 1 Takefuji M....Kaibuchi K. (2010) A genome-wide association study of prognosis in breas t cancer. (PubMed id 20332263) 1 Azzato E.M....Kraft P. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A genomewide association study of nicotine and alcoho l dependence in Australian and Dutch populations. (PubMed id 20158304) 1 Lind P.A....Madden P.A. (2010) A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603) 1 Marroni F....Pramstaller P.P. (2009) Comprehensive proteomic analysis of interphase and mi totic 14-3-3-binding proteins. (PubMed id 15161933) 1 Meek S.E....Piwnica-Worms H. (2004)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for ARHGAP10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing ARHGAP10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing ARHGAP10 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing ARHGAP10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ARHGAP10 Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for ARHGAP10 gene: Search GeneIP for patents involving ARHGAP10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor ARHGAP10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ARHGAP10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ARHGAP10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARHGAP10 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARHGAP10 OriGene 3'-UTR Clone for ARHGAP10 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARHGAP10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARHGAP10 OriGene Custom Protein Services for ARHGAP10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARHGAP10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARHGAP10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ARHGAP10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARHGAP10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARHGAP10
ARHGAP10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP10
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARHGAP10
Jump to Section...
Aliases for ARHGAP10
Databases for ARHGAP10
Disorders / Diseases for ARHGAP10
Domains / Families for ARHGAP10
Drugs / Compounds for ARHGAP10
Expression for ARHGAP10
Function for ARHGAP10
Genomic Views for ARHGAP10
Intellectual Property for ARHGAP10
Orthologs for ARHGAP10
Paralogs for ARHGAP10
Pathways / Interactions for ARHGAP10
Products for ARHGAP10
Proteins for ARHGAP10
Publications for ARHGAP10
Search Box for ARHGAP10
Summaries for ARHGAP10
Transcripts for ARHGAP10
Variants for ARHGAP10
TOP
BOTTOM