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Aliases for ARHGAP10 Gene

Aliases for ARHGAP10 Gene

  • Rho GTPase Activating Protein 10 2 3
  • GRAF2 3 4 6
  • GTPase Regulator Associated With Focal Adhesion Kinase 2 3 4
  • Rho-Type GTPase-Activating Protein 10 3 4
  • Graf-Related Protein 2 3 4
  • PSGAP 3 6
  • Rho GTPase-Activating Protein 10 3
  • PS-GAP 3

External Ids for ARHGAP10 Gene

Previous GeneCards Identifiers for ARHGAP10 Gene

  • GC10M024607
  • GC10M025022
  • GC04P149232
  • GC04P149011
  • GC04P148872
  • GC04P148653
  • GC04P144380

Summaries for ARHGAP10 Gene

GeneCards Summary for ARHGAP10 Gene

ARHGAP10 (Rho GTPase Activating Protein 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for ARHGAP10 Gene

  • GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP10 Gene

Genomics for ARHGAP10 Gene

Regulatory Elements for ARHGAP10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP10 Gene

Start:
147,732,063 bp from pter
End:
148,072,780 bp from pter
Size:
340,718 bases
Orientation:
Plus strand

Genomic View for ARHGAP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP10 Gene

Proteins for ARHGAP10 Gene

  • Protein details for ARHGAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4S6-RHG10_HUMAN
    Recommended name:
    Rho GTPase-activating protein 10
    Protein Accession:
    A1A4S6
    Secondary Accessions:
    • A1L0S5
    • Q2VPC4
    • Q2VPC5
    • Q96EV3
    • Q96S75

    Protein attributes for ARHGAP10 Gene

    Size:
    786 amino acids
    Molecular mass:
    89375 Da
    Quaternary structure:
    • Interacts with PKN3. Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42. Interacts via its SH3 domain with PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity (By similarity).
    SequenceCaution:
    • Sequence=AAI26900.1; Type=Frameshift; Positions=785; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP10 Gene

neXtProt entry for ARHGAP10 Gene

Proteomics data for ARHGAP10 Gene at MOPED

Post-translational modifications for ARHGAP10 Gene

  • Phosphorylated. Phosphorylated in vitro by constitutive active PKN3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP10 Gene

Domains for ARHGAP10 Gene

Gene Families for ARHGAP10 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for ARHGAP10 Gene

Suggested Antigen Peptide Sequences for ARHGAP10 Gene

Graphical View of Domain Structure for InterPro Entry

A1A4S6

UniProtKB/Swiss-Prot:

RHG10_HUMAN :
  • A1A4S6
Domain:
  • Contains 1 BAR domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP10: view

Function for ARHGAP10 Gene

Molecular function for ARHGAP10 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 11432776
genes like me logo Genes that share ontologies with ARHGAP10: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP10 Gene

miRTarBase miRNAs that target ARHGAP10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGAP10 Gene

Localization for ARHGAP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP10 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP10 Gene COMPARTMENTS Subcellular localization image for ARHGAP10 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGAP10: view

Pathways for ARHGAP10 Gene

genes like me logo Genes that share pathways with ARHGAP10: view

Pathways by source for ARHGAP10 Gene

Gene Ontology (GO) - Biological Process for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0007010 cytoskeleton organization IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0012501 programmed cell death TAS --
genes like me logo Genes that share ontologies with ARHGAP10: view

Transcripts for ARHGAP10 Gene

Unigene Clusters for ARHGAP10 Gene

Rho GTPase activating protein 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for ARHGAP10 Gene

GeneLoc Exon Structure for
ARHGAP10
ECgene alternative splicing isoforms for
ARHGAP10

Expression for ARHGAP10 Gene

mRNA expression in normal human tissues for ARHGAP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP10 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.5) and Esophagus - Muscularis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP10 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP10 Gene Hs.368631

mRNA Expression by UniProt/SwissProt for ARHGAP10 Gene

A1A4S6-RHG10_HUMAN
Tissue specificity: High levels of expression in heart and skeletal muscle.
genes like me logo Genes that share expressions with ARHGAP10: view

In Situ Assay Products

Orthologs for ARHGAP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP10 35
  • 98.85 (n)
  • 98.72 (a)
ARHGAP10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP10 35
  • 89.81 (n)
  • 93.25 (a)
ARHGAP10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP10 35
  • 91.43 (n)
  • 93.77 (a)
ARHGAP10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap10 35
  • 86.9 (n)
  • 91.48 (a)
Arhgap10 16
Arhgap10 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGAP10 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP10 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap10 35
  • 86.6 (n)
  • 90.97 (a)
chicken
(Gallus gallus)
Aves ARHGAP10 35
  • 77.55 (n)
  • 81.23 (a)
ARHGAP10 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGAP10 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18359 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap10 35
  • 71.74 (n)
  • 73.84 (a)
Str.18454 35
zebrafish
(Danio rerio)
Actinopterygii arhgap10 35
  • 63.44 (n)
  • 64.06 (a)
arhgap10 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Graf 36
  • 31 (a)
OneToMany
RhoGAP19D 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea T04C9.1 36
  • 33 (a)
OneToMany
C04D8.1 37
  • 47 (a)
Species with no ortholog for ARHGAP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP10 Gene

ENSEMBL:
Gene Tree for ARHGAP10 (if available)
TreeFam:
Gene Tree for ARHGAP10 (if available)

Paralogs for ARHGAP10 Gene

genes like me logo Genes that share paralogs with ARHGAP10: view

Variants for ARHGAP10 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9724 -- 148,072,706(+) TCACC(C/G)GTGTG utr-variant-3-prime
rs168367 -- 147,935,156(-) CAGAC(A/G)GCTCG intron-variant
rs168368 -- 147,945,091(-) CACGC(C/T)TCTAA intron-variant
rs180952 -- 147,932,728(-) acaga(C/T)catcc intron-variant
rs182989 -- 147,930,597(-) AATTG(C/T)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP10 Gene

Variant ID Type Subtype PubMed ID
nsv880242 CNV Gain 21882294
dgv5780n71 CNV Loss 21882294
esv274865 CNV Gain+Loss 21479260
nsv292987 CNV Insertion 16902084
esv259874 OTHER Complex 20981092

Relevant External Links for ARHGAP10 Gene

HapMap Linkage Disequilibrium report
ARHGAP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP10 Gene

Disorders for ARHGAP10 Gene

Relevant External Links for ARHGAP10

Genetic Association Database (GAD)
ARHGAP10
Human Genome Epidemiology (HuGE) Navigator
ARHGAP10
genes like me logo Genes that share disorders with ARHGAP10: view

No data available for UniProtKB/Swiss-Prot for ARHGAP10 Gene

Publications for ARHGAP10 Gene

  1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PMID: 8288572) Lancaster C.A. … Hall A. (J. Biol. Chem. 1994) 2 3
  2. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. (PMID: 11432776) Shibata H. … Ono Y. (J. Biochem. 2001) 3 4
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F. … Pramstaller P.P. (Circ Cardiovasc Genet 2009) 3 48
  5. A genome-wide association study of prognosis in breast cancer. (PMID: 20332263) Azzato E.M. … Kraft P. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 48

Products for ARHGAP10 Gene

Sources for ARHGAP10 Gene

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