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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP10 Gene

protein-coding   GIFtS: 56
GCID: GC04P148653

Rho GTPase Activating Protein 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 101 2     GTPase Regulator Associated With Focal Adhesion Kinase 22 3
GRAF22 3 5     PSGAP2 5
Graf-Related Protein 22 3     PS-GAP2
Rho-Type GTPase-Activating Protein 102 3     Rho GTPase-Activating Protein 102

External Ids:    HGNC: 260991   Entrez Gene: 796582   Ensembl: ENSG000000712057   OMIM: 6097465   UniProtKB: A1A4S63   

Export aliases for ARHGAP10 gene to outside databases

Previous GC identifers: GC10M024607 GC10M025022 GC04P149232 GC04P149011 GC04P148872 GC04P144380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARHGAP10 Gene: 
ARHGAP10 (Rho GTPase activating protein 10) is a protein-coding gene. Diseases associated with ARHGAP10 include hypertrichosis, and smallpox, and among its related super-pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by Rho GTPases. GO annotations related to this gene include Rho GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.
Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic
fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region.
Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP10 gene promoter:
         Max1   AML1a   Pax-5   Pbx1a   POU2F1a   HNF-4alpha2   Pax-4a   HNF-4alpha1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.23   Ensembl cytogenetic band:  4q31.23   HGNC cytogenetic band: 4q31.23

ARHGAP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P148653:  view genomic region     (about GC identifiers)

Start:
148,653,214 bp from pter      End:
148,993,931 bp from pter
Size:
340,718 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 10  
Size: 786 amino acids; 89375 Da
Subunit: Interacts with PKN3. Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction
does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42. Interacts via its SH3 domain with
PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity
(By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane (By
similarity). Note=Association to cell membrane is dependent on PH domain (By similarity)
Sequence caution: Sequence=AAI26900.1; Type=Frameshift; Positions=785;
Secondary accessions: A1L0S5 Q2VPC4 Q2VPC5 Q96EV3 Q96S75

Explore the universe of human proteins at neXtProt for ARHGAP10: NX_A1A4S6

Explore proteomics data for ARHGAP10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylated in vitro by constitutive active PKN3
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1A4S6

  • ARHGAP10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP10 Protein Expression
    REFSEQ proteins: NP_078881.3  
    ENSEMBL proteins: 
     ENSP00000336923   ENSP00000422358   ENSP00000406624  
    Reactome Protein details: A1A4S6
    Human Recombinant Protein Products for ARHGAP10: 
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    Cloud-Clone Corp. Proteins for ARHGAP10 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    ARHGAP10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    5 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry A1A4S6

    ProtoNet protein and cluster: A1A4S6

    UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    ARHGAP10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG10_HUMAN, A1A4S6
    Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state.
    Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic
    fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region.
    Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005100Rho GTPase activator activity IEA--
    GO:0005515protein binding IPI11432776
    GO:0005543phospholipid binding IEA--
         
    ARHGAP10 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidARHGAP10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Apoptosis0.39
    2Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    3Signaling by GPCR
    Signal Transduction0.55
    4Regulation of PAK-2p34 activity by PS-GAP/RHG10
    Regulation of PAK-2p34 activity by PS-GAP/RHG100.33
    5Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for ARHGAP10 (see all 6)
        Regulation of Apoptosis
    Signaling by Rho GTPases
    Regulation of PAK-2p34 activity by PS-GAP/RHG10
    Signal Transduction
    Rho GTPase cycle


    1         Kegg Pathway  (Kegg details for ARHGAP10):
        Bacterial invasion of epithelial cells


    ARHGAP10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ARHGAP10 (A1A4S61, 3 ENSP000003369234) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKN3Q6P5Z21, 3, ENSP000002919064EBI-1390944,EBI-1384335 I2D: score=3 STRING: ENSP00000291906
    PAK2Q131773, ENSP000003140674I2D: score=1 STRING: ENSP00000314067
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    PKN1Q165123, ENSP000003433254I2D: score=1 STRING: ENSP00000343325
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007010cytoskeleton organization IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032321positive regulation of Rho GTPase activity ----

    ARHGAP10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP10 (RHG10)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP10 / RHG10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP10 gene: 
    NM_024605.3  

    Unigene Cluster for ARHGAP10:

    Rho GTPase activating protein 10
    Hs.368631  [show with all ESTs]
    Unigene Representative Sequence: NM_024605
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510379(uc003ile.1) ENST00000336498(uc003ilf.3 uc003ilg.3)
    ENST00000506054 ENST00000507661 ENST00000506020(uc003ilh.3 uc003ili.3)
    ENST00000513548 ENST00000510076 ENST00000414545
    miRNA
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    hsa-miR-579 hsa-miR-214 hsa-miR-204 hsa-miR-205* hsa-miR-761 hsa-miR-211
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    Additional mRNA sequence: 

    AB050785.1 AK024549.1 AK096041.1 AK123034.1 AK304458.1 AL834360.1 BC011920.2 BC047914.1 
    BC106018.1 BC109029.2 BC109030.1 BC126899.1 BC128055.1 CR457328.1 

    8 DOTS entries:

    DT.112671  DT.100025867  DT.95367758  DT.99965208  DT.91674823  DT.99971384  DT.95367757  DT.101963030 

    24/61 AceView cDNA sequences (see all 61):

    AW139688 CB126525 AI167698 AA307147 BP381705 BF773310 BM717959 AI571949 
    CD245739 CF272304 AI245305 AI357709 CA449757 BQ013751 AA486536 BG281975 
    CA442818 BI093467 AA872017 AI085546 CA432119 AA872016 BU679645 BU633780 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:                                                                    -                             -                                       
    SP2:                                                                    -                             -                                       
    SP3:                                                                    -                             -                 -     -               
    SP4:                                                                                                  -                                       
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ARHGAP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP10 expression in normal human tissues (normalized intensities)      ARHGAP10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGATTTT
    ARHGAP10 Expression
    About this image


    ARHGAP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Placenta (Extraembryonic Tissues)

    See ARHGAP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP10

    SOURCE GeneReport for Unigene cluster: Hs.368631

    UniProtKB/Swiss-Prot: RHG10_HUMAN, A1A4S6
    Tissue specificity: High levels of expression in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARHGAP10 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap101 , 5 Rho GTPase activating protein 101, 5 86.9(n)1
    91.48(a)1
      8 (36.60 cM)5
    785141  NM_030113.21  NP_084389.21 
     772503665 
    chicken
    (Gallus gallus)
    Aves ARHGAP101 Rho GTPase activating protein 10 77.19(n)
    81.13(a)
      422471  XM_001232914.2  XP_001232915.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP106
    Rho GTPase activating protein 10
    79(a)
    1 ↔ 1
    5(133922213-134069772)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183592 Xenopus laevis transcribed sequence with weak similarity more 77.38(n)    BJ621340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgap101 Rho GTPase activating protein 10 64.23(n)
    64.36(a)
      692277  NM_001045250.1  NP_001038715.1 


    ENSEMBL Gene Tree for ARHGAP10 (if available)
    TreeFam Gene Tree for ARHGAP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP10 gene
    ARHGAP212  ARHGAP272  ARHGAP322  CHN22  ARHGAP232  ARHGAP332  ARHGAP92  ARHGAP262  
    CHN12  ARHGAP302  ARHGAP152  ARHGAP122  OPHN12  ARHGAP422  ARHGAP312  
    17 SIMAP similar genes for ARHGAP10 using alignment to 5 protein entries:     RHG10_HUMAN (see all proteins):
    GRAF    DKFZp667D142    FLJ20896    OPHN1    ARHGAP12    CHN2
    CHN1    SH3GL2    ARHGAP26    ARHGAP21    ARHGAP31    ARHGAP24
    ARHGEF7    ARHGAP42    ARHGAP23    ITSN1    ARHGAP9

    ARHGAP10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6817 SNPs in ARHGAP10 are shown (see all 6817)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009358171,2
    Cuntested1148827800(+) CGTTTC/G/TCTTGA 2 S F mis11EU 1323
    rs1838470281,2
    --148651630(+) TAGTAA/GGAACT 1 -- us2k10--------
    rs1493637361,2
    C--148651744(+) TGTTTC/TGTAAC 1 -- us2k10--------
    rs729514291,2
    C,F--148651763(+) TTATTG/TAGTAG 1 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1446752161,2
    C--148651896(+) TTACCA/TTCATA 1 -- us2k10--------
    rs1876497681,2
    --148651920(+) TATCGC/TGAGTT 1 -- us2k10--------
    rs1394222891,2
    --148651958(+) GCCCGA/GCACAT 1 -- us2k10--------
    rs1483296101,2
    C--148652018(+) TAGTG-/TTTTTT 1 -- us2k10--------
    rs106667041,2
    C--148652036(+) TTTTT-/TT/TTT
            
    GAGAC
    2 -- us2k1 cds11NA 2
    rs1919975701,2
    --148652149(+) TGCCTC/TAGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGAP10 (148653214 - 148903214 bp, first 250kb of ARHGAP10)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ARHGAP10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv292987CNV Insertion16902084
    dgv5780n71CNV Loss21882294
    nsv880242CNV Gain21882294
    esv274865CNV Gain+Loss21479260
    esv259874OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609746    OMIM disorders: --

    3 diseases for ARHGAP10:    About MalaCards
    hypertrichosis    smallpox    spasticity


    ARHGAP10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGAP10
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP10 (4 documents)

    Export disorders for ARHGAP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP10 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGAP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    3. A genome-wide association study of prognosis in breas t cancer. (PubMed id 20332263)1, 4 Azzato E.M....Kraft P. (2010)
    4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1, 4 Marroni F....Pramstaller P.P. (2009)
    5. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. (PubMed id 11432776)1, 2 Shibata H.... Ono Y. (2001)
    6. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PubMed id 8288572)1, 3 Lancaster C.A....Hall A. (1994)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. A genomewide association study of nicotine and alcoho l dependence in Australian and Dutch populations. (PubMed id 20158304)1 Lind P.A....Madden P.A. (2010)
    10. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79658 HGNC: 26099 AceView: ARHGAP10.1 Ensembl:ENSG00000071205 euGenes: HUgn79658
    ECgene: ARHGAP10 Kegg: 79658 H-InvDB: ARHGAP10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP10 gene:
    Search GeneIP for patents involving ARHGAP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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