Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGAP1 Gene

protein-coding   GIFtS: 65
GCID: GC11M046698

Rho GTPase Activating Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GTPase Activating Protein 11 2     RHOGAP2
CDC42GAP2 3 5     GTPase-Activating Protein RhoGAP2
RHOGAP12 3 5     GTPase-Activating Protein, Rho, 12
Rho-Related Small GTPase Protein Activator2 3     p50rhoGAP2
Rho-Type GTPase-Activating Protein 12 3     Rho GTPase-Activating Protein 12
CDC42 GTPase-Activating Protein2 3     p50-RhoGAP3
GTPase-Activating Protein RhoOGAP2 3     

External Ids:    HGNC: 6731   Entrez Gene: 3922   Ensembl: ENSG000001752207   OMIM: 6027325   UniProtKB: Q079603   

Export aliases for ARHGAP1 gene to outside databases

Previous GC identifers: GC11M048679 GC11M047576 GC11M046730 GC11M046662 GC11M046655 GC11M046404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP1 Gene:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP)
metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated
protein family members. (provided by RefSeq, Aug 2012)

GeneCards Summary for ARHGAP1 Gene: 
ARHGAP1 (Rho GTPase activating protein 1) is a protein-coding gene. Diseases associated with ARHGAP1 include oculocerebrorenal syndrome, and nephrogenic diabetes insipidus, and among its related super-pathways are Signaling by Rho GTPases and Actin Nucleation and Branching. GO annotations related to this gene include Rho GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP17.

UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive
GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Wiki entry for ARHGAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP1 gene promoter:
         CREB   PPAR-gamma1   AP-1   deltaCREB   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ARHGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M046698:  view genomic region     (about GC identifiers)

Start:
46,698,630 bp from pter      End:
46,722,165 bp from pter
Size:
23,536 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 1  
Size: 439 amino acids; 50436 Da
Subunit: Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA16142.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for ARHGAP1:
1AM4 (3D)        1GRN (3D)        1OW3 (3D)        1RGP (3D)        1TX4 (3D)        2NGR (3D)    
Secondary accessions: D3DQQ6

Explore the universe of human proteins at neXtProt for ARHGAP1: NX_Q07960

Explore proteomics data for ARHGAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07960

  • ARHGAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGAP1 Protein Expression
    REFSEQ proteins: NP_004299.1  
    ENSEMBL proteins: 
     ENSP00000310491   ENSP00000434883   ENSP00000432794  
    Reactome Protein details: Q07960
    Human Recombinant Protein Products for ARHGAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARHGAP1
    OriGene Protein Over-expression Lysate for ARHGAP1
    OriGene MassSpec for ARHGAP1 
    OriGene Custom Protein Services for ARHGAP1
    GenScript Custom Purified and Recombinant Proteins Services for ARHGAP1
    Novus Biologicals ARHGAP1 Protein
    Novus Biologicals ARHGAP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGAP1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031252cell leading edge ----

    ARHGAP1 for ontologies           About GeneDecksing



    ARHGAP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARHGAP1
    R&D Systems Antibodies for ARHGAP1
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARHGAP1
    GenScript Custom Superior Antibodies Services for ARHGAP1
    Novus Biologicals ARHGAP1 Antibodies
    Abcam antibodies for ARHGAP1
    Cloud-Clone Corp. Antibodies for ARHGAP1 
    ThermoFisher Antibody for ARHGAP1
    LSBio Antibodies in human, mouse, rat for ARHGAP1 

    Assay Products for ARHGAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGAP1 
    Cloud-Clone Corp. CLIAs for ARHGAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001251 CRAL-TRIO_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q07960

    ProtoNet protein and cluster: Q07960

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)


    UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 Rho-GAP domain


    ARHGAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG01_HUMAN, Q07960
    Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive
    GDP-bound state. Cdc42 seems to be the preferred substrate

         Genatlas biochemistry entry for ARHGAP1:
    Rho/CDC42 GTPase activating protein 1,ubiquitously expressed

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8253717
    GO:0005100Rho GTPase activator activity IDA8253717
    GO:0005515protein binding IPI11927263
    GO:0017124SH3 domain binding IEA--
    GO:0030675Rac GTPase activator activity IEA--
         
    ARHGAP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARHGAP1:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap1):
     adipose tissue  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  renal/urinary system  reproductive system  skeleton 

    ARHGAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgap1tm1Yizh for ARHGAP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGAP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP1 (see all 42):
    hsa-miR-106a hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-650 hsa-miR-449a hsa-miR-4267 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGAP1
    Sirion Biotech Customized adenovirus for overexpression of ARHGAP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARHGAP1 (see all 8)
    OriGene ORF clones in mouse, rat for ARHGAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP1 (NM_004308)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP1
    Sirion Biotech Customized lentivirus for stable overexpression of ARHGAP1 
                         Customized lentivirus expression plasmids for stable overexpression of ARHGAP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGAP1
    Search LifeMap BioReagents cell lines for ARHGAP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGAP1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    2Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    RhoA Pathway0.35
    3G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    4Signaling by GPCR
    Signal Transduction0.55
    5G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for ARHGAP1
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGAP1
        RhoA Pathway
    G12-G13 in Cellular Signaling
    RhoGDI Pathway
    CDC42 Pathway

    3 GeneGo (Thomson Reuters) Pathways for ARHGAP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    2 BioSystems Pathways for ARHGAP1
        Regulation of CDC42 activity
    Regulation of RAC1 activity

    3        Reactome Pathways for ARHGAP1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    ARHGAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for ARHGAP1 (Q079601, 2, 3 ENSP000003104914) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3, ENSP000004001754EBI-602762,EBI-446668 MINT-68456 I2D: score=7 STRING: ENSP00000400175
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    CDC42P609531, 3, ENSP000003144584EBI-602762,EBI-81752 I2D: score=6 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS8253717
    GO:0032321positive regulation of Rho GTPase activity ----
    GO:0032855positive regulation of Rac GTPase activity ----

    ARHGAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARHGAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP1 (RHG01)

    6 Novoseek inferred chemical compound relationships for ARHGAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 67.5 10 16784226 (2), 9338791 (2), 9548756 (2), 12501193 (1) (see all 6)
    gdp 56.6 5 9338791 (2), 10555980 (1), 9548756 (1), 17272280 (1)
    arginine 30.1 6 12454018 (2), 12501193 (1), 9846874 (1), 9893994 (1) (see all 5)
    fluoride 10.6 4 10555980 (2), 9893994 (2)
    tyrosine 9.85 3 12788081 (1), 12454018 (1), 11238453 (1)
    magnesium 0 1 9548756 (1)

    Search CenterWatch for drugs/clinical trials and news about ARHGAP1 / RHG01

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGAP1 gene: 
    NM_004308.3  

    Unigene Cluster for ARHGAP1:

    Rho GTPase activating protein 1
    Hs.138860  [show with all ESTs]
    Unigene Representative Sequence: NM_004308
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311956(uc001ndd.3) ENST00000526423 ENST00000528837 ENST00000525488
    ENST00000527588(uc009yle.1) ENST00000529960 ENST00000524594(uc009ylf.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGAP1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGAP1 (see all 42):
    hsa-miR-106a hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-650 hsa-miR-449a hsa-miR-4267 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGAP1 (see all 8)
    OriGene ORF clones in mouse, rat for ARHGAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGAP1 (NM_004308)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP1
    Sirion Biotech Customized lentivirus for stable overexpression of ARHGAP1 
                         Customized lentivirus expression plasmids for stable overexpression of ARHGAP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARHGAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP1

    Additional mRNA sequence: 

    AK126404.1 AK298562.1 AK307296.1 AK310605.1 BC018118.1 U02570.1 U62794.1 Z23024.1 

    16 DOTS entries:

    DT.85104680  DT.97863725  DT.207853  DT.85104681  DT.92437304  DT.100780579  DT.100780581  DT.120751088 
    DT.120751096  DT.120751099  DT.91975067  DT.92437297  DT.99994218  DT.100730095  DT.95219439  DT.97794661 

    24/291 AceView cDNA sequences (see all 291):

    R63309 BQ027035 CA417795 BQ030393 AI826515 BM876170 Z23024 BQ229167 
    NM_004308 BQ267905 H42474 U02570 AJ346003 BU077641 BM681970 BQ005767 
    BM511692 BU740030 CD370332 R63303 BM708950 BU731610 BX364907 BM721831 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                    -     -     -     -                 -     -           -     -     -                                               -                     
    SP2:                                                                                                                                                            
    SP3:                                                        -     -           -     -     -                                                                     
    SP4:                                -     -                 -     -           -     -     -                                                                     
    SP5:                    -     -     -     -                 -     -                                                                                             

    ExUns: 14b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ARHGAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTCACCG
    ARHGAP1 Expression
    About this image


    See ARHGAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGAP1

    SOURCE GeneReport for Unigene cluster: Hs.138860

    UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ARHGAP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARHGAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGAP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap11 , 5 Rho GTPase activating protein 11, 5 89.37(n)1
    96.58(a)1
      2 (50.63 cM)5
    2283591  NM_001145902.11  NP_001139374.11 
     916498605 
    chicken
    (Gallus gallus)
    Aves ARHGAP11 Rho GTPase activating protein 1 76.53(n)
    82.52(a)
      428865  XM_426422.3  XP_426422.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP16
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(43045917-43077830)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044312.12   -- 76.57(n)    BC044312.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI428602.12   -- 78.2(n)    BI428602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP68F1 , 3 Rho GTPase activator3
    CG6811-PA1
    37(a)3
    50.43(n)1
    36.17(a)1
      393851  NM_140295.21  NP_648552.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.83
    rga-11
    GTPase-activating (rhoGAP) like protein3
    Protein RGA-11
    39(a)3
    50.42(n)1
    41.5(a)1
      II(11464575-11466218)3
    1747511  NM_001027219.41  NP_001022390.11 


    ENSEMBL Gene Tree for ARHGAP1 (if available)
    TreeFam Gene Tree for ARHGAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGAP1 gene
    ARHGAP172  ARHGAP52  SRGAP12  ARHGAP242  ARHGAP222  SRGAP32  ARHGAP352  ARHGAP82  
    ARHGAP442  PRR5-ARHGAP82  SH3BP12  ARHGAP252  SRGAP22  ARHGAP42  
    14 SIMAP similar genes for ARHGAP1 using alignment to 3 protein entries:     RHG01_HUMAN (see all proteins):
    BPGAP1    ARHGAP8    LOC553158    PRR5-ARHGAP8    FAM13B    ARHGAP12
    FAM13A    CHN2    ARHGAP5    ARHGAP24    ARHGAP9    BNIP2
    PRUNE2    ARHGAP21

    ARHGAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/511 SNPs in ARHGAP1 are shown (see all 511)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398020101,2
    --46404177(+) GAACCA/GTCTTC 1 -- ds50010--------
    rs1932073511,2
    --46404238(+) CGGTGA/CGAGCT 1 -- ds50010--------
    rs1852197931,2
    --46404372(+) CTTCCA/GGTACC 1 -- ds50010--------
    rs1902140321,2
    --46404399(+) GGAGAA/GGCCCT 1 -- ds50010--------
    rs1444936551,2
    --46404524(+) CACTCC/GAGTGC 1 -- ds50010--------
    rs1487711661,2
    --46404537(+) AAGATA/GAGGAA 1 -- ds50010--------
    rs1814648551,2
    --46404654(+) CCCCAA/TCATCC 1 -- ds50010--------
    rs1848095581,2
    --46404684(+) AACATC/TTTTAT 1 -- ut310--------
    rs786556361,2
    C,F--46404863(+) GGGCTG/ATGAGC 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1884038971,2
    --46404888(+) AAAGGA/CGGGCG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGAP1 (46698630 - 46722165 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGAP1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602732    OMIM disorders: --

    20 diseases for ARHGAP1:    About MalaCards
    oculocerebrorenal syndrome    nephrogenic diabetes insipidus    brain cancer    fanconi syndrome
    noma    diabetes insipidus    microphthalmia    wiskott-aldrich syndrome
    intellectual disability    chronic myeloid leukemia    transitional cell carcinoma    hepatocellular carcinoma
    spasticity    mental retardation    myeloid leukemia    ovarian cancer
    lung cancer    squamous cell carcinoma    leukemia    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for ARHGAP1:
    Fanconi syndrome     Intellectual disability

    ARHGAP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for ARHGAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 39.3 5 18374170 (1), 19487570 (1), 19481455 (1), 9582072 (1) (see all 5)
    hepatocellular carcinoma 19.5 1 19440389 (1)
    tumors 0 9 17932950 (2), 16204057 (2), 17517630 (1), 19158340 (1) (see all 7)
    cancer 0 2 19440389 (1), 19151751 (1)

    Genetic Association Database (GAD): ARHGAP1
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP1 (2 documents)

    Export disorders for ARHGAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGAP1 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with ARHGAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PubMed id 8288572)1, 2, 3, 9 Lancaster C.A....Hall A. (1994)
    2. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PubMed id 12901880)1, 2, 9 Qin W.... Gu J. (2003)
    3. The structure of the GTPase-activating domain from p50rhoGAP. (PubMed id 9009196)1, 2, 9 Barrett T....Eccleston J.F. (1997)
    4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    5. Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (2009)
    6. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2 Mingot J.-M.... Goerlich D. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Crystal structure of a small G protein in complex with the GTPase- activating protein rhoGAP. (PubMed id 9262406)1, 2 Rittinger K.... Smerdon S.J. (1997)
    9. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. (PubMed id 8253717)1, 2 Barfod E.T....Ashkenazi A. (1993)
    10. Bcr encodes a GTPase-activating protein for p21rac. (PubMed id 1903516)1, 2 Diekmann D.... Hall A. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 392 HGNC: 673 AceView: ARHGAP1 Ensembl:ENSG00000175220 euGenes: HUgn392
    ECgene: ARHGAP1 H-InvDB: ARHGAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGAP1 gene:
    Search GeneIP for patents involving ARHGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ARHGAP1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ARHGAP1 (ARHGAP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARHGAP1  
     OriGene qPCR primer pairs and template standards for ARHGAP1   OriGene Protein Over-expression Lysate for ARHGAP1  
     OriGene MassSpec something-or-other for ARHGAP1   OriGene clones in human, mouse for ARHGAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGAP1   OriGene Purified Protein for ARHGAP1  
     OriGene ORF clones in mouse, rat for ARHGAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGAP1   OriGene Custom Protein Services for ARHGAP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGAP1
     QIAGEN SeqTarget long-range PCR primers for resequencing ARHGAP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGAP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGAP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGAP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGAP1
     GenScript Custom Purified and Recombinant Proteins Services for ARHGAP1 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGAP1
     GenScript Custom Assay Services for ARHGAP1 GenScript Custom Superior Antibodies Services for ARHGAP1
     GenScript Custom overexpressing Cell Line Services for ARHGAP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARHGAP1 promoter
     Search Chromatin IP Primers for ARHGAP1
     RT2 qPCR Primer Assay in human, mouse, rat ARHGAP1
     GNC Network for ARHGAP1
     SABiosciences PCR Arrays including human, mouse, rat ARHGAP1
     Search Tocris compounds for ARHGAP1 (RHG01)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARHGAP1 antibodies
     ARHGAP1 proteins
     ARHGAP1 lysates
     Antibodies for ARHGAP1
     See all of Abcam's Antibodies, Kits and Proteins for ARHGAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARHGAP1
     Antibodies for ARHGAP1
     ELISAs for ARHGAP1
     CLIAs for ARHGAP1
     Search LifeMap BioReagents cell lines for ARHGAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGAP1
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGAP1
     SwitchGear Promoter luciferase reporter plasmids for ARHGAP1
     ThermoFisher Antibody for ARHGAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGAP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGAP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGAP1
    Customized:
     lentivirus for stable overexpression of ARHGAP1
     lentivirus expression plasmids for stable overexpression of ARHGAP1
     adenovirus for overexpression of ARHGAP1
     LSBio Antibodies in human, mouse, rat for ARHGAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGAP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4