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ARHGAP1 Gene

protein-coding   GIFtS: 66
GCID: GC11M046698

Rho GTPase Activating Protein 1

  See ARHGAP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GTPase Activating Protein 11 2     RHOGAP2
CDC42GAP2 3 5     GTPase-Activating Protein RhoGAP2
RHOGAP12 3 5     GTPase-Activating Protein, Rho, 12
Rho-Related Small GTPase Protein Activator2 3     p50rhoGAP2
Rho-Type GTPase-Activating Protein 12 3     Rho GTPase-Activating Protein 12
CDC42 GTPase-Activating Protein2 3     p50-RhoGAP3
GTPase-Activating Protein RhoOGAP2 3     

External Ids:    HGNC: 6731   Entrez Gene: 3922   Ensembl: ENSG000001752207   OMIM: 6027325   UniProtKB: Q079603   

Export aliases for ARHGAP1 gene to outside databases

Previous GC identifers: GC11M048679 GC11M047576 GC11M046730 GC11M046662 GC11M046655 GC11M046404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGAP1 Gene:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP)
metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated
protein family members. (provided by RefSeq, Aug 2012)

GeneCards Summary for ARHGAP1 Gene:
ARHGAP1 (Rho GTPase activating protein 1) is a protein-coding gene. Diseases associated with ARHGAP1 include noma. GO annotations related to this gene include Rho GTPase activator activity and SH3 domain binding. An important paralog of this gene is BNIP2.

UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive
GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Wiki entry for ARHGAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGAP1 gene promoter:
         CREB   PPAR-gamma1   AP-1   deltaCREB   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGAP1 promoter sequence
   Search Chromatin IP Primers for ARHGAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ARHGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M046698:  view genomic region     (about GC identifiers)

Start:
46,698,630 bp from pter      End:
46,722,165 bp from pter
Size:
23,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 1  
Size: 439 amino acids; 50436 Da
Subunit: Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL
Sequence caution: Sequence=AAA16142.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for ARHGAP1:
1AM4 (3D)        1GRN (3D)        1OW3 (3D)        1RGP (3D)        1TX4 (3D)        2NGR (3D)    
Secondary accessions: D3DQQ6

Explore the universe of human proteins at neXtProt for ARHGAP1: NX_Q07960

Explore proteomics data for ARHGAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys212
  • Modification sites at PhosphoSitePlus

  • See ARHGAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004299.1  
    ENSEMBL proteins: 
     ENSP00000310491   ENSP00000434883   ENSP00000432794  
    Reactome Protein details: Q07960

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR001251 CRAL-TRIO_dom
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q07960

    ProtoNet protein and cluster: Q07960

    2 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)


    UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with ARHGAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHG01_HUMAN, Q07960
    Function: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive
    GDP-bound state. Cdc42 seems to be the preferred substrate

         Genatlas biochemistry entry for ARHGAP1:
    Rho/CDC42 GTPase activating protein 1,ubiquitously expressed

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8253717
    GO:0005100Rho GTPase activator activity IDA8253717
    GO:0005515protein binding IPI11927263
    GO:0017124SH3 domain binding IEA--
    GO:0030675Rac GTPase activator activity IEA--
         
    Find genes that share ontologies with ARHGAP1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARHGAP1:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgap1):
     adipose tissue  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with ARHGAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgap1tm1Yizh for ARHGAP1

       genOway: Develop your customized and physiologically relevant rodent model for ARHGAP1

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    hsa-mir-34a-5p (MIRT025280), hsa-mir-130b-3p (MIRT020316), hsa-mir-19b-3p (MIRT031242), hsa-mir-93-5p (MIRT028087)

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGAP1 (see all 42):
    hsa-miR-106a hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-650 hsa-miR-449a hsa-miR-4267 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGAP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHG01_HUMAN, Q07960: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    golgi apparatus2
    nucleus2
    plasma membrane2
    endosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031252cell leading edge ----

    Find genes that share ontologies with ARHGAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGAP1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    RhoA Pathway0.35
    3Signaling by GPCR
    Signal Transduction0.58
    4RhoGDI Pathway
    RhoGDI Pathway0.33
    5Regulation of RAC1 activity
    Regulation of RAC1 activity


    Find genes that share SuperPaths with ARHGAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGAP1
        RhoA Pathway
    G12-G13 in Cellular Signaling
    RhoGDI Pathway
    CDC42 Pathway

    3 GeneGo (Thomson Reuters) Pathways for ARHGAP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    2 BioSystems Pathways for ARHGAP1
        Regulation of CDC42 activity
    Regulation of RAC1 activity


    1 Reactome Pathway for ARHGAP1
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGAP1
    Interactions:

        GeneGlobe Interaction Network for ARHGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGAP1 (Q079601, 2, 3 ENSP000003104914) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3, ENSP000004001754EBI-602762,EBI-446668 MINT-68456 I2D: score=7 STRING: ENSP00000400175
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    CDC42P609531, 3, ENSP000003144584EBI-602762,EBI-81752 I2D: score=6 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS8253717
    GO:0009967positive regulation of signal transduction TAS8253717
    GO:0032321positive regulation of Rho GTPase activity ----

    Find genes that share ontologies with ARHGAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGAP1 (RHG01)

    6 Novoseek inferred chemical compound relationships for ARHGAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 67.5 10 16784226 (2), 9338791 (2), 9548756 (2), 12501193 (1) (see all 6)
    gdp 56.6 5 9338791 (2), 10555980 (1), 9548756 (1), 17272280 (1)
    arginine 30.1 6 12454018 (2), 12501193 (1), 9846874 (1), 9893994 (1) (see all 5)
    fluoride 10.6 4 10555980 (2), 9893994 (2)
    tyrosine 9.85 3 12788081 (1), 12454018 (1), 11238453 (1)
    magnesium 0 1 9548756 (1)



    Find genes that share compounds with ARHGAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGAP1 gene: 
    NM_004308.3  

    Unigene Cluster for ARHGAP1:

    Rho GTPase activating protein 1
    Hs.138860  [show with all ESTs]
    Unigene Representative Sequence: NM_004308
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311956(uc001ndd.3) ENST00000526423 ENST00000528837 ENST00000525488
    ENST00000527588(uc009yle.1) ENST00000529960 ENST00000524594(uc009ylf.1)

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    hsa-miR-106a hsa-miR-301a hsa-miR-486-3p hsa-miR-519a hsa-miR-650 hsa-miR-449a hsa-miR-4267 hsa-miR-93
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    Additional mRNA sequence: 

    AK126404.1 AK298562.1 AK307296.1 AK310605.1 BC018118.1 U02570.1 U62794.1 Z23024.1 

    16 DOTS entries:

    DT.85104680  DT.97863725  DT.207853  DT.85104681  DT.92437304  DT.100780579  DT.100780581  DT.120751088 
    DT.120751096  DT.120751099  DT.91975067  DT.92437297  DT.99994218  DT.100730095  DT.95219439  DT.97794661 

    Selected AceView cDNA sequences (see all 291):

    NM_004308 H44217 BX364907 R63309 BU731610 BM681970 AI826515 BM876179 
    BQ030393 H42474 CA417795 BM876170 BQ229167 BU859034 BM721831 R63303 
    BQ671698 BM894250 AA147879 BM511692 BQ005767 BQ267905 BQ182091 U02570 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                    -     -     -     -                 -     -           -     -     -                                               -                     
    SP2:                                                                                                                                                            
    SP3:                                                        -     -           -     -     -                                                                     
    SP4:                                -     -                 -     -           -     -     -                                                                     
    SP5:                    -     -     -     -                 -     -                                                                                             

    ExUns: 14b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ARHGAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTCACCG
    ARHGAP1 Expression
    About this image

    ARHGAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.138860

    UniProtKB/Swiss-Prot: RHG01_HUMAN, Q07960
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGAP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgap11 , 5 Rho GTPase activating protein 11, 5 89.37(n)1
    96.58(a)1
      2 (50.63 cM)5
    2283591  NM_001145902.11  NP_001139374.11 
     916498605 
    chicken
    (Gallus gallus)
    Aves ARHGAP11 Rho GTPase activating protein 1 76.46(n)
    82.28(a)
      428865  XM_004941591.1  XP_004941648.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGAP16
    Rho GTPase activating protein 1
    77(a)
    1 ↔ 1
    1(43045917-43077830)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044312.12   -- 76.57(n)    BC044312.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI428602.12   -- 78.2(n)    BI428602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP68F1 , 3 Rho GTPase activator3
    RhoGAP68F1
    37(a)3
    54.31(n)1
    41.09(a)1
      393851  NM_001274816.11  NP_001261745.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.83
    rga-11
    GTPase-activating (rhoGAP) like protein3
    rga-11
    39(a)3
    50.32(n)1
    41.23(a)1
      II(11464575-11466218)3
    1747511  NM_001027219.51  NP_001022390.11 


    ENSEMBL Gene Tree for ARHGAP1 (if available)
    TreeFam Gene Tree for ARHGAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGAP1 gene
    BNIP22  PRUNE22  ARHGAP82  ATCAY2  PRR5-ARHGAP82  BNIPL2  
    14 SIMAP similar genes for ARHGAP1 using alignment to 3 protein entries:     RHG01_HUMAN (see all proteins):
    BPGAP1    ARHGAP8    LOC553158    PRR5-ARHGAP8    FAM13B    ARHGAP12
    FAM13A    CHN2    ARHGAP5    ARHGAP24    ARHGAP9    BNIP2
    PRUNE2    ARHGAP21

    Find genes that share paralogs with ARHGAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ARHGAP1 (see all 511)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398020101,2
    --46404177(+) GAACCA/GTCTTC 1 -- ds50010--------
    rs1932073511,2
    --46404238(+) CGGTGA/CGAGCT 1 -- ds50010--------
    rs1852197931,2
    --46404372(+) CTTCCA/GGTACC 1 -- ds50010--------
    rs1902140321,2
    --46404399(+) GGAGAA/GGCCCT 1 -- ds50010--------
    rs1444936551,2
    --46404524(+) CACTCC/GAGTGC 1 -- ds50010--------
    rs1487711661,2
    --46404537(+) AAGATA/GAGGAA 1 -- ds50010--------
    rs1814648551,2
    --46404654(+) CCCCAA/TCATCC 1 -- ds50010--------
    rs1848095581,2
    --46404684(+) AACATC/TTTTAT 1 -- ut310--------
    rs786556361,2
    C,F--46404863(+) GGGCTG/ATGAGC 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1884038971,2
    --46404888(+) AAAGGA/CGGGCG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGAP1 (46698630 - 46722165 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGAP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602732    OMIM disorders: --

    1 disease for ARHGAP1:    
    About MalaCards
    noma

    2 diseases from the University of Copenhagen DISEASES database for ARHGAP1:
    Fanconi syndrome     Intellectual disability

    Find genes that share disorders with ARHGAP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for ARHGAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 39.3 5 18374170 (1), 19487570 (1), 19481455 (1), 9582072 (1) (see all 5)
    hepatocellular carcinoma 19.5 1 19440389 (1)
    tumors 0 9 17932950 (2), 16204057 (2), 17517630 (1), 19158340 (1) (see all 7)
    cancer 0 2 19440389 (1), 19151751 (1)

    Genetic Association Database (GAD): ARHGAP1
    Human Genome Epidemiology (HuGE) Navigator: ARHGAP1 (2 documents)

    Export disorders for ARHGAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGAP1 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with ARHGAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PubMed id 8288572)1, 2, 3, 9 Lancaster C.A....Hall A. (J. Biol. Chem. 1994)
    2. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PubMed id 12901880)1, 2, 9 Qin W.... Gu J. (Biochem. Biophys. Res. Commun. 2003)
    3. The structure of the GTPase-activating domain from p50rhoGAP. (PubMed id 9009196)1, 2, 9 Barrett T....Eccleston J.F. (Nature 1997)
    4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (Nat. Genet. 2009)
    6. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2 Mingot J.-M.... Goerlich D. (EMBO J. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Crystal structure of a small G protein in complex with the GTPase- activating protein rhoGAP. (PubMed id 9262406)1, 2 Rittinger K.... Smerdon S.J. (Nature 1997)
    9. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. (PubMed id 8253717)1, 2 Barfod E.T....Ashkenazi A. (J. Biol. Chem. 1993)
    10. Bcr encodes a GTPase-activating protein for p21rac. (PubMed id 1903516)1, 2 Diekmann D.... Hall A. (Nature 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 392 HGNC: 673 AceView: ARHGAP1 Ensembl:ENSG00000175220 euGenes: HUgn392
    ECgene: ARHGAP1 H-InvDB: ARHGAP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGAP1 gene:
    Search GeneIP for patents involving ARHGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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