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Aliases for ARHGAP1 Gene

Aliases for ARHGAP1 Gene

  • Rho GTPase Activating Protein 1 2 3 5
  • Rho-Related Small GTPase Protein Activator 3 4
  • Rho-Type GTPase-Activating Protein 1 3 4
  • GTPase-Activating Protein RhoGAP 3 4
  • CDC42 GTPase-Activating Protein 3 4
  • CDC42GAP 3 4
  • RHOGAP1 3 4
  • GTPase-Activating Protein RhoOGAP 3
  • GTPase-Activating Protein, Rho, 1 3
  • Rho GTPase-Activating Protein 1 3
  • P50-RhoGAP 4
  • P50rhoGAP 3
  • RHOGAP 3

External Ids for ARHGAP1 Gene

Previous GeneCards Identifiers for ARHGAP1 Gene

  • GC11M048679
  • GC11M047576
  • GC11M046730
  • GC11M046662
  • GC11M046655
  • GC11M046404
  • GC11M046698
  • GC11M047080
  • GC11M047925
  • GC11M050781
  • GC11M051576

Summaries for ARHGAP1 Gene

Entrez Gene Summary for ARHGAP1 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

GeneCards Summary for ARHGAP1 Gene

ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include Noma and Fanconi Renotubular Syndrome 1. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is PRR5-ARHGAP8.

UniProtKB/Swiss-Prot for ARHGAP1 Gene

  • GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Gene Wiki entry for ARHGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP1 Gene

Genomics for ARHGAP1 Gene

Regulatory Elements for ARHGAP1 Gene

Enhancers for ARHGAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F046699 1.2 ENCODE 14.2 -0.2 -207 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SNORD67 LOC105376662 LOC101928894 LOC105376659 ARHGAP1 KBTBD4 RPS10P19 LOC100507384 PACSIN3 MDK
GH11F046669 1.2 Ensembl ENCODE 10.9 +27.2 27193 8.3 PKNOX1 MLX ARID4B YY1 SLC30A9 GLIS2 NFYC MXD4 PPARG KAT8 ENSG00000270060 RPS10P19 DDB2 ARHGAP1 LRP4 MDK C11orf49 ATG13 ENSG00000271350 GC11P046676
GH11F046597 1.2 Ensembl ENCODE 10.1 +102.9 102877 1.5 PKNOX1 ATF1 ARID4B GATA2 FOS NCOA1 PPARG MBD2 MEF2D MIER3 HARBI1 CHRM4 ARHGAP1 ZNF408 AMBRA1 ATG13
GH11F046647 0.9 Ensembl ENCODE 11.7 +51.4 51429 2.8 CTCF NFIA JUN SIN3A RAD21 ATF2 NR2F2 JUND POLR2A ZBTB48 ATG13 ARHGAP1 ZNF408 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5 LRP4
GH11F046455 1 Ensembl ENCODE 10.2 +243.7 243660 2.8 MAZ PKNOX1 MTA2 HLF CEBPB FEZF1 ZIC2 OSR2 ZNF664 ZNF121 CHRM4 ARHGAP1 ZNF408 F2 ATG13 MIR3160-1 AMBRA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGAP1 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000562060 -135 2801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ARHGAP1 Gene

Chromosome:
11
Start:
46,677,075 bp from pter
End:
46,700,665 bp from pter
Size:
23,591 bases
Orientation:
Minus strand

Genomic View for ARHGAP1 Gene

Genes around ARHGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP1 Gene

Proteins for ARHGAP1 Gene

  • Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07960-RHG01_HUMAN
    Recommended name:
    Rho GTPase-activating protein 1
    Protein Accession:
    Q07960
    Secondary Accessions:
    • D3DQQ6

    Protein attributes for ARHGAP1 Gene

    Size:
    439 amino acids
    Molecular mass:
    50436 Da
    Quaternary structure:
    • Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
    SequenceCaution:
    • Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP1 Gene

neXtProt entry for ARHGAP1 Gene

Post-translational modifications for ARHGAP1 Gene

  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP1 Gene

Antibody Products

No data available for DME Specific Peptides for ARHGAP1 Gene

Domains & Families for ARHGAP1 Gene

Suggested Antigen Peptide Sequences for ARHGAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07960

UniProtKB/Swiss-Prot:

RHG01_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP1: view

Function for ARHGAP1 Gene

Molecular function for ARHGAP1 Gene

GENATLAS Biochemistry:
Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Gene Ontology (GO) - Molecular Function for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8253717
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 9262406
GO:0017124 SH3 domain binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with ARHGAP1: view
genes like me logo Genes that share phenotypes with ARHGAP1: view

Animal Models for ARHGAP1 Gene

MGI Knock Outs for ARHGAP1:

Animal Model Products

miRNA for ARHGAP1 Gene

miRTarBase miRNAs that target ARHGAP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene

Localization for ARHGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP1: view

Pathways & Interactions for ARHGAP1 Gene

genes like me logo Genes that share pathways with ARHGAP1: view

Pathways by source for ARHGAP1 Gene

Gene Ontology (GO) - Biological Process for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IDA 8253717
GO:0007266 Rho protein signal transduction TAS 8253717
GO:0009967 positive regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGAP1: view

No data available for SIGNOR curated interactions for ARHGAP1 Gene

Drugs & Compounds for ARHGAP1 Gene

(4) Drugs for ARHGAP1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HJC 0350 Pharma 0

(3) Additional Compounds for ARHGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ARHGAP1 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARHGAP1: view

Transcripts for ARHGAP1 Gene

Unigene Clusters for ARHGAP1 Gene

Rho GTPase activating protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - -
SP9:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP1 Gene

GeneLoc Exon Structure for
ARHGAP1
ECgene alternative splicing isoforms for
ARHGAP1

Expression for ARHGAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP1 Gene



Protein tissue co-expression partners for ARHGAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP1 Gene:

ARHGAP1

SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene:

Hs.138860

mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene:

Q07960-RHG01_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ARHGAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARHGAP1 Gene

Orthologs for ARHGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP1 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia ARHGAP1 34 35
  • 91.19 (n)
cow
(Bos Taurus)
Mammalia ARHGAP1 34 35
  • 89.9 (n)
mouse
(Mus musculus)
Mammalia Arhgap1 34 16 35
  • 89.37 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP1 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap1 34
  • 87.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP1 34
  • 76.46 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap1 34
  • 73.84 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgap1 34 35
  • 63.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 36 34 35
  • 54.31 (n)
worm
(Caenorhabditis elegans)
Secernentea rga-1 34 35
  • 50.32 (n)
W02B12.8 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1565.02c 34
  • 40.04 (n)
Species where no ortholog for ARHGAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP1 Gene

ENSEMBL:
Gene Tree for ARHGAP1 (if available)
TreeFam:
Gene Tree for ARHGAP1 (if available)

Paralogs for ARHGAP1 Gene

Paralogs for ARHGAP1 Gene

(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP1: view

Variants for ARHGAP1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs796065313 Uncertain significance 46,700,834(+) TAGTC(-/GAATC)ACTGG upstream-variant-2KB, utr-variant-5-prime
rs796065314 Uncertain significance 46,700,937(+) AGGTC(A/C)AGCTC upstream-variant-2KB, utr-variant-5-prime
rs796065315 Uncertain significance 46,701,476(+) ACGTC(C/T)CACCC upstream-variant-2KB, reference, missense
rs10734547 -- 46,677,677(+) CCGGG(C/T)GCAGT utr-variant-3-prime
rs10769205 -- 46,702,053(+) ATAGT(A/G)AAGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP1 Gene

Variant ID Type Subtype PubMed ID
esv3626191 CNV gain 21293372
esv3626192 CNV loss 21293372

Variation tolerance for ARHGAP1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP1 Gene

Disorders for ARHGAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARHGAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
noma
  • cancrum oris
fanconi renotubular syndrome 1
  • fanconi-bickel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP1

Genetic Association Database (GAD)
ARHGAP1
Human Genome Epidemiology (HuGE) Navigator
ARHGAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP1
genes like me logo Genes that share disorders with ARHGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene

Publications for ARHGAP1 Gene

  1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PMID: 8288572) Lancaster C.A. … Hall A. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  3. The structure of the GTPase-activating domain from p50rhoGAP. (PMID: 9009196) Barrett T. … Eccleston J.F. (Nature 1997) 3 4 22 64
  4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  5. Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. (PMID: 19103606) Mori K. … Kaibuchi K. (J. Biol. Chem. 2009) 3 22 64

Products for ARHGAP1 Gene

Sources for ARHGAP1 Gene

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