Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP1 Gene

Aliases for ARHGAP1 Gene

  • Rho GTPase Activating Protein 1 2 3
  • Rho-Related Small GTPase Protein Activator 3 4
  • Rho-Type GTPase-Activating Protein 1 3 4
  • GTPase-Activating Protein RhoOGAP 3 4
  • Cdc42 GTPase-Activating Protein 3 4
  • CDC42GAP 3 4
  • RHOGAP1 3 4
  • GTPase-Activating Protein, Rho, 1 3
  • GTPase-Activating Protein RhoGAP 3
  • P50-RhoGAP 4
  • P50rhoGAP 3
  • RHOGAP 3

External Ids for ARHGAP1 Gene

Previous GeneCards Identifiers for ARHGAP1 Gene

  • GC11M048679
  • GC11M047576
  • GC11M046730
  • GC11M046662
  • GC11M046655
  • GC11M046404
  • GC11M046698
  • GC11M047080

Summaries for ARHGAP1 Gene

Entrez Gene Summary for ARHGAP1 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

GeneCards Summary for ARHGAP1 Gene

ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include auditory agnosia and noma. Among its related pathways are Signaling by GPCR and RhoGDI Pathway. GO annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is BNIP2.

UniProtKB/Swiss-Prot for ARHGAP1 Gene

  • GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Wiki entry for ARHGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP1 Gene

Genomics for ARHGAP1 Gene

Regulatory Elements for ARHGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP1 Gene

Chromosome:
11
Start:
46,677,075 bp from pter
End:
46,700,665 bp from pter
Size:
23,591 bases
Orientation:
Minus strand

Genomic View for ARHGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP1 Gene

Proteins for ARHGAP1 Gene

  • Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07960-RHG01_HUMAN
    Recommended name:
    Rho GTPase-activating protein 1
    Protein Accession:
    Q07960
    Secondary Accessions:
    • D3DQQ6

    Protein attributes for ARHGAP1 Gene

    Size:
    439 amino acids
    Molecular mass:
    50436 Da
    Quaternary structure:
    • Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
    SequenceCaution:
    • Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP1 Gene

neXtProt entry for ARHGAP1 Gene

Proteomics data for ARHGAP1 Gene at MOPED

Post-translational modifications for ARHGAP1 Gene

  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARHGAP1 Gene

Domains & Families for ARHGAP1 Gene

Gene Families for ARHGAP1 Gene

Suggested Antigen Peptide Sequences for ARHGAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07960

UniProtKB/Swiss-Prot:

RHG01_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP1: view

Function for ARHGAP1 Gene

Molecular function for ARHGAP1 Gene

GENATLAS Biochemistry:
Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Ontology (GO) - Molecular Function for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8253717
GO:0005096 GTPase activator activity IDA 8253717
GO:0005515 protein binding IPI 9262406
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ARHGAP1: view
genes like me logo Genes that share phenotypes with ARHGAP1: view

Animal Models for ARHGAP1 Gene

MGI Knock Outs for ARHGAP1:

Animal Model Products

CRISPR Products

miRNA for ARHGAP1 Gene

miRTarBase miRNAs that target ARHGAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene

Localization for ARHGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP1 Gene COMPARTMENTS Subcellular localization image for ARHGAP1 gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 2
plasma membrane 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0031252 cell leading edge --
genes like me logo Genes that share ontologies with ARHGAP1: view

Pathways & Interactions for ARHGAP1 Gene

genes like me logo Genes that share pathways with ARHGAP1: view

Gene Ontology (GO) - Biological Process for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 8253717
GO:0009967 positive regulation of signal transduction TAS 8253717
GO:0043087 regulation of GTPase activity --
genes like me logo Genes that share ontologies with ARHGAP1: view

No data available for SIGNOR curated interactions for ARHGAP1 Gene

Drugs & Compounds for ARHGAP1 Gene

(4) Drugs for ARHGAP1 Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HJC 0350 Pharma 0
arginine Nutra 346
Magnesium Nutra 0
tyrosine Nutra 547

(3) Additional Compounds for ARHGAP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fluoride
  • Fluoride
  • Fluoride ion
  • Fluorine anion
7782-41-4
gdp
gtp
Partial agonist, Agonist
genes like me logo Genes that share compounds with ARHGAP1: view

Transcripts for ARHGAP1 Gene

Unigene Clusters for ARHGAP1 Gene

Rho GTPase activating protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - -
SP9:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP1 Gene

GeneLoc Exon Structure for
ARHGAP1
ECgene alternative splicing isoforms for
ARHGAP1

Expression for ARHGAP1 Gene

mRNA expression in normal human tissues for ARHGAP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP1 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene Hs.138860

mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene

Q07960-RHG01_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with ARHGAP1: view

Protein tissue co-expression partners for ARHGAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARHGAP1 Gene

Orthologs for ARHGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP1 35
  • 89.9 (n)
  • 95.44 (a)
ARHGAP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP1 35
  • 91.19 (n)
  • 96.36 (a)
ARHGAP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap1 35
  • 89.37 (n)
  • 96.58 (a)
Arhgap1 16
Arhgap1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP1 35
  • 99.7 (n)
  • 99.54 (a)
ARHGAP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap1 35
  • 87.7 (n)
  • 94.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP1 35
  • 76.46 (n)
  • 82.28 (a)
lizard
(Anolis carolinensis)
Reptilia ARHGAP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap1 35
  • 73.84 (n)
  • 74.77 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap1 35
  • 63.78 (n)
  • 62.53 (a)
arhgap1 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 37
  • 37 (a)
RhoGAP68F 35
  • 54.31 (n)
  • 41.09 (a)
RhoGAP68F 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02B12.8 37
  • 39 (a)
rga-1 35
  • 50.32 (n)
  • 41.23 (a)
rga-1 36
  • 36 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1565.02c 35
  • 40.04 (n)
  • 28.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ARHGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP1 Gene

ENSEMBL:
Gene Tree for ARHGAP1 (if available)
TreeFam:
Gene Tree for ARHGAP1 (if available)

Paralogs for ARHGAP1 Gene

Paralogs for ARHGAP1 Gene

(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP1: view

Variants for ARHGAP1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs375122405 -- 46,679,001(+) CCGGG(A/C)TACCA utr-variant-3-prime
rs375088090 -- 46,680,614(+) CCGCC(A/G)TGGCC intron-variant
rs375055856 -- 46,695,623(+) AGGAG(C/T)TCTGA intron-variant
rs375008964 -- 46,679,475(+) TATGA(C/G)GAAAG intron-variant
rs374655580 -- 46,693,117(+) AAAAT(C/G)CTGGG intron-variant

Variation tolerance for ARHGAP1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGAP1 Gene

HapMap Linkage Disequilibrium report
ARHGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGAP1 Gene

Disorders for ARHGAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARHGAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
auditory agnosia
noma
  • cancrum oris
- elite association

Relevant External Links for ARHGAP1

Genetic Association Database (GAD)
ARHGAP1
Human Genome Epidemiology (HuGE) Navigator
ARHGAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP1
genes like me logo Genes that share disorders with ARHGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene

Publications for ARHGAP1 Gene

  1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PMID: 8288572) Lancaster C.A. … Hall A. (J. Biol. Chem. 1994) 2 23 67
  2. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. (PMID: 20179103) Pan C.Q. … Low B.C. (J. Cell. Sci. 2010) 23 67
  3. p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. (PMID: 19022332) Pamonsinlapatham P. … Raynaud F. (Biochimie 2009) 23 67
  4. DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. (PMID: 19066281) Scholz R.P. … Olayioye M.A. (J. Cell. Sci. 2009) 23 67
  5. Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. (PMID: 19103606) Mori K. … Kaibuchi K. (J. Biol. Chem. 2009) 23 67

Products for ARHGAP1 Gene

Sources for ARHGAP1 Gene

Back to Top

Content