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Aliases for ARHGAP1 Gene

Aliases for ARHGAP1 Gene

  • Rho GTPase Activating Protein 1 2 3
  • CDC42GAP 3 4 6
  • RHOGAP1 3 4 6
  • Rho-Related Small GTPase Protein Activator 3 4
  • Rho-Type GTPase-Activating Protein 1 3 4
  • GTPase-Activating Protein RhoOGAP 3 4
  • Cdc42 GTPase-Activating Protein 3 4
  • GTPase-Activating Protein, Rho, 1 3
  • GTPase-Activating Protein RhoGAP 3
  • Rho GTPase-Activating Protein 1 3
  • P50-RhoGAP 4
  • P50rhoGAP 3
  • RHOGAP 3

External Ids for ARHGAP1 Gene

Previous GeneCards Identifiers for ARHGAP1 Gene

  • GC11M048679
  • GC11M047576
  • GC11M046730
  • GC11M046662
  • GC11M046655
  • GC11M046404
  • GC11M046698

Summaries for ARHGAP1 Gene

Entrez Gene Summary for ARHGAP1 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

GeneCards Summary for ARHGAP1 Gene

ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include noma. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is PRR5-ARHGAP8.

UniProtKB/Swiss-Prot for ARHGAP1 Gene

  • GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Wiki entry for ARHGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP1 Gene

Genomics for ARHGAP1 Gene

Regulatory Elements for ARHGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP1 Gene

46,677,075 bp from pter
46,700,665 bp from pter
23,591 bases
Minus strand

Genomic View for ARHGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP1 Gene

Proteins for ARHGAP1 Gene

  • Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DQQ6

    Protein attributes for ARHGAP1 Gene

    439 amino acids
    Molecular mass:
    50436 Da
    Quaternary structure:
    • Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
    • Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP1 Gene

neXtProt entry for ARHGAP1 Gene

Proteomics data for ARHGAP1 Gene at MOPED

Post-translational modifications for ARHGAP1 Gene

  • Ubiquitination at Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARHGAP1 Gene

Domains for ARHGAP1 Gene

Gene Families for ARHGAP1 Gene

Suggested Antigen Peptide Sequences for ARHGAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP1: view

Function for ARHGAP1 Gene

Molecular function for ARHGAP1 Gene

GENATLAS Biochemistry:
Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate

Gene Ontology (GO) - Molecular Function for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8253717
GO:0005096 GTPase activator activity IDA 8253717
GO:0005515 protein binding IPI 11927263
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ARHGAP1: view
genes like me logo Genes that share phenotypes with ARHGAP1: view

Animal Models for ARHGAP1 Gene

MGI Knock Outs for ARHGAP1:

Animal Model Products

CRISPR Products

miRNA for ARHGAP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene

Localization for ARHGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene


Subcellular locations from

Jensen Localization Image for ARHGAP1 Gene COMPARTMENTS Subcellular localization image for ARHGAP1 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
golgi apparatus 2
nucleus 2
plasma membrane 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP1: view

Pathways for ARHGAP1 Gene

genes like me logo Genes that share pathways with ARHGAP1: view

Gene Ontology (GO) - Biological Process for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 8253717
GO:0009967 positive regulation of signal transduction TAS 8253717
GO:0043087 regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with ARHGAP1: view

Drugs for ARHGAP1 Gene

(1) ApexBio Compounds for ARHGAP1 Gene

Compound Action Cas Number
HJC 0350 [885434-70-8]

(6) Novoseek inferred chemical compound relationships for ARHGAP1 Gene

Compound -log(P) Hits PubMed IDs
gtp 67.5 9
gdp 56.6 5
arginine 30.1 6
fluoride 10.6 4
tyrosine 9.85 3
genes like me logo Genes that share compounds with ARHGAP1: view

Transcripts for ARHGAP1 Gene

Unigene Clusters for ARHGAP1 Gene

Rho GTPase activating protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - -

ExUns: 14b

Relevant External Links for ARHGAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP1 Gene

mRNA expression in normal human tissues for ARHGAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP1 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene Hs.138860

mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ARHGAP1: view

Expression partners for ARHGAP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARHGAP1 Gene

Orthologs for ARHGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP1 35
  • 89.9 (n)
  • 95.44 (a)
  • 95 (a)
(Canis familiaris)
Mammalia ARHGAP1 35
  • 91.19 (n)
  • 96.36 (a)
  • 96 (a)
(Mus musculus)
Mammalia Arhgap1 35
  • 89.37 (n)
  • 96.58 (a)
Arhgap1 16
Arhgap1 36
  • 89 (a)
(Pan troglodytes)
Mammalia ARHGAP1 35
  • 99.7 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arhgap1 35
  • 87.7 (n)
  • 94.53 (a)
(Monodelphis domestica)
Mammalia ARHGAP1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP1 36
  • 71 (a)
(Gallus gallus)
Aves ARHGAP1 35
  • 76.46 (n)
  • 82.28 (a)
(Anolis carolinensis)
Reptilia ARHGAP1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap1 35
  • 73.84 (n)
  • 74.77 (a)
(Danio rerio)
Actinopterygii arhgap1 35
  • 63.78 (n)
  • 62.53 (a)
arhgap1 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 37
  • 37 (a)
RhoGAP68F 35
  • 54.31 (n)
  • 41.09 (a)
RhoGAP68F 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea W02B12.8 37
  • 39 (a)
rga-1 35
  • 50.32 (n)
  • 41.23 (a)
rga-1 36
  • 36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1565.02c 35
  • 40.04 (n)
  • 28.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for ARHGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP1 Gene

Gene Tree for ARHGAP1 (if available)
Gene Tree for ARHGAP1 (if available)

Paralogs for ARHGAP1 Gene

Paralogs for ARHGAP1 Gene

(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP1: view

Variants for ARHGAP1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8914 -- 46,677,574(-) CTCTT(C/T)CTGCA utr-variant-3-prime
rs3923267 -- 46,694,845(-) GGGGG(G/T)GCTGG intron-variant
rs4319473 -- 46,681,141(+) TGTGG(A/G)GGCCC intron-variant
rs4400757 -- 46,698,249(-) TATTT(C/T)TGGGA intron-variant
rs4472899 -- 46,687,052(+) CACCC(A/C)CATCC intron-variant

Relevant External Links for ARHGAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGAP1 Gene

Disorders for ARHGAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ARHGAP1 Gene in MalaCards »

(1) Disease for ARHGAP1 Gene

(2) University of Copenhagen DISEASES for ARHGAP1 Gene

(4) Novoseek inferred disease relationships for ARHGAP1 Gene

Disease -log(P) Hits PubMed IDs
mental retardation 39.3 5
hepatocellular carcinoma 19.5 1
tumors 0 9
cancer 0 2

Relevant External Links for ARHGAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGAP1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene

Publications for ARHGAP1 Gene

  1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PMID: 8288572) Lancaster C.A. … Hall A. (J. Biol. Chem. 1994) 2 3 4 23
  2. The structure of the GTPase-activating domain from p50rhoGAP. (PMID: 9009196) Barrett T. … Eccleston J.F. (Nature 1997) 3 4 23
  3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis. (PMID: 12501193) Fidyk N.J. … Cerione R.A. (Biochemistry 2002) 3 23
  5. Exportin 7 defines a novel general nuclear export pathway. (PMID: 15282546) Mingot J.-M. … Goerlich D. (EMBO J. 2004) 3 4

Products for ARHGAP1 Gene

Sources for ARHGAP1 Gene

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