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Aliases for ARHGAP1 Gene

Aliases for ARHGAP1 Gene

  • Rho GTPase Activating Protein 1 2 3 5
  • Rho-Related Small GTPase Protein Activator 3 4
  • Rho-Type GTPase-Activating Protein 1 3 4
  • GTPase-Activating Protein RhoGAP 3 4
  • CDC42 GTPase-Activating Protein 3 4
  • CDC42GAP 3 4
  • RHOGAP1 3 4
  • GTPase-Activating Protein RhoOGAP 3
  • GTPase-Activating Protein, Rho, 1 3
  • P50-RhoGAP 4
  • P50rhoGAP 3
  • RHOGAP 3

External Ids for ARHGAP1 Gene

Previous GeneCards Identifiers for ARHGAP1 Gene

  • GC11M048679
  • GC11M047576
  • GC11M046730
  • GC11M046662
  • GC11M046655
  • GC11M046404
  • GC11M046698
  • GC11M047080
  • GC11M047925

Summaries for ARHGAP1 Gene

Entrez Gene Summary for ARHGAP1 Gene

  • This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

GeneCards Summary for ARHGAP1 Gene

ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include Noma and Auditory Agnosia. Among its related pathways are Signaling by Rho GTPases and Regulation of RAC1 activity. GO annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP1 Gene

  • GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Gene Wiki entry for ARHGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP1 Gene

Genomics for ARHGAP1 Gene

Regulatory Elements for ARHGAP1 Gene

Enhancers for ARHGAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGAP1 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGAP1 Gene

Chromosome:
11
Start:
46,677,075 bp from pter
End:
46,700,665 bp from pter
Size:
23,591 bases
Orientation:
Minus strand

Genomic View for ARHGAP1 Gene

Genes around ARHGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP1 Gene

Proteins for ARHGAP1 Gene

  • Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07960-RHG01_HUMAN
    Recommended name:
    Rho GTPase-activating protein 1
    Protein Accession:
    Q07960
    Secondary Accessions:
    • D3DQQ6

    Protein attributes for ARHGAP1 Gene

    Size:
    439 amino acids
    Molecular mass:
    50436 Da
    Quaternary structure:
    • Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
    SequenceCaution:
    • Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP1 Gene

neXtProt entry for ARHGAP1 Gene

Proteomics data for ARHGAP1 Gene at MOPED

Post-translational modifications for ARHGAP1 Gene

  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARHGAP1 Gene

Domains & Families for ARHGAP1 Gene

Gene Families for ARHGAP1 Gene

Suggested Antigen Peptide Sequences for ARHGAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07960

UniProtKB/Swiss-Prot:

RHG01_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with ARHGAP1: view

Function for ARHGAP1 Gene

Molecular function for ARHGAP1 Gene

GENATLAS Biochemistry:
Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Gene Ontology (GO) - Molecular Function for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,TAS --
genes like me logo Genes that share ontologies with ARHGAP1: view
genes like me logo Genes that share phenotypes with ARHGAP1: view

Animal Models for ARHGAP1 Gene

MGI Knock Outs for ARHGAP1:

Animal Model Products

CRISPR Products

miRNA for ARHGAP1 Gene

miRTarBase miRNAs that target ARHGAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene

Localization for ARHGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGAP1 Gene COMPARTMENTS Subcellular localization image for ARHGAP1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP1: view

Pathways & Interactions for ARHGAP1 Gene

genes like me logo Genes that share pathways with ARHGAP1: view

Pathways by source for ARHGAP1 Gene

Gene Ontology (GO) - Biological Process for ARHGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP1: view

No data available for SIGNOR curated interactions for ARHGAP1 Gene

Drugs & Compounds for ARHGAP1 Gene

(4) Drugs for ARHGAP1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HJC 0350 Pharma 0

(3) Additional Compounds for ARHGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ARHGAP1 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARHGAP1: view

Transcripts for ARHGAP1 Gene

Unigene Clusters for ARHGAP1 Gene

Rho GTPase activating protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - -
SP9:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARHGAP1 Gene

GeneLoc Exon Structure for
ARHGAP1
ECgene alternative splicing isoforms for
ARHGAP1

Expression for ARHGAP1 Gene

mRNA expression in normal human tissues for ARHGAP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP1 Gene



SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene Hs.138860

mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene

Q07960-RHG01_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ARHGAP1: view

Protein tissue co-expression partners for ARHGAP1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARHGAP1 Gene

Orthologs for ARHGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGAP1 35
  • 89.9 (n)
  • 95.44 (a)
ARHGAP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP1 35
  • 91.19 (n)
  • 96.36 (a)
ARHGAP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap1 35
  • 89.37 (n)
  • 96.58 (a)
Arhgap1 16
Arhgap1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP1 35
  • 99.7 (n)
  • 99.54 (a)
ARHGAP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgap1 35
  • 87.7 (n)
  • 94.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP1 35
  • 76.46 (n)
  • 82.28 (a)
lizard
(Anolis carolinensis)
Reptilia ARHGAP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap1 35
  • 73.84 (n)
  • 74.77 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap1 35
  • 63.78 (n)
  • 62.53 (a)
arhgap1 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 37
  • 37 (a)
RhoGAP68F 35
  • 54.31 (n)
  • 41.09 (a)
RhoGAP68F 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02B12.8 37
  • 39 (a)
rga-1 35
  • 50.32 (n)
  • 41.23 (a)
rga-1 36
  • 36 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1565.02c 35
  • 40.04 (n)
  • 28.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ARHGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP1 Gene

ENSEMBL:
Gene Tree for ARHGAP1 (if available)
TreeFam:
Gene Tree for ARHGAP1 (if available)

Paralogs for ARHGAP1 Gene

(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP1: view

Variants for ARHGAP1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11822837 - 46,679,391(+) GAAAC(A/G)AAGCA reference, missense
rs11602528 -- 46,678,761(+) GCTCA(A/G)TCCTT utr-variant-3-prime
rs7130157 -- 46,689,753(+) ccaag(A/C)tggtc intron-variant
rs61599937 -- 46,688,851(+) GCTGA(A/G)CCAGG intron-variant
rs61705152 -- 46,688,852(+) CTGAA(C/G)CAGGG intron-variant

Variation tolerance for ARHGAP1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ARHGAP1 Gene

Disorders for ARHGAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARHGAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
noma
  • cancrum oris
auditory agnosia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGAP1

Genetic Association Database (GAD)
ARHGAP1
Human Genome Epidemiology (HuGE) Navigator
ARHGAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGAP1
genes like me logo Genes that share disorders with ARHGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene

Publications for ARHGAP1 Gene

  1. Characterization of rhoGAP. A GTPase-activating protein for rho- related small GTPases. (PMID: 8288572) Lancaster C.A. … Hall A. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. (PMID: 19066281) Scholz R.P. … Olayioye M.A. (J. Cell. Sci. 2009) 3 23
  3. Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. (PMID: 19103606) Mori K. … Kaibuchi K. (J. Biol. Chem. 2009) 3 23
  4. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 23
  5. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. (PMID: 12944407) Shang X. … Low B.C. (J. Biol. Chem. 2003) 3 23

Products for ARHGAP1 Gene

Sources for ARHGAP1 Gene

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