Aliases for ARHGAP1 Gene
External Ids for ARHGAP1 Gene
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
GeneCards Summary for ARHGAP1 Gene
ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include noma. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is PRR5-ARHGAP8.
UniProtKB/Swiss-Prot for ARHGAP1 Gene
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate