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RHOC Gene

protein-coding GIFtS: 62

GC01M112955

ras homolog gene family, member C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ARH9, ARHC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARH9 ^², ³
ARHC ^², ³
H9 ^², ³
MGC1448 ^²
MGC61427 ^²
OTTHUMP00000013675 ^²
OTTHUMP00000013676 ^²
OTTHUMP00000013802 ^²
OTTHUMP00000013805 ^²
OTTHUMP00000013807 ^²
OTTHUMP00000013809 ^²
RHOH9 ^²
RhoC ^¹

Descriptions
RAS-related homolog 9 ^²
Rho-related GTP-binding protein RhoC ^²
oncogene RHO H9 ^²
ras homolog gene family, member C ^²
rhoC GTPase ^²
small GTP binding protein RhoC ^²

External Ids
HGNC: 669¹
Entrez Gene: 389²
UniProtKB: P08134³
Ensembl: ENSG00000155366⁷

Search outside databases for aliases for RHOC gene

Previous GC identifer: GC01M112544

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RHOC:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive

GDP-bound and active GTP-bound states and function as molecular switches in signal transduction

cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape,

attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and

localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion.

Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple

alternatively spliced variants, encoding the same protein, have been identified. [provided by

RefSeq]

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly

of focal adhesions and actin stress fibers

Gene Wiki entry for RHOC (RhoC)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RHOC gene

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

RHOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M112955: (about GC identifiers)

Start:	113,045,251 bp from pter
End:	113,051,548 bp from pter
Size:	6,298 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134 (See protein sequence)

Recommended Name: Rho-related GTP-binding protein RhoC precursor

Size: 193 amino acids; 22006 Da

Subunit: Interacts with DIAPH1, ROCK1, ROCK2 and RTKN. Interacts with AKAP13

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

PDB structures from and Proteopedia :

1Z2C (3D)

2GCN (3D)

2GCO (3D)

Secondary accessions: Q6ICN3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001036143.1 NP_001036144.1 NP_786886.1

ENSEMBL proteins:

ENSP00000358650 ENSP00000358656 ENSP00000358647 ENSP00000345236 ENSP00000285735 ENSP00000358652

ENSP00000358651 ENSP00000358646

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rho, RHOC, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
	Human Recombinant Proteins from Abnova (RHOC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for RHOC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RHOC
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RHOC
	Antibodies from Abcam (Rho, RHOC, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RHOC)
	Novus Biologicals Antibodies for RHOC

Assays for RHOC:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of RHOC
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08134

ProtoNet protein and cluster: P08134

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_175744

Applied Biosystems Silencer® siRNAs for RHOC

Sigma-Aldrich siRNA for RHOC

Sigma-Aldrich shRNA for RHOC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001042678
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001042678
untagged cDNA clones in CMV expression vector (see all 3): NM_001042678

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001042679

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly

of focal adhesions and actin stress fibers

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhoc):

cellular

immune system

tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	8468062
GO:0004871	signal transducer activity	IMP	12761501
GO:0005515	protein binding	IPI	15670823 17353931
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOC (Your Favorite Gene powered by Ingenuity) (see all 11 )

Cardiac Hypertrophy Signaling
CXCR4 Signaling
HMGB1 Signaling
IL-8 Signaling
Semaphorin Signaling in Neurons

GeneDecks RHOC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RHOC

5/139 Interacting proteins for RHOC (P08134^{1, 2} ENSP00000358647³) via UniProtKB, MINT, and/or STRING (see all 139 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGDIA	P52565¹, ENSP00000269321³	EBI-747589, EBI-712693 STRING (score=.999)
CNKSR1	Q969H4¹^,², ENSP00000363371³	EBI-747589, EBI-741671 MINT-56517 EBI-747589, EBI-741671 MINT-56517 STRING (score=.845)
VHL	P40337¹	EBI-747589, EBI-301246
CNKSR1	Q969H4¹^,², ENSP00000363371³	EBI-747589, EBI-741671 MINT-56517 EBI-747589, EBI-741671 MINT-56517 STRING (score=.845)
CNKSR1	Q969H4¹^,², ENSP00000363371³	EBI-747589, EBI-741671 MINT-56517 EBI-747589, EBI-741671 MINT-56517 STRING (score=.845)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP	12761501
GO:0045665	negative regulation of neuron differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RHOC

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RHOC
1 Novoseek chemical compound relationship for RHOC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	32.95	4	18377644 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_175744

Sigma-Aldrich siRNA for RHOC

Sigma-Aldrich shRNA for RHOC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001042678 NM_001042679 NM_175744

REFSEQ mRNAs for RHOC gene (3 alternative transcripts):

NM_001042678.1 NM_001042679.1 NM_175744.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001042678 NM_001042679 NM_175744

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001042678
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001042678
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001042678

Additional cDNA sequence: AF085893.1

24/46 DOTS entries (see all 46 ):

DT.219329 DT.92471967 DT.99926463 DT.101986475 DT.95102696 DT.100673039 DT.121433304 DT.121433252

DT.95285439 DT.428367 DT.87079300 DT.100673034 DT.100673046 DT.121433186 DT.121433212 DT.100759962

DT.121433215 DT.121433298 DT.92471807 DT.86851430 DT.95091621 DT.95103840 DT.99926455 DT.100716118

24/712 AceView cDNA sequences (see all 712 ):

CR601446 BC064628 CB131033 BQ920836 BQ648340 CB108173 BM841965 BC073828

BM821555 AI955324 CB216543 BU628835 CA489413 BU737640 BU171367 BM460704

BQ685503 BU521068 CR614305 BI835582 AI685637 BM854662 BE407130 CR613350

highest scoring ESTs for RHOC:

AK094474 AL048554 AU099800 AW891279 BC007245 BC009177 BC052808 BE713147 BE713152 BE713171

Unigene Clusters for RHOC:

Ras homolog gene family, member C

Hs.502659 [show with all ESTs], Hs.658289 [show with all ESTs]

Unigene Representative Sequences: AK094474, BI000596

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RHOC (see all 11 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	·	11f	·	11g	·	11h
SP1:							-		-		-		-				-		-		-		-		-				-
SP2:							-		-		-						-		-		-		-		-				-
SP3:											-		-				-		-		-		-		-				-
SP4:													-				-		-		-		-		-				-
SP5:																	-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for RHOC

8 Ensembl transcripts including schematic representations:

ENST00000369636 ENST00000369642 ENST00000369633 ENST00000339083 ENST00000285735 ENST00000369638

ENST00000369637 ENST00000369632

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RHOC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RHOC

¹ / ² / ³

5 probe-sets matching RHOC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1395_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.80	L25081	0.80	1.00	0.91	1
89924_at²^{, 3}	U95-D	1	0.75	1.00	0.95	1.26	AI860379	0.60	1.00	0.82	1
74701_at²^{, 3}	U95-D	2	0.75	0.92	0.98	0.94	AW003897	0.60	1.00	0.82	1
200885_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_005167	0.20	0.33	0.27	2
200885_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGTCAACAG

SOURCE GeneReport for Unigene clusters: Hs.502659 Hs.658289
Expression variation in blood from EXPOLDB for RHOC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RHOC gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RHOC¹	--	ras homolog gene family, member C	93.09(n) 100(a)	483218 XM_540336.2 XP_540336.2
cow (Bos taurus)	RHOC¹	--	ras homolog gene family, member C	93.44(n) 100(a)	513152 NM_001046138.1 NP_001039603.1
rat (Rattus norvegicus)	Rhoc¹	--	ras homolog gene family, member C	92.4(n) 99.48(a)	295342 XM_215659.4 XP_215659.1
mouse (Mus musculus)	Rhoc^{1, 5}	3⁵	ras homolog gene family, member C^{1, 5}	91.88(n)¹ 99.48(a)¹	11853¹ NM_007484.1¹ NP_031510.1¹ AI324259⁵ AK011599⁵ (see all 12)
chicken (Gallus gallus)	RHOC¹	--	ras homolog gene family, member C	85.15(n) 96.89(a)	395869 NM_001029849.1 NP_001025020.1

About this table Species with no ortholog for RHOC

ENSEMBL Gene Tree for RHOC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RHOC gene

RHOB² RHOA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/62 NCBI SNPs in RHOC are shown (see all 62 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11102522^1,2	A,C,F,H	113052411(+)	`GACATT/CTGACA`	3	--	ng3¹		4		EU EA WA	412
--	rs11538959^1,2	C,F,H	113046758(-)	`AGAAGG/CACCTG`	3	H/D	mis¹ ese³		8		EU EA WA	812
	rs1059482^1,2	A,C	113045402(-)	`CACTTC/TTGGCT`	3	--	ut3¹ ese³		1		MN	184
	rs3125045^1,2	A,C	113051925(+)	`GCTTCC/TGGATC`	3	--	ng3¹		0	--	--	--	--
--	rs3806443^1,2	C	113051009(-)	`GGCCCC/GGACCT`	3	--	int¹ ut5¹ ese³		0	--	--	--	--
	rs1059479^1,2	F	113045415(-)	`CCAGCA/CCTTTA`	3	--	ut3¹		1		MN	184
	rs1059411^1,2	A	113045505(-)	`GCGCTC/TTGGGA`	3	--	ut3¹		1		MN	184
--	rs3806442^1,2	C	113051027(-)	`CCCGGA/GCTGCA`	3	--	ut5¹ int¹ ese³		0	--	--	--	--
	rs954679^1,2	A,C,F,H,O	113049888(+)	`TTTGTA/GAAGAT`	3	--	int¹ ese³		16		EA NA NS EU WA	1038
	rs12144044^1,2	A,C,F,H	113050314(+)	`TGTGGC/ATACAT`	3	--	int¹ ese³		12		EU EA WA	1258

About this table

HapMap Linkage Disequilibrium images for RHOC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165380

10/16 Novoseek disease relationships for RHOC gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammatory breast cancer	84.29	2	16187229 (1), 12479217 (1)
metastasis	56.34	63	18980974 (7), 18794150 (4), 17549441 (4), 16899593 (3) (see all 21)
breast cancer	42.01	19	16187229 (5), 18478927 (5), 12939257 (1), 7713753 (1) (see all 8)
tumors	39.90	68	18794150 (6), 12855641 (5), 12970882 (3), 11839578 (3) (see all 14)
breast diseases	36.49	1	11839578 (1)
cancer	35.86	8	15604264 (1), 12479217 (1), 17549441 (1), 16470169 (1) (see all 6)
primary tumor	31.46	6	16899593 (2), 15312362 (2), 12808121 (1), 15867248 (1)
breast carcinoma	28.83	4	11839578 (2), 15574779 (2)
hepatocellular carcinoma	24.89	9	12970882 (2), 15312362 (2), 17265125 (2), 15150600 (1) (see all 5)
carcinoma	23.02	12	11839578 (3), 16187229 (2), 16899593 (2), 12808121 (2) (see all 5)

About this table

Human Genome Epidemiology Navigator: RHOC (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/103 PubMed articles for RHOC gene (see all 103 ):

Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)^{2, 3, 4} Chardin P.... Tavitian A. (1988)
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PubMed id 8816443)^{1, 3, 4} Leung T.... Lim L. (1996)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. (PubMed id 15864301)^{3, 4} Rose R....Wittinghofer A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. (PubMed id 11546812)^{3, 4} Diviani D.... Scott J.D. (2001)
RhoC is essential for the metastasis of gastric cancer. (PubMed id 17549441)^{1, 3} Liu N....Fan D. (2007)
Inhibition of invasion and metastasis of hepatocellular carcinoma cells via targeting RhoC in vitro and in vivo. (PubMed id 18980974)^{1, 3} Wang W....Yang L. (2008)
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. (PubMed id 18794150)^{1, 3} Iiizumi M....Watabe K. (2008)
Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma. (PubMed id 17896152)^{1, 3} Faried A....Kuwano H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 389	HGNC: 669	AceView: RHOCandPPP2CZ	Ensembl:ENSG00000155366	euGenes: HUgn389
ECgene: RHOC	H-InvDB: RHOC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RHOC	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RHOC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RHOC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RHOC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RHOC		Antibodies for RHOC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RHOC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RHOC)
	Antibodies (RHOC)
	Chimera RNAi (RHOC)
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Antibodies & Assays for RHOC

	Recombinant Proteins (Rho, RHOC, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
	Antibodies (Rho, RHOC, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)

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	Drugs for RHOC
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RHOC

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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RHOC Gene at Home site.
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RHOC Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for RHOC

Summaries
for RHOC

Genomic Location
for RHOC

Proteins
for RHOC

Protein Domains/
Families
for RHOC

Gene Function
for RHOC

Pathways & Interactions
for RHOC

Drugs & Compounds
for RHOC

Transcripts
for RHOC

Expression
for RHOC

Orthologs
for RHOC

Paralogs
for RHOC

SNPs/Variants
for RHOC

Disorders & Mutations
for RHOC

Medical News
for RHOC

Publications
for RHOC

Search for RHOC

Genome Databases showing RHOC

Other Databases showing RHOC

Specialized Databases showing RHOC

Licensable Technologies
for RHOC

Services
for RHOC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RHOC (Gene Symbol)
ARH9
ARHC
H9
MGC1448
MGC61427
OTTHUMP00000013675
OTTHUMP00000013676
OTTHUMP00000013802
OTTHUMP00000013805
OTTHUMP00000013807
OTTHUMP00000013809
RHOH9
RhoC
RAS-related homolog 9
Rho-related GTP-binding protein RhoC
oncogene RHO H9
ras homolog gene family, member C
rhoC GTPase
small GTP binding protein RhoC

RHOC Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor RHOC

Summariesfor RHOC

Genomic Locationfor RHOC

Proteinsfor RHOC

Protein Domains/Familiesfor RHOC

Gene Functionfor RHOC

Pathways & Interactionsfor RHOC

Drugs & Compoundsfor RHOC

Transcriptsfor RHOC

Expression for RHOC

Orthologsfor RHOC

Paralogsfor RHOC

SNPs/Variantsfor RHOC

Disorders & Mutationsfor RHOC

Medical Newsfor RHOC

Publicationsfor RHOC

Search for RHOC

Genome Databases showing RHOC

Other Databases showing RHOC

Specialized Databases showing RHOC

Licensable Technologiesfor RHOC

Servicesfor RHOC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RHOC

Summaries
for RHOC

Genomic Location
for RHOC

Proteins
for RHOC

Protein Domains/
Families
for RHOC

Gene Function
for RHOC

Pathways & Interactions
for RHOC

Drugs & Compounds
for RHOC

Transcripts
for RHOC

Expression
for RHOC

Orthologs
for RHOC

Paralogs
for RHOC

SNPs/Variants
for RHOC

Disorders & Mutations
for RHOC

Medical News
for RHOC

Publications
for RHOC

Licensable Technologies
for RHOC

Services
for RHOC