V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

RHOB Gene

protein-coding   GIFtS: 59

GC02P020510
ras homolog gene family, member B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ARH6, ARHB)
Services    

Aliases &
Descriptions
for RHOB

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ARH6 2, 3
ARHB 2, 3
H6 3
MST081 1, 2
MSTP081 2
RHOH6 1, 2
RhoB 1
Descriptions
Aplysia RAS-related homolog 6 2
oncogene RHO H6 2
ras homolog gene family, member B 2
External Ids
HGNC: 6681
Entrez Gene: 3882
UniProtKB: P627453
Ensembl: ENSG000001438787
Search outside databases for aliases for RHOB gene

Previous GC identifers: GC02P020632 GC02P020568

Summaries
for RHOB

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential
for development but affects cell adhesion and growth factor signaling in transformed cells. Plays
a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular
protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in
trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and
nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular
development

Gene Wiki entry for RHOB

Genomic Location
for RHOB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RHOB gene  

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24

RHOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P020510:     (about GC identifiers)

Start:
 20,510,316 bp from pter
End:
 20,512,682 bp from pter
Size:
 2,367 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000002.10  NT_015926.14  

Proteins
for RHOB

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoB precursor  
Size: 196 amino acids; 22123 Da
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13
Subcellular location: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus.
Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also
detected at the nuclear margin and in the nucleus
Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors which are currently
under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB
and cause mislocalization, leading to apoptosis and antineoplastic effects
PDB structures from and Proteopedia :
2FV8 (3D)    
Secondary accessions: P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Post-translational modifications:

  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the
    plasma membrane while the geranylgeranylated form is localized to the endosome1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_004031.1  

    ENSEMBL proteins: 
    ENSP00000384023 ENSP00000272233 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RHOB, Rho, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
    Human Recombinant Proteins from Abnova (RHOB)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005624 membrane fraction IEA--
    GO:0005625 soluble fraction IEA--
    GO:0005634 nucleus ISS--
    GO:0005768 endosome IEA--
    About this table

    Antibodies for RHOB: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RHOB
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RHOB 
    Antibodies from Abcam (RHOB, Rho, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RHOB)
    Search Novus for antibodies for RHOB

    Assays for RHOB: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of RHOB
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for RHOB

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR013753 Ras
     IPR003578 GTPase_Rho
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd


       GeneDecks  RHOB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P62745

    ProtoNet protein and cluster: P62745

    UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Similarity: Belongs to the small GTPase superfamily. Rho family

    Gene Function
    for RHOB

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RHOB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004040

                  Applied Biosystems Silencer® siRNAs for RHOB

                  Sigma-Aldrich siRNA and siRNA Panels for RHOB  
                         Sigma-Aldrich shRNA Panels and shRNA for RHOB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RHOB
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004040
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004040
                                     untagged cDNA clone in CMV expression vector: NM_004040 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004040

    UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential
    for development but affects cell adhesion and growth factor signaling in transformed cells. Plays
    a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular
    protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in
    trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and
    nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular
    development

    6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhob):

    cellulargrowth/sizehomeostasis/metabolismtumorigenesis
    vision/eye

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS3888408
    GO:0005515 protein binding IEA--
    GO:0005525 GTP binding TAS1400319
    GO:0019003 GDP binding IEA--
    About this table

    Pathways & Interactions
    for RHOB

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for RHOB
     G-protein signaling RhoB regulation pathway

       GeneDecks  RHOB for the pathways selected above  
    About GeneDecksing

    5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for  RHOB  (Your Favorite Gene powered by Ingenuity) (see all 11 ) 
     Germ Cell-Sertoli Cell Junction Signaling
     Cholecystokinin/Gastrin-mediated Signaling
     Semaphorin Signaling in Neurons
     Cardiac Hypertrophy Signaling
     HMGB1 Signaling

       GeneDecks  RHOB for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  RHOB 


    5/149 Interacting proteins for RHOB (ENSP000002722333 P627452) via UniProtKB, MINT, and/or STRING (see all 149 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062132MINT-6800491
    PTPN1P180312MINT-6800506
    ARHGEF3ENSP000003410713STRING (score=.992)
    ARHGDIGENSP000003724203STRING (score=.98)
    MCF2ENSP000003596103STRING (score=.98)
    About this table

    5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006927 transformed cell apoptosis ISS--
    GO:0007155 cell adhesion ISS--
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0007266 Rho protein signal transduction TAS3888408
    GO:0007275 multicellular organismal development IEA--
    About this table

    Drugs & Compounds
    for RHOB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RHOB
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RHOB
    8 Novoseek chemical compound relationships for RHOB gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    geranylgeranyl pyrophosphate 48.48 6 12427032 (2), 12384510 (1)
    mevalonate 47.12 7 11788600 (2), 12384510 (2), 12427032 (2)
    gdp 37.03 6 8939998 (3)
    gtp 34.94 15 8939998 (3), 18377644 (3), 17198702 (1), 11918088 (1)
    methionine 9.49 1 16170025 (1)
    threonine 8.06 2 9478917 (1), 18590726 (1)
    cholesterol 0.00 3 18388257 (1), 12384510 (1), 11162504 (1)
    glycogen 0.00 2 16247449 (1), 16278215 (1)
    About this table


    Transcripts
    for RHOB

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RHOB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004040

                  Sigma-Aldrich siRNA and siRNA Panels for RHOB  
                         Sigma-Aldrich shRNA Panels and shRNA for RHOB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004040  

    REFSEQ mRNAs for RHOB gene: 

    NM_004040.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004040  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004040
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004040
                                     untagged cDNA clone in CMV expression vector: NM_004040 

    Additional cDNA sequence: 

    AF171089.1 AF498971.1 AK124398.1 AK297495.1 AK309991.1 AK310813.1 AK312487.1 BC062781.1 
    BC066954.1 BT019546.1 BT019547.1 CR542272.1 CR626079.1 M12174.1 X06820.1 

    20 DOTS entries:

    DT.92339462  DT.92033160  DT.92327084  DT.120991656  DT.120991663  DT.91778836  DT.100798162  DT.95377224 
    DT.220260  DT.91778826  DT.100798160  DT.91778839  DT.100798158  DT.87018075  DT.91778835  DT.91852109 
    DT.95376747  DT.95377285  DT.100798169  DT.40115663 

    24/864 AceView cDNA sequences (see all 864 ):

    AI632215 BE463681 AW103688 H88963 BF732567 AI433662 AI076237 AI871029 
    AI189876 AW169428 BM921603 AI220416 AW052113 CR542272 AI521893 BQ025501 
    CD677191 BU950449 AI082782 AI964043 AI417030 AI480356 BF063088 BF196534 

    highest scoring ESTs for RHOB:

    M12174 AA024540 AA035127 AA056220 AA056221 AA128528 AA129963 AA176140 AA176239 AA187776 

    Unigene Cluster for RHOB:

    Ras homolog gene family, member B
    Hs.502876  [show with all ESTs]
    Unigene Representative Sequence: NM_004040


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000405629  ENST00000272233  

    Expression
    for RHOB

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RHOB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RHOB

    1 / 2 / 3

    6 probe-sets matching RHOB gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1826_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M12174 1.00 1.00 1.00 1

    		212099_at2, 3 U133-A 1 1.00 1.00 -- -- AI263909 0.80 1.00 0.91 1

    		212099_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1553962_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1553965_x_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --

    		1553963_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    GeneDecks  RHOB for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CACACAGTTT

    SOURCE GeneReport for Unigene cluster: Hs.502876

    Expression variation in blood from EXPOLDB for RHOB

    Orthologs
    for RHOB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RHOB gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 RHOB1   -- ras homolog gene family, member B 96.77(n)
    99.49(a)    		 403670  XM_540101.2  XP_540101.2 
    chimpanzee
    (Pan troglodytes)    		 RHOB1   -- ras homolog gene family, member B 99.49(n)
    100(a)    		 459054  XM_001141071.1  XP_001141071.1 
    cow
    (Bos taurus)    		 RHOB1   -- ras homolog gene family, member B 96.6(n)
    100(a)    		 515118  XM_001251998.1  XP_001251999.1 
    rat
    (Rattus norvegicus)    		 Rhob1   -- ras homolog gene family, member B 95.07(n)
    100(a)    		 64373  NM_022542.1  NP_071987.1 
    mouse
    (Mus musculus)    		 Rhob1, 5 125
    		 ras homolog gene family, member B1, 5 94.9(n)1
    100(a)1    		 118521  NM_007483.21  NP_031509.11 
     AA0178825  AF4819435  (see all 18)
    About this table        Species with no ortholog for RHOB

    ENSEMBL Gene Tree for RHOB

    Paralogs
    for RHOB

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RHOB gene
    RHOA2  RHOC2  

    SNPs/Variants
    for RHOB

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/58 NCBI SNPs in RHOB are shown (see all 58 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs75791251,2
    		C,F,H20512971(+) ATCTTG/AATTTC 1 -- ng317Minor allele frequency- A:0.06EU EA WA NA 560
    rs10622921,2
    		A,C,F20511692(+) TGTTCG/TCCCTT 1 -- ut31 ese31Minor allele frequency- T:0.41MN 184
    rs26021601,2
    		A,C20508987(-) TGCACA/GCCAGG 1 -- ng510--------
    rs30882961,2
    		A,H20512683(-) ATTTTA/TTAAAT 1 -- ng31 spl35Minor allele frequency- T:0.01MN EU EA WA 600
    --
    rs29243781,2
    		A,C20509147(-) TAGAAC/TGTACA 1 -- ng510--------
    --
    rs5850171,2
    		A,C20510113(+) AGCGCA/GGACTC 1 -- ng510--------
    rs10621921,2
    		F20511341(+) TCCCCC/TTCCTG 1 -- ut31 ese3 trp31Minor allele frequency- T:0.02MN 184
    --
    rs358813361,2
    		F20510113(+) GCGCAA/GGACTC 1 -- ng512Minor allele frequency- G:0.31EU 730
    rs70431,2
    		C,F20510722(+) ATCCGC/TAAGAA 1 R/R syn1 ese31Minor allele frequency- T:0.05MN 184
    --
    rs669532961,2
    		--20513012(+) CTTTA-/TAGTCT 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for RHOB (up to first 250kb)

    Disorders & Mutations
    for RHOB

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 165370

    10 Novoseek disease relationships for RHOB gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 29.83 26 15102679 (4), 18340357 (3), 11918088 (3), 18047684 (2) (see all 14)
    cancer 27.84 11 15102679 (2), 14647415 (2), 16909123 (2), 16247449 (1) (see all 6)
    neoplastic transformation 21.57 1 12706111 (1)
    cancer lung 19.87 19 15102679 (5), 18047684 (4), 11641777 (1), 17096327 (1) (see all 5)
    nsclc 18.31 13 17096327 (6)
    ovarian cancer 14.33 5 16796923 (3), 18340357 (2)
    metastasis 11.48 2 12939257 (1), 16909123 (1)
    adenocarcinoma 6.90 4 17096327 (2), 15102679 (1)
    necrosis 0.00 1 11062238 (1)
    carcinoma 0.00 1 15102679 (1)
    About this table

    Human Gene Mutation Database: RHOB
    Human Genome Epidemiology Navigator: RHOB (2 documents)

    Medical News
    for RHOB

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RHOB

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/147 PubMed articles for RHOB gene (see all 147 ):

    Search for RHOB

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RHOB

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 388 HGNC: 668 AceView: RHOB Ensembl:ENSG00000143878 euGenes: HUgn388
    ECgene: RHOB H-InvDB: RHOB

    Other Databases showing RHOB

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RHOB

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RHOB Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for RHOB

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RHOB

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RHOB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RHOB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RHOB Antibodies for RHOB
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RHOB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (RHOB)
     Antibodies (RHOB)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for RHOB 

     Recombinant Proteins
    (RHOB, Rho, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
     Antibodies (RHOB, Rho, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
     Search OriGene for RHOB
     Search Tocris compounds for RHOB




     Drugs for RHOB
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for RHOB

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    RHOB Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com