V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

RHOA Gene

protein-coding GIFtS: 60

GC03M049371

ras homolog gene family, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ARH12, ARHA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARH12 ^², ³
ARHA ^², ³
H12 ^³
RHO12 ^², ³
RHOH12 ^¹, ²
Rho12 ^¹
RhoA ^¹

Descriptions
Aplysia ras-related homolog 12 ^²
oncogene RHO H12 ^²
ras homolog gene family, member A ^²
small GTP binding protein RhoA ^²

External Ids
HGNC: 667¹
Entrez Gene: 387²
UniProtKB: P61586³
Ensembl: ENSG00000067560⁷

Search outside databases for aliases for RHOA gene

Previous GC identifer: GC03M049357

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly

of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase

from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes

gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the

exchange of GDP for GTP

Gene Wiki entry for RHOA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RHOA gene

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

RHOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M049371: (about GC identifiers)

Start:	49,371,582 bp from pter
End:	49,424,530 bp from pter
Size:	52,949 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 (See protein sequence)

Recommended Name: Transforming protein RhoA precursor

Size: 193 amino acids; 21768 Da

Cofactor: Magnesium

Subunit: Interacts with RGNEF (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with

ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with human respiratory

syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton

PDB structures from and Proteopedia :

1A2B (3D)

1CC0 (3D)

1CXZ (3D)

1DPF (3D)

1FTN (3D)

1KMQ (3D)

1LB1 (3D)

1OW3 (3D)

1S1C (3D)

1TX4 (3D)

1X86 (3D)

1XCG (3D)

2RGN (3D)

Secondary accessions: P06749 Q5U024 Q9UEJ4

Post-translational modifications:

Substrate for botulinum ADP-ribosyltransferase¹

Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the

lipid attachment, and leads to its displacement from plasma membrane and to subsequent

cytoskeleton cleavage¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001655.1

ENSEMBL proteins:

ENSP00000265538

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant RHOA Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rho, RhoA, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
	Human Recombinant Proteins from Abnova (RHOA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for RHOA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of RHOA
	Sigma-Aldrich Antibodies for RHOA
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RHOA
	Antibodies from Abcam (Rho, RhoA, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RHOA)
	Novus Biologicals Antibodies for RHOA

Assays for RHOA:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of RHOA
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61586

ProtoNet protein and cluster: P61586

1 Blocks protein family: IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Domain: The basic-rich region is essential for yopT recognition and cleavage

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001664

Applied Biosystems Silencer® siRNAs for RHOA

Sigma-Aldrich siRNA and siRNA Panels for RHOA

Sigma-Aldrich shRNA Panels and shRNA for RHOA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RHOA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001664
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001664
untagged cDNA clone in CMV expression vector: NM_001664

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001664

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly

of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase

from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes

gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the

exchange of GDP for GTP

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0003924	GTPase activity	TAS	10436159
GO:0005515	protein binding	IPI	15644318
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/19 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOA (Your Favorite Gene powered by Ingenuity) (see all 19 )

HMGB1 Signaling
Integrin Signaling
Cardiac Hypertrophy Signaling
Macropinocytosis
Actin Cytoskeleton Signaling

GeneDecks RHOA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RHOA

5/23 Interacting proteins for RHOA (P61586^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 23 )
Interactant Interaction Details
GeneCard External ID(s)
CNKSR1 Q969H4¹^,² EBI-446668, EBI-741671 MINT-56522 MINT-56518 MINT-56516 MINT-56519 EBI-446668, EBI-741671 MINT-56522 MINT-56518 MINT-56516 MINT-56519
RTKN Q9BST9¹^,² EBI-446668, EBI-446694 MINT-7146266 EBI-446668, EBI-446694 MINT-7146266
ARHGAP1 Q07960¹ EBI-446668, EBI-602762
ARHGDIA P52565¹ EBI-446668, EBI-712693
ARHGEF5 Q12774¹ EBI-446668, EBI-602199
About this table
5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 10436159
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RHOA
10/47 Novoseek chemical compound relationships for RHOA gene (see all 47 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mdi-a	84.76	21	12847276 (4), 12445462 (2), 17307336 (2), 18829452 (1) (see all 11)
geranylgeranyl pyrophosphate	84.69	23	11864926 (2), 16873994 (2), 17947676 (2), 11334884 (1) (see all 14)
gdp	71.79	36	11342655 (3), 11864926 (2), 9548756 (2), 9199174 (2) (see all 23)
geranylgeraniol	71.62	6	15951198 (2), 16740276 (1), 10559211 (1), 12771933 (1) (see all 5)
mevalonate	70.30	10	11788600 (2), 12427032 (2), 11286990 (1), 17075836 (1) (see all 7)
gtp	69.67	89	10716190 (4), 18377644 (3), 12620811 (3), 16914531 (3) (see all 44)
actomyosin	67.32	16	17646397 (2), 18086913 (2), 17446864 (1), 16721066 (1) (see all 12)
farnesyl diphosphate	65.36	8	11334884 (1), 11470741 (1), 16858009 (1), 17237547 (1) (see all 5)
1-oleoyl-lyso-phosphatidic acid	58.38	4	9478968 (1), 10213513 (1)
phosphatidylinositol	55.99	25	10843867 (3), 15339992 (3), 12860457 (1), 15169791 (1) (see all 17)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001664

Sigma-Aldrich siRNA and siRNA Panels for RHOA

Sigma-Aldrich shRNA Panels and shRNA for RHOA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001664

REFSEQ mRNAs for RHOA gene:

NM_001664.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001664

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001664
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001664
                                 untagged cDNA clone in CMV expression vector: NM_001664

Additional cDNA sequence:

AF498970.1 AK130066.1 AK130808.1 AK222556.1 AK296654.1 AK307220.1 BC000946.3 BC001360.2

BC005976.1 BT019870.1 BX647063.1 CR590795.1 CR591837.1 CR592238.1 CR594903.1 CR595507.1

CR595947.1 CR596439.1 CR596598.1 CR596885.1 CR598647.1 CR600849.1 CR601531.1 CR602199.1

CR602563.1 CR602766.1 CR602977.1 CR605973.1 CR607421.1 CR607713.1 CR608339.1 CR608641.1

CR610129.1 CR610290.1 CR613062.1 CR617634.1 CR620398.1 CR621617.1 CR623439.1 CR624260.1

CR624876.1 L09159.1 L25080.1 X05026.1

24/66 DOTS entries (see all 66 ):

DT.91860959 DT.100695868 DT.100695864 DT.100695869 DT.120904554 DT.97868367 DT.100695874 DT.453628

DT.91777469 DT.100695847 DT.100059757 DT.91777425 DT.91777473 DT.100695880 DT.100695892 DT.100695881

DT.91777456 DT.100849651 DT.120904717 DT.120904642 DT.100695902 DT.100853328 DT.100853666 DT.100695876

24/2393 AceView cDNA sequences (see all 2393 ):

BM787053 F09126 CB143490 AL517655 BG391392 AU157538 BP367807 N33344

BM799554 CR600849 AU132231 AW328532 CD722386 CF128377 AW575016 CK430592

BG777693 BQ897808 AW675705 BI871326 AA343555 BQ027088 BE646213 BU156652

highest scoring ESTs for RHOA:

L25080 AA182690 AA247174 AA295595 AA307327 AA314467 AA315468 AA315470 AA353360 AA353622

Unigene Cluster for RHOA:

Ras homolog gene family, member A

Hs.247077 [show with all ESTs]

Unigene Representative Sequence: NM_001664

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RHOA

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:
SP2:							-
SP3:					-		-		-
SP4:							-		-		-

About this scheme

ECgene alternative splicing isoforms for RHOA

1 Ensembl transcript including schematic representation:

ENST00000265538

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RHOA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RHOA

¹ / ² / ³

5 probe-sets matching RHOA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37309_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.08	L09159	0.80	1.00	0.91	1
1394_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.92	L25080	1.00	1.00	1.00	1
200059_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC001360	0.80	1.00	0.91	1
200059_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555814_a_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACTTGGGCT

SOURCE GeneReport for Unigene cluster: Hs.247077
Expression variation in blood from EXPOLDB for RHOA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RHOA gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RHOA¹	--	ras homolog gene family, member A	95.34(n) 100(a)	403954 XM_850493.1 XP_855586.1
chimpanzee (Pan troglodytes)	RHOA¹	--	ras homolog gene family, member A	100(n) 100(a)	461014 XM_001163811.1 XP_001163811.1
cow (Bos taurus)	RHOA¹	--	ras homolog gene family, member A	93.96(n) 100(a)	338049 NM_176645.3 NP_788818.1
rat (Rattus norvegicus)	Rhoa¹	--	ras homolog gene family, member A	94.13(n) 99.48(a)	117273 NM_057132.2 NP_476473.1
mouse (Mus musculus)	Rhoa^{1, 5}	9⁵	ras homolog gene family, member A^{1, 5}	93.78(n)¹ 99.48(a)¹	11848¹ NM_016802.3¹ NP_058082.2¹ AF014371⁵ AF178958⁵ (see all 21)

About this table Species with no ortholog for RHOA

ENSEMBL Gene Tree for RHOA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RHOA gene

RHOB² RHOC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/299 NCBI SNPs in RHOA are shown (see all 299 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs11552761^1,2	H	49387977(-)	`CTGTGG/AAAAGA`	1	E/G	mis¹ ese³		4	EU EA WA	406
--	rs11552762^1,2	H	49387931(-)	`CCAGAG/TGTGTA`	1	E/D	mis¹ ese³		4	EU EA WA	404
	rs974495^1,2	A,C,F,H,O	49375486(-)	`AAAGAG/ACATGT`	1	--	int¹ trp³		8	EU EA WA NA	625
--	rs9847585^1,2	A,C,F,H	49389066(+)	`cagagC/Taagac`	1	--	int¹		4	EU EA WA	392
--	rs4855842^1,2	A,C,F,H	49408137(-)	`agtctT/Cgctct`	1	--	int¹		3	EU EA	284
	rs1987628^1,2	A,C,F,H	49374263(-)	`tatctC/Tggctg`	1	--	int¹		4	EU EA WA	402
--	rs6809216^1,2	A,C,F,H	49387563(+)	`tggtgG/Acaaca`	1	--	int¹		4	EU EA WA	396
--	rs6792911^1,2	A,C,F,H	49404860(+)	`ggtgcT/Cagagt`	1	--	int¹		4	EU EA WA	406
--	rs11719762^1,2	A,C,F,H	49384006(+)	`gctacC/Gacgtc`	1	--	int¹		4	EU EA WA	402
	rs7621003^1,2	A,C,F,H	49386408(+)	`GCTTTC/TAGGAC`	1	--	int¹		12	EU EA WA NA	1048

About this table

HapMap Linkage Disequilibrium images for RHOA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165390

10/62 Novoseek disease relationships for RHOA gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	35.09	29	17597401 (2), 12581011 (2), 12939257 (1), 19264906 (1) (see all 17)
cancer	30.64	36	14598891 (3), 15059348 (2), 17273773 (2), 15604264 (1) (see all 26)
tumors	30.30	123	8302578 (6), 12855641 (5), 10328216 (4), 17881360 (3) (see all 50)
cardiac hypertrophy	22.35	2	15715922 (1), 17468766 (1)
atherosclerosis	19.33	1	12860900 (1)
carcinoma non-small cell lung	18.95	1	17684444 (1)
megakaryoblastic leukemia acute	16.28	2	8608802 (1), 15953360 (1)
prostate cancer	16.19	10	16402387 (3), 16231705 (2), 12649199 (1), 16316623 (1) (see all 7)
glioblastoma	15.62	2	17951409 (1), 16412397 (1)
colon carcinoma	14.08	2	16715134 (1), 17178865 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/914 PubMed articles for RHOA gene (see all 914 ):

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)^{1, 3, 4} Arthur W.T.... Wennerberg K. (2002)
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353)^{1, 3, 4} Klussmann E.... Rosenthal W. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. (PubMed id 12538863)^{3, 4} Shao F.... Dixon J.E. (2003)
Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. (PubMed id 12777804)^{3, 4} Longenecker K....Derewenda Z.S. (2003)
Direct activation of phospholipase C-epsilon by Rho. (PubMed id 12900402)^{3, 4} Wing M.R.... Harden T.K. (2003)
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. (PubMed id 12006984)^{3, 4} Snyder J.T.... Sondek J. (2002)
MgF(3)(-) as a transition state analog of phosphoryl transfer. (PubMed id 11927263)^{3, 4} Graham D.L.... Eccleston J.F. (2002)
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. (PubMed id 12062101)^{3, 4} Shao F.... Dixon J.E. (2002)
The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PubMed id 10940294)^{3, 4} Reynaud C....Jalinot P. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 387	HGNC: 667	AceView: RHOA	Ensembl:ENSG00000067560	euGenes: HUgn387
ECgene: RHOA	H-InvDB: RHOA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RHOA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RHOA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RHOA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RHOA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RHOA		Antibodies for RHOA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RHOA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RHOA)
	Antibodies (RHOA)
	Chimera RNAi (RHOA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RHOA

	Recombinant Proteins (Rho, RhoA, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)
	Antibodies (Rho, RhoA, Rho A + B + C, Pan Rho + RAC (1,2,3) + CDC42)

Search OriGene for RHOA

Search Tocris compounds for RHOA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RHOA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RHOA Gene at Home site.
Version 2.41.1
server5.xennexinc.com

RHOA Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for RHOA

Summaries
for RHOA

Genomic Location
for RHOA

Proteins
for RHOA

Protein Domains/
Families
for RHOA

Gene Function
for RHOA

Pathways & Interactions
for RHOA

Drugs & Compounds
for RHOA

Transcripts
for RHOA

Expression
for RHOA

Orthologs
for RHOA

Paralogs
for RHOA

SNPs/Variants
for RHOA

Disorders & Mutations
for RHOA

Medical News
for RHOA

Publications
for RHOA

Search for RHOA

Genome Databases showing RHOA

Other Databases showing RHOA

Specialized Databases showing RHOA

Licensable Technologies
for RHOA

Services
for RHOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RHOA Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor RHOA

Summariesfor RHOA

Genomic Locationfor RHOA

Proteinsfor RHOA

Protein Domains/Familiesfor RHOA

Gene Functionfor RHOA

Pathways & Interactionsfor RHOA

Drugs & Compoundsfor RHOA

Transcriptsfor RHOA

Expression for RHOA

Orthologsfor RHOA

Paralogsfor RHOA

SNPs/Variantsfor RHOA

Disorders & Mutationsfor RHOA

Medical Newsfor RHOA

Publicationsfor RHOA

Search for RHOA

Genome Databases showing RHOA

Other Databases showing RHOA

Specialized Databases showing RHOA

Licensable Technologiesfor RHOA

Servicesfor RHOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RHOA

Summaries
for RHOA

Genomic Location
for RHOA

Proteins
for RHOA

Protein Domains/
Families
for RHOA

Gene Function
for RHOA

Pathways & Interactions
for RHOA

Drugs & Compounds
for RHOA

Transcripts
for RHOA

Expression
for RHOA

Orthologs
for RHOA

Paralogs
for RHOA

SNPs/Variants
for RHOA

Disorders & Mutations
for RHOA

Medical News
for RHOA

Publications
for RHOA

Licensable Technologies
for RHOA

Services
for RHOA