ARGLU1 Gene
protein-coding GIFtS: 47
GCID: GC13M107194
|
|
arginine and glutamate rich 1
| |
Aliases
for ARGLU1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arginine And Glutamate Rich 11 2 | | FLJ101541 | | Arginine And Glutamate-Rich Protein 12 |
Export aliases for ARGLU1 gene to outside databasesPrevious GC identifers: GC13M105992 GC13M087787 |
Summaries
for ARGLU1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1
|
Genomic Views
for ARGLU1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARGLU1 gene promoter:
MAZR POU3F2 (N-Oct-5b) FOXL1 AREB6 E2F-1 E2F FOXO4 Chx10 ZID Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARGLU1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGLU1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q33.3 Ensembl cytogenetic band: 13q33.3 HGNC cytogenetic band: 13q33.3ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M107194: view genomic region
(about GC identifiers)
Start:
|
107,194,021 bp from pter |
End:
|
107,220,514 bp from pter |
Size:
|
26,494 bases |
Orientation:
|
minus strand |
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Proteins
for ARGLU1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6 (See
protein sequence)Recommended Name: Arginine and glutamate-rich protein 1 Size: 273 amino acids; 33216 Da
Subunit: Directly interacts with MED1
Subcellular location: Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters.Colocalizes with MED1
Sequence caution: Sequence=CAI13166.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T257 Q6IQ34Alternative splicing: 2 isoforms: Q9NWB6-1 Q9NWB6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARGLU1: NX_Q9NWB6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWB6
ARGLU1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060481.3
ENSEMBL proteins: ENSP00000383059 ENSP00000365092 ENSP00000353844
Human Recombinant Protein Products for ARGLU1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ARGLU1 for ontologies About GeneDecksing
ARGLU1 Antibody Products:
Assay Products for ARGLU1: |
Protein
Domains /
Families
for ARGLU1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NWB6 UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6Similarity: Belongs to the UPF0430 family |
Function
for ARGLU1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ARGL1_HUMAN, Q9NWB6Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1Phenotypes:
2 GenomeRNAi human phenotypes for ARGLU1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARGLU1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARGLU1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARGLU1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1 |
|
Pathways & Interactions
for ARGLU1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARGLU1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/539 Interacting proteins for ARGLU1 (Q9NWB62, 3 ENSP000003830594) via UniProtKB, MINT, STRING, and/or I2D (see all 539)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ARGLU1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARGLU1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARGLU1
Search CenterWatch for drugs/clinical trials and news about ARGLU1 / ARGL1
|
Transcripts
for ARGLU1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARGLU1 gene: NM_018011.3 Unigene Cluster for ARGLU1: Arginine and glutamate rich 1 Hs.743957 [show with all ESTs]Unigene Representative Sequence: CR9367484 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000400198(uc001vqk.4) ENST00000472226 ENST00000375926(uc010age.1)
ENST00000360629
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARGLU1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARGLU1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARGLU1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1 |
Additional cDNA sequence: AK001016.1 AK303575.1 AK304751.1 AK309941.1 BC030508.1 BC050434.1 CR936748.1 DQ866757.1 24 DOTS entries: DT.100882898 DT.91954034 DT.91848333 DT.87017709 DT.95153709 DT.70105451 DT.91886666 DT.92445951 DT.91730956 DT.100044012 DT.100882897 DT.120773642 DT.120773661 DT.95081032 DT.95226673 DT.120773718 DT.121634619 DT.100708163 DT.100882899 DT.120773632 DT.91642433 DT.100882902 DT.91807054 DT.95226672 24/439 AceView cDNA sequences (see all 439): AI889343 AW026935 AI538785 AW029628 BX096061 AW075468 AA045813 AI204045 BU176969 BM510884 AI051916 AW779743 AI308963 AI368764 AA971914 AA503209 CB148576 AU118350 AW071905 BM508163 CR625403 AW866552 CB150888 BM680196
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARGLU1
|
Expression
for ARGLU1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARGLU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAGTGGT
About this image
See ARGLU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARGLU1
SOURCE GeneReport for Unigene cluster: Hs.743957
SABiosciences Custom PCR Arrays for ARGLU1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARGLU1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARGLU1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGLU1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1 |
Orthologs
for ARGLU1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARGLU1 gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for ARGLU1 (if available)
TreeFam Gene Tree for ARGLU1 (if available) |
Paralogs
for ARGLU1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARGLU1 gene
- DDX232
ARGLU1 for paralogs About GeneDecksing
|
Genomic Variants
for ARGLU1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARGLU1 (107194021 - 107220514 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARGLU1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARGLU1 |
|
Disorders
/ Diseases
for ARGLU1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARGLU1 for disorders About GeneDecksing
OMIM gene information: 614046
OMIM disorders: --
3  diseases for ARGLU1: About MalaCardscrescentic glomerulonephritis glomerulonephritis breast cancer
1 disease from the University of Copenhagen DISEASES database for ARGLU1:Crescentic glomerulonephritis Human Genome Epidemiology (HuGE) Navigator: ARGLU1 (1 document)
Export disorders for ARGLU1 gene to outside databases
|
Publications
for ARGLU1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARGLU1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ARGLU1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PubMed id 21454576)1, 2, 3 Zhang D....Zhang X. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ARGLU1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARGLU1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARGLU1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARGLU1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARGLU1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARGLU1 gene:
Search GeneIP for patents involving ARGLU1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARGLU1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARGLU1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARGLU1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGLU1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARGLU1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGLU1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1 |
| |
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| |  |  |  |  | | | | |
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 | | | ARGLU1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1 |
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