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ARGLU1 Gene

protein-coding   GIFtS: 51
GCID: GC13M107194

Arginine And Glutamate Rich 1

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginine And Glutamate Rich 11 2
Arginine And Glutamate-Rich Protein 12

External Ids:    HGNC: 254821   Entrez Gene: 550822   Ensembl: ENSG000001348847   OMIM: 6140465   UniProtKB: Q9NWB63   

Export aliases for ARGLU1 gene to outside databases

Previous GC identifers: GC13M105992 GC13M087787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARGLU1 Gene:
ARGLU1 (arginine and glutamate rich 1) is a protein-coding gene. Diseases associated with ARGLU1 include crescentic glomerulonephritis, and glomerulonephritis.

UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6
Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARGLU1 gene promoter:
         MAZR   POU3F2 (N-Oct-5b)   FOXL1   AREB6   E2F-1   E2F   FOXO4   Chx10   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARGLU1 promoter sequence
   Search Chromatin IP Primers for ARGLU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARGLU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.3   Ensembl cytogenetic band:  13q33.3   HGNC cytogenetic band: 13q33.3

ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARGLU1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M107194:  view genomic region     (about GC identifiers)

Start:
107,194,021 bp from pter      End:
107,220,514 bp from pter
Size:
26,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6 (See protein sequence)
Recommended Name: Arginine and glutamate-rich protein 1  
Size: 273 amino acids; 33216 Da
Subunit: Directly interacts with MED1
Sequence caution: Sequence=CAI13166.1; Type=Erroneous gene model prediction;
Secondary accessions: B4E0Y3 Q5T257 Q6IQ34
Alternative splicing: 3 isoforms:  Q9NWB6-1   Q9NWB6-2   Q9NWB6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARGLU1: NX_Q9NWB6

Explore proteomics data for ARGLU1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys270
  • Modification sites at PhosphoSitePlus

  • See ARGLU1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060481.3  
    ENSEMBL proteins: 
     ENSP00000383059   ENSP00000365092   ENSP00000353844  

    ARGLU1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ARGLU1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NWB6

    UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6
    Similarity: Belongs to the UPF0430 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARGL1_HUMAN, Q9NWB6
    Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    ARGLU1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARGLU1:
     Decreased Tat-dependent transc  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARGLU1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARGLU1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARGLU1

    miRNA
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    miRTarBase miRNAs that target ARGLU1:
    hsa-mir-32-5p (MIRT028287), hsa-mir-877-3p (MIRT037100), hsa-mir-1 (MIRT024091), hsa-mir-155-5p (MIRT021029)

    Block miRNA regulation of human, mouse, rat ARGLU1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARGLU1 (see all 23):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-520d-5p hsa-miR-2110 hsa-miR-421 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidARGLU1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARGLU1
    Predesigned siRNA for gene silencing in human, mouse, rat ARGLU1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ARGLU1

    Clone
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    OriGene clones in human, mouse for ARGLU1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARGLU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARGL1_HUMAN, Q9NWB6: Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters.
    Colocalizes with MED1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--

    ARGLU1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARGLU1
    Interactions:

        Search GeneGlobe Interaction Network for ARGLU1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARGLU1 (Q9NWB61, 2, 3 ENSP000003830594) via UniProtKB, MINT, STRING, and/or I2D (see all 591)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRPK2P783621, 2, ENSP000003772624EBI-2808785,EBI-593303 MINT-8338828 STRING: ENSP00000377262
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    ZCCHC10Q8TBK62, ENSP000003242744MINT-8338817 STRING: ENSP00000324274
    CHERPQ8IWX82, ENSP000001989394MINT-8334692 STRING: ENSP00000198939
    SART1O432902, ENSP000003104484MINT-7947479 STRING: ENSP00000310448
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ARGLU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARGLU1 (ARGL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARGLU1 gene: 
    NM_018011.3  

    Unigene Cluster for ARGLU1:

    Arginine and glutamate rich 1
    Hs.508644  [show with all ESTs]
    Unigene Representative Sequence: CR936748
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400198(uc001vqk.4) ENST00000472226 ENST00000375926(uc010age.1)
    ENST00000360629

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARGLU1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARGLU1 (see all 23):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-520d-5p hsa-miR-2110 hsa-miR-421 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidARGLU1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARGLU1
    Predesigned siRNA for gene silencing in human, mouse, rat ARGLU1
    Clone
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    OriGene clones in human, mouse for ARGLU1 (see all 6)
    OriGene ORF clones in mouse, rat for ARGLU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARGLU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARGLU1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARGLU1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARGLU1
      QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1
      QuantiFast Probe-based Assays in human, mouse, rat ARGLU1

    Additional mRNA sequence: 

    AK001016.1 AK303575.1 AK304751.1 AK309941.1 BC030508.1 BC050434.1 CR936748.1 DQ866757.1 

    Selected DOTS entries (see all 25):

    DT.100882898  DT.91954034  DT.91848333  DT.87017709  DT.95153709  DT.70105451  DT.91886666  DT.92445951 
    DT.91730956  DT.100044012  DT.100882897  DT.120773642  DT.120773661  DT.95081032  DT.95226673  DT.120773718 
    DT.121634619  DT.100708163  DT.100882899  DT.100882902  DT.120773632  DT.120773643  DT.91642433  DT.91807054 

    Selected AceView cDNA sequences (see all 439):

    BI966834 AW004902 BQ894717 AI308963 AI538785 AW337425 AI889343 AI625562 
    AI690643 AI559732 L13833 AI051916 AI332893 CA411957 BI325009 AI675264 
    AA604982 AI559603 AI572985 BE464947 AI360608 N35376 AA678488 AA486625 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -           -     -     -           -                                 
    SP2:                    -           -     -     -     -     -                                 
    SP3:                                                        -                                 
    SP4:                                                                                          
    SP5:                    -                                                                     


    ECgene alternative splicing isoforms for ARGLU1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARGLU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGTGGT
    ARGLU1 Expression
    About this image


    ARGLU1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ARGLU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARGLU1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508644
        Custom PCR Arrays for ARGLU1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARGLU1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arglu11 , 5 arginine and glutamate rich 11, 5 93.6(n)1
    99.26(a)1
      8 (3.57 cM)5
    2340231  NM_176849.31  NP_789819.21 
     86665775 
    chicken
    (Gallus gallus)
    Aves ARGLU11 arginine and glutamate rich 1 86.15(n)
    93.75(a)
      418765  NM_001006267.1  NP_001006267.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARGLU16
    arginine and glutamate rich 1
    92(a)
    1 ↔ 1
    3(103618495-103632261)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC763032 hypothetical protein MGC76303 81.25(n)    BC064271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555482 hypothetical protein MGC55548 75.36(n)   393131  BC045379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317126
    --
    46(a)
    1 ↔ 1
    2L(9934767-9938134)


    ENSEMBL Gene Tree for ARGLU1 (if available)
    TreeFam Gene Tree for ARGLU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARGLU1 (see all 538)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440249051,2
    --107195257(+) GACTCC/GACCAT 1 -- int10--------
    rs1850004511,2
    --107195410(+) CACAGG/TTTTGA 1 -- int10--------
    rs1467435241,2
    --107195506(+) AAAAAG/TAGCCA 1 -- int10--------
    rs1911578791,2
    --107195591(+) GTTCTA/GAGACT 1 -- int10--------
    rs771339481,2
    C,F--107195689(+) GACTTT/GACTTT 1 -- ut311Minor allele frequency- G:0.06EA 120
    rs115451561,2
    C,H--107195760(+) AAAAAC/AAAAAT 1 -- ut312Minor allele frequency- A:0.01NS NA 182
    rs1820538121,2
    --107195761(+) AAAACA/GAAATG 1 -- ut310--------
    rs10594171,2
    C,F,H--107195806(-) CAACTC/TTGATA 1 -- ut315Minor allele frequency- T:0.00MN NS NA 594
    rs1483366941,2
    --107196022(+) AGTCAG/TTGGGG 1 -- ut310--------
    rs1414689091,2
    --107196023(+) GTCAGA/TGGGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARGLU1 (107194021 - 107220514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARGLU1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1172CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARGLU1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARGLU1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614046    OMIM disorders: --

    5 diseases for ARGLU1:    
    About MalaCards
    crescentic glomerulonephritis    glomerulonephritis    hiv-1    malaria
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ARGLU1:
    Crescentic glomerulonephritis

    ARGLU1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): ARGLU1
    Human Genome Epidemiology (HuGE) Navigator: ARGLU1 (1 document)

    Export disorders for ARGLU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARGLU1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ARGLU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PubMed id 21454576)1, 2, 3 Zhang D.... Zhang X. (J. Biol. Chem. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    6. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55082 HGNC: 25482 AceView: FLJ10154 Ensembl:ENSG00000134884 euGenes: HUgn55082
    ECgene: ARGLU1 H-InvDB: ARGLU1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARGLU1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARGLU1 gene:
    Search GeneIP for patents involving ARGLU1

    GeneCards and IP:
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