Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARGLU1 Gene

protein-coding   GIFtS: 49
GCID: GC13M107194

Arginine And Glutamate Rich 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arginine And Glutamate Rich 11 2
Arginine And Glutamate-Rich Protein 12

External Ids:    HGNC: 254821   Entrez Gene: 550822   Ensembl: ENSG000001348847   OMIM: 6140465   UniProtKB: Q9NWB63   

Export aliases for ARGLU1 gene to outside databases

Previous GC identifers: GC13M105992 GC13M087787


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARGLU1 Gene: 
ARGLU1 (arginine and glutamate rich 1) is a protein-coding gene. Diseases associated with ARGLU1 include crescentic glomerulonephritis, and glomerulonephritis.

UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6
Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARGLU1 gene promoter:
         MAZR   POU3F2 (N-Oct-5b)   FOXL1   AREB6   E2F-1   E2F   FOXO4   Chx10   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARGLU1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARGLU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGLU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.3   Ensembl cytogenetic band:  13q33.3   HGNC cytogenetic band: 13q33.3

ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARGLU1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M107194:  view genomic region     (about GC identifiers)

Start:
107,194,021 bp from pter      End:
107,220,514 bp from pter
Size:
26,494 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6 (See protein sequence)
Recommended Name: Arginine and glutamate-rich protein 1  
Size: 273 amino acids; 33216 Da
Subunit: Directly interacts with MED1
Subcellular location: Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters.
Colocalizes with MED1
Sequence caution: Sequence=CAI13166.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T257 Q6IQ34
Alternative splicing: 2 isoforms:  Q9NWB6-1   Q9NWB6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARGLU1: NX_Q9NWB6

Explore proteomics data for ARGLU1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWB6

  • ARGLU1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARGLU1 Protein Expression
    REFSEQ proteins: NP_060481.3  
    ENSEMBL proteins: 
     ENSP00000383059   ENSP00000365092   ENSP00000353844  

    Human Recombinant Protein Products for ARGLU1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARGLU1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ARGLU1
    GenScript Custom Purified and Recombinant Proteins Services for ARGLU1
    Novus Biologicals ARGLU1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARGLU1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ARGLU1 for ontologies           About GeneDecksing



    ARGLU1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARGLU1
    GenScript Custom Superior Antibodies Services for ARGLU1
    Novus Biologicals ARGLU1 Antibodies
    Abcam antibodies for ARGLU1
    Cloud-Clone Corp. Antibodies for ARGLU1 
    ThermoFisher Antibody for ARGLU1
    LSBio Antibodies in human, mouse, rat for ARGLU1 

    Assay Products for ARGLU1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARGLU1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARGLU1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARGLU1 
    Cloud-Clone Corp. CLIAs for ARGLU1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NWB6

    UniProtKB/Swiss-Prot: ARGL1_HUMAN, Q9NWB6
    Similarity: Belongs to the UPF0430 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARGL1_HUMAN, Q9NWB6
    Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    ARGLU1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARGLU1:
     Decreased Tat-dependent transc  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARGLU1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARGLU1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARGLU1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARGLU1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARGLU1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ARGLU1 (see all 23):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-520d-5p hsa-miR-2110 hsa-miR-421 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidARGLU1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARGLU1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARGLU1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARGLU1
    Sirion Biotech Customized adenovirus for overexpression of ARGLU1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARGLU1 (see all 7)
    OriGene ORF clones in mouse, rat for ARGLU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARGLU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1
    Sirion Biotech Customized lentivirus for stable overexpression of ARGLU1 
                         Customized lentivirus expression plasmids for stable overexpression of ARGLU1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARGLU1
    Search LifeMap BioReagents cell lines for ARGLU1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARGLU1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/566 Interacting proteins for ARGLU1 (Q9NWB62, 3 ENSP000003830594) via UniProtKB, MINT, STRING, and/or I2D (see all 566)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    ZCCHC10Q8TBK62, ENSP000003242744MINT-8338817 STRING: ENSP00000324274
    SRPK2P783622, ENSP000003772624MINT-8338828 STRING: ENSP00000377262
    CHERPQ8IWX82, ENSP000001989394MINT-8334692 STRING: ENSP00000198939
    SART1O432902, ENSP000003104484MINT-7947479 STRING: ENSP00000310448
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ARGLU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARGLU1 (ARGL1)

    Search CenterWatch for drugs/clinical trials and news about ARGLU1 / ARGL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARGLU1 gene: 
    NM_018011.3  

    Unigene Cluster for ARGLU1:

    Arginine and glutamate rich 1
    Hs.508644  [show with all ESTs]
    Unigene Representative Sequence: CR936748
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400198(uc001vqk.4) ENST00000472226 ENST00000375926(uc010age.1)
    ENST00000360629
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARGLU1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ARGLU1 (see all 23):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-520d-5p hsa-miR-2110 hsa-miR-421 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidARGLU1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARGLU1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARGLU1
    Clone
    Products:
         
    OriGene clones in human, mouse for ARGLU1 (see all 7)
    OriGene ORF clones in mouse, rat for ARGLU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARGLU1 (NM_018011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARGLU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1
    Sirion Biotech Customized lentivirus for stable overexpression of ARGLU1 
                         Customized lentivirus expression plasmids for stable overexpression of ARGLU1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARGLU1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARGLU1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARGLU1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGLU1

    Additional mRNA sequence: 

    AK001016.1 AK303575.1 AK304751.1 AK309941.1 BC030508.1 BC050434.1 CR936748.1 DQ866757.1 

    24/25 DOTS entries (see all 25):

    DT.100882898  DT.91954034  DT.91848333  DT.87017709  DT.95153709  DT.70105451  DT.91886666  DT.92445951 
    DT.91730956  DT.100044012  DT.100882897  DT.120773642  DT.120773661  DT.95081032  DT.95226673  DT.120773718 
    DT.121634619  DT.100708163  DT.100882899  DT.100882902  DT.120773632  DT.120773643  DT.91642433  DT.91807054 

    24/439 AceView cDNA sequences (see all 439):

    T10825 AJ706651 AA457133 AI538785 AW173701 L13833 BI325009 AI675264 
    AA604982 AI559603 AI572985 BE464947 AI360608 N35376 AA678488 AA486625 
    BQ016211 AA460057 BM511143 AA333500 AI368764 AL045916 BE467531 AI381892 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -           -     -     -           -                                 
    SP2:                    -           -     -     -     -     -                                 
    SP3:                                                        -                                 
    SP4:                                                                                          
    SP5:                    -                                                                     


    ECgene alternative splicing isoforms for ARGLU1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARGLU1 expression in normal human tissues (normalized intensities)      ARGLU1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGTGGT
    ARGLU1 Expression
    About this image


    ARGLU1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Spleen (Hematopoietic System)

    See ARGLU1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARGLU1

    SOURCE GeneReport for Unigene cluster: Hs.508644
        SABiosciences Custom PCR Arrays for ARGLU1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARGLU1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARGLU1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARGLU1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGLU1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARGLU1 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arglu11 , 5 arginine and glutamate rich 11, 5 93.6(n)1
    99.26(a)1
      8 (3.57 cM)5
    2340231  NM_176849.31  NP_789819.21 
     86665775 
    chicken
    (Gallus gallus)
    Aves ARGLU11 arginine and glutamate rich 1 87.67(n)
    96.34(a)
      418765  NM_001006267.1  NP_001006267.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARGLU16
    Uncharacterized protein
    92(a)
    1 ↔ 1
    3(103618495-103632261)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC763032 hypothetical protein MGC76303 81.25(n)    BC064271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555482 hypothetical protein MGC55548 75.36(n)   393131  BC045379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317121 CG31712 51.59(n)
    53.57(a)
      34320  NM_135483.4  NP_609327.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC36
    Subunit of the exocyst complex (Sec3p, Sec5p, Sec6...
    1(a)
    1 → many
    V(167808-171818)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G108901 arginine and glutamate-rich protein 1 45.08(n)
    39.46(a)
      837632  NM_100964.4  NP_172558.4 
    rice
    (Oryza sativa)
    Liliopsida Os11g05442001 hypothetical protein 50.55(n)
    46.36(a)
      4350681  NM_001074583.1  NP_001068051.1 


    ENSEMBL Gene Tree for ARGLU1 (if available)
    TreeFam Gene Tree for ARGLU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/538 SNPs in ARGLU1 are shown (see all 538)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440249051,2
    --107195257(+) GACTCC/GACCAT 1 -- int10--------
    rs1850004511,2
    --107195410(+) CACAGG/TTTTGA 1 -- int10--------
    rs1467435241,2
    --107195506(+) AAAAAG/TAGCCA 1 -- int10--------
    rs1911578791,2
    --107195591(+) GTTCTA/GAGACT 1 -- int10--------
    rs771339481,2
    C,F--107195689(+) GACTTT/GACTTT 1 -- ut311Minor allele frequency- G:0.06EA 120
    rs115451561,2
    C,H--107195760(+) AAAAAC/AAAAAT 1 -- ut312Minor allele frequency- A:0.01NS NA 182
    rs1820538121,2
    --107195761(+) AAAACA/GAAATG 1 -- ut310--------
    rs10594171,2
    C,F,H--107195806(-) CAACTC/TTGATA 1 -- ut315Minor allele frequency- T:0.00MN NS NA 594
    rs1483366941,2
    --107196022(+) AGTCAG/TTGGGG 1 -- ut310--------
    rs1414689091,2
    --107196023(+) GTCAGA/TGGGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARGLU1 (107194021 - 107220514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARGLU1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1172CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARGLU1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARGLU1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614046    OMIM disorders: --

    3 diseases for ARGLU1:    About MalaCards
    crescentic glomerulonephritis    glomerulonephritis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ARGLU1:
    Crescentic glomerulonephritis

    ARGLU1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARGLU1
    Human Genome Epidemiology (HuGE) Navigator: ARGLU1 (1 document)

    Export disorders for ARGLU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARGLU1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ARGLU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PubMed id 21454576)1, 2, 3 Zhang D....Zhang X. (2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    4. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    5. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Genome-wide association scan of trait depression. (PubMed id 20800221)4 Terracciano A....Costa P.T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55082 HGNC: 25482 AceView: FLJ10154 Ensembl:ENSG00000134884 euGenes: HUgn55082
    ECgene: ARGLU1 H-InvDB: ARGLU1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARGLU1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARGLU1 gene:
    Search GeneIP for patents involving ARGLU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARGLU1  
     OriGene qPCR primer pairs and template standards for ARGLU1   OriGene Protein Over-expression Lysate for ARGLU1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARGLU1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARGLU1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARGLU1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARGLU1   OriGene Custom Protein Services for ARGLU1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARGLU1
     QIAGEN SeqTarget long-range PCR primers for resequencing ARGLU1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGLU1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARGLU1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGLU1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGLU1
     GenScript Custom Purified and Recombinant Proteins Services for ARGLU1 GenScript cDNA clones with any tag delivered in your preferred vector for ARGLU1
     GenScript Custom Assay Services for ARGLU1 GenScript Custom Superior Antibodies Services for ARGLU1
     GenScript Custom overexpressing Cell Line Services for ARGLU1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARGLU1 promoter
     Search Chromatin IP Primers for ARGLU1
     RT2 qPCR Primer Assay in human, mouse, rat ARGLU1
     Search GNC Networks for ARGLU1
     SABiosciences Custom PCR Arrays for ARGLU1
     Search Tocris compounds for ARGLU1 (ARGL1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARGLU1 antibodies
     ARGLU1 lysates
     Antibodies for ARGLU1
     See all of Abcam's Antibodies, Kits and Proteins for ARGLU1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARGLU1
     Antibodies for ARGLU1
     ELISAs for ARGLU1
     CLIAs for ARGLU1
     Search LifeMap BioReagents cell lines for ARGLU1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGLU1
     SwitchGear 3'UTR luciferase reporter plasmids for ARGLU1
     SwitchGear Promoter luciferase reporter plasmids for ARGLU1
     ThermoFisher Antibody for ARGLU1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARGLU1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARGLU1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARGLU1
    Customized:
     lentivirus for stable overexpression of ARGLU1
     lentivirus expression plasmids for stable overexpression of ARGLU1
     adenovirus for overexpression of ARGLU1
     LSBio Antibodies in human, mouse, rat for ARGLU1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARGLU1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4