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Aliases for ARGLU1 Gene

Aliases for ARGLU1 Gene

  • Arginine And Glutamate Rich 1 2 3

External Ids for ARGLU1 Gene

Summaries for ARGLU1 Gene

GeneCards Summary for ARGLU1 Gene

ARGLU1 (Arginine And Glutamate Rich 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ARGLU1 Gene

  • Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGLU1 Gene

Genomics for ARGLU1 Gene

Genomic Location for ARGLU1 Gene

106,541,673 bp from pter
106,568,166 bp from pter
26,494 bases
Minus strand

Genomic View for ARGLU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARGLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGLU1 Gene

Regulatory Elements for ARGLU1 Gene

Proteins for ARGLU1 Gene

  • Protein details for ARGLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine and glutamate-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E0Y3
    • Q5T257
    • Q6IQ34

    Protein attributes for ARGLU1 Gene

    273 amino acids
    Molecular mass:
    33216 Da
    Quaternary structure:
    • Directly interacts with MED1.
    • Sequence=CAI13166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARGLU1 Gene


neXtProt entry for ARGLU1 Gene

Proteomics data for ARGLU1 Gene at MOPED

Post-translational modifications for ARGLU1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys270

Other Protein References for ARGLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGLU1 Gene

Domains for ARGLU1 Gene

Protein Domains for ARGLU1 Gene


Suggested Antigen Peptide Sequences for ARGLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0430 family.:
    • Q9NWB6
genes like me logo Genes that share domains with ARGLU1: view

No data available for Gene Families for ARGLU1 Gene

Function for ARGLU1 Gene

Molecular function for ARGLU1 Gene

UniProtKB/Swiss-Prot Function: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Gene Ontology (GO) - Molecular Function for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with ARGLU1: view

Phenotypes for ARGLU1 Gene

GenomeRNAi human phenotypes for ARGLU1:
genes like me logo Genes that share phenotypes with ARGLU1: view

miRNA for ARGLU1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARGLU1 Gene

Localization for ARGLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGLU1 Gene

Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

Subcellular locations from

Jensen Localization Image for ARGLU1 Gene COMPARTMENTS Subcellular localization image for ARGLU1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ARGLU1: view

Pathways for ARGLU1 Gene

SuperPathways for ARGLU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARGLU1: view

No data available for Pathways by source for ARGLU1 Gene

Transcripts for ARGLU1 Gene

mRNA/cDNA for ARGLU1 Gene

Unigene Clusters for ARGLU1 Gene

Arginine and glutamate rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP5: -

Relevant External Links for ARGLU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARGLU1 Gene

mRNA expression in normal human tissues for ARGLU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARGLU1 Gene

SOURCE GeneReport for Unigene cluster for ARGLU1 Gene Hs.508644

genes like me logo Genes that share expressions with ARGLU1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARGLU1 Gene

Orthologs for ARGLU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARGLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARGLU1 35
  • 99.76 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ARGLU1 35
  • 95.85 (n)
  • 100 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ARGLU1 35
  • 94.63 (n)
  • 98.17 (a)
  • 97 (a)
(Mus musculus)
Mammalia Arglu1 35
  • 93.6 (n)
  • 99.26 (a)
Arglu1 16
Arglu1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ARGLU1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Arglu1 35
  • 93.6 (n)
  • 99.26 (a)
(Gallus gallus)
Aves ARGLU1 35
  • 86.15 (n)
  • 93.75 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia ARGLU1 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arglu1 35
  • 82.77 (n)
  • 95.47 (a)
MGC76303 35
(Danio rerio)
Actinopterygii arglu1a 36
  • 82 (a)
arglu1b 35
  • 74.47 (n)
  • 88.48 (a)
arglu1b 36
  • 87 (a)
zgc55548 35
fruit fly
(Drosophila melanogaster)
Insecta CG31712 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8765 36
  • 52 (a)
Species with no ortholog for ARGLU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARGLU1 Gene

Gene Tree for ARGLU1 (if available)
Gene Tree for ARGLU1 (if available)

Paralogs for ARGLU1 Gene

No data available for Paralogs for ARGLU1 Gene

Variants for ARGLU1 Gene

Sequence variations from dbSNP and Humsavar for ARGLU1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11339 -- 106,543,371(+) TTACA(C/G)AATGG utr-variant-3-prime, nc-transcript-variant
rs15449 -- 106,543,406(+) TGAAA(A/T)AAAAA utr-variant-3-prime, nc-transcript-variant
rs942333 -- 106,558,744(+) TGTTC(C/T)TTCAT intron-variant, nc-transcript-variant
rs1059417 -- 106,543,458(-) CAACT(C/T)TGATA utr-variant-3-prime, nc-transcript-variant
rs2391343 -- 106,551,661(+) gggct(C/G)aaagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARGLU1 Gene

Variant ID Type Subtype PubMed ID
nsv1172 CNV Insertion 18451855

Relevant External Links for ARGLU1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARGLU1 Gene

Disorders for ARGLU1 Gene

(1) University of Copenhagen DISEASES for ARGLU1 Gene

Relevant External Links for ARGLU1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARGLU1: view

No data available for UniProtKB/Swiss-Prot for ARGLU1 Gene

Publications for ARGLU1 Gene

  1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PMID: 21454576) Zhang D. … Zhang X. (J. Biol. Chem. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PMID: 17332742) Behzadnia N. … Luehrmann R. (EMBO J. 2007) 3

Products for ARGLU1 Gene

Sources for ARGLU1 Gene

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