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Aliases for ARGLU1 Gene

Aliases for ARGLU1 Gene

  • Arginine And Glutamate Rich 1 2 3 5

External Ids for ARGLU1 Gene

Previous GeneCards Identifiers for ARGLU1 Gene

  • GC13M105992
  • GC13M107194
  • GC13M087787

Summaries for ARGLU1 Gene

GeneCards Summary for ARGLU1 Gene

ARGLU1 (Arginine And Glutamate Rich 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ARGLU1 Gene

  • Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGLU1 Gene

Genomics for ARGLU1 Gene

Regulatory Elements for ARGLU1 Gene

Enhancers for ARGLU1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARGLU1 on UCSC Golden Path with GeneCards custom track

Promoters for ARGLU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARGLU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARGLU1 Gene

106,541,673 bp from pter
106,568,166 bp from pter
26,494 bases
Minus strand

Genomic View for ARGLU1 Gene

Genes around ARGLU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARGLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGLU1 Gene

Proteins for ARGLU1 Gene

  • Protein details for ARGLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine and glutamate-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E0Y3
    • Q5T257
    • Q6IQ34

    Protein attributes for ARGLU1 Gene

    273 amino acids
    Molecular mass:
    33216 Da
    Quaternary structure:
    • Directly interacts with MED1.
    • Sequence=CAI13166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARGLU1 Gene


neXtProt entry for ARGLU1 Gene

Proteomics data for ARGLU1 Gene at MOPED

Post-translational modifications for ARGLU1 Gene

  • Ubiquitination at Lys 270
  • Modification sites at PhosphoSitePlus

Other Protein References for ARGLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGLU1 Gene

Domains & Families for ARGLU1 Gene

Protein Domains for ARGLU1 Gene


Suggested Antigen Peptide Sequences for ARGLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0430 family.
  • Belongs to the UPF0430 family.
genes like me logo Genes that share domains with ARGLU1: view

No data available for Gene Families for ARGLU1 Gene

Function for ARGLU1 Gene

Molecular function for ARGLU1 Gene

UniProtKB/Swiss-Prot Function:
Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Phenotypes for ARGLU1 Gene

genes like me logo Genes that share phenotypes with ARGLU1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARGLU1 Gene

Localization for ARGLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGLU1 Gene

Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

Subcellular locations from

Jensen Localization Image for ARGLU1 Gene COMPARTMENTS Subcellular localization image for ARGLU1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ARGLU1: view

Pathways & Interactions for ARGLU1 Gene

SuperPathways for ARGLU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARGLU1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARGLU1 Gene

Drugs & Compounds for ARGLU1 Gene

No Compound Related Data Available

Transcripts for ARGLU1 Gene

Unigene Clusters for ARGLU1 Gene

Arginine and glutamate rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP5: -

Relevant External Links for ARGLU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARGLU1 Gene

mRNA expression in normal human tissues for ARGLU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARGLU1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Spleen (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARGLU1 Gene

SOURCE GeneReport for Unigene cluster for ARGLU1 Gene Hs.508644

genes like me logo Genes that share expression patterns with ARGLU1: view

Protein tissue co-expression partners for ARGLU1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARGLU1 Gene

Orthologs for ARGLU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARGLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARGLU1 35
  • 95.85 (n)
  • 100 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ARGLU1 35
  • 94.63 (n)
  • 98.17 (a)
  • 97 (a)
(Mus musculus)
Mammalia Arglu1 35
  • 93.6 (n)
  • 99.26 (a)
Arglu1 16
Arglu1 36
  • 99 (a)
(Pan troglodytes)
Mammalia ARGLU1 35
  • 99.76 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arglu1 35
  • 93.6 (n)
  • 99.26 (a)
(Monodelphis domestica)
Mammalia ARGLU1 36
  • 97 (a)
(Gallus gallus)
Aves ARGLU1 35
  • 86.15 (n)
  • 93.75 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia ARGLU1 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arglu1 35
  • 82.77 (n)
  • 95.47 (a)
MGC76303 35
(Danio rerio)
Actinopterygii arglu1b 35
  • 74.47 (n)
  • 88.48 (a)
zgc55548 35
arglu1a 36
  • 82 (a)
arglu1b 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31712 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8765 36
  • 52 (a)
Species with no ortholog for ARGLU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARGLU1 Gene

Gene Tree for ARGLU1 (if available)
Gene Tree for ARGLU1 (if available)

Paralogs for ARGLU1 Gene

No data available for Paralogs for ARGLU1 Gene

Variants for ARGLU1 Gene

Sequence variations from dbSNP and Humsavar for ARGLU1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs11339 -- 106,543,371(+) TTACA(C/G)AATGG nc-transcript-variant, utr-variant-3-prime
rs15449 -- 106,543,406(+) TGAAA(A/T)AAAAA nc-transcript-variant, utr-variant-3-prime
rs942333 -- 106,558,744(+) TGTTC(C/T)TTCAT intron-variant, nc-transcript-variant
rs1059417 -- 106,543,458(+) CAACT(A/C/G/T)TGATA nc-transcript-variant, utr-variant-3-prime
rs3783057 -- 106,544,771(-) CCTTT(G/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARGLU1 Gene

Variant ID Type Subtype PubMed ID
nsv1172 CNV Insertion 18451855

Variation tolerance for ARGLU1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARGLU1 Gene

Disorders for ARGLU1 Gene

Relevant External Links for ARGLU1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARGLU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGLU1 Gene

Publications for ARGLU1 Gene

  1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PMID: 21454576) Zhang D. … Zhang X. (J. Biol. Chem. 2011) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ARGLU1 Gene

Sources for ARGLU1 Gene