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Aliases for ARGLU1 Gene

Aliases for ARGLU1 Gene

  • Arginine And Glutamate Rich 1 2 3 5

External Ids for ARGLU1 Gene

Previous GeneCards Identifiers for ARGLU1 Gene

  • GC13M105992
  • GC13M107194
  • GC13M087787

Summaries for ARGLU1 Gene

GeneCards Summary for ARGLU1 Gene

ARGLU1 (Arginine And Glutamate Rich 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ARGLU1 Gene

  • Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Additional gene information for ARGLU1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGLU1 Gene

Genomics for ARGLU1 Gene

Regulatory Elements for ARGLU1 Gene

Enhancers for ARGLU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H106564 1.6 FANTOM5 Ensembl ENCODE 22.4 +0.2 151 6.1 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1 ETS1 ARGLU1 LINC00443 EFNB2
GH13H106561 1 Ensembl ENCODE 12.2 +6.3 6260 1.8 RB1 BACH1 EBF1 BATF RELA ZNF121 ZFHX2 POLR2A EED SCRT2 ARGLU1 EFNB2
GH13H106033 0.6 ENCODE 11.6 +534.3 534280 0.2 ZBTB49 SCRT1 CTCF GATA3 CEBPG RAD21 PRDM1 ARGLU1 RNA5SP38 ENSG00000252550
GH13H106587 0.6 ENCODE 6.5 -19.6 -19561 0.8 ELF3 SOX5 SOX13 FOXA2 SAP130 SP5 FOXA3 CEBPA BCL6 ARGLU1 LOC105370348 GC13P106610
GH13H106099 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +467.4 467362 2.9 PKNOX1 KLF1 MAX KLF17 BMI1 EBF1 POLR2A PRDM10 RFX1 NR2F1 ARGLU1 RNA5SP38 ENSG00000252550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARGLU1 on UCSC Golden Path with GeneCards custom track

Promoters for ARGLU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000065521 866 2601 PKNOX1 ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1 ETS1 ZNF143 RUNX3

Genomic Locations for ARGLU1 Gene

Genomic Locations for ARGLU1 Gene
26,494 bases
Minus strand

Genomic View for ARGLU1 Gene

Genes around ARGLU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARGLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGLU1 Gene

Proteins for ARGLU1 Gene

  • Protein details for ARGLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine and glutamate-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E0Y3
    • Q5T257
    • Q6IQ34

    Protein attributes for ARGLU1 Gene

    273 amino acids
    Molecular mass:
    33216 Da
    Quaternary structure:
    • Directly interacts with MED1.
    • Sequence=CAI13166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARGLU1 Gene


neXtProt entry for ARGLU1 Gene

Post-translational modifications for ARGLU1 Gene

  • Ubiquitination at posLast=270270
  • Modification sites at PhosphoSitePlus

Other Protein References for ARGLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGLU1 Gene

Domains & Families for ARGLU1 Gene

Gene Families for ARGLU1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARGLU1 Gene


Suggested Antigen Peptide Sequences for ARGLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0430 family.
  • Belongs to the UPF0430 family.
genes like me logo Genes that share domains with ARGLU1: view

Function for ARGLU1 Gene

Molecular function for ARGLU1 Gene

UniProtKB/Swiss-Prot Function:
Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Gene Ontology (GO) - Molecular Function for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with ARGLU1: view

Phenotypes for ARGLU1 Gene

genes like me logo Genes that share phenotypes with ARGLU1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARGLU1 Gene

Localization for ARGLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGLU1 Gene

Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARGLU1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ARGLU1: view

Pathways & Interactions for ARGLU1 Gene

SuperPathways for ARGLU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARGLU1: view

No data available for Pathways by source and SIGNOR curated interactions for ARGLU1 Gene

Drugs & Compounds for ARGLU1 Gene

No Compound Related Data Available

Transcripts for ARGLU1 Gene

Unigene Clusters for ARGLU1 Gene

Arginine and glutamate rich 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP5: -

Relevant External Links for ARGLU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARGLU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARGLU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARGLU1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Spleen (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARGLU1 Gene

Protein tissue co-expression partners for ARGLU1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARGLU1 Gene:


SOURCE GeneReport for Unigene cluster for ARGLU1 Gene:


Evidence on tissue expression from TISSUES for ARGLU1 Gene

  • Liver(4.4)
  • Nervous system(4)
  • Lung(3.3)
  • Pancreas(2.2)
  • Intestine(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ARGLU1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARGLU1 Gene

Orthologs for ARGLU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARGLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARGLU1 33 34
  • 99.76 (n)
(Monodelphis domestica)
Mammalia ARGLU1 34
  • 97 (a)
(Bos Taurus)
Mammalia ARGLU1 33 34
  • 95.85 (n)
(Canis familiaris)
Mammalia ARGLU1 33 34
  • 94.63 (n)
(Mus musculus)
Mammalia Arglu1 33 16 34
  • 93.6 (n)
(Rattus norvegicus)
Mammalia Arglu1 33
  • 93.6 (n)
(Gallus gallus)
Aves ARGLU1 33 34
  • 86.15 (n)
(Anolis carolinensis)
Reptilia ARGLU1 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arglu1 33
  • 82.77 (n)
MGC76303 33
(Danio rerio)
Actinopterygii arglu1a 34
  • 82 (a)
arglu1b 33 34
  • 74.47 (n)
zgc55548 33
fruit fly
(Drosophila melanogaster)
Insecta CG31712 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8765 34
  • 52 (a)
Species where no ortholog for ARGLU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARGLU1 Gene

Gene Tree for ARGLU1 (if available)
Gene Tree for ARGLU1 (if available)

Paralogs for ARGLU1 Gene

No data available for Paralogs for ARGLU1 Gene

Variants for ARGLU1 Gene

Sequence variations from dbSNP and Humsavar for ARGLU1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000032373 -- 106,563,915(+) CTAGA(C/G)TAAGT intron-variant
rs1000134529 -- 106,559,206(+) TAAAT(A/C)AAAAA intron-variant, nc-transcript-variant
rs1000158033 -- 106,570,062(+) GGAGC(C/G)TCATT intron-variant, upstream-variant-2KB
rs1000193398 -- 106,553,272(+) TTGGA(G/T)ATATA intron-variant
rs1000209970 -- 106,552,848(+) AAATA(A/C)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARGLU1 Gene

Variant ID Type Subtype PubMed ID
nsv475169 CNV novel sequence insertion 20440878
nsv1172 CNV insertion 18451855
nsv1039628 CNV gain 25217958
esv3633468 CNV gain 21293372

Variation tolerance for ARGLU1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARGLU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARGLU1 Gene

Disorders for ARGLU1 Gene

Relevant External Links for ARGLU1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARGLU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGLU1 Gene

Publications for ARGLU1 Gene

  1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PMID: 21454576) Zhang D … Zhang X (The Journal of biological chemistry 2011) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ARGLU1 Gene

Sources for ARGLU1 Gene

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