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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARGFX Gene

protein-coding   GIFtS: 36
GCID: GC03P121286

Arginine-Fifty Homeobox

  Search for ARGFX
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arginine-Fifty Homeobox1 2

External Ids:    HGNC: 301461   Entrez Gene: 5035822   Ensembl: ENSG000001861037   OMIM: 6111645   UniProtKB: A6NJG63   

Export aliases for ARGFX gene to outside databases

Previous GC identifers: GC03U900585 GC03P122787 GC03P118660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARGFX Gene:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic
development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.
This gene is a member of the ARGFX homeobox gene family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARGFX Gene: 
ARGFX (arginine-fifty homeobox) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Function: Putative transcription factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARGFX gene promoter:
         POU3F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARGFX promoter sequence
   Search SABiosciences Chromatin IP Primers for ARGFX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGFX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

ARGFX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARGFX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121286:  view genomic region     (about GC identifiers)

Start:
121,286,778 bp from pter      End:
121,309,469 bp from pter
Size:
22,692 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6 (See protein sequence)
Recommended Name: Arginine-fifty homeobox  
Size: 315 amino acids; 35617 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ARGFX: NX_A6NJG6

Explore proteomics data for ARGFX at MOPED 

ARGFX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ARGFX Protein Expression

REFSEQ proteins: NP_001012677.1  
ENSEMBL proteins: 
 ENSP00000335578  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

ARGFX for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
PRD: Homeoboxes / PRD class

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry A6NJG6

ProtoNet protein and cluster: A6NJG6

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Similarity: Belongs to the paired homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


ARGFX for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ARGFX_HUMAN, A6NJG6
Function: Putative transcription factor (By similarity)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
ARGFX for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARGFX

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent ----

ARGFX for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARGFX gene: 
NM_001012659.1  

Unigene Cluster for ARGFX:

Arginine-fifty homeobox
Hs.224976  [show with all ESTs]
Unigene Representative Sequence: NM_001012659
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000334384(uc003eef.3)
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1 DOTS entry:

DT.65284810 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARGFX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGGATGAA
ARGFX Expression
About this image


See ARGFX Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.224976

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARGFX gene from 2/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
cow
(Bos taurus)
Mammalia ARGFX1 arginine-fifty homeobox 77.21(n)
63.09(a)
  783691  XM_003585648.1  XP_003585696.1 
worm
(Caenorhabditis elegans)
Secernentea ceh-376
ceh-366
Homeobox protein ceh-36
15(a)
15(a)
possible ortholog
possible ortholog
X(14197362-14209153)
X(14183449-14185597)


ENSEMBL Gene Tree for ARGFX (if available)
TreeFam Gene Tree for ARGFX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ARGFX gene
6 SIMAP similar genes for ARGFX using alignment to 1 protein entry:     ARGFX_HUMAN:
COQ5    PFKFB3    TUBA1C    POU6F1    CRX    HOXB1

ARGFX for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ARGFX
PGOHUM00000237025 PGOHUM00000235745


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/554 SNPs in ARGFX are shown (see all 554)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1415620831,2
--121284874(+) AAAAGC/TAACTA 1 -- us2k10--------
rs1898226231,2
--121284887(+) GAGTAC/GAGAAC 1 -- us2k10--------
rs31013451,2
C,F,A,H--121285031(+) TTACAA/GTTAAA 1 -- us2k117Minor allele frequency- G:0.13NS EA NA WA CSA 894
rs1817862991,2
--121285043(+) GAACTA/GTTTTT 1 -- us2k10--------
rs1470518931,2
C--121285117(+) TCAAAA/G/TTACTT 1 -- us2k10--------
rs2007578331,2
--121285120(+) AGTAC-/TTTGAT 1 -- us2k10--------
rs1481145141,2
--121285134(+) CATATA/GGTTAA 1 -- us2k10--------
rs1419165421,2
C--121285409(+) TCATTC/TTAGCC 1 -- us2k10--------
rs5107091,2
C,F,H--121285493(+) tctaaA/Ccaaag 1 -- us2k17Minor allele frequency- C:0.09NS EA NA 698
rs1869553461,2
--121285538(+) TGCATA/GTAACT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ARGFX (121286778 - 121309469 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ARGFX:    About this table     
Variant IDTypeSubtypePubMed ID
esv33473CNV Loss17666407
nsv877381CNV Gain21882294
nsv877382CNV Gain21882294
dgv1489e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARGFX for disorders           About MalaCards
OMIM gene information: 611164    OMIM disorders: --


ARGFX for disorders           About GeneDecksing


Export disorders for ARGFX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ARGFX gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARGFX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1, 2 Booth H.A. and Holland P.W.H. (2007)
  2. The origin and evolution of ARGFX homeobox loci in ma mmalian radiation. (PubMed id 20565723)1 Li G. and Holland P.W. (2010)
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 503582 HGNC: 30146 Ensembl:ENSG00000186103 euGenes: HUgn503582 ECgene: ARGFX
H-InvDB: ARGFX

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ARGFX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ARGFX gene:
Search GeneIP for patents involving ARGFX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 SwitchGear Promoter luciferase reporter plasmids for ARGFX
 Search ThermoFisher Antibodies for ARGFX
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARGFX
 inGenious Targeting Laboratory - Custom generated mouse model solutions for ARGFX
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARGFX
Customized:
 lentivirus for stable overexpression of ARGFX
 lentivirus expression plasmids for stable overexpression of ARGFX
 adenovirus for overexpression of ARGFX
 LSBio Antibodies in human, mouse, rat for ARGFX
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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