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ARGFX Gene

protein-coding   GIFtS: 36
GCID: GC03P121286

Arginine-Fifty Homeobox

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginine-Fifty Homeobox1 2

External Ids:    HGNC: 301461   Entrez Gene: 5035822   Ensembl: ENSG000001861037   OMIM: 6111645   UniProtKB: A6NJG63   

Export aliases for ARGFX gene to outside databases

Previous GC identifers: GC03U900585 GC03P122787 GC03P118660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARGFX Gene:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic
development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.
This gene is a member of the ARGFX homeobox gene family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARGFX Gene:
ARGFX (arginine-fifty homeobox) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Function: Putative transcription factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARGFX gene promoter:
         POU3F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARGFX promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARGFX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

ARGFX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARGFX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121286:  view genomic region     (about GC identifiers)

Start:
121,286,778 bp from pter      End:
121,309,469 bp from pter
Size:
22,692 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6 (See protein sequence)
Recommended Name: Arginine-fifty homeobox  
Size: 315 amino acids; 35617 Da

Explore the universe of human proteins at neXtProt for ARGFX: NX_A6NJG6

Explore proteomics data for ARGFX at MOPED


See ARGFX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001012677.1  
ENSEMBL proteins: 
 ENSP00000335578  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry A6NJG6

ProtoNet protein and cluster: A6NJG6

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Similarity: Belongs to the paired homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with ARGFX           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ARGFX_HUMAN, A6NJG6
Function: Putative transcription factor (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with ARGFX           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ARGFX_HUMAN, A6NJG6: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ARGFX

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----

Find genes that share ontologies with ARGFX           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ARGFX gene: 
NM_001012659.1  

Unigene Cluster for ARGFX:

Arginine-fifty homeobox
Hs.224976  [show with all ESTs]
Unigene Representative Sequence: NM_001012659
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000334384(uc003eef.3)
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1 DOTS entry:

DT.65284810 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ARGFX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGGATGAA
ARGFX Expression
About this image

ARGFX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ARGFX Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.224976

UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6
Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ARGFX gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
cow
(Bos taurus)
Mammalia ARGFX1 arginine-fifty homeobox 77.07(n)
62.66(a)
  783691  XM_003585648.2  XP_003585696.2 


ENSEMBL Gene Tree for ARGFX (if available)
TreeFam Gene Tree for ARGFX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ARGFX gene
6 SIMAP similar genes for ARGFX using alignment to 1 protein entry:     ARGFX_HUMAN:
COQ5    PFKFB3    TUBA1C    POU6F1    CRX    HOXB1

Find genes that share paralogs with ARGFX           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for ARGFX
PGOHUM00000237025 PGOHUM00000235745


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ARGFX (see all 554)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1415620831,2
--121284874(+) AAAAGC/TAACTA 1 -- us2k10--------
rs1898226231,2
--121284887(+) GAGTAC/GAGAAC 1 -- us2k10--------
rs31013451,2
C,F,A,H--121285031(+) TTACAA/GTTAAA 1 -- us2k117Minor allele frequency- G:0.13NS EA NA WA CSA 894
rs1817862991,2
--121285043(+) GAACTA/GTTTTT 1 -- us2k10--------
rs1470518931,2
C--121285117(+) TCAAAA/G/TTACTT 1 -- us2k10--------
rs2007578331,2
--121285120(+) AGTAC-/TTTGAT 1 -- us2k10--------
rs1481145141,2
--121285134(+) CATATA/GGTTAA 1 -- us2k10--------
rs1419165421,2
C--121285409(+) TCATTC/TTAGCC 1 -- us2k10--------
rs5107091,2
C,F,H--121285493(+) tctaaA/Ccaaag 1 -- us2k17Minor allele frequency- C:0.09NS EA NA 698
rs1869553461,2
--121285538(+) TGCATA/GTAACT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ARGFX (121286778 - 121309469 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ARGFX:    About this table    
Variant IDTypeSubtypePubMed ID
esv33473CNV Loss17666407
nsv877381CNV Gain21882294
nsv877382CNV Gain21882294
dgv1489e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611164    OMIM disorders: --


Find genes that share disorders with ARGFX           About GenesLikeMe


Export disorders for ARGFX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ARGFX gene integrated from 10 sources:
(articles sorted by number of sources associating them with ARGFX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1, 2 Booth H.A. and Holland P.W.H. (Gene 2007)
  2. The origin and evolution of ARGFX homeobox loci in mammalian radiation. (PubMed id 20565723)1 Li G. and Holland P.W. (BMC Evol. Biol. 2010)
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 503582 HGNC: 30146 Ensembl:ENSG00000186103 euGenes: HUgn503582 ECgene: ARGFX
H-InvDB: ARGFX

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ARGFX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ARGFX gene:
Search GeneIP for patents involving ARGFX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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