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Aliases for ARGFX Gene

Aliases for ARGFX Gene

  • Arginine-Fifty Homeobox 2 3

External Ids for ARGFX Gene

Previous GeneCards Identifiers for ARGFX Gene

  • GC03U900585
  • GC03P122787
  • GC03P121286
  • GC03P118660

Summaries for ARGFX Gene

Entrez Gene Summary for ARGFX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARGFX Gene

ARGFX (Arginine-Fifty Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ARGFX Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGFX Gene

Genomics for ARGFX Gene

Regulatory Elements for ARGFX Gene

Transcription factor binding sites by QIAGEN in the ARGFX gene promoter:

Genomic Location for ARGFX Gene

Start:
121,562,422 bp from pter
End:
121,590,622 bp from pter
Size:
28,201 bases
Orientation:
Plus strand

Genomic View for ARGFX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARGFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGFX Gene

Proteins for ARGFX Gene

  • Protein details for ARGFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJG6-ARGFX_HUMAN
    Recommended name:
    Arginine-fifty homeobox
    Protein Accession:
    A6NJG6
    Secondary Accessions:

    Protein attributes for ARGFX Gene

    Size:
    315 amino acids
    Molecular mass:
    35617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARGFX Gene

Proteomics data for ARGFX Gene at MOPED

Post-translational modifications for ARGFX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARGFX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGFX Gene

Domains for ARGFX Gene

Gene Families for ARGFX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for ARGFX Gene

Suggested Antigen Peptide Sequences for ARGFX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJG6

UniProtKB/Swiss-Prot:

ARGFX_HUMAN :
  • A6NJG6
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with ARGFX: view

Function for ARGFX Gene

Molecular function for ARGFX Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor.

Gene Ontology (GO) - Molecular Function for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ARGFX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARGFX Gene

Localization for ARGFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGFX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARGFX Gene COMPARTMENTS Subcellular localization image for ARGFX gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ARGFX: view

Pathways for ARGFX Gene

SuperPathways for ARGFX Gene

No Data Available

Interacting Proteins for ARGFX Gene

Gene Ontology (GO) - Biological Process for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARGFX: view

No data available for Pathways by source for ARGFX Gene

Transcripts for ARGFX Gene

mRNA/cDNA for ARGFX Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARGFX Gene

Arginine-fifty homeobox:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARGFX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARGFX
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARGFX Gene

No ASD Table

Relevant External Links for ARGFX Gene

GeneLoc Exon Structure for
ARGFX
ECgene alternative splicing isoforms for
ARGFX

Expression for ARGFX Gene

mRNA expression in normal human tissues for ARGFX Gene

mRNA differential expression in normal tissues according to GTEx for ARGFX Gene

This gene is overexpressed in Testis (26.1) and Heart - Left Ventricle (4.6).

SOURCE GeneReport for Unigene cluster for ARGFX Gene Hs.224976

mRNA Expression by UniProt/SwissProt for ARGFX Gene

A6NJG6-ARGFX_HUMAN
Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells.
genes like me logo Genes that share expressions with ARGFX: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ARGFX Gene

Orthologs for ARGFX Gene

This gene was present in the common ancestor of mammals.

Orthologs for ARGFX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARGFX 35
  • 99.04 (n)
  • 97.77 (a)
ARGFX 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARGFX 35
  • 77.07 (n)
  • 62.66 (a)
ARGFX 36
  • 61 (a)
OneToOne
Species with no ortholog for ARGFX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARGFX Gene

ENSEMBL:
Gene Tree for ARGFX (if available)
TreeFam:
Gene Tree for ARGFX (if available)

Paralogs for ARGFX Gene

Selected SIMAP similar genes for ARGFX Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARGFX Gene

genes like me logo Genes that share paralogs with ARGFX: view

No data available for Paralogs for ARGFX Gene

Variants for ARGFX Gene

Sequence variations from dbSNP and Humsavar for ARGFX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs479108 -- 121,565,555(+) CAAAG(C/T)GCACA intron-variant
rs483713 -- 121,580,077(+) cctcc(C/T)gagta intron-variant
rs485275 -- 121,571,819(+) cctTT(A/G)GGGtt intron-variant
rs486813 -- 121,585,863(+) TCCTA(C/T)TGACT intron-variant
rs499355 -- 121,561,804(+) CTGCC(A/T)AAGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARGFX Gene

Variant ID Type Subtype PubMed ID
nsv877381 CNV Gain 21882294
dgv1489e1 CNV Complex 17122850
esv33473 CNV Loss 17666407
nsv877382 CNV Gain 21882294

Relevant External Links for ARGFX Gene

HapMap Linkage Disequilibrium report
ARGFX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARGFX Gene

Disorders for ARGFX Gene

No disorders were found for ARGFX Gene.

No data available for UniProtKB/Swiss-Prot for ARGFX Gene

Publications for ARGFX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 4
  2. The origin and evolution of ARGFX homeobox loci in mammalian radiation. (PMID: 20565723) Li G. … Holland P.W. (BMC Evol. Biol. 2010) 3
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for ARGFX Gene

Sources for ARGFX Gene

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