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Aliases for ARGFX Gene

Aliases for ARGFX Gene

  • Arginine-Fifty Homeobox 2 3 5

External Ids for ARGFX Gene

Previous GeneCards Identifiers for ARGFX Gene

  • GC03U900585
  • GC03P122787
  • GC03P121286
  • GC03P118660

Summaries for ARGFX Gene

Entrez Gene Summary for ARGFX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARGFX Gene

ARGFX (Arginine-Fifty Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ARGFX Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGFX Gene

Genomics for ARGFX Gene

Regulatory Elements for ARGFX Gene

Enhancers for ARGFX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARGFX on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ARGFX gene promoter:

Genomic Location for ARGFX Gene

121,562,303 bp from pter
121,590,622 bp from pter
28,320 bases
Plus strand

Genomic View for ARGFX Gene

Genes around ARGFX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARGFX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARGFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGFX Gene

Proteins for ARGFX Gene

  • Protein details for ARGFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine-fifty homeobox
    Protein Accession:

    Protein attributes for ARGFX Gene

    315 amino acids
    Molecular mass:
    35617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARGFX Gene

Proteomics data for ARGFX Gene at MOPED

Post-translational modifications for ARGFX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARGFX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGFX Gene

Domains & Families for ARGFX Gene

Gene Families for ARGFX Gene

Protein Domains for ARGFX Gene

Suggested Antigen Peptide Sequences for ARGFX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with ARGFX: view

Function for ARGFX Gene

Molecular function for ARGFX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Phenotypes for ARGFX Gene

genes like me logo Genes that share phenotypes with ARGFX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARGFX Gene

Localization for ARGFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGFX Gene

Subcellular locations from

Jensen Localization Image for ARGFX Gene COMPARTMENTS Subcellular localization image for ARGFX gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ARGFX Gene

Pathways & Interactions for ARGFX Gene

SuperPathways for ARGFX Gene

No Data Available

Interacting Proteins for ARGFX Gene

Gene Ontology (GO) - Biological Process for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARGFX: view

No data available for Pathways by source and SIGNOR curated interactions for ARGFX Gene

Drugs & Compounds for ARGFX Gene

No Compound Related Data Available

Transcripts for ARGFX Gene

mRNA/cDNA for ARGFX Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARGFX Gene

Arginine-fifty homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARGFX Gene

No ASD Table

Relevant External Links for ARGFX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARGFX Gene

mRNA expression in normal human tissues for ARGFX Gene

mRNA differential expression in normal tissues according to GTEx for ARGFX Gene

This gene is overexpressed in Testis (x26.1) and Heart - Left Ventricle (x4.6).

SOURCE GeneReport for Unigene cluster for ARGFX Gene Hs.224976

mRNA Expression by UniProt/SwissProt for ARGFX Gene

Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells.
genes like me logo Genes that share expression patterns with ARGFX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ARGFX Gene

Orthologs for ARGFX Gene

This gene was present in the common ancestor of mammals.

Orthologs for ARGFX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARGFX 35
  • 77.07 (n)
  • 62.66 (a)
  • 61 (a)
(Pan troglodytes)
Mammalia ARGFX 35
  • 99.04 (n)
  • 97.77 (a)
  • 97 (a)
Species with no ortholog for ARGFX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARGFX Gene

Gene Tree for ARGFX (if available)
Gene Tree for ARGFX (if available)

Paralogs for ARGFX Gene

(6) SIMAP similar genes for ARGFX Gene using alignment to 1 proteins: Pseudogenes for ARGFX Gene

genes like me logo Genes that share paralogs with ARGFX: view

No data available for Paralogs for ARGFX Gene

Variants for ARGFX Gene

Sequence variations from dbSNP and Humsavar for ARGFX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_037226 -
rs479108 -- 121,565,555(+) CAAAG(C/T)GCACA intron-variant
rs499355 -- 121,561,804(+) CTGCC(A/T)AAGTT upstream-variant-2KB
rs510709 -- 121,566,646(+) tctaa(A/C)caaag intron-variant, upstream-variant-2KB
rs616966 -- 121,561,944(+) ATAAG(A/G)AAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARGFX Gene

Variant ID Type Subtype PubMed ID
nsv877381 CNV Gain 21882294
dgv1489e1 CNV Complex 17122850
esv33473 CNV Loss 17666407
nsv877382 CNV Gain 21882294

Variation tolerance for ARGFX Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARGFX Gene

Disorders for ARGFX Gene

Relevant External Links for ARGFX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARGFX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGFX Gene

Publications for ARGFX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 2 3 4 67
  2. The origin and evolution of ARGFX homeobox loci in mammalian radiation. (PMID: 20565723) Li G. … Holland P.W. (BMC Evol. Biol. 2010) 2 3

Products for ARGFX Gene

Sources for ARGFX Gene