ARGFX Gene
protein-coding GIFtS: 37
GCID: GC03P121286
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arginine-fifty homeobox
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Aliases
for ARGFX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arginine-Fifty Homeobox1 2 |
Export aliases for ARGFX gene to outside databasesPrevious GC identifers: GC03U900585 GC03P122787 GC03P118660 |
Summaries
for ARGFX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARGFX:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development.Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is amember of the ARGFX homeobox gene family. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6Function: Putative transcription factor (By similarity)
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Genomic Views
for ARGFX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARGFX gene promoter:
POU3F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARGFX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGFX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.33ARGFX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P121286: view genomic region
(about GC identifiers)
Start:
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121,286,778 bp from pter |
End:
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121,309,469 bp from pter |
Size:
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22,692 bases |
Orientation:
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plus strand |
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Proteins
for ARGFX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6 (See
protein sequence)Recommended Name: Arginine-fifty homeobox Size: 315 amino acids; 35617 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for ARGFX: NX_A6NJG6
ARGFX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012677.1
ENSEMBL proteins: ENSP00000335578
Human Recombinant Protein Products for ARGFX:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ARGFX for ontologies About GeneDecksing
ARGFX Antibody Products:
Assay Products for ARGFX: |
Protein
Domains /
Families
for ARGFX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARGFX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJG6ProtoNet protein and cluster: A6NJG6 UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6Similarity: Belongs to the paired homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for ARGFX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ARGFX_HUMAN, A6NJG6Function: Putative transcription factor (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
ARGFX for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARGFX (NM_001012659) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARGFX | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARGFX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGFX |
|
Pathways & Interactions
for ARGFX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARGFX
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
ARGFX for ontologies About GeneDecksing
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Drugs & Compounds
for ARGFX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARGFX
Search CenterWatch for drugs/clinical trials and news about ARGFX
|
Transcripts
for ARGFX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARGFX gene: NM_001012659.1 Unigene Cluster for ARGFX: Arginine-fifty homeobox Hs.224976 [show with all ESTs]Unigene Representative Sequence: NM_0010126591 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000334384(uc003eef.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARGFX (NM_001012659) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARGFX | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARGFX |
1 DOTS entry: DT.65284810
GeneLoc Exon Structure
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Expression
for ARGFX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARGFX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGATGAA
About this image
See ARGFX Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.224976
UniProtKB/Swiss-Prot: ARGFX_HUMAN, A6NJG6Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells
SABiosciences Custom PCR Arrays for ARGFX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARGFX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARGFX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGFX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGFX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGFX |
Orthologs
for ARGFX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARGFX gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for ARGFX (if available)
TreeFam Gene Tree for ARGFX (if available) |
Paralogs
for ARGFX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARGFX gene
- GSC2 OTX22 HESX12 PROP12 DMBX12 GSC22 SEBOX2 MIXL12
- OTX12 CRX2
7 SIMAP similar genes for ARGFX using alignment to 1 protein entry: ARGFX_HUMAN:COQ5 NCKAP1L PFKFB3 TUBA1C POU6F1 CRX
HOXB1
ARGFX for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ARGFX
PGOHUM00000237025 PGOHUM00000235745
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Genomic Variants
for ARGFX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARGFX (121286778 - 121309469 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARGFX
2 CNVs: 7356 2469 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARGFX |
|
Disorders
/ Diseases
for ARGFX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARGFX for disorders About GeneDecksing
OMIM gene information: 611164
OMIM disorders: --
1  disease for ARGFX: About MalaCardsneuronitis
Export disorders for ARGFX gene to outside databases
|
Publications
for ARGFX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARGFX gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARGFX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1, 2 Booth H.A. and Holland P.W.H. (2007)
- The origin and evolution of ARGFX homeobox loci in ma mmalian radiation. (PubMed id 20565723)1 Li G. and Holland P.W. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
|
External Searches for ARGFX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ARGFX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARGFX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARGFX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARGFX | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ARGFX gene:
Search GeneIP for patents involving ARGFX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARGFX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARGFX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARGFX | | | OriGene Protein Over-expression Lysate for ARGFX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARGFX | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARGFX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARGFX | | OriGene Custom Protein Services for ARGFX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARGFX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARGFX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARGFX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARGFX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARGFX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARGFX |
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 |  |  |  | |
| | | | Search Tocris compounds for ARGFX |
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 | | | ARGFX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARGFX |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ARGFX |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARGFX |
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