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Aliases for ARG2 Gene

Aliases for ARG2 Gene

  • Arginase 2 2 3
  • EC 3.5.3.1 4 63
  • Kidney-Type Arginase 4
  • Non-Hepatic Arginase 4
  • Arginase, Type II 2
  • Type II Arginase 4
  • EC 3.5.3 63

External Ids for ARG2 Gene

Previous GeneCards Identifiers for ARG2 Gene

  • GC14P065591
  • GC14P061880
  • GC14P066076
  • GC14P067156
  • GC14P068086
  • GC14P048256

Summaries for ARG2 Gene

Entrez Gene Summary for ARG2 Gene

  • Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARG2 Gene

ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include argininemia and impotence. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include arginase activity. An important paralog of this gene is ARG1.

UniProtKB/Swiss-Prot for ARG2 Gene

  • May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARG2 Gene

Genomics for ARG2 Gene

Regulatory Elements for ARG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARG2 Gene

Chromosome:
14
Start:
67,619,798 bp from pter
End:
67,651,720 bp from pter
Size:
31,923 bases
Orientation:
Plus strand

Genomic View for ARG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARG2 Gene

Proteins for ARG2 Gene

  • Protein details for ARG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78540-ARGI2_HUMAN
    Recommended name:
    Arginase-2, mitochondrial
    Protein Accession:
    P78540
    Secondary Accessions:
    • B2R690
    • Q6FHY8

    Protein attributes for ARG2 Gene

    Size:
    354 amino acids
    Molecular mass:
    38578 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for ARG2 Gene

neXtProt entry for ARG2 Gene

Proteomics data for ARG2 Gene at MOPED

Post-translational modifications for ARG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ARG2 Gene

Gene Families for ARG2 Gene

IUPHAR :

Suggested Antigen Peptide Sequences for ARG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78540

UniProtKB/Swiss-Prot:

ARGI2_HUMAN :
  • Belongs to the arginase family.
Family:
  • Belongs to the arginase family.
genes like me logo Genes that share domains with ARG2: view

Function for ARG2 Gene

Molecular function for ARG2 Gene

GENATLAS Biochemistry:
arginase 2,expressed in extra hepatic tissues,putatively involved in nitric oxide synthesis
UniProtKB/Swiss-Prot CatalyticActivity:
L-arginine + H(2)O = L-ornithine + urea
UniProtKB/Swiss-Prot Function:
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

Enzyme Numbers (IUBMB) for ARG2 Gene

Gene Ontology (GO) - Molecular Function for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004053 arginase activity IMP 16128822
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARG2: view

Phenotypes for ARG2 Gene

genes like me logo Genes that share phenotypes with ARG2: view

Animal Models for ARG2 Gene

MGI Knock Outs for ARG2:

miRNA for ARG2 Gene

miRTarBase miRNAs that target ARG2

No data available for Transcription Factor Targets and HOMER Transcription for ARG2 Gene

Localization for ARG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARG2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARG2 Gene COMPARTMENTS Subcellular localization image for ARG2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
chloroplast 1
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 8898077
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ARG2: view

Pathways & Interactions for ARG2 Gene

genes like me logo Genes that share pathways with ARG2: view

PCR Array Products

UniProtKB/Swiss-Prot P78540-ARGI2_HUMAN

  • Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1

Gene Ontology (GO) - Biological Process for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
GO:0001657 ureteric bud development IEA --
GO:0006525 arginine metabolic process IEA --
GO:0006595 polyamine metabolic process TAS --
GO:0006809 nitric oxide biosynthetic process TAS 8898077
genes like me logo Genes that share ontologies with ARG2: view

No data available for SIGNOR curated interactions for ARG2 Gene

Drugs & Compounds for ARG2 Gene

(9) Drugs for ARG2 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist, Target 31
L-Arginine Approved Nutra Full agonist, Agonist, Target 0
Nitric Oxide Approved Pharma 540
S-2-(Boronoethyl)-L-Cysteine Experimental Pharma Target 0
Urea Experimental Pharma 0

(4) Additional Compounds for ARG2 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
glutamate
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with ARG2: view

Transcripts for ARG2 Gene

mRNA/cDNA for ARG2 Gene

Unigene Clusters for ARG2 Gene

Arginase, type II:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARG2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for ARG2 Gene

GeneLoc Exon Structure for
ARG2
ECgene alternative splicing isoforms for
ARG2

Expression for ARG2 Gene

mRNA expression in normal human tissues for ARG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARG2 Gene

This gene is overexpressed in Kidney - Cortex (x7.0), Pituitary (x4.6), and Prostate (x4.0).

Protein differential expression in normal tissues from HIPED for ARG2 Gene

This gene is overexpressed in Prostate (38.8), Islet of Langerhans (18.2), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARG2 Gene



SOURCE GeneReport for Unigene cluster for ARG2 Gene Hs.226007

mRNA Expression by UniProt/SwissProt for ARG2 Gene

P78540-ARGI2_HUMAN
Tissue specificity: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas
genes like me logo Genes that share expression patterns with ARG2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ARG2 Gene

Orthologs for ARG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARG2 35
  • 90.11 (n)
  • 92.63 (a)
ARG2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARG2 35
  • 91.89 (n)
  • 94.13 (a)
ARG2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arg2 35
  • 85.88 (n)
  • 84.75 (a)
Arg2 16
Arg2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARG2 35
  • 99.62 (n)
  • 100 (a)
ARG2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arg2 35
  • 84.93 (n)
  • 83.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARG2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARG2 35
  • 74.2 (n)
  • 74.58 (a)
ARG2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARG2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arg2 35
  • 70.9 (n)
  • 72.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53991 35
zebrafish
(Danio rerio)
Actinopterygii arg2 35
  • 62.6 (n)
  • 62.5 (a)
wufb67g02 35
arg2 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008783 35
  • 48.87 (n)
  • 42.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta arg 35
  • 47.24 (n)
  • 42.72 (a)
arg 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8475 36
  • 48 (a)
OneToMany
Species with no ortholog for ARG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARG2 Gene

ENSEMBL:
Gene Tree for ARG2 (if available)
TreeFam:
Gene Tree for ARG2 (if available)

Paralogs for ARG2 Gene

Paralogs for ARG2 Gene

(1) SIMAP similar genes for ARG2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARG2 Gene

genes like me logo Genes that share paralogs with ARG2: view

Variants for ARG2 Gene

Sequence variations from dbSNP and Humsavar for ARG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs182074730 -- 67,624,061(+) GTCCC(A/G)AACTC intron-variant
rs182063866 -- 67,622,495(+) AAGGC(C/G)TCTCT intron-variant
rs182063235 -- 67,644,474(+) CCAGT(A/G)TGGGA intron-variant
rs182002762 -- 67,626,472(+) GCAAA(C/T)CCATT intron-variant
rs181585533 -- 67,637,649(+) AGTGG(A/G)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARG2 Gene

Variant ID Type Subtype PubMed ID
nsv456331 CNV Gain 19166990
nsv470651 CNV Gain 18288195
nsv902066 CNV Gain 21882294
nsv902068 CNV Gain 21882294

Variation tolerance for ARG2 Gene

Residual Variation Intolerance Score: 73.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARG2 Gene

HapMap Linkage Disequilibrium report
ARG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARG2 Gene

Disorders for ARG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARG2 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
argininemia
  • hyperargininemia
impotence
  • sexual impotence
- elite association
Search ARG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARG2

Genetic Association Database (GAD)
ARG2
Human Genome Epidemiology (HuGE) Navigator
ARG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARG2
genes like me logo Genes that share disorders with ARG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARG2 Gene

Publications for ARG2 Gene

  1. L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. (PMID: 12874210) Rodriguez P.C. … Ochoa A.C. (J. Immunol. 2003) 23 25 26 67
  2. Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. (PMID: 16801455) Topal G. … David-Dufilho M. (J. Pharmacol. Exp. Ther. 2006) 23 25 67
  3. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. (PMID: 8898077) Gotoh T. … Mori M. (FEBS Lett. 1996) 2 23 67
  4. Cloning and characterization of the human type II arginase gene. (PMID: 8954792) Vockley J.G. … Cederbaum S.D. (Genomics 1996) 2 23 67
  5. Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts. (PMID: 20107769) Warnken M. … RackAc K. (Naunyn Schmiedebergs Arch. Pharmacol. 2010) 23 67

Products for ARG2 Gene

Sources for ARG2 Gene

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