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ARG2 Gene

protein-coding   GIFtS: 67
GCID: GC14P068086

Arginase 2

(Previous names: arginase, type II)
  See ARG2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginase 21 2     Arginase-2, Mitochondrial2
Arginase, Type II1 2     Kidney Arginase2
Kidney-Type Arginase2 3     L-Arginine Amidinohydrolase2
Non-Hepatic Arginase2 3     L-Arginine Ureahydrolase2
Type II Arginase2 3     Nonhepatic Arginase2
EC 3.5.3.13 8     EC 3.5.38

External Ids:    HGNC: 6641   Entrez Gene: 3842   Ensembl: ENSG000000811817   OMIM: 1078305   UniProtKB: P785403   

Export aliases for ARG2 gene to outside databases

Previous GC identifers: GC14P065591 GC14P061880 GC14P066076 GC14P067156 GC14P048256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARG2 Gene:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase
exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic
crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the
mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is
poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of
the type II gene resulting from the use of alternative polyadenylation sites have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ARG2 Gene:
ARG2 (arginase 2) is a protein-coding gene. Diseases associated with ARG2 include hyperargininemia. An important paralog of this gene is AGMAT.

UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of
nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase.
Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the
vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for
the treatment of male and female sexual arousal disorders




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARG2 gene promoter:
         HOXA9B   HOXA9   NCX/Ncx   Pax-2   Pax-2a   RORalpha2   Pax-2b   STAT3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARG2 promoter sequence
   Search Chromatin IP Primers for ARG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

ARG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P068086:  view genomic region     (about GC identifiers)

Start:
68,086,515 bp from pter      End:
68,118,437 bp from pter
Size:
31,923 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540 (See protein sequence)
Recommended Name: Arginase-2, mitochondrial precursor  
Size: 354 amino acids; 38578 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Homotrimer
Selected PDB 3D structures from and Proteopedia for ARG2 (see all 7):
1PQ3 (3D)        4HZE (3D)        4I06 (3D)        4IE2 (3D)        4IE3 (3D)        4IXU (3D)    
Secondary accessions: B2R690 Q6FHY8

Explore the universe of human proteins at neXtProt for ARG2: NX_P78540

Explore proteomics data for ARG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ARG2 (P78540) (see all 12)
     FGQTREG  HGPAAIR  GGDHSLA  DLVEVNP 


    See ARG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001163.1  
    ENSEMBL proteins: 
     ENSP00000261783  
    Reactome Protein details: P78540

    ARG2 Human Recombinant Protein Products:

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    antibodies-online proteins for ARG2 (26 products) 

     
    antibodies-online peptides for ARG2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Arginase II
    Arginase

    4 InterPro protein domains:
     IPR014033 Arginase
     IPR006035 Ureohydrolase
     IPR023696 Ureohydrolase_domain
     IPR020855 Ureohydrolase_Mn_BS

    Graphical View of Domain Structure for InterPro Entry P78540

    ProtoNet protein and cluster: P78540

    2 Blocks protein domains:
    IPB005924 Arginase signature
    IPB006035 Arginase/agmatinase/formiminoglutamase


    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Similarity: Belongs to the arginase family


    Find genes that share domains with ARG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARGI2_HUMAN, P78540
    Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of
    nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase.
    Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the
    vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for
    the treatment of male and female sexual arousal disorders
    Catalytic activity: L-arginine + H(2)O = L-ornithine + urea

         Genatlas biochemistry entry for ARG2:
    arginase 2,expressed in extra hepatic tissues,putatively involved in nitric oxide synthesis

         Enzyme Numbers (IUBMB): EC 3.5.3.11 2 EC 3.5.32

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004053arginase activity EXP--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ARG2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arg2):
     homeostasis/metabolism 

    Find genes that share phenotypes with ARG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arg2tm1Weo for ARG2

       genOway: Develop your customized and physiologically relevant rodent model for ARG2

    miRNA
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    miRTarBase miRNAs that target ARG2:
    hsa-mir-16-5p (MIRT032015)

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    Selected qRT-PCR Assays for microRNAs that regulate ARG2 (see all 9):
    hsa-miR-875-3p hsa-miR-3673 hsa-miR-206 hsa-miR-3611 hsa-miR-1 hsa-miR-1257 hsa-miR-1252 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidARG2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARGI2_HUMAN, P78540: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS8898077
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with ARG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Arginine and proline metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups0.00
    superpathway of citrulline metabolism0.00
    arginine degradation VI (arginase 2 pathway)0.00
    arginine degradation I (arginase pathway)0.00
    citrulline biosynthesis0.00
    2Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    urea cycle0.00
    Urea cycle0.00
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Carbon metabolism
    Biosynthesis of amino acids0.38
    5Amoebiasis
    Amoebiasis


    Find genes that share SuperPaths with ARG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for ARG2 (see all 6)
        arginine degradation I (arginase pathway)
    citrulline biosynthesis
    Urea cycle and metabolism of amino groups
    superpathway of citrulline metabolism
    arginine degradation VI (arginase 2 pathway)


    1 Reactome Pathway for ARG2
        Urea cycle


    4 Kegg Pathways  (Kegg details for ARG2):
        Arginine and proline metabolism
    Metabolic pathways
    Biosynthesis of amino acids
    Amoebiasis

    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARG2: 

              Hypertension in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ARG2 (P785403 ENSP000002617834) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARG1P050893, ENSP000003570664I2D: score=1 STRING: ENSP00000357066
    ADCENSP000002945174STRING: ENSP00000294517
    ASLENSP000003071884STRING: ENSP00000307188
    NOS1ENSP000003207584STRING: ENSP00000320758
    NOS2ENSP000003272514STRING: ENSP00000327251
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000050urea cycle TAS--
    GO:0001657ureteric bud development IEA--
    GO:0006525arginine metabolic process IEA--
    GO:0006809nitric oxide biosynthetic process TAS8898077
    GO:0006941striated muscle contraction IEA--

    Find genes that share ontologies with ARG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ARG2
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARG2 (ARGI2)

    5 HMDB Compounds for ARG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    Manganesemanganese 7439-96-5--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    UreaCarbonyl diamine (see all 90)57-13-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for ARG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--15548540 12874210 14871882 15753084 15539552
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--16801455 16979358
    S-2-(Boronoethyl)-L-Cysteine-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ARG2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-2-(boronoethyl)-l-cysteine 94.6 5 11478904 (2), 17008605 (1)
    2(s)-amino-6-boronohexanoic acid 87.4 3 11478904 (2)
    ornithine 83.5 18 11370664 (2), 9131018 (2), 9874001 (1), 19000307 (1) (see all 15)
    arginine 78.8 44 18817562 (6), 11370664 (3), 9131018 (2), 19545540 (2) (see all 21)
    urea 71.8 21 11370664 (2), 17680661 (2), 9131018 (1), 19545540 (1) (see all 10)
    nitric oxide 64.1 21 8898077 (2), 11370664 (1), 12415579 (1), 16801455 (1) (see all 14)
    proline 48.4 3 11370664 (1), 20107769 (1), 8954792 (1)
    manganese 31.2 2 16128822 (2)
    oxygen 0 1 18309100 (1)
    glutamate 0 1 11370664 (1)



    Find genes that share compounds with ARG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARG2 gene: 
    NM_001172.3  

    Unigene Cluster for ARG2:

    Arginase, type II
    Hs.226007  [show with all ESTs]
    Unigene Representative Sequence: BC029050
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261783(uc001xjs.3) ENST00000557120 ENST00000556491 ENST00000557319

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    Additional mRNA sequence: 

    AK312484.1 AY074489.1 BC001350.1 BC008464.1 BC029050.1 CR536550.1 D86724.1 U75667.1 
    U82256.1 

    18 DOTS entries:

    DT.86845723  DT.97772353  DT.100786613  DT.40116859  DT.80100028  DT.91936909  DT.99995824  DT.318788 
    DT.100786614  DT.100798309  DT.120767699  DT.120767834  DT.120767693  DT.92055345  DT.92055625  DT.95170341 
    DT.99959305  DT.92046439 

    Selected AceView cDNA sequences (see all 155):

    AY074489 T08456 BQ636750 CB131607 CR536550 AI282597 D86724 F15256 
    AA506721 BG826499 BG394222 AA652284 F12274 BI821051 CR595402 CA389807 
    AA082991 CR625558 CR595481 BC008464 CR598558 BM853072 AA593627 CA841138 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARG2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                            -                           
    SP2:                                                                        
    SP3:                                -                                       
    SP4:                                                                        


    ECgene alternative splicing isoforms for ARG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCACAACA
    ARG2 Expression
    About this image


    ARG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Lung (Respiratory System)
             Mature airway epithelial cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    ARG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226007

    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Tissue specificity: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal
    muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart
    and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARG2: 
              Hypertension in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARG2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arg21 , 5 arginase type II1, 5 85.88(n)1
    84.75(a)1
      12 (35.51 cM)5
    118471  NM_009705.31  NP_033835.11 
     791307775 
    chicken
    (Gallus gallus)
    Aves ARG21 arginase, type II 74.2(n)
    74.58(a)
      423272  NM_001199704.1  NP_001186633.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARG26
    arginase 2
    73(a)
    1 ↔ 1
    GL343272.1(989386-1005932)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC539912 similar to arginase 75.42(n)    U08406.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb67g022 wufb67g02 70.02(n)   322614  BC056711.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta arg1 arginase 47.24(n)
    42.72(a)
      46717  NM_080136.2  NP_524875.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAR16
    Arginase, responsible for arginine degradation, ex...
    36(a)
    1 → many
    XVI(339944-340945) YPL111W


    ENSEMBL Gene Tree for ARG2 (if available)
    TreeFam Gene Tree for ARG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARG2 gene
    AGMAT2  ARG12  
    1 SIMAP similar gene for ARG2 using alignment to 1 protein entry:     ARGI2_HUMAN:
    ARG1

    Find genes that share paralogs with ARG2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ARG2
    PGOHUM00000243721


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARG2 (see all 715)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49025021,2
    C--48267860(+) TCTTTT/CTTTTT 1 -- int1 trp33Minor allele frequency- C:0.20WA CSA 5
    rs2006117431,2
    C--48267860(+) TCTTT-/CTTTTT 1 -- int10--------
    rs590101351,2
    C--48281429(+) AAAAA-/AA/AT 
            
    TTGAA
    1 -- int10--------
    rs1918171611,2
    --49070645(+) TATTTC/TTAGGA 1 -- us2k10--------
    rs37597611,2
    C,F--49070649(+) TTTAGG/TAGAGA 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs171045011,2
    C,F,H--49070766(+) CCCAGC/TGGAAG 1 -- us2k18Minor allele frequency- T:0.05NA NS EA WA 670
    rs1832311111,2
    --49070876(+) GATGGG/TCAAGA 1 -- us2k10--------
    rs1452857081,2
    --49071022(+) GTTACC/TGATTC 1 -- us2k10--------
    rs1491645011,2
    C--49071037(+) AATTCA/GCGAGT 1 -- us2k10--------
    rs1432669191,2
    C--49071049(+) GGGCCC/TAAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARG2 (68086515 - 68118437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470651CNV Gain18288195
    nsv902066CNV Gain21882294
    nsv902068CNV Gain21882294
    nsv456331CNV Gain19166990

    Locus Specific Mutation Databases (LSDB): ARG2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107830    OMIM disorders: --

    1 disease for ARG2:    
    About MalaCards
    hyperargininemia


    Find genes that share disorders with ARG2           About GenesLikeMe

    9 Novoseek inferred disease relationships for ARG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperargininemia 90.8 1 8454280 (1)
    erectile dysfunction 34.9 5 11350073 (2), 11370664 (1), 12859189 (1)
    asthma 30.2 10 19281908 (2), 19286931 (2), 16387594 (1), 12813022 (1)
    hyperplasia 14.5 1 18319562 (1)
    myopathy 13.3 1 11370664 (1)
    inflammation 0 3 19286931 (1), 19486531 (1)
    atherosclerosis 0 1 18309100 (1)
    tumors 0 15 18528866 (5), 18663728 (4), 18817562 (2), 18202758 (1) (see all 5)
    cancer 0 2 18817562 (1), 18663728 (1)

    Genetic Association Database (GAD): ARG2
    Human Genome Epidemiology (HuGE) Navigator: ARG2 (6 documents)

    Export disorders for ARG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARG2 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with ARG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. (PubMed id 8898077)1, 2, 3, 9 Gotoh T.... Mori M. (FEBS Lett. 1996)
    2. Cloning and characterization of the human type II arginase gene. (PubMed id 8954792)1, 2, 3, 9 Vockley J.G....Cederbaum S.D. (Genomics 1996)
    3. Human arginase II: crystal structure and physiological role in male and female sexual arousal. (PubMed id 12859189)1, 2, 9 Cama E.... Christianson D.W. (Biochemistry 2003)
    4. Roles of arginase variants, atopy, and ozone in childhood asthma. (PubMed id 19281908)1, 4, 9 Salam M.T....Gilliland F.D. (J. Allergy Clin. Immunol. 2009)
    5. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. (PubMed id 16387594)1, 4, 9 Li H....London S.J. (J. Allergy Clin. Immunol. 2006)
    6. Human type II arginase: sequence analysis and tissue-specific expression. (PubMed id 9256072)1, 2, 9 Morris S.M. Jr.... Kepka-Lenhart D. (Gene 1997)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. (PubMed id 20124949)1, 4 Vonk J.M....Meurs H. (Pharmacogenet. Genomics 2010)
    9. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 384 HGNC: 664 AceView: ARG2 Ensembl:ENSG00000081181 euGenes: HUgn384
    ECgene: ARG2 Kegg: 384 H-InvDB: ARG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARG2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Arginase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARG2 gene:
    Search GeneIP for patents involving ARG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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