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Aliases for ARG2 Gene

Aliases for ARG2 Gene

  • Arginase 2 2 3 5
  • EC 3.5.3.1 4 61
  • Kidney-Type Arginase 4
  • Non-Hepatic Arginase 4
  • Arginase, Type II 2
  • Type II Arginase 4
  • EC 3.5.3 61

External Ids for ARG2 Gene

Previous GeneCards Identifiers for ARG2 Gene

  • GC14P065591
  • GC14P061880
  • GC14P066076
  • GC14P067156
  • GC14P068086
  • GC14P048256

Summaries for ARG2 Gene

Entrez Gene Summary for ARG2 Gene

  • Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARG2 Gene

ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include Impotence and Exudative Vitreoretinopathy 1. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include arginase activity. An important paralog of this gene is ARG1.

UniProtKB/Swiss-Prot for ARG2 Gene

  • May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARG2 Gene

Genomics for ARG2 Gene

Regulatory Elements for ARG2 Gene

Enhancers for ARG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F067668 0.4 ENCODE 23.8 +48.7 48690 0.8 MTA2 JUNB EBF1 TBX21 RAD51 JUND IKZF1 TARDBP NBN MLLT1 ARG2 RDH11 ENSG00000201529 PIGH RDH12 RN7SL369P VTI1B GC14M067658
GH14F067645 0.5 ENCODE 23.2 +26.5 26527 0.7 MAFK ARG2 RDH11 ENSG00000201529 GC14M067653
GH14F067622 0.5 Ensembl ENCODE 21.3 +3.4 3354 2.1 ELF3 PKNOX1 CBX3 ARID4B FEZF1 ZNF2 BRCA1 RARA ZNF335 CREM ARG2 ENSG00000259502 GC14M067653
GH14F067665 0.8 Ensembl ENCODE 21.3 +47.1 47060 2.1 CTCF TFAP4 ZNF654 ARID4B TRIM22 REST RAD21 YY1 ZNF316 IKZF1 ARG2 PIGH ENSG00000201529 RDH11 RDH12 RN7SL369P VTI1B GC14M067658
GH14F067703 1.2 Ensembl ENCODE 20.8 +84.6 84603 1.2 ZSCAN5A CTCF SAP130 ZNF266 RAD21 RFX5 ZNF664 ZBTB48 SCRT2 ZNF143 ARG2 PIGH ENSG00000201529 PLEK2 RDH12 RN7SL369P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARG2 on UCSC Golden Path with GeneCards custom track

Promoters for ARG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000419676 202 1601 HDGF ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS SP3 SP5

Genomic Location for ARG2 Gene

Chromosome:
14
Start:
67,619,798 bp from pter
End:
67,651,720 bp from pter
Size:
31,923 bases
Orientation:
Plus strand

Genomic View for ARG2 Gene

Genes around ARG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARG2 Gene

Proteins for ARG2 Gene

  • Protein details for ARG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78540-ARGI2_HUMAN
    Recommended name:
    Arginase-2, mitochondrial
    Protein Accession:
    P78540
    Secondary Accessions:
    • B2R690
    • Q6FHY8

    Protein attributes for ARG2 Gene

    Size:
    354 amino acids
    Molecular mass:
    38578 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for ARG2 Gene

neXtProt entry for ARG2 Gene

Post-translational modifications for ARG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARG2 (ARG2)

Domains & Families for ARG2 Gene

Gene Families for ARG2 Gene

IUPHAR :

Suggested Antigen Peptide Sequences for ARG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78540

UniProtKB/Swiss-Prot:

ARGI2_HUMAN :
  • Belongs to the arginase family.
Family:
  • Belongs to the arginase family.
genes like me logo Genes that share domains with ARG2: view

Function for ARG2 Gene

Molecular function for ARG2 Gene

GENATLAS Biochemistry:
arginase 2,expressed in extra hepatic tissues,putatively involved in nitric oxide synthesis
UniProtKB/Swiss-Prot CatalyticActivity:
L-arginine + H(2)O = L-ornithine + urea.
UniProtKB/Swiss-Prot Function:
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

Enzyme Numbers (IUBMB) for ARG2 Gene

Gene Ontology (GO) - Molecular Function for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004053 arginase activity IMP,TAS 16128822
GO:0016787 hydrolase activity IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARG2: view
genes like me logo Genes that share phenotypes with ARG2: view

Animal Models for ARG2 Gene

MGI Knock Outs for ARG2:

Animal Model Products

miRNA for ARG2 Gene

miRTarBase miRNAs that target ARG2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARG2 Gene

Localization for ARG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARG2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARG2 Gene COMPARTMENTS Subcellular localization image for ARG2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 2
chloroplast 1
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 8898077
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ARG2: view

Pathways & Interactions for ARG2 Gene

genes like me logo Genes that share pathways with ARG2: view

UniProtKB/Swiss-Prot P78540-ARGI2_HUMAN

  • Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Gene Ontology (GO) - Biological Process for ARG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
GO:0001657 ureteric bud development IEA --
GO:0006525 arginine metabolic process IEA --
GO:0006809 nitric oxide biosynthetic process TAS 8898077
GO:0006941 striated muscle contraction IEA --
genes like me logo Genes that share ontologies with ARG2: view

No data available for SIGNOR curated interactions for ARG2 Gene

Drugs & Compounds for ARG2 Gene

(13) Drugs for ARG2 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist, Target 0
Urea Approved Pharma 0
Manganese Approved Nutra 34
L-ornithine Approved Nutra Full agonist, Agonist, Target 0
Water Approved Pharma 0

(2) Additional Compounds for ARG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ARG2 Gene

Compound Action Cas Number
Arginase inhibitor 1 1345808-25-4
genes like me logo Genes that share compounds with ARG2: view

Transcripts for ARG2 Gene

Unigene Clusters for ARG2 Gene

Arginase, type II:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARG2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for ARG2 Gene

GeneLoc Exon Structure for
ARG2
ECgene alternative splicing isoforms for
ARG2

Expression for ARG2 Gene

mRNA expression in normal human tissues for ARG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARG2 Gene

This gene is overexpressed in Kidney - Cortex (x7.0), Pituitary (x4.6), and Prostate (x4.0).

Protein differential expression in normal tissues from HIPED for ARG2 Gene

This gene is overexpressed in Prostate (38.8), Islet of Langerhans (18.2), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARG2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARG2 Gene:

ARG2

SOURCE GeneReport for Unigene cluster for ARG2 Gene:

Hs.226007

mRNA Expression by UniProt/SwissProt for ARG2 Gene:

P78540-ARGI2_HUMAN
Tissue specificity: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
genes like me logo Genes that share expression patterns with ARG2: view

Primer Products

No data available for Protein tissue co-expression partners for ARG2 Gene

Orthologs for ARG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARG2 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ARG2 34 35
  • 91.89 (n)
cow
(Bos Taurus)
Mammalia ARG2 34 35
  • 90.11 (n)
mouse
(Mus musculus)
Mammalia Arg2 34 16 35
  • 85.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARG2 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arg2 34
  • 84.93 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARG2 34 35
  • 74.2 (n)
lizard
(Anolis carolinensis)
Reptilia ARG2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arg2 34
  • 70.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53991 34
zebrafish
(Danio rerio)
Actinopterygii arg2 34 35
  • 62.6 (n)
wufb67g02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008783 34
  • 48.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta arg 34 35
  • 47.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8475 35
  • 48 (a)
OneToMany
Species where no ortholog for ARG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARG2 Gene

ENSEMBL:
Gene Tree for ARG2 (if available)
TreeFam:
Gene Tree for ARG2 (if available)

Paralogs for ARG2 Gene

Paralogs for ARG2 Gene

(1) SIMAP similar genes for ARG2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARG2 Gene

genes like me logo Genes that share paralogs with ARG2: view

Variants for ARG2 Gene

Sequence variations from dbSNP and Humsavar for ARG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10134090 -- 67,618,995(+) GATTC(C/T)TGCAT intron-variant, upstream-variant-2KB
rs10143874 -- 67,623,883(+) tcact(C/T)aggct intron-variant
rs10144907 -- 67,619,023(+) aagaa(C/T)ttgga intron-variant, upstream-variant-2KB
rs10145465 -- 67,627,337(+) aatta(C/T)agggt intron-variant
rs10150006 -- 67,625,521(+) aaata(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARG2 Gene

Variant ID Type Subtype PubMed ID
nsv456331 CNV gain 19166990
nsv470651 CNV gain 18288195
nsv564961 CNV gain 21841781

Variation tolerance for ARG2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARG2 Gene

Disorders for ARG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARG2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
impotence
  • erectile dysfunction
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search ARG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARG2

Genetic Association Database (GAD)
ARG2
Human Genome Epidemiology (HuGE) Navigator
ARG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARG2
genes like me logo Genes that share disorders with ARG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARG2 Gene

Publications for ARG2 Gene

  1. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. (PMID: 8898077) Gotoh T. … Mori M. (FEBS Lett. 1996) 2 3 4 22 64
  2. Cloning and characterization of the human type II arginase gene. (PMID: 8954792) Vockley J.G. … Cederbaum S.D. (Genomics 1996) 2 3 4 22 64
  3. Roles of arginase variants, atopy, and ozone in childhood asthma. (PMID: 19281908) Salam M.T. … Gilliland F.D. (J. Allergy Clin. Immunol. 2009) 3 22 46 64
  4. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. (PMID: 16387594) Li H. … London S.J. (J. Allergy Clin. Immunol. 2006) 3 22 46 64
  5. Human arginase II: crystal structure and physiological role in male and female sexual arousal. (PMID: 12859189) Cama E. … Christianson D.W. (Biochemistry 2003) 3 4 22 64

Products for ARG2 Gene

Sources for ARG2 Gene

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