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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARG2 Gene

protein-coding   GIFtS: 64
GCID: GC14P068086

arginase, type II
 Explore 23 diseases affiliated with
ARG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARG2    

Aliases
for ARG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arginase, Type II1 2     Arginase-2, Mitochondrial2
Kidney-Type Arginase2 3     Kidney Arginase2
Non-Hepatic Arginase2 3     L-Arginine Amidinohydrolase2
Type II Arginase2 3     L-Arginine Ureahydrolase2
EC 3.5.3.13 8     Nonhepatic Arginase2
Arginase 22     EC 3.5.38

External Ids:    HGNC: 6641   Entrez Gene: 3842   Ensembl: ENSG000000811817   OMIM: 1078305   UniProtKB: P785403   

Export aliases for ARG2 gene to outside databases

Previous GC identifers: GC14P065591 GC14P061880 GC14P066076 GC14P067156 GC14P048256


Summaries
for ARG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARG2:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists
(types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and
physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in
extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to
play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use
of alternative polyadenylation sites have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of
nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since
NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina,
arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment
of male and female sexual arousal disorders




Genomic Views
for ARG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARG2 gene promoter:
         HOXA9B   HOXA9   NCX/Ncx   Pax-2   Pax-2a   RORalpha2   Pax-2b   STAT3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

ARG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P068086:  view genomic region     (about GC identifiers)

Start:
 68,086,515 bp from pter      End:
 68,118,437 bp from pter
Size:
 31,923 bases      Orientation:
 plus strand

Proteins
for ARG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540 (See protein sequence)
Recommended Name: Arginase-2, mitochondrial precursor  
Size: 354 amino acids; 38578 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Homotrimer
Subcellular location: Mitochondrion
1 PDB 3D structure from and Proteopedia for ARG2:
1PQ3 (3D)    
Secondary accessions: B2R690 Q6FHY8

Explore the universe of human proteins at neXtProt for ARG2: NX_P78540

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78540

    • 4/12 DME Specific Peptides for ARG2 (P78540) (see all 12)
     FGQTREG  HGPAAIR  GGDHSLA  DLVEVNP 

    ARG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001163.1  
    ENSEMBL proteins: 
     ENSP00000261783  
    Reactome Protein details: P78540
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for ARG2
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS8898077
    GO:0005759mitochondrial matrix TAS--


    ARG2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARG2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014033 Arginase
     IPR006035 Ureohydrolase
     IPR020855 Ureohydrolase_Mn_BS
     IPR023696 Ureohydrolase_domain

    Graphical View of Domain Structure for InterPro Entry P78540

    ProtoNet protein and cluster: P78540

    2 Blocks protein families:
    IPB005924 Arginase signature
    IPB006035 Arginase/agmatinase/formiminoglutamase


    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Similarity: Belongs to the arginase family


    Function
    for ARG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of
    nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since
    NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina,
    arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment
    of male and female sexual arousal disorders
    Catalytic activity: L-arginine + H(2)O = L-ornithine + urea

         Genatlas biochemistry entry for ARG2:
    arginase 2,expressed in extra hepatic tissues,putatively involved in nitric oxide synthesis

    Enzyme Numbers (IUBMB): EC 3.5.3.11 2 EC 3.5.32

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARG2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ARG2 (see all 9):
    hsa-miR-875-3p hsa-miR-3673 hsa-miR-206 hsa-miR-3611 hsa-miR-1 hsa-miR-1257 hsa-miR-1252 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: ARG2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARG2 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004053arginase activity EXP--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0050998nitric-oxide synthase binding ----


    ARG2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Arg2tm1Weo for ARG2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Arg2):
     homeostasis/metabolism 

    ARG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2superpathway of citrulline metabolism
    		superpathway of citrulline metabolism1.00
    		citrulline biosynthesis0.53
    3Arginine and proline metabolism
    		Arginine and proline metabolism1.00
    		Urea cycle and metabolism of amino groups0.36
    4proline biosynthesis II (from arginine)
    		arginine degradation VI (arginase 2 pathway)0.50
    		arginine degradation I (arginase pathway)0.14
    5glutamate degradation X
    		urea cycle0.00
    		Urea cycle0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6 BioSystems Pathways for ARG2 (see all 6) 
        arginine degradation I (arginase pathway)
    citrulline biosynthesis
    Urea cycle and metabolism of amino groups
    superpathway of citrulline metabolism
    arginine degradation VI (arginase 2 pathway)

    3        Reactome Pathways for ARG2
        Metabolism
    Metabolism of amino acids and derivatives
    Urea cycle


    3         Kegg Pathways  (Kegg details for ARG2):
        Arginine and proline metabolism
    Metabolic pathways
    Amoebiasis

    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1


    ARG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for ARG2 (P785403 ENSP000002617834) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARG1P050893, ENSP000003570664I2D: score=1 STRING: ENSP00000357066
    ADCENSP000002945174STRING: ENSP00000294517
    ASLENSP000003071884STRING: ENSP00000307188
    NOS1ENSP000003207584STRING: ENSP00000320758
    NOS2ENSP000003272514STRING: ENSP00000327251
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000050urea cycle TAS--
    GO:0001657ureteric bud development IEA--
    GO:0001666response to hypoxia ----
    GO:0006525arginine metabolic process IEA--
    GO:0006809nitric oxide biosynthetic process TAS8898077


    ARG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARG2 for compounds           About GeneDecksing

    EMD Millipore small molecules for ARG2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ARG2

    Browse Tocris compounds for ARG2

    5 HMDB Compounds for ARG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    Manganesemanganese 7439-96-5--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    UreaCarbonyl diamine (see all 90)57-13-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for ARG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--15548540 12874210 14871882 15753084 15539552
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--16801455 16979358
    S-2-(Boronoethyl)-L-Cysteine-- --target--17139284 17016423

    10/11 Novoseek chemical compound relationships for ARG2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-2-(boronoethyl)-l-cysteine 94.6 5 11478904 (2), 17008605 (1)
    2(s)-amino-6-boronohexanoic acid 87.4 3 11478904 (2)
    ornithine 83.5 18 11370664 (2), 9131018 (2), 9874001 (1), 19000307 (1) (see all 15)
    arginine 78.8 44 18817562 (6), 11370664 (3), 9131018 (2), 19545540 (2) (see all 21)
    urea 71.8 21 11370664 (2), 17680661 (2), 9131018 (1), 19545540 (1) (see all 10)
    nitric oxide 64.1 21 8898077 (2), 11370664 (1), 12415579 (1), 16801455 (1) (see all 14)
    proline 48.4 3 11370664 (1), 20107769 (1), 8954792 (1)
    manganese 31.2 2 16128822 (2)
    oxygen 0 1 18309100 (1)
    glutamate 0 1 11370664 (1)

    Search CenterWatch for drugs/clinical trials and news about ARG2 / ARGI2 

    Transcripts
    for ARG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARG2 gene: 
    NM_001172.3  

    Unigene Cluster for ARG2:

    Arginase, type II
    Hs.226007  [show with all ESTs]
    Unigene Representative Sequence: BC029050
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261783(uc001xjs.3) ENST00000557120 ENST00000556491 ENST00000557319


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK312484.1 AY074489.1 BC001350.1 BC008464.1 BC029050.1 CR536550.1 D86724.1 U75667.1 
    U82256.1 

    18 DOTS entries:

    DT.86845723  DT.97772353  DT.100786613  DT.40116859  DT.80100028  DT.91936909  DT.99995824  DT.318788 
    DT.100786614  DT.100798309  DT.120767699  DT.120767834  DT.120767693  DT.92055345  DT.92055625  DT.95170341 
    DT.99959305  DT.92046439 

    24/155 AceView cDNA sequences (see all 155):

    NM_001172 BC008464 BQ636750 AA679821 F12274 BM463537 BQ717281 CB131607 
    BQ430251 AU151115 BG394222 CR536550 AY074489 BG826499 T08456 BP358110 
    AA848055 AI282597 F15256 D86724 CR595402 BI821051 CA389807 AA506721 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARG2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                            -                           
    SP2:                                                                        
    SP3:                                -                                       
    SP4:                                                                        


    ECgene alternative splicing isoforms for ARG2

    Expression
    for ARG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCACAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    HeartAtrioventricular CanalHeart
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    Mature airway epithelial cells (Directed differentia...)

    See ARG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARG2

    SOURCE GeneReport for Unigene cluster: Hs.226007

    UniProtKB/Swiss-Prot: ARGI2_HUMAN, P78540
    Tissue specificity: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle,
    placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARG2: 
              Hypertension in human mouse rat
              Amino Acid Metabolism I in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

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    In Situ
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    Orthologs
    for ARG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARG2 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arg21 , 5 arginase type II1, 5 85.88(n)1
    84.75(a)1    		   12 (35.51 cM)5
    118471  NM_009705.31  NP_033835.11 
     791307775 
    chicken
    (Gallus gallus)    		 Aves ARG21 arginase, type II 74.2(n)
    74.58(a)    		   423272  NM_001199704.1  NP_001186633.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARG26
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343272.1(989386-1005932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC539912 similar to arginase 75.42(n)    U08406.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb67g022 wufb67g02 70.02(n)   322614  BC056711.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta arg1 arginase 47.18(n)
    42.86(a)    		   46717  NM_080136.2  NP_524875.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea T21F4.16
    		 --
    		 18(a)
    		 possible ortholog
    		 X(5630321-5638063)


    ENSEMBL Gene Tree for ARG2 (if available)
    TreeFam Gene Tree for ARG2 (if available) 

    Paralogs
    for ARG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARG2 gene
    AGMAT2  ARG12  
    1 SIMAP similar gene for ARG2 using alignment to 1 protein entry:     ARGI2_HUMAN:
    ARG1

    ARG2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARG2
    PGOHUM00000243721


    Genomic Variants
    for ARG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/579 NCBI SNPs in ARG2 are shown (see all 579)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs171045011,2
    		C,F,H,--48254440(+) CCCAGC/TGGAAG 1 -- us2k18Minor allele frequency- T:0.05NA NS EA WA 670
    rs1129177591,2
    		C,--48254848(+) CTGAGA/GTGCAG 1 -- us2k12Minor allele frequency- G:0.07WA 120
    rs118496001,2
    		C,F,H,--48255387(+) TAAAAA/GATTAA 1 -- us2k1 tfbs312Minor allele frequency- G:0.09NS EA NA WA 1594
    rs101340901,2
    		C,F,H,--48255418(+) GATTCT/CTGCAT 1 -- us2k114Minor allele frequency- C:0.07NS EA NA WA 1520
    rs101449071,2
    		C,F,H,--48255446(+) aagaaC/Tttgga 1 -- us2k110Minor allele frequency- T:0.08NS EA NA WA 1208
    rs801119611,2
    		--48255524(+) TTCTTC/TGCTTT 1 -- us2k10--------
    rs758868961,2
    		--48256004(+) GTGTCG/CGCTCC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs171045121,2
    		C,F,H,--48256111(+) TATTGG/CCCTTC 1 -- us2k118Minor allele frequency- C:0.06NA NS EA WA 1768
    rs285474991,2
    		F,--48256147(+) CTGGCC/GGGAGA 1 -- us2k11Minor allele frequency- G:0.12WA 118
    rs752151281,2
    		--48256195(+) TCCCAG/CCCTTG 1 -- us2k11Minor allele frequency- C:0.01EA 120

    HapMap Linkage Disequilibrium report for ARG2 (68086515 - 68118437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARG2: --
    Locus Specific Mutation Databases (LSDB): ARG2

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    Disorders / Diseases
    for ARG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARG2 for disorders           About GeneDecksing

    OMIM gene information: 107830    OMIM disorders: --

    20/23 diseases for ARG2 (see all 23):    About MalaCards
    hepatitis    hyperargininemia    anorexia nervosa    sickle cell disease
    spondyloarthropathy    renal cell carcinoma    diabetes mellitus    atopy
    asthma    atherosclerosis    glomerulonephritis    hepatocellular carcinoma
    peritonitis    thyroiditis    lung cancer    prostate cancer
    breast cancer    hypertension    carcinoma    hypoxia

    1 disease from the University of Copenhagen DISEASES database for ARG2:
    Hyperargininemia

    9 Novoseek disease relationships for ARG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperargininemia 90.8 1 8454280 (1)
    erectile dysfunction 34.9 5 11350073 (2), 11370664 (1), 12859189 (1)
    asthma 30.2 10 19281908 (2), 19286931 (2), 16387594 (1), 12813022 (1)
    hyperplasia 14.5 1 18319562 (1)
    myopathy 13.3 1 11370664 (1)
    inflammation 0 3 19286931 (1), 19486531 (1)
    atherosclerosis 0 1 18309100 (1)
    tumors 0 15 18528866 (5), 18663728 (4), 18817562 (2), 18202758 (1) (see all 5)
    cancer 0 2 18817562 (1), 18663728 (1)

    Genetic Association Database (GAD): ARG2
    Human Genome Epidemiology (HuGE) Navigator: ARG2 (6 documents)

    Export disorders for ARG2 gene to outside databases

    Publications
    for ARG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARG2 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with ARG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. (PubMed id 8898077)1, 2, 3, 9 Gotoh T....Mori M. (1996)
    2. Cloning and characterization of the human type II arginase gene. (PubMed id 8954792)1, 2, 3, 9 Vockley J.G....Cederbaum S.D. (1996)
    3. Human arginase II: crystal structure and physiological role in male and female sexual arousal. (PubMed id 12859189)1, 2, 9 Cama E.... Christianson D.W. (2003)
    4. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. (PubMed id 16387594)1, 4, 9 Li H....London S.J. (2006)
    5. Human type II arginase: sequence analysis and tissue-specific expression. (PubMed id 9256072)1, 2, 9 Morris S.M. Jr.... Kepka-Lenhart D. (1997)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression of arginase II in prostate cancer. (PubMed id 18202758)1, 9 Mumenthaler S.M....Grody W.W. (2008)
    8. Expression, purification, and characterization of human type II arginase. (PubMed id 11370664)1, 9 Colleluori D.M....Ash D.E. (2001)
    9. Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. (PubMed id 18528866)1, 9 Rotondo R....Frumento G. (2008)
    10. Identification of arginase in human placental villi. (PubMed id 16720041)1, 9 Ishikawa T....Aso T. (2007)

    External Searches for ARG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 384 HGNC: 664 AceView: ARG2 Ensembl:ENSG00000081181 euGenes: HUgn384
    ECgene: ARG2 Kegg: 384 H-InvDB: ARG2

    Other Databases showing ARG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARG2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Arginase

    Intellectual Property
    for ARG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARG2 gene:
    Search GeneIP for patents involving ARG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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