Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARG1 Gene

protein-coding   GIFtS: 73
GCID: GC06P131936

Arginase 1

(Previous names: arginase, liver)
  See ARG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Arginase 11 2
Arginase, Liver1 2
Liver-Type Arginase2 3
Type I Arginase2 3
EC 3.5.3.13 8
arginase-12

External Ids:    HGNC: 6631   Entrez Gene: 3832   Ensembl: ENSG000001185207   OMIM: 6083135   UniProtKB: P050893   

Export aliases for ARG1 gene to outside databases

Previous GC identifers: GC06P131553 GC06P131741 GC06P131874 GC06P129475


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARG1 Gene:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase
exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic
crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and
expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme
results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for ARG1 Gene:
ARG1 (arginase 1) is a protein-coding gene. Diseases associated with ARG1 include hyperargininemia, and quadriplegia. GO annotations related to this gene include manganese ion binding. An important paralog of this gene is ARG2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARG1 gene promoter:
         SRF   AML1a   p53   ATF-2   SRF (504 AA)   LCR-F1   GATA-1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARG1 promoter sequence
   Search Chromatin IP Primers for ARG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

ARG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARG1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P131936:  view genomic region     (about GC identifiers)

Start:
131,894,284 bp from pter      End:
131,905,472 bp from pter
Size:
11,189 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARGI1_HUMAN, P05089 (See protein sequence)
Recommended Name: Arginase-1  
Size: 322 amino acids; 34735 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Homotrimer
Selected PDB 3D structures from and Proteopedia for ARG1 (see all 36):
1WVA (3D)        1WVB (3D)        2AEB (3D)        2PHA (3D)        2PHO (3D)        2PLL (3D)    
Secondary accessions: A6NEA0 Q5JWT5 Q5JWT6 Q8TE72 Q9BS50
Alternative splicing: 3 isoforms:  P05089-1   P05089-2   P05089-3   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARG1: NX_P05089

Explore proteomics data for ARG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ARG1 (P05089) (see all 10)
     VIWVDAH  GGDHSLA  KTGLLSG  AIGSISG 


    See ARG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000036.2  NP_001231367.1  

    ENSEMBL proteins: 
     ENSP00000357066   ENSP00000349446  
    Reactome Protein details: P05089

    ARG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ARG1 (Arginase 1/ARG1)
    Enzo Life Sciences proteins for ARG1
    OriGene Purified Protein for ARG1
    OriGene Protein Over-expression Lysate for ARG1
    OriGene MassSpec for ARG1
    OriGene Custom Protein Services for ARG1
    GenScript Custom Purified and Recombinant Proteins Services for ARG1
    Novus Biologicals ARG1 Proteins
    Novus Biologicals ARG1 Lysates
    Sino Biological Recombinant Protein for ARG1
    Sino Biological Cell Lysate for ARG1
    ProSpec Recombinant Protein for ARG1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ARG1 

     
    antibodies-online proteins for ARG1 (21 products) 

     
    antibodies-online peptides for ARG1

    ARG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARG1
    R&D Systems Antibodies for ARG1 (Arginase 1/ARG1)
    Cell Signaling Technology (CST) Antibodies for ARG1 
    OriGene Antibodies for ARG1
    OriGene Custom Antibody Services for ARG1
    Novus Biologicals ARG1 Antibodies
    Abcam antibodies for ARG1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ARG1
    antibodies-online antibodies for ARG1 (113 products) 

    ARG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ARG1 
    antibodies-online kits for ARG1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Arginase I
    Arginase

    4 InterPro protein domains:
     IPR014033 Arginase
     IPR006035 Ureohydrolase
     IPR023696 Ureohydrolase_domain
     IPR020855 Ureohydrolase_Mn_BS

    Graphical View of Domain Structure for InterPro Entry P05089

    ProtoNet protein and cluster: P05089

    2 Blocks protein domains:
    IPB005924 Arginase signature
    IPB006035 Arginase/agmatinase/formiminoglutamase


    UniProtKB/Swiss-Prot: ARGI1_HUMAN, P05089
    Similarity: Belongs to the arginase family


    Find genes that share domains with ARG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARGI1_HUMAN, P05089
    Catalytic activity: L-arginine + H(2)O = L-ornithine + urea
    Induction: By arginine or homoarginine

         Genatlas biochemistry entry for ARG1:
    arginase,liver,ornithine metabolism,urea cycle,cytoplasmic

         Enzyme Number (IUBMB): EC 3.5.3.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004053arginase activity EXP--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
    GO:0030145manganese ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ARG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARG1:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Arg1):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with ARG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ARG1: Arg1tm1Rki Arg1tm1.1Pmu

       genOway: Develop your customized and physiologically relevant rodent model for ARG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARG1:
    hsa-mir-7-5p (MIRT025899), hsa-mir-30a-5p (MIRT028633), hsa-mir-1 (MIRT024079)

    Block miRNA regulation of human, mouse, rat ARG1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ARG1:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidARG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARG1
    Predesigned siRNA for gene silencing in human, mouse, rat ARG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARG1

    Clone
    Products:
         
    OriGene clones in human, mouse for ARG1 (see all 7)
    OriGene ORF clones in mouse, rat for ARG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARG1 (NM_000045)
    Sino Biological Human cDNA Clone for ARG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARGI1_HUMAN, P05089: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm TAS3540966
    GO:0005829cytosol TAS--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with ARG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARG1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Arginine and proline metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups0.00
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Urea cycle0.00
    4Carbon metabolism
    Biosynthesis of amino acids0.38
    5Spinal Cord Injury
    Spinal Cord Injury


    Find genes that share SuperPaths with ARG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARG1
        NgR-p75(NTR)-Mediated Signaling

    1 Cell Signaling Technology (CST) Pathway for ARG1
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ARG1
        NO-dependent CFTR activation (normal and CF)

    4 BioSystems Pathways for ARG1
        Spinal Cord Injury
    IL4-mediated signaling events
    ATF-2 transcription factor network
    Urea cycle and metabolism of amino groups


    1 Reactome Pathway for ARG1
        Urea cycle


    4 Kegg Pathways  (Kegg details for ARG1):
        Arginine and proline metabolism
    Metabolic pathways
    Biosynthesis of amino acids
    Amoebiasis

    UniProtKB/Swiss-Prot: ARGI1_HUMAN, P05089
    Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARG1: 

              Neurotoxicity in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARG1 (P050892, 3 ENSP000003570664) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206379O759552, 3, ENSP000003728734MINT-3974680 I2D: score=3 STRING: ENSP00000372873
    ENSG00000206480O759552, 3MINT-3974680 I2D: score=3 
    ENSG00000230143O759552, 3MINT-3974680 I2D: score=3 
    ENSG00000232280O759552, 3MINT-3974680 I2D: score=3 
    FLOT1O759552, 3, ENSP000003655694MINT-3974680 I2D: score=3 STRING: ENSP00000365569
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000050urea cycle TAS--
    GO:0001889liver development IEA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0006525arginine metabolic process ----
    GO:0006527arginine catabolic process TAS3540966

    Find genes that share ontologies with ARG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ARG1
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARG1 (ARGI1)

    5 HMDB Compounds for ARG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    Manganesemanganese 7439-96-5--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    UreaCarbonyl diamine (see all 90)57-13-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for ARG1 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--12589193 12135320 12446178 12679340 11971019
    2(S)-Amino-6-Boronohexanoic Acid-- --target--17139284 17016423 10592235
    Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine-- --target--17139284 17016423 10592235
    Dinor-N(Omega)-Hydroxy-L-Arginine-- --target--17139284 17016423 10592235
    N-Omega-Hydroxy-L-Arginine-- --target--17139284 17016423 10592235
    Nor-N-Omega-Hydroxy-L-Arginine-- --target--17139284 17016423 10592235
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423 10592235
    S-2-(Boronoethyl)-L-Cysteine-- --target--17139284 17016423 10592235
    S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine-- --target--17139284 17016423 10592235
    Urea-- 57-13-6target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for ARG1 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2(s)-amino-6-boronohexanoic acid 89.3 7 16141327 (2), 17562323 (1), 11478904 (1)
    ornithine 86.4 28 9874001 (2), 11370664 (2), 17098461 (2), 17708746 (2) (see all 19)
    arginine 83.7 104 15780765 (3), 15289616 (3), 17708746 (3), 19577247 (2) (see all 52)
    s-2-(boronoethyl)-l-cysteine 82.3 4 11478904 (1), 16141327 (1)
    urea 69.9 16 17098461 (2), 9874001 (1), 11370664 (1), 9131018 (1) (see all 12)
    manganese 64.2 10 12820884 (1), 17469833 (1), 10872443 (1), 17252946 (1) (see all 10)
    nitric oxide 63 59 11080091 (6), 17119118 (2), 17194896 (2), 17291856 (2) (see all 30)
    citrulline 59.8 1 19638312 (1)
    agmatine 58.3 1 16094464 (1)
    proline 55.6 7 17252946 (3), 11370664 (1), 9636659 (1), 20107769 (1) (see all 5)

    3 PharmGKB related drug/compound annotations for ARG1 gene    About this table
    Drug/compound PharmGKB Annotation
    phenylacetic acid
    selective beta-2-adrenoreceptor agonistsCA  
    sodium benzoate



    Find genes that share compounds with ARG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARG1 gene (2 alternative transcripts): 
    NM_000045.3  NM_001244438.1  

    Unigene Cluster for ARG1:

    Arginase, liver
    Hs.440934  [show with all ESTs]
    Unigene Representative Sequence: AK128314
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368087(uc003qco.2 uc003qcp.2 uc010kfm.2) ENST00000469293
    ENST00000356962 ENST00000275196 ENST00000498260 ENST00000484820
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARG1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ARG1:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidARG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARG1
    Predesigned siRNA for gene silencing in human, mouse, rat ARG1
    Clone
    Products:
         
    OriGene clones in human, mouse for ARG1 (see all 7)
    OriGene ORF clones in mouse, rat for ARG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARG1 (NM_000045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARG1
      QuantiTect SYBR Green Assays in human, mouse, rat ARG1
      QuantiFast Probe-based Assays in human, mouse, rat ARG1

    Additional mRNA sequence: 

    AK128314.1 AY074488.1 BC005321.1 BC020653.1 BT006741.1 M14502.1 

    14 DOTS entries:

    DT.115141  DT.95173781  DT.91772406  DT.121372519  DT.446742  DT.75196334  DT.95173777  DT.95262884 
    DT.100796734  DT.100796737  DT.100727541  DT.406880  DT.95151751  DT.95364047 

    Selected AceView cDNA sequences (see all 147):

    CB162352 BC005321 NM_000045 N68409 CB163950 AA453673 BU657257 N91204 
    CB161540 AL601926 AK128314 AL596878 R01795 CB154102 M14502 BC020653 
    BG562548 BM729221 CB162422 CB164753 CR615342 BX494188 BG617358 CB163226 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTCAAAA
    ARG1 Expression
    About this image


    ARG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primordial Germ Cells Allantois
    ARG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440934
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARG1: 
              Neurotoxicity in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARG1
    QuantiTect SYBR Green Assays in human, mouse, rat ARG1
    QuantiFast Probe-based Assays in human, mouse, rat ARG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARG1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arg11 , 5 arginase, liver1, 5 83.13(n)1
    86.96(a)1
      10 (12.26 cM)5
    118461  NM_007482.31  NP_031508.11 
     249152085 
    African clawed frog
    (Xenopus laevis)
    Amphibia arg1-prov2 arginase 75.74(n)    BC043635.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arg11 arginase, liver 64.54(n)
    62.94(a)
      570368  NM_001045197.1  NP_001038662.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta arg6
    arginase
    35(a)
    1 → many
    X(403451-422067)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAR1(YPL111W)4
    CAR11
    Arginase, responsible for arginine degradation, expression more4
    CAR11
    48.22(n)1
    43.69(a)1
      16(339944-340945)4
    8559931, 4  NP_015214.11, 4 


    ENSEMBL Gene Tree for ARG1 (if available)
    TreeFam Gene Tree for ARG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARG1 gene
    ARG22  AGMAT2  
    1 SIMAP similar gene for ARG1 using alignment to 1 protein entry:     ARGI1_HUMAN:
    ARG2

    Find genes that share paralogs with ARG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARG1 (see all 38)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289414741,2,,4
    CArgininemia (ARGIN)4 pathogenic1131895689(+) GATTAC/TTGGAG 4 T I mis1 ese30--------
    VAR_0006744
    Argininemia (ARGIN)4--see VAR_0006742 G R mis40--------
    VAR_0155954
    Argininemia (ARGIN)4--see VAR_0155952 G V mis40--------
    rs1822891461,2
    --131893133(+) CCTATC/TTGGAA 2 -- us2k10--------
    rs27816651,2
    C,F,A,H--131893247(+) TGGGGA/TTACAG 2 -- us2k112Minor allele frequency- T:0.41NS EA WA NA CSA 771
    rs26088971,2
    C,F,O,A,H--131893463(-) GGGAAG/AGTGTC 2 -- us2k124Minor allele frequency- A:0.46NS EA NA WA CSA 2553
    rs748333281,2
    C,F--131893528(+) ATCCCG/AACTTT 2 -- us2k11Minor allele frequency- A:0.10WA 118
    rs603893581,2
    C,F--131893557(+) GGCAAC/TGGGTC 2 -- us2k14Minor allele frequency- T:0.12WA NA 242
    rs1385850021,2
    --131893558(+) GCAACA/GGGTCT 2 -- us2k10--------
    rs27816661,2
    C,F,O,A,H--131893559(+) CAACGG/TGTCTG 2 -- us2k120Minor allele frequency- T:0.42NA NS EA WA CSA 1768

    HapMap Linkage Disequilibrium report for ARG1 (131894284 - 131905472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886668CNV Gain21882294

    Human Gene Mutation Database (HGMD): ARG1
    Locus Specific Mutation Databases (LSDB): ARG1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARG1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608313   
    OMIM disorders: 207800  
    UniProtKB/Swiss-Prot: ARGI1_HUMAN, P05089
  • Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is
    elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations
    include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic
    quadriplegia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for ARG1:    
    About MalaCards
    hyperargininemia    quadriplegia    q fever    spastic quadriplegia
    recessive dystrophic epidermolysis bullosa    autoimmune hepatitis    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for ARG1:
    Hyperargininemia

    Find genes that share disorders with ARG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ARG1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperargininemia 93.7 20 10502833 (2), 15565656 (2), 1463019 (1), 11883902 (1) (see all 13)
    hyperammonemia 57.8 5 15465784 (1), 8454280 (1), 15050972 (1), 9608538 (1)
    hepatitis autoimmune 41.4 4 11750286 (2), 10520898 (2)
    asthma 32.9 30 19281908 (5), 19286931 (4), 20124949 (4), 17015747 (2) (see all 7)
    inflammation 30.1 9 19286931 (2), 19737603 (1), 19486531 (1), 20483789 (1) (see all 7)
    infection chronic 28.2 1 16186186 (1)
    hepatocellular carcinoma 26.7 1 19138817 (1)
    molecular pathology 22.5 1 1598908 (1)
    liver diseases 19.3 6 11676974 (4), 8387407 (1), 10520898 (1)
    tumors 14.7 26 15313928 (6), 19414774 (2), 8124860 (1), 18828017 (1) (see all 9)

    Genatlas disease: ARG1
    argininemia,with progressive spastic quadriplegia and mental retardation

    GeneTests: ARG1
    GeneReviews: ARG1
    Genetic Association Database (GAD): ARG1
    Human Genome Epidemiology (HuGE) Navigator: ARG1 (18 documents)

    Export disorders for ARG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARG1 gene, integrated from 10 sources (see all 266):
    (articles sorted by number of sources associating them with ARG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. (PubMed id 20124949)1, 4, 9 Vonk J.M....Meurs H. (Pharmacogenet. Genomics 2010)
    2. Roles of arginase variants, atopy, and ozone in childhood asthma. (PubMed id 19281908)1, 4, 9 Salam M.T....Gilliland F.D. (J. Allergy Clin. Immunol. 2009)
    3. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. (PubMed id 16387594)1, 4, 9 Li H....London S.J. (J. Allergy Clin. Immunol. 2006)
    4. Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure. (PubMed id 19303401)1, 4, 9 Meroufel D....Brousseau T. (Clin. Biochem. 2009)
    5. Expression of human liver arginase in Escherichia coli. Purification and properties of the product. (PubMed id 2241902)1, 2, 9 Ikemoto M....Murachi T. (Biochem. J. 1990)
    6. Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. (PubMed id 17369504)1, 4, 9 Dumont J....Brousseau T. (J. Med. Genet. 2007)
    7. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. (PubMed id 17469833)1, 2, 9 Di Costanzo L.... Christianson D.W. (J. Am. Chem. Soc. 2007)
    8. Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. (PubMed id 1463019)1, 2, 9 Uchino T.... Matsuda I. (Am. J. Hum. Genet. 1992)
    9. Molecular genetic study of human arginase deficiency. (PubMed id 1598908)1, 2, 9 Grody W.W....Cederbaum S.D. (Am. J. Hum. Genet. 1992)
    10. Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. (PubMed id 22959135)1, 3 Carvalho D.R....Pratesi R. (Gene 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 383 HGNC: 663 AceView: ARG1 Ensembl:ENSG00000118520 euGenes: HUgn383
    ECgene: ARG1 Kegg: 383 H-InvDB: ARG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARG1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ARG1[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Arginase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARG1 gene:
    Search GeneIP for patents involving ARG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ARG1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ARG1 (Arginase 1/ARG1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ARG1 (Arginase 1/ARG1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARG1   OriGene RNAi products in human, mouse, rat for ARG1  
     OriGene qPCR primer pairs and template standards for ARG1   OriGene Protein Over-expression Lysate for ARG1  
     OriGene MassSpec for ARG1   OriGene clones in human, mouse for ARG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARG1   OriGene Purified Protein for ARG1  
     OriGene ORF clones in mouse, rat for ARG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARG1   OriGene Custom Protein Services for ARG1  

     
     
     Block miRNA regulation of human, mouse, rat ARG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARG1 Predesigned siRNA for gene silencing in human, mouse, rat ARG1
     QuantiFast Probe-based Assays in human, mouse, rat ARG1 QuantiTect SYBR Green Assays in human, mouse, rat ARG1
     PCR Arrays including human, mouse, rat ARG1 Search Chromatin IP Primers for ARG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARG1  GeneGlobe Interaction Network for ARG1
     Regulatory tfbs in ARG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARG1 GenScript cDNA clones with any tag delivered in your preferred vector for ARG1
     GenScript Custom Assay Services for ARG1 GenScript Custom overexpressing Cell Line Services for ARG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ARG1 

     Search Tocris compounds for ARG1 (ARGI1)
     Proteins for ARG1
     Cell Lysates for ARG1
     cDNA Clones for ARG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for ARG1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARG1 antibodies
     ARG1 proteins
     ARG1 lysates
     Antibodies for ARG1
     See all of Abcam's Antibodies, Kits and Proteins for ARG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ARG1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARG1
     SwitchGear 3'UTR luciferase reporter plasmids for ARG1
     SwitchGear Promoter luciferase reporter plasmids for ARG1
     ThermoFisher Antibody for ARG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARG1
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARG1
      Search eBioscience for proteins for ARG1
      Search eBioscience for elisas for ARG1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ARG1
     antibodies-online antibodies for ARG1 (113 products)
     antibodies-online kits for ARG1 (10 products)
     antibodies-online peptides for ARG1
     antibodies-online proteins for ARG1 (21 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARG1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4