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Aliases for ARG1 Gene

Aliases for ARG1 Gene

  • Arginase 1 2 3 5
  • EC 3.5.3.1 4 63
  • Liver-Type Arginase 4
  • Arginase, Liver 2
  • Type I Arginase 4

External Ids for ARG1 Gene

Previous GeneCards Identifiers for ARG1 Gene

  • GC06P131741
  • GC06P131874
  • GC06P131936
  • GC06P129475

Summaries for ARG1 Gene

Entrez Gene Summary for ARG1 Gene

  • Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARG1 Gene

ARG1 (Arginase 1) is a Protein Coding gene. Diseases associated with ARG1 include argininemia and intestinal schistosomiasis. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include manganese ion binding and arginase activity. An important paralog of this gene is ARG2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARG1 Gene

Genomics for ARG1 Gene

Regulatory Elements for ARG1 Gene

Promoters for ARG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARG1 Gene

Chromosome:
6
Start:
131,573,144 bp from pter
End:
131,584,332 bp from pter
Size:
11,189 bases
Orientation:
Plus strand

Genomic View for ARG1 Gene

Genes around ARG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARG1 Gene

Proteins for ARG1 Gene

  • Protein details for ARG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05089-ARGI1_HUMAN
    Recommended name:
    Arginase-1
    Protein Accession:
    P05089
    Secondary Accessions:
    • A6NEA0
    • Q5JWT5
    • Q5JWT6
    • Q8TE72
    • Q9BS50

    Protein attributes for ARG1 Gene

    Size:
    322 amino acids
    Molecular mass:
    34735 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for ARG1 Gene

    Alternative splice isoforms for ARG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARG1 Gene

Proteomics data for ARG1 Gene at MOPED

Selected DME Specific Peptides for ARG1 Gene

Post-translational modifications for ARG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ARG1 (Arginase 1/ARG1)
  • Cell Signaling Technology (CST) Antibodies for ARG1 (ARG1)

Domains & Families for ARG1 Gene

Gene Families for ARG1 Gene

IUPHAR :

Suggested Antigen Peptide Sequences for ARG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05089

UniProtKB/Swiss-Prot:

ARGI1_HUMAN :
  • Belongs to the arginase family.
Family:
  • Belongs to the arginase family.
genes like me logo Genes that share domains with ARG1: view

Function for ARG1 Gene

Molecular function for ARG1 Gene

GENATLAS Biochemistry:
arginase,liver,ornithine metabolism,urea cycle,cytoplasmic
UniProtKB/Swiss-Prot CatalyticActivity:
L-arginine + H(2)O = L-ornithine + urea.
UniProtKB/Swiss-Prot Induction:
By arginine or homoarginine.

Enzyme Numbers (IUBMB) for ARG1 Gene

Gene Ontology (GO) - Molecular Function for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with ARG1: view
genes like me logo Genes that share phenotypes with ARG1: view

Human Phenotype Ontology for ARG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARG1 Gene

MGI Knock Outs for ARG1:

Animal Model Products

miRNA for ARG1 Gene

miRTarBase miRNAs that target ARG1

No data available for Transcription Factor Targets and HOMER Transcription for ARG1 Gene

Localization for ARG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARG1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARG1 Gene COMPARTMENTS Subcellular localization image for ARG1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 3
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with ARG1: view

Pathways & Interactions for ARG1 Gene

genes like me logo Genes that share pathways with ARG1: view

UniProtKB/Swiss-Prot P05089-ARGI1_HUMAN

  • Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.

Gene Ontology (GO) - Biological Process for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
GO:0001889 liver development IEA --
GO:0006525 arginine metabolic process IEA --
GO:0006595 polyamine metabolic process TAS --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with ARG1: view

No data available for SIGNOR curated interactions for ARG1 Gene

Drugs & Compounds for ARG1 Gene

(29) Drugs for ARG1 Gene - From: Novoseek, DrugBank, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist, Target 63
L-Arginine Approved Nutra Full agonist, Agonist 0
Urea Experimental Pharma Target 0
2(S)-Amino-6-Boronohexanoic Acid Experimental Pharma Target 0
S-2-(Boronoethyl)-L-Cysteine Experimental Pharma Target 0

(11) Additional Compounds for ARG1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ARG1: view

Transcripts for ARG1 Gene

Unigene Clusters for ARG1 Gene

Arginase, liver:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARG1 Gene

No ASD Table

Relevant External Links for ARG1 Gene

GeneLoc Exon Structure for
ARG1
ECgene alternative splicing isoforms for
ARG1

Expression for ARG1 Gene

mRNA expression in normal human tissues for ARG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARG1 Gene

This gene is overexpressed in Liver (x28.1) and Whole Blood (x17.7).

Protein differential expression in normal tissues from HIPED for ARG1 Gene

This gene is overexpressed in Liver, secretome (40.5) and Liver (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARG1 Gene



SOURCE GeneReport for Unigene cluster for ARG1 Gene Hs.440934

genes like me logo Genes that share expression patterns with ARG1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARG1 Gene

Orthologs for ARG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARG1 35
  • 99.38 (n)
  • 99.38 (a)
ARG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARG1 36
  • 91 (a)
OneToOne
ARG1 35
  • 89.34 (n)
  • 90.99 (a)
dog
(Canis familiaris)
Mammalia ARG1 35
  • 90.2 (n)
  • 91.52 (a)
ARG1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arg1 35
  • 83.13 (n)
  • 86.96 (a)
Arg1 16
Arg1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARG1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARG1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arg1 35
  • 82.71 (n)
  • 87.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia arg1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arg1 35
  • 68.8 (n)
  • 71.79 (a)
zebrafish
(Danio rerio)
Actinopterygii arg1 36
  • 57 (a)
OneToMany
ARG1 (1 of 2) 36
  • 57 (a)
OneToMany
arg1 35
  • 64.54 (n)
  • 62.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta arg 36
  • 35 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR225C 35
  • 46.69 (n)
  • 45.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 35
  • 48.22 (n)
  • 43.69 (a)
CAR1 36
  • 40 (a)
OneToMany
CAR1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00704g 35
  • 48.73 (n)
  • 44.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02333 35
  • 50.89 (n)
  • 49.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes car1 35
  • 49.14 (n)
  • 44.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8475 36
  • 42 (a)
OneToMany
Species with no ortholog for ARG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARG1 Gene

ENSEMBL:
Gene Tree for ARG1 (if available)
TreeFam:
Gene Tree for ARG1 (if available)

Paralogs for ARG1 Gene

Paralogs for ARG1 Gene

(1) SIMAP similar genes for ARG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARG1: view

Variants for ARG1 Gene

Sequence variations from dbSNP and Humsavar for ARG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_000674 Argininemia (ARGIN)
VAR_000675 -
rs28941474 Argininemia (ARGIN) 131,573,314(+) GATTA(C/T)TGGAG reference, missense
VAR_015595 Argininemia (ARGIN)
VAR_072164 Argininemia (ARGIN)

Structural Variations from Database of Genomic Variants (DGV) for ARG1 Gene

Variant ID Type Subtype PubMed ID
nsv886668 CNV Gain 21882294

Variation tolerance for ARG1 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARG1 Gene

HapMap Linkage Disequilibrium report
ARG1
Human Gene Mutation Database (HGMD)
ARG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARG1 Gene

Disorders for ARG1 Gene

MalaCards: The human disease database

(24) MalaCards diseases for ARG1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
argininemia
  • hyperargininemia
intestinal schistosomiasis
  • katayama fever
immunodeficiency due to purine nucleoside phosphorylase deficiency
  • purine nucleoside phosphorylase deficiency
blue toe syndrome
muscular dystrophy-dystroglycanopathy , type a, 9
  • muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies a9
- elite association - COSMIC cancer census association via MalaCards
Search ARG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ARGI1_HUMAN
  • Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269 PubMed:1463019, ECO:0000269 PubMed:22959135, ECO:0000269 PubMed:23859858, ECO:0000269 PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for ARG1 Gene

argininemia,with progressive spastic quadriplegia and mental retardation

Relevant External Links for ARG1

Genetic Association Database (GAD)
ARG1
Human Genome Epidemiology (HuGE) Navigator
ARG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARG1
genes like me logo Genes that share disorders with ARG1: view

Publications for ARG1 Gene

  1. Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. (PMID: 22959135) Carvalho D.R. … Pratesi R. (Gene 2012) 2 3 4 67
  2. Arginine availability, arginase, and the immune response. (PMID: 12589193) Bansal V. … Ochoa J.B. (Curr Opin Clin Nutr Metab Care 2003) 23 25 26
  3. Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism. (PMID: 20032293) Yachimovich-Cohen N. … Reubinoff B. (J. Immunol. 2010) 3 23
  4. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. (PMID: 20124949) Vonk J.M. … Meurs H. (Pharmacogenet. Genomics 2010) 3 23
  5. Inhibition of human arginase I by substrate and product analogues. (PMID: 20153713) Di Costanzo L. … Christianson D.W. (Arch. Biochem. Biophys. 2010) 3 23

Products for ARG1 Gene

Sources for ARG1 Gene

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