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ARFRP1 Gene

protein-coding   GIFtS: 57
GCID: GC20M062331

ADP-Ribosylation Factor Related Protein 1

  See ARFRP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor Related Protein 11 2     ADP-Ribosylation Factor-Related Protein 12
ARP2 3 5     Helicase-Like Protein NHL2
ARF-Related Protein 12 3     SCG10 Like-Protein2
ARL182     ARP13
Arp12     

External Ids:    HGNC: 6621   Entrez Gene: 101392   Ensembl: ENSG000001012467   OMIM: 6046995   UniProtKB: Q137953   

Export aliases for ARFRP1 gene to outside databases

Previous GC identifers: GC20M062208 GC20M063010 GC20M063056 GC20M063058 GC20M061800 GC20M059062


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARFRP1 Gene:
The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is
related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane
trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, May 2012)

GeneCards Summary for ARFRP1 Gene:
ARFRP1 (ADP-ribosylation factor related protein 1) is a protein-coding gene. Diseases associated with ARFRP1 include wiskott-aldrich syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL13A.

UniProtKB/Swiss-Prot: ARFRP_HUMAN, Q13795
Function: Possibly involved in plasma membrane-related signaling events

Gene Wiki entry for ARFRP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARFRP1 gene promoter:
         ATF-2   MEF-2   MEF-2A   CRE-BP1   HEN1   COMP1   HSF1short   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARFRP1 promoter sequence
   Search Chromatin IP Primers for ARFRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARFRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

ARFRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFRP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062331:  view genomic region     (about GC identifiers)

Start:
62,329,995 bp from pter      End:
62,339,377 bp from pter
Size:
9,383 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARFRP_HUMAN, Q13795 (See protein sequence)
Recommended Name: ADP-ribosylation factor-related protein 1  
Size: 201 amino acids; 22614 Da
Subunit: Interacts with SYS1
Secondary accessions: B7ZKX7 E1P5J9 Q6IBQ0
Alternative splicing: 2 isoforms:  Q13795-1   Q13795-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARFRP1: NX_Q13795

Explore proteomics data for ARFRP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys174

  • See ARFRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001128230.1  NP_001254473.1  NP_001254474.1  NP_001254475.1  NP_001254476.1  NP_001254477.1  NP_001254478.1  NP_003215.1  

    ENSEMBL proteins: 
     ENSP00000352746   ENSP00000217224   ENSP00000326884   ENSP00000476470   ENSP00000477237  
     ENSP00000476756   ENSP00000403942  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARF: ADP-ribosylation factors

    5 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q13795

    ProtoNet protein and cluster: Q13795

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARFRP_HUMAN, Q13795
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARFRP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARFRP_HUMAN, Q13795
    Function: Possibly involved in plasma membrane-related signaling events

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8530503
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI11438518
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    Find genes that share ontologies with ARFRP1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arfrp1):
     cellular  embryogenesis  mortality/aging 

    Find genes that share phenotypes with ARFRP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arfrp1tm1Asch for ARFRP1

       genOway: Develop your customized and physiologically relevant rodent model for ARFRP1

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    miRTarBase miRNAs that target ARFRP1:
    hsa-mir-26b-5p (MIRT029524)

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    hsa-miR-511 hsa-miR-361-3p hsa-miR-561
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARFRP_HUMAN, Q13795: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IDA16129887

    Find genes that share ontologies with ARFRP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARFRP1
    Interactions:

        GeneGlobe Interaction Network for ARFRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARFRP1 (Q137953 ENSP000003268844) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH1Q154383, ENSP000003543984I2D: score=3 STRING: ENSP00000354398
    EIF3BP558843, ENSP000003541254I2D: score=3 STRING: ENSP00000354125
    AP3D1O146173, ENSP000003440554I2D: score=1 STRING: ENSP00000344055
    AP3S1Q925723, ENSP000003253694I2D: score=1 STRING: ENSP00000325369
    ARFGAP1Q8N6T33, ENSP000003146154I2D: score=1 STRING: ENSP00000314615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8530503
    GO:0006886intracellular protein transport ----
    GO:0007165signal transduction TAS8530503
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with ARFRP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ARFRP1 (ARFRP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARFRP1 gene (8 alternative transcripts): 
    NM_001134758.3  NM_001267544.2  NM_001267545.2  NM_001267546.2  NM_001267547.2  NM_001267548.2  NM_001267549.2  NM_003224.5  

    Unigene Cluster for ARFRP1:

    ADP-ribosylation factor related protein 1
    Hs.389277  [show with all ESTs]
    Unigene Representative Sequence: AK095962
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359715(uc002yga.3) ENST00000485858 ENST00000217224 ENST00000324228
    ENST00000609142 ENST00000610136 ENST00000609243 ENST00000609188 ENST00000607873
    ENST00000609537 ENST00000424545 ENST00000440854(uc002ygc.3 uc011abg.2 uc011abh.2 uc002ygf.3 uc011abf.2 uc002ygh.4)

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    hsa-miR-511 hsa-miR-361-3p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidARFRP1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK095962.1 BC021023.1 BC092480.1 BC093967.1 BC143447.1 BC143448.1 BC143467.1 BC143472.1 
    BC143477.1 BT019624.1 BT019663.1 CR456752.1 NR_051954.1 NR_051955.1 NR_051956.1 NR_051957.1 
    NR_051958.1 X91504.1 

    21 DOTS entries:

    DT.100809266  DT.100718428  DT.216485  DT.100746777  DT.92435431  DT.100809281  DT.95255133  DT.100809284 
    DT.100862137  DT.100809285  DT.109754  DT.97763700  DT.100809283  DT.100746778  DT.100809272  DT.40114701 
    DT.100836134  DT.100845109  DT.92435432  DT.95255114  DT.95255137 

    Selected AceView cDNA sequences (see all 322):

    BX447173 BE645769 NM_003224 CR602845 BM770791 CR623922 BI824742 BQ073457 
    BQ581568 CR613687 BC021023 AI571407 CR590403 AI356594 BF435047 CR626804 
    AI968764 CA405823 CA434493 AL533893 AI674255 CK902106 BX363231 CR614799 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARFRP1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
    SP1:                                            -     -           -                       -     -                 -     -                                       
    SP2:                                            -     -           -                       -     -                 -     -                                       
    SP3:                                                  -           -                       -     -                 -     -                                       
    SP4:                                            -     -     -     -                       -     -                 -     -                                       
    SP5:                                            -     -           -                       -     -                 -     -                                       

    ExUns: 11f · 11g · 11h · 11i
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ARFRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARFRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCAAAGG
    ARFRP1 Expression
    About this image


    ARFRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Lymph (Hematopoietic System)
    ARFRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARFRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389277

    UniProtKB/Swiss-Prot: ARFRP_HUMAN, Q13795
    Tissue specificity: Found in most tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARFRP1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arfrp11 , 5 ADP-ribosylation factor related protein 11, 5 88.56(n)1
    97.01(a)1
      2 (103.63 cM)5
    766881  NM_001165992.11  NP_001159464.11 
     1813578295 
    chicken
    (Gallus gallus)
    Aves ARFRP11 ADP-ribosylation factor related protein 1 78.11(n)
    91.04(a)
      419261  XM_417433.4  XP_417433.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARFRP16
    ADP-ribosylation factor related protein 1
    90(a)
    1 ↔ 1
    GL343401.1(902361-917580)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg7039-prov2 hypothetical protein MGC64400 79.6(n)    BC054219.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arfrp11 ADP-ribosylation factor related protein 1 78.23(n)
    87.86(a)
      503602  NM_001013289.2  NP_001013307.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70391 , 3 ARF small monomeric GTPase3
    CG70391
    63(a)3
    66.67(n)1
    63.82(a)1
      8C93
    318411  NM_132298.41  NP_572526.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.23
    CELE_Y54E10BR.21
    CELE_Y54E10BR.21 40(a)3
    49.82(n)1
    40.22(a)1
      I(3033007-3033825)3
    1718781  NM_058693.51  NP_491094.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARL3(YPL051W)4
    ARL31
    GTPase of the Ras superfamily required to recruit Arl1p more4
    ARL31
    49.4(n)1
    49.22(a)1
      16(459963-460559)4
    8560561, 4  NP_015274.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GB11 GB1 49.38(n)
    44.92(a)
      835297  NM_124600.2  NP_200034.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03923001 Os03g0392300 51.52(n)
    44.39(a)
      4333026  NM_001056818.1  NP_001050283.1 


    ENSEMBL Gene Tree for ARFRP1 (if available)
    TreeFam Gene Tree for ARFRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARFRP1 gene
    ARL13A2  ARL13B2  
    Selected SIMAP similar genes for ARFRP1 using alignment to 6 protein entries:     ARFRP_HUMAN (see all proteins) (see all similar genes):
    ARL5A    ARL2    ARL5B    ARF1    ARL14    ARF6
    ARF5    ARF4    ARL6    TRIM23    ARF3    ARL1
    ARL3    ARL4A    ARL5C    SAR1B    ARL8B    ARL13B

    Find genes that share paralogs with ARFRP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARFRP1 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365594
    A breast cancer sample4--see VAR_0365592 L V mis40--------
    rs1875794211,2
    --59073834(+) TTTTTG/TGAGAT 1 -- us2k10--------
    rs48093251,2
    C,A,H--59073839(+) tgagaC/Tggagt 1 -- us2k18Minor allele frequency- T:0.00NA WA CSA 16
    rs1909359891,2
    --59073847(+) AGTCTC/TGTTCT 1 -- us2k10--------
    rs1833912271,2
    --59073849(+) TCTTGC/TTCTGT 1 -- us2k10--------
    rs1866359031,2
    --59073855(+) TCTGTA/TGCCCA 1 -- us2k10--------
    rs1926908281,2
    C--59073902(+) AGCTCC/TGCCTC 1 -- us2k10--------
    rs1845431541,2
    --59074007(+) GAGACA/GGGGTT 13 -- us2k10--------
    rs1881818691,2
    --59074170(+) AGTGGC/TGCAAT 13 -- us2k10--------
    rs778296601,2
    C--59074233(+) CCTCCC/TGAGTA 12 -- us2k11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for ARFRP1 (62329995 - 62339377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARFRP1 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913250CNV Loss21882294
    dgv4647n71CNV Loss21882294
    dgv4644n71CNV Loss21882294
    dgv4645n71CNV Loss21882294
    nsv913213CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv828801CNV Loss20364138
    dgv4646n71CNV Loss21882294
    nsv470563CNV Loss18288195
    nsv913190CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARFRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARFRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604699    OMIM disorders: --

    1 disease for ARFRP1:    
    About MalaCards
    wiskott-aldrich syndrome

    1 disease from the University of Copenhagen DISEASES database for ARFRP1:
    Otosclerosis

    Find genes that share disorders with ARFRP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for ARFRP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 65 1 15834156 (1)

    Genetic Association Database (GAD): ARFRP1

    Export disorders for ARFRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARFRP1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ARFRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors. (PubMed id 8530503)1, 2, 3 Schuermann A.... Joost H.-G. (J. Biol. Chem. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N- terminal acetylation and the membrane protein Sys1p. (PubMed id 15077113)1, 2 Behnia R.... Munro S. (Nat. Cell Biol. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)1, 2 Bai C.... Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)
    7. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. (PubMed id 22505585)1 Jaschke A....SchA1rmann A. (Hum. Mol. Genet. 2012)
    10. Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. (PubMed id 19224922)1 Nishimoto-Morita K....Nakayama K. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10139 HGNC: 662 AceView: ARFRP1 Ensembl:ENSG00000101246 euGenes: HUgn10139
    ECgene: ARFRP1 H-InvDB: ARFRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARFRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARFRP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARFRP1 gene:
    Search GeneIP for patents involving ARFRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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