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Aliases for ARFIP2 Gene

Aliases for ARFIP2 Gene

  • ADP Ribosylation Factor Interacting Protein 2 2 3 5
  • POR1 3 4
  • ADP-Ribosylation Factor-Interacting Protein 2 4
  • Partner Of RAC1 (Arfaptin 2) 3
  • Partner Of RAC1 4
  • Protein POR1 4
  • Arfaptin 2 2
  • Arfaptin-2 3

External Ids for ARFIP2 Gene

Previous GeneCards Identifiers for ARFIP2 Gene

  • GC11M006455
  • GC11M006461
  • GC11M006453
  • GC11M006156

Summaries for ARFIP2 Gene

GeneCards Summary for ARFIP2 Gene

ARFIP2 (ADP Ribosylation Factor Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling_Role of PDGFs in cell migration and Vesicle-mediated transport. GO annotations related to this gene include GTP binding and Rac GTPase binding. An important paralog of this gene is ARFIP1.

UniProtKB/Swiss-Prot for ARFIP2 Gene

  • Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Wiki entry for ARFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP2 Gene

Genomics for ARFIP2 Gene

Regulatory Elements for ARFIP2 Gene

Enhancers for ARFIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F006458 1.1 ENCODE 11.5 +21.9 21943 2.4 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SP3 SP5 TIMM10B PRKCDBP ARFIP2 DNHD1 APBB1 SMPD1 GC11P006457 GC11M006470
GH11F006400 1.1 Ensembl ENCODE 10.2 +78.1 78110 5.5 SOX13 USF1 TBL1XR1 TEAD4 ZBTB40 ZNF766 POLR2A SCRT2 EED ETV6 SMPD1 HPX ARFIP2 TIMM10B PRKCDBP APBB1 GC11P006400 PIR40798
GH11F006693 1.1 Ensembl ENCODE 10.1 -213.5 -213521 3.3 HDAC1 PKNOX1 PTRF ZNF121 NR2F2 CREB3 TFDP1 ZFP69B MEF2D ZNF589 GVINP2 OR2AG2 ILK RRP8 TIMM10B ENSG00000254400 ENSG00000254641 TAF10 ARFIP2 APBB1
GH11F006228 1.1 Ensembl ENCODE 10.1 +251.5 251542 2.8 RAD21 YY1 ZNF335 ZNF766 GATA2 FOS ZNF654 ZBTB11 USF2 ZEB2 CCKBR TIMM10B FAM160A2 ARFIP2 C11orf42
GH11F006443 0.9 Ensembl ENCODE 10.6 +38.0 38039 0.5 CTCF ZFP64 TRIM22 REST RAD21 YY1 ZNF274 JUND KLF16 ZNF143 APBB1 SMPD1 ARFIP2 TIMM10B HPX GC11P006457
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARFIP2 on UCSC Golden Path with GeneCards custom track

Promoters for ARFIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107625 -21 1801 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SP3

Genomic Location for ARFIP2 Gene

Chromosome:
11
Start:
6,474,683 bp from pter
End:
6,481,479 bp from pter
Size:
6,797 bases
Orientation:
Minus strand

Genomic View for ARFIP2 Gene

Genes around ARFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP2 Gene

Proteins for ARFIP2 Gene

  • Protein details for ARFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53365-ARFP2_HUMAN
    Recommended name:
    Arfaptin-2
    Protein Accession:
    P53365
    Secondary Accessions:
    • B4DX86
    • B4E306
    • D3DQT5

    Protein attributes for ARFIP2 Gene

    Size:
    341 amino acids
    Molecular mass:
    37856 Da
    Quaternary structure:
    • Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level.

    Three dimensional structures from OCA and Proteopedia for ARFIP2 Gene

    Alternative splice isoforms for ARFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFIP2 Gene

Post-translational modifications for ARFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARFIP2 Gene

Domains & Families for ARFIP2 Gene

Gene Families for ARFIP2 Gene

Protein Domains for ARFIP2 Gene

Suggested Antigen Peptide Sequences for ARFIP2 Gene

Graphical View of Domain Structure for InterPro Entry

P53365

UniProtKB/Swiss-Prot:

ARFP2_HUMAN :
  • Contains 1 AH domain.
Domain:
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ARFIP2: view

Function for ARFIP2 Gene

Molecular function for ARFIP2 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Ontology (GO) - Molecular Function for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8670882
GO:0005525 GTP binding TAS 8670882
GO:0019904 protein domain specific binding IEA --
GO:0030742 GTP-dependent protein binding TAS 9312003
GO:0042802 identical protein binding IPI 8670882
genes like me logo Genes that share ontologies with ARFIP2: view
genes like me logo Genes that share phenotypes with ARFIP2: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP2 Gene

Localization for ARFIP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARFIP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IMP 8670882
GO:0005737 cytoplasm TAS 9312003
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 9312003
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with ARFIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP2 Gene

Pathways & Interactions for ARFIP2 Gene

genes like me logo Genes that share pathways with ARFIP2: view

SIGNOR curated interactions for ARFIP2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 8670882
GO:0007264 small GTPase mediated signal transduction TAS 8670882
GO:0030032 lamellipodium assembly TAS 9312003
GO:0030036 actin cytoskeleton organization IMP 9312003
GO:0031529 ruffle organization TAS 9312003
genes like me logo Genes that share ontologies with ARFIP2: view

Drugs & Compounds for ARFIP2 Gene

(1) Drugs for ARFIP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for ARFIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARFIP2: view

Transcripts for ARFIP2 Gene

Unigene Clusters for ARFIP2 Gene

ADP-ribosylation factor interacting protein 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7a · 7b · 7c ^ 8a · 8b ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - -
SP18: - -
SP19: -
SP20:
SP21: - -
SP22: - - -
SP23: -
SP24: - - - - - - - -
SP25:

ExUns: 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for ARFIP2 Gene

GeneLoc Exon Structure for
ARFIP2
ECgene alternative splicing isoforms for
ARFIP2

Expression for ARFIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARFIP2 Gene

Protein differential expression in normal tissues from HIPED for ARFIP2 Gene

This gene is overexpressed in Nasal epithelium (13.4), Skin (12.3), Brain (10.5), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARFIP2 Gene



Protein tissue co-expression partners for ARFIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARFIP2 Gene:

ARFIP2

SOURCE GeneReport for Unigene cluster for ARFIP2 Gene:

Hs.75139
genes like me logo Genes that share expression patterns with ARFIP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARFIP2 Gene

Orthologs for ARFIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFIP2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ARFIP2 34 35
  • 96.68 (n)
cow
(Bos Taurus)
Mammalia ARFIP2 34 35
  • 95.5 (n)
oppossum
(Monodelphis domestica)
Mammalia ARFIP2 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfip2 34 16 35
  • 94.43 (n)
rat
(Rattus norvegicus)
Mammalia Arfip2 34
  • 93.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARFIP2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARFIP2 34 35
  • 76.59 (n)
lizard
(Anolis carolinensis)
Reptilia ARFIP2 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arfip2b 34 35
  • 71.03 (n)
arfip2a 35
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17184 34 35
  • 59.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004910 34
  • 55.92 (n)
worm
(Caenorhabditis elegans)
Secernentea F54C8.7 34 35
  • 45.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 35
  • 60 (a)
OneToMany
Species where no ortholog for ARFIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARFIP2 Gene

ENSEMBL:
Gene Tree for ARFIP2 (if available)
TreeFam:
Gene Tree for ARFIP2 (if available)

Paralogs for ARFIP2 Gene

Paralogs for ARFIP2 Gene

(1) SIMAP similar genes for ARFIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARFIP2: view

Variants for ARFIP2 Gene

Sequence variations from dbSNP and Humsavar for ARFIP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10136 -- 6,482,966(-) TCCAG(A/C)CTTCT upstream-variant-2KB, utr-variant-3-prime
rs1048121 -- 6,482,345(+) TCCTT(A/G)CTCCT upstream-variant-2KB, utr-variant-3-prime
rs1063250 -- 6,483,294(+) GTCCC(A/C)TTGAG upstream-variant-2KB, utr-variant-3-prime
rs111295668 -- 6,477,715(+) GTTGG(C/G)ACCTT intron-variant, nc-transcript-variant
rs111604826 -- 6,475,766(+) AGCTC(C/T)GCCTC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARFIP2 Gene

Variant ID Type Subtype PubMed ID
nsv972944 CNV duplication 23825009
esv3625266 CNV gain 21293372

Variation tolerance for ARFIP2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP2 Gene

Disorders for ARFIP2 Gene

Relevant External Links for ARFIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFIP2

No disorders were found for ARFIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP2 Gene

Publications for ARFIP2 Gene

  1. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H. … Exton J.H. (J. Biol. Chem. 1997) 2 3 4 64
  2. Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PMID: 8670882) van Aelst L. … Bar-Sagi D. (EMBO J. 1996) 2 3 4 64
  3. Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PMID: 15809304) Rangone H. … Humbert S. (J. Biol. Chem. 2005) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. (PMID: 11346801) Tarricone C. … Smerdon S.J. (Nature 2001) 3 4 64

Products for ARFIP2 Gene

Sources for ARFIP2 Gene

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