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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARFIP2 Gene

protein-coding GIFtS: 60
GCID: GC11M006496

ADP-ribosylation factor interacting protein 2

Explore 1 disease affiliated with
ARFIP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor Interacting Protein 2¹ ²		ADP-Ribosylation Factor-Interacting Protein 2³
POR1¹ ² ³		Partner Of RAC1³
Arfaptin-2¹		Protein POR1³
Partner Of RAC1 (Arfaptin 2)²

External Ids:	HGNC: 17160¹	Entrez Gene: 23647²	Ensembl: ENSG00000132254⁷	OMIM: 601638⁵	UniProtKB: P53365³

Export aliases for ARFIP2 gene to outside databases

Previous GC identifers: GC11M006455 GC11M006461 GC11M006453 GC11M006156

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365

Function: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling

Gene Wiki entry for ARFIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARFIP2 gene promoter:
GR AREB6 Egr-2 PPAR-gamma1 PPAR-gamma2 GR-alpha TGIF Pax-4a ATF Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARFIP2 promoter sequence

Search SABiosciences Chromatin IP Primers for ARFIP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARFIP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15

ARFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFIP2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M006496: view genomic region (about GC identifiers)

Start:	6,496,910 bp from pter	End:	6,502,666 bp from pter
Size:	5,757 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365 (See protein sequence)

Recommended Name: Arfaptin-2

Size: 341 amino acids; 37856 Da

Subunit: Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to

RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to

a > 4-fold increase in the amount of ARL1-bound GTP at steady state level

5 PDB 3D structures from and Proteopedia for ARFIP2:

1I49 (3D)

1I4D (3D)

1I4L (3D)

1I4T (3D)

4DCN (3D)

Secondary accessions: B4E306 D3DQT5

Alternative splicing: 2 isoforms: P53365-1 P53365-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARFIP2: NX_P53365

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53365

ARFIP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001229783.1 NP_001229784.1 NP_001229785.1 NP_036534.1

ENSEMBL proteins:

ENSP00000254584 ENSP00000379998 ENSP00000434564 ENSP00000434124 ENSP00000398375

ENSP00000391427

Human Recombinant Protein Products for ARFIP2:

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	Novus Biologicals ARFIP2 Proteins Novus Biologicals ARFIP2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ARFIP2
	Uscn Proteins for ARFIP2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IMP	8670882
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	TAS	9312003
GO:0005886	plasma membrane	TAS	9312003
GO:0005938	cell cortex	IDA	9312003

ARFIP2 for ontologies About GeneDecksing

ARFIP2 Antibody Products:

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	Uscn ELISAs and CLIAs for ARFIP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARFIP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR010504 AH_dom

Graphical View of Domain Structure for InterPro Entry P53365

ProtoNet protein and cluster: P53365

1 Blocks protein family: IPB010504 Arfaptin-like

UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365

Similarity: Contains 1 AH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ARFP2_HUMAN, P53365

Function: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	TAS	8670882
GO:0019904	protein domain specific binding	IEA	--
GO:0030742	GTP-dependent protein binding	TAS	9312003
GO:0048365	Rac GTPase binding	TAS	9312003

ARFIP2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ARFIP2:

Decreased POU5F1-GFP protein e

Decreased circadian period len

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARFIP2

miRNA Products:		miRTarBase miRNAs that target ARFIP2: hsa-mir-155 (MIRT001570)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARFIP2
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate ARFIP2 (see all 52):
		hsa-miR-140-5p hsa-miR-582-3p hsa-miR-520f hsa-miR-328 hsa-miR-488 hsa-miR-192 hsa-miR-4267 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: ARFIP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARFIP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARFIP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFIP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_RAC1 in cellular process

G-protein signaling RAC1 in cellular process

1.00

G-protein signaling_RAC1 in cellular process

1.00

Development HGF signaling pathway

Cytoskeleton remodeling_Role of PDGFs in cell migration

0.11

Cytoskeleton remodeling Role of PDGFs in cell migration

0.11

Rho Family GTPases

Rho Family GTPases

1.00

Arf1 pathway

Arf1 pathway

1.00

Apoptotic Pathways in Synovial Fibroblasts

Rac1 Pathway

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ARFIP2

	G-protein signaling RAC1 in cellular process
	Cytoskeleton remodeling Role of PDGFs in cell migration

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARFIP2

	Rac1 Pathway
	Paxillin Interactions
	Huntington's Disease Pathway
	PDGF Pathway
	Rho Family GTPases

2 GeneGo (Thomson Reuters) Pathways for ARFIP2

	Cytoskeleton remodeling Role of PDGFs in cell migration
	G-protein signaling RAC1 in cellular process

1 BioSystems Pathway for ARFIP2

Arf1 pathway

ARFIP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARFIP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/20 Interacting proteins for ARFIP2 (P53365^{1, 2, 3} ENSP00000254584⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DTNBP1	Q96EV8²^,³, ENSP00000341680⁴	MINT-66731 I2D: score=5 STRING: ENSP00000341680
ITGB3BP	Q13352²^,³, ENSP00000271002⁴	MINT-68205 I2D: score=5 STRING: ENSP00000271002
RAC1	P63000¹^,³, ENSP00000348461⁴	EBI-638194,EBI-413628 I2D: score=5 STRING: ENSP00000348461
ARF6	P62330¹^,³, ENSP00000298316⁴	EBI-638194,EBI-2802827 I2D: score=4 STRING: ENSP00000298316
RAC2	P15153³, ENSP00000249071⁴	I2D: score=3 STRING: ENSP00000249071

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	8670882
GO:0007264	small GTPase mediated signal transduction	TAS	8670882
GO:0030032	lamellipodium assembly	TAS	9312003
GO:0030036	actin cytoskeleton organization	IMP	9312003
GO:0031529	ruffle organization	TAS	9312003

ARFIP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ARFIP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARFIP2

1 HMDB Compound for ARFIP2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for ARFIP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	44.4	1	9312003 (1)

Search CenterWatch for drugs/clinical trials and news about ARFIP2 / ARFP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARFIP2 gene (4 alternative transcripts):

NM_001242854.1 NM_001242855.1 NM_001242856.1 NM_012402.3

Unigene Cluster for ARFIP2:

ADP-ribosylation factor interacting protein 2

Hs.75139 [show with all ESTs]

Unigene Representative Sequence: NM_001242854

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000254584(uc001mdk.3 uc010ran.2 uc010ral.2 uc010ram.2)

ENST00000396777 ENST00000531037 ENST00000525235 ENST00000528892(uc009yfe.2)

ENST00000530410 ENST00000529847 ENST00000525329 ENST00000423813 ENST00000445086

miRNA Products:		OriGene 3'-UTR Clone: ARFIP2 Browse OriGene MicroRNA Expression Plasmids
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		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate ARFIP2 (see all 52):
		hsa-miR-140-5p hsa-miR-582-3p hsa-miR-520f hsa-miR-328 hsa-miR-488 hsa-miR-192 hsa-miR-4267 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: ARFIP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK026390.1 AK300855.1 AK301856.1 AK301972.1 AK304512.1 AK310267.1 AK311004.1 BC000392.2

U52522.1 X97567.1

24/25 DOTS entries (see all 25):

DT.317682 DT.95260055 DT.100037134 DT.100864420 DT.95260059 DT.95260067 DT.101959902 DT.120709587

DT.120709362 DT.120709466 DT.120709440 DT.95260069 DT.97762248 DT.100658806 DT.120709477 DT.75158730

DT.120709519 DT.120709318 DT.120709501 DT.100639536 DT.100731839 DT.100848581 DT.95152152 DT.95260054

24/436 AceView cDNA sequences (see all 436):

BQ108558 BQ219311 AI673192 BQ057966 CR606576 BE464811 BU740689 AA496338

BX378226 AA769484 W44387 AA425908 AW612115 BQ883020 BI255531 CB163549

AI368743 BQ066356 F10270 BE795243 BM852888 CA488547 CA455158 BE274809

GeneLoc Exon Structure

5/25 Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP2 (see all 25) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	·	6h	^	7a	·	7b	·	7c	^	8a	·	8b	^
SP1:											-		-		-				-						-		-		-		-										-				-		-		-		-
SP2:											-		-		-				-						-		-		-		-										-										-
SP3:											-		-						-						-		-		-		-										-										-
SP4:											-		-		-				-						-		-		-		-										-										-
SP5:											-		-						-						-		-		-		-										-										-

ExUns:	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	·	11d	·	11e	·	11f	·	11g	^	12a	·	12b	·	12c	·	12d
SP1:	-																				-
SP2:	-																				-
SP3:	-
SP4:	-
SP5:

ECgene alternative splicing isoforms for ARFIP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARFIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACATCCTT

About this image
See ARFIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARFIP2

SOURCE GeneReport for Unigene cluster: Hs.75139
SABiosciences Expression via Pathway-Focused PCR Arrays including ARFIP2:

Cytoskeleton Regulators in human mouse rat

Huntington's Disease in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARFIP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFIP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARFIP2 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARFIP2¹	ADP-ribosylation factor interacting protein 2 (arfaptin more	79.55(n) 85.17(a)		419075 XM_417266.3 XP_417266.3
lizard (Anolis carolinensis)	Reptilia	ARFIP2⁶	--	82(a)	1 ↔ 1	GL343952.1(85984-102530)
zebrafish (Danio rerio)	Actinopterygii	arfip2b¹	ADP-ribosylation factor interacting protein 2b	71.03(n) 77.03(a)		550342 NM_001017649.1 NP_001017649.1
fruit fly (Drosophila melanogaster)	Insecta	CG17184¹	CG17184	55.42(n) 51.37(a)		41353 NM_141801.2 NP_650058.1
worm (Caenorhabditis elegans)	Secernentea	F54C8.7¹	Protein F54C8.7	45.24(n) 32.35(a)		176326 NM_181932.3 NP_871661.1

ENSEMBL Gene Tree for ARFIP2 (if available)
TreeFam Gene Tree for ARFIP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARFIP2 gene

ARFIP1²

1 SIMAP similar gene for ARFIP2 using alignment to 3 protein entries: ARFP2_HUMAN (see all proteins):

ARFIP1

ARFIP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143046079^1,2		--	6497858(+)	`GGCCAA/GCAATG`	4	--	ut3¹		0	--	--	--	--
rs1802921^1,2	C,F	--	6497884(-)	`AAAGGG/TGTGGG`	4	--	ut3¹		1		WA	118
rs147006416^1,2		--	6497909(+)	`TCTCTA/GCAATG`	4	--	ut3¹		0	--	--	--	--
rs114586125^1,2	C,F	--	6497975(+)	`AGTCCG/AAGAAG`	4	--	ut3¹		1		WA	118
rs3741269^1,2		--	6498019(+)	`CTGTCA/GTTGGT`	4	--	ut3¹ ese³		0	--	--	--	--
rs76849400^1,2	C,F	--	6498174(+)	`CCAGGC/TCCTCT`	4	--	ut3¹		1		WA	118
rs113087339^1,2	C	--	6498175(+)	`CAGGCA/C/GCTCTT`	8	--	ut3¹		1		CSA	1
rs141798060^1,2	C	--	6498464(+)	`CATTGC/TGGAAG`	8	H R	mis¹		0	--	--	--	--
rs113331104^1,2	C	--	6498675(+)	`AGAAAA/CCTCAC`	4	--	int¹		0	--	--	--	--
rs150552590^1,2		--	6498732(+)	`TTTTCC/TCAGTT`	4	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARFIP2 (6496910 - 6502666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARFIP2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARFIP2 for disorders           About GeneDecksing

OMIM gene information: 601638    OMIM disorders: --

1 disease for ARFIP2:    About MalaCards

huntington's disease

Export disorders for ARFIP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ARFIP2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with ARFIP2)

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Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PubMed id 9038142)^{1, 2, 3} Kanoh H.... Exton J.H. (1997)
Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PubMed id 8670882)^{1, 2, 3} van Aelst L.... Bar-Sagi D. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. (PubMed id 11346801)^{1, 2} Tarricone C.... Smerdon S.J. (2001)
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PubMed id 15809304)^{1, 9} Rangone H....Humbert S. (2005)
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. (PubMed id 9312003)^{1, 9} D'Souza-Schorey C....Van Aelst L. (1997)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
Structural basis for membrane binding specificity of t he Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. (PubMed id 22679020)¹ Nakamura K....Wakatsuki S. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23647	HGNC: 17160	AceView: ARFIP2	Ensembl:ENSG00000132254	euGenes: HUgn23647
ECgene: ARFIP2	H-InvDB: ARFIP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARFIP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ARFIP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ARFIP2 gene
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Patent Information for ARFIP2 gene:
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ADP-ribosylation factor interacting protein 2

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ADP-ribosylation factor interacting protein 2

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