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Aliases for ARFIP2 Gene

Aliases for ARFIP2 Gene

  • ADP Ribosylation Factor Interacting Protein 2 2 3 5
  • POR1 3 4
  • ADP-Ribosylation Factor-Interacting Protein 2 4
  • Partner Of RAC1 (Arfaptin 2) 3
  • Partner Of RAC1 4
  • Protein POR1 4
  • Arfaptin 2 2

External Ids for ARFIP2 Gene

Previous GeneCards Identifiers for ARFIP2 Gene

  • GC11M006455
  • GC11M006461
  • GC11M006453
  • GC11M006156

Summaries for ARFIP2 Gene

GeneCards Summary for ARFIP2 Gene

ARFIP2 (ADP Ribosylation Factor Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include GTP binding and Rac GTPase binding. An important paralog of this gene is ARFIP1.

UniProtKB/Swiss-Prot for ARFIP2 Gene

  • Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Wiki entry for ARFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP2 Gene

Genomics for ARFIP2 Gene

Regulatory Elements for ARFIP2 Gene

Promoters for ARFIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARFIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARFIP2 Gene

Chromosome:
11
Start:
6,474,683 bp from pter
End:
6,481,479 bp from pter
Size:
6,797 bases
Orientation:
Minus strand

Genomic View for ARFIP2 Gene

Genes around ARFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP2 Gene

Proteins for ARFIP2 Gene

  • Protein details for ARFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53365-ARFP2_HUMAN
    Recommended name:
    Arfaptin-2
    Protein Accession:
    P53365
    Secondary Accessions:
    • B4DX86
    • B4E306
    • D3DQT5

    Protein attributes for ARFIP2 Gene

    Size:
    341 amino acids
    Molecular mass:
    37856 Da
    Quaternary structure:
    • Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level.

    Three dimensional structures from OCA and Proteopedia for ARFIP2 Gene

    Alternative splice isoforms for ARFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFIP2 Gene

Proteomics data for ARFIP2 Gene at MOPED

Post-translational modifications for ARFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ARFIP2 Gene

Domains & Families for ARFIP2 Gene

Protein Domains for ARFIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARFIP2 Gene

Graphical View of Domain Structure for InterPro Entry

P53365

UniProtKB/Swiss-Prot:

ARFP2_HUMAN :
  • Contains 1 AH domain.
Domain:
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ARFIP2: view

No data available for Gene Families for ARFIP2 Gene

Function for ARFIP2 Gene

Molecular function for ARFIP2 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Ontology (GO) - Molecular Function for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 8670882
GO:0005525 GTP binding TAS 8670882
GO:0070273 phosphatidylinositol-4-phosphate binding IDA 23695357
genes like me logo Genes that share ontologies with ARFIP2: view
genes like me logo Genes that share phenotypes with ARFIP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP2 Gene

Localization for ARFIP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARFIP2 Gene COMPARTMENTS Subcellular localization image for ARFIP2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9312003
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARFIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP2 Gene

Pathways & Interactions for ARFIP2 Gene

genes like me logo Genes that share pathways with ARFIP2: view

SIGNOR curated interactions for ARFIP2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030032 lamellipodium assembly TAS 9312003
GO:0030036 actin cytoskeleton organization IMP 9312003
genes like me logo Genes that share ontologies with ARFIP2: view

Drugs & Compounds for ARFIP2 Gene

(1) Drugs for ARFIP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for ARFIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARFIP2: view

Transcripts for ARFIP2 Gene

Unigene Clusters for ARFIP2 Gene

ADP-ribosylation factor interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7a · 7b · 7c ^ 8a · 8b ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - -
SP18: - -
SP19: -
SP20:
SP21: - -
SP22: - - -
SP23: -
SP24: - - - - - - - -
SP25:

ExUns: 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for ARFIP2 Gene

GeneLoc Exon Structure for
ARFIP2
ECgene alternative splicing isoforms for
ARFIP2

Expression for ARFIP2 Gene

mRNA expression in normal human tissues for ARFIP2 Gene

Protein differential expression in normal tissues from HIPED for ARFIP2 Gene

This gene is overexpressed in Nasal epithelium (13.4), Skin (12.3), Brain (10.5), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFIP2 Gene



SOURCE GeneReport for Unigene cluster for ARFIP2 Gene Hs.75139

genes like me logo Genes that share expression patterns with ARFIP2: view

Protein tissue co-expression partners for ARFIP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARFIP2 Gene

Orthologs for ARFIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFIP2 36
  • 99 (a)
OneToOne
ARFIP2 35
  • 99.55 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia ARFIP2 35
  • 95.5 (n)
  • 99.12 (a)
ARFIP2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARFIP2 36
  • 99 (a)
OneToOne
ARFIP2 35
  • 96.68 (n)
  • 99.41 (a)
mouse
(Mus musculus)
Mammalia Arfip2 16
Arfip2 36
  • 99 (a)
OneToOne
Arfip2 35
  • 94.43 (n)
  • 99.12 (a)
oppossum
(Monodelphis domestica)
Mammalia ARFIP2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARFIP2 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arfip2 35
  • 93.84 (n)
  • 99.12 (a)
chicken
(Gallus gallus)
Aves ARFIP2 35
  • 76.59 (n)
  • 81.69 (a)
ARFIP2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARFIP2 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arfip2b 35
  • 71.03 (n)
  • 77.03 (a)
arfip2a 36
  • 64 (a)
OneToMany
arfip2b 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004910 35
  • 55.92 (n)
  • 56.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17184 35
  • 59.3 (n)
  • 56.93 (a)
CG17184 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F54C8.7 36
  • 30 (a)
OneToMany
F54C8.7 35
  • 45.4 (n)
  • 32.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 36
  • 60 (a)
OneToMany
Species with no ortholog for ARFIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARFIP2 Gene

ENSEMBL:
Gene Tree for ARFIP2 (if available)
TreeFam:
Gene Tree for ARFIP2 (if available)

Paralogs for ARFIP2 Gene

Paralogs for ARFIP2 Gene

(1) SIMAP similar genes for ARFIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARFIP2: view

Variants for ARFIP2 Gene

Sequence variations from dbSNP and Humsavar for ARFIP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1802921 -- 6,476,654(-) AAAGG(G/T)GTGGG utr-variant-3-prime
rs1802922 -- 6,476,641(-) TAATG(A/G)GGAGC utr-variant-3-prime
rs1802923 -- 6,476,696(-) TCTCC(C/T)CTATG downstream-variant-500B, utr-variant-3-prime
rs2253104 -- 6,479,079(-) TTTTC(C/T)TCGTG intron-variant
rs2303493 -- 6,477,985(-) GAAAT(C/T)TGGGC intron-variant

Variation tolerance for ARFIP2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFIP2 Gene

HapMap Linkage Disequilibrium report
ARFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARFIP2 Gene

Disorders for ARFIP2 Gene

Relevant External Links for ARFIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFIP2

No disorders were found for ARFIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP2 Gene

Publications for ARFIP2 Gene

  1. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H. … Exton J.H. (J. Biol. Chem. 1997) 2 3 4 67
  2. Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PMID: 15809304) Rangone H. … Humbert S. (J. Biol. Chem. 2005) 3 23
  3. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. (PMID: 9312003) D'Souza-Schorey C. … Van Aelst L. (EMBO J. 1997) 3 23
  4. Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PMID: 8670882) van Aelst L. … Bar-Sagi D. (EMBO J. 1996) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ARFIP2 Gene

Sources for ARFIP2 Gene

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