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ARFIP2 Gene

protein-coding   GIFtS: 60
GCID: GC11M006496

ADP-Ribosylation Factor Interacting Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor Interacting Protein 21 2     Partner Of RAC1 (Arfaptin 2)2
POR12 3 5     ADP-Ribosylation Factor-Interacting Protein 23
Arfaptin 21     Partner Of RAC13
arfaptin-22     Protein POR13

External Ids:    HGNC: 171601   Entrez Gene: 236472   Ensembl: ENSG000001322547   OMIM: 6016385   UniProtKB: P533653   

Export aliases for ARFIP2 gene to outside databases

Previous GC identifers: GC11M006455 GC11M006461 GC11M006453 GC11M006156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARFIP2 Gene:
ARFIP2 (ADP-ribosylation factor interacting protein 2) is a protein-coding gene. Diseases associated with ARFIP2 include huntington's disease, and malaria. GO annotations related to this gene include Rac GTPase binding and GTP binding. An important paralog of this gene is ARFIP1.

UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365
Function: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling

Gene Wiki entry for ARFIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARFIP2 gene promoter:
         GR   AREB6   Egr-2   PPAR-gamma1   PPAR-gamma2   GR-alpha   TGIF   Pax-4a   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARFIP2 promoter sequence
   Search Chromatin IP Primers for ARFIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARFIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

ARFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFIP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006496:  view genomic region     (about GC identifiers)

Start:
6,495,913 bp from pter      End:
6,502,709 bp from pter
Size:
6,797 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365 (See protein sequence)
Recommended Name: Arfaptin-2  
Size: 341 amino acids; 37856 Da
Subunit: Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds
to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction
leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level
5 PDB 3D structures from and Proteopedia for ARFIP2:
1I49 (3D)        1I4D (3D)        1I4L (3D)        1I4T (3D)        4DCN (3D)    
Secondary accessions: B4DX86 B4E306 D3DQT5
Alternative splicing: 3 isoforms:  P53365-1   P53365-2   P53365-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARFIP2: NX_P53365

Explore proteomics data for ARFIP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARFIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229783.1  NP_001229784.1  NP_001229785.1  NP_036534.1  

    ENSEMBL proteins: 
     ENSP00000254584   ENSP00000379998   ENSP00000434564   ENSP00000434124   ENSP00000398375  
     ENSP00000391427  

    ARFIP2 Human Recombinant Protein Products:

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    Novus Biologicals ARFIP2 Proteins
    Novus Biologicals ARFIP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ARFIP2
    Cloud-Clone Corp. Proteins for ARFIP2

    ARFIP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ARFIP2
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    ThermoFisher Antibodies for ARFIP2
    LSBio Antibodies in human, mouse, rat for ARFIP2

    ARFIP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ARFIP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARFIP2
    Cloud-Clone Corp. CLIAs for ARFIP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR010504 AH_dom

    Graphical View of Domain Structure for InterPro Entry P53365

    ProtoNet protein and cluster: P53365

    1 Blocks protein domain: IPB010504 Arfaptin-like

    UniProtKB/Swiss-Prot: ARFP2_HUMAN, P53365
    Similarity: Contains 1 AH domain


    ARFIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARFP2_HUMAN, P53365
    Function: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11346801
    GO:0005525GTP binding TAS8670882
    GO:0019904protein domain specific binding IEA--
    GO:0030742GTP-dependent protein binding TAS9312003
    GO:0048365Rac GTPase binding TAS9312003
         
    ARFIP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARFIP2:
     Decreased POU5F1-GFP protein e  Decreased circadian period len 

         1 MGI phenotypic allele for Arfip2 (no phenotypes)

    ARFIP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARFIP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARFIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARFIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARFIP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARFIP2:
    hsa-mir-155-5p (MIRT001570), hsa-mir-26b-5p (MIRT029664), hsa-let-7b-5p (MIRT032409)

    Block miRNA regulation of human, mouse, rat ARFIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARFIP2 (see all 52):
    hsa-miR-140-5p hsa-miR-582-3p hsa-miR-520f hsa-miR-328 hsa-miR-488 hsa-miR-192 hsa-miR-4267 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidARFIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARFIP2
    Predesigned siRNA for gene silencing in human, mouse, rat ARFIP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARFIP2

    Clone
    Products:
         
    OriGene clones in human, mouse for ARFIP2 (see all 7)
    OriGene ORF clones in mouse, rat for ARFIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARFIP2 (NM_012402)
    Sino Biological Human cDNA Clone for ARFIP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARFIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFIP2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ARFIP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARFIP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFIP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IMP8670882
    GO:0005737cytoplasm TAS9312003
    GO:0005886plasma membrane TAS9312003
    GO:0005938cell cortex IDA9312003

    ARFIP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARFIP2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Paxillin Interactions0.73
    2Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    3ERK Signaling
    Rho Family GTPases0.61
    4TCR Signaling (Qiagen)
    PDGF Pathway0.39
    5G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARFIP2
        Rac1 Pathway
    Paxillin Interactions
    Huntington's Disease Pathway
    PDGF Pathway
    Rho Family GTPases

    2 GeneGo (Thomson Reuters) Pathways for ARFIP2
        Cytoskeleton remodeling Role of PDGFs in cell migration
    G-protein signaling RAC1 in cellular process

    1 BioSystems Pathway for ARFIP2
        Arf1 pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARFIP2: 
              Cytoskeleton Regulators in human mouse rat
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARFIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ARFIP2 (P533651, 2, 3 ENSP000002545844) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV82, 3, ENSP000003416804MINT-66731 I2D: score=5 STRING: ENSP00000341680
    ITGB3BPQ133522, 3, ENSP000002710024MINT-68205 I2D: score=5 STRING: ENSP00000271002
    RAC1P630001, 3, ENSP000003484614EBI-638194,EBI-413628 I2D: score=5 STRING: ENSP00000348461
    ARF6P623301, 3, ENSP000002983164EBI-638194,EBI-638181 I2D: score=4 STRING: ENSP00000298316
    RAC2P151533, ENSP000002490714I2D: score=3 STRING: ENSP00000249071
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS8670882
    GO:0007264small GTPase mediated signal transduction TAS8670882
    GO:0030032lamellipodium assembly TAS9312003
    GO:0030036actin cytoskeleton organization IMP9312003
    GO:0031529ruffle organization TAS9312003

    ARFIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARFIP2 (ARFP2)

    1 HMDB Compound for ARFIP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for ARFIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 44.4 1 9312003 (1)



    ARFIP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARFIP2 gene (4 alternative transcripts): 
    NM_001242854.1  NM_001242855.1  NM_001242856.1  NM_012402.3  

    Unigene Cluster for ARFIP2:

    ADP-ribosylation factor interacting protein 2
    Hs.75139  [show with all ESTs]
    Unigene Representative Sequence: NM_001242854
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254584(uc001mdk.3 uc010ran.2 uc010ral.2 uc010ram.2)
    ENST00000396777 ENST00000531037 ENST00000525235 ENST00000530410 ENST00000529847
    ENST00000525329 ENST00000423813 ENST00000445086
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARFIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARFIP2 (see all 52):
    hsa-miR-140-5p hsa-miR-582-3p hsa-miR-520f hsa-miR-328 hsa-miR-488 hsa-miR-192 hsa-miR-4267 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidARFIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARFIP2
    Predesigned siRNA for gene silencing in human, mouse, rat ARFIP2
    Clone
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    OriGene clones in human, mouse for ARFIP2 (see all 7)
    OriGene ORF clones in mouse, rat for ARFIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARFIP2 (NM_012402)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARFIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFIP2
    Primer
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    OriGene qPCR primer pairs and template standards for ARFIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARFIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARFIP2
      QuantiTect SYBR Green Assays in human, mouse, rat ARFIP2
      QuantiFast Probe-based Assays in human, mouse, rat ARFIP2

    Additional mRNA sequence: 

    AK026390.1 AK300855.1 AK301856.1 AK301972.1 AK304512.1 AK310267.1 AK311004.1 BC000392.2 
    U52522.1 X97567.1 

    Selected DOTS entries (see all 25):

    DT.317682  DT.95260055  DT.100037134  DT.100864420  DT.95260059  DT.95260067  DT.101959902  DT.120709587 
    DT.120709362  DT.120709466  DT.120709440  DT.95260069  DT.97762248  DT.100658806  DT.120709477  DT.120709519 
    DT.75158730  DT.120709318  DT.120709501  DT.100639536  DT.100731839  DT.100848581  DT.95152152  DT.95260054 

    Selected AceView cDNA sequences (see all 436):

    BX336183 CA454655 BI771126 BI255531 BF531075 CR603783 AU103067 BG744403 
    BU788047 X97567 CA488287 BM927654 CR606576 CA488201 BE795243 BQ063401 
    AA917509 BC000392 BQ934338 Z45069 BQ066356 BU740689 BM700935 AI078487 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP2 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7a · 7b · 7c ^ 8a · 8b ^
    SP1:                                -     -     -           -                 -     -     -     -                             -           -     -     -     -   
    SP2:                                -     -     -           -                 -     -     -     -                             -                             -   
    SP3:                                -     -                 -                 -     -     -     -                             -                             -   
    SP4:                                -     -     -           -                 -     -     -     -                             -                             -   
    SP5:                                -     -                 -                 -     -     -     -                             -                             -   

    ExUns: 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d
    SP1:  -                                                           -                           
    SP2:  -                                                           -                           
    SP3:  -                                                                                       
    SP4:  -                                                                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ARFIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARFIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACATCCTT
    ARFIP2 Expression
    About this image

    ARFIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARFIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75139
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARFIP2: 
              Cytoskeleton Regulators in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARFIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARFIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARFIP2
    QuantiTect SYBR Green Assays in human, mouse, rat ARFIP2
    QuantiFast Probe-based Assays in human, mouse, rat ARFIP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARFIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arfip21 , 5 ADP-ribosylation factor interacting protein 21, 5 94.43(n)1
    99.12(a)1
      7 (55.92 cM)5
    769321  NM_029802.41  NP_084078.31 
     1056342035 
    chicken
    (Gallus gallus)
    Aves ARFIP21 ADP-ribosylation factor interacting protein 2 76.59(n)
    81.69(a)
      419075  XM_004938965.1  XP_004939022.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARFIP26
    ADP-ribosylation factor interacting protein 2
    81(a)
    1 ↔ 1
    GL343952.1(85443-103208)
    zebrafish
    (Danio rerio)
    Actinopterygii arfip2b1 ADP-ribosylation factor interacting protein 2b 71.03(n)
    77.03(a)
      550342  NM_001017649.1  NP_001017649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171841 CG17184 59.3(n)
    56.93(a)
      41353  NM_141801.2  NP_650058.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F54C8.71 F54C8.7 45.4(n)
    32.51(a)
      176326  NM_181932.4  NP_871661.1 


    ENSEMBL Gene Tree for ARFIP2 (if available)
    TreeFam Gene Tree for ARFIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARFIP2 gene
    ARFIP12  
    1 SIMAP similar gene for ARFIP2 using alignment to 3 protein entries:     ARFP2_HUMAN (see all proteins):
    ARFIP1

    ARFIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARFIP2 (see all 85)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430460791,2
    --6497858(+) GGCCAA/GCAATG 4 -- ut310--------
    rs18029211,2
    C,F--6497884(-) AAAGGG/TGTGGG 4 -- ut311Minor allele frequency- T:0.07WA 118
    rs1470064161,2
    --6497909(+) TCTCTA/GCAATG 4 -- ut310--------
    rs1145861251,2
    C,F--6497975(+) AGTCCG/AAGAAG 4 -- ut311Minor allele frequency- A:0.03WA 118
    rs37412691,2
    --6498019(+) CTGTCA/GTTGGT 4 -- ut31 ese30--------
    rs768494001,2
    C,F--6498174(+) CCAGGC/TCCTCT 4 -- ut311Minor allele frequency- T:0.04WA 118
    rs1130873391,2
    C,F--6498175(+) CAGGCA/C/GCTCTT 8 -- ut311CSA 1
    rs1417980601,2
    C--6498464(+) CATTGC/TGGAAG 8 H R mis10--------
    rs1133311041,2
    C,F--6498675(+) AGAAAA/CCTCAC 4 -- int10--------
    rs1505525901,2
    --6498732(+) TTTTCC/TCAGTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for ARFIP2 (6495913 - 6502709 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARFIP2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARFIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARFIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601638    OMIM disorders: --

    2 diseases for ARFIP2:    
    About MalaCards
    huntington's disease    malaria


    ARFIP2 for disorders           About GeneDecksing


    Export disorders for ARFIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARFIP2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ARFIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PubMed id 9038142)1, 2, 3 Kanoh H.... Exton J.H. (J. Biol. Chem. 1997)
    2. Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PubMed id 8670882)1, 2, 3 van Aelst L.... Bar-Sagi D. (EMBO J. 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. (PubMed id 11346801)1, 2 Tarricone C.... Smerdon S.J. (Nature 2001)
    5. Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PubMed id 15809304)1, 9 Rangone H....Humbert S. (J. Biol. Chem. 2005)
    6. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. (PubMed id 9312003)1, 9 D'Souza-Schorey C....Van Aelst L. (EMBO J. 1997)
    7. Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. (PubMed id 23695357)1 Cruz-Garcia D....Malhotra V. (EMBO J. 2013)
    8. Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. (PubMed id 23638170)1 Ambroggio E.E....Goud B. (PLoS ONE 2013)
    9. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    10. Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. (PubMed id 22679020)1 Nakamura K....Wakatsuki S. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23647 HGNC: 17160 AceView: ARFIP2 Ensembl:ENSG00000132254 euGenes: HUgn23647
    ECgene: ARFIP2 H-InvDB: ARFIP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARFIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARFIP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARFIP2 gene:
    Search GeneIP for patents involving ARFIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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