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Aliases for ARFIP2 Gene

Aliases for ARFIP2 Gene

  • ADP Ribosylation Factor Interacting Protein 2 2 3 5
  • POR1 3 4
  • ADP-Ribosylation Factor-Interacting Protein 2 4
  • Partner Of RAC1 (Arfaptin 2) 3
  • Partner Of RAC1 4
  • Protein POR1 4
  • Arfaptin 2 2
  • Arfaptin-2 3

External Ids for ARFIP2 Gene

Previous GeneCards Identifiers for ARFIP2 Gene

  • GC11M006455
  • GC11M006461
  • GC11M006453
  • GC11M006156

Summaries for ARFIP2 Gene

GeneCards Summary for ARFIP2 Gene

ARFIP2 (ADP Ribosylation Factor Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include GTP binding and Rac GTPase binding. An important paralog of this gene is ARFIP1.

UniProtKB/Swiss-Prot for ARFIP2 Gene

  • Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Wiki entry for ARFIP2 Gene

Additional gene information for ARFIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP2 Gene

Genomics for ARFIP2 Gene

Regulatory Elements for ARFIP2 Gene

Enhancers for ARFIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006400 1.3 Ensembl ENCODE dbSUPER 10.3 +78.1 78110 5 SOX13 MXI1 TBL1XR1 BATF POLR2A EED SCRT2 NR2F6 ETV6 RUNX3 SMPD1 HPX ARFIP2 TIMM10B CAVIN3 APBB1 GC11P006400 PIR40798
GH11H006531 0.9 ENCODE 10.5 -50.0 -49977 0 HDAC1 ELF3 HDGF FOXA2 ARNT RAD21 SCRT2 ZNF143 ATF7 ZNF654 ILK RRP8 RPL21P94 MRPL17 ENSG00000254641 TAF10 ENSG00000255410 ARFIP2 TIMM10B APBB1
GH11H006443 0.7 ENCODE 10.6 +37.9 37884 0 CTCF TAF1 ZFP64 TRIM22 MAX REST RAD21 YY1 MTA3 JUND APBB1 ARFIP2 TIMM10B SMPD1 HPX GC11P006457
GH11H006505 0.6 ENCODE 10.7 -24.3 -24347 0 CTCF ZNF654 TRIM22 REST RAD21 ZNF664 ZNF143 SMC3 RUNX3 MIXL1 ARFIP2 TIMM10B APBB1 ILK RRP8 SMPD1 DNHD1 PIR42127
GH11H006506 0.6 ENCODE 10.7 -24.1 -24147 0 ZNF664 CTCF TRIM22 ZNF143 REST RAD21 ARFIP2 TIMM10B APBB1 ILK RRP8 SMPD1 DNHD1 PIR42127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARFIP2 on UCSC Golden Path with GeneCards custom track

Promoters for ARFIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036302 79 1601 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SP3 SP5 ZHX2

Genomic Location for ARFIP2 Gene

Chromosome:
11
Start:
6,474,683 bp from pter
End:
6,481,479 bp from pter
Size:
6,797 bases
Orientation:
Minus strand

Genomic View for ARFIP2 Gene

Genes around ARFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP2 Gene

Proteins for ARFIP2 Gene

  • Protein details for ARFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53365-ARFP2_HUMAN
    Recommended name:
    Arfaptin-2
    Protein Accession:
    P53365
    Secondary Accessions:
    • B4DX86
    • B4E306
    • D3DQT5

    Protein attributes for ARFIP2 Gene

    Size:
    341 amino acids
    Molecular mass:
    37856 Da
    Quaternary structure:
    • Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level.

    Three dimensional structures from OCA and Proteopedia for ARFIP2 Gene

    Alternative splice isoforms for ARFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFIP2 Gene

Post-translational modifications for ARFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARFIP2 Gene

Domains & Families for ARFIP2 Gene

Gene Families for ARFIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ARFIP2 Gene

Suggested Antigen Peptide Sequences for ARFIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARFIP2: view

No data available for UniProtKB/Swiss-Prot for ARFIP2 Gene

Function for ARFIP2 Gene

Molecular function for ARFIP2 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.

Gene Ontology (GO) - Molecular Function for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8670882
GO:0005525 GTP binding TAS 8670882
GO:0019904 protein domain specific binding IEA --
GO:0030742 GTP-dependent protein binding TAS 9312003
GO:0042802 identical protein binding IPI 8670882
genes like me logo Genes that share ontologies with ARFIP2: view
genes like me logo Genes that share phenotypes with ARFIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARFIP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP2 Gene

Localization for ARFIP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARFIP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IMP 8670882
GO:0005737 cytoplasm TAS 9312003
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 9312003
GO:0005938 cell cortex IDA 9312003
genes like me logo Genes that share ontologies with ARFIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP2 Gene

Pathways & Interactions for ARFIP2 Gene

genes like me logo Genes that share pathways with ARFIP2: view

SIGNOR curated interactions for ARFIP2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for ARFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 8670882
GO:0007264 small GTPase mediated signal transduction TAS 8670882
GO:0030032 lamellipodium assembly TAS 9312003
GO:0030036 actin cytoskeleton organization IMP 9312003
GO:0031529 ruffle organization TAS 9312003
genes like me logo Genes that share ontologies with ARFIP2: view

Drugs & Compounds for ARFIP2 Gene

(1) Drugs for ARFIP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for ARFIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARFIP2: view

Transcripts for ARFIP2 Gene

Unigene Clusters for ARFIP2 Gene

ADP-ribosylation factor interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARFIP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7a · 7b · 7c ^ 8a · 8b ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - -
SP18: - -
SP19: -
SP20:
SP21: - -
SP22: - - -
SP23: -
SP24: - - - - - - - -
SP25:

ExUns: 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - -

Relevant External Links for ARFIP2 Gene

GeneLoc Exon Structure for
ARFIP2
ECgene alternative splicing isoforms for
ARFIP2

Expression for ARFIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARFIP2 Gene

Protein differential expression in normal tissues from HIPED for ARFIP2 Gene

This gene is overexpressed in Nasal epithelium (13.4), Skin (12.3), Brain (10.5), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARFIP2 Gene



Protein tissue co-expression partners for ARFIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARFIP2 Gene:

ARFIP2

SOURCE GeneReport for Unigene cluster for ARFIP2 Gene:

Hs.75139

Evidence on tissue expression from TISSUES for ARFIP2 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Lung(4.3)
  • Intestine(2.4)
  • Lymph node(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ARFIP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFIP2 Gene

Orthologs for ARFIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFIP2 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ARFIP2 33 34
  • 96.68 (n)
cow
(Bos Taurus)
Mammalia ARFIP2 33 34
  • 95.5 (n)
oppossum
(Monodelphis domestica)
Mammalia ARFIP2 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfip2 33 16 34
  • 94.43 (n)
rat
(Rattus norvegicus)
Mammalia Arfip2 33
  • 93.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARFIP2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARFIP2 33 34
  • 76.59 (n)
lizard
(Anolis carolinensis)
Reptilia ARFIP2 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arfip2b 33 34
  • 71.03 (n)
arfip2a 34
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17184 33 34
  • 59.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004910 33
  • 55.92 (n)
worm
(Caenorhabditis elegans)
Secernentea F54C8.7 33 34
  • 45.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 34
  • 60 (a)
OneToMany
Species where no ortholog for ARFIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARFIP2 Gene

ENSEMBL:
Gene Tree for ARFIP2 (if available)
TreeFam:
Gene Tree for ARFIP2 (if available)

Paralogs for ARFIP2 Gene

Paralogs for ARFIP2 Gene

(1) SIMAP similar genes for ARFIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARFIP2: view

Variants for ARFIP2 Gene

Sequence variations from dbSNP and Humsavar for ARFIP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000365664 -- 6,481,926(+) CACTT(C/G)CCGTA intron-variant, upstream-variant-2KB
rs1001483841 -- 6,482,248(+) AAGGC(C/T)TTGGA upstream-variant-2KB, utr-variant-3-prime
rs1001714070 -- 6,476,408(+) CAGCT(A/G)CCTGG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1002050326 -- 6,482,457(+) AGTGC(A/G)TATCT upstream-variant-2KB, utr-variant-3-prime
rs1002596206 -- 6,477,647(+) AATGG(A/G)GAGGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFIP2 Gene

Variant ID Type Subtype PubMed ID
esv3625266 CNV gain 21293372
nsv972944 CNV duplication 23825009

Variation tolerance for ARFIP2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP2 Gene

Disorders for ARFIP2 Gene

Relevant External Links for ARFIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFIP2

No disorders were found for ARFIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP2 Gene

Publications for ARFIP2 Gene

  1. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H … Exton JH (The Journal of biological chemistry 1997) 2 3 4 60
  2. Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PMID: 8670882) Van Aelst L … Bar-Sagi D (The EMBO journal 1996) 2 3 4 60
  3. Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PMID: 15809304) Rangone H … Humbert S (The Journal of biological chemistry 2005) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. (PMID: 11346801) Tarricone C … Smerdon SJ (Nature 2001) 3 4 60

Products for ARFIP2 Gene

Sources for ARFIP2 Gene

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