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Aliases for ARFIP1 Gene

Aliases for ARFIP1 Gene

  • ADP-Ribosylation Factor Interacting Protein 1 2 3
  • ADP-Ribosylation Factor-Interacting Protein 1 4
  • Arfaptin 1 2
  • Arfaptin-1 3
  • HSU52521 3

External Ids for ARFIP1 Gene

Previous GeneCards Identifiers for ARFIP1 Gene

  • GC04P154167
  • GC04P154278
  • GC04P154058
  • GC04P153920
  • GC04P153701
  • GC04P149427

Summaries for ARFIP1 Gene

GeneCards Summary for ARFIP1 Gene

ARFIP1 (ADP-Ribosylation Factor Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is ARFIP2.

UniProtKB/Swiss-Prot for ARFIP1 Gene

  • Putative target protein of ADP-ribosylation factor

Gene Wiki entry for ARFIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP1 Gene

Genomics for ARFIP1 Gene

Regulatory Elements for ARFIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARFIP1 Gene

Start:
152,687,727 bp from pter
End:
152,918,463 bp from pter
Size:
230,737 bases
Orientation:
Plus strand

Genomic View for ARFIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARFIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP1 Gene

Proteins for ARFIP1 Gene

  • Protein details for ARFIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53367-ARFP1_HUMAN
    Recommended name:
    Arfaptin-1
    Protein Accession:
    P53367
    Secondary Accessions:
    • B4DS69
    • Q2M2X4
    • Q3SYL4
    • Q9Y2X6

    Protein attributes for ARFIP1 Gene

    Size:
    373 amino acids
    Molecular mass:
    41738 Da
    Quaternary structure:
    • Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.

    Alternative splice isoforms for ARFIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFIP1 Gene

Proteomics data for ARFIP1 Gene at MOPED

Post-translational modifications for ARFIP1 Gene

  • Ubiquitination at Lys353
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ARFIP1 Gene

Domains for ARFIP1 Gene

Protein Domains for ARFIP1 Gene

Graphical View of Domain Structure for InterPro Entry

P53367

UniProtKB/Swiss-Prot:

ARFP1_HUMAN :
  • P53367
Domain:
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ARFIP1: view

No data available for Gene Families for ARFIP1 Gene

Function for ARFIP1 Gene

Molecular function for ARFIP1 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor

Gene Ontology (GO) - Molecular Function for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0019904 protein domain specific binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IDA 23695357
genes like me logo Genes that share ontologies with ARFIP1: view

Animal Model Products

miRNA for ARFIP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARFIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARFIP1 Gene

Localization for ARFIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARFIP1 Gene COMPARTMENTS Subcellular localization image for ARFIP1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2

Gene Ontology (GO) - Cellular Components for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 9038142
GO:0005829 cytosol IDA 9038142
GO:0032588 trans-Golgi network membrane IDA 23695357
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP1 Gene

Pathways for ARFIP1 Gene

SuperPathways for ARFIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 12606037
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IBA --
GO:0050708 regulation of protein secretion IDA 12606037
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Pathways by source for ARFIP1 Gene

Compounds for ARFIP1 Gene

(1) HMDB Compounds for ARFIP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARFIP1: view

Transcripts for ARFIP1 Gene

Unigene Clusters for ARFIP1 Gene

ADP-ribosylation factor interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARFIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c · 13d · 13e ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8:
SP9: - - - - - - - - - -
SP10: - -
SP11: -
SP12:
SP13: - - - - - -
SP14: - - - - -

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ARFIP1 Gene

GeneLoc Exon Structure for
ARFIP1
ECgene alternative splicing isoforms for
ARFIP1

Expression for ARFIP1 Gene

mRNA expression in normal human tissues for ARFIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ARFIP1 Gene

This gene is overexpressed in Nasal epithelium (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFIP1 Gene

SOURCE GeneReport for Unigene cluster for ARFIP1 Gene Hs.416089

mRNA Expression by UniProt/SwissProt for ARFIP1 Gene

P53367-ARFP1_HUMAN
Tissue specificity: Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart
genes like me logo Genes that share expressions with ARFIP1: view

Expression partners for ARFIP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARFIP1 Gene

Orthologs for ARFIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARFIP1 35
  • 94.64 (n)
  • 97.32 (a)
ARFIP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARFIP1 35
  • 95.26 (n)
  • 97.59 (a)
ARFIP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfip1 35
  • 89.81 (n)
  • 92.49 (a)
Arfip1 16
Arfip1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARFIP1 35
  • 100 (n)
  • 100 (a)
ARFIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arfip1 35
  • 90.71 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia ARFIP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARFIP1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARFIP1 35
  • 84.19 (n)
  • 90.03 (a)
ARFIP1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARFIP1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arfip1 35
  • 77.78 (n)
  • 84.21 (a)
Str.19914 35
African clawed frog
(Xenopus laevis)
Amphibia loc60382-prov 35
zebrafish
(Danio rerio)
Actinopterygii arfip1 35
  • 68.34 (n)
  • 74.26 (a)
idibd2077 35
arfip1 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1457 35
fruit fly
(Drosophila melanogaster)
Insecta CG17184 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F54C8.7 36
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5370 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 36
  • 58 (a)
OneToMany
Species with no ortholog for ARFIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFIP1 Gene

ENSEMBL:
Gene Tree for ARFIP1 (if available)
TreeFam:
Gene Tree for ARFIP1 (if available)

Paralogs for ARFIP1 Gene

Paralogs for ARFIP1 Gene

Selected SIMAP similar genes for ARFIP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARFIP1: view

Variants for ARFIP1 Gene

Sequence variations from dbSNP and Humsavar for ARFIP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4254753 -- 152,878,877(+) GGCTT(G/T)TGAAT intron-variant
rs4305500 -- 152,795,365(+) ccccc(A/C)acagt intron-variant
rs4350995 -- 152,811,062(+) gaaat(C/G)gacaa intron-variant
rs4359885 -- 152,851,630(+) TTTTA(A/G)AAAAC intron-variant
rs4380505 -- 152,819,378(+) AAGGC(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFIP1 Gene

Variant ID Type Subtype PubMed ID
nsv522511 CNV Loss 19592680
nsv516652 CNV Loss 19592680
nsv520249 CNV Loss 19592680
nsv830117 CNV Gain 17160897

Relevant External Links for ARFIP1 Gene

HapMap Linkage Disequilibrium report
ARFIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP1 Gene

Disorders for ARFIP1 Gene

No disorders were found for ARFIP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARFIP1 Gene

Publications for ARFIP1 Gene

  1. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. (PMID: 10413101) Williger B.-T. … Exton J.H. (FEBS Lett. 1999) 2 3 4 23
  2. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H. … Exton J.H. (J. Biol. Chem. 1997) 2 3 4
  3. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. (PMID: 12606037) Ho W.T. … Williger B.T. (FEBS Lett. 2003) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARFIP1 Gene

Sources for ARFIP1 Gene

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