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Aliases for ARFIP1 Gene

Aliases for ARFIP1 Gene

  • ADP Ribosylation Factor Interacting Protein 1 2 3 5
  • ADP-Ribosylation Factor-Interacting Protein 1 3 4
  • Arfaptin 1 2
  • Arfaptin-1 3
  • HSU52521 3

External Ids for ARFIP1 Gene

Previous GeneCards Identifiers for ARFIP1 Gene

  • GC04P154167
  • GC04P154278
  • GC04P154058
  • GC04P153920
  • GC04P153701
  • GC04P149427
  • GC04P152687

Summaries for ARFIP1 Gene

GeneCards Summary for ARFIP1 Gene

ARFIP1 (ADP Ribosylation Factor Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is ARFIP2.

UniProtKB/Swiss-Prot for ARFIP1 Gene

  • Putative target protein of ADP-ribosylation factor.

Gene Wiki entry for ARFIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP1 Gene

Genomics for ARFIP1 Gene

Regulatory Elements for ARFIP1 Gene

Enhancers for ARFIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARFIP1 on UCSC Golden Path with GeneCards custom track

Promoters for ARFIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARFIP1 Gene

152,779,937 bp from pter
152,918,463 bp from pter
138,527 bases
Plus strand

Genomic View for ARFIP1 Gene

Genes around ARFIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFIP1 Gene

Proteins for ARFIP1 Gene

  • Protein details for ARFIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DS69
    • Q2M2X4
    • Q3SYL4
    • Q9Y2X6

    Protein attributes for ARFIP1 Gene

    373 amino acids
    Molecular mass:
    41738 Da
    Quaternary structure:
    • Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.

    Alternative splice isoforms for ARFIP1 Gene


neXtProt entry for ARFIP1 Gene

Post-translational modifications for ARFIP1 Gene

  • Ubiquitination at Lys 353
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARFIP1 Gene

Domains & Families for ARFIP1 Gene

Gene Families for ARFIP1 Gene

Protein Domains for ARFIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AH domain.
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ARFIP1: view

Function for ARFIP1 Gene

Molecular function for ARFIP1 Gene

UniProtKB/Swiss-Prot Function:
Putative target protein of ADP-ribosylation factor.

Gene Ontology (GO) - Molecular Function for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019904 protein domain specific binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IDA 23695357
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with ARFIP1: view
genes like me logo Genes that share phenotypes with ARFIP1: view

Animal Model Products

CRISPR Products

miRNA for ARFIP1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP1 Gene

Localization for ARFIP1 Gene

Subcellular locations from

Jensen Localization Image for ARFIP1 Gene COMPARTMENTS Subcellular localization image for ARFIP1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2

Gene Ontology (GO) - Cellular Components for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 9038142
GO:0005829 cytosol IDA 9038142
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0032588 trans-Golgi network membrane IDA 23695357
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP1 Gene

Pathways & Interactions for ARFIP1 Gene

SuperPathways for ARFIP1 Gene

No Data Available

SIGNOR curated interactions for ARFIP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 12606037
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IBA --
GO:0050708 regulation of protein secretion IDA 12606037
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ARFIP1: view

No data available for Pathways by source for ARFIP1 Gene

Drugs & Compounds for ARFIP1 Gene

(1) Drugs for ARFIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARFIP1: view

Transcripts for ARFIP1 Gene

Unigene Clusters for ARFIP1 Gene

ADP-ribosylation factor interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c · 13d · 13e ^ 14 ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP9: - - - - - - - - - -
SP10: - -
SP11: -
SP13: - - - - - -
SP14: - - - - -

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: -
SP2: -
SP3: -
SP12: -

Relevant External Links for ARFIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARFIP1 Gene

mRNA expression in normal human tissues for ARFIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARFIP1 Gene

This gene is overexpressed in Nasal epithelium (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARFIP1 Gene

Protein tissue co-expression partners for ARFIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARFIP1 Gene:


SOURCE GeneReport for Unigene cluster for ARFIP1 Gene:


mRNA Expression by UniProt/SwissProt for ARFIP1 Gene:

Tissue specificity: Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with ARFIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARFIP1 Gene

Orthologs for ARFIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARFIP1 34
  • 94.64 (n)
  • 97.32 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ARFIP1 34
  • 95.26 (n)
  • 97.59 (a)
  • 91 (a)
(Mus musculus)
Mammalia Arfip1 34
  • 89.81 (n)
  • 92.49 (a)
Arfip1 16
Arfip1 35
  • 92 (a)
(Pan troglodytes)
Mammalia ARFIP1 34
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arfip1 34
  • 90.71 (n)
  • 92.9 (a)
(Monodelphis domestica)
Mammalia ARFIP1 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ARFIP1 35
  • 83 (a)
(Gallus gallus)
Aves ARFIP1 34
  • 84.19 (n)
  • 90.03 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia ARFIP1 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arfip1 34
  • 77.78 (n)
  • 84.21 (a)
Str.19914 34
African clawed frog
(Xenopus laevis)
Amphibia loc60382-prov 34
(Danio rerio)
Actinopterygii arfip1 34
  • 68.34 (n)
  • 74.26 (a)
idibd2077 34
arfip1 35
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1457 34
fruit fly
(Drosophila melanogaster)
Insecta CG17184 35
  • 44 (a)
(Caenorhabditis elegans)
Secernentea F54C8.7 35
  • 29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5370 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9407 35
  • 58 (a)
Species where no ortholog for ARFIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFIP1 Gene

Gene Tree for ARFIP1 (if available)
Gene Tree for ARFIP1 (if available)

Paralogs for ARFIP1 Gene

Paralogs for ARFIP1 Gene

(1) SIMAP similar genes for ARFIP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARFIP1: view

Variants for ARFIP1 Gene

Sequence variations from dbSNP and Humsavar for ARFIP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4254753 -- 152,878,877(+) GGCTT(G/T)TGAAT intron-variant
rs4461505 -- 152,820,827(+) cgact(A/G)gcatc intron-variant
rs4380505 -- 152,819,378(+) AAGGC(A/G)ACACA intron-variant
rs4388067 -- 152,789,855(+) tgagc(A/C)ctttt intron-variant
rs4388068 -- 152,854,207(+) cgcac(C/T)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFIP1 Gene

Variant ID Type Subtype PubMed ID
esv2763399 CNV gain 21179565
esv3602715 CNV loss 21293372
nsv1136914 CNV deletion 24896259
nsv516652 CNV loss 19592680
nsv520249 CNV loss 19592680
nsv522511 CNV loss 19592680
nsv830117 CNV gain 17160897
nsv980266 CNV duplication 23825009

Variation tolerance for ARFIP1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP1 Gene

Disorders for ARFIP1 Gene

Relevant External Links for ARFIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARFIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP1 Gene

Publications for ARFIP1 Gene

  1. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. (PMID: 10413101) Williger B.-T. … Exton J.H. (FEBS Lett. 1999) 2 3 4 22 65
  2. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H. … Exton J.H. (J. Biol. Chem. 1997) 2 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. (PMID: 12606037) Ho W.T. … Williger B.T. (FEBS Lett. 2003) 3 22 65

Products for ARFIP1 Gene

Sources for ARFIP1 Gene

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