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Aliases for ARFGEF3 Gene

Aliases for ARFGEF3 Gene

  • ARFGEF Family Member 3 2 3
  • KIAA1244 2 3 4
  • C6orf92 3 4
  • BIG3 3 4
  • Brefeldin A-Inhibited Guanine Nucleotide-Exchange Protein 3 3
  • Protein Phosphatase 1, Regulatory Subunit 33 3
  • Chromosome 6 Open Reading Frame 92 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 33 2
  • DJ171N11.1 3
  • PPP1R33 3
  • A7322 3

External Ids for ARFGEF3 Gene

Previous Symbols for ARFGEF3 Gene

  • C6orf92
  • KIAA1244

Summaries for ARFGEF3 Gene

GeneCards Summary for ARFGEF3 Gene

ARFGEF3 (ARFGEF Family Member 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGEF3 Gene

Genomics for ARFGEF3 Gene

Genomic Location for ARFGEF3 Gene

138,161,916 bp from pter
138,344,663 bp from pter
182,748 bases
Plus strand

Genomic View for ARFGEF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARFGEF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGEF3 Gene

No data available for Regulatory Elements for ARFGEF3 Gene

Proteins for ARFGEF3 Gene

  • Protein details for ARFGEF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brefeldin A-inhibited guanine nucleotide-exchange protein 3
    Protein Accession:
    Secondary Accessions:
    • Q76MU8
    • Q8N4Y4
    • Q96CH9
    • Q96P46
    • Q9ULH6

    Protein attributes for ARFGEF3 Gene

    2177 amino acids
    Molecular mass:
    240652 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARFGEF3 Gene

Proteomics data for ARFGEF3 Gene at MOPED

Post-translational modifications for ARFGEF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARFGEF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARFGEF3 Gene

Domains for ARFGEF3 Gene

Gene Families for ARFGEF3 Gene

  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for ARFGEF3 Gene


  • Contains 1 SEC7 domain.:
    • Q5TH69
genes like me logo Genes that share domains with ARFGEF3: view

Function for ARFGEF3 Gene

Gene Ontology (GO) - Molecular Function for ARFGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with ARFGEF3: view

Phenotypes for ARFGEF3 Gene

GenomeRNAi human phenotypes for ARFGEF3:
genes like me logo Genes that share phenotypes with ARFGEF3: view

miRNA for ARFGEF3 Gene

miRTarBase miRNAs that target ARFGEF3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARFGEF3 Gene

Localization for ARFGEF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGEF3 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ARFGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARFGEF3: view

Pathways for ARFGEF3 Gene

SuperPathways for ARFGEF3 Gene

No Data Available

Interacting Proteins for ARFGEF3 Gene

Gene Ontology (GO) - Biological Process for ARFGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016192 vesicle-mediated transport IBA --
GO:0032012 regulation of ARF protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARFGEF3: view

No data available for Pathways by source for ARFGEF3 Gene

Transcripts for ARFGEF3 Gene

mRNA/cDNA for ARFGEF3 Gene

(1) REFSEQ mRNAs :
(159) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGEF3 Gene

No ASD Table

Relevant External Links for ARFGEF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARFGEF3 Gene

mRNA expression in normal human tissues for ARFGEF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARFGEF3 Gene

genes like me logo Genes that share expressions with ARFGEF3: view

Orthologs for ARFGEF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARFGEF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA1244 36
  • 99.6 (n)
  • 99.86 (a)
KIAA1244 37
  • 100 (a)
(Bos Taurus)
Mammalia KIAA1244 36
  • 88.86 (n)
  • 94.57 (a)
KIAA1244 37
  • 94 (a)
(Canis familiaris)
Mammalia KIAA1244 36
  • 88.56 (n)
  • 93.39 (a)
KIAA1244 37
  • 93 (a)
(Mus musculus)
Mammalia D10Bwg1379e 36
  • 86.54 (n)
  • 93.22 (a)
D10Bwg1379e 16
D10Bwg1379e 37
  • 93 (a)
(Monodelphis domestica)
Mammalia KIAA1244 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA1244 37
  • 76 (a)
(Gallus gallus)
Aves KIAA1244 36
  • 77.73 (n)
  • 84.81 (a)
KIAA1244 37
  • 85 (a)
(Anolis carolinensis)
Reptilia KIAA1244 37
  • 84 (a)
(Danio rerio)
Actinopterygii KIAA1244 (1 of 2) 37
  • 77 (a)
LOC562652 36
  • 69.32 (n)
  • 74.23 (a)
si:ch211-71k24.5 37
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000635 36
  • 46.88 (n)
  • 35.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5937 36
  • 45.85 (n)
  • 33.96 (a)
CG5937 37
  • 27 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y106G6G.2 36
  • 41.79 (n)
  • 27.79 (a)
Y106G6G.2 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
Species with no ortholog for ARFGEF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARFGEF3 Gene

Gene Tree for ARFGEF3 (if available)
Gene Tree for ARFGEF3 (if available)

Paralogs for ARFGEF3 Gene

Selected SIMAP similar genes for ARFGEF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARFGEF3: view

No data available for Paralogs for ARFGEF3 Gene

Variants for ARFGEF3 Gene

Sequence variations from dbSNP and Humsavar for ARFGEF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs203134 -- 138,286,406(-) GTGGC(A/G)CAATC intron-variant
rs203135 -- 138,285,410(-) gtggc(A/G)tgatc intron-variant
rs203136 -- 138,285,115(-) cagct(A/C)aaatt intron-variant
rs203137 -- 138,279,215(-) CATAG(C/T)GAGAC intron-variant
rs203138 -- 138,278,148(-) AAGAA(C/T)TGACT intron-variant

Relevant External Links for ARFGEF3 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for ARFGEF3 Gene

Disorders for ARFGEF3 Gene

No disorders were found for ARFGEF3 Gene.

No data available for UniProtKB/Swiss-Prot for ARFGEF3 Gene

Publications for ARFGEF3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  3. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. (PMID: 11551928) Gori F. … Demay M.B. (J. Biol. Chem. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ARFGEF3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ARFGEF3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ARFGEF3
    • Block miRNA regulation of ARFGEF3 using miScript Target Protectors

    Sources for ARFGEF3 Gene

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